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SET domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   SET domain [ 82199] (3)
Families:   Histone lysine methyltransferases [ 82200] (3)
  Viral histone H3 Lysine 27 Methyltransferase [ 82207]
  RuBisCo LSMT catalytic domain [ 82210]


Superfamily statistics
Genomes (940) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 18,958 56,585 13
Proteins 18,582 55,527 13


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)primary immunodeficiency disease0.03477InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.000007425Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0002483Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.02351Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.07932Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.08716Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1085Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1479Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1848Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2669Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4842Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.0005981Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.004033Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.005844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02974Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.04204Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.0596Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.06168Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.06174Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.06907Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.09648Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.155Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.1583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.6094Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal testis morphology0.000006283InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.0001832InformativeDirect
Phenotypic Abnormality (PA)Congenital abnormal hair pattern0.000587InformativeDirect
Phenotypic Abnormality (PA)Global developmental delay0.0005902InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.002541InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.01468InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.01979InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.02507InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.05852InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.07033InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.07189InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.1069InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.1753InformativeInherited
Phenotypic Abnormality (PA)Abnormal ureter physiology0.00002893Highly InformativeDirect
Phenotypic Abnormality (PA)Posteriorly rotated ears0.0002369Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0002629Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the frontal hairline0.0004867Highly InformativeDirect
Phenotypic Abnormality (PA)Precocious puberty0.000554Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.001096Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ulna0.002567Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the radius0.006845Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urethra0.009812Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of mouth shape0.03067Highly InformativeInherited
Phenotypic Abnormality (PA)Synostosis of joints0.03621Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.3012Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3247Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3507Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3735Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0008831Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.1999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.2347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.322Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.9589Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.0008927InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.001476InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.01008Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01012Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.07984Least InformativeInherited
Worm Phenotype (WP)cell development variant0.3494Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.0000002339Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000001369Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.005499Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.04147Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.1828Moderately InformativeInherited
Worm Phenotype (WP)sterile progeny0.5285Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.7736Moderately InformativeInherited
Worm Phenotype (WP)life span variant0InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.00000001612InformativeDirect
Worm Phenotype (WP)protein modification variant0.00000002279InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.00003403InformativeDirect
Worm Phenotype (WP)non apoptotic cell death variant0.0001414InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.001261InformativeInherited
Worm Phenotype (WP)vulva development variant0.007188InformativeInherited
Worm Phenotype (WP)protein methylation variant0Highly InformativeDirect
Worm Phenotype (WP)transgenerational loss of fertility0.00000000002615Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.0000004291Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000000759Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.000002765Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.00002552Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01127Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.05532Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.2498Highly InformativeInherited
Worm Phenotype (WP)transgene silencing variant0.4979Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.00000000336InformativeDirect
Fly Phenotype (FP)suppressor of variegation0.0000000007452Highly InformativeDirect
Fly Phenotype (FP)non-suppressor of variegation0.00002574Highly InformativeDirect
Fly Phenotype (FP)homeotic0.0001197Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.4289Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4565Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)thorax0.1355Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.3979Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4078Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.5278Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.5847Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.7421Moderately InformativeInherited
Fly Anatomy (FA)adult metathoracic segment0.002375Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.001444Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.03893Least InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SET domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the SET domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]