SUPERFAMILY 1.75 HMM library and genome assignments server

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Histone lysine methyltransferases family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   SET domain [ 82199] (3)
Family:   Histone lysine methyltransferases [ 82200] (3)


Family statistics
Genomes (333) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,226 2,998 10
Proteins 1,225 2,996 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Mode of Inheritance (MI)Sporadic0.0006389Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.01904Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03657Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.04071Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.04636Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.06681Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.09247Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1384Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1436Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skull size0.00002669Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.0002392Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.0003584Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.0004949Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.000657Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.009387Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.00967Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.01894Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02898Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.04831Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0629Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08243Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1028Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.3062Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.3422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.4697Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.6395Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Global developmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.00006745InformativeDirect
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.00008137InformativeDirect
Phenotypic Abnormality (PA)Hernia0.0001238InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.0002023InformativeDirect
Phenotypic Abnormality (PA)Regional abnormality of skin0.0004547InformativeDirect
Phenotypic Abnormality (PA)Obesity0.0008161InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the outer ear0.0008925InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.003181InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.004243InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.004408InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.00684InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.01237InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.1575InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.2832InformativeInherited
Phenotypic Abnormality (PA)Cryptorchidism0.000002482Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal ureter physiology0.00000605Highly InformativeDirect
Phenotypic Abnormality (PA)Precocious puberty0.00002625Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.00003718Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hairline0.0001725Highly InformativeDirect
Phenotypic Abnormality (PA)Feeding difficulties0.0002335Highly InformativeDirect
Phenotypic Abnormality (PA)Talipes0.0003246Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertelorism0.0006002Highly InformativeDirect
Phenotypic Abnormality (PA)Downturned corners of mouth0.0006455Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aggressive, impulsive or violent behavior0.0009092Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.002957Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urethra0.005252Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.08483Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal location of ears0.3847Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0004308Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.1798Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01746Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0728Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.5484Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0007246InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.821InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0004558Highly InformativeDirect
Mammalian Phenotype (MP)arrest of spermatogenesis0.00617Highly InformativeInherited
Mammalian Phenotype (MP)abnormal male meiosis0.01524Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.003286Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.003286Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01387Least InformativeInherited
Worm Phenotype (WP)cell development variant0.08818Least InformativeInherited
Worm Phenotype (WP)sterile progeny0.6642Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000322Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006664Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.02074Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.05067Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.1196Moderately InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.0000006043InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.00002813InformativeDirect
Worm Phenotype (WP)vulva development variant0.005832InformativeInherited
Worm Phenotype (WP)RNA expression variant0.0318InformativeInherited
Worm Phenotype (WP)RNAi response variant0.00000002075Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.000001697Highly InformativeDirect
Worm Phenotype (WP)multivulva0.000003569Highly InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.00001474Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.0006263Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.006609Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.03808Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.1059Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.03048Moderately InformativeInherited
Fly Phenotype (FP)modifier of variegation0.0000001569InformativeDirect
Fly Phenotype (FP)visible0.0001804InformativeDirect
Fly Phenotype (FP)suppressor of variegation0.00000001531Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00001858Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.09677Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1092Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1823Least InformativeInherited
Fly Anatomy (FA)adult0.2015Least InformativeInherited
Fly Anatomy (FA)segment0.296Least InformativeInherited
Fly Anatomy (FA)larva0.5457Least InformativeInherited
Fly Anatomy (FA)larval tagma0.02709Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.1694Moderately InformativeInherited
Fly Anatomy (FA)appendage0.354Moderately InformativeInherited
Fly Anatomy (FA)imaginal disc0.007109InformativeInherited
Fly Anatomy (FA)leg0.02032InformativeInherited
Fly Anatomy (FA)adult metathoracic segment0.0008807Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)pericardial region0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.001333Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.02857Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.03946Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01189Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.05908Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0005772Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SET domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]