SUPERFAMILY 1.75 HMM library and genome assignments server

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Histone lysine methyltransferases family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   SET domain [ 82199] (3)
Family:   Histone lysine methyltransferases [ 82200] (3)


Family statistics
Genomes (333) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,226 2,998 10
Proteins 1,225 2,996 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Mode of Inheritance (MI)Sporadic0.000591Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.01989Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03804Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.04375Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.04889Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.06842Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.0952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.14Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1431Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skull size0.00003082Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0002281Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.0004131Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.0005425Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.0007128Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0.009842Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.009904Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.01961Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02948Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.05145Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.06225Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.3169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.3509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.4827Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.6489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.00007406InformativeDirect
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0000859InformativeDirect
Phenotypic Abnormality (PA)Hernia0.0001283InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.0002461InformativeDirect
Phenotypic Abnormality (PA)Regional abnormality of skin0.0004594InformativeDirect
Phenotypic Abnormality (PA)Obesity0.0008472InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the outer ear0.0009888InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.003211InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.007328InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.01228InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip joint0.0338InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.1626InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.2829InformativeInherited
Phenotypic Abnormality (PA)Cryptorchidism0.000002746Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal ureter physiology0.000006035Highly InformativeDirect
Phenotypic Abnormality (PA)Ventriculomegaly0.000008982Highly InformativeDirect
Phenotypic Abnormality (PA)Precocious puberty0.00003435Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0000415Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hairline0.0002094Highly InformativeDirect
Phenotypic Abnormality (PA)Feeding difficulties0.0002739Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertelorism0.0006161Highly InformativeDirect
Phenotypic Abnormality (PA)Downturned corners of mouth0.0006881Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urethra0.005204Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.08512Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal location of ears0.3936Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0004299Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.1797Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01747Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0728Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.5485Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0007239InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.821InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0004556Highly InformativeDirect
Mammalian Phenotype (MP)arrest of spermatogenesis0.006171Highly InformativeInherited
Mammalian Phenotype (MP)abnormal male meiosis0.01525Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0002964Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001316Least InformativeInherited
Worm Phenotype (WP)cell development variant0.06242Least InformativeInherited
Worm Phenotype (WP)progeny variant0.4498Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.00001176Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.001891Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.004923Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.0304Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.056Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.07803Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.0000000000005309InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0000006947InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.00003472InformativeDirect
Worm Phenotype (WP)vulva development variant0.00716InformativeInherited
Worm Phenotype (WP)RNA expression variant0.05683InformativeInherited
Worm Phenotype (WP)apoptosis increased0.000001217Highly InformativeDirect
Worm Phenotype (WP)multivulva0.000003699Highly InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.0002693Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.0007257Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.008904Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.03917Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.1147Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)visible0.0001821Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.03113Moderately InformativeInherited
Fly Phenotype (FP)modifier of variegation0.00000015InformativeDirect
Fly Phenotype (FP)suppressor of variegation0.00000001526Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00001821Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.08272Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.09608Least InformativeInherited
Fly Anatomy (FA)adult0.09628Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1656Least InformativeInherited
Fly Anatomy (FA)segment0.2901Least InformativeInherited
Fly Anatomy (FA)larva0.4927Least InformativeInherited
Fly Anatomy (FA)larval segment0.008214Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.04895Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05641Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.1574Moderately InformativeInherited
Fly Anatomy (FA)appendage0.395Moderately InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.004879InformativeInherited
Fly Anatomy (FA)imaginal disc0.007297InformativeInherited
Fly Anatomy (FA)leg0.02113InformativeInherited
Fly Anatomy (FA)dorsal thoracic disc0.0002013Highly InformativeDirect
Fly Anatomy (FA)metathoracic segment0.01477Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.001317Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.02852Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.03092Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01955Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.05956Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.000635Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SET domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]