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Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Superfamily statistics
Genomes (2,965) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 38,206 341,257 4
Proteins 21,625 194,271 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethylglutaryl-CoA reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.005037Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0.0001774InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1784Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1789Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.229Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.06372Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1018Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1053Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.00649InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.01138InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.01197InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the distal phalanges of the hand0.0001051Highly InformativeDirect
Phenotypic Abnormality (PA)Iris coloboma0.0001377Highly InformativeDirect
Phenotypic Abnormality (PA)Short phalanx of finger0.000388Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal hand morphology0.002202Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.004969Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.007351Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.6323Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01553Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.0008581InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.001959InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.004096InformativeInherited
Mammalian Phenotype (MP)decreased cholesterol level0.00009389Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000000000009802Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1669Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.261Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000003046Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.000004802Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.3002Moderately InformativeInherited
Worm Phenotype (WP)small0.000000008524InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.000002699InformativeDirect
Worm Phenotype (WP)odorant chemosensory response variant0.0000158InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003262InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0Highly InformativeDirect
Worm Phenotype (WP)body vacuole0Highly InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)pericellular component physiology variant0.00000000005748Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.00000000008515Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.000000004119Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis defective0.000008427Highly InformativeDirect
Worm Phenotype (WP)epithelial system physiology variant0.000009071Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.002295Highly InformativeInherited
Worm Phenotype (WP)alae morphology variant0.1348Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0Least InformativeDirect
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.02569Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.004583InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0005797Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.09166Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.4496Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.529Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.6545Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6912Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.19Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.235Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.3334Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5742Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.0001767InformativeDirect
Zebrafish Anatomy (ZA)muscle cell0.0149InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.04359InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.06334InformativeInherited
Zebrafish Anatomy (ZA)eye0.1098InformativeInherited
Zebrafish Anatomy (ZA)suspensorium0.001219Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch 2 skeleton0.003201Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.008351Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal neural layer0.00901Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000003303Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.00000000004223Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000000000201InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]