SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Superfamily statistics
Genomes (2,965) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 38,206 341,257 4
Proteins 21,625 194,271 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethylglutaryl-CoA reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.005037Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0.0001889InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1757Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2229Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.06392Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.09884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1011Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.006599InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.01113InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.01136InformativeInherited
Phenotypic Abnormality (PA)Iris coloboma0.0001333Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal distal phalanx morphology of finger0.0001985Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the phalanges of the hand0.0005714Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal hand morphology0.002125Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.004653Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.006763Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.6322Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01555Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.0008584InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.00196InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.004095InformativeInherited
Mammalian Phenotype (MP)decreased cholesterol level0.000094Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000000000007776Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1379Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.2784Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2789Least InformativeInherited
Worm Phenotype (WP)adult body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000004031Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.5827Moderately InformativeInherited
Worm Phenotype (WP)movement variant1Moderately InformativeInherited
Worm Phenotype (WP)small0.000000009207InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.000002553InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.1359InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0Highly InformativeDirect
Worm Phenotype (WP)body vacuole0Highly InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.00000000008367Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.00000000387Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.002312Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.05215Highly InformativeInherited
Worm Phenotype (WP)alae morphology variant0.1387Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0279Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.005269InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0006331Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.0901Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.4612Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.5315Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6925Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.795Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.04187Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1965Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.2343Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.3376Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.58Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.0001829InformativeDirect
Zebrafish Anatomy (ZA)muscle cell0.01525InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.04489InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.06355InformativeInherited
Zebrafish Anatomy (ZA)eye0.1136InformativeInherited
Zebrafish Anatomy (ZA)suspensorium0.001231Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch 2 skeleton0.003296Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.008521Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal neural layer0.009432Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000003344Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.00000000004316Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000000002059InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]