SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinases, catalytic subunit family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Family:   Protein kinases, catalytic subunit [ 88854] (63)


Family statistics
Genomes (1,856) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 125,827 372,019 219
Proteins 124,451 368,132 219


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0002171Least InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0.004771Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.0132Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.02787Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.07784Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1881Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2076Moderately InformativeInherited
Disease Ontology (DO)retinal cell cancer0.000003616InformativeDirect
Disease Ontology (DO)malignant glioma0.00005245InformativeDirect
Disease Ontology (DO)large intestine cancer0.00006202InformativeDirect
Disease Ontology (DO)liver carcinoma0.0001792InformativeDirect
Disease Ontology (DO)lung carcinoma0.0002352InformativeDirect
Disease Ontology (DO)male reproductive organ cancer0.01553InformativeInherited
Disease Ontology (DO)parasitic infectious disease0.8646InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9474InformativeInherited
Disease Ontology (DO)synostosis0.0004391Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0004504Highly InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.1026Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Incomplete penetrance0.0002171Moderately InformativeDirect
Mode of Inheritance (MI)Autosomal dominant inheritance0.0005868Least InformativeDirect
Mode of Inheritance (MI)Somatic mutation0.00002075Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1187Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.000179Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal heart morphology0.5422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.005811InformativeInherited
Phenotypic Abnormality (PA)Atrial septal defect0.00007045Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000202Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000137Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0001056Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0004352Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0791Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0000004568Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00018Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003592Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.03799Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07715Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.8932Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00004948InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.00018InformativeDirect
Mammalian Phenotype (MP)abnormal heart layer morphology0.002681InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.05718InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.2347InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.4237InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.00006468Highly InformativeDirect
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0003188Highly InformativeDirect
Mammalian Phenotype (MP)sex reversal0.0003283Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.6633Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0.0003084Least InformativeDirect
Worm Phenotype (WP)cell development variant0.007958Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06032Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0685Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1278Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.1278Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000001188Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.000001339Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.001759Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.002352Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.04472Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05175Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1028Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.2797Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.3397Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.375Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4902Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.5009Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.7779Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.7779Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.7802Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.7828Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.8226Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant1Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0000001094InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001408InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0005021InformativeDirect
Worm Phenotype (WP)metal response variant0.0008607InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0009117InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0017InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.00689InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.006974InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.02191InformativeInherited
Worm Phenotype (WP)egg laying variant0.06357InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1955InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2042InformativeInherited
Worm Phenotype (WP)vulva development variant0.2412InformativeInherited
Worm Phenotype (WP)drug resistant0.2714InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.306InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.7367InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.7538InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.834InformativeInherited
Worm Phenotype (WP)cell number increased0.8531InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9234InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.0000000004748Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000004418Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000001273Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.000001388Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00003216Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00007648Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.000316Highly InformativeDirect
Worm Phenotype (WP)excretory secretory system development variant0.0009142Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000966Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.003482Highly InformativeInherited
Worm Phenotype (WP)intestinal development variant0.05373Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.1631Highly InformativeInherited
Worm Phenotype (WP)aqueous positive chemotaxis variant0.2693Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant0.8898Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9436Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.2623Least InformativeInherited
Yeast Phenotype (YP)metabolism and growth0.4557Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9501InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.000005507Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000009263Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.000009695Highly InformativeDirect
Yeast Phenotype (YP)cell death0.0002214Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.03004Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.00002894Moderately InformativeDirect
Fly Phenotype (FP)visible0.00002944Moderately InformativeDirect
Fly Phenotype (FP)size defective0.0000000006519InformativeDirect
Fly Phenotype (FP)wild-type0.0000002844InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.00001387InformativeDirect
Fly Phenotype (FP)cell death defective0.00002216InformativeDirect
Fly Phenotype (FP)planar polarity defective0.000258InformativeDirect
Fly Phenotype (FP)cell cycle defective0.0002801InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0007534InformativeDirect
Fly Phenotype (FP)increased occurrence of cell division0.000004941Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.0003162Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0008137Highly InformativeDirect
Fly Phenotype (FP)stress response defective0.03094Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.003053Least InformativeInherited
Fly Anatomy (FA)nervous system0.00583Least InformativeInherited
Fly Anatomy (FA)tagma0.01165Least InformativeInherited
Fly Anatomy (FA)anatomical group0.01554Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02278Least InformativeInherited
Fly Anatomy (FA)adult0.03005Least InformativeInherited
Fly Anatomy (FA)larva0.04782Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2918Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0004601Moderately InformativeDirect
Fly Anatomy (FA)female organism0.006757Moderately InformativeInherited
Fly Anatomy (FA)gonad0.007588Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.008899Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.02778Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03216Moderately InformativeInherited
Fly Anatomy (FA)neuron0.046Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0516Moderately InformativeInherited
Fly Anatomy (FA)adult head0.06086Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1142Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.211Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.2165Moderately InformativeInherited
Fly Anatomy (FA)cell component0.0002856InformativeDirect
Fly Anatomy (FA)somatic cell of ovariole0.000599InformativeDirect
Fly Anatomy (FA)midgut0.03057InformativeInherited
Fly Anatomy (FA)adult head sensillum0.03216InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.07482InformativeInherited
Fly Anatomy (FA)adult peripheral nervous system0.08279InformativeInherited
Fly Anatomy (FA)somatic stem cell0.1105InformativeInherited
Fly Anatomy (FA)sensory organ cell0.1516InformativeInherited
Fly Anatomy (FA)eye0.173InformativeInherited
Fly Anatomy (FA)photoreceptor cell0.3015InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.4763InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.4863InformativeInherited
Fly Anatomy (FA)epithelial tube0.8215InformativeInherited
Fly Anatomy (FA)intestinal stem cell0.0009774Highly InformativeDirect
Fly Anatomy (FA)inner photoreceptor cell0.4448Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.06613Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1819Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.4025InformativeInherited
Zebrafish Anatomy (ZA)integument0.3568Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1025Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.3855Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.988Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00002195InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.01195InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.0001598Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1476Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]