SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Netrin-like domain (NTR/C345C module) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   TIMP-like [ 50242] (3)
Family:   Netrin-like domain (NTR/C345C module) [ 89320] (2)


Family statistics
Genomes (57) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 105 210 2
Proteins 105 209 2


Disease Ontology (DO)

(
show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0007261Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0009358Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001663Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.002663Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01705Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.00000317InformativeDirect
Disease Ontology (DO)psoriasis0.000008923InformativeDirect
Disease Ontology (DO)asthma0.00009631InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0001013InformativeDirect
Disease Ontology (DO)proteinuria0.0000001884Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1999Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0Moderately InformativeDirect
Phenotypic Abnormality (PA)Unusual infection0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of complement system0InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.002619InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1513Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.001033Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0002243InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0005661InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to bacterial infection0.0001009Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TIMP-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]