SUPERFAMILY 1.75 HMM library and genome assignments server

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DNA replication initiator (cdc21/cdc54) N-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   Nucleic acid-binding proteins [ 50249] (16)
Family:   DNA replication initiator (cdc21/cdc54) N-terminal domain [ 89332]


Family statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 134 873 1
Proteins 134 873 1


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.004737Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02091Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.02156Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.02734Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.00002989Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0.0002667Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.01607Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.0615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1857Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3016Moderately InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.00002661InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.0001124InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.02548InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.00000000000002359Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.000002393Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality, incomplete penetrance0.0002448Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0003569Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0005098Least InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.000001283Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.00004119Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.00007378Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0004516Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0004885Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001011Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.009514Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01276Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.000000001696InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000001006InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.00000005109InformativeDirect
Worm Phenotype (WP)gonad development variant0.00000342InformativeDirect
Worm Phenotype (WP)drug hypersensitive0.00002433InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.00007308InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.002776InformativeInherited
Worm Phenotype (WP)multiple nuclei0.00000002068Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000000266Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.00000005667Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.0000003427Highly InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.00006623Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001391Highly InformativeInherited
Worm Phenotype (WP)nuclear appearance number defective early emb0.001437Highly InformativeInherited
Worm Phenotype (WP)nucleus defective early emb0.001437Highly InformativeInherited
Worm Phenotype (WP)pronuclear morphology defective early emb0.001437Highly InformativeInherited
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.001581Highly InformativeInherited
Worm Phenotype (WP)cytoplasmic appearance variant0.006804Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 186 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nucleic acid-binding proteins domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]