SUPERFAMILY 1.75 HMM library and genome assignments server

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Notch domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Notch domain [ 90192]
Superfamily:   Notch domain [ 90193]
Family:   Notch domain [ 90194]


Family statistics
Genomes (0) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 0 0 0
Proteins 0 0 0


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.04754Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00004391Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0001396Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.001161Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.002647Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.019Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.0000005419InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.00001403InformativeDirect
Disease Ontology (DO)urinary system cancer0.00001478InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.00002466InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002718InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.0004663InformativeDirect
Disease Ontology (DO)skin hemangioma0.0000000000001514Highly InformativeDirect
Disease Ontology (DO)hemangioma0.000000001805Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.000000009519Highly InformativeDirect
Disease Ontology (DO)purpura0.000001628Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.7882Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Localized skin lesion0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Unusual infection0.005005Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.02222Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.02943Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.05684Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1903Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.3734Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0InformativeDirect
Phenotypic Abnormality (PA)Hernia0InformativeDirect
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.000561InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0005686InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.0007046InformativeDirect
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.001125InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.003833InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.007964InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.01964InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.03414InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fontanelles or cranial sutures0.09451InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.1683InformativeInherited
Phenotypic Abnormality (PA)Hernia of the abdominal wall0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.000147Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.000188Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital malformation of the great arteries0.0003246Highly InformativeDirect
Phenotypic Abnormality (PA)Kyphosis0.0005525Highly InformativeDirect
Phenotypic Abnormality (PA)Increased blood pressure0.0005525Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.001399Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.006741Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01081Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.02734Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02943Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.0001055Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0001832Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin morphology0.0002078Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0006105Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.0007131Moderately InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.0007223Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.001055Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.002006Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.005016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.007108Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.008142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.07411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.08391Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1983Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.2007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.4111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4606Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.000008544InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0001155InformativeDirect
Mammalian Phenotype (MP)abnormal placenta morphology0.0002111InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0002699InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0003276InformativeDirect
Mammalian Phenotype (MP)abnormal lymph organ size0.005613InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.006204InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme level0.01261InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.03124InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.05198InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.07329InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2002InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.000001954Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.000003658Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney size0.0002087Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.0007437Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.003903Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Notch domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]