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Myosin rod fragments superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Myosin rod fragments [ 90257]
Families:   Myosin rod fragments [ 90258] (2)


Superfamily statistics
Genomes (685) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,319 34,780 6
Proteins 4,103 15,049 4


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)intrinsic cardiomyopathy0.002903InformativeInherited
Disease Ontology (DO)dilated cardiomyopathy0.0006927Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01686Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1162Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2142Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3286Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.33Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.69Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.00926Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.02779Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.08704Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1698Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1716Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.5264Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.001275InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01922InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.02128InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.04683InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.06432InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1599InformativeInherited
Phenotypic Abnormality (PA)Scapular winging0.0003266Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0005746Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal left ventricle morphology0.0006364Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.0009592Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0009849Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0263Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7302Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003943InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1134InformativeInherited
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.0001678Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.0005147Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.03507Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.03811Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.04701Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.1014Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1015Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1387Least InformativeInherited
Worm Phenotype (WP)movement variant0.006425Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.04228Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.3156Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002163InformativeDirect
Worm Phenotype (WP)drug resistant0.0006244InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0008437InformativeDirect
Worm Phenotype (WP)locomotion reduced0.001121InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.0000000695Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00003498Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.09454Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0588Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1498Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.0001326InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3483Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6151Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05814Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01883InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.005542Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000008845Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000001259InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin rod fragments domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Myosin rod fragments superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]