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Myosin rod fragments superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Myosin rod fragments [ 90257]
Families:   Myosin rod fragments [ 90258] (2)


Superfamily statistics
Genomes (685) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,319 34,780 6
Proteins 4,103 15,049 4


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cardiovascular system disease0.06996Least InformativeInherited
Disease Ontology (DO)intrinsic cardiomyopathy0.002962InformativeInherited
Disease Ontology (DO)dilated cardiomyopathy0.0006921Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01527Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1106Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.223Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3238Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3264Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.009383Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.08539Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1606Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.001346InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.01874InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02544InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.03437InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1604InformativeInherited
Phenotypic Abnormality (PA)Scapular winging0.0003386Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0006087Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0009653Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02638Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7306Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003948InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1131InformativeInherited
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.0001677Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.0005159Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.03285Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0454Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.08372Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08414Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.002426Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01555Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000201InformativeDirect
Worm Phenotype (WP)drug resistant0.0005244InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0008132InformativeDirect
Worm Phenotype (WP)locomotion reduced0.001065InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.00000006449Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00003308Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.09078Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.05103Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1486Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.000129InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3415Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6163Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05488Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01838InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.005544Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000008761Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000001251InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin rod fragments domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Myosin rod fragments superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]