SUPERFAMILY 1.75 HMM library and genome assignments server

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Sema domain alignments in Homo sapiens 69_37

These alignments are sequences aligned to the 0048597 model.

Sophisticated options are available for refining alignments:


Jump to [ Top of page · Refine alignments · Add alignments from genomes ]

Alignments

The numbers along the top are the segment numbers of the HMM states, and each sequence is seperately aligned to the model.
The first sequence is the seed the model was built from.
Upper case letters are aligned, lower case letters are insertions, '-' signifies a deletion and '.' is nothing.

                                                                                                    
                                                                                                    
d1olza2            fa...............................................................................
ENSP00000265362  nvprl............................................................................
ENSP00000284136  niprl............................................................................
ENSP00000466308  prlrlsfqelqa.....................................................................
ENSP00000411193  r................................................................................
ENSP00000303212  hprl.............................................................................
ENSP00000398399  tprv.............................................................................
ENSP00000388768  pi...............................................................................
ENSP00000306844  vssge............................................................................
ENSP00000332204  islp.............................................................................
ENSP00000231721  vprl.............................................................................
ENSP00000398776  kyqlpnftaetpiqnvil...............................................................
ENSP00000374083  gne..............................................................................
ENSP00000282394  rhrl.............................................................................
ENSP00000342675  rts..............................................................................
ENSP00000301293  rdyl.............................................................................
ENSP00000357266  ra...............................................................................
ENSP00000359270  mtipyee..........................................................................
ENSP00000417570  lqp..............................................................................
ENSP00000371936  ykeigp...........................................................................
ENSP00000357908  dlqgtsplswfrgleddavaaelg.........................................................
ENSP00000251772  tf...............................................................................
ENSP00000323194  vt...............................................................................
ENSP00000356000  st...............................................................................
ENSP00000358696  fvvt.............................................................................
ENSP00000352288  kld..............................................................................
ENSP00000296440  ft...............................................................................
ENSP00000296474  kyvvpsfsagglvqamv................................................................
ENSP00000261918  drvd.............................................................................
ENSP00000317128  qrr..............................................................................
ENSP00000445569  rfs..............................................................................
ENSP00000258526  pvwrseqaigaiaasqedgvfvasgscldqldyslehslsrlyrdqagnctepvslapparprpgssfsklllpyregaag


                                                                                                    
                                                                                                    
d1olza2            .................................................................................
ENSP00000265362  .................................................................................
ENSP00000284136  .................................................................................
ENSP00000466308  .................................................................................
ENSP00000411193  .................................................................................
ENSP00000303212  .................................................................................
ENSP00000398399  .................................................................................
ENSP00000388768  .................................................................................
ENSP00000306844  .................................................................................
ENSP00000332204  .................................................................................
ENSP00000231721  .................................................................................
ENSP00000398776  .................................................................................
ENSP00000374083  .................................................................................
ENSP00000282394  .................................................................................
ENSP00000342675  .................................................................................
ENSP00000301293  .................................................................................
ENSP00000357266  .................................................................................
ENSP00000359270  .................................................................................
ENSP00000417570  .................................................................................
ENSP00000371936  .................................................................................
ENSP00000357908  .................................................................................
ENSP00000251772  .................................................................................
ENSP00000323194  .................................................................................
ENSP00000356000  .................................................................................
ENSP00000358696  .................................................................................
ENSP00000352288  .................................................................................
ENSP00000296440  .................................................................................
ENSP00000296474  .................................................................................
ENSP00000261918  .................................................................................
ENSP00000317128  .................................................................................
ENSP00000445569  .................................................................................
ENSP00000258526  lggllltgwtfdrgacevrplgnlsrnslrngtevvschpqgstagvvyragrnnrwylavaatyvlpepetasrcnpaas


                                                                                                    
                                                                                                    
d1olza2            .................................................................................
ENSP00000265362  .................................................................................
ENSP00000284136  .................................................................................
ENSP00000466308  .................................................................................
ENSP00000411193  .................................................................................
ENSP00000303212  .................................................................................
ENSP00000398399  .................................................................................
ENSP00000388768  .................................................................................
ENSP00000306844  .................................................................................
ENSP00000332204  .................................................................................
ENSP00000231721  .................................................................................
ENSP00000398776  .................................................................................
ENSP00000374083  .................................................................................
ENSP00000282394  .................................................................................
ENSP00000342675  .................................................................................
ENSP00000301293  .................................................................................
ENSP00000357266  .................................................................................
ENSP00000359270  .................................................................................
ENSP00000417570  .................................................................................
ENSP00000371936  .................................................................................
ENSP00000357908  .................................................................................
ENSP00000251772  .................................................................................
ENSP00000323194  .................................................................................
ENSP00000356000  .................................................................................
ENSP00000358696  .................................................................................
ENSP00000352288  .................................................................................
ENSP00000296440  .................................................................................
ENSP00000296474  .................................................................................
ENSP00000261918  .................................................................................
ENSP00000317128  .................................................................................
ENSP00000445569  .................................................................................
ENSP00000258526  dhdtaialkdtegrslatqelgrlklcegagslhfvdaflwngsiyfpyypynytsgaatgwpsmariaqstevlfqgqas


                                                   10        20        30        40        50       
                                                    |         |         |         |         |       
d1olza2            ........................--PIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISE
ENSP00000265362  ........................--KLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNI-K
ENSP00000284136  ........................--KLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNK
ENSP00000466308  ........................------------WHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISK
ENSP00000411193  ........................-VYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQ
ENSP00000303212  ........................--RLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISD
ENSP00000398399  ........................--RLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINR
ENSP00000388768  ........................----PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISE
ENSP00000306844  ........................-----------LATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALEL
ENSP00000332204  ........................--------LGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFL
ENSP00000231721  ........................--RLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWP
ENSP00000398776  ........................----------------------------------HEHHIFLGATNYIYVLNEED--L
ENSP00000374083  ........................----------------------SQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPK
ENSP00000282394  ........................---------------------------DIQMIMIMNGTLYIAARDHIYTVDIDTSHT
ENSP00000342675  ........................------LPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGE
ENSP00000301293  ........................----NHYPVFVGSGPGRLTPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTS
ENSP00000357266  ........................---------------LSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGV
ENSP00000359270  ........................-------------LSGTRHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGD
ENSP00000417570  ........................--------------WVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSL
ENSP00000371936  ........................--------------WLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL
ENSP00000357908  ........................--------------------------LDFQRFLTLNRTLLVAARDHVFSFDLQAEEE
ENSP00000251772  ........................--------------------SASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGN---L
ENSP00000323194  ........................------------------FRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSD---L
ENSP00000356000  ........................-----------------FHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGN---L
ENSP00000358696  ........................-----------------------DTTLTHLAVHRVTGEVFVGAVNRVFKLAPN---L
ENSP00000352288  ........................-------------------FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAK---L
ENSP00000296440  ........................---------------------PNGTYLQHLARDPTSGTLYLGATNFLFQLSPG---L
ENSP00000296474  ........................----------------------------TYEGDRNESAVFVAIRNRLHVLGPD---L
ENSP00000261918  ........................--------------------FGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKN
ENSP00000317128  ........................--------------------FPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSL
ENSP00000445569  ........................---------------------APNTTLNHLALAPGRGTLYVGAVNRLFQLSPE---L
ENSP00000258526  ldcghghpdgrrlllssslveald---------------------------------------------------------


                        60        70                 80           90         100       110       120
                         |         |                  |            |           |         |         |
d1olza2            K....QHEVYWKVSEDKK..AKCAEK.......GKSKQ...TECLNYIRVLQPLS..ATSLYVCGTNAFQPACDHLNLTSF
ENSP00000265362  D....FQKIVWPVSYTRR..DECKWA.......GKDIL...KECANFIKVLKAYN..QTHLYACGTGAFHPICTYIEIGHH
ENSP00000284136  N....FKKIYWPAAKERV..ELCKLA.......GKDAN...TECANFIRVLQPYN..KTHIYVCGTGAFHPICGYIDLGVY
ENSP00000466308  R....AKKLAWPAPVEWR..EECNWA.......GKDIG...TECMNFVKLLHAYN..RTHLLACGTGAFHPTCAFVEVGHR
ENSP00000411193  E....ALSVFWPASTIKV..EECKMA.......GKDPT...HGCGNFVRVIQTFN..RTHLYVCGSGAFSPVCTYLNRGRR
ENSP00000303212  G....YKEIHWPSTALKM..EECIMK.......GKDAG...-ECANYVRVLHHYN..RTHLLTCGTGAFDPVCAFIRVGYH
ENSP00000398399  E....PLIIHWAASPQRI..EECVLS.......GKDVN...GECGNFVRLIQPWN..RTHLYVCGTGAYNPMCTYVNRGRR
ENSP00000388768  K....QHEVYWKVSEDKK..AKCAEK.......GKSKQ...TECLNYIRVLQPLS..ATSLYVCGTNAFQPACDHLNLTSF
ENSP00000306844  -....QGAISWEAPVEKK..TECIQK.......GKNNQ...TECFNFIRFLQPYN..ASHLYVCGTYAFQPKCTYVNMLTF
ENSP00000332204  Pgge.YQELLWGADAEKK..QQCSFK.......GKDPQ...RDCQNYIKILLPLS..GSHLFTCGTAAFSPMCTYINMENF
ENSP00000231721  D....PREVLWPPQPGQR..EECVRK.......GRDPL...TECANFVRVLQPHN..RTHLLACGTGAFQPTCALITVGHR
ENSP00000398776  Q....KVAEYKTGPVLEH..PDCFPCqdcsskaN---LsggVWKDNINMALVVDTyyDDQLISCGS-VNRGTCQRHVFPHN
ENSP00000374083  TevipNKKLTWRSRQQDR..ENCAMK.......GKHKD...-ECHNFIKVFVPRN..DEMVFVCGTNAFNPMCRYYRLSTL
ENSP00000282394  EeiycSKKLTWKSRQADV..DTCRMK.......GKHKD...-ECHNFIKVLLKKN..DDALFVCGTNAFNPSCRNYKMDTL
ENSP00000342675  R....PRRIDWMVPEAHR..QNCRKK.......GKKED...-ECHNFVQILAIAN..ASHLLTCGTFAFDPKCGVIDVSRF
ENSP00000301293  TelryQRKLTWRSNPSDI..NVCRMK.......GKQEG...-ECRNFVKVLLLRD..ESTLFVCGSNAFNPVCANYSIDTL
ENSP00000357266  Prl..KNMIPWPASDRKK..SECAFK.......KKSNE...TQCFNFIRVLVSYN..VTHLYTCGTFAFSPACTFIELQDS
ENSP00000359270  Ga...HKEIHWEASPEMQ..SKCHQK.......GKNNQ...TECFNHVRFLQRLN..STHLYACGTHAFQPLCAAIDAEAF
ENSP00000417570  -....LQATEWASSEDTR..RSCQSK.......GKTEE...-ECQNYVRVLIVAG..RK-VFMCGTNAFSPMCTSRQVGNL
ENSP00000371936  -....IQAVEWECDEATK..KACYSK.......GKSKE...-ECQNYIRVLLVGG..DR-LFTCGTNAFTPVCTNRSLSNL
ENSP00000357908  Gegl.VPNKYLTWRSQDV..ENCAVR.......GKLTD...-ECYNYIRVLVPWD..SQTLLACGTNSFSPVCRSYGITSL
ENSP00000251772  T....LLRAHVTGPVEDN..EKCYPPpsvqs..CPHGL...GSTDNVNKLLLLDYa.ANRLLACGS-ASQGICQFLRLDDL
ENSP00000323194  K....VLVTHETGPDEDN..PKCYPPrivqt..CNEPL...TTTNNVNKMLLIDYk.ENRLIACGS-LYQGICKLLRLEDL
ENSP00000356000  T....IQVAHKTGPEEDN..KSCYPPlivqp..CSEVL...TLTNNVNKLLIIDYs.ENRLLACGS-LYQGVCKLLRLDDL
ENSP00000358696  T....ELRAHVTGPVEDN..ARCYPPpsmrv..CAHRL...APVDNINKLLLIDYa.ARRLVACGS-IWQGICQFLRLDDL
ENSP00000352288  Q....LEQQVATGPALDN..KKCTPPieas...QCHEA...EMTDNVNQLLLLDPp.RKRLVECGS-LFKGICALRALSNI
ENSP00000296440  Q....LEATVSTGPVLDS..RDCLPPvmpd...ECPQA...QPTNNPNQLLLVSP..GA-LVVCGS-VHQGVCEQRRLGQL
ENSP00000296474  K....SVQSLATGPAGDPgcQTCAAC.......GPGPHg..PPGDTDTKVLVLDPa.LPALVSCGS-SLQGRCFLHDLEPQ
ENSP00000261918  A....SVRTVNIGS----..---TKG.......SCLDK...RDCENYITLLERRS..EG-LLACGTNARHPSCWNLVNGTV
ENSP00000317128  -....-EAEAAVGPVPDS..PLCHAPqlpqas.CEHPR...RLTDNYNKILQLDPg.QGLVVVCGS-IYQGFCQLRRRGNI
ENSP00000445569  Q....LEAVAVTGPVIDS..PDCVPFrdpa...ECPQA...QLTDNANQLLLVSSr.AQELVACGQ-VRQGVCETRRLGDV
ENSP00000258526  -....-------------..------.......-----...--------------..------------------------


                                                                130       140                     15
                                                                  |         |                       
d1olza2            KFL......................................GKNEDGKGRCPFDPAHSYTSVMV.......DG.......E
ENSP00000265362  PEDnifklen...............................SHFENGRGKSPYDPKLLTASLLI.......DG.......E
ENSP00000284136  KEDiifkldt...............................HNLESGRLKCPFDPQQPFASVMT.......DE.......Y
ENSP00000466308  AEEpvlrldp...............................GRIEDGKGKSPYDPRHRAASVLV.......GE.......E
ENSP00000411193  SEDqvfmid................................SKCESGKGRCSFNPNVNTVSVMI.......NE.......E
ENSP00000303212  LEDplfhles...............................PRSERGRGRCPFDPSSSFISTLI.......GS.......E
ENSP00000398399  AQAtpwtqtqavrgrgsratdgalrpmptaprqdyifylepERLESGKGKCPYDPKLDTASALI.......NE.......E
ENSP00000388768  KFL......................................GKNEDGKGRCPFDPAHSYTSVMV.......DG.......E
ENSP00000306844  TLEh.....................................GEFEDGKGKCPYDPAKGHAGLLV.......DG.......E
ENSP00000332204  TLArdekgn................................VLLEDGKGRCPFDPNFKSTALVV.......DG.......E
ENSP00000231721  GEHvlhlep................................GSVESGRGRCPHEPSRPFASTFI.......DG.......E
ENSP00000398776  HTAdiqsevhcif............................SPQIEEPSQCPDCVVSALGAKVL.......SSvkdrfi.N
ENSP00000374083  EYD......................................GEEISGLARCPFDARQTNVALFA.......DG.......K
ENSP00000282394  EPF......................................GDEFSGMARCPYDAKHANVALFA.......DG.......K
ENSP00000342675  QQV......................................ERLESGRGKCPFEPAQRSAAVMA.......GG.......V
ENSP00000301293  QPV......................................GDNISGMARCPYDPKHANVALFS.......DG.......M
ENSP00000357266  YLLpise..................................DKVMEGKGQSPFDPAHKHTAVLV.......DG.......M
ENSP00000359270  TLP......................................TSFEEGKEKCPYDPARGFTGLII.......DG.......G
ENSP00000417570  SRT......................................IEKINGVARCPYDPRHNSTAVISs......QG.......E
ENSP00000371936  TEI......................................HDQISGMARCPYSPQHNSTALLTa......GG.......E
ENSP00000357908  QQE......................................GEELSGQARCPFDATQSNVAIFA.......EG.......S
ENSP00000251772  FKLge....................................PHHRKEHYLSSVQEAGSMAGVLI.......AGppgqgqaK
ENSP00000323194  FKLge....................................PYHKKEHYLSGVNESGSVFGVIVsysnl..DD.......K
ENSP00000356000  FILve....................................PSHKKEHYLSSVNKTGTMYGVIVrsege..DG.......K
ENSP00000358696  FKLge....................................PHHRKEHYLSGAQEPDSMAGVIV.......EQgqgps..K
ENSP00000352288  SLRlfye..................................DGSGEKSFVASNDEGVATVGLVSstgpgg.DR.......V
ENSP00000296440  EQLllrp..................................ERPGDTQYVAANDPAVSTVGLVA.......QGlagep..L
ENSP00000296474  GTAvhlaapaclfsah.........................HNRPDDCPDCVASPLGTRVTVVE.......QGqas....Y
ENSP00000261918  VP-......................................--LGEMRGYAPFSPDENSLVLFE.......GD.......E
ENSP00000317128  SAVavrfppaappaepv........................TVFPSMLNVAANHPNASTVGLVLppaagagGS.......R
ENSP00000445569  AEVlyqa..................................EDPGDGQFVAANTPGVATVGLVVplpg...RD.......L
ENSP00000258526  ---......................................-----------------------.......--.......-


                   0             160       170                                           180        
                   |               |         |                                             |        
d1olza2            LYSGTSY......NFLGSEPIISRNSS..HS..................................PLRTEYAIPWLNEPS.
ENSP00000265362  LYSGTAA......DFMGRDFAIFRTLGhhHP..................................IRTEQHDSRWLNDPK.
ENSP00000284136  LYSGTAS......DFLGKDTAFTRSLG..PThdhhy.............................IRTDISEHYWLNGAK.
ENSP00000466308  LYSGVAA......DLMGRDFTIFRSLGqrPS..................................LRTEPHDSRWLNEPK.
ENSP00000411193  LFSGMYI......DFMGTDAAIFRSLT..KRna................................VRTDQHNSKWLSEPM.
ENSP00000303212  LFAGLYS......DYWSRDAAIFRSMGrlAH..................................IRTEHDDERLLKEPK.
ENSP00000398399  LYAGVYI......DFMGTDAAIFRTLG..KQta................................MRTDQYNSRWLNDPS.
ENSP00000388768  LYSGTSY......NFLGSEPIISRNSS..HS..................................PLRTEYAIPWLNEPS.
ENSP00000306844  LYSATLN......NFLGTEPIILRNMGp.HH..................................SMKTEYLAFWLNEPH.
ENSP00000332204  LYTGTVS......SFQGNDPAISRSQS..LR..................................PTKTESSLNWLQDPA.
ENSP00000231721  LYTGLTA......DFLGREAMIFRSGGp.RP..................................ALRSDSDQSLLHDPR.
ENSP00000398776  FFVGNTIn.....SSYFPDHPLHSISV..RR..................................LKETKDGFMFLTDQS.
ENSP00000374083  LYSATVA......DFLASDAVIYRSMG..DGsa................................LRTIKYDSKWIKEPH.
ENSP00000282394  LYSATVT......DFLAIDAVIYRSLGesPT..................................LRTVKHDSKWLKEPY.
ENSP00000342675  LYAATVK......NYLGTEPIITRAVGraED..................................WIRTDTLPSWLNAPA.
ENSP00000301293  LFTATVT......DFLAIDAVIYRSLG..DRpt................................LRTVKHDSKWFKEPY.
ENSP00000357266  LYSGTMN......NFLGSEPILMRTLGs.QP..................................VLKTDNFLRWLHHDAs
ENSP00000359270  LYTATRY......EFR-SIPDIRRSRHp.HS..................................LRTEETPMHWLNDAE.
ENSP00000417570  LYAATVI......DFSGRDPAIYRSLGsgPP..................................LRTAQYNSKWLNEPN.
ENSP00000371936  LYAATAM......DFPGRDPAIYRSLGilPP..................................LRTAQYNSKWLNEPN.
ENSP00000357908  LYSATAA......DFQASDAVVYRSLGpqPP..................................LRSAKYDSKWLREPH.
ENSP00000251772  LFVGTPId.....GKSEYFPTLSSRRLm.ANeedadmfgf.........................VYQDEFVSSQLKIPS.
ENSP00000323194  LFIATAVd.....GKPEYFPTISSRKL..TK..................................NSEADGMFAYVFHDE.
ENSP00000356000  LFIGTAVd.....GKQDYFPTLSSRKL..PRdpessa............................M------LDYELHSD.
ENSP00000358696  LFVGTAVd.....GKSEYFPTLSSRKLi.SD..................................EDSADMFSLVYQD-E.
ENSP00000352288  LFVGKGN......GPHDNGIIVSTRLL..DRtdsreafeaytd......................HATYKAGYLSTNTQQ.
ENSP00000296440  LFVGRGYtsr...GVGGGIPPITTRAL..WP..................................PDPQAAFSYEETAKL.
ENSP00000296474  FYVASSLdaavaaSFSPRSVSIRRLKA..DA..................................SGF---------APG.
ENSP00000261918  VYSTIRKq.....EYNGKIPRFRRIRG..ES..................................ELYT--SDTVMQNPQ.
ENSP00000317128  LLVGATY......TGYGSSFFPRNRSL..EDhrfentpeiairsldtrgdlaklftfdlnpsddnILKIKQGAKEQHKLG.
ENSP00000445569  LLVARGLag....KLSAGVPPLAIRQL..AG..................................---SQPFSSEGLGRL.
ENSP00000258526  -------......--------------..--..................................---------------.


                   190                   200       210             220       230       240         2
                     |                     |         |               |         |         |          
d1olza2            FVFADV............IRKSPDSPDGEDDRVYFFFTEVSVE......YEFVFRVLIPRIARVCKGDQGG.LRTLQ.KKW
ENSP00000265362  FISAHL............ISESD---NPEDDKVYFFFRENAID......GEHSGKATHARIGQICKNDFGG.HRSLV.NKW
ENSP00000284136  FIGTFF............IPDTY---NPDDDKIYFFFRESSQE......GSTSDKTILSRVGRVCKNDVGG.QRSLI.NKW
ENSP00000466308  FVKVFW............IPESE---NPDDDKIYFFFRETAVEa.....APALGRLSVSRVGQICRNDVGG.QRSLV.NKW
ENSP00000411193  FVDAHV............IPDGT---DPNDAKVYFFFKEKLTD......NNRSTKQIHSMIARICPNDTGG.LRSLV.NKW
ENSP00000303212  FVGSYM............IPDNE---DRDDNKVYFFFTEKALE......AENNAHAIYTRVGRLCVNDVGG.QRILV.NKW
ENSP00000398399  FIHAEL............IPDSA---ERNDDKLYFFFRERSAE......AP-QSPAVYARIGRICLNDDGG.HCCLV.NKW
ENSP00000388768  FVFADV............IRKSPDSPDGEDDRVYFFFTEVSVE......YEFVFRVLIPRIARVCKGDQGG.LRTLQ.KKW
ENSP00000306844  FVGSAY............VPESVGSFTGDDDKVYFFFRERAVE......SDCYAEQVVARVARVCKGDMGG.ARTLQ.RKW
ENSP00000332204  FVASAY............IPESLGSLQGDDDKIYFFFSETGQE......FEFFENTIVSRIARICKGDEGG.ERVLQ.QRW
ENSP00000231721  FVMAAR............IPENS---DQDNDKVYFFFSETVPSp.....DGGSNHVTVSRVGRVCVNDAGG.QRVLV.NKW
ENSP00000398776  YIDVLPefrds.......YPIKYVHAFESNNFIYFLTVQRETL......D---AQTFHTRIIRFCSIN---.-----.SGL
ENSP00000374083  FLHA--............--------IEYGNYVYFFFREIAVE......HNNLGKAVYSRVARICKNDMGGsQRVLE.KHW
ENSP00000282394  FVQA--............--------VDYGDYIYFFFREIAVE......YNTMGKVVFPRVAQVCKNDMGGsQRVLE.KQW
ENSP00000342675  FVAAVA............LSPAEWGDEDGDDEIYFFFTETSRA......FDSYERIKVPRVARVCAGDLGG.RKTLQ.QRW
ENSP00000301293  FVHA--............--------VEWGSHVYFFFREIAME......FNYLEKVVVSRVARVCKNDVGGsPRVLE.KQW
ENSP00000357266  FVAA--............--------IPSTQVVYFFFEETASE......FDFFERLHTSRVARVCKNDVGG.EKLLQ.KKW
ENSP00000359270  FVFSVL............VRESKASAVGDDDKVYYFFTERATEegsgsfTQSRSSHRVARVARVCKGDLGG.KKILQ.KKW
ENSP00000417570  FVAA--............--------YDIGLFAYFFLRENAVE......HD-CGRTVYSRVARVCKNDVGG.RFLLE.DTW
ENSP00000371936  FVSS--............--------YDIGNFTYFFFRENAVE......HD-CGKTVFSRAARVCKNDIGG.RFLLE.DTW
ENSP00000357908  FVQA--............--------LEHGDHVYFFFREVSVE......DARLGRVQFSRVARVCKRDMGGsPRALD.RHW
ENSP00000251772  D----Tlskfpa......FDIYYVYSFRSEQFVYYLTLQLDTQltsp..DAAGEHFFTSKIVRLCVDD---.-----.PKF
ENSP00000323194  FVASMIkipsdtftiipdFDIYYVYGFSSGNFVYFLTLQPEMVsppg..STTKEQVYTSKLVRLCKED---.-----.TAF
ENSP00000356000  FVSSLIkipsdtlalvshFDIFYIYGFASGGFVYFLTVQPETPegvai.NSAGDLFYTSRIVRLCKDD---.-----.PKF
ENSP00000358696  FVSSQIkipsdtlslypaFDIYYIYGFVSASFVYFLTLQLDTQqtll..DTAGEKFFTSKIVRMCAGD---.-----.SEF
ENSP00000352288  FVAA--............--------FEDGPYVFFVFNQQDKH......P----ARNRTLLARMCRED---.-----.PNY
ENSP00000296440  AVGRLSe...........YSHHFVSAFARGASAYFLFLRRDLQ......A--QSRAFRAYVSRVCLRD---.-----.QHY
ENSP00000296474  FVALSVlpkhlvs.....YSIEYVHSFHTGAFVYFLTVQPASV......TD-DPSALHTRLARLSATE---.-----.PEL
ENSP00000261918  FIKATI............VHQD----QAYDDKIYYFFREDNPD......KNPEAPLNVSRVAQLCRGDQGG.ESSLSvSKW
ENSP00000317128  FVSAFL............HPSD--PPPGAQSYAYLALNSEARA......GD-KESQARSLLARICLPHG-A.GGDAK.KLT
ENSP00000445569  VVGDFSd...........YNNSYVGAFADARSAYFVFRRRGAR......A---QAEYRSYVARVCLGD---.-----.TNL
ENSP00000258526  ------............-------------------------......----------------------.-----.---


                   50       260                270              280                290              
                    |         |                  |                |                  |              
d1olza2            TSFLKARLICSRPDS.........GLVFNVLR.....DVFVLRSP..GL.........KVPVFYALFT..PQLN.......
ENSP00000265362  TTFLKARLICSVPGPngi......DTHFDELQ.....DVFLMNFK..DP.........KNPVVYGVFT..TSSN.......
ENSP00000284136  TTFLKARLICSIPGSdga......DTYFDELQ.....DIYLLPTR..DE.........RNPVVYGVFT..TTSS.......
ENSP00000466308  TTFLKARLVCSVPGVeg.......DTHFDQLRpfpaeDVFLLSSR..DH.........RTPLLYAVFS..TSSS.......
ENSP00000411193  TTFLKARLVCSVTDEdgp......ETHFDELE.....DVFLLETD..NP.........RTTLVYGIFT..TSSS.......
ENSP00000303212  STFLKARLVCSVPGMngi......DTYFDELE.....DVFLLPTR..DH.........KNPVIFGLFN..TTSN.......
ENSP00000398399  STFLKARLVCSVPGEdgi......ETHFDELQ.....DVFVQQTQ..DV.........RNPVIYAVFT..SSGS.......
ENSP00000388768  TSFLKARLICSRPDS.........GLVFNVLR.....DVFVLRSP..GL.........KVPVFYALFT..PQLN.......
ENSP00000306844  TTFLKARLACSAPNW.........QLYFNQLQ.....AMHTLQDT..SW.........HNTTFFGVFQ..AQWG.......
ENSP00000332204  TSFLKAQLLCSRPDD.........GFPFNVLQ.....DVFTLSPSpqDW.........RDTLFYGVFT..SQWHrg.....
ENSP00000231721  STFLKARLVCSVPGPgga......ETHFDQLE.....DVFLLWPK..AG.........KSLEVYALFS..TVSA.......
ENSP00000398776  HSYMEMPLECILTEKrkkrstk..KEVFNILQ.....AAYVSKPG..AQlarqigaslNDDILFGVFA..QSKPdsae...
ENSP00000374083  TSFLKARLNCSVPGDs........FFYFDVLQ.....SITDIIQI..NG.........I-PTVVGVFT..TQLN.......
ENSP00000282394  TSFLKARLNCSVPGDs........HFYFNILQ.....AVTDVIRI..NG.........R-DVVLATFS..TPYN.......
ENSP00000342675  TTFLKADLLCPGPEH.........GRASSVLQ.....DVAVLRPE..LGa........GTPIFYGIFS..SQWE.......
ENSP00000301293  TSFLKARLNCSVPGDs........HFYFNVLQ.....AVTGVVSL..GG.........R-PVVLAVFS..TPSN.......
ENSP00000357266  TTFLKAQLLCTQPG-.........QLPFNVIR.....HAVLLPAD..SP.........TAPHIYAVFT..SQWQvg.....
ENSP00000359270  TSFLKARLICHIPL-.........---YETLR.....GVCSLDAE..TS.........SRTHFYAAFTlsTQWK.......
ENSP00000417570  TTFMKARLNCSRPGEv........PFYYNELQ.....SAFHLPEQ..D-.........---LIYGVFT..TNVN.......
ENSP00000371936  TTFMKARLNCSRPGEv........PFYYNELQ.....STFFLPEL..D-.........---LIYGIFT..TNVN.......
ENSP00000357908  TSFLKLRLNCSVPGDs........TFYFDVLQ.....ALTGPVNL..HG.........R-SALFGVFT..TQTN.......
ENSP00000251772  YSYVEFPIGCEQAGV.........E--YRLVQ.....DAYLSRPG..RAlahqlglaeDEDVLFTVFA..QGQKnrvk...
ENSP00000323194  NSYVEVPIGCERSGV.........E--YRLLQ.....AAYLSKAG..AVlgrtlgvhpDDDLLFTVFS..KGQKrkmk...
ENSP00000356000  HSYVSLPFGCTRAGV.........E--YRLLQ.....AAYLAKPG..DSlaqafnitsQDDVLFAIFS..KGQKqyhh...
ENSP00000358696  YSYVEFPIGCSWRGV.........E--YRLVQ.....SAHLAKPG..LLlaqalgvpaDEDVLFTIFS..QGQKnras...
ENSP00000352288  YSYLEMDLQCRDPDIh........AAAFGTCL.....AASVAAPG..SG.........R--VLYAVFS..RDSRss.....
ENSP00000296440  YSYVELPLACEGGR-.........---YGLIQ.....AAAVATSR..EVa........HGEVLFAAFS..SAAPptvgrpp
ENSP00000296474  GDYRELVLDCRFAPKrrrrgapegGQPYPVLR.....VAHSAPVG..AQlatelsiaeGQEVLFGVFV..TGKDggpg...
ENSP00000261918  NTFLKAMLVCSDAAT.........NKNFNRLQ.....DVFLLPDP..SGqw.......RDTRVYGVFS..NPWN.......
ENSP00000317128  ESYIQLGLQCAGGAGr........GDLYSRLV.....SVFPAR--..--.........--ERLFAVFE..RPQGspaa...
ENSP00000445569  YSYVEVPLACQGQG-.........-----LIQ.....AAFLAP--..--.........--GTLLGVFA..AGPR.......
ENSP00000258526  ---------------.........--------.....--------..--.........---VWAGVFS..AAAGegqerr.


                          300       310       320           330        340       350         360    
                            |         |         |             |          |         |           |    
d1olza2            .....NVGLSAVCAYNLSTAEEVFSHGKYMQSTT....VEQSHTKWVRYN.GPVPKPRPGACIDS..EARAANYTSSLNLP
ENSP00000265362  .....IFKGSAVCMYSMSDVRRVFLGP----YAH....RDGPNYQWVPYQ.GRVPYPRPGTCPSK..--TFGGFDSTKDLP
ENSP00000284136  .....IFKGSAVCVYSMADIRAVFNGP----YAH....KESADHRWVQYD.GRIPYPRPGTCPSK..-TYDPLIKSTRDFP
ENSP00000466308  .....IFQGSAVCVYSMNDVRRAFLGP----FAH....KEGPMHQWVSYQ.GRVPYPRPGMCPSK..--TFGTFSSTKDFP
ENSP00000411193  .....VFKGSAVCVYHLSDIQTVFNGP----FAH....KEGPNHQLISYQ.GRIPYPRPGTCPGG..-AFTPNMRTTKEFP
ENSP00000303212  .....IFRGHAICVYHMSSIRAAFNGP----YAH....KEGPEYHWSVYE.GKVPYPRPGSCASK..-VNGGRYGTTKDYP
ENSP00000398399  .....VFRGSAVCVYSMADIRMVFNGP----FAH....KEGPNYQWMPFS.GKMPYPRPGTCPGG..-TFTPSMKSTKDYP
ENSP00000388768  .....NVGLSAVCAYNLSTAEEVFSHGKYMQSTT....VEQSHTKWVRYN.GPVPKPRPGACIDS..EARAANYTSSLNLP
ENSP00000306844  .....DMYLSAICEYQLEEIQRVFEGP----YKE....YHEEAQKWDRYT.DPVPSPRPGSCINN..WHRRHGYTSSLELP
ENSP00000332204  .....TTEGSAVCVFTMKDVQRVFSGL----YKE....VNRETQQWYTVT.HPVPTPRPGACITN..SARERKINSSLQLP
ENSP00000231721  .....VFQGFAVCVYHMADIWEVFNGP----FAH....RDGPQHQWGPYG.GKVPFPRPGVCPSKmtAQPGRPFGSTKDYP
ENSP00000398776  .....PMDRSAMCAFPIKYVNDFFNKIVN--KNN....VRCLQHFYGPNH.EH--------CFNR..-TLLRNSSGCEARR
ENSP00000374083  .....SIPGSAVCAFSMDDIEKVFKGR----FKE....QKTPDSVWTAVPeDKVPKPRPGCCAKH..-GLAEAYKTSIDFP
ENSP00000282394  .....SIPGSAVCAYDMLDIASVFTGR----FKE....QKSPDSTWTPVPdERVPKPRPGCCAGS..-SSLERYATSNEFP
ENSP00000342675  .....GATISAVCAFRPQDIRTVLNGP----FREl...KHDCNRGLPVVD.NDVPQPRPGECITN..NMKLRHFGSSLSLP
ENSP00000301293  .....SIPGSAVCAFDLTQVAAVFEGR----FRE....QKSPESIWTPVPeDQVPRPRPGCCA--..-APGMQYNASSALP
ENSP00000357266  .....GTRSSAVCAFSLLDIERVFKGK----YKE....LNKETSRWTTYR.GPETNPRPGSCSVG..-----------PSS
ENSP00000359270  .....TLEASAICRYDLAEIQAVFAGP----YME....YQDGSRRWGRYE.GGVPEPRPGSCITD..SLRSQGYNSSQDLP
ENSP00000417570  .....SIAASAVCAFNLSAISQAFNGP----FRY....QENPRAAWLPIA.NPIPNFQCGTLPET..-------GPNENLT
ENSP00000371936  .....SIAASAVCVFNLSAIAQAFSGP----FKY....QENSRSAWLPYP.NPNPHFQCGTVDQG..--------LYVNLT
ENSP00000357908  .....SIPGSAVCAFYLDEIERGFEGK----FKE....QRSLDGAWTPVSeDRVPSPRPGSCAGV..-GGAALFSSSRDLP
ENSP00000251772  .....PPKESALCLFTLRAIKEKIKERIQSCYRG....EGKLSLPWLLNK.EL-------GCINS..---------PLQID
ENSP00000323194  .....SLDESALCIFILKQINDRIKERLQSCYRG....EGTLDLAWLKVKdIP--------CSSA..---------LLTID
ENSP00000356000  .....PPDDSALCAFPIRAINLQIKERLQSCYQG....EGNLELNWLLGK.DV-------QCTKA..-----------PVP
ENSP00000358696  .....PPRQTILCLFTLSNINAHIRRRIQSCYRG....EGTLALPWLLN-.KELPCINTPMQING..----NFCGLVLNQP
ENSP00000352288  .....GGPGAGLCLFPLDKVHAKMEANRNACYTGt...REARDIFYKPFH.GD---IQCGGHAPG..--------SSKSFP
ENSP00000296440  saaagASGASALCAFPLDEVDRLANRTRDACYTRegraEDGTEVAYIEYD.VN------------..-------SDCAQLP
ENSP00000296474  .....VGPNSVVCAFPIDLLDTLIDEGVERCCESpvhpGLRRGLDFFQSP.SFCPNP-PGLEAL-..----SPNTSCRH--
ENSP00000261918  .....---YSAVCVYSLGDIDKVFRTSSLKGY--....-----------H.SSLPNPRPGKCLPD..---------QQPIP
ENSP00000317128  .....RAAPAALCAFRFADVRAAIRAARTACFVE....PAPDVVAVLDSV.----------VQGT..GPACERKLNIQLQP
ENSP00000445569  .....-GTQAALCAFPMVELGASMEQARRLCYTA....-----------G.GRGPSGAEEATVEY..GVTSRCVTLPLDSP
ENSP00000258526  .....SPTTTALCLFRMSEIQARAKRV----SWD....FKTAES------.-H--------CKEG..-----------D--


                          370       380       390         400       410       420       430         
                            |         |         |           |         |         |         |         
d1olza2            DKTL....QFVKDHPLMDDSVTPIDNRPRLIKKD..VNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHA.....
ENSP00000265362  DDVI....TFARSHPAMYNPVFPMNNRPIVIKTDvnYQFTQIVVDRVDAEDGQ-YDVMFIGTDVGTVLKVVSIPKEtwydl
ENSP00000284136  DDVI....SFIKRHSVMYKSVYPVAGGPTFKRINvdYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVSISKEkwnme
ENSP00000466308  DDVI....QFARNHPLMYNSVLPTGGRPLFLQVGanYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGsrpsa
ENSP00000411193  DDVV....TFIRNHPLMYNSIYPIHKRPLIVRIGtdYKYTKIAVDRVNAADGR-YHVLFLGTDRGTVQKVVVLPTNnsvsg
ENSP00000303212  DDAI....RFARSHPLMYQAIKPAHKKPILVKTDgkYNLKQIAVDRVEAEDGQ-YDVLFIGTDNGIVLKVITIYNQemesm
ENSP00000398399  DEVI....NFMRSHPLMYQAVYPLQRRPLVVRTGapYRLTTIAVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDdqele
ENSP00000388768  DKTL....QFVKDHPLMDDSVTPIDNRPRLIKKD..VNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHA.....
ENSP00000306844  DNIL....NFVKKHPLMEEQVGPRWSRPLLVKKG..TNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPW.....
ENSP00000332204  DRVL....NFLKDHFLMDGQV---RSRMLLLQPQ..ARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPR.....
ENSP00000231721  DEVL....QFARAHPLMFWPVRPRHGRPVLVKTHlaQQLHQIVVDRVEAEDGT-YDVIFLGTDSGSVLKVIALQAGgsaep
ENSP00000398776  DE--....-------YRTEFTTALQRVDLFMGQFseVLLTSISTFIKGD-----LTIANLGTSEGRFMQVVVSRSGp....
ENSP00000374083  DETL....SFIKSHPLMDSAVPPIADEPWFTKTRvrYRLTAISVDHSAGPYQN-YTVIFVGSEAGMVLKVLAKTSPfslnd
ENSP00000282394  DDTL....NFIKTHPLMDEAVPSIFNRPWFLRTMvrYRLTKIAVDTAAGPYQN-HTVVFLGSEKGIILKFLARIGNsgfln
ENSP00000342675  DRVL....TFIRDHPLMDRPVFPADGHPLLVTTD..TAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQ.....
ENSP00000301293  DDIL....NFVKTHPLMDEAVPSLGHAPWILRTLmrHQLTRVAVDVGAGPWGN-QTVVFLGSEAGTVLKFLVRPNAstsgt
ENSP00000357266  DKAL....TFMKDHFLMDEQV---VGTPLLVKSG..VEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSs....
ENSP00000359270  SLVL....DFVKLHPLMARPVVPTRGRPLLLKRN..IRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSG.....
ENSP00000417570  ERSL....QDAQRLFLMSEAVQPVTPEPCVTQDS..VRFSHLVVDLVQAKDTL-YHVLYIGTESGTILKALSTASRslh..
ENSP00000371936  ERNL....QDAQKFILMHEVVQPVTTVPSFMEDN..SRFSHVAVDVVQGREAL-VHIIYLATDYGTIKKVRVPLNQtss..
ENSP00000357908  DDVL....TFIKAHPLLDPAVPPVTHQPLLTLTSr.ALLTQVAVDGMAGPHSN-ITVMFLGSNDGTVLKVLTPGGRsggpe
ENSP00000251772  DDF-....-CGQDFNQPLGGTVTIEGTPLFVDKD..DGLTAVAAYDYRG-----RTVVFAGTRSGRIRKILVDLSNpggrp
ENSP00000323194  DNFC....GL--DMNAPLGVSDMVRGIPVFTEDR..DRMTSVIAYVYKN-----HSLAFVGTKSGKLKKIRVDGPRgn...
ENSP00000356000  IDDN....FCGLDINQPLGGSTPVEGLTLYTTSR..DRMTSVASYVYNG-----YSVVFVGTKSGKLKKIRADGPPhg...
ENSP00000358696  LGGL....HVIEGLPLLADSTDGMASVAAYTYR-..------------Q-----HSVVFIGTRSGSLKKVRVDGFQd....
ENSP00000352288  ----....CGSEHLPYPLGSRDGLRGTAVLQRGG..LNLTAVTVAAENN-----HTVAFLGTSDGRILKVYLTPDGt....
ENSP00000296440  VDTLdaypCGSDHTPSPMASRVPLEATPILEWPG..IQLTAVAVTMEDG-----HTIAFLGDSQGQLHRVYLGPGSd....
ENSP00000296474  ----....-----FPLLVSSSFSRVDLFNGLLGP..VQVTALYVTRLDN-----VTVAHMGTMDGRILQVELVRSLny...
ENSP00000261918  TETF....QVADRHPEVAQRVEPMGPLKTPLFHSk.YHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQehsf.
ENSP00000317128  EQLD....CGAAHLQHPLSILQPLKATPVFRAPG..--LTSVAVASVNN-----YTAVFLGTVNGRLLKINLNESM.....
ENSP00000445569  ESYP....CGDEHTPSPIAGRQPLEVQPLLKLGQ..-PVSAVAALQADG-----HMIAFLGDTQGQLYKVFLHGSQ.....
ENSP00000258526  ----....--------QPERVQPIASSTLIHSD-..--LTSVYGTVVMN-----RTVLFLGTGDGQLLKVILGENLt....


                         440                  450        460       470               
                           |                    |          |         |               
d1olza2            ...VHIIEETQLFQD...........FEPVQT.LLLSSKKGNRFVYAGSNSGVVQAPL-a......
ENSP00000265362  ..eEVLLEEMTVFRE...........PTAISA.MELSTK--QQQLYIGSTAGVAQLPLHrcdiy..
ENSP00000284136  ...EVVLEELQIFKH...........SSIILN.MELSLK--QQQLYIGSRDGLVQLSLHrcdty..
ENSP00000466308  ..eGLLLEELHVFED...........SAAVTS.MQISSK--RHQLYVASRSAVAQIALHrcaa...
ENSP00000411193  ...ELILEELEVFKN...........HAPITT.MKISSK--KQQLYVSSNEGVSQVSLHrchiy..
ENSP00000303212  ..eEVILEELQIFKD...........PVPIIS.MEISSK--RQQLYIGSASAVAQVRFHhcdmy..
ENSP00000398399  ...ELMLEEVEVFKD...........PAPVKT.MTISSK--RQQLYVASAVGVTHLSLHrcqay..
ENSP00000388768  ...VHIIEETQLFQD...........FEPVQT.LLLSSKKGNRFVYAGSNSGVVQAPL-.......
ENSP00000306844  ...VHLIEELQLF-D...........QEPMRS.LVLSQS--KKLLFAGSRSQLVQLPVA.......
ENSP00000332204  ...VHIIEELQIFSS...........GQPVQN.LLLDTH--RGLLYAASHSGVVQVPM-.......
ENSP00000231721  ..eEVVLEELQVFKV...........PTPITE.MEISVK--RQMLYVGSRLGVAQLRLHqcety..
ENSP00000398776  ...STPHVNFLLDSHpvs........PEVIVE.HTLNQ---NGYTLVITGKKITKIPL-.......
ENSP00000374083  ...SVLLEEIEAYNHakcsaenee..DKKVIS.LQLDKD--HHALYVAFSSCIIRIPL-srcery.
ENSP00000282394  ..dSLFLEEMSVYNSekcsydgve..DKRIMG.MQLDRA--SSSLYVAFSTCVIKVPL-grcery.
ENSP00000342675  ...LSVLEDLALFPE...........PQPVEN.MKLY----HSWLLVGSRTEVTQV---n......
ENSP00000301293  sglSVFLEEFETYRPdrcgrpgggetGQRLLS.LELDAA--SGGLLAAFPRCVVRVPVArcqqy..
ENSP00000357266  ...AHLVEEIQLFPD...........PEPVRN.LQLAPT--QGAVFVGFSGGVWRVP--rancsvy
ENSP00000359270  ...MHIIEETQVFRE...........SQSVEN.LVISLL--QHSLYVGAPSGVIQLPL-.......
ENSP00000417570  ...GCYLEELHVLPPgr.........REPLRS.LRILHS--ARALFVGLRDGVLRVPLErcaay..
ENSP00000371936  ...SCLLEEIELFPErr.........REPIRS.LQILHS--QSVLFVGLREHVVKIPL-krcqfy.
ENSP00000357908  ...PILLEEIDAYSParcsgkrtaqtARRIIG.LELDTE--GHRLFVAFSGCIVYLPL-srcarh.
ENSP00000251772  ...ALAYESVVAQEG...........SPILRD.LVLSPN--HQYLYAMTEKQVTRVPV-.......
ENSP00000323194  ...ALQYETVQVVDP...........GPVLRD.MAFSKD--HEQLYIMSERQLTRVPV-.......
ENSP00000356000  ...GVQYEMVSVLKD...........GSPILRdMAFSID--QRYLYVMSERQVTRVPV-.......
ENSP00000358696  ...AHLYETVPVVDG...........SPILRD.LLFSPD--HRHIYLLSEKQVSQLPV-.......
ENSP00000352288  ...SSEYDSILVEIN...........KRVKRD.LVLSGD--LGSLYAMTQDKVFRLPV-.......
ENSP00000296440  ...GHPYSTQSIQQG...........SAVSRD.LTFDGT--FEHLYVMTQSTLLKVPV-.......
ENSP00000296474  ...LLYVSNFSLGDS...........GQPVQR.DVSRL---GDHLLFASGDQVFQVPI-.......
ENSP00000261918  ...AFNIMEIQPFRR...........AAAIQT.MSLDAE--RRKLYVSSQWEVSQVPL-dlcevy.
ENSP00000317128  ...QVVSRRVVTVAY...........GEPVHH.VMQFDPADSGYLYLMTSHQMARVKV-.......
ENSP00000445569  ...GQVYHSQQVGPPg..........SAISPD.LLLDSS--GSHLYVLTAHQVDRIPV-.......
ENSP00000258526  ...SNCPEVIYEIKE...........ETPVFY.KLVPDPVKNIYIYLTAGKEV------rrirv..


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Refine alignments

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Include all superfamily members: , or just those assigned by the selected model:
Initial T99 seed sequence: NoYes

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Model: 0048597 (list models)
Initial SAMT99 seed:
Alignment:



Display Options:
Output in FASTA-like format: NoYes
Output column indices: NoYes
Sequence index (number) on each line: NoYes

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Add alignments from genomes

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Select to display   Genome
NoYes   Danio rerio 58 (pseudogenes) - Zebrafish
NoYes   Gallus gallus 58 (pseudogene) - Chicken
NoYes   Homo sapiens 58 (pseudogenes) - Human
NoYes   Homo sapiens 76_38 - Human
NoYes   Pan troglodytes 76_2.1.4 - Chimpanzee
NoYes   Gorilla gorilla 76_3.1 - Western gorilla
NoYes   Pongo abelii 76_2 - Sumatran orangutan
NoYes   Tarsius syrichta 76_1
NoYes   Nomascus leucogenys 76_1.0 - Northern white-cheeked gibbon
NoYes   Papio anubis 76 - Olive baboon
NoYes   Macaca mulatta 76_1 - Rhesus monkey
NoYes   Callithrix jacchus 76_3.2.1 - White-tufted-ear marmoset
NoYes   Otolemur garnettii 76_3 - Small-eared galago
NoYes   Microcebus murinus 76_1 - Gray mouse lemur
NoYes   Rattus norvegicus 76_5.0 - Norway rat
NoYes   Mus musculus 76_38 - House mouse
NoYes   Dipodomys ordii 76_1 - Ord's kangaroo rat
NoYes   Ictidomys tridecemlineatus 76_2 - Thirteen-lined ground squirrel
NoYes   Heterocephalus glaber v1.7-2 - Naked mole-rat
NoYes   Cavia porcellus 76_3 - Domestic guinea pig
NoYes   Oryctolagus cuniculus 76_2 - Rabbit
NoYes   Ochotona princeps 76 - American pika
NoYes   Tupaia belangeri 76 - Northern tree shrew
NoYes   Sus scrofa 76_10.2 - Pig
NoYes   Bos taurus 76_3.1 - Cattle
NoYes   Ovis aries 76_3.1 - Sheep
NoYes   Vicugna pacos 76_1 - Alpaca
NoYes   Tursiops truncatus 76_1 - Bottlenose dolphin
NoYes   Mustela putorius furo 76_1.0 - Domestic ferret
NoYes   Ailuropoda melanoleuca 76_1 - Giant panda
NoYes   Canis familiaris 76_3.1 - Dog
NoYes   Felis catus 76_6.2 - Domestic cat
NoYes   Equus caballus 76_2 - Horse
NoYes   Myotis lucifugus 76_2.0 - Little brown bat
NoYes   Pteropus vampyrus 76_1 - Large flying fox
NoYes   Sorex araneus 76_1 - European shrew
NoYes   Erinaceus europaeus 76 - Western European hedgehog
NoYes   Procavia capensis 76_1 - Cape rock hyrax
NoYes   Loxodonta africana 76_3 - African savanna elephant
NoYes   Echinops telfairi 76 - Small Madagascar hedgehog
NoYes   Dasypus novemcinctus 76_2 - Nine-banded armadillo
NoYes   Choloepus hoffmanni 76_1 - Hoffmann's two-fingered sloth
NoYes   Macropus eugenii 76_1.0 - Tammar wallaby
NoYes   Sarcophilus harrisii 76_7.0 - Tasmanian devil
NoYes   Monodelphis domestica 76_5 - Gray short-tailed opossum
NoYes   Ornithorhynchus anatinus 76_5 - Platypus
NoYes   Saccoglossus kowalevskii v3.0
NoYes   Petromyzon marinus 76_7.0 - Sea lamprey
NoYes   Meleagris gallopavo 76_2 - Turkey
NoYes   Gallus gallus 76_4 - Chicken
NoYes   Anas platyrhynchos 76_1.0 - Mallard
NoYes   Taeniopygia guttata 76_3.2.4 - Zebra finch
NoYes   Ficedula albicollis 76_1.0 - Collared flycatcher
NoYes   Pelodiscus sinensis 76_1.0 - Chinese soft-shelled turtle
NoYes   Anolis carolinensis 76_2.0 - Green anole
NoYes   Xenopus laevis - African clawed frog
NoYes   Xenopus tropicalis 76_4.2 - Tropical clawed frog
NoYes   Latimeria chalumnae 76_1 - Coelacanth
NoYes   Lepisosteus oculatus 76 - Spotted gar
NoYes   Gadus morhua 76_1 - Atlantic cod
NoYes   Tetraodon nigroviridis 76_8 - Spotted green pufferfish
NoYes   Takifugu rubripes 76_4 - Torafugu
NoYes   Gasterosteus aculeatus 76_1 - Three-spined stickleback
NoYes   Oryzias latipes 76_1 - Japanese medaka
NoYes   Xiphophorus maculatus 76_4.4.2 - Southern platyfish
NoYes   Poecilia formosa 76 - Amazon molly
NoYes   Oreochromis niloticus 76_1.0 - Nile tilapia
NoYes   Astyanax mexicanus 76 - Mexican tetra
NoYes   Danio rerio 76_9 - Zebrafish
NoYes   Oikopleura dioica
NoYes   Ciona savignyi 76_2.0 - Pacific transparent sea squirt
NoYes   Ciona intestinalis 76 - Vase tunicate
NoYes   Strongylocentrotus purpuratus v3.1 - Purple sea urchin
NoYes   Adineta vaga
NoYes   Octopus bimaculoides 280
NoYes   Crassostrea gigas 22 - Pacific oyster
NoYes   Lottia gigantea - Owl limpet
NoYes   Helobdella robusta
NoYes   Capitella sp. I
NoYes   Danaus plexippus OGS1.0 - Monarch butterfly
NoYes   Heliconius melpomene - Postman butterfly
NoYes   Bombyx mori - Domestic silkworm
NoYes   Nasonia vitripennis - Jewel wasp
NoYes   Apis mellifera 38.2d - Honey bee
NoYes   Harpegnathos saltator v3.3 - Jerdon's jumping ant
NoYes   Linepithema humile v1.1 - Argentine ant
NoYes   Pogonomyrmex barbatus v1.2 - Red harvester ant
NoYes   Solenopsis invicta v.2.2.3 - Red fire ant
NoYes   Acromyrmex echinatior v3.8 - Panamanian leafcutter ant
NoYes   Atta cephalotes v1.1
NoYes   Camponotus floridanus v3.3 - Florida carpenter ant
NoYes   Lucilia cuprina - Australian sheep blowfly
NoYes   Drosophila grimshawi 1.3
NoYes   Drosophila willistoni 1.3
NoYes   Drosophila pseudoobscura 2.13
NoYes   Drosophila persimilis 1.3
NoYes   Drosophila suzukii
NoYes   Drosophila yakuba 1.3
NoYes   Drosophila simulans 1.3
NoYes   Drosophila sechellia 1.3
NoYes   Drosophila melanogaster 76_5 - Fruit fly
NoYes   Drosophila erecta 1.3
NoYes   Drosophila ananassae 1.3
NoYes   Drosophila virilis 1.2
NoYes   Drosophila mojavensis 1.3
NoYes   Megaselia scalaris 22
NoYes   Aedes aegypti 55 - Yellow fever mosquito
NoYes   Culex pipiens quinquefasciatus - Southern house mosquito
NoYes   Anopheles darlingi 22 - American malaria mosquito
NoYes   Anopheles gambiae 49_3j - African malaria mosquito
NoYes   Tribolium castaneum 3.0 - Red flour beetle
NoYes   Pediculus humanus corporis - Human body louse
NoYes   Acyrthosiphon pisum - Pea aphid
NoYes   Rhodnius prolixus 22
NoYes   Daphnia pulex - Common water flea
NoYes   Strigamia maritima 22
NoYes   Sarcoptes scabiei
NoYes   Tetranychus urticae - Two-spotted spider mite
NoYes   Ixodes scapularis - Black-legged tick
NoYes   Pristionchus pacificus
NoYes   Meloidogyne incognita - Southern root-knot nematode
NoYes   Meloidogyne hapla
NoYes   Onchocerca volvulus 22
NoYes   Brugia malayi WS250 - Agent of lymphatic filariasis
NoYes   Caenorhabditis japonica
NoYes   Caenorhabditis brenneri
NoYes   Caenorhabditis remanei
NoYes   Caenorhabditis elegans 76_235 - Roundworm
NoYes   Caenorhabditis briggsae 2
NoYes   Trichinella spiralis 22
NoYes   Hymenolepis microstoma
NoYes   Echinococcus multilocularis
NoYes   Echinococcus granulosus
NoYes   Taenia solium - Pork tapeworm
NoYes   Schistosoma mansoni
NoYes   Mnemiopsis leidyi - Sea walnut
NoYes   Acropora digitifera v1.0
NoYes   Nematostella vectensis 1.0 - Starlet sea anemone
NoYes   Hydra vulgaris
NoYes   Amphimedon queenslandica
NoYes   Trichoplax adhaerens
NoYes   Proterospongia sp. ATCC 50818
NoYes   Monosiga brevicollis
NoYes   Xenopus (Silurana) tropicalis v7.1 (annotation v7.2) - Tropical clawed frog
NoYes   Drosophila melanogaster FlyBase 5.12 - Fruit fly
NoYes   Anopheles gambiae VectorBase AgamP3.6 - African malaria mosquito
NoYes   Ascaris suum Victoria/Ghent - Pig roundworm
NoYes   Caenorhabditis elegans WormBase WS218 - Roundworm
NoYes   Homo sapiens 69_37 - Human
NoYes   Pan troglodytes 69_2.1.4 - Chimpanzee
NoYes   Gorilla gorilla 69_3.1 - Western gorilla
NoYes   Pongo abelii 69_2 - Sumatran orangutan
NoYes   Nomascus leucogenys 69_1.0 - Northern white-cheeked gibbon
NoYes   Macaca mulatta 69_1 - Rhesus monkey
NoYes   Callithrix jacchus 69_3.2.1 - White-tufted-ear marmoset
NoYes   Otolemur garnettii 69_3 - Small-eared galago
NoYes   Tarsius syrichta 69_1
NoYes   Microcebus murinus 69_1 - Gray mouse lemur
NoYes   Rattus norvegicus 69_3.4 - Norway rat
NoYes   Mus musculus 69_38 - House mouse
NoYes   Dipodomys ordii 69_1 - Ord's kangaroo rat
NoYes   Ictidomys tridecemlineatus 69_2 - Thirteen-lined ground squirrel
NoYes   Cavia porcellus 69_3 - Domestic guinea pig
NoYes   Oryctolagus cuniculus 69_2 - Rabbit
NoYes   Ochotona princeps 69 - American pika
NoYes   Tupaia belangeri 69 - Northern tree shrew
NoYes   Sus scrofa 69_10.2 - Pig
NoYes   Bos taurus 69_3.1 - Cattle
NoYes   Vicugna pacos 69_1 - Alpaca
NoYes   Tursiops truncatus 69_1 - Bottlenose dolphin
NoYes   Mustela putorius furo 69_1.0 - Domestic ferret
NoYes   Ailuropoda melanoleuca 69_1 - Giant panda
NoYes   Canis familiaris 69_3.1 - Dog
NoYes   Felis catus 69 - Domestic cat
NoYes   Equus caballus 69_2 - Horse
NoYes   Myotis lucifugus 69_2.0 - Little brown bat
NoYes   Pteropus vampyrus 69_1 - Large flying fox
NoYes   Sorex araneus 69_1 - European shrew
NoYes   Erinaceus europaeus 69 - Western European hedgehog
NoYes   Procavia capensis 69_1 - Cape rock hyrax
NoYes   Loxodonta africana 69_3 - African savanna elephant
NoYes   Echinops telfairi 69 - Small Madagascar hedgehog
NoYes   Dasypus novemcinctus 69_2 - Nine-banded armadillo
NoYes   Choloepus hoffmanni 69_1 - Hoffmann's two-fingered sloth
NoYes   Macropus eugenii 69_1.0 - Tammar wallaby
NoYes   Sarcophilus harrisii 69_7.0 - Tasmanian devil
NoYes   Monodelphis domestica 69_5 - Gray short-tailed opossum
NoYes   Ornithorhynchus anatinus 69_5 - Platypus
NoYes   Petromyzon marinus 69_7.0 - Sea lamprey
NoYes   Meleagris gallopavo 69_2 - Turkey
NoYes   Gallus gallus 69_2 - Chicken
NoYes   Taeniopygia guttata 69_3.2.4 - Zebra finch
NoYes   Pelodiscus sinensis 69_1.0 - Chinese soft-shelled turtle
NoYes   Anolis carolinensis 69_2.0 - Green anole
NoYes   Xenopus tropicalis 69_4.2 - Tropical clawed frog
NoYes   Latimeria chalumnae 69_1 - Coelacanth
NoYes   Gadus morhua 69_1 - Atlantic cod
NoYes   Tetraodon nigroviridis 69_8 - Spotted green pufferfish
NoYes   Takifugu rubripes 69_4 - Torafugu
NoYes   Gasterosteus aculeatus 69_1 - Three-spined stickleback
NoYes   Oryzias latipes 69_1 - Japanese medaka
NoYes   Xiphophorus maculatus 69_4.4.2 - Southern platyfish
NoYes   Oreochromis niloticus 69_1.0 - Nile tilapia
NoYes   Danio rerio 69_9 - Zebrafish
NoYes   Ciona savignyi 69_2.0 - Pacific transparent sea squirt
NoYes   Ciona intestinalis 69 - Vase tunicate
NoYes   Drosophila melanogaster 69_5 - Fruit fly
NoYes   Caenorhabditis elegans 69_215 - Roundworm
NoYes   Homo sapiens 75_37 - Human
NoYes   Homo sapiens - Human
NoYes   Mus musculus 63_37 (longest transcript per gene) - House mouse
NoYes   Heliconius numata
NoYes   Loa loa v3.3 - Eye worm
NoYes   Wuchereria bancrofti v1.0 - Agent of lymphatic filariasis
NoYes   Brugia malayi v1.0 - Agent of lymphatic filariasis
NoYes   Nicotiana benthamiana 0.4.4
NoYes   NCBI 2017_08 genome
NoYes   STRING v9.0.5 (STRING)
NoYes   Uniprot 2018_03 genome
NoYes   NCBI viral sequences (Viral)
NoYes   PDB chains (SCOP 1.75) (PDB)
NoYes   Protein Data Bank (all PDB sequenc)
NoYes   SCOP2 SCOPe CATH ECOD (all domain sequ)
NoYes   TargetDB (Targets)
NoYes   UniProt viral sequences (Viral)
NoYes   ALL (only advised for small superfamilies)


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