SUPERFAMILY 1.75 HMM library and genome assignments server

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Sema domain alignments in Xenopus tropicalis 76_4.2

These alignments are sequences aligned to the 0048597 model.

Sophisticated options are available for refining alignments:


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Alignments

The numbers along the top are the segment numbers of the HMM states, and each sequence is seperately aligned to the model.
The first sequence is the seed the model was built from.
Upper case letters are aligned, lower case letters are insertions, '-' signifies a deletion and '.' is nothing.

                                                                                                    
                                                                                                    
d1olza2               ....................................................................fa--PIPRIT
ENSXETP00000031145  ....................................................................sv------LE
ENSXETP00000015932  ..................................................................gtah--------
ENSXETP00000015948  ...........................................................rlklsyqdlms--------
ENSXETP00000011952  .............................................................niprlklsy------KD
ENSXETP00000059604  ................................................................whtplt-------D
ENSXETP00000017224  ...................................................................ifv---VFFTE
ENSXETP00000015621  ...................................................................ppr-VYLSYRD
ENSXETP00000049036  ...................................................................ppr-VYLSYRD
ENSXETP00000059989  ....................................................................pr------IT
ENSXETP00000023736  ....................................................................pr------IT
ENSXETP00000060752  ....................................................................ts--------
ENSXETP00000002701  ....................................................................vv--------
ENSXETP00000028414  ....................................................................rs--------
ENSXETP00000040545  ....................................................................im--------
ENSXETP00000033273  ................................................................ritvty--------
ENSXETP00000039840  ...................................................................gnd--------
ENSXETP00000039837  ...................................................................gnd--------
ENSXETP00000012836  .....................................................tssypwfrglasdddta--------
ENSXETP00000047775  ...............................................................niqkilm--------
ENSXETP00000047038  ....................................................hnlqsfttdtpiqniimf--------
ENSXETP00000040369  ....................................................................rt--------
ENSXETP00000039399  ...............................................................lhfplpd--------
ENSXETP00000025005  ...................................................................aqh--------
ENSXETP00000015919  .....................................................yqfpnftasrpiqnlvs--------
ENSXETP00000007320  ..................................................................tfav--------
ENSXETP00000038644  ....................................................................fv--------
ENSXETP00000048152  .....................................................................f--------
ENSXETP00000017222  ......................................................................--------
ENSXETP00000016825  ...................................................................vps--------
ENSXETP00000059362  ......................................................................--------
ENSXETP00000061727  ......................................................................--------
ENSXETP00000059887  .....................................................................k--------
ENSXETP00000040366  .....................................................................e--------
ENSXETP00000003087  ................................................eeqldcgaahlqhplaitrplp--------
ENSXETP00000003091  ................................................eeqldcgaahlqhplaitrplp--------
ENSXETP00000051361  qfvnafswerifffpyfvpeldnakilsvknpkgadlqlwglahlpcgsdirrgvilssfhfmksgghfw--------
ENSXETP00000038482  ....................................................................pl--------


                      10         20        30        40        50            60        70           
                       |          |         |         |         |             |         |           
d1olza2               WEHREVHLVQF.HEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEK....QHEVYWKVSEDKKAKCAEK....
ENSXETP00000031145  MLESNNLITFN.GWPNSSSYHTFVLDEERGRLYVGAKDHIFSFNLANV-KE....FQKILWPVTNIRRDECKWA....
ENSXETP00000015932  --------FLS.FLLNTTDYRILLKDEDHDRMYVGSKDFILSLDLQDINRE....PLIIHWPASQQRIEECVLS....
ENSXETP00000015948  ----LHGLRTF.TLERSCCYDALFLDEERGRLFVGGKNYLMSLSLDNISKQ....ELAIHWPAPVEWREECNWA....
ENSXETP00000011952  LLLSNSCVPFLhPLTEGLEFQTLLLDEERGKLLLGAKDHIYLLDLVDLNKN....LRKIHWPAAKEKIEFCKRA....
ENSXETP00000059604  LKASGTAHFLS.FLLNTTDYRILLKDEDHDRMYVGSKDFILSLDLQDINRE....PLIIHWPASQQRIEECVLS....
ENSXETP00000017224  LQETKTSEFYS.ISQSPLDYRILLMDEDQDRIYVGSKDHILSLNINNISHD....PLSVFWPASTSKVEECKMA....
ENSXETP00000015621  LMESRSARSFT.FGFNTSDYRILLLDQDQDRMYVGSRDYVLSLDLGNINRE....PLIIHWPAPLNRHKECLMA....
ENSXETP00000049036  LMESRSARSFT.FGFNTSDYRILLLDQDQDRMYVGSRDYVLSLDLGNINRE....PLIIHWPAPLNRHKECLMA....
ENSXETP00000059989  WHLKETNLMHF.HVSGISNYSTLLLSEEKDVLYVGAREAIFAVSSLNVAEK....LHEAYWKVSDEKNNECAWK....
ENSXETP00000023736  WHLKETNLMHF.HVSGISNYSTLLLSEEKDVLYVGAREAIFAVSSLNVAEK....LHEAYWKVSDEKNNECAWK....
ENSXETP00000060752  ----------V.FHSPFLDLNIMYLDEYQERLFVGGRNLLYSLSLEQVSEN....YKEIHWPSTDQQVEDCSRK....
ENSXETP00000002701  --------RQS.WRNGVSQVMTLTLDEDRGALYVGAREVIFSLDLSNIGKEl...RPPIIWQAPADKKAECAQK....
ENSXETP00000028414  -------FKTF.EADGVTYFTTLLLGKDGSALYVGAQEALFSLNSTDFTSAdy..HSKIAWQADEEKKKECAFK....
ENSXETP00000040545  -----------.----------------NRTLYIAARDHIYTVDLETSYTEeiffSKKLTWKSKQSDVDTCRMK....
ENSXETP00000033273  ---NEILDLRR.FSSRVSNYSTLLLEDERGILYVGARGAIFSLNSTNISQRy...QKAIPWEVTAQKHDECIKK....
ENSXETP00000039840  -----------.---SQHSLDFQLMLKIRDTLYVAGRDQVYAINLNEVPKTevtpSRRLTWRSGQADRKNCAMK....
ENSXETP00000039837  -----------.---SQHSLDFQLMLKIRDTLYVAGRDQVYAINLNEVPKTevtpSRRLTWRSGQADRKNCAMK....
ENSXETP00000012836  -----------.----HLGLDFQKMLKLNQTLFVAARDHVYAIDLRRAKEAi...IPDKYVTWKTQDMENCAMR....
ENSXETP00000047775  -----------.---------------VNRTLYVGDRDALYQIMLDSYSTElqy.HKKLIWKSNHQDINVCRMK....
ENSXETP00000047038  -----------.----------------KGYIYVGAVNKIYVLNEN---LT....KVSEYKTGPLLVHSHCLPCk...
ENSXETP00000040369  -----------.FTGTDWSLTHLVVHNKTGEVYLGAINRIYKLSNN---LT....LMRTHVTGPVEDNEKCYPPpsvq
ENSXETP00000039399  -----------.---------------------------------------....----------IGSAAALQN....
ENSXETP00000025005  -----------.---SDWTFNHLVVDVRSGHIYLGAVNRIYKLSED---LK....ILVTHQTGPSEDNPKCYPPsivq
ENSXETP00000015919  -----------.---------------FEDSLFLTTTNHLYVLKGNELHL-....LQNITTGPTDSQCTLCSKC....
ENSXETP00000007320  -----------.---SDTSLTHLAVHKHTGDVYLGAVNRIFKLSEN---LT....ELRSHLTGPIADNSSCYPPpsvr
ENSXETP00000038644  -----------.--QNNTIFNHLTLDANTGTLYVGATNSLYQLTEN---LA....VEMLVRTGPVWDSKECLPPvst.
ENSXETP00000048152  ----------L.SFFSDTDLNHLAVNNDTGIVYIGAVNRLYQLSAE---LD....MQVNFTTGPKLDKKSCTPPidsq
ENSXETP00000017222  -----------.---------------------------------------....-------------------....
ENSXETP00000016825  -----------.FLRPNVTFNHMARDPTSGFIYIGAVNWIFQLSSD---LQ....LLLEDSTGPREDSPECLPFkdlk
ENSXETP00000059362  -----------.-------------------LYVGGTNILYLLDFTTKEIN....KALLLNISMHFTLEDCT--....
ENSXETP00000061727  -----------.---------------------------------------....-------------------....
ENSXETP00000059887  -----------.-------------------LYVGGTNILYLLDFTTKEIN....KVQG---PVYLCFYLCMHTg...
ENSXETP00000040366  -----------.---------------------------------------....-------------------....
ENSXETP00000003087  -----------.---------------------------------------....-------------------....
ENSXETP00000003091  -----------.---------------------------------------....-------------------....
ENSXETP00000051361  -----------.---------------------------------------....-------------------....
ENSXETP00000038482  -----------.---------------------------------------....-------------------....


                        80              90         100       110       120                          
                         |               |           |         |         |                          
d1olza2               .GKSKQ......TECLNYIRVLQPLS..ATSLYVCGTNAFQPACDHLNLTSFKFL.......................
ENSXETP00000031145  .GKDIM......KECANFIKVLKVYN..HTHLYACGTGAFHPVCTYIDVGNYPEDnifkled................
ENSXETP00000015932  .GKDSN......GECGNFIRLIQPWN..RTHLYVCGTGAYNPVCTYINRGRKAQDyvfylep................
ENSXETP00000015948  .GKDIN......IDCMNYVKILQPYN..RTHLFTCGTGAFHPTCGFVHVGQRTDDtvfkmdl................
ENSXETP00000011952  .GKDNN......LECANFIKVLHHYN..KTHAYTCGTGAFHPLCGYVELGTPKEEvvfqldt................
ENSXETP00000059604  .GKDSN......GECGNFIRLIQPWN..RTHLYVCGTGAYNPVCTYINRGRKAQAselshtpggrgsraadsllsptp
ENSXETP00000017224  .GKDPT......HGCGNFVRVIQNFN..RTHLYVCGSGAFSPVCTYINRGRRSEDhifaid.................
ENSXETP00000015621  .GRGRV......DECYNYLRVIQPLN..RTHLYACGTGAYQPQCAVIYRGWRSEDyvfrivp................
ENSXETP00000049036  .GRGRV......DECYNYLRVIQPLN..RTHLYACGTGAYQPQCAVIYRGWRSEDyvfrivp................
ENSXETP00000059989  .GKSKQ......TECLNYIRVIQPLN..DKTLYVCGTNAFQPTCDYLNLTDFRLL.......................
ENSXETP00000023736  .GKSKQ......TECLNYIRVIQPLN..DKTLYVCGTNAFQPTCDYLNLTDFRLL.......................
ENSXETP00000060752  .GRDKS......-ECANFIRVLHHYN..RTHLLACGTGAFDPVCAFIRAGLRSQEhlfqlep................
ENSXETP00000002701  .GKSNQ......TECFNYIRFLEEYN..QTHLITCGTYAFQPKCAYIALSGFTLDa......................
ENSXETP00000028414  .GKDPQ......RDCQNYIKILLQLN..STHLYTCGTFAFSPTCTYIKISDFSLEknalgh.................
ENSXETP00000040545  .GKHKD......-ECHNFIKVLLKRD..EDTLFVCGTNAFNPSCRYYKMDTLEFL.......................
ENSXETP00000033273  .GKNNQ......TECFNHIRLLLRFN..ETHLYVCGTYAFSPLCSFIDSRTFVLS.......................
ENSXETP00000039840  .GKHKD......-ECHNYIKVFVPRN..DEMVFVCGTNAFNPMCRYYRLNTFDYD.......................
ENSXETP00000039837  .GKHKD......-ECHNYIKVFVPRN..DEMVFVCGTNAFNPMCRYYRLNTFDYD.......................
ENSXETP00000012836  .GKLRD......-ECYNYIKVLVPKN..DQTLVACGTNSFNPMCRSYKIKTLEQE.......................
ENSXETP00000047775  .GKQED......-ECRNFVKVLLLKD..YQTLFICGTNAFNPVCADYSIDTLEQV.......................
ENSXETP00000047038  .NCTDNflspngTWKDNVNMALFVEDfyDDQLISCGN-IRRGECQRHTLHSDKPWdiasnvhclys............
ENSXETP00000040369  sCPHGL......VSTNNVNKLLLIDYs.ENRLIACGS-ASQGICQFLRLDDLFKLge.....................
ENSXETP00000039399  .SEHWQ......TECFNFIRILAPVN..GSHLYTCGTYAFNPTCTYIELDHFSMPknpngt.................
ENSXETP00000025005  pCNDQL......VLTNNINKMLLIDYk.ENRLIACGS-LYQGICKLLRLDDLFKLge.....................
ENSXETP00000015919  .QLGEAlpk...QPEDTVSQVLAVDPe.ESVIYSCGS-SLHGLCYMHIIASSKIVeseclfrqs..............
ENSXETP00000007320  vCTHKL......SPTDNVNRLLLIDYt.GKRVVACGS-VWQGICQFLRLDDLFKLge.....................
ENSXETP00000038644  .DCPQA......QNTNNHNKLLLVVPs.KRELIVCGS-VYQGICESRRLGSVQTVlfrp...................
ENSXETP00000048152  .QCPSA......EITDNYNKLLLLDKp.HERIIVCGS-IFKGICSLRAMSDISTElwyk...................
ENSXETP00000017222  .-----......--------------..---------------------------.......................
ENSXETP00000016825  .DCRQA......TLTPNTNKLLAVNTh.GGELITCGQ-VFQGICEKRRLSNISDIifqt...................
ENSXETP00000059362  .-----......-DCMIYVTLAGQLN..RS-LIICGTSGTRTACWKLVVNEENKI.......................
ENSXETP00000061727  .-----......--------------..---------------------------.......................
ENSXETP00000059887  .ACLDC......TDCMIYVTLAGQLN..RS-LIICGTSGTRTACWKLVENNNLVLiigeh..................
ENSXETP00000040366  .-----......--------------..---------------------------.......................
ENSXETP00000003087  .-----......--------------..---------------------------.......................
ENSXETP00000003091  .-----......--------------..---------------------------.......................
ENSXETP00000051361  .-----......--------------..---------------------------.......................
ENSXETP00000038482  .-----......--------------..---------------------------.......................


                                      130          140                  150             160       17
                                        |            |                    |               |         
d1olza2               ............GKNEDGKGRCP...FDPAHSYTSVMV.....DG......ELYSGTSY......NFLGSEPIISRNS
ENSXETP00000031145  ............SFFENGRGKSP...YDPKLLTASILI.....DG......ELYSGTAA......DFMGRDFAIFRTL
ENSXETP00000015932  ............DRVESGKGKCA...YDPKLDSVSALI.....NE......ELYSGVYI......DFMGTDAAIFRAM
ENSXETP00000015948  ............RRMEDGKGRCP...YDPKHIAAAVLV.....GD......ELYSGVAT......DLMGRDFTIFRSL
ENSXETP00000011952  ............QNLESGRLKCP...FDPQPPFASIMT.....DE......YLFAGTAS......DFLGKETTFTRSM
ENSXETP00000059604  adhkdyvfylepDRVESGKGKCA...YDPKLDSVSALI.....NE......ELYSGVYI......DFMGTDAAIFRAM
ENSXETP00000017224  ............YKNESGKGRCS...FNPKVNTVSVMI.....NE......ELFSGMYI......DFMGTDSAIFRSL
ENSXETP00000015621  ............ASLESGKGRCP...YDPKQENMATLI.....DG......VLYAGVQV......DYMGTDSAIFRTM
ENSXETP00000049036  ............ASLESGKGRCP...YDPKQENMATLI.....DG......VLYAGVQV......DYMGTDSAIFRTM
ENSXETP00000059989  ............GRNEDGKGRCP...FDPAQSYISVMV.....DG......ELYSGTSF......NFLGSEPIIFRHS
ENSXETP00000023736  ............GRNEDGKGRCP...FDPAQSYISVMV.....DG......ELYSGTSF......NFLGSEPIIFRHS
ENSXETP00000060752  ............QKFERGRGRCP...FDPNSSVISTLT.....DQgg....ELFVGLYN......DFWGRDATIFRTT
ENSXETP00000002701  ............DNLEEGKGKVP...YDPAKGYTGLIL.....DG......ALYSATMN......NFLGTEPVIMRIV
ENSXETP00000028414  ............PILEDGKVRCP...FDPEYNSTAIMV.....DG......EMYAGTVS......NFQGNEPIIYKSH
ENSXETP00000040545  ............DEEISGMARCP...YDAKHANVALFA.....DG......KLYSATVT......DFLAIDAVIYRSL
ENSXETP00000033273  ............SETEEGKEKCP...YDPAKGYVGLLV.....DG......GLYTASLY......EFR-NLPDIRRNL
ENSXETP00000039840  ............GEEISGLARCP...FDARQTNVALFA.....DG......KLYSATMA......DFQASDAVIYRSM
ENSXETP00000039837  ............GEEISGLARCP...FDARQTNVALFA.....DG......KLYSATMA......DFQASDAVIYRSM
ENSXETP00000012836  ............GEEFNGQARCP...FDAKQANVALFA.....DG......NLYSATMA......DFQASDAVIYRSL
ENSXETP00000047775  ............GDTLSGMARCP...YDPKHANVALFA.....DG......MLFTATVT......DFLAIDAVLYRSL
ENSXETP00000047038  ............SQMIEDKDNCPdciVSTTGSKILVTV.....RDrfv...KFFVGSTL......--TGQPSTIHSVS
ENSXETP00000040369  ............PHHRKEHYLSS...VNESGTMSGVIIevpngQN......KLFVGTPId.....GKSEYFPTLSSRK
ENSXETP00000039399  ............IITMDGRGQSP...FDPQHNYTSITI.....DG......ELYTGTMN......NFRGNEPVIFRNL
ENSXETP00000025005  ............PSHKKEHYLSG...VNESGSVFGVIVshnnlDD......KLFIATSVd.....GKPEYFPTISSRK
ENSXETP00000015919  ............GNSASSCPDCI...ASPLGTLLSVVT.....QSrgv...YFYTASSLdsriaeSYSPTSISIRRLL
ENSXETP00000007320  ............PHHRKEHYLSG...AREPDSMAGVIV.....DQdveqs.KLFIGTSId.....GKSEYFPTLSSRR
ENSXETP00000038644  ............ERPVDTQYVAA...NDPNVTTVGLVAlsk..DGsp....LLFVGRGYts....KGAGGIPPITTRN
ENSXETP00000048152  ............DNLGEKSFVAS...NDEVISTVGLVT.....NHgkekrrLLFVGKGH......VQNDNGIIISTRI
ENSXETP00000017222  ............-----------...------------.....--......--------......-------------
ENSXETP00000016825  ............IDPGDNQFVAA...NDPKVTTVGIVE.....GPsenhq.LLFVGRGLta....RLSSGIPPITIRQ
ENSXETP00000059362  ............QQYSLPEEFVP...RMPENNNLVLII.....EN......EVYST---......NNGRRDKYIFKKI
ENSXETP00000061727  ............-----------...------------.....--......--------......-------------
ENSXETP00000059887  ............YILVQILSLVT...ALPSIRTLSFIL.....EN......EVYST---......NNGRRDKYIFKKI
ENSXETP00000040366  ............-----------...------------.....--......--------......-------------
ENSXETP00000003087  ............-----------...------------.....--......--------......-------------
ENSXETP00000003091  ............-----------...------------.....--......--------......-------------
ENSXETP00000051361  ............-----------...------------.....--......--------......-------------
ENSXETP00000038482  ............-----------...------------.....--......--------......-------------


                      0                   180         190                     200       210         
                      |                     |           |                       |         |         
d1olza2               S...HS.........PLRTEYAIPWLN.EPS.FVFADV............IRKS..PDSPDGEDDRVYFFFTEVSVE.
ENSXETP00000031145  Gnh.HP.........IRTEQHDSRWLN.DPR.FIGAYL............VPES..D---NPEDDKVYFFFRENAID.
ENSXETP00000015932  G...KQaa.......MRTDQYNSRWLN.DPA.FVHVHL............IPDS..A---DRNDDKLYFFFREKSTD.
ENSXETP00000015948  Grr.PP.........LRTEQHDSRWLN.EPK.FVKVFW............IPES..E---NPDDDKIYFFFKETPVE.
ENSXETP00000011952  G...PPpdhhf....IKTDTDDHYWLN.GAK.FFGAYA............IPDT..Y---NPDDDKIYFFFRESSPE.
ENSXETP00000059604  G...KQaa.......MRTDQYNSRWLN.DPA.FVHVHL............IPDS..A---DRNDDKLYFFFREKSTD.
ENSXETP00000017224  T...KRna.......VRTDQHNSKWLS.EPI.FVDAQL............LPDG..T---DPNDAKVYFFLKERLTD.
ENSXETP00000015621  Ghk.PP.........IRTEQYDSRWLN.DPL.FVGSLV............VSES..S---FKEDDKLYILFRERSLE.
ENSXETP00000049036  Ghk.PP.........IRTEQYDSRWLN.DPL.FVGSLV............VSES..S---FKEDDKLYILFRERSLE.
ENSXETP00000059989  S...QS.........QLRTEYAVPWLN.EPS.FVYADV............IRAP..ANNPEGDDDKVYFFFTEVSVE.
ENSXETP00000023736  S...QS.........QLRTEYAVPWLN.EPS.FVYADV............IRAP..ANNPEGDDDKVYFFFTEVSVE.
ENSXETP00000060752  Ghl.PP.........IRTEHDDDRILT.EPK.FVGSYM............IPDN..E---DKDDNKMYFFYTEKAIE.
ENSXETP00000002701  Gq..HN.........IMKTEYLASWLN.EPN.FVSSAH............MPES..VGSEIGDDDKIYYFFTERALE.
ENSXETP00000028414  D...SRi........TLKTENSLYWLQ.DPA.FVGSAY............IQESlpKGNPVGDDDKIYYFFSETGKE.
ENSXETP00000040545  Gdg.PT.........LRTVKYDSKWLK.EPY.FVHA--............----..----VDYGDLIYFFYREIAVE.
ENSXETP00000033273  Lq..RS.........LKTEESNLHWLNvDPE.FVSAAL............VQES..MNVEVGDDDKIYYFFNEKVVEe
ENSXETP00000039840  G...DGfa.......LRTIKYDSKWLK.EPH.FLHA--............----..----IEYGNYIYFFFREIAVE.
ENSXETP00000039837  G...DGfa.......LRTIKYDSKWLK.EPH.FLHA--............----..----IEYGNYIYFFFREIAVE.
ENSXETP00000012836  G...EKspv......LRTVKYDSKWLR.EPH.FIHA--............----..----VEYGNYVYFFFREISME.
ENSXETP00000047775  G...PRla.......LRSVKHDSKWFK.DPY.FVHA--............----..----VEWKEHVYFFFREVAME.
ENSXETP00000047038  V...RR.........LKETQDGFEYLT.DQS.YIDVLPqlrdi.......YPIK..YIYTFESNNFVYFLTVQRESI.
ENSXETP00000040369  Lm..GNeenaemfgfVYQ---------.-DE.FVSSQLkipsdtlskfptFDIY..YVYSFSSEQFVYYLTLQLDTQl
ENSXETP00000039399  Gt..KV.........SLRTEGSHGWLN.ADAvFVGSFN............PQG-..----SSPDSKVYFFFDETTRE.
ENSXETP00000025005  L...TK.........DSEADGMFAYVF.HDE.FVASMIkipsdtftiipdFDIY..YIYGFNSGNYVYFLTLQPEMTf
ENSXETP00000015919  G...SQdg.......F------SPGFH.SLS.VLESYRds..........YPIH..YVHTFVSGSYVYFLTVQPEHP.
ENSXETP00000007320  Lv..QD.........EESAEMFRLVYQ.-DE.FVSSQIkvpsdtlslhpsFDIY..YVYGFVSKIFVYFLTLQLDTQq
ENSXETP00000038644  LevgGD.........SEMESHSVFSYE.DTA.KLAVVGrlse........YNHH..FIKAFTHKSNVYFLFYRRDLK.
ENSXETP00000048152  L...EK.........KEDRDVFEVYQD.SAT.FKSVDHik..........HFQQ..FVTAFENDDYVYFVSTRAD--.
ENSXETP00000017222  -...--.........------------.---.------............----..---------------------.
ENSXETP00000016825  L...EK.........---TPVFSNEGL.GKL.VVGDFSd...........YNNT..FVGIFSNNGHVYFLFFRRGSK.
ENSXETP00000059362  Y...GQ.........QPFLYTGDGFMR.KPH.YIKALV............VDSK..----EKYQDKILLFFREDNEN.
ENSXETP00000061727  -...--.........------------.---.------............----..---------------------.
ENSXETP00000059887  Y...GQ.........QPFLYTGDGFMR.KPH.YIKALV............VDSK..----EKYQDKILLFFREDNEN.
ENSXETP00000040366  -...--.........------------.---.------............----..---------------------.
ENSXETP00000003087  -...--.........------------.---.------............----..---------------------.
ENSXETP00000003091  -...--.........------------.---.------............----..---------------------.
ENSXETP00000051361  -...--.........------------.---.------............----..---------------------.
ENSXETP00000038482  -...--.........------------.---.------............----..---------------------.


                        220       230       240         250       260                270         280
                          |         |         |           |         |                  |           |
d1olza2               ...YEFVFRVLIPRIARVCKGDQGG.LRTLQ.KKWTSFLKARLICSRPDS.........GLVFNVLRDVFVLRSP..G
ENSXETP00000031145  ...GEHTGKATHARIGQLCKNDFGG.HRSLV.NKWTTFLKARLICSVPGPngi......DTHFDELQDVFLMNSK..D
ENSXETP00000015932  ...SP-HSPTVYSRIGRVCLNDDGG.HCCLV.NKWSTFLKARLICSVPGAdgi......ETHFDELQDVFIQQTQ..D
ENSXETP00000015948  ...GAGGVKQSYARIGQICRNDLGG.QRSLV.NKWTTFLKARLVCSVPGNeigg.....DTHFDELRDVFLLQTR..D
ENSXETP00000011952  ...GSFSEKSVFSRVGRVCKNDIGG.QRSLI.NKWTTFLKARLVCSIPAQdgg......DTYFDELQDIFLLPTK..D
ENSXETP00000059604  ...SP-HSPTVYSRIGRVCLNDDGG.HCCLV.NKWSTFLKARLICSVPGAdgi......ETHFDELQDVFIQQTQ..D
ENSXETP00000017224  ...NSGSTKQIHSMIARVCPNDIGG.QRSLV.NKWTTFLKARLVCSVMDDdgt......ETYFDELEDVFLMETD..N
ENSXETP00000015621  ...GE-NGPALVSRIARVCLNDEGG.LRSLV.GKWTSYLKARLVCSVIGQdgv......ETSFDQLRDVFIQPTH..D
ENSXETP00000049036  ...GE-NGPALVSRIARVCLNDEGG.LRSLV.GKWTSYLKARLVCSVIGQdgv......ETSFDQLRDVFIQPTH..D
ENSXETP00000059989  ...YEFFSKLLIPRVARVCKGDQGG.LRTLQ.KKWTSFLKAKLICHSSEN.........NLIFNVVSDVFILKHS..D
ENSXETP00000023736  ...YEFFSKLLIPRVARVCKGDQGG.LRTLQ.KKWTSFLKAKLICHSSEN.........NLIFNVVSDVFILKHS..D
ENSXETP00000060752  ...GDKGVQAIYSRVGRVCANDIGG.QRMMV.NKWTTFLKTRLICSVPGPngi......DTFFDELEDVFLLHTR..D
ENSXETP00000002701  ...YDCSSEQVVSRVARICKGDLGG.ARTLQ.RKWTSFLKARLLCSIPEL.........QLNFNLLKSVFKLEAE..E
ENSXETP00000028414  ...FDFFENTIVSRIARVCKGDLGG.ERVLQ.RRWTSFLKAQLICSCPGD.........GFPFNVLKDMFVLTPGeeH
ENSXETP00000040545  ...YNSMGKVVFPRVAQVCKNDMGGsQRVLE.KQWTSFLKARLNCSVPGDs........HFYFNILQAVTDVIHI..N
ENSXETP00000033273  ...NSAFLGSKTASVARVCKDDMGG.KKILQ.KKWTSFLKARLVCYMPF-.........---YEVLKSAYTLELG..S
ENSXETP00000039840  ...HNNLGKAVHSRVARICKNDLGGsQRVLE.KHWTSFVKARLNCSVPGDs........FFYFDVLQSITDIIEI..N
ENSXETP00000039837  ...HNNLGKAVHSRVARICKNDLGGsQRVLE.KHWTSFVKARLNCSVPGDs........FFYFDVLQSITDIIEI..N
ENSXETP00000012836  ...YTTIGKVTFSRVGRVCKNDMGGsPRVLE.KYWTSFLKARLNCSVPGDs........FFYFDVLQSVSDILTI..N
ENSXETP00000047775  ...FNYLEKVVVSRVARVCKNDMGGsQRVLE.KQFSSFLKARLNCSVPGDs........HFYFNVIQTVSNILNI..G
ENSXETP00000047038  ...D---SQAYHTRIVRVCSSD---.-----.SELRSYIEMPLECIFTEKrrkrsta..GAVFNILQAAYLGRAG..E
ENSXETP00000040369  tspDSTGEQFFTSKIVRLCVDD---.-----.PKFYSYVEFPIGCIKDGV.........E--YRLIQDAYLSKPG..K
ENSXETP00000039399  ...YDFFEKMTVARVARVCKNDVGG.EKVLQ.KRWTTFLKAQLTCSLQN-.........HFPFNILHHVALQNQP..D
ENSXETP00000025005  ppgSATKEQVYTSKLVRLCKED---.-----.TAFNSYVEVPIGCEKNGV.........E--YRLLQAAYLSKAG..S
ENSXETP00000015919  ...L---SNTYHSRVVRLSKNE---.-----.EEMRSYRELILECRLEPKrrrrrrraePKIFNVLKAAHVATVG..S
ENSXETP00000007320  tllDATGEKFFTSKIVRMCSGD---.-----.LEFYSYVEFPIGCTKDGV.........E--YRLIQSAYLSRPG..R
ENSXETP00000038644  ...S--QSREYKTYISRICPND---.-----.SHYYSYVELPLSCRTKDK.........S--YNLLQAAYVTQPG..E
ENSXETP00000048152  ...--RISNENRTFISRLCKDD---.-----.FNYYSYIEMPLECKNQRNne.......SKPGSDLADIMKLPST..E
ENSXETP00000017222  ...-----------IARVCPNDIGG.QRSLV.NKWTTFLKARLVCSVMDDdgt......ETYFDELEDVFLMETD..N
ENSXETP00000016825  ...S---QMDYNTYLGSVCTGD---.-----.VHLYSYVEVPLVCQGG--.........---YNLAQAAYLETGN..R
ENSXETP00000059362  ...VR-STEKRISMVARMCKEDSGP.TKLSSyYMFSTALKSRLICGYPKK.........GQYFPHLQDVFLLKGK..E
ENSXETP00000061727  ...----------------------.-----.------LKSRLICGYPKK.........GQYFPHLQDVFLLKGK..E
ENSXETP00000059887  ...VR-STEKRISMVARMCKEDSGP.TKLSSyYMFSTALKSRLICGYPKK.........GQYFPHLQDVFLLKGK..E
ENSXETP00000040366  ...----------------------.-----.------------------.........----------------..-
ENSXETP00000003087  ...----------------------.-----.------------------.........----------------..-
ENSXETP00000003091  ...----------------------.-----.------------------.........----------------..-
ENSXETP00000051361  ...----------------------.-----.------------------.........----------------..-
ENSXETP00000038482  ...----------------------.-----.------------------.........----------------..-


                                      290               300       310       320               330   
                                        |                 |         |         |                 |   
d1olza2               L.........KVPVFYALFT....PQLN....NVGLSAVCAYNLSTAEEVFSHGKYMQSTT....VEQSH....TKWV
ENSXETP00000031145  P.........KNPVVYAVFT....TSSN....IFKGSAVCMYSLADIRRVFLGP----YAH....RDGPN....YQWV
ENSXETP00000015932  N.........KNPVIYAVFS....SSGS....VFKGSAVCVYSMSDIRMVFNGP----FAH....KEGPN....YQWM
ENSXETP00000015948  R.........RNPLIYALFS....TSSS....VFRGSAICVYTMNDVRRAFLGP----FAH....KEGPN....YQWV
ENSXETP00000011952  D.........RNPVVYGIFT....TTSS....IFKASAVCVYSMADIRAVFNGP----YAH....KESPD....HRWV
ENSXETP00000059604  N.........KNPVIYAVFS....SSGS....VFKGSAVCVYSMSDIRMVFNGP----FAH....KEGPN....YQWM
ENSXETP00000017224  P.........RTTLVYGIFT....TSSS....VFKGSAVCVYHMSDIQTVFNGP----FAH....KEGPN....HQLI
ENSXETP00000015621  K.........QNPLIYGVFT....TLGS....VFRGSAVCVYSLADVRAVFNGP----FAH....KEGHG....YQMT
ENSXETP00000049036  K.........QNPLIYGVFT....TLGS....VFRGSAVCVYSLADVRAVFNGP----FAH....KEGHG....YQMT
ENSXETP00000059989  S.........SEPKIYGVFT....SHLN....NVGLSAVCAYNVSTVEEVFAKGKYMHSAT....VEQSN....TKWV
ENSXETP00000023736  S.........SEPKIYGVFT....SHLN....NVGLSAVCAYNVSTVEEVFAKGKYMHSAT....VEQSN....TKWV
ENSXETP00000060752  N.........KNPEIFALFS....TTSN....IFKGYAICVYHMASIREAFNGP----FAH....KEGPE....YHWS
ENSXETP00000002701  W.........RSTQFFAAFQ....ARWG....DSPVSAVCQYSIHDIQKVFDGP----YKE....YREQS....QKWG
ENSXETP00000028414  W.........KSTIFYGVFT....SQWNkg..GAGSSAVCAFSMDEVQNAFNGL----FKE....VNRET....QQWY
ENSXETP00000040545  G.........R-DVVLATFS....TPYN....SIPGSAVCAYDMADIASVFTGR----FKE....QKSPD....STWT
ENSXETP00000033273  W.........DTTIFYGAFI....LQWK....NMEESAICRYSISDIQKVFEGP----YME....YQYSS....RKWS
ENSXETP00000039840  G.........I-PTVVGVFT....TQLN....SIPGSAVCAFTMDDIEKVFRGR----FKE....QKTPD....SVWT
ENSXETP00000039837  G.........I-PTVVGVFT....TQLN....SIPGSAVCAFTMDDIEKVFRGR----FKE....QKTPD....SVWT
ENSXETP00000012836  N.........R-PAVIGVFG....TQAN....SITGSGVCAYYMDDIEKVFNGK----FKE....QKTTE....SAWT
ENSXETP00000047775  G.........R-QVVLALFS....TPTN....SIPGSAVCVFDMEQVASVFSGR----FRE....QRSPD....SVWT
ENSXETP00000047038  DlaeemgvkpDDDILYAVFAqsklDSSE....ANNRSAVCAVSVKTINEFFNNA----ADK....QNTKC....LEHF
ENSXETP00000040369  RlakelgiseREDILFTVFS....QGQKnrikPPKESVMCLFTLKKIKDKIKERIQSCYRG....DGKLS....LPWL
ENSXETP00000039399  P.........NNSIFFGVFR....TQWQlg..GRRSSAVCLYKLNDIEKVFNGA----FKE....QNKES....SKWN
ENSXETP00000025005  IlakslgikpGDDILFTIFS....KGQKrklnSLDESALCVFVLKDINNRIKERLQSCYKG....EGTLD....LAWL
ENSXETP00000015919  TlageldiseKDPVLFAVFA....QSEPksaqPRYNSAVCAFPLRLIDLSIEDGMNACCSN....TNSVRltrgLNFF
ENSXETP00000007320  KlaqalgipeDEEVLFTVFS....QGQKnrsnPPRESVLCLFTLSQINLHIKMRIQSCYHG....EGKLS....LPWL
ENSXETP00000038644  Rlakgvlkt.DGDVLFAAFS....QWQAasgkVGEESGLCLYSMDLIDRLINQTRDTCYTKdgkaEDGRE....VAYI
ENSXETP00000048152  -.........-TTVLFGVFS....RKQ-....VSDQSAVCVFSLSEINNKFEENREACYTSnk..ADLKT....LFFK
ENSXETP00000017222  P.........RTTLVYGIFT....TSSS....VFKGSAVCVYHMSDIQTVFNGP----FAH....KEGPN....HQLI
ENSXETP00000016825  -.........---ELFVVFA....ASQGptpnPSSRTALCSYKMVDIESRIENAREMCYTN....AGMLF....LCWC
ENSXETP00000059362  E.........--NLIYGLFT....NAWN....---HSAVCSYNLLDIEKTFSSSSLWNA--....-----....----
ENSXETP00000061727  E.........--NLIYGLFT....NAWN....---HSAVCSYNLLDIEKTFSSSSLWNA--....-----....----
ENSXETP00000059887  E.........--NLIYGLFT....NAWN....---HSAVCSYNLLDIEKTFSSS-------....-----....----
ENSXETP00000040366  -.........----------....----....----SVMCLFTLKKIKDKIKERIQSCYRG....DGKLS....LPWL
ENSXETP00000003087  -.........----------....----....-----------------------------....-----....----
ENSXETP00000003091  -.........----------....----....-----------------------------....-----....----
ENSXETP00000051361  -.........-----AGIFT....SQSQam..SPDKTALCIYNLTNMMKQ-----------....-----....----
ENSXETP00000038482  -.........----------....----....-----------------------------....-----....----


                           340       350         360           370       380       390         400  
                             |         |           |             |         |         |           |  
d1olza2               RYN.GPVPKPRPGACIDSEARAA..NYTSSLNLPDKTL....QFVKDHPLMDDSVTPIDNRPRLIKKD..VNYTQIVV
ENSXETP00000031145  PFQ.GRVPYPRPGTCPSK--TFG..GFDSTKDLPDEVI....MFARSHPAMYNPVFPINNRPIIIKTEvdYQFTQIVV
ENSXETP00000015932  PYT.GKIPYPRPGTCPGG-TFTP..SMKSTKDYPDEVI....NFMRTHPVMYNPVYPVHRQPLLVRTNvnYRFTTIAV
ENSXETP00000015948  SYQ.GKVPYPRPGMCPSK--TFG..SFESTKSFPDDVL....QFARNHPLMFNPVVPGSGRPVFLRSHgdLSFTQLAV
ENSXETP00000011952  QYD.GRIPYPRPGTCPSK-TYDP..TIRSTKDFPDDVI....NFVKNHPLMYKAVYPLHGKPVFTRLNvdYKLTQIAV
ENSXETP00000059604  PYT.GKIPYPRPGTCPGG-TFTP..SMKSTKDYPDEVI....NFMRTHPVMYNPVYPVHRQPLLVRTNvnYRFTTIAV
ENSXETP00000017224  PYQ.GRIPYPRPGTCPGG-AFTP..NMKSTKEFPDDVV....TFIRNHPLMFNSIYPTLKRPLLIRTGtdYKFTKIVV
ENSXETP00000015621  AYS.GKTPYPRPGACAGG-FSVP..RNRSSRNFGEDVL....RFVRTHPLMYSSVYPVNRRPLLLLSDasYTYTSIAV
ENSXETP00000049036  AYS.GKTPYPRPGACAGG-FSVP..RNRSSRNFGEDVL....RFVRTHPLMYSSVYPVNRRPLLLLSDasYTYTSIAV
ENSXETP00000059989  RYN.GEVPKPRPGACINNEARAM..NYTSSLNLPDMTL....QFVKDHPLMDDSVSPVGNKPKLVLRD..VIYTQIVV
ENSXETP00000023736  RYN.GEVPKPRPGACINNEARAM..NYTSSLNLPDMTL....QFVKDHPLMDDSVSPVGNKPKLVLRD..VIYTQIVV
ENSXETP00000060752  IYE.GKIPYPRPGLCASK-VNGG..HYGTTKDYPDEAL....RFARSHPLMYESVKPTHKKPILIKADgkYNLKQIAV
ENSXETP00000002701  RYS.DSVPSPRPGSCITNWHRNH..GVYSSLELPDNTL....NFVKKHPLMDDTVMPSQGRPLLVRRG..INFTTIAV
ENSXETP00000028414  TYT.NSVPEPRPGACITNSARDK..KINSSLQMPDRVL....NFVKDHFLMDSAI---RSQPLLLQSQ..IRYQQISV
ENSXETP00000040545  PVPdERVPKPRPGCCAGS-ATVE..RITKSNELPDDTL....NFIKTHPLMDEAVPSVINRPLFLRTMvrYRLTKIAV
ENSXETP00000033273  RYE.GEVPSPRPGSCITNEFRMN..GFNTSQDLPNNVL....DFVKLHPLMYEKVRPVGEQPLLVKKN..IIYTRIAV
ENSXETP00000039840  AVPeDRVPKPRPGCCARH-GYGE..GYRSSTEFPDETL....SFIKSHPLMDSAIPSIIEEPWFTKTRvrYRLTAVAV
ENSXETP00000039837  AVPeDRVPKPRPGCCARH-GYGE..GYRSSTEFPDETL....SFIKSHPLMDSAIPSIIEEPWFTKTRvrYRLTAVAV
ENSXETP00000012836  PIPeDKVPTPRPGCCAGY-GKAA..TYKTSNEFPDETL....SFIKSYPLLDEAVLSITETPWFTKTTsrFKLTHLAA
ENSXETP00000047775  PVPeELVPRPRPGCCVGH---SH..PYNSSRSLPDEVL....NFVKSHPLMEDSVPSIGGFPWITRTLtrNQLTHLAV
ENSXETP00000047038  YEK.D------NRLCINNKKFLR..NASYCST-P----....--IDEYRVEVTTVLRRLDLFMDQFRN..VLLTSISV
ENSXETP00000040369  LNK.EL-------GCINS-PLQI..DDNFCG-------....---QDFNQPLGGTVTIEGTPLFLDKE..DGMTSVAA
ENSXETP00000039399  RYM.GVVSDPRPGSCSGG-----..------KFSDTDL....NFMKEHFLMDEVVSPGAGRPVLVKQN..VQYTRIAL
ENSXETP00000025005  KVKdIP--------CGNA-LITI..ADDFCGL------....----DMNAPLGVSEMVRGLPVFTEDR..DRMTSVIA
ENSXETP00000015919  QPE.MD--------CPQ--KDNQ..SDTSCKNVPTLVL....PPLRRVDIFNGQL-----------DG..VLLTSVYV
ENSXETP00000007320  LNK.EL-------FCISTPIRIHdgFCGLALNQPIGGL....QVIEGIPLLEEKVDGMASV-------..--------
ENSXETP00000038644  EYD.VK-----------------..--SNCVQLPSDTLdaypWGWDHTPSPMASKDPREATPLFESVT..TGFTAIAG
ENSXETP00000048152  PYG.GELS------CANS-----..----PSGAAKSYR....CGSEHLPYPLECKEGVSKSSVLIREK..NPFSSVAI
ENSXETP00000017222  PYQ.GRIPYPRPGTCPGG-AFTP..NMKSTKEFPDDVV....TFIRNHPLMFNSIYPTLKRPLLIRTGtdYKFTKIVV
ENSXETP00000016825  LQP.IP-----------------..--ASDQDTPQLFQ....CGGEHTPSPIASRVPVEATPLLKDLS..-SLTAVAA
ENSXETP00000059362  --P.ASNLAIRPGTCILGD----..------RTPEDTF....NRASKYPELQDWIEPSGKEAVFQNLS..H-YRKIVV
ENSXETP00000061727  --P.ASNLAIRPGTCILGD----..------RTPEDTF....NRASKYPELQDWIEPSGKEAVFQNLS..H-YRKIVV
ENSXETP00000059887  ---.-------------------..-------------....--------------------------..--------
ENSXETP00000040366  LNK.EL-------GCINS-PLQI..DDNFCG-------....---QDFNQPLGGTVTIEGTPLFLDKE..DGMTSVAA
ENSXETP00000003087  ---.-------------------..-------------....-----------------AVP--IYKE..KGLTSVAV
ENSXETP00000003091  ---.-------------------..-------------....-----------------AVP--IYKE..KGLTSVAV
ENSXETP00000051361  ---.-------EKECIAEDFRVG..TKKQCKE------....------NQRKKRILPINLGPTLTHGNl.S---AVFA
ENSXETP00000038482  ---.-------------------..-------------....--------------------------..--------


                           410       420       430                  440                450        46
                             |         |         |                    |                  |          
d1olza2               DRTQALDGTVYDVMFVSTDRGALHKAISLEHA...........VHIIEETQLFQD.........FEPVQT.LLLSSKK
ENSXETP00000031145  DRVEAEDGQ-YDVMFIGTDMGTVLKVVSVPKEtwhdle.....EVLLEEMTVFRE.........PTAISA.MEISTK-
ENSXETP00000015932  DQVDASDGR-YEVLFLGTDKGTVQKVIVLPKDdlete......ELILEEVEVFKV.........PAPIKS.MKISTK-
ENSXETP00000015948  DRVAAADGE-YDVMFIGTDVGSVLKVISVPKQswhhve.....QVVLEELQVFKN.........ASPITT.MQISSK-
ENSXETP00000011952  DHVVAEDGQ-YDVMFLGTDIGTVLKVITVTKDiwnme......EVLLEEMQIFKQ.........PAAITN.IELSLK-
ENSXETP00000059604  DQVDASDGR-YEVLFLGTDKGTVQKVIVLPKDdlete......ELILEEVEVFKV.........PAPIKS.MKISTK-
ENSXETP00000017224  DRVNAADGK-YHVLFLGTDKGTVQKVVVVPANgsasg......ELILEEMEVFKS.........HAPITS.MKISSK-
ENSXETP00000015621  DRVPAADGE-YTVLFLGTDRGTVQKVMILPRGtkete......SITLEEVEVFKV.........PSPIRN.LRISSK-
ENSXETP00000049036  DRVPAADGE-YTVLFLGTDRGTVQKVMILPRGtkete......SITLEEVEVFKV.........PSPIRN.LRISSK-
ENSXETP00000059989  DRVKALDGNSYDIMFLSTDKGILHKAVSQDAE...........MRIIEEIVLFPH.........LQPVQT.LLLSNKE
ENSXETP00000023736  DRVKALDGNSYDIMFLSTDKGILHKAVSQDAE...........MRIIEEIVLFPH.........LQPVQT.LLLSNKE
ENSXETP00000060752  DRVEAEDGQ-YHVVFIGTDNGIVLKVITIYNQetetme.....EVILEELQVFKV.........PDPIIS.MEISAK-
ENSXETP00000002701  QRTLGLDKEPYDVLFIGTDNGWVNKAVSFGST...........VHIIEELQVFDK.........SYPVNS.LAVSSR-
ENSXETP00000028414  QRVRGLKKT-YDVLFLGTDDGRLHKAVSVNKM...........VHIIEEIKLFQD.........MQPVQE.LLLDPS-
ENSXETP00000040545  DTAAGPYQN-HTVVFLGSERGIVLKFLARTGYsgflsd.....SLFLEEMNVYNSekcsfdgaeDKRILG.MQLDKH-
ENSXETP00000033273  DRVKALNDEYYDVLFLGTDDGWIHKAVVIGSM...........VHIIEEIQVYKF.........PQPVEN.LVISKK-
ENSXETP00000039840  DHLAGPYLN-YTVMFVGSEAGVVLKILAKTNPfslnd......SVLLEEIDAYNRakcsgnseeDRKVIS.LQMDRD-
ENSXETP00000039837  DHLAGPYLN-YTVMFVGSEAGVVLKILAKTNPfslnd......SVLLEEIDAYNRakcsgnseeDRKVIS.LQMDRD-
ENSXETP00000012836  DTSAGPYGN-YTVLFLGSEDGKVLKVLSGTTEnstve......TLLLEDINVYNPakcnvkke.DRRILG.LQLDRE-
ENSXETP00000047775  DASSGVHGN-HTVLFLASDSGTVLKYLLIPKMsgseigtlanqTVLLEELQTYPAnrcgwdee.DQKILG.IEVDKG-
ENSXETP00000047038  FTQGR-----LTIANLGTSEGRFMQVVISRTGqpkph......VNFLLEPRPVSP.........E--VVI.NPASEE-
ENSXETP00000040369  YDYRG-----HTVVFAGTRSGRMKKILVDLSAsshm.......AQQYENVVVHEG.........NAILRD.LVLSPD-
ENSXETP00000039399  DSVQSVSGLNYTVMFLGTDKGFLHKAVLMGNGse.........SHIIEEIELLTP.........EEPVEN.ILLAAN-
ENSXETP00000025005  YVYKN-----HSLAFVGTKSGKLKKIRVDGTEsg.........AVQYETIQVVDS.........GPILRD.MAFTKN-
ENSXETP00000015919  SPQED-----LTIGFLGTSAGRLLQVVLQRNS...........NPRTLSNFSISD.........NYPVSR.EVTQI--
ENSXETP00000007320  ---AAYSYNEHSVVFVGTRAGTLKKIRVDSPTd..........VTLYESVPVVLG.........KPILRD.MVFSPD-
ENSXETP00000038644  HGEGE-----HTIAFIGDSKGYLKRVYLGGEQd..........TRQYSSVGTQSN.........SAVLPD.LLFDQE-
ENSXETP00000048152  AVENE-----HTIAFLGTAEGKLVKVIIMPKD...........QSYEYRNLSFET.........SSAVKNgMVFDAD-
ENSXETP00000017222  DRVNAADGK-YHVLFLGTDKGTVQKVVVVPANgsasg......ELILEEMEVFKS.........HAPITS.MKISSK-
ENSXETP00000016825  LAEDT-----YTIAFLGDAAGNIHKLEVP---...........------------.........------.-------
ENSXETP00000059362  DEVKALDGNSYRVILL----------------...........------------.........------.-------
ENSXETP00000061727  DEVKALDGNSYRVILLAAAGGSVQKLVVMDNG...........DHSVHMINPFNE.........TKEILS.LILEPT-
ENSXETP00000059887  --------------------------------...........------------.........------.-------
ENSXETP00000040366  YDYRG-----HTVVFAGTRSGRMKKILVDLSAsshm.......AQQYENVVVHEG.........NAILRD.LVLSPD-
ENSXETP00000003087  ANVSG-----YMVVFLGNVSGHLIKINLDADM...........KIINKSMQYLEIas.......GQPVHH.VMEFDPM
ENSXETP00000003091  ANVSG-----YMVVFLGNVSGHLIKINLDADM...........KIINKSMQYLEIas.......GQPVHH.VMEFDPM
ENSXETP00000051361  VEVQN-----KMVFFLGTGNGQVLKVTLDSEWk..........ANCPEILFQFDN.........DTAVSR.TIKADPV
ENSXETP00000038482  --------------------------------...........------------.........---LRD.MAFSTD-


                      0       470               
                      |         |               
d1olza2               GNRFVYAGSNSGVVQAPL-a......
ENSXETP00000031145  -QQQLYIGSSVGVSQLPLHrcdvy..
ENSXETP00000015932  -RQQLYVASMSGVTHVALHrcdvy..
ENSXETP00000015948  -RQQIYVGSASGISQLPLHrcgiy..
ENSXETP00000011952  -QQQLYITSEVGLVQLSLHrcdty..
ENSXETP00000059604  -RQQLYVASMSGVTHVALHrcdvy..
ENSXETP00000017224  -KQQLYVSSEEGITQLSLHrchiy..
ENSXETP00000015621  -RHQLYVSSDVGVTQLSLHrcgry..
ENSXETP00000049036  -RHQLYVSSDVGVTQLSLHrcgry..
ENSXETP00000059989  GKRFIYAGSNTGVVQSPL-.......
ENSXETP00000023736  GKRFIYAGSNTGVVQSPL-.......
ENSXETP00000060752  -RQQLYIGSASSIVQIK--thqcemy
ENSXETP00000002701  -KSLLYVGSQSGLVQLP--f......
ENSXETP00000028414  -KGLIYASSRSAVVQVPV-sncsmy.
ENSXETP00000040545  -NNALYVAFSTCVVSVPLArcdrh..
ENSXETP00000033273  -QNALYIGAQSGVLQIPL-.......
ENSXETP00000039840  -HHALFVAFSGCIVRLPL-srcery.
ENSXETP00000039837  -HHALFVAFSGCIVRLPL-srcery.
ENSXETP00000012836  -NHALFVAFSSCIIRVPL-srcely.
ENSXETP00000047775  -SGSLLLAYSSCIVKVPLArcqrh..
ENSXETP00000047038  -SGYTLVNTGMQLTKVP--l......
ENSXETP00000040369  -RQYIYAMTEKQVTRVPV-.......
ENSXETP00000039399  -EGVLYIGYSAGVLRVPLAnctvy..
ENSXETP00000025005  -EEQLFIMSDKQLTRVPV-.......
ENSXETP00000015919  -GDSLFFVTGNQVTKVN--i......
ENSXETP00000007320  -WQSIYILSEKQVSKVPV-.......
ENSXETP00000038644  -EKHLYILTQSTVMKVPL-.......
ENSXETP00000048152  -QKHLYVMTKKKAYRVPV-.......
ENSXETP00000017222  -KQQLYVSSEEGITQLSLHrchiy..
ENSXETP00000016825  -------------------sps....
ENSXETP00000059362  -------------------aa.....
ENSXETP00000061727  -MHVLYVGTNTEVIRLPL-ddctay.
ENSXETP00000059887  -------------------.......
ENSXETP00000040366  -RQYIYAMTEKQVTRVPV-.......
ENSXETP00000003087  DPTYLFVMTSHQMTRVKV-.......
ENSXETP00000003091  DPTYLFVMTSHQMTRVKV-.......
ENSXETP00000051361  NSTYIYVAAENKIKRIKV-.......
ENSXETP00000038482  -NKYLYVMSERQVSRVEV-ehceqy.


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Refine alignments

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Include all superfamily members: , or just those assigned by the selected model:
Initial T99 seed sequence: NoYes

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Model: 0048597 (list models)
Initial SAMT99 seed:
Alignment:



Display Options:
Output in FASTA-like format: NoYes
Output column indices: NoYes
Sequence index (number) on each line: NoYes

Max number of insertions shown: (0 does not show insertions)
Characters per line:
Character to show inserts:
Maximum number of sequences:
Exclude sequences shorter than: residues



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Add alignments from genomes

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Select to display   Genome
NoYes   Danio rerio 58 (pseudogenes) - Zebrafish
NoYes   Gallus gallus 58 (pseudogene) - Chicken
NoYes   Homo sapiens 58 (pseudogenes) - Human
NoYes   Homo sapiens 76_38 - Human
NoYes   Pan troglodytes 76_2.1.4 - Chimpanzee
NoYes   Gorilla gorilla 76_3.1 - Western gorilla
NoYes   Pongo abelii 76_2 - Sumatran orangutan
NoYes   Tarsius syrichta 76_1
NoYes   Nomascus leucogenys 76_1.0 - Northern white-cheeked gibbon
NoYes   Papio anubis 76 - Olive baboon
NoYes   Macaca mulatta 76_1 - Rhesus monkey
NoYes   Callithrix jacchus 76_3.2.1 - White-tufted-ear marmoset
NoYes   Otolemur garnettii 76_3 - Small-eared galago
NoYes   Microcebus murinus 76_1 - Gray mouse lemur
NoYes   Rattus norvegicus 76_5.0 - Norway rat
NoYes   Mus musculus 76_38 - House mouse
NoYes   Dipodomys ordii 76_1 - Ord's kangaroo rat
NoYes   Ictidomys tridecemlineatus 76_2 - Thirteen-lined ground squirrel
NoYes   Heterocephalus glaber v1.7-2 - Naked mole-rat
NoYes   Cavia porcellus 76_3 - Domestic guinea pig
NoYes   Oryctolagus cuniculus 76_2 - Rabbit
NoYes   Ochotona princeps 76 - American pika
NoYes   Tupaia belangeri 76 - Northern tree shrew
NoYes   Sus scrofa 76_10.2 - Pig
NoYes   Bos taurus 76_3.1 - Cattle
NoYes   Ovis aries 76_3.1 - Sheep
NoYes   Vicugna pacos 76_1 - Alpaca
NoYes   Tursiops truncatus 76_1 - Bottlenose dolphin
NoYes   Mustela putorius furo 76_1.0 - Domestic ferret
NoYes   Ailuropoda melanoleuca 76_1 - Giant panda
NoYes   Canis familiaris 76_3.1 - Dog
NoYes   Felis catus 76_6.2 - Domestic cat
NoYes   Equus caballus 76_2 - Horse
NoYes   Myotis lucifugus 76_2.0 - Little brown bat
NoYes   Pteropus vampyrus 76_1 - Large flying fox
NoYes   Sorex araneus 76_1 - European shrew
NoYes   Erinaceus europaeus 76 - Western European hedgehog
NoYes   Procavia capensis 76_1 - Cape rock hyrax
NoYes   Loxodonta africana 76_3 - African savanna elephant
NoYes   Echinops telfairi 76 - Small Madagascar hedgehog
NoYes   Dasypus novemcinctus 76_2 - Nine-banded armadillo
NoYes   Choloepus hoffmanni 76_1 - Hoffmann's two-fingered sloth
NoYes   Macropus eugenii 76_1.0 - Tammar wallaby
NoYes   Sarcophilus harrisii 76_7.0 - Tasmanian devil
NoYes   Monodelphis domestica 76_5 - Gray short-tailed opossum
NoYes   Ornithorhynchus anatinus 76_5 - Platypus
NoYes   Saccoglossus kowalevskii v3.0
NoYes   Petromyzon marinus 76_7.0 - Sea lamprey
NoYes   Meleagris gallopavo 76_2 - Turkey
NoYes   Gallus gallus 76_4 - Chicken
NoYes   Anas platyrhynchos 76_1.0 - Mallard
NoYes   Taeniopygia guttata 76_3.2.4 - Zebra finch
NoYes   Ficedula albicollis 76_1.0 - Collared flycatcher
NoYes   Pelodiscus sinensis 76_1.0 - Chinese soft-shelled turtle
NoYes   Anolis carolinensis 76_2.0 - Green anole
NoYes   Xenopus laevis - African clawed frog
NoYes   Xenopus tropicalis 76_4.2 - Tropical clawed frog
NoYes   Latimeria chalumnae 76_1 - Coelacanth
NoYes   Lepisosteus oculatus 76 - Spotted gar
NoYes   Gadus morhua 76_1 - Atlantic cod
NoYes   Tetraodon nigroviridis 76_8 - Spotted green pufferfish
NoYes   Takifugu rubripes 76_4 - Torafugu
NoYes   Gasterosteus aculeatus 76_1 - Three-spined stickleback
NoYes   Oryzias latipes 76_1 - Japanese medaka
NoYes   Xiphophorus maculatus 76_4.4.2 - Southern platyfish
NoYes   Poecilia formosa 76 - Amazon molly
NoYes   Oreochromis niloticus 76_1.0 - Nile tilapia
NoYes   Astyanax mexicanus 76 - Mexican tetra
NoYes   Danio rerio 76_9 - Zebrafish
NoYes   Oikopleura dioica
NoYes   Ciona savignyi 76_2.0 - Pacific transparent sea squirt
NoYes   Ciona intestinalis 76 - Vase tunicate
NoYes   Strongylocentrotus purpuratus v3.1 - Purple sea urchin
NoYes   Adineta vaga
NoYes   Octopus bimaculoides 280
NoYes   Crassostrea gigas 22 - Pacific oyster
NoYes   Lottia gigantea - Owl limpet
NoYes   Helobdella robusta
NoYes   Capitella sp. I
NoYes   Danaus plexippus OGS1.0 - Monarch butterfly
NoYes   Heliconius melpomene - Postman butterfly
NoYes   Bombyx mori - Domestic silkworm
NoYes   Nasonia vitripennis - Jewel wasp
NoYes   Apis mellifera 38.2d - Honey bee
NoYes   Harpegnathos saltator v3.3 - Jerdon's jumping ant
NoYes   Linepithema humile v1.1 - Argentine ant
NoYes   Pogonomyrmex barbatus v1.2 - Red harvester ant
NoYes   Solenopsis invicta v.2.2.3 - Red fire ant
NoYes   Acromyrmex echinatior v3.8 - Panamanian leafcutter ant
NoYes   Atta cephalotes v1.1
NoYes   Camponotus floridanus v3.3 - Florida carpenter ant
NoYes   Lucilia cuprina - Australian sheep blowfly
NoYes   Drosophila grimshawi 1.3
NoYes   Drosophila willistoni 1.3
NoYes   Drosophila pseudoobscura 2.13
NoYes   Drosophila persimilis 1.3
NoYes   Drosophila suzukii
NoYes   Drosophila yakuba 1.3
NoYes   Drosophila simulans 1.3
NoYes   Drosophila sechellia 1.3
NoYes   Drosophila melanogaster 76_5 - Fruit fly
NoYes   Drosophila erecta 1.3
NoYes   Drosophila ananassae 1.3
NoYes   Drosophila virilis 1.2
NoYes   Drosophila mojavensis 1.3
NoYes   Megaselia scalaris 22
NoYes   Aedes aegypti 55 - Yellow fever mosquito
NoYes   Culex pipiens quinquefasciatus - Southern house mosquito
NoYes   Anopheles darlingi 22 - American malaria mosquito
NoYes   Anopheles gambiae 49_3j - African malaria mosquito
NoYes   Tribolium castaneum 3.0 - Red flour beetle
NoYes   Pediculus humanus corporis - Human body louse
NoYes   Acyrthosiphon pisum - Pea aphid
NoYes   Rhodnius prolixus 22
NoYes   Daphnia pulex - Common water flea
NoYes   Strigamia maritima 22
NoYes   Sarcoptes scabiei
NoYes   Tetranychus urticae - Two-spotted spider mite
NoYes   Ixodes scapularis - Black-legged tick
NoYes   Pristionchus pacificus
NoYes   Meloidogyne incognita - Southern root-knot nematode
NoYes   Meloidogyne hapla
NoYes   Onchocerca volvulus 22
NoYes   Brugia malayi WS250 - Agent of lymphatic filariasis
NoYes   Caenorhabditis japonica
NoYes   Caenorhabditis brenneri
NoYes   Caenorhabditis remanei
NoYes   Caenorhabditis elegans 76_235 - Roundworm
NoYes   Caenorhabditis briggsae 2
NoYes   Trichinella spiralis 22
NoYes   Hymenolepis microstoma
NoYes   Echinococcus multilocularis
NoYes   Echinococcus granulosus
NoYes   Taenia solium - Pork tapeworm
NoYes   Schistosoma mansoni
NoYes   Mnemiopsis leidyi - Sea walnut
NoYes   Acropora digitifera v1.0
NoYes   Nematostella vectensis 1.0 - Starlet sea anemone
NoYes   Hydra vulgaris
NoYes   Amphimedon queenslandica
NoYes   Trichoplax adhaerens
NoYes   Proterospongia sp. ATCC 50818
NoYes   Monosiga brevicollis
NoYes   Xenopus (Silurana) tropicalis v7.1 (annotation v7.2) - Tropical clawed frog
NoYes   Drosophila melanogaster FlyBase 5.12 - Fruit fly
NoYes   Anopheles gambiae VectorBase AgamP3.6 - African malaria mosquito
NoYes   Ascaris suum Victoria/Ghent - Pig roundworm
NoYes   Caenorhabditis elegans WormBase WS218 - Roundworm
NoYes   Homo sapiens 69_37 - Human
NoYes   Pan troglodytes 69_2.1.4 - Chimpanzee
NoYes   Gorilla gorilla 69_3.1 - Western gorilla
NoYes   Pongo abelii 69_2 - Sumatran orangutan
NoYes   Nomascus leucogenys 69_1.0 - Northern white-cheeked gibbon
NoYes   Macaca mulatta 69_1 - Rhesus monkey
NoYes   Callithrix jacchus 69_3.2.1 - White-tufted-ear marmoset
NoYes   Otolemur garnettii 69_3 - Small-eared galago
NoYes   Tarsius syrichta 69_1
NoYes   Microcebus murinus 69_1 - Gray mouse lemur
NoYes   Rattus norvegicus 69_3.4 - Norway rat
NoYes   Mus musculus 69_38 - House mouse
NoYes   Dipodomys ordii 69_1 - Ord's kangaroo rat
NoYes   Ictidomys tridecemlineatus 69_2 - Thirteen-lined ground squirrel
NoYes   Cavia porcellus 69_3 - Domestic guinea pig
NoYes   Oryctolagus cuniculus 69_2 - Rabbit
NoYes   Ochotona princeps 69 - American pika
NoYes   Tupaia belangeri 69 - Northern tree shrew
NoYes   Sus scrofa 69_10.2 - Pig
NoYes   Bos taurus 69_3.1 - Cattle
NoYes   Vicugna pacos 69_1 - Alpaca
NoYes   Tursiops truncatus 69_1 - Bottlenose dolphin
NoYes   Mustela putorius furo 69_1.0 - Domestic ferret
NoYes   Ailuropoda melanoleuca 69_1 - Giant panda
NoYes   Canis familiaris 69_3.1 - Dog
NoYes   Felis catus 69 - Domestic cat
NoYes   Equus caballus 69_2 - Horse
NoYes   Myotis lucifugus 69_2.0 - Little brown bat
NoYes   Pteropus vampyrus 69_1 - Large flying fox
NoYes   Sorex araneus 69_1 - European shrew
NoYes   Erinaceus europaeus 69 - Western European hedgehog
NoYes   Procavia capensis 69_1 - Cape rock hyrax
NoYes   Loxodonta africana 69_3 - African savanna elephant
NoYes   Echinops telfairi 69 - Small Madagascar hedgehog
NoYes   Dasypus novemcinctus 69_2 - Nine-banded armadillo
NoYes   Choloepus hoffmanni 69_1 - Hoffmann's two-fingered sloth
NoYes   Macropus eugenii 69_1.0 - Tammar wallaby
NoYes   Sarcophilus harrisii 69_7.0 - Tasmanian devil
NoYes   Monodelphis domestica 69_5 - Gray short-tailed opossum
NoYes   Ornithorhynchus anatinus 69_5 - Platypus
NoYes   Petromyzon marinus 69_7.0 - Sea lamprey
NoYes   Meleagris gallopavo 69_2 - Turkey
NoYes   Gallus gallus 69_2 - Chicken
NoYes   Taeniopygia guttata 69_3.2.4 - Zebra finch
NoYes   Pelodiscus sinensis 69_1.0 - Chinese soft-shelled turtle
NoYes   Anolis carolinensis 69_2.0 - Green anole
NoYes   Xenopus tropicalis 69_4.2 - Tropical clawed frog
NoYes   Latimeria chalumnae 69_1 - Coelacanth
NoYes   Gadus morhua 69_1 - Atlantic cod
NoYes   Tetraodon nigroviridis 69_8 - Spotted green pufferfish
NoYes   Takifugu rubripes 69_4 - Torafugu
NoYes   Gasterosteus aculeatus 69_1 - Three-spined stickleback
NoYes   Oryzias latipes 69_1 - Japanese medaka
NoYes   Xiphophorus maculatus 69_4.4.2 - Southern platyfish
NoYes   Oreochromis niloticus 69_1.0 - Nile tilapia
NoYes   Danio rerio 69_9 - Zebrafish
NoYes   Ciona savignyi 69_2.0 - Pacific transparent sea squirt
NoYes   Ciona intestinalis 69 - Vase tunicate
NoYes   Drosophila melanogaster 69_5 - Fruit fly
NoYes   Caenorhabditis elegans 69_215 - Roundworm
NoYes   Homo sapiens 75_37 - Human
NoYes   Homo sapiens - Human
NoYes   Mus musculus 63_37 (longest transcript per gene) - House mouse
NoYes   Heliconius numata
NoYes   Loa loa v3.3 - Eye worm
NoYes   Wuchereria bancrofti v1.0 - Agent of lymphatic filariasis
NoYes   Brugia malayi v1.0 - Agent of lymphatic filariasis
NoYes   Nicotiana benthamiana 0.4.4
NoYes   NCBI 2017_08 genome
NoYes   STRING v9.0.5 (STRING)
NoYes   Uniprot 2018_03 genome
NoYes   NCBI viral sequences (Viral)
NoYes   PDB chains (SCOP 1.75) (PDB)
NoYes   Protein Data Bank (all PDB sequenc)
NoYes   SCOP2 SCOPe CATH ECOD (all domain sequ)
NoYes   TargetDB (Targets)
NoYes   UniProt viral sequences (Viral)
NoYes   ALL (only advised for small superfamilies)


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