All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 20 | 10 | |
ABC transporter transmembrane region | P-loop containing nucleoside triphosphate hydrolases | 14 | 1 | |
Actin-like ATPase domain | Actin-like ATPase domain | 9 | 3 | |
Calcium ATPase, transmembrane domain M | HAD-like | 8 | 3 | |
Calcium ATPase, transduction domain A | HAD-like | 8 | 3 | |
Calcium ATPase, transduction domain A | Calcium ATPase, transmembrane domain M | 8 | 3 | |
"Winged helix" DNA-binding domain | Periplasmic binding protein-like II | 7 | 1 | |
Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 6 | 6 | |
MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, peptide-binding domain | 6 | 3 | |
Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 6 | 1 | |
Homodimeric domain of signal transducing histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 6 | 4 | |
PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 6 | 3 | |
CheY-like | C-terminal effector domain of the bipartite response regulators | 6 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 6 | 5 | |
Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 5 | 3 | |
NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 4 | 2 | |
Translation proteins | EF-G C-terminal domain-like | 4 | 3 | |
P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 4 | 3 | |
P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 4 | 4 | |
Nucleic acid-binding proteins | Nucleic acid-binding proteins | 4 | 3 | |
Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 4 | 1 | |
MetI-like | Periplasmic binding protein-like II | 4 | 2 | |
Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 4 | 1 | |
Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 4 | 1 | |
Creatinase/prolidase N-terminal domain | Creatinase/aminopeptidase | 3 | 1 | |
HAMP domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 3 | 2 | |
Sigma2 domain of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 3 | 2 | |
HAMP domain-like | Homodimeric domain of signal transducing histidine kinase | 3 | 2 | |
Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 3 | 3 | |
ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 3 | 3 | |
L30e-like | alpha/beta knot | 3 | 1 | |
ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 3 | 3 | |
Thiolase-like | Thiolase-like | 3 | 1 | |
Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 3 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Restriction endonuclease-like | 3 | 3 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 3 | 2 | |
Nucleic acid-binding proteins | Translation proteins SH3-like domain | 3 | 2 | |
Metallo-dependent phosphatases | 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 3 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 3 | 2 | |
PreATP-grasp domain | Rudiment single hybrid motif | 3 | 1 | |
EF-G C-terminal domain-like | EF-G C-terminal domain-like | 3 | 2 | |
Alpha-L RNA-binding motif | Pseudouridine synthase | 3 | 1 | |
NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 3 | 2 | |
"Winged helix" DNA-binding domain | Chorismate lyase-like | 2 | 1 | |
cAMP-binding domain-like | "Winged helix" DNA-binding domain | 2 | 1 | |
Ribosomal protein S5 domain 2-like | Type II DNA topoisomerase | 2 | 1 | |
Phospholipase D/nuclease | Phospholipase D/nuclease | 2 | 2 | |
Enolase N-terminal domain-like | Enolase C-terminal domain-like | 2 | 1 | |
Metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 2 | 2 | |
tRNA-binding arm | Class II aaRS and biotin synthetases | 2 | 1 | |
Carbamoyl phosphate synthetase, large subunit connection domain | Methylglyoxal synthase-like | 2 | 1 | |
DNA/RNA polymerases | Lesion bypass DNA polymerase (Y-family), little finger domain | 2 | 2 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 2 | 2 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 1 | |
Aspartate/glutamate racemase | Aspartate/glutamate racemase | 2 | 1 | |
GreA transcript cleavage protein, N-terminal domain | FKBP-like | 2 | 1 | |
PYP-like sensor domain (PAS domain) | Homodimeric domain of signal transducing histidine kinase | 2 | 2 | |
Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 2 | 1 | |
PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 2 | 1 | |
MurCD N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 1 | |
Glutathione synthetase ATP-binding domain-like | Methylglyoxal synthase-like | 2 | 1 | |
ThrRS/AlaRS common domain | Class II aaRS and biotin synthetases | 2 | 2 | |
Ribonuclease H-like | DNA/RNA polymerases | 2 | 2 | |
MurCD N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 1 | |
Metal cation-transporting ATPase, ATP-binding domain N | HAD-like | 2 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Type II DNA topoisomerase | 2 | 1 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 2 | 2 | |
Calcium ATPase, transduction domain A | Metal cation-transporting ATPase, ATP-binding domain N | 2 | 1 | |
Nucleic acid-binding proteins | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 2 | 2 | |
Metal cation-transporting ATPase, ATP-binding domain N | Calcium ATPase, transmembrane domain M | 2 | 1 | |
PreATP-grasp domain | Methylglyoxal synthase-like | 2 | 1 | |
Galactose-binding domain-like | (Trans)glycosidases | 2 | 2 | |
Penicillin binding protein dimerisation domain | beta-lactamase/transpeptidase-like | 2 | 2 | |
MurE/MurF N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 1 | |
Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 2 | 1 | |
DNA repair protein MutS, domain III | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Triger factor/SurA peptide-binding domain-like | FKBP-like | 2 | 2 | |
Type II DNA topoisomerase | GyrA/ParC C-terminal domain-like | 2 | 1 | |
CBS-domain pair | FAD-binding/transporter-associated domain-like | 2 | 1 | |
(Trans)glycosidases | Galactose mutarotase-like | 2 | 2 | |
ParB/Sulfiredoxin | KorB DNA-binding domain-like | 2 | 1 | |
PLP-binding barrel | Alanine racemase C-terminal domain-like | 2 | 2 | |
PLP-dependent transferases | Ornithine decarboxylase C-terminal domain | 2 | 1 | |
Protein kinase-like (PK-like) | LanC-like | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 1 | |
FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 2 | 2 | |
PreATP-grasp domain | PreATP-grasp domain | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 2 | 2 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 | |
Phospholipase D/nuclease | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Ribosomal protein S5 domain 2-like | EF-G C-terminal domain-like | 2 | 2 | |
NAD(P)-binding Rossmann-fold domains | LDH C-terminal domain-like | 2 | 1 | |
MurE/MurF N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 1 | |
Sigma3 and sigma4 domains of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 2 | 1 | |
Nucleic acid-binding proteins | RuvA domain 2-like | 2 | 2 | |
PYP-like sensor domain (PAS domain) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 2 | 2 | |
Lysozyme-like | beta-lactamase/transpeptidase-like | 2 | 2 | |
Galactose-binding domain-like | Galactose mutarotase-like | 2 | 2 | |
Glucocorticoid receptor-like (DNA-binding domain) | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 2 | 1 | |
PurM N-terminal domain-like | PurM C-terminal domain-like | 2 | 2 | |
Penicillin-binding protein 2x (pbp-2x), c-terminal domain | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | tRNA-binding arm | 1 | 1 | |
5' to 3' exonuclease, C-terminal subdomain | DNA/RNA polymerases | 1 | 1 | |
PheT/TilS domain | Class II aaRS and biotin synthetases | 1 | 1 | |
"Winged helix" DNA-binding domain | C-terminal domain of arginine repressor | 1 | 1 | |
Nucleotidyltransferase | TGS-like | 1 | 1 | |
Ribosomal protein L7/12, oligomerisation (N-terminal) domain | ClpS-like | 1 | 1 | |
"Winged helix" DNA-binding domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | CarD-like | 1 | 1 | |
HD-domain/PDEase-like | TGS-like | 1 | 1 | |
RuvA domain 2-like | BRCT domain | 1 | 1 | |
Thioesterase/thiol ester dehydrase-isomerase | Thioesterase/thiol ester dehydrase-isomerase | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | HRDC-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Pre-protein crosslinking domain of SecA | 1 | 1 | |
Trigger factor ribosome-binding domain | FKBP-like | 1 | 1 | |
PheT/TilS domain | Anticodon-binding domain of PheRS | 1 | 1 | |
Fibronectin type III | Galactose-binding domain-like | 1 | 1 | |
UROD/MetE-like | UROD/MetE-like | 1 | 1 | |
Carbamate kinase-like | ACT-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TGS-like | 1 | 1 | |
LysM domain | Cysteine proteinases | 1 | 1 | |
Nicotinate/Quinolinate PRTase N-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 1 | 1 | |
Invasin/intimin cell-adhesion fragments | PLC-like phosphodiesterases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | RecA protein, C-terminal domain | 1 | 1 | |
Formyltransferase | FMT C-terminal domain-like | 1 | 1 | |
beta-lactamase/transpeptidase-like | Penicillin-binding protein associated domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Helical scaffold and wing domains of SecA | 1 | 1 | |
Bacterial fluorinating enzyme, N-terminal domain | Bacterial fluorinating enzyme, C-terminal domain | 1 | 1 | |
Penicillin binding protein dimerisation domain | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
Class I glutamine amidotransferase-like | LD-carboxypeptidase A C-terminal domain-like | 1 | 1 | |
N-terminal domain of MutM-like DNA repair proteins | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 | |
Nucleic acid-binding proteins | Putative DNA-binding domain | 1 | 1 | |
"Winged helix" DNA-binding domain | Restriction endonuclease-like | 1 | 1 | |
LuxS/MPP-like metallohydrolase | LuxS/MPP-like metallohydrolase | 1 | 1 | |
Phoshotransferase/anion transport protein | PTS system IIB component-like | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 1 | 1 | |
"Winged helix" DNA-binding domain | GAF domain-like | 1 | 1 | |
Ribosomal protein L6 | Ribosomal protein L6 | 1 | 1 | |
Homeodomain-like | Methylated DNA-protein cysteine methyltransferase domain | 1 | 1 | |
THUMP domain-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Smc hinge domain | 1 | 1 | |
FabD/lysophospholipase-like | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 1 | 1 | |
Nucleic acid-binding proteins | PheT/TilS domain | 1 | 1 | |
Nucleic acid-binding proteins | BRCT domain | 1 | 1 | |
Homeodomain-like | SIS domain | 1 | 1 | |
Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | DHS-like NAD/FAD-binding domain | 1 | 1 | |
Class I glutamine amidotransferase-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
Translation proteins | Ribosomal protein S5 domain 2-like | 1 | 1 | |
"Winged helix" DNA-binding domain | LexA/Signal peptidase | 1 | 1 | |
Sensory domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
TTHA1013/TTHA0281-like | Ribbon-helix-helix | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TrpR-like | 1 | 1 | |
Multidrug efflux transporter AcrB transmembrane domain | Bacterial hemolysins | 1 | 1 | |
DNA repair protein MutS, domain III | SMR domain-like | 1 | 1 | |
5' to 3' exonuclease, C-terminal subdomain | Ribonuclease H-like | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | Translation proteins | 1 | 1 | |
CarD-like | TRCF domain-like | 1 | 1 | |
Class II aaRS and biotin synthetases | YbaK/ProRS associated domain | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | GIY-YIG endonuclease | 1 | 1 | |
RuvA domain 2-like | DNA helicase RuvA subunit, C-terminal domain | 1 | 1 | |
DNA repair protein MutS, domain I | DNA repair protein MutS, domain II | 1 | 1 | |
Glycosyl hydrolase domain | Galactose-binding domain-like | 1 | 1 | |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | Tetrahydrobiopterin biosynthesis enzymes-like | 1 | 1 | |
Glutamine synthetase, N-terminal domain | Glutamine synthetase/guanido kinase | 1 | 1 | |
Glycosyl hydrolase domain | Fibronectin type III | 1 | 1 | |
PheT/TilS domain | Putative DNA-binding domain | 1 | 1 | |
Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 1 | 1 | |
Putative DNA-binding domain | Anticodon-binding domain of PheRS | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 1 | 1 | |
Translation proteins | PRC-barrel domain | 1 | 1 | |
Nucleotidylyl transferase | Riboflavin kinase-like | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 1 | 1 | |
Nucleotidyltransferase | Poly A polymerase C-terminal region-like | 1 | 1 | |
Eukaryotic type KH-domain (KH-domain type I) | HD-domain/PDEase-like | 1 | 1 | |
dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Trigger factor ribosome-binding domain | Triger factor/SurA peptide-binding domain-like | 1 | 1 | |
HprK N-terminal domain-like | PEP carboxykinase-like | 1 | 1 | |
lambda repressor-like DNA-binding domains | Periplasmic binding protein-like I | 1 | 1 | |
Obg GTP-binding protein N-terminal domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal UvrC-binding domain of UvrB | 1 | 1 | |
TGS-like | ThrRS/AlaRS common domain | 1 | 1 | |
Sensory domain-like | Homodimeric domain of signal transducing histidine kinase | 1 | 1 | |
alpha/beta-Hydrolases | Galactose-binding domain-like | 1 | 1 | |
Clc chloride channel | TrkA C-terminal domain-like | 1 | 1 | |
Glutamine synthetase/guanido kinase | GatB/YqeY motif | 1 | 1 | |
L9 N-domain-like | Ribosomal protein L9 C-domain | 1 | 1 | |
Class II aaRS and biotin synthetases | C-terminal domain of transcriptional repressors | 1 | 1 | |
Zinc beta-ribbon | DNA primase core | 1 | 1 | |
"Winged helix" DNA-binding domain | HRDC-like | 1 | 1 | |
Nucleotidylyl transferase | tRNA-binding arm | 1 | 1 | |
HD-domain/PDEase-like | ACT-like | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 1 | 1 | |
MFS general substrate transporter | Duplicated hybrid motif | 1 | 1 | |
LysM domain | LysM domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | ACT-like | 1 | 1 | |
PK beta-barrel domain-like | PK C-terminal domain-like | 1 | 1 | |
PTS system fructose IIA component-like | PTS IIb component | 1 | 1 | |
Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 1 | 1 | |
Galactose mutarotase-like | Fibronectin type III | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
Chaperone J-domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
Leukotriene A4 hydrolase N-terminal domain | Metalloproteases ("zincins"), catalytic domain | 1 | 1 | |
Nucleic acid-binding proteins | Anticodon-binding domain of PheRS | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Class I glutamine amidotransferase-like | 1 | 1 | |
Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 | |
PHP14-like | Phospholipase D/nuclease | 1 | 1 | |
PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | FtsH protease domain-like | 1 | 1 | |
DNA repair protein MutS, domain I | DNA repair protein MutS, domain III | 1 | 1 | |
GroEL equatorial domain-like | GroEL-intermediate domain like | 1 | 1 | |
Coiled-coil domain of nucleotide exchange factor GrpE | Head domain of nucleotide exchange factor GrpE | 1 | 1 | |
Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 1 | 1 | |
Homeodomain-like | Tetracyclin repressor-like, C-terminal domain | 1 | 1 | |
PPK N-terminal domain-like | PHP14-like | 1 | 1 | |
"Winged helix" DNA-binding domain | "Winged helix" DNA-binding domain | 1 | 1 | |
PIN domain-like | Ribonuclease H-like | 1 | 1 | |
Ribonuclease H-like | BRCT domain | 1 | 1 | |
Translation initiation factor IF3, N-terminal domain | Translation initiation factor IF3, C-terminal domain | 1 | 1 | |
Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
RmlC-like cupins | Homeodomain-like | 1 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 | |
PK beta-barrel domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | RuvA domain 2-like | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
Pre-protein crosslinking domain of SecA | Helical scaffold and wing domains of SecA | 1 | 1 | |
Nucleotidyltransferase | ACT-like | 1 | 1 | |
UBA-like | Elongation factor Ts (EF-Ts), dimerisation domain | 1 | 1 | |
Adenine nucleotide alpha hydrolases-like | PheT/TilS domain | 1 | 1 | |
ThrRS/AlaRS common domain | Class II aaRS ABD-related | 1 | 1 | |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | Phosphohistidine domain | 1 | 1 | |
Ribonuclease H-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | Putative methyltransferase TM0872, insert domain | 1 | 1 | |
Class II aaRS and biotin synthetases | GAD domain-like | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 1 | 1 | |
beta-lactamase/transpeptidase-like | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | MOP-like | 1 | 1 | |
Translation proteins | Translation proteins | 1 | 1 | |
Class II aaRS and biotin synthetases | Translation proteins | 1 | 1 | |
PurM N-terminal domain-like | PurM N-terminal domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TRCF domain-like | 1 | 1 | |
Resolvase-like | L9 N-domain-like | 1 | 1 | |
Hsp33 domain | HSP33 redox switch-like | 1 | 1 | |
"Winged helix" DNA-binding domain | PRTase-like | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | BRCT domain | 1 | 1 | |
S13-like H2TH domain | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 | |
ValRS/IleRS/LeuRS editing domain | tRNA-binding arm | 1 | 1 | |
Epsilon subunit of F1F0-ATP synthase N-terminal domain | Epsilon subunit of F1F0-ATP synthase C-terminal domain | 1 | 1 | |
Translation proteins | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 | |
Transcription factor NusA, N-terminal domain | Nucleic acid-binding proteins | 1 | 1 | |
YhbC-like, N-terminal domain | YhbC-like, C-terminal domain | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | DNA mismatch repair protein MutL | 1 | 1 | |
Nucleic acid-binding proteins | DNA helicase RuvA subunit, C-terminal domain | 1 | 1 | |
Aminoacid dehydrogenase-like, N-terminal domain | FAD/NAD(P)-binding domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | SMR domain-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Dimeric alpha+beta barrel | 1 | 1 | |
N-terminal domain of DnaB helicase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
TGS-like | Class II aaRS and biotin synthetases | 1 | 1 | |
Nucleic acid-binding proteins | ArfGap/RecO-like zinc finger | 1 | 1 | |
DNA clamp | DNA clamp | 1 | 1 | |
Chaperone J-domain | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 | |
Subtilisin-like | Sialidases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Obg GTP-binding protein C-terminal domain | 1 | 1 | |
Alpha-L RNA-binding motif | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
DNA repair protein MutS, domain II | DNA repair protein MutS, domain III | 1 | 1 | |
Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 | |
L9 N-domain-like | Ribonuclease H-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 1 | 1 | |
RNase III domain-like | dsRNA-binding domain-like | 1 | 1 | |
Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 1 | 1 | |
Regulatory protein AraC | Homeodomain-like | 1 | 1 | |
X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | Galactose-binding domain-like | 1 | 1 | |
Nucleotidylyl transferase | Nucleic acid-binding proteins | 1 | 1 | |
N-utilization substance G protein NusG, N-terminal domain | Translation proteins SH3-like domain | 1 | 1 | |
Class II aaRS and biotin synthetases | Anticodon-binding domain of PheRS | 1 | 1 | |
Nucleotidylyl transferase | Alpha-L RNA-binding motif | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
(Trans)glycosidases | Fibronectin type III | 1 | 1 | |
beta-Galactosidase/glucuronidase domain | (Trans)glycosidases | 1 | 1 | |
Translation proteins | ThrRS/AlaRS common domain | 1 | 1 | |
PA domain | Subtilisin-like | 1 | 1 | |
Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 1 | 1 | |
PDZ domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
FAD-binding/transporter-associated domain-like | FAD-linked oxidases, C-terminal domain | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 1 | 1 | |
FAD-binding/transporter-associated domain-like | Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 1 | 1 | |
TGS-like | Class II aaRS ABD-related | 1 | 1 | |
FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 1 | 1 | |
"Winged helix" DNA-binding domain | NagB/RpiA/CoA transferase-like | 1 | 1 | |
Phosphoenolpyruvate/pyruvate domain | PK C-terminal domain-like | 1 | 1 | |
Prokaryotic type I DNA topoisomerase | Zinc beta-ribbon | 1 | 1 | |
Multidrug efflux transporter AcrB transmembrane domain | Multidrug efflux transporter AcrB transmembrane domain | 1 | 1 | |
ACT-like | ACT-like | 1 | 1 | |
NAD-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 1 | 1 | |
C-terminal UvrC-binding domain of UvrB | RuvA domain 2-like | 1 | 1 | |
Transcription factor NusA, N-terminal domain | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
Nucleic acid-binding proteins | GAD domain-like | 1 | 1 | |
HSP40/DnaJ peptide-binding domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
TPR-like | TPR-like | 1 | 1 | |
GroEL-intermediate domain like | GroEL apical domain-like | 1 | 1 | |
Trypsin-like serine proteases | PDZ domain-like | 1 | 1 | |
TGS-like | ACT-like | 1 | 1 | |
Ribosomal L11/L12e N-terminal domain | Ribosomal protein L11, C-terminal domain | 1 | 1 | |
PIN domain-like | DNA/RNA polymerases | 1 | 1 | |
Homeodomain-like | Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 | |
L,D-transpeptidase pre-catalytic domain-like | L,D-transpeptidase catalytic domain-like | 1 | 1 | |
PPK N-terminal domain-like | Phospholipase D/nuclease | 1 | 1 | |
GIY-YIG endonuclease | C-terminal UvrC-binding domain of UvrB | 1 | 1 | |
N-terminal domain of MutM-like DNA repair proteins | S13-like H2TH domain | 1 | 1 | |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Nucleotidylyl transferase | 1 | 1 | |
Galactose-binding domain-like | beta-Galactosidase/glucuronidase domain | 1 | 1 | |
Methylglyoxal synthase-like | Cytidine deaminase-like | 1 | 1 | |
Nucleotide-diphospho-sugar transferases | Trimeric LpxA-like enzymes | 1 | 1 | |
Sensory domain-like | PYP-like sensor domain (PAS domain) | 1 | 1 | |
GIY-YIG endonuclease | RuvA domain 2-like | 1 | 1 | |
YbaK/ProRS associated domain | Class II aaRS ABD-related | 1 | 1 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Sm-like ribonucleoproteins | 1 | 1 | |
PA domain | Sialidases | 1 | 1 | |
HD-domain/PDEase-like | Nucleotidyltransferase | 1 | 1 | |
Methylated DNA-protein cysteine methyltransferase domain | Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 1 | 1 | |
CRISPR-associated protein | CRISPR-associated protein | 1 | 1 | |
PurM C-terminal domain-like | PurM C-terminal domain-like | 1 | 1 | |
Nudix | "Winged helix" DNA-binding domain | 1 | 1 | |
Aminoacid dehydrogenase-like, N-terminal domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 | |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | CoaB-like | 1 | 1 | |
Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Ribosomal protein S5 domain 2-like | DNA mismatch repair protein MutL | 1 | 1 | |
PRTase-like | PRTase-like | 1 | 1 | |
Obg GTP-binding protein N-terminal domain | Obg GTP-binding protein C-terminal domain | 1 | 1 | |
CorA soluble domain-like | Magnesium transport protein CorA, transmembrane region | 1 | 1 | |
DnaJ/Hsp40 cysteine-rich domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 | |
NagB/RpiA/CoA transferase-like | D-ribose-5-phosphate isomerase (RpiA), lid domain | 1 | 1 | |
Nucleic acid-binding proteins | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
Insert subdomain of RNA polymerase alpha subunit | C-terminal domain of RNA polymerase alpha subunit | 1 | 1 | |
Nucleotide-binding domain | FAD-linked reductases, C-terminal domain | 1 | 1 | |
Galactose mutarotase-like | Glycosyl hydrolase domain | 1 | 1 | |
Tricorn protease domain 2 | alpha/beta-Hydrolases | 1 | 1 | |
RBP11-like subunits of RNA polymerase | C-terminal domain of RNA polymerase alpha subunit | 1 | 1 | |
S-adenosylmethionine synthetase | S-adenosylmethionine synthetase | 1 | 1 | |
Double Clp-N motif | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | TrkA C-terminal domain-like | 1 | 1 | |
Sigma3 and sigma4 domains of RNA polymerase sigma factors | Ribonuclease H-like | 1 | 1 | |
(Trans)glycosidases | Glycosyl hydrolase domain | 1 | 1 | |
NusB-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
DNA repair protein MutS, domain I | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
GroEL equatorial domain-like | GroEL apical domain-like | 1 | 1 | |
beta-Galactosidase/glucuronidase domain | beta-Galactosidase/glucuronidase domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 | |
DNA repair protein MutS, domain II | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | alpha/beta-Hydrolases | 1 | 1 | |
beta-Galactosidase/glucuronidase domain | Galactose mutarotase-like | 1 | 1 | |
HAMP domain-like | PYP-like sensor domain (PAS domain) | 1 | 1 | |
Sensory domain-like | HAMP domain-like | 1 | 1 | |