All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 33 | 14 | |
Homodimeric domain of signal transducing histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 32 | 5 | |
CheY-like | C-terminal effector domain of the bipartite response regulators | 22 | 2 | |
Sigma2 domain of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 18 | 3 | |
Actin-like ATPase domain | Actin-like ATPase domain | 18 | 4 | |
Homeodomain-like | Homeodomain-like | 15 | 6 | |
ABC transporter transmembrane region | P-loop containing nucleoside triphosphate hydrolases | 15 | 2 | |
Sensory domain-like | Methyl-accepting chemotaxis protein (MCP) signaling domain | 14 | 3 | |
HAMP domain-like | Homodimeric domain of signal transducing histidine kinase | 14 | 2 | |
HAMP domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 14 | 2 | |
Calcium ATPase, transduction domain A | Calcium ATPase, transmembrane domain M | 12 | 4 | |
Calcium ATPase, transduction domain A | HAD-like | 12 | 4 | |
HAD-like | Calcium ATPase, transmembrane domain M | 12 | 4 | |
P-loop containing nucleoside triphosphate hydrolases | Homeodomain-like | 11 | 8 | |
NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 10 | 4 | |
P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 9 | 7 | |
P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 8 | 6 | |
Composite domain of metallo-dependent hydrolases | Metallo-dependent hydrolases | 8 | 4 | |
"Winged helix" DNA-binding domain | Periplasmic binding protein-like II | 8 | 1 | |
"Winged helix" DNA-binding domain | PLP-dependent transferases | 7 | 1 | |
PYP-like sensor domain (PAS domain) | Homeodomain-like | 7 | 6 | |
PYP-like sensor domain (PAS domain) | P-loop containing nucleoside triphosphate hydrolases | 7 | 6 | |
cAMP-binding domain-like | "Winged helix" DNA-binding domain | 7 | 1 | |
Homeodomain-like | Probable bacterial effector-binding domain | 7 | 2 | |
Homeodomain-like | Tetracyclin repressor-like, C-terminal domain | 7 | 1 | |
Homeodomain-like | SIS domain | 7 | 1 | |
"Winged helix" DNA-binding domain | NagB/RpiA/CoA transferase-like | 6 | 1 | |
Calcium ATPase, transduction domain A | Metal cation-transporting ATPase, ATP-binding domain N | 6 | 1 | |
Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 6 | 1 | |
Metal cation-transporting ATPase, ATP-binding domain N | Calcium ATPase, transmembrane domain M | 6 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 6 | 5 | |
MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, peptide-binding domain | 6 | 4 | |
Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 6 | 6 | |
Thiamin diphosphate-binding fold (THDP-binding) | TK C-terminal domain-like | 6 | 3 | |
Translation proteins | EF-G C-terminal domain-like | 6 | 5 | |
Metal cation-transporting ATPase, ATP-binding domain N | HAD-like | 6 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 5 | 5 | |
Riboflavin synthase domain-like | Ferredoxin reductase-like, C-terminal NADP-linked domain | 5 | 2 | |
PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 5 | 4 | |
Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 5 | 2 | |
Alpha-L RNA-binding motif | Pseudouridine synthase | 5 | 1 | |
Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 5 | 1 | |
Creatinase/prolidase N-terminal domain | Creatinase/aminopeptidase | 5 | 2 | |
NAD(P)-binding Rossmann-fold domains | LDH C-terminal domain-like | 5 | 1 | |
Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 5 | 4 | |
Putative DNA-binding domain | Probable bacterial effector-binding domain | 5 | 1 | |
NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 5 | 2 | |
alpha-helical ferredoxin | Nucleotide-binding domain | 5 | 4 | |
DNA repair protein MutS, domain III | P-loop containing nucleoside triphosphate hydrolases | 5 | 4 | |
P-loop containing nucleoside triphosphate hydrolases | MOP-like | 5 | 1 | |
EF-G C-terminal domain-like | EF-G C-terminal domain-like | 5 | 4 | |
Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 5 | 3 | |
lambda repressor-like DNA-binding domains | RmlC-like cupins | 5 | 1 | |
PTS-regulatory domain, PRD | PTS-regulatory domain, PRD | 5 | 3 | |
4Fe-4S ferredoxins | Fe-only hydrogenase | 5 | 4 | |
EF-G C-terminal domain-like | Ribosomal protein S5 domain 2-like | 4 | 3 | |
Metallo-hydrolase/oxidoreductase | Flavoproteins | 4 | 1 | |
2Fe-2S ferredoxin-like | CO dehydrogenase ISP C-domain like | 4 | 2 | |
PLP-binding barrel | Alanine racemase C-terminal domain-like | 4 | 1 | |
CO dehydrogenase molybdoprotein N-domain-like | Molybdenum cofactor-binding domain | 4 | 2 | |
Sigma3 and sigma4 domains of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 4 | 1 | |
Adenine nucleotide alpha hydrolases-like | DHS-like NAD/FAD-binding domain | 4 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 4 | 3 | |
LuxS/MPP-like metallohydrolase | LuxS/MPP-like metallohydrolase | 4 | 2 | |
Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 4 | 1 | |
PurM N-terminal domain-like | PurM C-terminal domain-like | 4 | 2 | |
Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 4 | 3 | |
4Fe-4S ferredoxins | Radical SAM enzymes | 4 | 1 | |
Nucleic acid-binding proteins | Nucleic acid-binding proteins | 4 | 4 | |
P-loop containing nucleoside triphosphate hydrolases | FtsH protease domain-like | 4 | 2 | |
TPR-like | TPR-like | 4 | 4 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 4 | 3 | |
FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 4 | 3 | |
Acyl-CoA dehydrogenase NM domain-like | Acyl-CoA dehydrogenase C-terminal domain-like | 4 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 4 | 2 | |
Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 3 | 2 | |
Glucose permease domain IIB | Duplicated hybrid motif | 3 | 2 | |
Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 3 | 1 | |
tRNA-binding arm | Class II aaRS and biotin synthetases | 3 | 1 | |
PYP-like sensor domain (PAS domain) | Homodimeric domain of signal transducing histidine kinase | 3 | 2 | |
PYP-like sensor domain (PAS domain) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 3 | 2 | |
ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 3 | 3 | |
ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 3 | 3 | |
Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 3 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | ACT-like | 3 | 2 | |
"Winged helix" DNA-binding domain | GntR ligand-binding domain-like | 3 | 1 | |
Regulatory protein AraC | Homeodomain-like | 3 | 2 | |
RuvA domain 2-like | Nucleic acid-binding proteins | 3 | 3 | |
Flavoproteins | 4Fe-4S ferredoxins | 3 | 1 | |
Nqo1 FMN-binding domain-like | Nqo1 middle domain-like | 3 | 2 | |
Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 3 | 2 | |
SacY-like RNA-binding domain | PTS-regulatory domain, PRD | 3 | 1 | |
FAD-binding/transporter-associated domain-like | CO dehydrogenase flavoprotein C-terminal domain-like | 3 | 1 | |
GroES-like | NAD(P)-binding Rossmann-fold domains | 3 | 1 | |
FKBP-like | Triger factor/SurA peptide-binding domain-like | 3 | 3 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 3 | 2 | |
Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 3 | 2 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 3 | 2 | |
(Trans)glycosidases | Glycosyl hydrolase domain | 3 | 2 | |
Translation proteins | Ribosomal protein S5 domain 2-like | 3 | 2 | |
PreATP-grasp domain | Rudiment single hybrid motif | 3 | 2 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 3 | 2 | |
GAF domain-like | Homeodomain-like | 3 | 2 | |
Aldolase | AFP III-like domain | 3 | 1 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 3 | 2 | |
Penicillin binding protein dimerisation domain | beta-lactamase/transpeptidase-like | 3 | 3 | |
Nucleotide-diphospho-sugar transferases | TPR-like | 3 | 3 | |
P-loop containing nucleoside triphosphate hydrolases | Class I glutamine amidotransferase-like | 3 | 1 | |
lambda repressor-like DNA-binding domains | TPR-like | 3 | 3 | |
Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 3 | 3 | |
Carbamate kinase-like | ACT-like | 3 | 1 | |
Acyl-CoA N-acyltransferases (Nat) | Acyl-CoA N-acyltransferases (Nat) | 3 | 1 | |
ACT-like | ACT-like | 3 | 1 | |
GAF domain-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 | |
Thiolase-like | Thiolase-like | 3 | 1 | |
4Fe-4S ferredoxins | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 | |
"Winged helix" DNA-binding domain | Dimeric alpha+beta barrel | 2 | 1 | |
Nitrite/Sulfite reductase N-terminal domain-like | 4Fe-4S ferredoxins | 2 | 1 | |
TK C-terminal domain-like | 4Fe-4S ferredoxins | 2 | 1 | |
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 4Fe-4S ferredoxins | 2 | 1 | |
(Trans)glycosidases | Carbohydrate binding domain | 2 | 2 | |
CBS-domain pair | FAD-binding/transporter-associated domain-like | 2 | 1 | |
4Fe-4S ferredoxins | DHS-like NAD/FAD-binding domain | 2 | 1 | |
Nucleotide-diphospho-sugar transferases | UDP-Glycosyltransferase/glycogen phosphorylase | 2 | 2 | |
MoeA N-terminal region -like | MoeA C-terminal domain-like | 2 | 2 | |
HMA, heavy metal-associated domain | Calcium ATPase, transmembrane domain M | 2 | 2 | |
"Winged helix" DNA-binding domain | Chorismate lyase-like | 2 | 1 | |
LysM domain | LysM domain | 2 | 2 | |
MurE/MurF N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 1 | |
GreA transcript cleavage protein, N-terminal domain | FKBP-like | 2 | 1 | |
(Trans)glycosidases | Cyclophilin-like | 2 | 1 | |
HMA, heavy metal-associated domain | Calcium ATPase, transduction domain A | 2 | 2 | |
Collagen-binding domain | Collagen-binding domain | 2 | 2 | |
GAF domain-like | "Winged helix" DNA-binding domain | 2 | 2 | |
RuvA domain 2-like | BRCT domain | 2 | 2 | |
Nucleic acid-binding proteins | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 1 | |
Nucleotide cyclase | HD-domain/PDEase-like | 2 | 2 | |
SirA-like | DsrEFH-like | 2 | 2 | |
PYP-like sensor domain (PAS domain) | Nucleotide cyclase | 2 | 2 | |
Nitrite/Sulfite reductase N-terminal domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 2 | 1 | |
FAD/NAD-linked reductases, dimerisation (C-terminal) domain | Rhodanese/Cell cycle control phosphatase | 2 | 2 | |
TK C-terminal domain-like | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 2 | 1 | |
Nucleotidylyl transferase | Alpha-L RNA-binding motif | 2 | 1 | |
4Fe-4S ferredoxins | Nitrite and sulphite reductase 4Fe-4S domain-like | 2 | 1 | |
Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 2 | 1 | |
NAD(P)-linked oxidoreductase | alpha-helical ferredoxin | 2 | 1 | |
N-terminal domain of DnaB helicase | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 | |
Metalloproteases ("zincins"), catalytic domain | Clostridium neurotoxins, "coiled-coil" domain | 2 | 2 | |
Lysozyme-like | beta-lactamase/transpeptidase-like | 2 | 2 | |
Class I glutamine amidotransferase-like | LD-carboxypeptidase A C-terminal domain-like | 2 | 1 | |
Rubredoxin-like | Ferritin-like | 2 | 2 | |
Class II aaRS and biotin synthetases | SufE/NifU | 2 | 1 | |
Molybdenum cofactor biosynthesis proteins | MoeA C-terminal domain-like | 2 | 2 | |
Glucocorticoid receptor-like (DNA-binding domain) | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Fe,Mn superoxide dismutase (SOD), N-terminal domain | Fe,Mn superoxide dismutase (SOD), C-terminal domain | 2 | 1 | |
4Fe-4S ferredoxins | PYP-like sensor domain (PAS domain) | 2 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 2 | 1 | |
CheC-like | Surface presentation of antigens (SPOA) | 2 | 2 | |
PYP-like sensor domain (PAS domain) | PYP-like sensor domain (PAS domain) | 2 | 2 | |
Rhodanese/Cell cycle control phosphatase | Rhodanese/Cell cycle control phosphatase | 2 | 2 | |
DNA clamp | DNA clamp | 2 | 1 | |
alpha-helical ferredoxin | alpha-helical ferredoxin | 2 | 2 | |
Double Clp-N motif | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 | |
CorA soluble domain-like | Magnesium transport protein CorA, transmembrane region | 2 | 1 | |
MurE/MurF N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 1 | |
"Winged helix" DNA-binding domain | TrkA C-terminal domain-like | 2 | 1 | |
Clostridium neurotoxins, "coiled-coil" domain | Concanavalin A-like lectins/glucanases | 2 | 2 | |
4Fe-4S ferredoxins | Adenine nucleotide alpha hydrolases-like | 2 | 1 | |
Glutathione synthetase ATP-binding domain-like | Phosphohistidine domain | 2 | 2 | |
Formyltransferase | FMT C-terminal domain-like | 2 | 1 | |
Metalloproteases ("zincins"), catalytic domain | Concanavalin A-like lectins/glucanases | 2 | 2 | |
FAD/NAD(P)-binding domain | FAD-linked reductases, C-terminal domain | 2 | 2 | |
Methionine synthase domain | Cobalamin (vitamin B12)-binding domain | 2 | 2 | |
GIY-YIG endonuclease | C-terminal UvrC-binding domain of UvrB | 2 | 2 | |
(Trans)glycosidases | Chitinase insertion domain | 2 | 2 | |
MurCD N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 2 | 1 | |
CBS-domain pair | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
L30e-like | alpha/beta knot | 2 | 1 | |
GAF domain-like | PYP-like sensor domain (PAS domain) | 2 | 1 | |
FAD/NAD(P)-binding domain | HI0933 insert domain-like | 2 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | 4Fe-4S ferredoxins | 2 | 1 | |
"Winged helix" DNA-binding domain | "Winged helix" DNA-binding domain | 2 | 2 | |
lambda repressor-like DNA-binding domains | Periplasmic binding protein-like I | 2 | 1 | |
FAD/NAD(P)-binding domain | Rhodanese/Cell cycle control phosphatase | 2 | 2 | |
Nucleotide-binding domain | Nucleotide-binding domain | 2 | 2 | |
NAD(P)-binding Rossmann-fold domains | TrkA C-terminal domain-like | 2 | 2 | |
ThrRS/AlaRS common domain | Class II aaRS and biotin synthetases | 2 | 2 | |
HMA, heavy metal-associated domain | HAD-like | 2 | 2 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Type II DNA topoisomerase | 2 | 1 | |
MetI-like | Periplasmic binding protein-like II | 2 | 1 | |
Translation proteins SH3-like domain | Nucleic acid-binding proteins | 2 | 2 | |
"Winged helix" DNA-binding domain | PTS-regulatory domain, PRD | 2 | 2 | |
MoeA N-terminal region -like | Molybdenum cofactor biosynthesis proteins | 2 | 2 | |
Type II DNA topoisomerase | GyrA/ParC C-terminal domain-like | 2 | 2 | |
MgtE N-terminal domain-like | CBS-domain pair | 2 | 2 | |
MurCD N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 1 | |
Nucleic acid-binding proteins | HD-domain/PDEase-like | 2 | 1 | |
Fe-only hydrogenase | PYP-like sensor domain (PAS domain) | 2 | 1 | |
Nicotinate/Quinolinate PRTase N-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 2 | 1 | |
Ribosomal protein S5 domain 2-like | Type II DNA topoisomerase | 2 | 1 | |
Ribonuclease H-like | Nucleic acid-binding proteins | 2 | 2 | |
Ribonuclease H-like | RuvA domain 2-like | 1 | 1 | |
Chemotaxis receptor methyltransferase CheR, N-terminal domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
YrdC/RibB | RibA-like | 1 | 1 | |
ParB/Sulfiredoxin | KorB DNA-binding domain-like | 1 | 1 | |
2Fe-2S ferredoxin-like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 | |
DHS-like NAD/FAD-binding domain | Rubredoxin-like | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
"Winged helix" DNA-binding domain | PRTase-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | HRDC-like | 1 | 1 | |
Coiled-coil domain of nucleotide exchange factor GrpE | Head domain of nucleotide exchange factor GrpE | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | MurD-like peptide ligases, catalytic domain | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Pyrimidine nucleoside phosphorylase C-terminal domain | 1 | 1 | |
FAD/NAD-linked reductases, dimerisation (C-terminal) domain | SirA-like | 1 | 1 | |
Translation proteins | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 | |
NusB-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
PYP-like sensor domain (PAS domain) | HD-domain/PDEase-like | 1 | 1 | |
Acyl-CoA dehydrogenase NM domain-like | DHS-like NAD/FAD-binding domain | 1 | 1 | |
DNA repair protein MutS, domain II | DNA repair protein MutS, domain III | 1 | 1 | |
Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 1 | 1 | |
E set domains | E set domains | 1 | 1 | |
YojJ-like | RuvA domain 2-like | 1 | 1 | |
Aconitase iron-sulfur domain | LeuD/IlvD-like | 1 | 1 | |
PDZ domain-like | ClpP/crotonase | 1 | 1 | |
Homeodomain-like | (Trans)glycosidases | 1 | 1 | |
Obg GTP-binding protein N-terminal domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Tex N-terminal region-like | RuvA domain 2-like | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | HSP90 C-terminal domain | 1 | 1 | |
Acyl-CoA dehydrogenase NM domain-like | Rubredoxin-like | 1 | 1 | |
FabD/lysophospholipase-like | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal UvrC-binding domain of UvrB | 1 | 1 | |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | Alkaline phosphatase-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Helical scaffold and wing domains of SecA | 1 | 1 | |
Phospholipase D/nuclease | Phospholipase D/nuclease | 1 | 1 | |
Aldolase | post-HMGL domain-like | 1 | 1 | |
FAD/NAD(P)-binding domain | ISP domain | 1 | 1 | |
LysM domain | (Trans)glycosidases | 1 | 1 | |
PIN domain-like | Ribonuclease H-like | 1 | 1 | |
DNA repair protein MutS, domain I | DNA repair protein MutS, domain III | 1 | 1 | |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 1 | 1 | |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | ACT-like | 1 | 1 | |
RmlC-like cupins | (Trans)glycosidases | 1 | 1 | |
Zinc beta-ribbon | DNA primase core | 1 | 1 | |
Nucleotidylyl transferase | Nucleic acid-binding proteins | 1 | 1 | |
Aspartate/glutamate racemase | Aspartate/glutamate racemase | 1 | 1 | |
F1F0 ATP synthase subunit C | F1F0 ATP synthase subunit C | 1 | 1 | |
Periplasmic binding protein-like II | Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | 1 | |
Molybdenum cofactor biosynthesis proteins | CinA-like | 1 | 1 | |
Ribonuclease H-like | BRCT domain | 1 | 1 | |
"Winged helix" DNA-binding domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
CO dehydrogenase ISP C-domain like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 | |
RmlC-like cupins | Glycosyl hydrolase domain | 1 | 1 | |
Epsilon subunit of F1F0-ATP synthase N-terminal domain | Epsilon subunit of F1F0-ATP synthase C-terminal domain | 1 | 1 | |
Dihydropteroate synthetase-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 1 | 1 | |
FMN-linked oxidoreductases | FAD/NAD(P)-binding domain | 1 | 1 | |
Chitinase insertion domain | Carbohydrate-binding domain | 1 | 1 | |
Phosphoenolpyruvate/pyruvate domain | Homeodomain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Pre-protein crosslinking domain of SecA | 1 | 1 | |
Thioredoxin-like | Nqo1 middle domain-like | 1 | 1 | |
HPr-like | PYP-like sensor domain (PAS domain) | 1 | 1 | |
Cysteine proteinases | PGBD-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | PTS system fructose IIA component-like | 1 | 1 | |
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain | Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 1 | 1 | |
PGBD-like | LysM domain | 1 | 1 | |
Aldolase | Single hybrid motif | 1 | 1 | |
Folate-binding domain | Aminomethyltransferase beta-barrel domain | 1 | 1 | |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | Nucleic acid-binding proteins | 1 | 1 | |
post-HMGL domain-like | Single hybrid motif | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 | |
GroEL equatorial domain-like | GroEL apical domain-like | 1 | 1 | |
"Winged helix" DNA-binding domain | PTS system IIB component-like | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | RuvA domain 2-like | 1 | 1 | |
Sec-C motif | Creatinase/aminopeptidase | 1 | 1 | |
Thioredoxin-like | 4Fe-4S ferredoxins | 1 | 1 | |
(Trans)glycosidases | E set domains | 1 | 1 | |
PheT/TilS domain | Putative DNA-binding domain | 1 | 1 | |
TrpR-like | TrpR-like | 1 | 1 | |
CbiG N-terminal domain-like | CobE/GbiG C-terminal domain-like | 1 | 1 | |
Putative DNA-binding domain | Anticodon-binding domain of PheRS | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | LexA/Signal peptidase | 1 | 1 | |
CheY-binding domain of CheA | CheW-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Methylglyoxal synthase-like | 1 | 1 | |
Nucleotide-diphospho-sugar transferases | Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain | 1 | 1 | |
Nqo1 FMN-binding domain-like | Nqo1C-terminal domain-like | 1 | 1 | |
Putative DNA-binding domain | Antibiotic binding domain of TipA-like multidrug resistance regulators | 1 | 1 | |
Rho N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Nqo1 FMN-binding domain-like | alpha-helical ferredoxin | 1 | 1 | |
L9 N-domain-like | Ribosomal protein L9 C-domain | 1 | 1 | |
Kelch motif | Zn-dependent exopeptidases | 1 | 1 | |
PDZ domain-like | Radical SAM enzymes | 1 | 1 | |
FAD-binding/transporter-associated domain-like | FAD-linked oxidases, C-terminal domain | 1 | 1 | |
Trypsin-like serine proteases | PDZ domain-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 | |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 1 | 1 | |
PreATP-grasp domain | Single hybrid motif | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 1 | 1 | |
Dihydropteroate synthetase-like | Methionine synthase domain | 1 | 1 | |
Class II aaRS and biotin synthetases | C-terminal domain of transcriptional repressors | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 | |
Rhodanese/Cell cycle control phosphatase | DsrEFH-like | 1 | 1 | |
CO dehydrogenase ISP C-domain like | Molybdenum cofactor-binding domain | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TGS-like | 1 | 1 | |
PK C-terminal domain-like | Phosphohistidine domain | 1 | 1 | |
TGS-like | Class II aaRS ABD-related | 1 | 1 | |
Diaminopimelate epimerase-like | Diaminopimelate epimerase-like | 1 | 1 | |
DnaJ/Hsp40 cysteine-rich domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Ribonuclease PH domain 2-like | 1 | 1 | |
MoeA C-terminal domain-like | Periplasmic binding protein-like II | 1 | 1 | |
LysM domain | PR-1-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 1 | 1 | |
PIN domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
CheY-binding domain of CheA | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
L,D-transpeptidase pre-catalytic domain-like | L,D-transpeptidase catalytic domain-like | 1 | 1 | |
RmlC-like cupins | Homeodomain-like | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
Trigger factor ribosome-binding domain | FKBP-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
L,D-transpeptidase catalytic domain-like | PGBD-like | 1 | 1 | |
PheT/TilS domain | Class II aaRS and biotin synthetases | 1 | 1 | |
Translation proteins | "Winged helix" DNA-binding domain | 1 | 1 | |
YjeF N-terminal domain-like | Ribokinase-like | 1 | 1 | |
LysM domain | Zn-dependent exopeptidases | 1 | 1 | |
Translation initiation factor IF3, N-terminal domain | Translation initiation factor IF3, C-terminal domain | 1 | 1 | |
Glutamine synthetase/guanido kinase | GatB/YqeY motif | 1 | 1 | |
"Winged helix" DNA-binding domain | Phoshotransferase/anion transport protein | 1 | 1 | |
"Winged helix" DNA-binding domain | HRDC-like | 1 | 1 | |
PTS system fructose IIA component-like | PTS IIb component | 1 | 1 | |
Thiamin pyrophosphokinase, catalytic domain | Thiamin pyrophosphokinase, substrate-binding domain | 1 | 1 | |
Adenine nucleotide alpha hydrolases-like | MesJ substrate recognition domain-like | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | tRNA-binding arm | 1 | 1 | |
FliG | FliG | 1 | 1 | |
HMA, heavy metal-associated domain | HMA, heavy metal-associated domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Smc hinge domain | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | CheW-like | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
PTS system IIB component-like | Phoshotransferase/anion transport protein | 1 | 1 | |
L domain-like | L domain-like | 1 | 1 | |
PGBD-like | Zn-dependent exopeptidases | 1 | 1 | |
GyrA/ParC C-terminal domain-like | GyrA/ParC C-terminal domain-like | 1 | 1 | |
R1 subunit of ribonucleotide reductase, N-terminal domain | PFL-like glycyl radical enzymes | 1 | 1 | |
lambda repressor-like DNA-binding domains | LexA/Signal peptidase | 1 | 1 | |
PK beta-barrel domain-like | PK C-terminal domain-like | 1 | 1 | |
ARM repeat | Nucleotidylyl transferase | 1 | 1 | |
RuvA domain 2-like | RuvA domain 2-like | 1 | 1 | |
HD-domain/PDEase-like | Nucleotidylyl transferase | 1 | 1 | |
Nucleotide cyclase | EAL domain-like | 1 | 1 | |
"Winged helix" DNA-binding domain | PTS system fructose IIA component-like | 1 | 1 | |
Class II aaRS ABD-related | C-terminal domain of ProRS | 1 | 1 | |
Zinc beta-ribbon | Zinc beta-ribbon | 1 | 1 | |
DNA repair protein MutS, domain I | DNA repair protein MutS, domain II | 1 | 1 | |
ThrRS/AlaRS common domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
PTS-regulatory domain, PRD | PTS system fructose IIA component-like | 1 | 1 | |
YbaK/ProRS associated domain | Class II aaRS ABD-related | 1 | 1 | |
Serine metabolism enzymes domain | ACT-like | 1 | 1 | |
Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Tex N-terminal region-like | Nucleic acid-binding proteins | 1 | 1 | |
beta-lactamase/transpeptidase-like | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
HprK N-terminal domain-like | DHH phosphoesterases | 1 | 1 | |
Cysteine proteinases | DPP6 N-terminal domain-like | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
Aldehyde ferredoxin oxidoreductase, N-terminal domain | Aldehyde ferredoxin oxidoreductase, C-terminal domains | 1 | 1 | |
PUA domain-like | alpha/beta knot | 1 | 1 | |
Translation proteins | PRC-barrel domain | 1 | 1 | |
Single hybrid motif | CoA-dependent acyltransferases | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Nucleic acid-binding proteins | 1 | 1 | |
Tetrapyrrole methylase | all-alpha NTP pyrophosphatases | 1 | 1 | |
PreATP-grasp domain | post-HMGL domain-like | 1 | 1 | |
Putative DNA-binding domain | Putative DNA-binding domain | 1 | 1 | |
PKD domain | Collagen-binding domain | 1 | 1 | |
Tex N-terminal region-like | Ribonuclease H-like | 1 | 1 | |
Nucleic acid-binding proteins | PheT/TilS domain | 1 | 1 | |
ACT-like | PYP-like sensor domain (PAS domain) | 1 | 1 | |
Nqo1C-terminal domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
"Winged helix" DNA-binding domain | Ribokinase-like | 1 | 1 | |
HD-domain/PDEase-like | TGS-like | 1 | 1 | |
Translation proteins | Translation proteins | 1 | 1 | |
GroEL-intermediate domain like | GroEL apical domain-like | 1 | 1 | |
RuvA domain 2-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Ribonuclease H-like | DNA/RNA polymerases | 1 | 1 | |
Nqo1 middle domain-like | Nqo1C-terminal domain-like | 1 | 1 | |
Penicillin binding protein dimerisation domain | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
Thioesterase/thiol ester dehydrase-isomerase | Thioesterase/thiol ester dehydrase-isomerase | 1 | 1 | |
Rudiment single hybrid motif | post-HMGL domain-like | 1 | 1 | |
Translation proteins | ThrRS/AlaRS common domain | 1 | 1 | |
HprK N-terminal domain-like | PEP carboxykinase-like | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | Translation proteins | 1 | 1 | |
Adenine nucleotide alpha hydrolases-like | PheT/TilS domain | 1 | 1 | |
Nucleotide-diphospho-sugar transferases | Nucleotide-diphospho-sugar transferases | 1 | 1 | |
PheT/TilS domain | Anticodon-binding domain of PheRS | 1 | 1 | |
"Winged helix" DNA-binding domain | DnaD domain-like | 1 | 1 | |
RuvA domain 2-like | JAB1/MPN domain | 1 | 1 | |
dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Sm-like ribonucleoproteins | 1 | 1 | |
all-alpha NTP pyrophosphatases | all-alpha NTP pyrophosphatases | 1 | 1 | |
Nucleotide-diphospho-sugar transferases | Trimeric LpxA-like enzymes | 1 | 1 | |
CBS-domain pair | DHH phosphoesterases | 1 | 1 | |
FMN-linked oxidoreductases | 4Fe-4S ferredoxins | 1 | 1 | |
HSP40/DnaJ peptide-binding domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
EspE N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Elongation factor Ts (EF-Ts), dimerisation domain | Elongation factor Ts (EF-Ts), dimerisation domain | 1 | 1 | |
ValRS/IleRS/LeuRS editing domain | tRNA-binding arm | 1 | 1 | |
Adenine nucleotide alpha hydrolases-like | Argininosuccinate synthetase, C-terminal domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TrpR-like | 1 | 1 | |
Ribonuclease PH domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
Ribosomal protein L6 | Ribosomal protein L6 | 1 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 | |
Acylphosphatase/BLUF domain-like | YrdC/RibB | 1 | 1 | |
Ribosomal L11/L12e N-terminal domain | Ribosomal protein L11, C-terminal domain | 1 | 1 | |
PIN domain-like | DNA/RNA polymerases | 1 | 1 | |
RNase III domain-like | dsRNA-binding domain-like | 1 | 1 | |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Restriction endonuclease-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | CheW-like | 1 | 1 | |
Lysozyme-like | Cysteine proteinases | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | Homodimeric domain of signal transducing histidine kinase | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
(Trans)glycosidases | Fibronectin type III | 1 | 1 | |
Composite domain of metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 1 | 1 | |
Nucleotidylyl transferase | Riboflavin kinase-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Aldolase | 1 | 1 | |
Molybdenum cofactor biosynthesis proteins | Periplasmic binding protein-like II | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Hypothetical protein YjiA, C-terminal domain | 1 | 1 | |
Eukaryotic type KH-domain (KH-domain type I) | Nucleic acid-binding proteins | 1 | 1 | |
Nucleotide-binding domain | FAD-linked reductases, C-terminal domain | 1 | 1 | |
PLP-dependent transferases | Ornithine decarboxylase C-terminal domain | 1 | 1 | |
F1F0 ATP synthase subunit B, membrane domain | V-type ATPase subunit E-like | 1 | 1 | |
Thioredoxin-like | Nqo1 FMN-binding domain-like | 1 | 1 | |
HAMP domain-like | PYP-like sensor domain (PAS domain) | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | Putative methyltransferase TM0872, insert domain | 1 | 1 | |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | "Winged helix" DNA-binding domain | 1 | 1 | |
TGS-like | ACT-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TRCF domain-like | 1 | 1 | |
FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | 1 | |
S-adenosylmethionine synthetase | S-adenosylmethionine synthetase | 1 | 1 | |
PreATP-grasp domain | PreATP-grasp domain | 1 | 1 | |
Thioredoxin-like | Six-hairpin glycosidases | 1 | 1 | |
Chitinase insertion domain | E set domains | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
Obg GTP-binding protein N-terminal domain | Obg GTP-binding protein C-terminal domain | 1 | 1 | |
PurM C-terminal domain-like | PurM C-terminal domain-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Single hybrid motif | 1 | 1 | |
Transcription factor NusA, N-terminal domain | Nucleic acid-binding proteins | 1 | 1 | |
Class II aaRS and biotin synthetases | Translation proteins | 1 | 1 | |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | Phosphohistidine domain | 1 | 1 | |
Carbohydrate binding domain | Carbohydrate binding domain | 1 | 1 | |
Nucleotidyltransferase | ACT-like | 1 | 1 | |
CBS-domain pair | PYP-like sensor domain (PAS domain) | 1 | 1 | |
Ribosomal protein S5 domain 2-like | HSP90 C-terminal domain | 1 | 1 | |
Homeodomain-like | Glycosyl hydrolase domain | 1 | 1 | |
PurM N-terminal domain-like | Class I glutamine amidotransferase-like | 1 | 1 | |
"Winged helix" DNA-binding domain | CBS-domain pair | 1 | 1 | |
PurM N-terminal domain-like | PurM N-terminal domain-like | 1 | 1 | |
N-utilization substance G protein NusG, N-terminal domain | Translation proteins SH3-like domain | 1 | 1 | |
CarD-like | TRCF domain-like | 1 | 1 | |
PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
Chaperone J-domain | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 | |
AbrB/MazE/MraZ-like | GAF domain-like | 1 | 1 | |
4'-phosphopantetheinyl transferase | 4'-phosphopantetheinyl transferase | 1 | 1 | |
Cysteine proteinases | Cysteine proteinases | 1 | 1 | |
Creatinase/prolidase N-terminal domain | Creatinase/prolidase N-terminal domain | 1 | 1 | |
Tropomyosin | Cysteine proteinases | 1 | 1 | |
Zinc beta-ribbon | N-terminal domain of DnaB helicase | 1 | 1 | |
DNA repair protein MutS, domain II | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
CheY-like | Methylesterase CheB, C-terminal domain | 1 | 1 | |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | ACT-like | 1 | 1 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | DNA methylase specificity domain | 1 | 1 | |
DnaK suppressor protein DksA, alpha-hairpin domain | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 | |
Ribosomal protein L7/12, oligomerisation (N-terminal) domain | ClpS-like | 1 | 1 | |
Ribonuclease PH domain 2-like | Ribonuclease PH domain 2-like | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Concanavalin A-like lectins/glucanases | STI-like | 1 | 1 | |
Cell wall binding repeat | Cell wall binding repeat | 1 | 1 | |
Ribosomal protein S5 domain 2-like | DNA mismatch repair protein MutL | 1 | 1 | |
Carbamoyl phosphate synthetase, large subunit connection domain | Methylglyoxal synthase-like | 1 | 1 | |
DNA/RNA polymerases | Lesion bypass DNA polymerase (Y-family), little finger domain | 1 | 1 | |
DNA methylase specificity domain | DNA methylase specificity domain | 1 | 1 | |
RuvA domain 2-like | DNA helicase RuvA subunit, C-terminal domain | 1 | 1 | |
YWTD domain | YWTD domain | 1 | 1 | |
"Winged helix" DNA-binding domain | Putative transcriptional regulator TM1602, C-terminal domain | 1 | 1 | |
Class I glutamine amidotransferase-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
Rubredoxin-like | Superoxide reductase-like | 1 | 1 | |
Nucleic acid-binding proteins | GAD domain-like | 1 | 1 | |
Homodimeric domain of signal transducing histidine kinase | CheW-like | 1 | 1 | |
PTS-regulatory domain, PRD | PTS system IIB component-like | 1 | 1 | |
Thioredoxin-like | NHL repeat | 1 | 1 | |
Rho N-terminal domain-like | Nucleic acid-binding proteins | 1 | 1 | |
IlvD/EDD N-terminal domain-like | LeuD/IlvD-like | 1 | 1 | |
Rudiment single hybrid motif | Aldolase | 1 | 1 | |
2Fe-2S ferredoxin-like | 4Fe-4S ferredoxins | 1 | 1 | |
HD-domain/PDEase-like | ACT-like | 1 | 1 | |
Cytidine deaminase-like | Dihydrofolate reductase-like | 1 | 1 | |
Ribonuclease PH domain 2-like | Nucleic acid-binding proteins | 1 | 1 | |
Sm-like ribonucleoproteins | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 1 | 1 | |
Pre-protein crosslinking domain of SecA | Helical scaffold and wing domains of SecA | 1 | 1 | |
FMN-linked oxidoreductases | alpha-helical ferredoxin | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | MurD-like peptide ligases, peptide-binding domain | 1 | 1 | |
Thioredoxin-like | Nqo1C-terminal domain-like | 1 | 1 | |
PUA domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Nucleic acid-binding proteins | Putative DNA-binding domain | 1 | 1 | |
Nucleic acid-binding proteins | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 | |
DNA/RNA polymerases | HD-domain/PDEase-like | 1 | 1 | |
Nqo1 FMN-binding domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
"Winged helix" DNA-binding domain | C-terminal domain of transcriptional repressors | 1 | 1 | |
CBS-domain pair | Homeodomain-like | 1 | 1 | |
Zinc beta-ribbon | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Fucose-specific lectin | Fucose-specific lectin | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 | |
TGS-like | ThrRS/AlaRS common domain | 1 | 1 | |
DAK1/DegV-like | DhaL-like | 1 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 | |
Methyl-accepting chemotaxis protein (MCP) signaling domain | Periplasmic binding protein-like II | 1 | 1 | |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | CoA-dependent acyltransferases | 1 | 1 | |
PK beta-barrel domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
EAL domain-like | HD-domain/PDEase-like | 1 | 1 | |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | CoaB-like | 1 | 1 | |
6-phosphogluconate dehydrogenase C-terminal domain-like | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 1 | 1 | |
Putative DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
Acyl-CoA dehydrogenase C-terminal domain-like | Rubredoxin-like | 1 | 1 | |
Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 | |
TrmE connector domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
HD-domain/PDEase-like | ARM repeat | 1 | 1 | |
HPr-like | Homeodomain-like | 1 | 1 | |
Single hybrid motif | Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | SMR domain-like | 1 | 1 | |
YhbC-like, N-terminal domain | YhbC-like, C-terminal domain | 1 | 1 | |
Rhodanese/Cell cycle control phosphatase | SirA-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | post-HMGL domain-like | 1 | 1 | |
Sporulation response regulatory protein Spo0B | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
CBS-domain pair | MgtE membrane domain-like | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 | |
Class II aaRS and biotin synthetases | Anticodon-binding domain of PheRS | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | CheY-binding domain of CheA | 1 | 1 | |
C-terminal UvrC-binding domain of UvrB | RuvA domain 2-like | 1 | 1 | |
ALDH-like | Dehydroquinate synthase-like | 1 | 1 | |
HprK N-terminal domain-like | CBS-domain pair | 1 | 1 | |
Hsp33 domain | HSP33 redox switch-like | 1 | 1 | |
Alpha-L RNA-binding motif | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
Pectin lyase-like | Invasin/intimin cell-adhesion fragments | 1 | 1 | |
CcmK-like | CcmK-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
"Winged helix" DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 | |
HPr-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 1 | 1 | |
PUA domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Galactose mutarotase-like | Six-hairpin glycosidases | 1 | 1 | |
Phospholipase D/nuclease | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Galactose mutarotase-like | Galactose mutarotase-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | ACT-like | 1 | 1 | |
MetI-like | MetI-like | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | BRCT domain | 1 | 1 | |
FAD/NAD-linked reductases, dimerisation (C-terminal) domain | DsrEFH-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Iron-dependent repressor protein, dimerization domain | 1 | 1 | |
Nucleic acid-binding proteins | Anticodon-binding domain of PheRS | 1 | 1 | |
Nucleic acid-binding proteins | DNA helicase RuvA subunit, C-terminal domain | 1 | 1 | |
Chaperone J-domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
Sensory domain-like | Nucleotide cyclase | 1 | 1 | |
Acetyl-CoA synthetase-like | ACP-like | 1 | 1 | |
GroEL equatorial domain-like | GroEL-intermediate domain like | 1 | 1 | |
Bacillus cereus metalloprotein-like | Bacillus cereus metalloprotein-like | 1 | 1 | |
DnaD domain-like | DnaD domain-like | 1 | 1 | |
Protein kinase-like (PK-like) | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
Homocysteine S-methyltransferase | Methionine synthase domain | 1 | 1 | |
PRC-barrel domain | PRC-barrel domain | 1 | 1 | |
2Fe-2S ferredoxin-like | Molybdenum cofactor-binding domain | 1 | 1 | |
Penicillin-binding protein 2x (pbp-2x), c-terminal domain | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 | |
PurM C-terminal domain-like | Class I glutamine amidotransferase-like | 1 | 1 | |
CheY-like | Histidine-containing phosphotransfer domain, HPT domain | 1 | 1 | |
Nucleotidyltransferase | Poly A polymerase C-terminal region-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Obg GTP-binding protein C-terminal domain | 1 | 1 | |
Trigger factor ribosome-binding domain | Triger factor/SurA peptide-binding domain-like | 1 | 1 | |
Cobalamin (vitamin B12)-binding domain | Radical SAM enzymes | 1 | 1 | |
CheW-like | CheY-like | 1 | 1 | |
UBA-like | Elongation factor Ts (EF-Ts), dimerisation domain | 1 | 1 | |
(Trans)glycosidases | Carbohydrate-binding domain | 1 | 1 | |
Prokaryotic type I DNA topoisomerase | Zinc beta-ribbon | 1 | 1 | |
2Fe-2S ferredoxin-like | Fe-only hydrogenase | 1 | 1 | |
PK beta-barrel domain-like | Phosphohistidine domain | 1 | 1 | |
Fibronectin type III | Carbohydrate binding domain | 1 | 1 | |
Transcription factor NusA, N-terminal domain | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
Riboflavin synthase domain-like | Riboflavin synthase domain-like | 1 | 1 | |
Eukaryotic type KH-domain (KH-domain type I) | HD-domain/PDEase-like | 1 | 1 | |
ACT-like | Homeodomain-like | 1 | 1 | |
Homocysteine S-methyltransferase | Dihydropteroate synthetase-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 1 | 1 | |
GIY-YIG endonuclease | RuvA domain 2-like | 1 | 1 | |
FAD/NAD(P)-binding domain | SirA-like | 1 | 1 | |
Dihydropteroate synthetase-like | Cobalamin (vitamin B12)-binding domain | 1 | 1 | |
MgtE N-terminal domain-like | MgtE membrane domain-like | 1 | 1 | |
Methylated DNA-protein cysteine methyltransferase domain | Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 1 | 1 | |
Clostridium neurotoxins, "coiled-coil" domain | STI-like | 1 | 1 | |
TGS-like | Class II aaRS and biotin synthetases | 1 | 1 | |
Carbon-nitrogen hydrolase | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
RBP11-like subunits of RNA polymerase | C-terminal domain of RNA polymerase alpha subunit | 1 | 1 | |
5' to 3' exonuclease, C-terminal subdomain | DNA/RNA polymerases | 1 | 1 | |
Tetrapyrrole methylase | HemD-like | 1 | 1 | |
Ribonuclease PH domain 2-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 | |
5' to 3' exonuclease, C-terminal subdomain | Ribonuclease H-like | 1 | 1 | |
Phosphoenolpyruvate/pyruvate domain | PK C-terminal domain-like | 1 | 1 | |
Class II aaRS and biotin synthetases | GAD domain-like | 1 | 1 | |
DNA repair protein MutS, domain III | SMR domain-like | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | DNA mismatch repair protein MutL | 1 | 1 | |
Ligand-binding domain in the NO signalling and Golgi transport | Methyl-accepting chemotaxis protein (MCP) signaling domain | 1 | 1 | |
MesJ substrate recognition domain-like | PheT/TilS domain | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | Pyrimidine nucleoside phosphorylase C-terminal domain | 1 | 1 | |
FMN-linked oxidoreductases | Nucleotide-binding domain | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 1 | 1 | |
DNA primase core | N-terminal domain of DnaB helicase | 1 | 1 | |
CheY-like | CheC-like | 1 | 1 | |
Acyl-CoA dehydrogenase C-terminal domain-like | DHS-like NAD/FAD-binding domain | 1 | 1 | |
DNA repair protein MutS, domain I | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | PTS-regulatory domain, PRD | 1 | 1 | |
Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 1 | 1 | |
HD-domain/PDEase-like | Nucleotidyltransferase | 1 | 1 | |
Insert subdomain of RNA polymerase alpha subunit | C-terminal domain of RNA polymerase alpha subunit | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Nucleotidylyl transferase | 1 | 1 | |
Carboxypeptidase regulatory domain-like | PHP domain-like | 1 | 1 | |
Acylphosphatase/BLUF domain-like | Actin-like ATPase domain | 1 | 1 | |
Enolase N-terminal domain-like | Enolase C-terminal domain-like | 1 | 1 | |
Homocysteine S-methyltransferase | Cobalamin (vitamin B12)-binding domain | 1 | 1 | |
FAD/NAD(P)-binding domain | DsrEFH-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Ribonuclease H-like | 1 | 1 | |
Metalloproteases ("zincins"), catalytic domain | STI-like | 1 | 1 | |
ThrRS/AlaRS common domain | Class II aaRS ABD-related | 1 | 1 | |
CheY-binding domain of CheA | Homodimeric domain of signal transducing histidine kinase | 1 | 1 | |
N-terminal domain of the delta subunit of the F1F0-ATP synthase | V-type ATPase subunit E-like | 1 | 1 | |
Nucleic acid-binding proteins | BRCT domain | 1 | 1 | |
CheY-like | CheY-like | 1 | 1 | |
Rudiment single hybrid motif | Single hybrid motif | 1 | 1 | |
TPR-like | SGNH hydrolase | 1 | 1 | |
(Trans)glycosidases | PGBD-like | 1 | 1 | |
CBS-domain pair | Inosine monophosphate dehydrogenase (IMPDH) | 1 | 1 | |
TATA-box binding protein-like | DNA-glycosylase | 1 | 1 | |
TSP type-3 repeat | alpha/beta-Hydrolases | 1 | 1 | |
Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 | |
Nucleotidylyl transferase | tRNA-binding arm | 1 | 1 | |
MoeA N-terminal region -like | Periplasmic binding protein-like II | 1 | 1 | |
CPE0013-like | Formate dehydrogenase/DMSO reductase, domains 1-3 | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | CarD-like | 1 | 1 | |
4Fe-4S ferredoxins | Nucleotide-binding domain | 1 | 1 | |
GAF domain-like | Nucleotide cyclase | 1 | 1 | |
PTS-regulatory domain, PRD | Phoshotransferase/anion transport protein | 1 | 1 | |
TrkA C-terminal domain-like | TrkA C-terminal domain-like | 1 | 1 | |
PreATP-grasp domain | Aldolase | 1 | 1 | |
HD-domain/PDEase-like | HD-domain/PDEase-like | 1 | 1 | |
PreATP-grasp domain | Methylglyoxal synthase-like | 1 | 1 | |
4Fe-4S ferredoxins | alpha-helical ferredoxin | 1 | 1 | |
PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 | |
"Winged helix" DNA-binding domain | C-terminal domain of arginine repressor | 1 | 1 | |
FAD-binding/transporter-associated domain-like | Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 1 | 1 | |
Chaperone J-domain | TPR-like | 1 | 1 | |
CBS-domain pair | Nucleotide-diphospho-sugar transferases | 1 | 1 | |
Nucleotidyltransferase | TGS-like | 1 | 1 | |
Nqo1 middle domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
YrdC/RibB | Actin-like ATPase domain | 1 | 1 | |
Methylglyoxal synthase-like | Cytidine deaminase-like | 1 | 1 | |
"Winged helix" DNA-binding domain | LexA/Signal peptidase | 1 | 1 | |
Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | RecA protein, C-terminal domain | 1 | 1 | |
Class II aaRS and biotin synthetases | C-terminal domain of ProRS | 1 | 1 | |
Class II aaRS and biotin synthetases | YbaK/ProRS associated domain | 1 | 1 | |
L domain-like | Tricorn protease N-terminal domain | 1 | 1 | |