All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
| Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
| Ribonuclease H-like | DNA/RNA polymerases | 534 | 79 |  |
| L domain-like | Protein kinase-like (PK-like) | 299 | 73 |  |
| P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 188 | 77 |  |
| Retrovirus zinc finger-like domains | Ribonuclease H-like | 165 | 32 |  |
| Acid proteases | DNA/RNA polymerases | 156 | 37 |  |
| RNA-binding domain, RBD | RNA-binding domain, RBD | 118 | 36 |  |
| L domain-like | L domain-like | 110 | 61 |  |
| RNI-like | L domain-like | 107 | 53 |  |
| RNI-like | Protein kinase-like (PK-like) | 89 | 36 |  |
| Actin-like ATPase domain | Actin-like ATPase domain | 86 | 32 |  |
| Retrovirus zinc finger-like domains | DNA/RNA polymerases | 86 | 27 |  |
| RING/U-box | ARM repeat | 81 | 17 |  |
| P-loop containing nucleoside triphosphate hydrolases | L domain-like | 78 | 25 |  |
| Ribonuclease H-like | Ribonuclease H-like | 72 | 35 |  |
| HAD-like | Calcium ATPase, transmembrane domain M | 71 | 20 |  |
| DNA/RNA polymerases | DNA/RNA polymerases | 69 | 29 |  |
| Calcium ATPase, transduction domain A | Calcium ATPase, transmembrane domain M | 69 | 18 |  |
| Calcium ATPase, transduction domain A | HAD-like | 67 | 17 |  |
| DNA/RNA polymerases | Chromo domain-like | 66 | 21 |  |
| TPR-like | TPR-like | 64 | 29 |  |
| ARM repeat | ARM repeat | 61 | 32 |  |
| F-box domain | RNI-like | 60 | 20 |  |
| Thiolase-like | Thiolase-like | 58 | 7 |  |
| Protein kinase-like (PK-like) | EF-hand | 54 | 8 |  |
| Acid proteases | Ribonuclease H-like | 53 | 22 |  |
| Cyclin-like | Cyclin-like | 53 | 10 |  |
| Cupredoxins | Cupredoxins | 53 | 8 |  |
| CRAL/TRIO N-terminal domain | CRAL/TRIO domain | 53 | 18 |  |
| Thioredoxin-like | GST C-terminal domain-like | 53 | 12 |  |
| Barwin-like endoglucanases | PHL pollen allergen | 47 | 5 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | 47 | 20 |  |
| Protein kinase-like (PK-like) | alpha-D-mannose-specific plant lectins | 47 | 13 |  |
| RNI-like | RNI-like | 44 | 25 |  |
| ABC transporter transmembrane region | P-loop containing nucleoside triphosphate hydrolases | 43 | 17 |  |
| F-box domain | Kelch motif | 43 | 9 |  |
| FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | 43 | 12 |  |
| Metal cation-transporting ATPase, ATP-binding domain N | HAD-like | 43 | 13 |  |
| Homeodomain-like | Homeodomain-like | 43 | 17 |  |
| Calcium ATPase, transmembrane domain M | Metal cation-transporting ATPase, ATP-binding domain N | 42 | 12 |  |
| Plant invertase/pectin methylesterase inhibitor | Pectin lyase-like | 41 | 5 |  |
| GroES-like | NAD(P)-binding Rossmann-fold domains | 41 | 12 |  |
| Protein kinase-like (PK-like) | Protein kinase-like (PK-like) | 40 | 29 |  |
| Calcium ATPase, transduction domain A | Metal cation-transporting ATPase, ATP-binding domain N | 39 | 9 |  |
| NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 38 | 12 |  |
| ENTH/VHS domain | GAT-like domain | 37 | 8 |  |
| NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 37 | 17 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | Riboflavin synthase domain-like | 36 | 16 |  |
| DNA-binding domain | DNA-binding domain | 36 | 5 |  |
| ABC transporter transmembrane region | ABC transporter transmembrane region | 35 | 10 |  |
| Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 35 | 11 |  |
| Voltage-gated potassium channels | cAMP-binding domain-like | 35 | 14 |  |
| Concanavalin A-like lectins/glucanases | Protein kinase-like (PK-like) | 35 | 12 |  |
| P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 34 | 19 |  |
| Ribonuclease H-like | Chromo domain-like | 34 | 12 |  |
| Galactose-binding domain-like | (Trans)glycosidases | 32 | 14 |  |
| ACT-like | ACT-like | 32 | 12 |  |
| (Trans)glycosidases | Glycosyl hydrolase domain | 31 | 10 |  |
| FAD/NAD(P)-binding domain | FAD-linked reductases, C-terminal domain | 31 | 14 |  |
| Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 30 | 13 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | C2 domain (Calcium/lipid-binding domain, CaLB) | 30 | 10 |  |
| beta-beta-alpha zinc fingers | beta-beta-alpha zinc fingers | 29 | 13 |  |
| DNA-binding pseudobarrel domain | CAD & PB1 domains | 29 | 5 |  |
| HSP40/DnaJ peptide-binding domain | HSP40/DnaJ peptide-binding domain | 28 | 18 |  |
| CCCH zinc finger | CCCH zinc finger | 28 | 19 |  |
| WRKY DNA-binding domain | WRKY DNA-binding domain | 28 | 8 |  |
| Chaperone J-domain | HSP40/DnaJ peptide-binding domain | 28 | 18 |  |
| Thioredoxin-like | Thioredoxin-like | 28 | 20 |  |
| Homeodomain-like | Bet v1-like | 28 | 10 |  |
| "Winged helix" DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 27 | 6 |  |
| Actin-like ATPase domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 26 | 8 |  |
| GroEL equatorial domain-like | GroEL apical domain-like | 25 | 9 |  |
| GroEL-intermediate domain like | GroEL apical domain-like | 25 | 9 |  |
| GroEL equatorial domain-like | GroEL-intermediate domain like | 24 | 8 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | (Trans)glycosidases | 24 | 11 |  |
| Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 24 | 8 |  |
| Galactose-binding domain-like | Galactose-binding domain-like | 24 | 8 |  |
| Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 24 | 7 |  |
| Eukaryotic type KH-domain (KH-domain type I) | Eukaryotic type KH-domain (KH-domain type I) | 24 | 15 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 23 | 10 |  |
| Bet v1-like | Bet v1-like | 23 | 9 |  |
| Nucleic acid-binding proteins | Nucleic acid-binding proteins | 22 | 17 |  |
| Ypt/Rab-GAP domain of gyp1p | Ypt/Rab-GAP domain of gyp1p | 22 | 11 |  |
| NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 22 | 17 |  |
| PK beta-barrel domain-like | Phosphoenolpyruvate/pyruvate domain | 22 | 10 |  |
| Retrovirus zinc finger-like domains | Retrovirus zinc finger-like domains | 22 | 14 |  |
| Phosphoenolpyruvate/pyruvate domain | PK C-terminal domain-like | 21 | 7 |  |
| Terpenoid cyclases/Protein prenyltransferases | Terpenoid synthases | 21 | 8 |  |
| FAD-binding/transporter-associated domain-like | FAD-linked oxidases, C-terminal domain | 21 | 6 |  |
| RING/U-box | RING/U-box | 20 | 14 |  |
| Protein kinase-like (PK-like) | ARM repeat | 20 | 19 |  |
| Subtilisin-like | PA domain | 20 | 3 |  |
| Double Clp-N motif | P-loop containing nucleoside triphosphate hydrolases | 20 | 9 |  |
| F-box domain | Galactose oxidase, central domain | 19 | 5 |  |
| Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 19 | 11 |  |
| Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 19 | 7 |  |
| Nucleotidyltransferase | PAP/OAS1 substrate-binding domain | 19 | 11 |  |
| P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 19 | 7 |  |
| Periplasmic binding protein-like I | Periplasmic binding protein-like II | 19 | 6 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | AN1-like Zinc finger | 18 | 2 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | Glucocorticoid receptor-like (DNA-binding domain) | 18 | 8 |  |
| Ubiquitin-like | Ubiquitin-like | 18 | 14 |  |
| Ran binding protein zinc finger-like | Ran binding protein zinc finger-like | 18 | 14 |  |
| RING/U-box | Nucleotide-diphospho-sugar transferases | 18 | 6 |  |
| Periplasmic binding protein-like II | ACT-like | 17 | 5 |  |
| POZ domain | Ankyrin repeat | 17 | 4 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | HAD-like | 17 | 10 |  |
| Chaperone J-domain | DnaJ/Hsp40 cysteine-rich domain | 17 | 14 |  |
| CBS-domain pair | CBS-domain pair | 17 | 12 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 17 | 10 |  |
| DnaJ/Hsp40 cysteine-rich domain | HSP40/DnaJ peptide-binding domain | 17 | 14 |  |
| HMA, heavy metal-associated domain | HMA, heavy metal-associated domain | 16 | 9 |  |
| Purple acid phosphatase, N-terminal domain | Metallo-dependent phosphatases | 16 | 7 |  |
| PK beta-barrel domain-like | PK C-terminal domain-like | 16 | 6 |  |
| Acid proteases | Chromo domain-like | 16 | 7 |  |
| DNA-binding domain | DNA-binding pseudobarrel domain | 16 | 4 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 16 | 5 |  |
| MFS general substrate transporter | MFS general substrate transporter | 16 | 5 |  |
| P-loop containing nucleoside triphosphate hydrolases | FtsH protease domain-like | 16 | 6 |  |
| Phospholipase D/nuclease | Phospholipase D/nuclease | 16 | 9 |  |
| GroES-like | GroES-like | 16 | 11 |  |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | Lipoxigenase | 16 | 4 |  |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | SAICAR synthase-like | 15 | 7 |  |
| P-loop containing nucleoside triphosphate hydrolases | RNI-like | 15 | 11 |  |
| RING/U-box | vWA-like | 15 | 8 |  |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 15 | 9 |  |
| RNA-binding domain, RBD | Retrovirus zinc finger-like domains | 15 | 6 |  |
| WD40 repeat-like | WD40 repeat-like | 15 | 9 |  |
| alpha-D-mannose-specific plant lectins | alpha-D-mannose-specific plant lectins | 15 | 9 |  |
| NAD(P)-binding Rossmann-fold domains | LDH C-terminal domain-like | 15 | 3 |  |
| LuxS/MPP-like metallohydrolase | LuxS/MPP-like metallohydrolase | 15 | 12 |  |
| EF-hand | EF-hand | 15 | 7 |  |
| Protein kinase-like (PK-like) | Adenine nucleotide alpha hydrolases-like | 15 | 6 |  |
| CheY-like | Homeodomain-like | 14 | 4 |  |
| Ubiquitin-like | UBA-like | 14 | 10 |  |
| Actin depolymerizing proteins | Actin depolymerizing proteins | 14 | 12 |  |
| RNA-binding domain, RBD | CCCH zinc finger | 14 | 7 |  |
| SNARE-like | SNARE fusion complex | 14 | 7 |  |
| POZ domain | Skp1 dimerisation domain-like | 14 | 5 |  |
| Protein kinase-like (PK-like) | TPR-like | 14 | 6 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | TK C-terminal domain-like | 14 | 6 |  |
| vWA-like | beta-sandwich domain of Sec23/24 | 14 | 13 |  |
| PAZ domain | Ribonuclease H-like | 13 | 7 |  |
| Cullin homology domain | "Winged helix" DNA-binding domain | 13 | 4 |  |
| Riboflavin synthase domain-like | EF-hand | 13 | 3 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | EF-hand | 13 | 3 |  |
| NTF2-like | RNA-binding domain, RBD | 13 | 3 |  |
| Cullin repeat-like | Cullin homology domain | 13 | 4 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Phospholipase D/nuclease | 13 | 8 |  |
| FYVE/PHD zinc finger | RING/U-box | 13 | 12 |  |
| EGF/Laminin | Protein kinase-like (PK-like) | 13 | 3 |  |
| HCP-like | TPR-like | 13 | 9 |  |
| P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 12 | 7 |  |
| Homodimeric domain of signal transducing histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 12 | 9 |  |
| Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 12 | 7 |  |
| Protein kinase-like (PK-like) | RING/U-box | 12 | 8 |  |
| Cullin repeat-like | "Winged helix" DNA-binding domain | 12 | 3 |  |
| beta-sandwich domain of Sec23/24 | Helical domain of Sec23/24 | 12 | 11 |  |
| Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 12 | 10 |  |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 12 | 8 |  |
| Zn-finger domain of Sec23/24 | vWA-like | 12 | 11 |  |
| FAS1 domain | FAS1 domain | 12 | 4 |  |
| HMA, heavy metal-associated domain | Calcium ATPase, transduction domain A | 12 | 9 |  |
| Clc chloride channel | CBS-domain pair | 12 | 5 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ankyrin repeat | 12 | 7 |  |
| HMA, heavy metal-associated domain | HAD-like | 12 | 9 |  |
| Ankyrin repeat | Protein kinase-like (PK-like) | 11 | 6 |  |
| Protein kinase-like (PK-like) | WD40 repeat-like | 11 | 8 |  |
| (Trans)glycosidases | (Trans)glycosidases | 11 | 7 |  |
| Ribosomal protein S5 domain 2-like | HSP90 C-terminal domain | 11 | 5 |  |
| Ubiquitin-like | Zn-binding ribosomal proteins | 11 | 3 |  |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 11 | 5 |  |
| Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 11 | 6 |  |
| PLP-dependent transferases | PLP-dependent transferases | 11 | 7 |  |
| dsRNA-binding domain-like | dsRNA-binding domain-like | 11 | 7 |  |
| Zn-finger domain of Sec23/24 | beta-sandwich domain of Sec23/24 | 11 | 10 |  |
| Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 11 | 5 |  |
| Translation proteins SH3-like domain | Nucleic acid-binding proteins | 11 | 9 |  |
| ARM repeat | WD40 repeat-like | 11 | 10 |  |
| Homodimeric domain of signal transducing histidine kinase | CheY-like | 11 | 7 |  |
| Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 11 | 9 |  |
| HMA, heavy metal-associated domain | Calcium ATPase, transmembrane domain M | 11 | 8 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | HSP90 C-terminal domain | 11 | 5 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | CheY-like | 11 | 8 |  |
| vWA-like | Helical domain of Sec23/24 | 11 | 10 |  |
| NAD(P)-binding Rossmann-fold domains | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 10 | 4 |  |
| beta-sandwich domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 10 | 10 |  |
| POZ domain | TRAF domain-like | 10 | 3 |  |
| FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 10 | 4 |  |
| PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 10 | 10 |  |
| Zn-finger domain of Sec23/24 | Helical domain of Sec23/24 | 10 | 9 |  |
| FYVE/PHD zinc finger | P-loop containing nucleoside triphosphate hydrolases | 10 | 7 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 10 | 8 |  |
| RING/U-box | P-loop containing nucleoside triphosphate hydrolases | 10 | 7 |  |
| S-adenosylmethionine synthetase | S-adenosylmethionine synthetase | 10 | 2 |  |
| Thioesterase/thiol ester dehydrase-isomerase | Thioesterase/thiol ester dehydrase-isomerase | 10 | 3 |  |
| cAMP-binding domain-like | Ankyrin repeat | 10 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 10 | 6 |  |
| CAD & PB1 domains | Protein kinase-like (PK-like) | 10 | 4 |  |
| Helical domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 10 | 10 |  |
| Concanavalin A-like lectins/glucanases | P-domain of calnexin/calreticulin | 10 | 3 |  |
| Voltage-gated potassium channels | Ankyrin repeat | 10 | 4 |  |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 10 | 6 |  |
| HCP-like | HCP-like | 9 | 8 |  |
| Ubiquitin-like | BAG domain | 9 | 4 |  |
| HCP-like | HIT/MYND zinc finger-like | 9 | 5 |  |
| P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 9 | 7 |  |
| Nucleotide-diphospho-sugar transferases | Trimeric LpxA-like enzymes | 9 | 3 |  |
| Nucleotide-diphospho-sugar transferases | Nucleotide-diphospho-sugar transferases | 9 | 7 |  |
| P-loop containing nucleoside triphosphate hydrolases | Class I glutamine amidotransferase-like | 9 | 4 |  |
| Translation proteins | EF-G C-terminal domain-like | 9 | 7 |  |
| E set domains | P-loop containing nucleoside triphosphate hydrolases | 9 | 4 |  |
| FYVE/PHD zinc finger | FYVE/PHD zinc finger | 9 | 6 |  |
| Calponin-homology domain, CH-domain | P-loop containing nucleoside triphosphate hydrolases | 9 | 4 |  |
| RING/U-box | WD40 repeat-like | 9 | 9 |  |
| SNARE-like | Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 9 | 6 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | DHS-like NAD/FAD-binding domain | 9 | 2 |  |
| HLH, helix-loop-helix DNA-binding domain | ACT-like | 9 | 4 |  |
| RCC1/BLIP-II | FYVE/PHD zinc finger | 9 | 3 |  |
| ARM repeat | Clathrin adaptor appendage domain | 9 | 8 |  |
| RCC1/BLIP-II | Protein kinase-like (PK-like) | 9 | 3 |  |
| Cytochrome P450 | Cytochrome P450 | 9 | 3 |  |
| vWA-like | C-terminal, gelsolin-like domain of Sec23/24 | 9 | 9 |  |
| Cdc48 domain 2-like | P-loop containing nucleoside triphosphate hydrolases | 9 | 7 |  |
| Sigma2 domain of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 9 | 5 |  |
| WD40 repeat-like | Quinoprotein alcohol dehydrogenase-like | 9 | 7 |  |
| Single hybrid motif | CoA-dependent acyltransferases | 8 | 6 |  |
| ARM repeat | Sec7 domain | 8 | 4 |  |
| Homeodomain-like | P-loop containing nucleoside triphosphate hydrolases | 8 | 7 |  |
| Transducin (alpha subunit), insertion domain | P-loop containing nucleoside triphosphate hydrolases | 8 | 4 |  |
| Ankyrin repeat | RING/U-box | 8 | 3 |  |
| Amine oxidase N-terminal region | Amine oxidase N-terminal region | 8 | 6 |  |
| PH domain-like | Oxysterol-binding protein-like | 8 | 3 |  |
| Enolase N-terminal domain-like | Enolase C-terminal domain-like | 8 | 6 |  |
| PH domain-like | RCC1/BLIP-II | 8 | 2 |  |
| PYP-like sensor domain (PAS domain) | PYP-like sensor domain (PAS domain) | 8 | 7 |  |
| PH domain-like | FYVE/PHD zinc finger | 8 | 2 |  |
| RNA-binding domain, RBD | PABC (PABP) domain | 8 | 5 |  |
| Ribosomal protein S5 domain 2-like | Ribonuclease PH domain 2-like | 8 | 6 |  |
| E set domains | Ankyrin repeat | 8 | 4 |  |
| (Phosphotyrosine protein) phosphatases II | C2 domain (Calcium/lipid-binding domain, CaLB) | 8 | 4 |  |
| Nucleic acid-binding proteins | Retrovirus zinc finger-like domains | 8 | 6 |  |
| Amine oxidase N-terminal region | Amine oxidase catalytic domain | 8 | 6 |  |
| Zn-finger domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 8 | 8 |  |
| EF-G C-terminal domain-like | EF-G C-terminal domain-like | 8 | 6 |  |
| FKBP-like | FKBP-like | 8 | 5 |  |
| Glutamine synthetase, N-terminal domain | Glutamine synthetase/guanido kinase | 8 | 2 |  |
| Cysteine proteinases | Granulin repeat | 8 | 2 |  |
| Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 8 | 8 |  |
| Trypsin-like serine proteases | PDZ domain-like | 8 | 5 |  |
| Acid proteases | Saposin | 8 | 5 |  |
| Actin depolymerizing proteins | VHP, Villin headpiece domain | 8 | 7 |  |
| Sigma3 and sigma4 domains of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 8 | 4 |  |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | Fe,Mn superoxide dismutase (SOD), C-terminal domain | 7 | 5 |  |
| ArfGap/RecO-like zinc finger | C2 domain (Calcium/lipid-binding domain, CaLB) | 7 | 4 |  |
| "Winged helix" DNA-binding domain | RNA-binding domain, RBD | 7 | 4 |  |
| Acyl-CoA dehydrogenase NM domain-like | Acyl-CoA dehydrogenase C-terminal domain-like | 7 | 6 |  |
| EF-hand | P-loop containing nucleoside triphosphate hydrolases | 7 | 3 |  |
| UBA-like | UBA-like | 7 | 5 |  |
| P-loop containing nucleoside triphosphate hydrolases | Retrovirus zinc finger-like domains | 7 | 6 |  |
| Nucleotidylyl transferase | Nucleotidylyl transferase | 7 | 5 |  |
| beta-beta-alpha zinc fingers | Ribonuclease H-like | 7 | 5 |  |
| Cryptochrome/photolyase, N-terminal domain | Cryptochrome/photolyase FAD-binding domain | 7 | 6 |  |
| Galactose mutarotase-like | (Trans)glycosidases | 7 | 4 |  |
| GroEL apical domain-like | SAICAR synthase-like | 7 | 5 |  |
| Protein kinase-like (PK-like) | Ubiquitin-like | 7 | 6 |  |
| RCC1/BLIP-II | RCC1/BLIP-II | 7 | 2 |  |
| Ribonuclease H-like | Protein kinase-like (PK-like) | 7 | 7 |  |
| Protein kinase-like (PK-like) | P-loop containing nucleoside triphosphate hydrolases | 7 | 7 |  |
| Galactose oxidase, central domain | E set domains | 7 | 2 |  |
| Voltage-gated potassium channels | Voltage-gated potassium channels | 7 | 5 |  |
| DNA/RNA polymerases | Protein kinase-like (PK-like) | 7 | 7 |  |
| ISP domain | Bet v1-like | 7 | 3 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Formin homology 2 domain (FH2 domain) | 7 | 4 |  |
| ARM repeat | P-loop containing nucleoside triphosphate hydrolases | 7 | 6 |  |
| RING/U-box | Cysteine proteinases | 7 | 5 |  |
| PreATP-grasp domain | Rudiment single hybrid motif | 7 | 7 |  |
| P-loop containing nucleoside triphosphate hydrolases | RNA-binding domain, RBD | 7 | 6 |  |
| DNA repair protein MutS, domain III | P-loop containing nucleoside triphosphate hydrolases | 7 | 7 |  |
| PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 7 | 5 |  |
| CRAL/TRIO N-terminal domain | Supernatant protein factor (SPF), C-terminal domain | 7 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 7 | 3 |  |
| FKBP-like | TPR-like | 7 | 4 |  |
| RmlC-like cupins | RmlC-like cupins | 7 | 4 |  |
| Clathrin adaptor appendage domain | Subdomain of clathrin and coatomer appendage domain | 7 | 6 |  |
| ARM repeat | Subdomain of clathrin and coatomer appendage domain | 7 | 6 |  |
| PUA domain-like | SET domain | 7 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 7 | 7 |  |
| PLC-like phosphodiesterases | PLC-like phosphodiesterases | 7 | 4 |  |
| CRAL/TRIO domain | Supernatant protein factor (SPF), C-terminal domain | 7 | 3 |  |
| YhbY-like | YhbY-like | 7 | 4 |  |
| TPR-like | Thioredoxin-like | 7 | 4 |  |
| Ribosomal L11/L12e N-terminal domain | Ribosomal protein L11, C-terminal domain | 7 | 1 |  |
| GAF domain-like | Homodimeric domain of signal transducing histidine kinase | 7 | 6 |  |
| NAD(P)-binding Rossmann-fold domains | ACT-like | 7 | 4 |  |
| Translation proteins | Ribosomal protein S5 domain 2-like | 6 | 4 |  |
| Translational machinery components | L30e-like | 6 | 2 |  |
| F-box domain | HCP-like | 6 | 3 |  |
| DNA/RNA polymerases | F-box domain | 6 | 6 |  |
| PH domain-like | Bet v1-like | 6 | 3 |  |
| PLC-like phosphodiesterases | C2 domain (Calcium/lipid-binding domain, CaLB) | 6 | 3 |  |
| E set domains | (Trans)glycosidases | 6 | 6 |  |
| SWIB/MDM2 domain | Plus3-like | 6 | 5 |  |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 6 | 3 |  |
| "Winged helix" DNA-binding domain | E2F-DP heterodimerization region | 6 | 6 |  |
| GAF domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 6 | 6 |  |
| NagB/RpiA/CoA transferase-like | D-ribose-5-phosphate isomerase (RpiA), lid domain | 6 | 2 |  |
| PYP-like sensor domain (PAS domain) | Protein kinase-like (PK-like) | 6 | 4 |  |
| CBS-domain pair | CAD & PB1 domains | 6 | 4 |  |
| F-box domain | Tubby C-terminal domain-like | 6 | 3 |  |
| MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, peptide-binding domain | 6 | 5 |  |
| dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 6 | 1 |  |
| ENT-like | Tudor/PWWP/MBT | 6 | 4 |  |
| Chromo domain-like | Chromo domain-like | 6 | 5 |  |
| Plant lectins/antimicrobial peptides | Lysozyme-like | 6 | 1 |  |
| FYVE/PHD zinc finger | Acyl-CoA N-acyltransferases (Nat) | 6 | 4 |  |
| Retrovirus zinc finger-like domains | Acid proteases | 6 | 5 |  |
| Flavoproteins | Riboflavin synthase domain-like | 6 | 4 |  |
| HAD-like | HAD-like | 6 | 5 |  |
| RING/U-box | Homeodomain-like | 6 | 6 |  |
| Acyl-CoA N-acyltransferases (Nat) | Acyl-CoA N-acyltransferases (Nat) | 6 | 3 |  |
| alpha/beta-Hydrolases | alpha/beta-Hydrolases | 6 | 5 |  |
| Kelch motif | Kelch motif | 6 | 4 |  |
| Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 6 | 5 |  |
| Arabinanase/levansucrase/invertase | Concanavalin A-like lectins/glucanases | 6 | 2 |  |
| Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 6 | 6 |  |
| Chaperone J-domain | Chaperone J-domain | 6 | 5 |  |
| RNase III domain-like | dsRNA-binding domain-like | 6 | 5 |  |
| Homeodomain-like | "Winged helix" DNA-binding domain | 6 | 3 |  |
| Ankyrin repeat | Ankyrin repeat | 6 | 4 |  |
| Flavoproteins | Ferredoxin reductase-like, C-terminal NADP-linked domain | 6 | 4 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | UDP-Glycosyltransferase/glycogen phosphorylase | 6 | 4 |  |
| ARM repeat | Hect, E3 ligase catalytic domain | 6 | 4 |  |
| ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 6 | 6 |  |
| TATA-box binding protein-like | TATA-box binding protein-like | 6 | 4 |  |
| DNA/RNA polymerases | ARM repeat | 6 | 6 |  |
| EF-G C-terminal domain-like | Ribosomal protein S5 domain 2-like | 6 | 4 |  |
| ClpP/crotonase | ClpP/crotonase | 6 | 6 |  |
| BAR/IMD domain-like | SH3-domain | 6 | 4 |  |
| PP2C-like | PP2C-like | 6 | 3 |  |
| BEACH domain | WD40 repeat-like | 6 | 4 |  |
| HD-domain/PDEase-like | Nucleotidyltransferase | 6 | 5 |  |
| PRTase-like | PRTase-like | 5 | 3 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | L30e-like | 5 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | Actin depolymerizing proteins | 5 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 5 | 4 |  |
| E set domains | Glycosyl hydrolase domain | 5 | 5 |  |
| PAP/OAS1 substrate-binding domain | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 5 | 3 |  |
| Activating enzymes of the ubiquitin-like proteins | Activating enzymes of the ubiquitin-like proteins | 5 | 4 |  |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 6-phosphogluconate dehydrogenase C-terminal domain-like | 5 | 4 |  |
| Homeodomain-like | FAD/NAD(P)-binding domain | 5 | 3 |  |
| F-box domain | WD40 repeat-like | 5 | 4 |  |
| DNA-binding pseudobarrel domain | DNA-binding pseudobarrel domain | 5 | 3 |  |
| UROD/MetE-like | UROD/MetE-like | 5 | 1 |  |
| TPR-like | CAD & PB1 domains | 5 | 3 |  |
| Leukotriene A4 hydrolase N-terminal domain | Metalloproteases ("zincins"), catalytic domain | 5 | 5 |  |
| PH domain-like | ArfGap/RecO-like zinc finger | 5 | 4 |  |
| ADC-like | P-loop containing nucleoside triphosphate hydrolases | 5 | 3 |  |
| Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 5 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 5 | 4 |  |
| POZ domain | TAZ domain | 5 | 4 |  |
| Zinc beta-ribbon | Cyclin-like | 5 | 4 |  |
| t-snare proteins | SNARE fusion complex | 5 | 3 |  |
| Galactose mutarotase-like | Galactose-binding domain-like | 5 | 5 |  |
| Acetyl-CoA synthetase-like | Acetyl-CoA synthetase-like | 5 | 3 |  |
| EF-hand | PLC-like phosphodiesterases | 5 | 2 |  |
| Clathrin heavy-chain terminal domain | ARM repeat | 5 | 4 |  |
| Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | 5 | 5 |  |
| BAR/IMD domain-like | ArfGap/RecO-like zinc finger | 5 | 4 |  |
| Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 5 | 5 |  |
| EF-hand | C2 domain (Calcium/lipid-binding domain, CaLB) | 5 | 2 |  |
| Translation proteins | Initiation factor IF2/eIF5b, domain 3 | 5 | 4 |  |
| YrdC/RibB | RibA-like | 5 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | DNA/RNA polymerases | 5 | 5 |  |
| BAR/IMD domain-like | PH domain-like | 5 | 4 |  |
| NAC domain | NAC domain | 5 | 3 |  |
| NAD(P)-binding Rossmann-fold domains | Protein kinase-like (PK-like) | 5 | 5 |  |
| ARM repeat | C2 domain (Calcium/lipid-binding domain, CaLB) | 5 | 5 |  |
| Transcription factor IIA (TFIIA), alpha-helical domain | Transcription factor IIA (TFIIA), beta-barrel domain | 5 | 3 |  |
| Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 5 | 5 |  |
| ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 5 | 5 |  |
| F-box domain | HIT/MYND zinc finger-like | 5 | 2 |  |
| Serine metabolism enzymes domain | ACT-like | 5 | 2 |  |
| ADC-like | Cdc48 domain 2-like | 5 | 3 |  |
| Concanavalin A-like lectins/glucanases | Concanavalin A-like lectins/glucanases | 5 | 4 |  |
| NAD(P)-binding Rossmann-fold domains | Serine metabolism enzymes domain | 5 | 2 |  |
| PAH2 domain | PAH2 domain | 5 | 3 |  |
| Single hybrid motif | Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 5 | 4 |  |
| Homeodomain-like | FAD-linked reductases, C-terminal domain | 5 | 3 |  |
| RNase III domain-like | RNase III domain-like | 5 | 5 |  |
| PLP-binding barrel | Alanine racemase C-terminal domain-like | 5 | 3 |  |
| alpha-D-mannose-specific plant lectins | Hairpin loop containing domain-like | 5 | 4 |  |
| RING/U-box | TRAF domain-like | 5 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | PH domain-like | 5 | 3 |  |
| UBA-like | XPC-binding domain | 5 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | dsRNA-binding domain-like | 5 | 4 |  |
| Nucleotidyltransferase | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 5 | 3 |  |
| TPR-like | Chaperone J-domain | 5 | 3 |  |
| ARM repeat | TPR-like | 5 | 4 |  |
| (Phosphotyrosine protein) phosphatases II | Formin homology 2 domain (FH2 domain) | 5 | 2 |  |
| F1F0 ATP synthase subunit C | F1F0 ATP synthase subunit C | 5 | 4 |  |
| Phosphoenolpyruvate/pyruvate domain | Phosphoenolpyruvate/pyruvate domain | 5 | 3 |  |
| Peptidase/esterase 'gauge' domain | alpha/beta-Hydrolases | 5 | 2 |  |
| Saposin | Saposin | 5 | 2 |  |
| EF-hand | Mitochondrial carrier | 5 | 2 |  |
| L domain-like | ARM repeat | 5 | 4 |  |
| DNase I-like | DNase I-like | 5 | 3 |  |
| Galactose mutarotase-like | Glycosyl hydrolase domain | 5 | 2 |  |
| Coiled-coil domain of nucleotide exchange factor GrpE | Head domain of nucleotide exchange factor GrpE | 5 | 3 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Translational machinery components | 5 | 1 |  |
| Thioredoxin-like | Ubiquitin-like | 5 | 4 |  |
| C-terminal, gelsolin-like domain of Sec23/24 | Actin depolymerizing proteins | 4 | 3 |  |
| UBA-like | Thioredoxin-like | 4 | 3 |  |
| Translation initiation factor 2 beta, aIF2beta, N-terminal domain | Zinc-binding domain of translation initiation factor 2 beta | 4 | 3 |  |
| Aldolase | NAD(P)-binding Rossmann-fold domains | 4 | 4 |  |
| POZ domain | TPR-like | 4 | 3 |  |
| FYVE/PHD zinc finger | SET domain | 4 | 3 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Adenine nucleotide alpha hydrolases-like | 4 | 2 |  |
| PYP-like sensor domain (PAS domain) | GAF domain-like | 4 | 4 |  |
| Metallo-dependent phosphatases | Metallo-dependent phosphatases | 4 | 2 |  |
| ARID-like | HMG-box | 4 | 4 |  |
| Fe-S cluster assembly (FSCA) domain-like | Fe-S cluster assembly (FSCA) domain-like | 4 | 4 |  |
| Terpenoid synthases | Terpenoid synthases | 4 | 2 |  |
| PH domain-like | GTPase activation domain, GAP | 4 | 3 |  |
| Translation proteins | Translation proteins | 4 | 4 |  |
| DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 4 | 4 |  |
| F-box domain | Quinoprotein alcohol dehydrogenase-like | 4 | 2 |  |
| FMN-linked oxidoreductases | Alpha subunit of glutamate synthase, C-terminal domain | 4 | 3 |  |
| Actin-crosslinking proteins | (Trans)glycosidases | 4 | 2 |  |
| E set domains | AMPKBI-like | 4 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | Hypothetical protein YjiA, C-terminal domain | 4 | 4 |  |
| GAF domain-like | GAF domain-like | 4 | 4 |  |
| Ubiquitin-like | Homeodomain-like | 4 | 2 |  |
| Oxidoreductase molybdopterin-binding domain | E set domains | 4 | 2 |  |
| NAD-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 4 | 3 |  |
| Elongation factor TFIIS domain 2 | Zinc beta-ribbon | 4 | 3 |  |
| GAF domain-like | CheY-like | 4 | 3 |  |
| LysM domain | LysM domain | 4 | 2 |  |
| PH domain-like | Ankyrin repeat | 4 | 3 |  |
| Acyl-CoA dehydrogenase C-terminal domain-like | Acyl-CoA dehydrogenase C-terminal domain-like | 4 | 3 |  |
| HAD-like | Glycerol-3-phosphate (1)-acyltransferase | 4 | 2 |  |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 4 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | PRTase-like | 4 | 3 |  |
| Arabinanase/levansucrase/invertase | Nucleotide-diphospho-sugar transferases | 4 | 2 |  |
| Glycoside hydrolase/deacetylase | Families 57/38 glycoside transferase middle domain | 4 | 4 |  |
| PYP-like sensor domain (PAS domain) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 4 | 4 |  |
| ArfGap/RecO-like zinc finger | Ankyrin repeat | 4 | 3 |  |
| Cytidine deaminase-like | Cytidine deaminase-like | 4 | 2 |  |
| DNase I-like | EF-hand | 4 | 3 |  |
| Ribosomal protein L7/12, oligomerisation (N-terminal) domain | ClpS-like | 4 | 2 |  |
| Cytochrome b5-like heme/steroid binding domain | Ferredoxin reductase-like, C-terminal NADP-linked domain | 4 | 2 |  |
| Class I glutamine amidotransferase-like | Class I glutamine amidotransferase-like | 4 | 4 |  |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | CoA-dependent acyltransferases | 4 | 3 |  |
| alpha/beta-Hydrolases | RING/U-box | 4 | 4 |  |
| Kelch motif | Metallo-dependent phosphatases | 4 | 3 |  |
| Carbamate kinase-like | ACT-like | 4 | 4 |  |
| PGBD-like | Metalloproteases ("zincins"), catalytic domain | 4 | 1 |  |
| HMA, heavy metal-associated domain | P-loop containing nucleoside triphosphate hydrolases | 4 | 4 |  |
| UBC-like | UBC-like | 4 | 3 |  |
| SBT domain | Ankyrin repeat | 4 | 2 |  |
| ARID-like | FYVE/PHD zinc finger | 4 | 4 |  |
| PUA domain-like | Nucleotidylyl transferase | 4 | 2 |  |
| Thioredoxin-like | Cysteine-rich domain | 4 | 4 |  |
| Protein kinase-like (PK-like) | F-box domain | 4 | 4 |  |
| GST C-terminal domain-like | GST C-terminal domain-like | 4 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | RNase III domain-like | 4 | 4 |  |
| Class II aaRS and biotin synthetases | ThrRS/AlaRS common domain | 4 | 4 |  |
| LysM domain | Protein kinase-like (PK-like) | 4 | 3 |  |
| Protein kinase-like (PK-like) | (Phosphotyrosine protein) phosphatases II | 4 | 3 |  |
| "Winged helix" DNA-binding domain | "Winged helix" DNA-binding domain | 4 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Bromodomain | 4 | 2 |  |
| Mitochondrial carrier | Mitochondrial carrier | 4 | 1 |  |
| TRAF domain-like | Cysteine proteinases | 4 | 2 |  |
| NAC domain | Ribonuclease H-like | 4 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | NAD(P)-binding Rossmann-fold domains | 4 | 3 |  |
| Rap30/74 interaction domains | "Winged helix" DNA-binding domain | 4 | 3 |  |
| FYVE/PHD zinc finger | Transducin (alpha subunit), insertion domain | 4 | 2 |  |
| Homeodomain-like | Bromodomain | 4 | 2 |  |
| DNA/RNA polymerases | Homeodomain-like | 4 | 4 |  |
| Ribonuclease H-like | HLH, helix-loop-helix DNA-binding domain | 4 | 4 |  |
| Glutathione synthetase ATP-binding domain-like | Succinyl-CoA synthetase domains | 4 | 2 |  |
| DPP6 N-terminal domain-like | alpha/beta-Hydrolases | 4 | 3 |  |
| Mannose-binding lectins | Mannose-binding lectins | 4 | 3 |  |
| Ribonuclease H-like | Nucleic acid-binding proteins | 4 | 4 |  |
| Aldolase | Aldolase | 4 | 2 |  |
| TRAF domain-like | TRAF domain-like | 4 | 4 |  |
| Toll/Interleukin receptor TIR domain | P-loop containing nucleoside triphosphate hydrolases | 4 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 4 | 3 |  |
| Cytochrome b5-like heme/steroid binding domain | Riboflavin synthase domain-like | 4 | 2 |  |
| Families 57/38 glycoside transferase middle domain | Galactose mutarotase-like | 4 | 4 |  |
| (Trans)glycosidases | Chitinase insertion domain | 4 | 2 |  |
| C-terminal, gelsolin-like domain of Sec23/24 | VHP, Villin headpiece domain | 4 | 3 |  |
| SET domain | RuBisCo LSMT C-terminal, substrate-binding domain | 4 | 3 |  |
| ARM repeat | Tudor/PWWP/MBT | 4 | 4 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | FMN-linked oxidoreductases | 4 | 3 |  |
| Protein kinase-like (PK-like) | PP2C-like | 4 | 3 |  |
| Growth factor receptor domain | Protein kinase-like (PK-like) | 4 | 3 |  |
| ClpP/crotonase | NAD(P)-binding Rossmann-fold domains | 4 | 3 |  |
| Ubiquitin-like | XPC-binding domain | 4 | 2 |  |
| ARM repeat | Concanavalin A-like lectins/glucanases | 4 | 4 |  |
| UBC-like | Endosomal sorting complex assembly domain | 4 | 3 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | ACT-like | 4 | 1 |  |
| BRCT domain | BRCT domain | 4 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | NTF2-like | 4 | 3 |  |
| ClpP/crotonase | 6-phosphogluconate dehydrogenase C-terminal domain-like | 4 | 3 |  |
| Ran binding protein zinc finger-like | RNA-binding domain, RBD | 4 | 3 |  |
| BAR/IMD domain-like | Ankyrin repeat | 4 | 3 |  |
| WD40 repeat-like | DPP6 N-terminal domain-like | 4 | 3 |  |
| HAD-like | BRCT domain | 4 | 3 |  |
| CoA-dependent acyltransferases | CoA-dependent acyltransferases | 4 | 3 |  |
| Tetrahydrobiopterin biosynthesis enzymes-like | Tetrahydrobiopterin biosynthesis enzymes-like | 4 | 4 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | Serine metabolism enzymes domain | 4 | 1 |  |
| RING/U-box | RNA-binding domain, RBD | 4 | 3 |  |
| Glycoside hydrolase/deacetylase | Galactose mutarotase-like | 4 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | TGS-like | 4 | 4 |  |
| Heme-dependent peroxidases | Heme-dependent peroxidases | 4 | 3 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | P-loop containing nucleoside triphosphate hydrolases | 4 | 4 |  |
| Aconitase iron-sulfur domain | LeuD/IlvD-like | 4 | 4 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Alpha subunit of glutamate synthase, C-terminal domain | 4 | 3 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | FAD/NAD(P)-binding domain | 3 | 2 |  |
| Starch-binding domain-like | Galactose-binding domain-like | 3 | 3 |  |
| CheY-like | CheY-like | 3 | 2 |  |
| Thioredoxin-like | "Winged helix" DNA-binding domain | 3 | 1 |  |
| Oxidoreductase molybdopterin-binding domain | Cytochrome b5-like heme/steroid binding domain | 3 | 1 |  |
| CO dehydrogenase flavoprotein C-terminal domain-like | CO dehydrogenase molybdoprotein N-domain-like | 3 | 3 |  |
| DNA/RNA polymerases | Lesion bypass DNA polymerase (Y-family), little finger domain | 3 | 3 |  |
| LEA14-like | LEA14-like | 3 | 3 |  |
| DNA repair protein MutS, domain II | DNA repair protein MutS, domain III | 3 | 3 |  |
| Oxidoreductase molybdopterin-binding domain | Ferredoxin reductase-like, C-terminal NADP-linked domain | 3 | 1 |  |
| HAD-like | dsRNA-binding domain-like | 3 | 2 |  |
| HAD-like | Riboflavin kinase-like | 3 | 3 |  |
| Domain of poly(ADP-ribose) polymerase | ADP-ribosylation | 3 | 3 |  |
| Amine oxidase catalytic domain | Amine oxidase catalytic domain | 3 | 3 |  |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 3 | 2 |  |
| Pectin lyase-like | Pectin lyase-like | 3 | 3 |  |
| Sec63 N-terminal domain-like | E set domains | 3 | 2 |  |
| Translation initiation factor 2 beta, aIF2beta, N-terminal domain | ARM repeat | 3 | 2 |  |
| CO dehydrogenase molybdoprotein N-domain-like | Molybdenum cofactor-binding domain | 3 | 3 |  |
| DNA primase core | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| CO dehydrogenase flavoprotein C-terminal domain-like | Molybdenum cofactor-binding domain | 3 | 3 |  |
| MIT domain | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 |  |
| Acid proteases | ARM repeat | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 3 | 3 |  |
| Tubby C-terminal domain-like | Tubby C-terminal domain-like | 3 | 2 |  |
| PYP-like sensor domain (PAS domain) | Homodimeric domain of signal transducing histidine kinase | 3 | 3 |  |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | Alkaline phosphatase-like | 3 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Type II DNA topoisomerase | 3 | 2 |  |
| FAD-binding/transporter-associated domain-like | CO dehydrogenase molybdoprotein N-domain-like | 3 | 3 |  |
| RNI-like | ARM repeat | 3 | 3 |  |
| Cysteine proteinases | DUSP-like | 3 | 3 |  |
| CO dehydrogenase ISP C-domain like | FAD-binding/transporter-associated domain-like | 3 | 3 |  |
| DNA repair protein MutS, domain I | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| TAZ domain | RING/U-box | 3 | 3 |  |
| Rad51 N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| NAD(P)-binding Rossmann-fold domains | Citrate synthase | 3 | 3 |  |
| Chaperone J-domain | 4Fe-4S ferredoxins | 3 | 3 |  |
| Adenine nucleotide alpha hydrolases-like | RING/U-box | 3 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | Phosphoenolpyruvate/pyruvate domain | 3 | 3 |  |
| DNA/RNA polymerases | HLH, helix-loop-helix DNA-binding domain | 3 | 3 |  |
| DNase I-like | DNA/RNA polymerases | 3 | 2 |  |
| Protein kinase-like (PK-like) | KA1-like | 3 | 3 |  |
| DNase I-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| Clavaminate synthase-like | Clavaminate synthase-like | 3 | 3 |  |
| Starch-binding domain-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 |  |
| WGR domain-like | ADP-ribosylation | 3 | 3 |  |
| NAD(P)-binding Rossmann-fold domains | DNA/RNA polymerases | 3 | 3 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | alpha-helical ferredoxin | 3 | 2 |  |
| L domain-like | Thioredoxin-like | 3 | 3 |  |
| Heme oxygenase-like | HAD-like | 3 | 2 |  |
| N-terminal domain of adenylylcyclase associated protein, CAP | C-terminal domain of adenylylcyclase associated protein | 3 | 3 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | Formate/glycerate dehydrogenase catalytic domain-like | 3 | 2 |  |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | Zinc beta-ribbon | 3 | 2 |  |
| CCCH zinc finger | Eukaryotic type KH-domain (KH-domain type I) | 3 | 3 |  |
| Cystatin/monellin | Cystatin/monellin | 3 | 2 |  |
| Obg GTP-binding protein N-terminal domain | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| TPR-like | S-adenosyl-L-methionine-dependent methyltransferases | 3 | 3 |  |
| Nucleic acid-binding proteins | Eukaryotic type KH-domain (KH-domain type I) | 3 | 2 |  |
| FAD-binding/transporter-associated domain-like | FAD-binding/transporter-associated domain-like | 3 | 3 |  |
| PUA domain-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| Nitrite and sulphite reductase 4Fe-4S domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 3 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | PAZ domain | 3 | 3 |  |
| SNARE fusion complex | SNARE fusion complex | 3 | 2 |  |
| TPR-like | "Winged helix" DNA-binding domain | 3 | 2 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | beta and beta-prime subunits of DNA dependent RNA-polymerase | 3 | 2 |  |
| FYVE/PHD zinc finger | Homeodomain-like | 3 | 2 |  |
| Six-hairpin glycosidases | AbfB domain | 3 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Glutamyl tRNA-reductase dimerization domain | 3 | 1 |  |
| WW domain | FF domain | 3 | 3 |  |
| SAP domain | FYVE/PHD zinc finger | 3 | 3 |  |
| Thioredoxin-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| SNARE-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| E set domains | Ferredoxin reductase-like, C-terminal NADP-linked domain | 3 | 1 |  |
| Hairpin loop containing domain-like | Protein kinase-like (PK-like) | 3 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ribonuclease H-like | 3 | 3 |  |
| DNA repair protein MutS, domain II | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| Leucine zipper domain | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 |  |
| WW domain | WW domain | 3 | 3 |  |
| FAD/NAD(P)-binding domain | EF-hand | 3 | 2 |  |
| E set domains | Cytochrome b5-like heme/steroid binding domain | 3 | 1 |  |
| beta-N-acetylhexosaminidase-like domain | (Trans)glycosidases | 3 | 3 |  |
| TAZ domain | FYVE/PHD zinc finger | 3 | 3 |  |
| E set domains | CBS-domain pair | 3 | 3 |  |
| ARM repeat | "Winged helix" DNA-binding domain | 3 | 2 |  |
| DNA repair protein MutS, domain I | DNA repair protein MutS, domain III | 3 | 3 |  |
| Cysteine proteinases | UBA-like | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | RecA protein, C-terminal domain | 3 | 2 |  |
| CO dehydrogenase ISP C-domain like | CO dehydrogenase molybdoprotein N-domain-like | 3 | 3 |  |
| Protein kinase-like (PK-like) | Leucine zipper domain | 3 | 2 |  |
| HAD-like | "Winged helix" DNA-binding domain | 3 | 3 |  |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | WD40 repeat-like | 3 | 3 |  |
| CorA soluble domain-like | Magnesium transport protein CorA, transmembrane region | 3 | 2 |  |
| Ribosomal L27 protein-like | Nucleic acid-binding proteins | 3 | 2 |  |
| vWA-like | vWA-like | 3 | 3 |  |
| RING/U-box | PUA domain-like | 3 | 3 |  |
| PDZ domain-like | ClpP/crotonase | 3 | 1 |  |
| MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, catalytic domain | 3 | 3 |  |
| Pseudouridine synthase | PUA domain-like | 3 | 1 |  |
| Terpenoid cyclases/Protein prenyltransferases | Terpenoid cyclases/Protein prenyltransferases | 3 | 3 |  |
| RNA-binding domain, RBD | Thioredoxin-like | 3 | 3 |  |
| Ribosomal protein L29 (L29p) | alpha/beta-Hydrolases | 3 | 2 |  |
| Protein kinase-like (PK-like) | MFS general substrate transporter | 3 | 3 |  |
| 2Fe-2S ferredoxin-like | alpha-helical ferredoxin | 3 | 2 |  |
| POZ domain | POZ domain | 3 | 3 |  |
| Tudor/PWWP/MBT | SET domain | 3 | 3 |  |
| Cytochrome c | Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor | 3 | 1 |  |
| Cysteine-rich domain | Cysteine-rich domain | 3 | 2 |  |
| Clavaminate synthase-like | beta-beta-alpha zinc fingers | 3 | 3 |  |
| DNA repair protein MutS, domain I | DNA repair protein MutS, domain II | 3 | 3 |  |
| RING/U-box | Ran binding protein zinc finger-like | 3 | 2 |  |
| Nucleotidyltransferase | Poly A polymerase C-terminal region-like | 3 | 3 |  |
| Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 3 | 3 |  |
| HLH, helix-loop-helix DNA-binding domain | HLH, helix-loop-helix DNA-binding domain | 3 | 3 |  |
| alpha-helical ferredoxin | FAD/NAD(P)-binding domain | 3 | 2 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | FAD/NAD(P)-binding domain | 3 | 2 |  |
| Elongation factor Ts (EF-Ts), dimerisation domain | Elongation factor Ts (EF-Ts), dimerisation domain | 3 | 3 |  |
| PriA/YqbF domain | GINS helical bundle-like | 3 | 3 |  |
| PAZ domain | RNase III domain-like | 3 | 3 |  |
| PEP carboxykinase N-terminal domain | PEP carboxykinase-like | 3 | 1 |  |
| Nitrite/Sulfite reductase N-terminal domain-like | Nitrite/Sulfite reductase N-terminal domain-like | 3 | 1 |  |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | DNA breaking-rejoining enzymes | 3 | 2 |  |
| Homeodomain-like | Ribonuclease H-like | 3 | 3 |  |
| TPR-like | Ribonuclease H-like | 3 | 3 |  |
| WGR domain-like | Domain of poly(ADP-ribose) polymerase | 3 | 3 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | alpha-helical ferredoxin | 3 | 2 |  |
| Protein kinase-like (PK-like) | HSP20-like chaperones | 3 | 3 |  |
| Zn-dependent exopeptidases | Transferrin receptor-like dimerisation domain | 3 | 2 |  |
| CO dehydrogenase ISP C-domain like | CO dehydrogenase flavoprotein C-terminal domain-like | 3 | 3 |  |
| Metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 3 | 3 |  |
| Zinc-binding domain of translation initiation factor 2 beta | ARM repeat | 3 | 2 |  |
| PYP-like sensor domain (PAS domain) | F-box domain | 3 | 3 |  |
| ARM repeat | UBA-like | 3 | 3 |  |
| Nicotinate/Quinolinate PRTase N-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 3 | 3 |  |
| Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 3 | 1 |  |
| L domain-like | WD40 repeat-like | 3 | 3 |  |
| Creatinase/aminopeptidase | "Winged helix" DNA-binding domain | 3 | 3 |  |
| Protease propeptides/inhibitors | Subtilisin-like | 3 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ran binding protein zinc finger-like | 3 | 3 |  |
| (Trans)glycosidases | Ricin B-like lectins | 3 | 3 |  |
| UBA-like | Hect, E3 ligase catalytic domain | 3 | 3 |  |
| FMN-linked oxidoreductases | FAD/NAD(P)-binding domain | 3 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | Phosphohistidine domain | 3 | 3 |  |
| Galactose-binding domain-like | NAD(P)-binding Rossmann-fold domains | 3 | 3 |  |
| SMAD/FHA domain | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| Concanavalin A-like lectins/glucanases | PH domain-like | 3 | 3 |  |
| Outer arm dynein light chain 1 | L domain-like | 3 | 3 |  |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | Tryptophan synthase beta subunit-like PLP-dependent enzymes | 3 | 3 |  |
| Chromo domain-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 |  |
| SWIB/MDM2 domain | SWIB/MDM2 domain | 3 | 3 |  |
| GST C-terminal domain-like | eEF1-gamma domain | 3 | 2 |  |
| CO dehydrogenase ISP C-domain like | Molybdenum cofactor-binding domain | 3 | 3 |  |
| FYVE/PHD zinc finger | SAICAR synthase-like | 3 | 3 |  |
| Oxidoreductase molybdopterin-binding domain | Riboflavin synthase domain-like | 3 | 1 |  |
| WRKY DNA-binding domain | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| WD40 repeat-like | DNase I-like | 3 | 3 |  |
| eIF2alpha middle domain-like | eIF-2-alpha, C-terminal domain | 3 | 2 |  |
| Nitrite/Sulfite reductase N-terminal domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 3 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 3 | 1 |  |
| FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 3 | 2 |  |
| FYVE/PHD zinc finger | GroEL apical domain-like | 3 | 3 |  |
| ISP transmembrane anchor | ISP domain | 3 | 2 |  |
| GST C-terminal domain-like | eEF-1beta-like | 3 | 3 |  |
| Ribosomal protein S5 domain 2-like | Type II DNA topoisomerase | 3 | 2 |  |
| Oxysterol-binding protein-like | Oxysterol-binding protein-like | 3 | 2 |  |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 3 | 2 |  |
| Ribosomal protein L6 | Ribosomal protein L6 | 3 | 1 |  |
| FYVE/PHD zinc finger | Chromo domain-like | 3 | 2 |  |
| L domain-like | Ribonuclease H-like | 3 | 3 |  |
| FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 3 | 2 |  |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | Glutamyl tRNA-reductase dimerization domain | 3 | 1 |  |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | Elongation factor TFIIS domain 2 | 3 | 2 |  |
| Surp module (SWAP domain) | Surp module (SWAP domain) | 3 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Smc hinge domain | 3 | 3 |  |
| FF domain | FF domain | 3 | 3 |  |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 3 | 1 |  |
| FMN-linked oxidoreductases | alpha-helical ferredoxin | 3 | 2 |  |
| Aldolase | Aminoacid dehydrogenase-like, N-terminal domain | 3 | 3 |  |
| FAD-binding/transporter-associated domain-like | CO dehydrogenase flavoprotein C-terminal domain-like | 3 | 3 |  |
| FAD-binding/transporter-associated domain-like | Molybdenum cofactor-binding domain | 3 | 3 |  |
| (Trans)glycosidases | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| E set domains | Riboflavin synthase domain-like | 3 | 1 |  |
| TPR-like | HSP20-like chaperones | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | HAD-like | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Sec63 N-terminal domain-like | 3 | 2 |  |
| Zn-dependent exopeptidases | Zn-dependent exopeptidases | 3 | 3 |  |
| Metalloproteases ("zincins"), catalytic domain | HAD-like | 2 | 2 |  |
| Nucleotide-diphospho-sugar transferases | NTF2-like | 2 | 1 |  |
| Methylglyoxal synthase-like | Cytidine deaminase-like | 2 | 2 |  |
| GYF domain | RNA-binding domain, RBD | 2 | 2 |  |
| Chlorophyll a-b binding protein | Chlorophyll a-b binding protein | 2 | 2 |  |
| RING/U-box | BRCT domain | 2 | 2 |  |
| PapD-like | Ankyrin repeat | 2 | 2 |  |
| UBA-like | Elongation factor Ts (EF-Ts), dimerisation domain | 2 | 2 |  |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 2 | 2 |  |
| TPR-like | FYVE/PHD zinc finger | 2 | 2 |  |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 2 | 2 |  |
| Second domain of FERM | PH domain-like | 2 | 2 |  |
| Nucleic acid-binding proteins | eIF-2-alpha, C-terminal domain | 2 | 1 |  |
| L domain-like | NAD(P)-binding Rossmann-fold domains | 2 | 2 |  |
| Ribosomal protein S5 domain 2-like | Nucleic acid-binding proteins | 2 | 2 |  |
| Nucleotidyltransferase | TGS-like | 2 | 2 |  |
| ARM repeat | alpha/beta-Hydrolases | 2 | 2 |  |
| Adenine nucleotide alpha hydrolases-like | Adenine nucleotide alpha hydrolases-like | 2 | 2 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | Protein kinase-like (PK-like) | 2 | 2 |  |
| N-terminal domain of MutM-like DNA repair proteins | S13-like H2TH domain | 2 | 2 |  |
| Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 2 | 2 |  |
| PA domain | RING/U-box | 2 | 2 |  |
| CCCH zinc finger | WD40 repeat-like | 2 | 1 |  |
| Protein kinase-like (PK-like) | Pectin lyase-like | 2 | 2 |  |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 2 | 2 |  |
| "Winged helix" DNA-binding domain | Protein kinase-like (PK-like) | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | HAND domain of the nucleosome remodeling ATPase ISWI | 2 | 2 |  |
| Tudor/PWWP/MBT | Protein kinase-like (PK-like) | 2 | 2 |  |
| Nucleic acid-binding proteins | Elongation factor Ts (EF-Ts), dimerisation domain | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ubiquitin-like | 2 | 2 |  |
| alpha/beta-Hydrolases | Ferredoxin reductase-like, C-terminal NADP-linked domain | 2 | 2 |  |
| Probable bacterial effector-binding domain | Probable bacterial effector-binding domain | 2 | 2 |  |
| (Trans)glycosidases | FAD-binding/transporter-associated domain-like | 2 | 2 |  |
| Class II aaRS and biotin synthetases | C-terminal domain of ProRS | 2 | 2 |  |
| FAD-binding/transporter-associated domain-like | RING/U-box | 2 | 2 |  |
| BRCT domain | Domain of poly(ADP-ribose) polymerase | 2 | 2 |  |
| Acid proteases | Acid proteases | 2 | 2 |  |
| F-box domain | ARM repeat | 2 | 2 |  |
| FYVE/PHD zinc finger | PUA domain-like | 2 | 2 |  |
| BRCT domain | FYVE/PHD zinc finger | 2 | 2 |  |
| Cyclophilin-like | Rubredoxin-like | 2 | 2 |  |
| Voltage-gated potassium channels | EF-hand | 2 | 1 |  |
| alpha/beta-Hydrolases | Protein kinase-like (PK-like) | 2 | 2 |  |
| Clavaminate synthase-like | Ribonuclease H-like | 2 | 2 |  |
| Nqo1 FMN-binding domain-like | Nqo1 middle domain-like | 2 | 2 |  |
| F-box domain | NTF2-like | 2 | 2 |  |
| PP2C-like | Bet v1-like | 2 | 2 |  |
| TPR-like | SET domain | 2 | 2 |  |
| Metalloproteases ("zincins"), catalytic domain | Metalloproteases ("zincins"), catalytic domain | 2 | 2 |  |
| L domain-like | (Trans)glycosidases | 2 | 2 |  |
| Homocysteine S-methyltransferase | Homocysteine S-methyltransferase | 2 | 2 |  |
| Concanavalin A-like lectins/glucanases | RING/U-box | 2 | 2 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Ribosomal protein S5 domain 2-like | 2 | 2 |  |
| Pentein | Translation proteins SH3-like domain | 2 | 1 |  |
| RNA-binding domain, RBD | WW domain | 2 | 2 |  |
| SBT domain | UBC-like | 2 | 2 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | PLP-dependent transferases | 2 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | Molybdenum cofactor biosynthesis proteins | 2 | 2 |  |
| SBT domain | SBT domain | 2 | 2 |  |
| Adenine nucleotide alpha hydrolases-like | GMP synthetase C-terminal dimerisation domain | 2 | 2 |  |
| Putative cyclase | Putative cyclase | 2 | 2 |  |
| Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 2 | 2 |  |
| Trypsin-like serine proteases | Trypsin-like serine proteases | 2 | 2 |  |
| PA domain | Transferrin receptor-like dimerisation domain | 2 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | Protein kinase-like (PK-like) | 2 | 2 |  |
| Nucleotidylyl transferase | Nucleic acid-binding proteins | 2 | 2 |  |
| PA domain | Zn-dependent exopeptidases | 2 | 1 |  |
| Nucleoside hydrolase | Nucleoside hydrolase | 2 | 2 |  |
| SWIB/MDM2 domain | eIF1-like | 2 | 2 |  |
| 2Fe-2S ferredoxin-like | Formate dehydrogenase/DMSO reductase, domains 1-3 | 2 | 2 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 2 |  |
| Aconitase iron-sulfur domain | Aconitase iron-sulfur domain | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | BRCT domain | 2 | 2 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Ribonuclease H-like | 2 | 2 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Protein kinase-like (PK-like) | 2 | 2 |  |
| Acyl-CoA binding protein | Kelch motif | 2 | 2 |  |
| Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain | 2 | 1 |  |
| RNA-binding domain, RBD | HAD-like | 2 | 2 |  |
| PH domain-like | Prismane protein-like | 2 | 2 |  |
| Ribosomal L27 protein-like | Eukaryotic type KH-domain (KH-domain type I) | 2 | 1 |  |
| Thioredoxin-like | eEF1-gamma domain | 2 | 1 |  |
| Clavaminate synthase-like | RNA-binding domain, RBD | 2 | 2 |  |
| WD40 repeat-like | C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 2 | 2 |  |
| PYP-like sensor domain (PAS domain) | Kelch motif | 2 | 2 |  |
| N-terminal, heterodimerisation domain of RBP7 (RpoE) | Nucleic acid-binding proteins | 2 | 2 |  |
| Chromo domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 2 |  |
| Protein kinase-like (PK-like) | PH domain-like | 2 | 1 |  |
| Tricorn protease N-terminal domain | DPP6 N-terminal domain-like | 2 | 2 |  |
| FAD/NAD(P)-binding domain | Nucleotide-binding domain | 2 | 2 |  |
| Nqo1 FMN-binding domain-like | Nqo1C-terminal domain-like | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 2 | 1 |  |
| RNI-like | DNA/RNA polymerases | 2 | 2 |  |
| MFS general substrate transporter | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 2 |  |
| Calponin-homology domain, CH-domain | EB1 dimerisation domain-like | 2 | 2 |  |
| Ypt/Rab-GAP domain of gyp1p | eIF1-like | 2 | 2 |  |
| HAD-like | Thioredoxin-like | 2 | 2 |  |
| Ran binding protein zinc finger-like | Leucine zipper domain | 2 | 2 |  |
| Kelch motif | Galactose oxidase, central domain | 2 | 2 |  |
| Rhodanese/Cell cycle control phosphatase | (Trans)glycosidases | 2 | 2 |  |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | Translation proteins | 2 | 2 |  |
| Protein kinase-like (PK-like) | FYVE/PHD zinc finger | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Inorganic pyrophosphatase | 2 | 2 |  |
| Protein kinase-like (PK-like) | Ribosomal proteins S24e, L23 and L15e | 2 | 1 |  |
| Calcyclin-binding protein-like | HSP20-like chaperones | 2 | 1 |  |
| SWIB/MDM2 domain | GYF domain | 2 | 2 |  |
| EF-hand | YhbY-like | 2 | 2 |  |
| Starch-binding domain-like | Phosphoglycerate mutase-like | 2 | 1 |  |
| NSFL1 (p97 ATPase) cofactor p47, SEP domain | Ubiquitin-like | 2 | 2 |  |
| Nucleic acid-binding proteins | UBA-like | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Prismane protein-like | 2 | 2 |  |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | SAM/Pointed domain | 2 | 2 |  |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | Quinoprotein alcohol dehydrogenase-like | 2 | 2 |  |
| Endosomal sorting complex assembly domain | VPS28 C-terminal domain-like | 2 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ypt/Rab-GAP domain of gyp1p | 2 | 2 |  |
| ARM repeat | Aldolase | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | HRDC-like | 2 | 2 |  |
| Carbamate kinase-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 2 | 2 |  |
| RNA-binding domain, RBD | CAD & PB1 domains | 2 | 2 |  |
| TPR-like | WD40 repeat-like | 2 | 2 |  |
| Type II DNA topoisomerase | Type II DNA topoisomerase | 2 | 2 |  |
| CCCH zinc finger | RING/U-box | 2 | 2 |  |
| Ribonuclease H-like | PLP-dependent transferases | 2 | 2 |  |
| NAC domain | GAT-like domain | 2 | 2 |  |
| SNARE-like | Domain of the SRP/SRP receptor G-proteins | 2 | 2 |  |
| Arp2/3 complex subunits | Arp2/3 complex subunits | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | TPR-like | 2 | 2 |  |
| F-box domain | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| FAD/NAD(P)-binding domain | Acetyl-CoA synthetase-like | 2 | 2 |  |
| PP2C-like | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | Actin-like ATPase domain | 2 | 2 |  |
| Tex N-terminal region-like | Nucleic acid-binding proteins | 2 | 2 |  |
| Creatinase/prolidase N-terminal domain | Creatinase/aminopeptidase | 2 | 2 |  |
| MOSC N-terminal domain-like | PK beta-barrel domain-like | 2 | 1 |  |
| PLP-dependent transferases | Ornithine decarboxylase C-terminal domain | 2 | 2 |  |
| Rhodanese/Cell cycle control phosphatase | alpha/beta-Hydrolases | 2 | 2 |  |
| DNA/RNA polymerases | WRKY DNA-binding domain | 2 | 2 |  |
| Class II aaRS and biotin synthetases | Translation proteins | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Pre-protein crosslinking domain of SecA | 2 | 2 |  |
| Metallo-hydrolase/oxidoreductase | SAM/Pointed domain | 2 | 2 |  |
| Tropomyosin | Tropomyosin | 2 | 2 |  |
| ARM repeat | FabD/lysophospholipase-like | 2 | 1 |  |
| Staphylococcal nuclease | Tudor/PWWP/MBT | 2 | 2 |  |
| 14-3-3 protein | 14-3-3 protein | 2 | 1 |  |
| Carbamate kinase-like | Acyl-CoA N-acyltransferases (Nat) | 2 | 2 |  |
| Pectin lyase-like | Thiolase-like | 2 | 2 |  |
| RING/U-box | EF-hand | 2 | 2 |  |
| Cysteine proteinases | Cysteine proteinases | 2 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | GHMP Kinase, C-terminal domain | 2 | 2 |  |
| L domain-like | Ubiquitin-like | 2 | 2 |  |
| "Winged helix" DNA-binding domain | HLH, helix-loop-helix DNA-binding domain | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Prokaryotic type KH domain (KH-domain type II) | 2 | 2 |  |
| Single hybrid motif | Single hybrid motif | 2 | 1 |  |
| Translation initiation factor IF3, N-terminal domain | Translation initiation factor IF3, C-terminal domain | 2 | 2 |  |
| (Trans)glycosidases | DNA/RNA polymerases | 2 | 2 |  |
| Ribonuclease H-like | (Trans)glycosidases | 2 | 2 |  |
| Ricin B-like lectins | Ricin B-like lectins | 2 | 2 |  |
| TPR-like | DNA/RNA polymerases | 2 | 2 |  |
| HMA, heavy metal-associated domain | Metal cation-transporting ATPase, ATP-binding domain N | 2 | 2 |  |
| PAZ domain | dsRNA-binding domain-like | 2 | 2 |  |
| Class I glutamine amidotransferase-like | GMP synthetase C-terminal dimerisation domain | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Sm-like ribonucleoproteins | 2 | 2 |  |
| Plus3-like | GYF domain | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Phosphoglycerate mutase-like | 2 | 1 |  |
| Amidase signature (AS) enzymes | TPR-like | 2 | 1 |  |
| Bet v1-like | Glucocorticoid receptor-like (DNA-binding domain) | 2 | 2 |  |
| alpha/beta-Hydrolases | CheY-like | 2 | 2 |  |
| Hypothetical protein TM0160 | CRAL/TRIO N-terminal domain | 2 | 1 |  |
| F-box domain | SET domain | 2 | 2 |  |
| Class II aaRS and biotin synthetases | Anticodon-binding domain of PheRS | 2 | 1 |  |
| Surp module (SWAP domain) | Ubiquitin-like | 2 | 1 |  |
| MFS general substrate transporter | Homeodomain-like | 2 | 2 |  |
| Class II aaRS ABD-related | C-terminal domain of ProRS | 2 | 2 |  |
| Nucleotide-diphospho-sugar transferases | RNA-binding domain, RBD | 2 | 1 |  |
| Macro domain-like | Zn-dependent exopeptidases | 2 | 2 |  |
| GYF domain | SET domain | 2 | 2 |  |
| PreATP-grasp domain | PreATP-grasp domain | 2 | 2 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | alpha/beta-Hydrolases | 2 | 2 |  |
| RING/U-box | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 2 | 2 |  |
| RNA-binding domain, RBD | Metallo-dependent phosphatases | 2 | 2 |  |
| Ubiquitin-like | HAD-like | 2 | 2 |  |
| Cyclophilin-like | TPR-like | 2 | 1 |  |
| Homeodomain-like | Protein kinase-like (PK-like) | 2 | 2 |  |
| Eukaryotic RPB5 N-terminal domain | RPB5-like RNA polymerase subunit | 2 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 2 | 2 |  |
| Rudiment single hybrid motif | Single hybrid motif | 2 | 2 |  |
| ARM repeat | WRKY DNA-binding domain | 2 | 2 |  |
| Quinoprotein alcohol dehydrogenase-like | Quinoprotein alcohol dehydrogenase-like | 2 | 2 |  |
| PreATP-grasp domain | ClpP/crotonase | 2 | 2 |  |
| Staphylococcal nuclease | Staphylococcal nuclease | 2 | 2 |  |
| Thioredoxin-like | ENT-like | 2 | 1 |  |
| DNA-binding domain | Thioredoxin-like | 2 | 2 |  |
| PUA domain-like | Ribosomal protein S5 domain 2-like | 2 | 2 |  |
| ARM repeat | MFS general substrate transporter | 2 | 2 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | L domain-like | 2 | 2 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | L domain-like | 2 | 2 |  |
| Diaminopimelate epimerase-like | Diaminopimelate epimerase-like | 2 | 2 |  |
| "Winged helix" DNA-binding domain | E set domains | 2 | 1 |  |
| Acid proteases | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| MurE/MurF N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 2 |  |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 2 | 2 |  |
| GroEL-intermediate domain like | GroEL-intermediate domain like | 2 | 2 |  |
| HIT/MYND zinc finger-like | Cysteine proteinases | 2 | 2 |  |
| BEACH domain | ARM repeat | 2 | 2 |  |
| ATP-dependent DNA ligase DNA-binding domain | DNA ligase/mRNA capping enzyme, catalytic domain | 2 | 2 |  |
| Galactose oxidase, central domain | Metallo-dependent phosphatases | 2 | 2 |  |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleic acid-binding proteins | 2 | 2 |  |
| EF-hand | Leucine zipper domain | 2 | 1 |  |
| Hypothetical protein SAV1430 | Fe-S cluster assembly (FSCA) domain-like | 2 | 1 |  |
| RING/U-box | "Winged helix" DNA-binding domain | 2 | 2 |  |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleotidylyl transferase | 2 | 2 |  |
| Calponin-homology domain, CH-domain | NAD(P)-binding Rossmann-fold domains | 2 | 1 |  |
| Tex N-terminal region-like | Ribonuclease H-like | 2 | 2 |  |
| Formin homology 2 domain (FH2 domain) | Ribonuclease H-like | 2 | 2 |  |
| Ribonuclease H-like | SH2 domain | 2 | 2 |  |
| Carbamate kinase-like | NAD(P)-binding Rossmann-fold domains | 2 | 2 |  |
| Bromodomain | Protein kinase-like (PK-like) | 2 | 2 |  |
| NAD(P)-linked oxidoreductase | NAD(P)-linked oxidoreductase | 2 | 2 |  |
| PreATP-grasp domain | N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 2 | 2 |  |
| HMG-box | HMG-box | 2 | 2 |  |
| (Trans)glycosidases | FAD-linked oxidases, C-terminal domain | 2 | 2 |  |
| PapD-like | PapD-like | 2 | 2 |  |
| (Trans)glycosidases | F-box domain | 2 | 2 |  |
| ARM repeat | RNA-binding domain, RBD | 2 | 2 |  |
| Ribonuclease H-like | Mannose-binding lectins | 2 | 2 |  |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 2 | 1 |  |
| Pentein | Nucleic acid-binding proteins | 2 | 1 |  |
| Second domain of FERM | Prismane protein-like | 2 | 2 |  |
| Ribonuclease H-like | ENTH/VHS domain | 2 | 2 |  |
| Myosin rod fragments | Tropomyosin | 2 | 2 |  |
| HAD-like | NHL repeat | 2 | 2 |  |
| Ribonuclease PH domain 2-like | Nucleic acid-binding proteins | 2 | 2 |  |
| ARM repeat | POZ domain | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Helical scaffold and wing domains of SecA | 2 | 2 |  |
| RNA-binding domain, RBD | Protein kinase-like (PK-like) | 2 | 2 |  |
| CBS-domain pair | Inosine monophosphate dehydrogenase (IMPDH) | 2 | 2 |  |
| SET domain | SET domain | 2 | 2 |  |
| Ribosomal protein L4 | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Zn-binding ribosomal proteins | 2 | 2 |  |
| RuvA domain 2-like | SH2 domain | 2 | 2 |  |
| UBA-like | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Concanavalin A-like lectins/glucanases | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Seven-hairpin glycosidases | Prefoldin | 2 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Single hybrid motif | 2 | 2 |  |
| Protein kinase-like (PK-like) | Clavaminate synthase-like | 2 | 2 |  |
| RNA-binding domain, RBD | TPR-like | 2 | 2 |  |
| RNA-binding domain, RBD | Multidrug resistance efflux transporter EmrE | 2 | 2 |  |
| Thioredoxin-like | ERP29 C domain-like | 2 | 1 |  |
| Galactose mutarotase-like | Starch-binding domain-like | 2 | 2 |  |
| cAMP-binding domain-like | cAMP-binding domain-like | 2 | 2 |  |
| HAND domain of the nucleosome remodeling ATPase ISWI | Homeodomain-like | 2 | 2 |  |
| RNI-like | Ribonuclease H-like | 2 | 2 |  |
| Aminoacid dehydrogenase-like, N-terminal domain | Aminoacid dehydrogenase-like, N-terminal domain | 2 | 2 |  |
| DNA-binding pseudobarrel domain | ssDNA-binding transcriptional regulator domain | 2 | 2 |  |
| PreATP-grasp domain | Single hybrid motif | 2 | 2 |  |
| ARM repeat | PH domain-like | 2 | 2 |  |
| Coproporphyrinogen III oxidase | Protein kinase-like (PK-like) | 2 | 2 |  |
| Outer arm dynein light chain 1 | Protein kinase-like (PK-like) | 2 | 2 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Protein kinase-like (PK-like) | 2 | 2 |  |
| BRCT domain | WGR domain-like | 2 | 2 |  |
| R1 subunit of ribonucleotide reductase, N-terminal domain | PFL-like glycyl radical enzymes | 2 | 1 |  |
| Ribonuclease H-like | Ubiquitin-like | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | CYTH-like phosphatases | 2 | 2 |  |
| Nucleotide-diphospho-sugar transferases | alpha/beta-Hydrolases | 2 | 2 |  |
| L9 N-domain-like | Ribosomal protein L9 C-domain | 2 | 2 |  |
| Trimeric LpxA-like enzymes | Trimeric LpxA-like enzymes | 2 | 2 |  |
| tRNA-binding arm | Class II aaRS and biotin synthetases | 2 | 2 |  |
| Cytochrome P450 | Histidine-containing phosphotransfer domain, HPT domain | 2 | 2 |  |
| NAC domain | RING/U-box | 2 | 2 |  |
| Cap-Gly domain | Ubiquitin-like | 2 | 2 |  |
| Translational machinery components | Translational machinery components | 2 | 2 |  |
| Ribonuclease H-like | F-box domain | 2 | 2 |  |
| alpha/beta-Hydrolases | Homeodomain-like | 2 | 2 |  |
| Nucleic acid-binding proteins | eIF2alpha middle domain-like | 2 | 1 |  |
| Acyl-CoA binding protein | Ankyrin repeat | 2 | 2 |  |
| Tex N-terminal region-like | SH2 domain | 2 | 2 |  |
| PH domain-like | WD40 repeat-like | 2 | 2 |  |
| Ubiquitin-like | Hect, E3 ligase catalytic domain | 2 | 2 |  |
| Ribonuclease H-like | MFS general substrate transporter | 2 | 2 |  |
| RING/U-box | UBA-like | 2 | 2 |  |
| RuvA domain 2-like | Nucleic acid-binding proteins | 2 | 2 |  |
| Ubiquitin-like | ARM repeat | 2 | 1 |  |
| Arabinanase/levansucrase/invertase | Arabinanase/levansucrase/invertase | 2 | 2 |  |
| BRCT domain | ADP-ribosylation | 2 | 2 |  |
| ALDH-like | DNA/RNA polymerases | 2 | 2 |  |
| Actin-crosslinking proteins | Actin-crosslinking proteins | 2 | 2 |  |
| F-box domain | LysM domain | 2 | 1 |  |
| ThrRS/AlaRS common domain | Class II aaRS ABD-related | 2 | 2 |  |
| DNA/RNA polymerases | Preprotein translocase SecY subunit | 2 | 2 |  |
| L domain-like | HSP20-like chaperones | 2 | 2 |  |
| "Winged helix" DNA-binding domain | Sec63 N-terminal domain-like | 2 | 1 |  |
| Protein kinase-like (PK-like) | E set domains | 2 | 2 |  |
| Ribonuclease H-like | RuvA domain 2-like | 2 | 2 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | FAD-binding/transporter-associated domain-like | 2 | 2 |  |
| Protein kinase-like (PK-like) | Nucleotidylyl transferase | 2 | 2 |  |
| Translation proteins | ThrRS/AlaRS common domain | 2 | 2 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | FAD-linked oxidases, C-terminal domain | 2 | 2 |  |
| Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 2 | 1 |  |
| RING/U-box | Cyclophilin-like | 2 | 2 |  |
| Ubiquitin-like | DNA/RNA polymerases | 2 | 2 |  |
| Tubulin nucleotide-binding domain-like | Tubulin nucleotide-binding domain-like | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | FAS1 domain | 2 | 2 |  |
| Pre-protein crosslinking domain of SecA | Helical scaffold and wing domains of SecA | 2 | 2 |  |
| HD-domain/PDEase-like | TGS-like | 2 | 2 |  |
| SNARE-like | SNARE-like | 2 | 2 |  |
| Class I glutamine amidotransferase-like | Adenine nucleotide alpha hydrolases-like | 2 | 2 |  |
| Cytidine deaminase-like | Dihydrofolate reductase-like | 2 | 2 |  |
| Ribonuclease PH domain 2-like | Ribonuclease PH domain 2-like | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | alpha/beta-Hydrolases | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | Succinyl-CoA synthetase domains | 2 | 2 |  |
| CCCH zinc finger | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 2 |  |
| MurE/MurF N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 2 |  |
| Nucleic acid-binding proteins | Homeodomain-like | 2 | 2 |  |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | RNA-binding domain, RBD | 2 | 2 |  |
| Leukotriene A4 hydrolase N-terminal domain | ARM repeat | 2 | 2 |  |
| UBC-like | DNA-binding domain | 2 | 2 |  |
| Hypothetical protein TM0160 | CRAL/TRIO domain | 2 | 1 |  |
| Ubiquitin-like | PUG domain-like | 2 | 2 |  |
| F-box domain | L domain-like | 2 | 2 |  |
| beta-Galactosidase/glucuronidase domain | (Trans)glycosidases | 2 | 2 |  |
| PRP4-like | Functional domain of the splicing factor Prp18 | 2 | 2 |  |
| Clavaminate synthase-like | DNA/RNA polymerases | 2 | 2 |  |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | S13-like H2TH domain | 2 | 2 |  |
| C-terminal, gelsolin-like domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 2 | 2 |  |
| L domain-like | RING/U-box | 2 | 2 |  |
| alpha/beta-Hydrolases | Riboflavin synthase domain-like | 2 | 2 |  |
| Acetyl-CoA synthetase-like | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 2 | 2 |  |
| Eukaryotic type KH-domain (KH-domain type I) | RNA-binding domain, RBD | 2 | 2 |  |
| Protein kinase-like (PK-like) | RmlC-like cupins | 2 | 2 |  |
| E2F-DP heterodimerization region | E2F-DP heterodimerization region | 2 | 2 |  |
| F-box domain | Actin-like ATPase domain | 2 | 2 |  |
| Concanavalin A-like lectins/glucanases | HMA, heavy metal-associated domain | 2 | 2 |  |
| Alpha-L RNA-binding motif | Pseudouridine synthase | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | WD40 repeat-like | 2 | 2 |  |
| Six-hairpin glycosidases | Six-hairpin glycosidases | 2 | 2 |  |
| Folate-binding domain | Aminomethyltransferase beta-barrel domain | 2 | 2 |  |
| WD40 repeat-like | DNA/RNA polymerases | 2 | 2 |  |
| DEK C-terminal domain | SWIB/MDM2 domain | 2 | 2 |  |
| Ribokinase-like | Ribokinase-like | 2 | 1 |  |
| PurM N-terminal domain-like | PurM C-terminal domain-like | 2 | 2 |  |
| L domain-like | FabD/lysophospholipase-like | 2 | 1 |  |
| Chaperone J-domain | Thioredoxin-like | 2 | 2 |  |
| Phosphoglycerate mutase-like | Phosphoglycerate mutase-like | 2 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Formin homology 2 domain (FH2 domain) | 2 | 2 |  |
| PH domain-like | BEACH domain | 2 | 2 |  |
| Carbamate kinase-like | ALDH-like | 2 | 2 |  |
| NAC domain | ENTH/VHS domain | 2 | 2 |  |
| SH2 domain | SH2 domain | 2 | 2 |  |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 2 | 2 |  |
| Nqo1 middle domain-like | Nqo1C-terminal domain-like | 2 | 2 |  |
| RNA-binding domain, RBD | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 2 |  |
| Ribonuclease H-like | HRDC-like | 2 | 2 |  |
| Nucleic acid-binding proteins | SH2 domain | 2 | 2 |  |
| ALDH-like | ALDH-like | 2 | 2 |  |
| Terpenoid cyclases/Protein prenyltransferases | Cytochrome P450 | 2 | 2 |  |
| Metalloproteases ("zincins"), catalytic domain | ARM repeat | 2 | 2 |  |
| Tex N-terminal region-like | RuvA domain 2-like | 2 | 2 |  |
| DNA clamp | DNA clamp | 2 | 2 |  |
| Leucine zipper domain | AlbA-like | 2 | 2 |  |
| ARM repeat | Glucocorticoid receptor-like (DNA-binding domain) | 2 | 2 |  |
| Chromo domain-like | Homeodomain-like | 2 | 1 |  |
| Calponin-homology domain, CH-domain | Calponin-homology domain, CH-domain | 2 | 2 |  |
| RING/U-box | TPR-like | 2 | 2 |  |
| ACT-like | Protein kinase-like (PK-like) | 2 | 2 |  |
| Sec63 N-terminal domain-like | Sec63 N-terminal domain-like | 2 | 1 |  |
| Ubiquitin-like | TPR-like | 2 | 2 |  |
| Adenine nucleotide alpha hydrolases-like | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Second domain of FERM | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Homeodomain-like | RNA-binding domain, RBD | 2 | 2 |  |
| ACT-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 2 | 2 |  |
| 4Fe-4S ferredoxins | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| PDZ domain-like | TPR-like | 2 | 2 |  |
| Nucleotidylyl transferase | Ribosomal protein L25-like | 2 | 2 |  |
| Galactose-binding domain-like | beta-Galactosidase/glucuronidase domain | 2 | 2 |  |
| FAD/NAD(P)-binding domain | Thioredoxin-like | 2 | 2 |  |
| F-box domain | Ankyrin repeat | 2 | 2 |  |
| Dimeric alpha+beta barrel | Dimeric alpha+beta barrel | 2 | 1 |  |
| BAG domain | ARM repeat | 2 | 1 |  |
| SSo0622-like | Kelch motif | 1 | 1 |  |
| E set domains | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | HCP-like | 1 | 1 |  |
| NSFL1 (p97 ATPase) cofactor p47, SEP domain | TPR-like | 1 | 1 |  |
| Clathrin heavy-chain terminal domain | Clathrin heavy-chain terminal domain | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Allene oxide cyclase-like | 1 | 1 |  |
| ATP12-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| Cap-Gly domain | L domain-like | 1 | 1 |  |
| HMG-box | WRKY DNA-binding domain | 1 | 1 |  |
| NTF2-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Bromodomain | Ribonuclease H-like | 1 | 1 |  |
| alpha/beta-Hydrolases | Cyclin-like | 1 | 1 |  |
| FMN-linked oxidoreductases | Acetyl-CoA synthetase-like | 1 | 1 |  |
| Chelatase | Ubiquitin-like | 1 | 1 |  |
| SRF-like | SRF-like | 1 | 1 |  |
| Actin-like ATPase domain | GroEL equatorial domain-like | 1 | 1 |  |
| Phosphoglycerate mutase-like | FKBP-like | 1 | 1 |  |
| Preprotein translocase SecY subunit | E set domains | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | EF-hand | 1 | 1 |  |
| NTF2-like | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 1 | 1 |  |
| Nucleic acid-binding proteins | alpha/beta-Hydrolases | 1 | 1 |  |
| Type II DNA topoisomerase | F-box domain | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| DEK C-terminal domain | Histone-fold | 1 | 1 |  |
| RING/U-box | ArfGap/RecO-like zinc finger | 1 | 1 |  |
| Protein kinase-like (PK-like) | RplX-like | 1 | 1 |  |
| L domain-like | HD-domain/PDEase-like | 1 | 1 |  |
| EreA/ChaN-like | alpha-D-mannose-specific plant lectins | 1 | 1 |  |
| UBC-like | Formate/glycerate dehydrogenase catalytic domain-like | 1 | 1 |  |
| Barwin-like endoglucanases | Ribosomal protein S18 | 1 | 1 |  |
| Leucine zipper domain | Thiamin diphosphate-binding fold (THDP-binding) | 1 | 1 |  |
| ARM repeat | UBC-like | 1 | 1 |  |
| beta-lactamase/transpeptidase-like | Tautomerase/MIF | 1 | 1 |  |
| S-adenosylmethionine synthetase | Pectin lyase-like | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Cupredoxins | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Osmotin, thaumatin-like protein | 1 | 1 |  |
| Nop domain | ARM repeat | 1 | 1 |  |
| Tudor/PWWP/MBT | Multidrug resistance efflux transporter EmrE | 1 | 1 |  |
| PAZ domain | F1F0 ATP synthase subunit C | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | Domain of poly(ADP-ribose) polymerase | 1 | 1 |  |
| Chaperone J-domain | Arginase/deacetylase | 1 | 1 |  |
| Rhodanese/Cell cycle control phosphatase | Actin-like ATPase domain | 1 | 1 |  |
| dsRNA-binding domain-like | HSP20-like chaperones | 1 | 1 |  |
| CCCH zinc finger | HIT-like | 1 | 1 |  |
| ARM repeat | Cyclin-like | 1 | 1 |  |
| DNA-glycosylase | Nudix | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Obg GTP-binding protein C-terminal domain | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | DNA clamp | 1 | 1 |  |
| Ribosomal protein L16p/L10e | RING/U-box | 1 | 1 |  |
| Composite domain of metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Putative methyltransferase TM0872, insert domain | 1 | 1 |  |
| ARM repeat | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) | 1 | 1 |  |
| P-domain of calnexin/calreticulin | Leucine zipper domain | 1 | 1 |  |
| POZ domain | Pentapeptide repeat-like | 1 | 1 |  |
| Carbamate kinase-like | Carbamate kinase-like | 1 | 1 |  |
| t-snare proteins | EF-G C-terminal domain-like | 1 | 1 |  |
| Ribonuclease H-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | FAD/NAD(P)-binding domain | 1 | 1 |  |
| EF-hand | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
| Calcium ATPase, transduction domain A | (Trans)glycosidases | 1 | 1 |  |
| RNI-like | Histone-fold | 1 | 1 |  |
| FGAM synthase PurL, linker domain | Class I glutamine amidotransferase-like | 1 | 1 |  |
| Acyl-CoA dehydrogenase NM domain-like | Thioredoxin-like | 1 | 1 |  |
| Enolase N-terminal domain-like | alpha/beta-Hydrolases | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Ribonuclease H-like | 1 | 1 |  |
| UBC-like | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
| UBC-like | HSP40/DnaJ peptide-binding domain | 1 | 1 |  |
| Class II aaRS and biotin synthetases | Homeodomain-like | 1 | 1 |  |
| Ankyrin repeat | Ran binding protein zinc finger-like | 1 | 1 |  |
| "Winged helix" DNA-binding domain | Ankyrin repeat | 1 | 1 |  |
| Ribosomal proteins S24e, L23 and L15e | Chaperone J-domain | 1 | 1 |  |
| FAD/NAD(P)-binding domain | SBT domain | 1 | 1 |  |
| Class II aaRS and biotin synthetases | Mog1p/PsbP-like | 1 | 1 |  |
| PUA domain-like | PUA domain-like | 1 | 1 |  |
| Chaperone J-domain | CSL zinc finger | 1 | 1 |  |
| WD40 repeat-like | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | FYVE/PHD zinc finger | 1 | 1 |  |
| Ribonuclease H-like | Cysteine proteinases | 1 | 1 |  |
| Translation proteins | PP2C-like | 1 | 1 |  |
| FAS1 domain | Ribonuclease H-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Calcium-dependent phosphotriesterase | 1 | 1 |  |
| Retrovirus zinc finger-like domains | PX domain | 1 | 1 |  |
| Ubiquitin-like | (Trans)glycosidases | 1 | 1 |  |
| AlbA-like | GST C-terminal domain-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | RuvA domain 2-like | 1 | 1 |  |
| alpha-D-mannose-specific plant lectins | RplX-like | 1 | 1 |  |
| Homeodomain-like | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| Cyclophilin-like | HSP40/DnaJ peptide-binding domain | 1 | 1 |  |
| Acid proteases | WRKY DNA-binding domain | 1 | 1 |  |
| (Trans)glycosidases | CBS-domain pair | 1 | 1 |  |
| PDZ domain-like | E set domains | 1 | 1 |  |
| SAP domain | F-box domain | 1 | 1 |  |
| Galactose mutarotase-like | Galactose mutarotase-like | 1 | 1 |  |
| Arabinanase/levansucrase/invertase | TPR-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Nucleotidyltransferase | 1 | 1 |  |
| cAMP-binding domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| PA domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| TPR-like | Glycerol-3-phosphate (1)-acyltransferase | 1 | 1 |  |
| Formin homology 2 domain (FH2 domain) | CBS-domain pair | 1 | 1 |  |
| t-snare proteins | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Glycerol-3-phosphate (1)-acyltransferase | MFS general substrate transporter | 1 | 1 |  |
| DNA/RNA polymerases | Seven-hairpin glycosidases | 1 | 1 |  |
| Chaperone J-domain | alpha/beta knot | 1 | 1 |  |
| Nucleotidyltransferase | Protein kinase-like (PK-like) | 1 | 1 |  |
| Protein kinase-like (PK-like) | Trimeric LpxA-like enzymes | 1 | 1 |  |
| Thioredoxin-like | Homeodomain-like | 1 | 1 |  |
| Heme-dependent peroxidases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| Protein kinase-like (PK-like) | Acyl-CoA dehydrogenase C-terminal domain-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | LexA/Signal peptidase | 1 | 1 |  |
| alpha/beta-Hydrolases | (Trans)glycosidases | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | NAP-like | 1 | 1 |  |
| L domain-like | FMN-linked oxidoreductases | 1 | 1 |  |
| alpha-D-mannose-specific plant lectins | Rhomboid-like | 1 | 1 |  |
| Periplasmic binding protein-like II | Ubiquitin-like | 1 | 1 |  |
| C-terminal, gelsolin-like domain of Sec23/24 | (Trans)glycosidases | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | BEACH domain | 1 | 1 |  |
| Ypt/Rab-GAP domain of gyp1p | DNA/RNA polymerases | 1 | 1 |  |
| Actin-like ATPase domain | Beta-D-glucan exohydrolase, C-terminal domain | 1 | 1 |  |
| HAD-like | NTF2-like | 1 | 1 |  |
| Radical SAM enzymes | Radical SAM enzymes | 1 | 1 |  |
| Phosphoenolpyruvate/pyruvate domain | HMA, heavy metal-associated domain | 1 | 1 |  |
| alpha/beta-Hydrolases | DNase I-like | 1 | 1 |  |
| MurD-like peptide ligases, catalytic domain | JAB1/MPN domain | 1 | 1 |  |
| Lipocalins | Lipocalins | 1 | 1 |  |
| GroEL apical domain-like | Mitochondrial carrier | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | Nucleic acid-binding proteins | 1 | 1 |  |
| Metallo-dependent phosphatases | DNA-binding domain | 1 | 1 |  |
| BRCT domain | Acid proteases | 1 | 1 |  |
| Plant invertase/pectin methylesterase inhibitor | Ran binding protein zinc finger-like | 1 | 1 |  |
| CoA-dependent acyltransferases | Acid proteases | 1 | 1 |  |
| Mss4-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| Thioredoxin-like | Cytochrome P450 | 1 | 1 |  |
| MFS general substrate transporter | Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | 1 |  |
| SRF-like | TPR-like | 1 | 1 |  |
| HMA, heavy metal-associated domain | PHP domain-like | 1 | 1 |  |
| Kelch motif | AlbA-like | 1 | 1 |  |
| Amidase signature (AS) enzymes | Ribonuclease H-like | 1 | 1 |  |
| Homeodomain-like | Multidrug resistance efflux transporter EmrE | 1 | 1 |  |
| Hect, E3 ligase catalytic domain | Hect, E3 ligase catalytic domain | 1 | 1 |  |
| Riboflavin synthase domain-like | MFS general substrate transporter | 1 | 1 |  |
| SAP domain | Domain of poly(ADP-ribose) polymerase | 1 | 1 |  |
| Subtilisin-like | Subtilisin-like | 1 | 1 |  |
| FAD-linked reductases, C-terminal domain | FMN-binding split barrel | 1 | 1 |  |
| DNA/RNA polymerases | NTF2-like | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | Cryptochrome/photolyase, N-terminal domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | DLC | 1 | 1 |  |
| DNA/RNA polymerases | Carbamate kinase-like | 1 | 1 |  |
| PHL pollen allergen | Protein kinase-like (PK-like) | 1 | 1 |  |
| RNA-binding domain, RBD | GST C-terminal domain-like | 1 | 1 |  |
| Osmotin, thaumatin-like protein | Osmotin, thaumatin-like protein | 1 | 1 |  |
| BEACH domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | DNA mismatch repair protein MutL | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
| MAL13P1.257-like | Zn-dependent exopeptidases | 1 | 1 |  |
| RING/U-box | F-box domain | 1 | 1 |  |
| TPR-like | MFS general substrate transporter | 1 | 1 |  |
| Tudor/PWWP/MBT | RNA-binding domain, RBD | 1 | 1 |  |
| FKBP-like | Triger factor/SurA peptide-binding domain-like | 1 | 1 |  |
| Translation proteins | PRC-barrel domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| Acid proteases | Fe-only hydrogenase | 1 | 1 |  |
| Protein kinase-like (PK-like) | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| Chaperone J-domain | Ribulose-phoshate binding barrel | 1 | 1 |  |
| Protein kinase-like (PK-like) | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| ENT-like | ENT-like | 1 | 1 |  |
| Ribonuclease H-like | Glutamine synthetase/guanido kinase | 1 | 1 |  |
| CBS-domain pair | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Amine oxidase N-terminal region | Thiamin diphosphate-binding fold (THDP-binding) | 1 | 1 |  |
| SRF-like | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 |  |
| LexA/Signal peptidase | Clavaminate synthase-like | 1 | 1 |  |
| Thioredoxin-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| EF-hand | MFS general substrate transporter | 1 | 1 |  |
| Heme-dependent peroxidases | CAD & PB1 domains | 1 | 1 |  |
| NTF2-like | Probable bacterial effector-binding domain | 1 | 1 |  |
| WD40 repeat-like | Calcium-dependent phosphotriesterase | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Calcium ATPase, transduction domain A | 1 | 1 |  |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 1 | 1 |  |
| Pectin lyase-like | Smc hinge domain | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | PK beta-barrel domain-like | 1 | 1 |  |
| alpha/beta-Hydrolases | Saposin | 1 | 1 |  |
| Six-hairpin glycosidases | TPR-like | 1 | 1 |  |
| DNA/RNA polymerases | HAD-like | 1 | 1 |  |
| FMN-dependent nitroreductase-like | FMN-dependent nitroreductase-like | 1 | 1 |  |
| Creatinase/aminopeptidase | NAD(P)-linked oxidoreductase | 1 | 1 |  |
| Subtilisin-like | Osmotin, thaumatin-like protein | 1 | 1 |  |
| Thioredoxin-like | Nqo1 FMN-binding domain-like | 1 | 1 |  |
| GroEL-intermediate domain like | Cysteine proteinases | 1 | 1 |  |
| PAZ domain | PAZ domain | 1 | 1 |  |
| Glutamine synthetase/guanido kinase | GatB/YqeY motif | 1 | 1 |  |
| NAC domain | PP2C-like | 1 | 1 |  |
| Periplasmic binding protein-like II | WD40 repeat-like | 1 | 1 |  |
| Tropomyosin | Thioesterase/thiol ester dehydrase-isomerase | 1 | 1 |  |
| PP2C-like | Coiled-coil domain of nucleotide exchange factor GrpE | 1 | 1 |  |
| UBA-like | TPR-like | 1 | 1 |  |
| Ankyrin repeat | Acid proteases | 1 | 1 |  |
| Protein kinase-like (PK-like) | CoaB-like | 1 | 1 |  |
| Zn-finger domain of Sec23/24 | ARM repeat | 1 | 1 |  |
| PUA domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| AlbA-like | Release factor | 1 | 1 |  |
| RNA-binding domain, RBD | alpha/beta-Hydrolases | 1 | 1 |  |
| "Winged helix" DNA-binding domain | Pectin lyase-like | 1 | 1 |  |
| GroEL equatorial domain-like | Galactose mutarotase-like | 1 | 1 |  |
| Sec63 N-terminal domain-like | DNA/RNA polymerases | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | GroEL equatorial domain-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Mitochondrial carrier | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | ATP-dependent DNA ligase DNA-binding domain | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Thiolase-like | RING/U-box | 1 | 1 |  |
| Nucleic acid-binding proteins | Ribosomal protein S3 C-terminal domain | 1 | 1 |  |
| Cyclophilin-like | PP2C-like | 1 | 1 |  |
| Mitochondrial carrier | Cytochrome P450 | 1 | 1 |  |
| RmlC-like cupins | ARM repeat | 1 | 1 |  |
| Clavaminate synthase-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| GroES-like | Mitochondrial carrier | 1 | 1 |  |
| Subdomain of clathrin and coatomer appendage domain | Subdomain of clathrin and coatomer appendage domain | 1 | 1 |  |
| Double Clp-N motif | Taf5 N-terminal domain-like | 1 | 1 |  |
| ENTH/VHS domain | ENTH/VHS domain | 1 | 1 |  |
| Heme oxygenase-like | Heme oxygenase-like | 1 | 1 |  |
| Rap30/74 interaction domains | Rap30/74 interaction domains | 1 | 1 |  |
| L domain-like | Nucleic acid-binding proteins | 1 | 1 |  |
| Tudor/PWWP/MBT | DNA repair protein MutS, domain I | 1 | 1 |  |
| Succinyl-CoA synthetase domains | Pectin lyase-like | 1 | 1 |  |
| Urease, gamma-subunit | Metallo-dependent hydrolases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Bromodomain | alpha/beta-Hydrolases | 1 | 1 |  |
| AF0104/ALDC/Ptd012-like | RING/U-box | 1 | 1 |  |
| Cullin repeat-like | Terpenoid synthases | 1 | 1 |  |
| HAD-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | LuxS/MPP-like metallohydrolase | 1 | 1 |  |
| RNA-binding domain, RBD | beta-sandwich domain of Sec23/24 | 1 | 1 |  |
| Alpha-L RNA-binding motif | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Chlorophyll a-b binding protein | FMN-linked oxidoreductases | 1 | 1 |  |
| Restriction endonuclease-like | RuvA domain 2-like | 1 | 1 |  |
| HAD-like | (Trans)glycosidases | 1 | 1 |  |
| HSP20-like chaperones | LEA14-like | 1 | 1 |  |
| WD40 repeat-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | 1 |  |
| t-snare proteins | Translation proteins | 1 | 1 |  |
| UBC-like | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 1 | 1 |  |
| SMAD/FHA domain | BRCT domain | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| Zn-dependent exopeptidases | Translational machinery components | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | GroES-like | 1 | 1 |  |
| FAD-linked reductases, C-terminal domain | SBT domain | 1 | 1 |  |
| TGS-like | ThrRS/AlaRS common domain | 1 | 1 |  |
| PLP-dependent transferases | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 1 | 1 |  |
| JAB1/MPN domain | HCP-like | 1 | 1 |  |
| Bromodomain | Chromo domain-like | 1 | 1 |  |
| Eukaryotic type KH-domain (KH-domain type I) | (Trans)glycosidases | 1 | 1 |  |
| ClpP/crotonase | ClpS-like | 1 | 1 |  |
| BRCT domain | DNA polymerase beta, N-terminal domain-like | 1 | 1 |  |
| FYVE/PHD zinc finger | SWIB/MDM2 domain | 1 | 1 |  |
| PsbU/PolX domain-like | Nucleotidyltransferase | 1 | 1 |  |
| Ran binding protein zinc finger-like | AlbA-like | 1 | 1 |  |
| PRC-barrel domain | PRC-barrel domain | 1 | 1 |  |
| GroEL apical domain-like | GroEL apical domain-like | 1 | 1 |  |
| RING/U-box | Leucine zipper domain | 1 | 1 |  |
| Translation proteins SH3-like domain | WRKY DNA-binding domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | HIT/MYND zinc finger-like | 1 | 1 |  |
| Cyclophilin-like | Chaperone J-domain | 1 | 1 |  |
| Ankyrin repeat | GroEL equatorial domain-like | 1 | 1 |  |
| ARM repeat | Ribosomal protein L32e | 1 | 1 |  |
| EF-hand | DNA-binding domain of EIN3-like | 1 | 1 |  |
| Cysteine proteinases | TAZ domain | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | HCP-like | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Homeodomain-like | 1 | 1 |  |
| F-box domain | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| Periplasmic binding protein-like II | Voltage-gated potassium channels | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | E set domains | 1 | 1 |  |
| TGS-like | Class II aaRS and biotin synthetases | 1 | 1 |  |
| Class II aaRS and biotin synthetases | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Carbon-nitrogen hydrolase | 1 | 1 |  |
| RNA-binding domain, RBD | Ankyrin repeat | 1 | 1 |  |
| CRAL/TRIO N-terminal domain | PUA domain-like | 1 | 1 |  |
| Pre-PUA domain | PUA domain-like | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| FAD-linked oxidases, C-terminal domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | ARM repeat | 1 | 1 |  |
| Prokaryotic type KH domain (KH-domain type II) | (Trans)glycosidases | 1 | 1 |  |
| SNARE-like | DNase I-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | HSP20-like chaperones | 1 | 1 |  |
| HSP40/DnaJ peptide-binding domain | HSC20 (HSCB), C-terminal oligomerisation domain | 1 | 1 |  |
| RNI-like | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | RplX-like | 1 | 1 |  |
| UBC-like | Chaperone J-domain | 1 | 1 |  |
| vWA-like | ARM repeat | 1 | 1 |  |
| (Trans)glycosidases | MurD-like peptide ligases, catalytic domain | 1 | 1 |  |
| Thioredoxin-like | HMA, heavy metal-associated domain | 1 | 1 |  |
| F-box domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 |  |
| PIN domain-like | C-terminal autoproteolytic domain of nucleoporin nup98 | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| lambda repressor-like DNA-binding domains | Cyanase C-terminal domain | 1 | 1 |  |
| SMAD/FHA domain | Aldolase | 1 | 1 |  |
| Homeodomain-like | WD40 repeat-like | 1 | 1 |  |
| CRAL/TRIO domain | Sec1/munc18-like (SM) proteins | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | NAD kinase/diacylglycerol kinase-like | 1 | 1 |  |
| CheY-like | TPR-like | 1 | 1 |  |
| C-terminal, gelsolin-like domain of Sec23/24 | ARM repeat | 1 | 1 |  |
| WRKY DNA-binding domain | DNA-binding pseudobarrel domain | 1 | 1 |  |
| GroEL apical domain-like | RING/U-box | 1 | 1 |  |
| Chitinase insertion domain | DNA/RNA polymerases | 1 | 1 |  |
| UBC-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Oxysterol-binding protein-like | Ubiquitin-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 |  |
| CCCH zinc finger | DNA/RNA polymerases | 1 | 1 |  |
| Formyltransferase | DNA/RNA polymerases | 1 | 1 |  |
| CBS-domain pair | RNA-binding domain, RBD | 1 | 1 |  |
| Translation proteins | Sm-like ribonucleoproteins | 1 | 1 |  |
| FAD/NAD(P)-binding domain | F-box domain | 1 | 1 |  |
| Histone-fold | PLP-dependent transferases | 1 | 1 |  |
| Arabinanase/levansucrase/invertase | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Single hybrid motif | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | PP2C-like | 1 | 1 |  |
| ARM repeat | Ribonuclease H-like | 1 | 1 |  |
| GAF domain-like | CAD & PB1 domains | 1 | 1 |  |
| RmlC-like cupins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| RNI-like | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| DNA-binding domain | Clavaminate synthase-like | 1 | 1 |  |
| Mitochondrial carrier | HMA, heavy metal-associated domain | 1 | 1 |  |
| Creatinase/aminopeptidase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Calpain large subunit, middle domain (domain III) | 1 | 1 |  |
| Inorganic pyrophosphatase | RNA-binding domain, RBD | 1 | 1 |  |
| TPR-like | ADP-ribosylation | 1 | 1 |  |
| alpha/beta-Hydrolases | Nucleotidylyl transferase | 1 | 1 |  |
| Cytochrome b5-like heme/steroid binding domain | PP2C-like | 1 | 1 |  |
| Actin-like ATPase domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| PLC-like phosphodiesterases | beta-beta-alpha zinc fingers | 1 | 1 |  |
| BAR/IMD domain-like | BAR/IMD domain-like | 1 | 1 |  |
| RNA-binding domain, RBD | Surp module (SWAP domain) | 1 | 1 |  |
| Ankyrin repeat | GroEL apical domain-like | 1 | 1 |  |
| AMMECR1-like | AMMECR1-like | 1 | 1 |  |
| Expressed protein At2g23090/F21P24.15 | Expressed protein At2g23090/F21P24.15 | 1 | 1 |  |
| DNA/RNA polymerases | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| F-box domain | ClpP/crotonase | 1 | 1 |  |
| AlbA-like | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| PIN domain-like | PIN domain-like | 1 | 1 |  |
| Cytochrome P450 | alpha/beta-Hydrolases | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | Cryptochrome/photolyase FAD-binding domain | 1 | 1 |  |
| RNA-binding domain, RBD | Saposin | 1 | 1 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | Nucleotide-binding domain | 1 | 1 |  |
| PSPTO4464-like | Osmotin, thaumatin-like protein | 1 | 1 |  |
| Zinc beta-ribbon | Myosin rod fragments | 1 | 1 |  |
| TRAF domain-like | Ubiquitin-like | 1 | 1 |  |
| Acid proteases | HAD-like | 1 | 1 |  |
| POZ domain | Galactose-binding domain-like | 1 | 1 |  |
| FMN-linked oxidoreductases | FMN-linked oxidoreductases | 1 | 1 |  |
| Amidase signature (AS) enzymes | Amidase signature (AS) enzymes | 1 | 1 |  |
| FAD-linked oxidoreductase | SNARE-like | 1 | 1 |  |
| Cysteine-rich domain | RING/U-box | 1 | 1 |  |
| HisI-like | all-alpha NTP pyrophosphatases | 1 | 1 |  |
| Acid proteases | UBA-like | 1 | 1 |  |
| Actin-like ATPase domain | HD-domain/PDEase-like | 1 | 1 |  |
| Acetyl-CoA synthetase-like | L domain-like | 1 | 1 |  |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 1 | 1 |  |
| Homeodomain-like | Mannose 6-phosphate receptor domain | 1 | 1 |  |
| FAS1 domain | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| POZ domain | L domain-like | 1 | 1 |  |
| RuBisCo LSMT C-terminal, substrate-binding domain | RNA-binding domain, RBD | 1 | 1 |  |
| Double Clp-N motif | Chaperone J-domain | 1 | 1 |  |
| NAD-binding domain of HMG-CoA reductase | NAD-binding domain of HMG-CoA reductase | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | Creatinase/aminopeptidase | 1 | 1 |  |
| MFS general substrate transporter | Cysteine proteinases | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Cysteine proteinases | 1 | 1 |  |
| Periplasmic binding protein-like II | GlnB-like | 1 | 1 |  |
| R3H domain | Ankyrin repeat | 1 | 1 |  |
| Cryptochrome/photolyase FAD-binding domain | Cryptochrome/photolyase FAD-binding domain | 1 | 1 |  |
| vWA-like | Homeodomain-like | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | Phospholipase D/nuclease | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | WRKY DNA-binding domain | 1 | 1 |  |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | DNA/RNA polymerases | 1 | 1 |  |
| Nucleic acid-binding proteins | Mog1p/PsbP-like | 1 | 1 |  |
| RNA-binding domain, RBD | DNA-binding pseudobarrel domain | 1 | 1 |  |
| Growth factor receptor domain | Growth factor receptor domain | 1 | 1 |  |
| DNA ligase/mRNA capping enzyme, catalytic domain | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| UBC-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | 1 |  |
| RNI-like | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Eukaryotic type KH-domain (KH-domain type I) | NAC domain | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | ARM repeat | 1 | 1 |  |
| PLP-binding barrel | Dihydrofolate reductase-like | 1 | 1 |  |
| Enolase C-terminal domain-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Calponin-homology domain, CH-domain | ARM repeat | 1 | 1 |  |
| HSP20-like chaperones | beta-beta-alpha zinc fingers | 1 | 1 |  |
| ARM repeat | Chlorophyll a-b binding protein | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 |  |
| DNA/RNA polymerases | RING/U-box | 1 | 1 |  |
| Plant invertase/pectin methylesterase inhibitor | RNA-binding domain, RBD | 1 | 1 |  |
| DNA-binding pseudobarrel domain | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| Fe-S cluster assembly (FSCA) domain-like | PLP-dependent transferases | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Clc chloride channel | 1 | 1 |  |
| Acyl-CoA dehydrogenase C-terminal domain-like | Thioredoxin-like | 1 | 1 |  |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | YVTN repeat-like/Quinoprotein amine dehydrogenase | 1 | 1 |  |
| CAD & PB1 domains | Pectin lyase-like | 1 | 1 |  |
| PLC-like phosphodiesterases | Thiamin diphosphate-binding fold (THDP-binding) | 1 | 1 |  |
| Ankyrin repeat | GroEL-intermediate domain like | 1 | 1 |  |
| PLP-dependent transferases | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| HMA, heavy metal-associated domain | Cu,Zn superoxide dismutase-like | 1 | 1 |  |
| SNARE-like | PH domain-like | 1 | 1 |  |
| Heme oxygenase-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Cyclin-like | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Pectin lyase-like | 1 | 1 |  |
| C-terminal domain of adenylylcyclase associated protein | (Trans)glycosidases | 1 | 1 |  |
| AlbA-like | TPR-like | 1 | 1 |  |
| LexA/Signal peptidase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| C-type lectin-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| ACP-like | Heme-dependent catalase-like | 1 | 1 |  |
| Substrate-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 1 | 1 |  |
| Ammonium transporter | Ribonuclease H-like | 1 | 1 |  |
| PreATP-grasp domain | Ribosomal L11/L12e N-terminal domain | 1 | 1 |  |
| Carbon-nitrogen hydrolase | NAC domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Nucleic acid-binding proteins | 1 | 1 |  |
| MFS general substrate transporter | L domain-like | 1 | 1 |  |
| SNARE-like | WD40 repeat-like | 1 | 1 |  |
| Glycosyl hydrolase domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Hypothetical protein PA1324 | Carboxypeptidase regulatory domain-like | 1 | 1 |  |
| Taf5 N-terminal domain-like | WD40 repeat-like | 1 | 1 |  |
| TPR-like | Metallo-dependent phosphatases | 1 | 1 |  |
| GST C-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| CI-2 family of serine protease inhibitors | CI-2 family of serine protease inhibitors | 1 | 1 |  |
| post-AAA+ oligomerization domain-like | PLP-dependent transferases | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Methylglyoxal synthase-like | 1 | 1 |  |
| Flavoproteins | Flavoproteins | 1 | 1 |  |
| Stabilizer of iron transporter SufD | Stabilizer of iron transporter SufD | 1 | 1 |  |
| LeuD/IlvD-like | EF-hand | 1 | 1 |  |
| DNA/RNA polymerases | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| PAP/OAS1 substrate-binding domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| Trypsin-like serine proteases | TPR-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Acid proteases | 1 | 1 |  |
| vWA-like | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| GroEL-intermediate domain like | Galactose mutarotase-like | 1 | 1 |  |
| Dom34/Pelota N-terminal domain-like | Dom34/Pelota N-terminal domain-like | 1 | 1 |  |
| Hypothetical protein c14orf129, hspc210 | TPR-like | 1 | 1 |  |
| E set domains | FAD-linked reductases, C-terminal domain | 1 | 1 |  |
| Rhomboid-like | UBA-like | 1 | 1 |  |
| CRAL/TRIO N-terminal domain | SNARE-like | 1 | 1 |  |
| Subtilisin-like | SpoIIaa-like | 1 | 1 |  |
| BRCT domain | post-AAA+ oligomerization domain-like | 1 | 1 |  |
| GroEL equatorial domain-like | Cysteine proteinases | 1 | 1 |  |
| TRAF domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| CAD & PB1 domains | ssDNA-binding transcriptional regulator domain | 1 | 1 |  |
| Histone-fold | Homeodomain-like | 1 | 1 |  |
| Aquaporin-like | Aquaporin-like | 1 | 1 |  |
| Terpenoid synthases | Cytochrome P450 | 1 | 1 |  |
| Trypsin-like serine proteases | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| RNA-binding domain, RBD | PWI domain | 1 | 1 |  |
| Cyclophilin-like | Ribonuclease PH domain 2-like | 1 | 1 |  |
| SAM/Pointed domain | RING/U-box | 1 | 1 |  |
| WD40 repeat-like | Isocitrate/Isopropylmalate dehydrogenase-like | 1 | 1 |  |
| beta-Galactosidase/glucuronidase domain | Galactose mutarotase-like | 1 | 1 |  |
| Calcium ATPase, transduction domain A | Histone-fold | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | PK C-terminal domain-like | 1 | 1 |  |
| Urease, beta-subunit | Metallo-dependent hydrolases | 1 | 1 |  |
| TGS-like | Class II aaRS ABD-related | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | Homeodomain-like | 1 | 1 |  |
| Voltage-gated potassium channels | Ubiquitin-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | beta-beta-alpha zinc fingers | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | NAC domain | 1 | 1 |  |
| Hypothetical protein PA1324 | Cna protein B-type domain | 1 | 1 |  |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Nucleotidylyl transferase | 1 | 1 |  |
| Leucine zipper domain | "Winged helix" DNA-binding domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | ARID-like | 1 | 1 |  |
| Sm-like ribonucleoproteins | Ribosomal protein S3 C-terminal domain | 1 | 1 |  |
| ClpS-like | Leucine zipper domain | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | CO dehydrogenase flavoprotein C-terminal domain-like | 1 | 1 |  |
| alpha/beta-Hydrolases | Ribonuclease H-like | 1 | 1 |  |
| PP2C-like | cAMP-binding domain-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | PAP/OAS1 substrate-binding domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | UBC-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Nop domain | 1 | 1 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | 1 |  |
| DNA-binding domain | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| (Trans)glycosidases | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Heat shock protein 70kD (HSP70), peptide-binding domain | AF0104/ALDC/Ptd012-like | 1 | 1 |  |
| PLP-dependent transferases | beta-beta-alpha zinc fingers | 1 | 1 |  |
| WD40 repeat-like | SNARE fusion complex | 1 | 1 |  |
| Myosin rod fragments | Myosin rod fragments | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | RplX-like | 1 | 1 |  |
| DNA ligase/mRNA capping enzyme, catalytic domain | BRCT domain | 1 | 1 |  |
| Actin-like ATPase domain | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| DPP6 N-terminal domain-like | Ubiquitin-like | 1 | 1 |  |
| Eukaryotic type KH-domain (KH-domain type I) | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Ribokinase-like | Thiamin phosphate synthase | 1 | 1 |  |
| Ribonuclease PH domain 2-like | DNA/RNA polymerases | 1 | 1 |  |
| HMA, heavy metal-associated domain | Histone-fold | 1 | 1 |  |
| Galactose mutarotase-like | SGNH hydrolase | 1 | 1 |  |
| Metallo-dependent phosphatases | DNase I-like | 1 | 1 |  |
| HMA, heavy metal-associated domain | Glycerol-3-phosphate (1)-acyltransferase | 1 | 1 |  |
| GAD domain-like | Mog1p/PsbP-like | 1 | 1 |  |
| Homeodomain-like | Acid proteases | 1 | 1 |  |
| Protein kinase-like (PK-like) | GroEL-intermediate domain like | 1 | 1 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | CRAL/TRIO domain | 1 | 1 |  |
| Acetyl-CoA synthetase-like | ACP-like | 1 | 1 |  |
| Metal cation-transporting ATPase, ATP-binding domain N | (Trans)glycosidases | 1 | 1 |  |
| Fumarylacetoacetate hydrolase, FAH, N-terminal domain | FAH | 1 | 1 |  |
| Plant invertase/pectin methylesterase inhibitor | Plant invertase/pectin methylesterase inhibitor | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | Cytochrome P450 | 1 | 1 |  |
| HMA, heavy metal-associated domain | Six-hairpin glycosidases | 1 | 1 |  |
| Tricorn protease domain 2 | Zn-binding ribosomal proteins | 1 | 1 |  |
| Clavaminate synthase-like | Chaperone J-domain | 1 | 1 |  |
| Cytochrome P450 | Thiamin diphosphate-binding fold (THDP-binding) | 1 | 1 |  |
| Leucine zipper domain | Thioredoxin-like | 1 | 1 |  |
| Ribosome recycling factor, RRF | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| RNA-binding domain, RBD | Mss4-like | 1 | 1 |  |
| ARM repeat | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| Ammonium transporter | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Tetrahydrobiopterin biosynthesis enzymes-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| MoeA N-terminal region -like | Molybdenum cofactor biosynthesis proteins | 1 | 1 |  |
| FAD/NAD(P)-binding domain | SMAD/FHA domain | 1 | 1 |  |
| Bromodomain | Bromodomain | 1 | 1 |  |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | Aldolase | 1 | 1 |  |
| Terpenoid synthases | DNA/RNA polymerases | 1 | 1 |  |
| Clavaminate synthase-like | Acid proteases | 1 | 1 |  |
| PurS-like | FGAM synthase PurL, linker domain | 1 | 1 |  |
| Translation proteins SH3-like domain | Ribosomal protein L16p/L10e | 1 | 1 |  |
| Tricorn protease N-terminal domain | alpha/beta-Hydrolases | 1 | 1 |  |
| DNA-binding domain | Ran binding protein zinc finger-like | 1 | 1 |  |
| Rudiment single hybrid motif | ClpP/crotonase | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | DNA clamp | 1 | 1 |  |
| Ran binding protein zinc finger-like | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| (Trans)glycosidases | CRAL/TRIO N-terminal domain | 1 | 1 |  |
| DTD-like | DTD-like | 1 | 1 |  |
| FAD-linked oxidoreductase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| PYP-like sensor domain (PAS domain) | Galactose oxidase, central domain | 1 | 1 |  |
| Activator of Hsp90 ATPase, Aha1 | Bet v1-like | 1 | 1 |  |
| LDL receptor-like module | PK C-terminal domain-like | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | vWA-like | 1 | 1 |  |
| ARID-like | Clavaminate synthase-like | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| FYVE/PHD zinc finger | ENTH/VHS domain | 1 | 1 |  |
| Homeodomain-like | Clathrin adaptor appendage domain | 1 | 1 |  |
| all-alpha NTP pyrophosphatases | all-alpha NTP pyrophosphatases | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | ADP-ribosylation | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Tudor/PWWP/MBT | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | NagB/RpiA/CoA transferase-like | 1 | 1 |  |
| Amine oxidase catalytic domain | TK C-terminal domain-like | 1 | 1 |  |
| Cysteine proteinases | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| ARM repeat | Zn-binding ribosomal proteins | 1 | 1 |  |
| Fe-S cluster assembly (FSCA) domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| F-box domain | NHL repeat | 1 | 1 |  |
| Trimeric LpxA-like enzymes | Heme-dependent catalase-like | 1 | 1 |  |
| tRNA-guanine transglycosylase | tRNA-guanine transglycosylase | 1 | 1 |  |
| CRAL/TRIO N-terminal domain | UBC-like | 1 | 1 |  |
| Kelch motif | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | 1 |  |
| Enolase C-terminal domain-like | Enolase C-terminal domain-like | 1 | 1 |  |
| Calponin-homology domain, CH-domain | DNase I-like | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | SH2 domain | 1 | 1 |  |
| RNA-binding domain, RBD | Calcium ATPase, transmembrane domain M | 1 | 1 |  |
| TPR-like | (Trans)glycosidases | 1 | 1 |  |
| Protein prenylyltransferase | L domain-like | 1 | 1 |  |
| cAMP-binding domain-like | ADP-ribosylation | 1 | 1 |  |
| Composite domain of metallo-dependent hydrolases | Protein kinase-like (PK-like) | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Phosphoglycerate mutase-like | 1 | 1 |  |
| Calpain large subunit, middle domain (domain III) | FYVE/PHD zinc finger | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | ARM repeat | 1 | 1 |  |
| Protein kinase-like (PK-like) | DNase I-like | 1 | 1 |  |
| HIT/MYND zinc finger-like | SET domain | 1 | 1 |  |
| Aquaporin-like | Nucleotidyltransferase | 1 | 1 |  |
| Nucleic acid-binding proteins | Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | 1 |  |
| Ran binding protein zinc finger-like | Translation proteins | 1 | 1 |  |
| PP2C-like | MFS general substrate transporter | 1 | 1 |  |
| Homeodomain-like | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| HMA, heavy metal-associated domain | Chlorophyll a-b binding protein | 1 | 1 |  |
| Thioredoxin-like | NHL repeat | 1 | 1 |  |
| Molybdenum cofactor biosynthesis protein C, MoaC | EF-hand | 1 | 1 |  |
| MFS general substrate transporter | FAD-dependent thiol oxidase | 1 | 1 |  |
| S13-like H2TH domain | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Tropomyosin | PLC-like phosphodiesterases | 1 | 1 |  |
| Mss4-like | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| PRP4-like | Cupredoxins | 1 | 1 |  |
| Metal cation-transporting ATPase, ATP-binding domain N | Six-hairpin glycosidases | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 1 | 1 |  |
| PP2C-like | ClpP/crotonase | 1 | 1 |  |
| eIF1-like | RING/U-box | 1 | 1 |  |
| Nucleic acid-binding proteins | Phosphoglycerate mutase-like | 1 | 1 |  |
| Actin-like ATPase domain | post-AAA+ oligomerization domain-like | 1 | 1 |  |
| PIN domain-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | eIF1-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | FAD/NAD(P)-binding domain | 1 | 1 |  |
| YbaK/ProRS associated domain | YbaK/ProRS associated domain | 1 | 1 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | beta-beta-alpha zinc fingers | 1 | 1 |  |
| vWA-like | SPOC domain-like | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 |  |
| EF-hand | Ankyrin repeat | 1 | 1 |  |
| Protein kinase-like (PK-like) | Ran binding protein zinc finger-like | 1 | 1 |  |
| Chaperone J-domain | Ribonuclease H-like | 1 | 1 |  |
| Chaperone J-domain | HSC20 (HSCB), C-terminal oligomerisation domain | 1 | 1 |  |
| EF-hand | Trimeric LpxA-like enzymes | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Histone-fold | 1 | 1 |  |
| Tudor/PWWP/MBT | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| HSP20-like chaperones | Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | 1 |  |
| Formin homology 2 domain (FH2 domain) | Tudor/PWWP/MBT | 1 | 1 |  |
| Riboflavin synthase domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| SRF-like | Clavaminate synthase-like | 1 | 1 |  |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | HD-domain/PDEase-like | 1 | 1 |  |
| Nucleic acid-binding proteins | WRKY DNA-binding domain | 1 | 1 |  |
| SIS domain | SIS domain | 1 | 1 |  |
| Clavaminate synthase-like | RING/U-box | 1 | 1 |  |
| ArfGap/RecO-like zinc finger | ArfGap/RecO-like zinc finger | 1 | 1 |  |
| MFS general substrate transporter | RNA-binding domain, RBD | 1 | 1 |  |
| DNA-binding pseudobarrel domain | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| EF-hand | DNA/RNA polymerases | 1 | 1 |  |
| ATP12-like | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| Actin depolymerizing proteins | TAZ domain | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | POZ domain | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | BRCT domain | 1 | 1 |  |
| CRAL/TRIO domain | UBC-like | 1 | 1 |  |
| Aldolase | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 1 | 1 |  |
| Thioesterase/thiol ester dehydrase-isomerase | Actin-crosslinking proteins | 1 | 1 |  |
| UBC-like | AF0104/ALDC/Ptd012-like | 1 | 1 |  |
| NAC domain | Pseudouridine synthase | 1 | 1 |  |
| Creatinase/aminopeptidase | GroES-like | 1 | 1 |  |
| FYVE/PHD zinc finger | GYF domain | 1 | 1 |  |
| Acyl-CoA binding protein | Translation proteins | 1 | 1 |  |
| UBA-like | Glycosyl hydrolase domain | 1 | 1 |  |
| Ribosomal protein L29 (L29p) | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Cytochrome P450 | Phosphoglycerate mutase-like | 1 | 1 |  |
| RING/U-box | HAD-like | 1 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | F-box domain | 1 | 1 |  |
| Cystatin/monellin | Tubulin C-terminal domain-like | 1 | 1 |  |
| Arginase/deacetylase | RING/U-box | 1 | 1 |  |
| WD40 repeat-like | RL5-like | 1 | 1 |  |
| Ankyrin repeat | GST C-terminal domain-like | 1 | 1 |  |
| Creatinase/aminopeptidase | ACT-like | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | (Trans)glycosidases | 1 | 1 |  |
| FAD/NAD(P)-binding domain | HI0933 insert domain-like | 1 | 1 |  |
| HAD-like | Ribosomal protein S6 | 1 | 1 |  |
| Urease, beta-subunit | Composite domain of metallo-dependent hydrolases | 1 | 1 |  |
| Glycosyl hydrolase domain | L domain-like | 1 | 1 |  |
| Osmotin, thaumatin-like protein | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | CO dehydrogenase ISP C-domain like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Thioredoxin-like | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| Ribosomal protein S8 | Sm-like ribonucleoproteins | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Pectin lyase-like | 1 | 1 |  |
| RING/U-box | ALDH-like | 1 | 1 |  |
| Cupredoxins | TRAF domain-like | 1 | 1 |  |
| Hairpin loop containing domain-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | RING/U-box | 1 | 1 |  |
| N-utilization substance G protein NusG, N-terminal domain | Translation proteins SH3-like domain | 1 | 1 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | Beta-D-glucan exohydrolase, C-terminal domain | 1 | 1 |  |
| TRAF domain-like | ARM repeat | 1 | 1 |  |
| Cyclophilin-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
| Acid proteases | AlbA-like | 1 | 1 |  |
| HCP-like | Cupredoxins | 1 | 1 |  |
| F-box domain | Pectin lyase-like | 1 | 1 |  |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | Heme-dependent peroxidases | 1 | 1 |  |
| Oxysterol-binding protein-like | Homeodomain-like | 1 | 1 |  |
| NAD kinase/diacylglycerol kinase-like | alpha/beta-Hydrolases | 1 | 1 |  |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | Dihydropteroate synthetase-like | 1 | 1 |  |
| CHY zinc finger-like | Zinc hairpin stack | 1 | 1 |  |
| Protein kinase-like (PK-like) | SNARE fusion complex | 1 | 1 |  |
| Terpenoid cyclases/Protein prenyltransferases | Retrovirus zinc finger-like domains | 1 | 1 |  |
| POZ domain | DNase I-like | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Fe-S cluster assembly (FSCA) domain-like | 1 | 1 |  |
| alpha/beta-Hydrolases | Ubiquitin-like | 1 | 1 |  |
| CYTH-like phosphatases | Ribonuclease H-like | 1 | 1 |  |
| L domain-like | GST C-terminal domain-like | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | CRAL/TRIO N-terminal domain | 1 | 1 |  |
| DNA/RNA polymerases | ENTH/VHS domain | 1 | 1 |  |
| beta-beta-alpha zinc fingers | Homeodomain-like | 1 | 1 |  |
| TPR-like | UBC-like | 1 | 1 |  |
| UBC-like | UBA-like | 1 | 1 |  |
| Myosin rod fragments | RNA-binding domain, RBD | 1 | 1 |  |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Aquaporin-like | 1 | 1 |  |
| Acid phosphatase/Vanadium-dependent haloperoxidase | beta-beta-alpha zinc fingers | 1 | 1 |  |
| POZ domain | SRF-like | 1 | 1 |  |
| RmlC-like cupins | Mob1/phocein | 1 | 1 |  |
| Ran binding protein zinc finger-like | ENT-like | 1 | 1 |  |
| Ligand-binding domain in the NO signalling and Golgi transport | FabD/lysophospholipase-like | 1 | 1 |  |
| SpoIIaa-like | HAD-like | 1 | 1 |  |
| Lipoxigenase | Lipoxigenase | 1 | 1 |  |
| Protein kinase-like (PK-like) | Tautomerase/MIF | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | SGNH hydrolase | 1 | 1 |  |
| Pentapeptide repeat-like | Pentapeptide repeat-like | 1 | 1 |  |
| Ribonuclease H-like | Cyclophilin-like | 1 | 1 |  |
| Cullin repeat-like | Cullin repeat-like | 1 | 1 |  |
| MFS general substrate transporter | GroEL apical domain-like | 1 | 1 |  |
| DNA/RNA polymerases | Subdomain of clathrin and coatomer appendage domain | 1 | 1 |  |
| Voltage-gated potassium channels | SpoIIaa-like | 1 | 1 |  |
| ARM repeat | FAD/NAD(P)-binding domain | 1 | 1 |  |
| MAL13P1.257-like | MAL13P1.257-like | 1 | 1 |  |
| Aspartate/glutamate racemase | Aspartate/glutamate racemase | 1 | 1 |  |
| Class II aaRS ABD-related | Homeodomain-like | 1 | 1 |  |
| Thiolase-like | Ypt/Rab-GAP domain of gyp1p | 1 | 1 |  |
| AraD/HMP-PK domain-like | AraD/HMP-PK domain-like | 1 | 1 |  |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | PP2C-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | (Trans)glycosidases | 1 | 1 |  |
| Dihydrofolate reductase-like | Thymidylate synthase/dCMP hydroxymethylase | 1 | 1 |  |
| Protein kinase-like (PK-like) | HD-domain/PDEase-like | 1 | 1 |  |
| E set domains | HCP-like | 1 | 1 |  |
| L domain-like | Ankyrin repeat | 1 | 1 |  |
| Acetyl-CoA synthetase-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| alpha/beta-Hydrolases | Zinc beta-ribbon | 1 | 1 |  |
| SRF-like | RING/U-box | 1 | 1 |  |
| beta-carbonic anhydrase, cab | Endosomal sorting complex assembly domain | 1 | 1 |  |
| Carbamoyl phosphate synthetase, large subunit connection domain | Methylglyoxal synthase-like | 1 | 1 |  |
| ATP-dependent DNA ligase DNA-binding domain | Nucleic acid-binding proteins | 1 | 1 |  |
| Plant invertase/pectin methylesterase inhibitor | Retrovirus zinc finger-like domains | 1 | 1 |  |
| eIF1-like | Multidrug resistance efflux transporter EmrE | 1 | 1 |  |
| TPR-like | HIT/MYND zinc finger-like | 1 | 1 |  |
| Tubulin nucleotide-binding domain-like | Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) | 1 | 1 |  |
| PUA domain-like | Ribosomal proteins L15p and L18e | 1 | 1 |  |
| ARM repeat | Carbonic anhydrase | 1 | 1 |  |
| RNA-binding domain, RBD | Purple acid phosphatase, N-terminal domain | 1 | 1 |  |
| HAD-like | Calcium-dependent phosphotriesterase | 1 | 1 |  |
| Lysozyme-like | Lysozyme-like | 1 | 1 |  |
| Homeodomain-like | L domain-like | 1 | 1 |  |
| MFS general substrate transporter | HSP20-like chaperones | 1 | 1 |  |
| L domain-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| Cysteine proteinases | Periplasmic binding protein-like I | 1 | 1 |  |
| Saposin | WRKY DNA-binding domain | 1 | 1 |  |
| alpha/beta-Hydrolases | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Acid proteases | Clathrin heavy-chain terminal domain | 1 | 1 |  |
| Acetyl-CoA synthetase-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| FYVE/PHD zinc finger | GAT-like domain | 1 | 1 |  |
| TPR-like | NAD kinase/diacylglycerol kinase-like | 1 | 1 |  |
| NAD(P)-linked oxidoreductase | ARM repeat | 1 | 1 |  |
| Formyltransferase | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | 1 |  |
| F-box domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| N-terminal domain of adenylylcyclase associated protein, CAP | (Trans)glycosidases | 1 | 1 |  |
| WD40 repeat-like | Cyclophilin-like | 1 | 1 |  |
| NAC domain | DNA/RNA polymerases | 1 | 1 |  |
| Oxygen-evolving enhancer protein 3, | Cyclophilin-like | 1 | 1 |  |
| Ankyrin repeat | HCP-like | 1 | 1 |  |
| AF0104/ALDC/Ptd012-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Acid proteases | Sm-like ribonucleoproteins | 1 | 1 |  |
| Aquaporin-like | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | FabD/lysophospholipase-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Homing endonucleases | 1 | 1 |  |
| Activating enzymes of the ubiquitin-like proteins | PEBP-like | 1 | 1 |  |
| GroEL-intermediate domain like | SAICAR synthase-like | 1 | 1 |  |
| PheT/TilS domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
| DNA/RNA polymerases | Thioredoxin-like | 1 | 1 |  |
| Phosphoglycerate kinase | Clavaminate synthase-like | 1 | 1 |  |
| CAD & PB1 domains | F-box domain | 1 | 1 |  |
| Ubiquitin-like | Glycosyl hydrolase domain | 1 | 1 |  |
| YgbK-like | Aldolase | 1 | 1 |  |
| alpha-D-mannose-specific plant lectins | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| RING/U-box | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| WD40 repeat-like | GroEL apical domain-like | 1 | 1 |  |
| RmlC-like cupins | EF-hand | 1 | 1 |  |
| BRCT domain | Homeodomain-like | 1 | 1 |  |
| L-aspartase-like | Bet v1-like | 1 | 1 |  |
| Calcium ATPase, transduction domain A | Six-hairpin glycosidases | 1 | 1 |  |
| SRF-like | Cupredoxins | 1 | 1 |  |
| HSP20-like chaperones | RmlC-like cupins | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | Fucose-specific lectin | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | DNA-glycosylase | 1 | 1 |  |
| Thioesterase/thiol ester dehydrase-isomerase | PLC-like phosphodiesterases | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| Subtilisin-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| SPOC domain-like | SAP domain | 1 | 1 |  |
| Nucleic acid-binding proteins | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| PP2C-like | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| Alanine racemase C-terminal domain-like | Thymidylate synthase/dCMP hydroxymethylase | 1 | 1 |  |
| Aldolase | Protein kinase-like (PK-like) | 1 | 1 |  |
| PDZ domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Ubiquitin-like | Acid proteases | 1 | 1 |  |
| alpha/beta knot | alpha/beta knot | 1 | 1 |  |
| RNI-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| DnaJ/Hsp40 cysteine-rich domain | HSC20 (HSCB), C-terminal oligomerisation domain | 1 | 1 |  |
| RNA-binding domain, RBD | Calcium ATPase, transduction domain A | 1 | 1 |  |
| alpha/beta-Hydrolases | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| BRCA2 helical domain | Nucleic acid-binding proteins | 1 | 1 |  |
| RNA-binding domain, RBD | HCP-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Histone-fold | 1 | 1 |  |
| Leucine zipper domain | GST C-terminal domain-like | 1 | 1 |  |
| Acetyl-CoA synthetase-like | The spindle assembly checkpoint protein mad2 | 1 | 1 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | Enolase C-terminal domain-like | 1 | 1 |  |
| Six-hairpin glycosidases | At5g01610-like | 1 | 1 |  |
| GroEL-intermediate domain like | Mitochondrial carrier | 1 | 1 |  |
| E set domains | FAD/NAD(P)-binding domain | 1 | 1 |  |
| Cytochrome P450 | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | DNA mismatch repair protein MutL | 1 | 1 |  |
| DNA/RNA polymerases | Clathrin adaptor appendage domain | 1 | 1 |  |
| Homeodomain-like | ARM repeat | 1 | 1 |  |
| XPC-binding domain | Preprotein translocase SecY subunit | 1 | 1 |  |
| Zn-dependent exopeptidases | PH domain-like | 1 | 1 |  |
| Leucine zipper domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| ISP domain | Chlorophyll a-b binding protein | 1 | 1 |  |
| Tudor/PWWP/MBT | DNA repair protein MutS, domain II | 1 | 1 |  |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| alpha/beta-Hydrolases | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| Calcium ATPase, transduction domain A | L domain-like | 1 | 1 |  |
| MoeA N-terminal region -like | MoeA C-terminal domain-like | 1 | 1 |  |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | Ypt/Rab-GAP domain of gyp1p | 1 | 1 |  |
| Pectin lyase-like | Barwin-like endoglucanases | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | t-snare proteins | 1 | 1 |  |
| Ypt/Rab-GAP domain of gyp1p | S-adenosylmethionine decarboxylase | 1 | 1 |  |
| WWE domain | ADP-ribosylation | 1 | 1 |  |
| Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) | ACP-like | 1 | 1 |  |
| Dihydrofolate reductase-like | YbiA-like | 1 | 1 |  |
| L30e-like | alpha/beta knot | 1 | 1 |  |
| Trigger factor ribosome-binding domain | FKBP-like | 1 | 1 |  |
| PDZ domain-like | Rubredoxin-like | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| SRF-like | RCC1/BLIP-II | 1 | 1 |  |
| Riboflavin synthase domain-like | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| PLP-dependent transferases | eEF1-gamma domain | 1 | 1 |  |
| CAD & PB1 domains | Clavaminate synthase-like | 1 | 1 |  |
| Ribosomal protein L22 | DNA/RNA polymerases | 1 | 1 |  |
| IlvD/EDD N-terminal domain-like | EF-hand | 1 | 1 |  |
| Ribonuclease H-like | Preprotein translocase SecY subunit | 1 | 1 |  |
| Aquaporin-like | RING/U-box | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | Molybdenum cofactor-binding domain | 1 | 1 |  |
| SAICAR synthase-like | ARID-like | 1 | 1 |  |
| Putative DNA-binding domain | PheT/TilS domain | 1 | 1 |  |
| Creatinase/aminopeptidase | RplX-like | 1 | 1 |  |
| (Trans)glycosidases | Metallo-dependent phosphatases | 1 | 1 |  |
| Cytochrome P450 | WW domain | 1 | 1 |  |
| Translation initiation factor IF3, N-terminal domain | Translation initiation factor IF3, N-terminal domain | 1 | 1 |  |
| Ribonuclease PH domain 2-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
| L domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Chaperone J-domain | ARM repeat | 1 | 1 |  |
| ABC transporter transmembrane region | Inorganic pyrophosphatase | 1 | 1 |  |
| Indigoidine synthase A-like | Indigoidine synthase A-like | 1 | 1 |  |
| Magnesium transport protein CorA, transmembrane region | DNA/RNA polymerases | 1 | 1 |  |
| PurM C-terminal domain-like | PurM C-terminal domain-like | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | E set domains | 1 | 1 |  |
| FAD-linked oxidoreductase | Domain of the SRP/SRP receptor G-proteins | 1 | 1 |  |
| Cyclophilin-like | Cyclophilin-like | 1 | 1 |  |
| PurS-like | PurM N-terminal domain-like | 1 | 1 |  |
| (Trans)glycosidases | HCP-like | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 |  |
| HAND domain of the nucleosome remodeling ATPase ISWI | Nop domain | 1 | 1 |  |
| HAD-like | Homeodomain-like | 1 | 1 |  |
| "Winged helix" DNA-binding domain | Zinc beta-ribbon | 1 | 1 |  |
| RuvA domain 2-like | RuvA domain 2-like | 1 | 1 |  |
| MFS general substrate transporter | Mitochondrial carrier | 1 | 1 |  |
| TRAF domain-like | CAD & PB1 domains | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| ClpP/crotonase | Clavaminate synthase-like | 1 | 1 |  |
| Helical domain of Sec23/24 | ARM repeat | 1 | 1 |  |
| Retrovirus zinc finger-like domains | CoA-dependent acyltransferases | 1 | 1 |  |
| (Trans)glycosidases | Galactose oxidase, central domain | 1 | 1 |  |
| Carbon-nitrogen hydrolase | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| PH domain-like | HMG-box | 1 | 1 |  |
| GYF domain | F-box domain | 1 | 1 |  |
| Acyl-CoA binding protein | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | alpha-D-mannose-specific plant lectins | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | PP2C-like | 1 | 1 |  |
| CAD & PB1 domains | Mannose-binding lectins | 1 | 1 |  |
| PP2C-like | RNA-binding domain, RBD | 1 | 1 |  |
| EF-hand | F-box domain | 1 | 1 |  |
| Aconitase iron-sulfur domain | ARM repeat | 1 | 1 |  |
| ArfGap/RecO-like zinc finger | Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 1 | 1 |  |
| Rudiment single hybrid motif | Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | CCCH zinc finger | 1 | 1 |  |
| Obg GTP-binding protein N-terminal domain | Obg GTP-binding protein N-terminal domain | 1 | 1 |  |
| Double-stranded DNA-binding domain | Ribonuclease H-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | PK beta-barrel domain-like | 1 | 1 |  |
| Bromodomain | Cyclin-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | PP2C-like | 1 | 1 |  |
| TPR-like | PP2C-like | 1 | 1 |  |
| Periplasmic binding protein-like I | Ubiquitin-like | 1 | 1 |  |
| DNA primase core | CRAL/TRIO domain | 1 | 1 |  |
| DNA/RNA polymerases | Bet v1-like | 1 | 1 |  |
| F-box domain | AlbA-like | 1 | 1 |  |
| CYTH-like phosphatases | DNA/RNA polymerases | 1 | 1 |  |
| L domain-like | SBT domain | 1 | 1 |  |
| Homeodomain-like | Periplasmic binding protein-like II | 1 | 1 |  |
| SNARE-like | PRP4-like | 1 | 1 |  |
| alpha-helical ferredoxin | Nucleotide-binding domain | 1 | 1 |  |
| Amidase signature (AS) enzymes | Protein kinase-like (PK-like) | 1 | 1 |  |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
| Cytochrome f, large domain | Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor | 1 | 1 |  |
| Macro domain-like | CRAL/TRIO domain | 1 | 1 |  |
| PGBD-like | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
| HAD-like | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | Calcium-dependent phosphotriesterase | 1 | 1 |  |
| TPR-like | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| At5g01610-like | cAMP-binding domain-like | 1 | 1 |  |
| Actin-like ATPase domain | AF0104/ALDC/Ptd012-like | 1 | 1 |  |
| YjgF-like | YjgF-like | 1 | 1 |  |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | Ypt/Rab-GAP domain of gyp1p | 1 | 1 |  |
| PYP-like sensor domain (PAS domain) | TPR-like | 1 | 1 |  |
| AF0104/ALDC/Ptd012-like | Concanavalin A-like lectins/glucanases | 1 | 1 |  |
| TPR-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Cupredoxins | beta and beta-prime subunits of DNA dependent RNA-polymerase | 1 | 1 |  |
| HAD-like | L domain-like | 1 | 1 |  |
| Ribonuclease H-like | F1F0 ATP synthase subunit C | 1 | 1 |  |
| Acetyl-CoA synthetase-like | Chaperone J-domain | 1 | 1 |  |
| Urease, gamma-subunit | Composite domain of metallo-dependent hydrolases | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Homeodomain-like | 1 | 1 |  |
| alpha/beta-Hydrolases | Acid proteases | 1 | 1 |  |
| HMA, heavy metal-associated domain | Phosphoglycerate mutase-like | 1 | 1 |  |
| CBS-domain pair | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| ARM repeat | E2F-DP heterodimerization region | 1 | 1 |  |
| DNA/RNA polymerases | Clathrin heavy-chain terminal domain | 1 | 1 |  |
| ThrRS/AlaRS common domain | PP2C-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | vWA-like | 1 | 1 |  |
| FAD/NAD(P)-binding domain | ACP-like | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | YjgF-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Chromo domain-like | 1 | 1 |  |
| Translation initiation factor 2 beta, aIF2beta, N-terminal domain | ClpP/crotonase | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | alpha-D-mannose-specific plant lectins | 1 | 1 |  |
| PLP-dependent transferases | GST C-terminal domain-like | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | Class I glutamine amidotransferase-like | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | Thioredoxin-like | 1 | 1 |  |
| 4'-phosphopantetheinyl transferase | 4'-phosphopantetheinyl transferase | 1 | 1 |  |
| NTF2-like | 6-phosphogluconate dehydrogenase C-terminal domain-like | 1 | 1 |  |
| CRAL/TRIO domain | SNARE-like | 1 | 1 |  |
| Homeodomain-like | Periplasmic binding protein-like I | 1 | 1 |  |
| Carbamate kinase-like | RING/U-box | 1 | 1 |  |
| FAD-linked reductases, C-terminal domain | 4Fe-4S ferredoxins | 1 | 1 |  |
| HAD-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| ClpS-like | SRF-like | 1 | 1 |  |
| Subtilisin-like | Tubby C-terminal domain-like | 1 | 1 |  |
| vWA-like | Cysteine-rich domain | 1 | 1 |  |
| NAD(P)-linked oxidoreductase | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Cyclophilin-like | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | L domain-like | 1 | 1 |  |
| Ankyrin repeat | WD40 repeat-like | 1 | 1 |  |
| HMA, heavy metal-associated domain | TrmE connector domain | 1 | 1 |  |
| GroES-like | RplX-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | Clathrin adaptor appendage domain | 1 | 1 |  |
| WD40 repeat-like | GroEL-intermediate domain like | 1 | 1 |  |
| HMA, heavy metal-associated domain | RCC1/BLIP-II | 1 | 1 |  |
| Actin-like ATPase domain | (Trans)glycosidases | 1 | 1 |  |
| RNA-binding domain, RBD | F-box domain | 1 | 1 |  |
| Multidrug resistance efflux transporter EmrE | Acid proteases | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
| L9 N-domain-like | Ribonuclease H-like | 1 | 1 |  |
| Rhodanese/Cell cycle control phosphatase | Ricin B-like lectins | 1 | 1 |  |
| RNI-like | Thioredoxin-like | 1 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | ArfGap/RecO-like zinc finger | 1 | 1 |  |
| Pectin lyase-like | ssDNA-binding transcriptional regulator domain | 1 | 1 |  |
| RING/U-box | Prefoldin | 1 | 1 |  |
| Mitochondrial glycoprotein MAM33-like | Glycerol-3-phosphate (1)-acyltransferase | 1 | 1 |  |
| Rhomboid-like | Ran binding protein zinc finger-like | 1 | 1 |  |
| DNA repair protein MutS, domain III | SMR domain-like | 1 | 1 |  |
| GAF domain-like | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| Barwin-like endoglucanases | Cdc48 domain 2-like | 1 | 1 |  |
| Nucleic acid-binding proteins | BRCA2 tower domain | 1 | 1 |  |
| SRF-like | Leucine zipper domain | 1 | 1 |  |
| Cyclophilin-like | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Thioredoxin-like | Nqo1C-terminal domain-like | 1 | 1 |  |
| TPR-like | PH domain-like | 1 | 1 |  |
| LysM domain | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| Plant invertase/pectin methylesterase inhibitor | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| MFS general substrate transporter | Cytochrome c oxidase subunit h | 1 | 1 |  |
| Galactose-binding domain-like | Ribonuclease H-like | 1 | 1 |  |
| Pectin lyase-like | Chlorophyll a-b binding protein | 1 | 1 |  |
| Glycoside hydrolase/deacetylase | Glycoside hydrolase/deacetylase | 1 | 1 |  |
| RING/U-box | Ribosomal protein L32e | 1 | 1 |  |
| PLP-binding barrel | Thymidylate synthase/dCMP hydroxymethylase | 1 | 1 |  |
| Cystatin/monellin | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| Calpain large subunit, middle domain (domain III) | RING/U-box | 1 | 1 |  |
| SRF-like | Thioredoxin-like | 1 | 1 |  |
| HAD-like | TPR-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Mitochondrial carrier | 1 | 1 |  |
| Cation efflux protein transmembrane domain-like | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | GroEL apical domain-like | 1 | 1 |  |
| DNA primase core | DNA primase core | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | Seven-hairpin glycosidases | 1 | 1 |  |
| FabD/lysophospholipase-like | TPR-like | 1 | 1 |  |
| Ribonuclease H-like | C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | 1 |  |
| RmlC-like cupins | Histone-fold | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Clavaminate synthase-like | 1 | 1 |  |
| SBT domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| WD40 repeat-like | Tricorn protease domain 2 | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | TAZ domain | 1 | 1 |  |
| CAD & PB1 domains | RING/U-box | 1 | 1 |  |
| Ubiquitin-like | Cyclophilin-like | 1 | 1 |  |
| PDZ domain-like | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| ATP synthase (F1-ATPase), gamma subunit | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 |  |
| Ran binding protein zinc finger-like | Tudor/PWWP/MBT | 1 | 1 |  |
| Heme-dependent peroxidases | RL5-like | 1 | 1 |  |
| Thioredoxin-like | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Protein kinase-like (PK-like) | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| PDZ domain-like | PDZ domain-like | 1 | 1 |  |
| WD40 repeat-like | YhbY-like | 1 | 1 |  |
| Pseudouridine synthase | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| Kelch motif | Protein kinase-like (PK-like) | 1 | 1 |  |
| Pentein | Pentein | 1 | 1 |  |
| Dom34/Pelota N-terminal domain-like | L30e-like | 1 | 1 |  |
| BSD domain-like | BSD domain-like | 1 | 1 |  |
| Ribonuclease H-like | ERO1-like | 1 | 1 |  |
| Ribonuclease H-like | Single hybrid motif | 1 | 1 |  |
| Urease, gamma-subunit | Urease, beta-subunit | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Dimeric alpha+beta barrel | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | CCCH zinc finger | 1 | 1 |  |
| RmlC-like cupins | TPR-like | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | CRAL/TRIO domain | 1 | 1 |  |
| BEACH domain | BEACH domain | 1 | 1 |  |
| GroEL equatorial domain-like | Mitochondrial carrier | 1 | 1 |  |
| Cysteine proteinases | Calpain large subunit, middle domain (domain III) | 1 | 1 |  |
| HCP-like | WD40 repeat-like | 1 | 1 |  |
| PA domain | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| Chaperone J-domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| RNA-binding domain, RBD | Kelch motif | 1 | 1 |  |
| CBS-domain pair | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| ADP-ribosylation | ADP-ribosylation | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | HCP-like | 1 | 1 |  |
| Lysozyme-like | Trypsin-like serine proteases | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Barwin-like endoglucanases | RNA-binding domain, RBD | 1 | 1 |  |
| FtsH protease domain-like | Nucleic acid-binding proteins | 1 | 1 |  |
| Pseudouridine synthase | Pseudouridine synthase | 1 | 1 |  |
| Translation proteins SH3-like domain | Translation proteins SH3-like domain | 1 | 1 |  |
| LysM domain | UBA-like | 1 | 1 |  |
| FYVE/PHD zinc finger | ARM repeat | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | Histone-fold | 1 | 1 |  |
| RNA-binding domain, RBD | Metal cation-transporting ATPase, ATP-binding domain N | 1 | 1 |  |
| GAF domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | PAP/OAS1 substrate-binding domain | 1 | 1 |  |
| Cyclophilin-like | Ran binding protein zinc finger-like | 1 | 1 |  |
| DNA/RNA polymerases | Nucleic acid-binding proteins | 1 | 1 |  |
| TGS-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| GTPase activation domain, GAP | GTPase activation domain, GAP | 1 | 1 |  |
| Metallo-dependent phosphatases | Thioredoxin-like | 1 | 1 |  |
| DNase I-like | Leucine zipper domain | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | ARM repeat | 1 | 1 |  |
| Actin depolymerizing proteins | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| HMA, heavy metal-associated domain | E set domains | 1 | 1 |  |
| Peptidase/esterase 'gauge' domain | Peptidase/esterase 'gauge' domain | 1 | 1 |  |
| Glycoside hydrolase/deacetylase | SGNH hydrolase | 1 | 1 |  |
| Bactericidal permeability-increasing protein, BPI | Bactericidal permeability-increasing protein, BPI | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Ribosomal L11/L12e N-terminal domain | 1 | 1 |  |
| Macro domain-like | HIT-like | 1 | 1 |  |
| PIN domain-like | MFS general substrate transporter | 1 | 1 |  |
| Cysteine-rich domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
| RNA-binding domain, RBD | ENTH/VHS domain | 1 | 1 |  |
| Phosphofructokinase | Phosphofructokinase | 1 | 1 |  |
| Histone-fold | NAD(P)-linked oxidoreductase | 1 | 1 |  |
| DPP6 N-terminal domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Ribonuclease PH domain 2-like | 1 | 1 |  |
| Ribose/Galactose isomerase RpiB/AlsB | RmlC-like cupins | 1 | 1 |  |
| Histone-fold | ARM repeat | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Ribosomal protein S6 | 1 | 1 |  |
| Aconitase iron-sulfur domain | alpha/beta-Hydrolases | 1 | 1 |  |
| RING/U-box | Zn-dependent exopeptidases | 1 | 1 |  |
| Starch-binding domain-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 |  |
| Aquaporin-like | PAP/OAS1 substrate-binding domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | SMR domain-like | 1 | 1 |  |
| Arginase/deacetylase | PLP-dependent transferases | 1 | 1 |  |
| Helical scaffold and wing domains of SecA | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Cyclin-like | Clavaminate synthase-like | 1 | 1 |  |
| ARM repeat | ClpP/crotonase | 1 | 1 |  |
| BRCA2 helical domain | BRCA2 tower domain | 1 | 1 |  |
| PLP-dependent transferases | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Heme-dependent catalase-like | 1 | 1 |  |
| RNA-binding domain, RBD | L domain-like | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Cysteine proteinases | 1 | 1 |  |
| 5' to 3' exonuclease, C-terminal subdomain | Chromo domain-like | 1 | 1 |  |
| Cyclophilin-like | Nucleic acid-binding proteins | 1 | 1 |  |
| Formyltransferase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| SAP domain | WGR domain-like | 1 | 1 |  |
| LDL receptor-like module | PK beta-barrel domain-like | 1 | 1 |  |
| POZ domain | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| PLP-dependent transferases | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| FMN-linked oxidoreductases | Nucleotide-binding domain | 1 | 1 |  |
| HAD-like | Zn-binding ribosomal proteins | 1 | 1 |  |
| GST C-terminal domain-like | Nucleotidylyl transferase | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | 1 |  |
| Zn-binding ribosomal proteins | Zn-binding ribosomal proteins | 1 | 1 |  |
| Cullin repeat-like | Prefoldin | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| F1F0 ATP synthase subunit C | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Subdomain of clathrin and coatomer appendage domain | 1 | 1 |  |
| Histone-fold | Protein kinase-like (PK-like) | 1 | 1 |  |
| Activator of Hsp90 ATPase, Aha1 | Homeodomain-like | 1 | 1 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | MFS general substrate transporter | 1 | 1 |  |
| ARM repeat | Ribosomal protein L19 (L19e) | 1 | 1 |  |
| Subtilisin-like | Phospholipase D/nuclease | 1 | 1 |  |
| Protein kinase-like (PK-like) | Cysteine proteinases | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Leucine zipper domain | 1 | 1 |  |
| "Winged helix" DNA-binding domain | ACT-like | 1 | 1 |  |
| Sm-like ribonucleoproteins | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | Mitochondrial carrier | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Phospholipase D/nuclease | DNA-glycosylase | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | GMP synthetase C-terminal dimerisation domain | 1 | 1 |  |
| Ribosomal protein S10 | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| Phosphoenolpyruvate/pyruvate domain | PP2C-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Citrate synthase | 1 | 1 |  |
| Trigger factor ribosome-binding domain | Triger factor/SurA peptide-binding domain-like | 1 | 1 |  |
| POZ domain | Ribosomal protein S8 | 1 | 1 |  |
| ACT-like | Formyltransferase | 1 | 1 |  |
| SMAD/FHA domain | PP2C-like | 1 | 1 |  |
| RNI-like | Zn-binding ribosomal proteins | 1 | 1 |  |
| Calponin-homology domain, CH-domain | FYVE/PHD zinc finger | 1 | 1 |  |
| ARM repeat | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | Sm-like ribonucleoproteins | 1 | 1 |  |
| 14-3-3 protein | L domain-like | 1 | 1 |  |
| vWA-like | C-terminal domain of Ku80 | 1 | 1 |  |
| Ubiquitin-like | tRNA-intron endonuclease catalytic domain-like | 1 | 1 |  |
| Indolic compounds 2,3-dioxygenase-like | Mitochondrial carrier | 1 | 1 |  |
| Cupredoxins | Actin-like ATPase domain | 1 | 1 |  |
| L-aspartase-like | Class II aaRS ABD-related | 1 | 1 |  |
| Ribonuclease PH domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
| DNA/RNA polymerases | Sm-like ribonucleoproteins | 1 | 1 |  |
| Plant invertase/pectin methylesterase inhibitor | Chlorophyll a-b binding protein | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | TAZ domain | 1 | 1 |  |
| Subtilisin-like | Ubiquitin-like | 1 | 1 |  |
| POZ domain | WD40 repeat-like | 1 | 1 |  |
| Carbon-nitrogen hydrolase | Heme-dependent peroxidases | 1 | 1 |  |
| HAD-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
| Protein kinase-like (PK-like) | FKBP-like | 1 | 1 |  |
| Formin homology 2 domain (FH2 domain) | Acylphosphatase/BLUF domain-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Translin | 1 | 1 |  |
| Lipoxigenase | EF-hand | 1 | 1 |  |
| Bromodomain | DNA/RNA polymerases | 1 | 1 |  |
| Coproporphyrinogen III oxidase | Ubiquitin-like | 1 | 1 |  |
| PYP-like sensor domain (PAS domain) | Glycerol-3-phosphate (1)-acyltransferase | 1 | 1 |  |
| AlbA-like | Osmotin, thaumatin-like protein | 1 | 1 |  |
| Barwin-like endoglucanases | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| UBA-like | (Trans)glycosidases | 1 | 1 |  |
| EPT/RTPC-like | Mog1p/PsbP-like | 1 | 1 |  |
| BRCT domain | DNA/RNA polymerases | 1 | 1 |  |
| Tudor/PWWP/MBT | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Double Clp-N motif | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| DNA/RNA polymerases | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| Creatinase/aminopeptidase | Creatinase/aminopeptidase | 1 | 1 |  |
| L domain-like | FYVE/PHD zinc finger | 1 | 1 |  |
| Aldolase | Clavaminate synthase-like | 1 | 1 |  |
| Ankyrin repeat | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Galactose mutarotase-like | DNA-binding domain | 1 | 1 |  |
| Aquaporin-like | DNA/RNA polymerases | 1 | 1 |  |
| Sm-like ribonucleoproteins | Sm-like ribonucleoproteins | 1 | 1 |  |
| SAP domain | ADP-ribosylation | 1 | 1 |  |
| Formyltransferase | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Surp module (SWAP domain) | eIF1-like | 1 | 1 |  |
| PH domain-like | PH domain-like | 1 | 1 |  |
| Mog1p/PsbP-like | DNA/RNA polymerases | 1 | 1 |  |
| Cupredoxins | LigB-like | 1 | 1 |  |
| Carbonic anhydrase | DNA/RNA polymerases | 1 | 1 |  |
| Succinyl-CoA synthetase domains | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Mog1p/PsbP-like | Mog1p/PsbP-like | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | E set domains | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | Glycosyl hydrolase domain | 1 | 1 |  |
| Homeodomain-like | Subdomain of clathrin and coatomer appendage domain | 1 | 1 |  |
| PP2C-like | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Protein kinase-like (PK-like) | Chromo domain-like | 1 | 1 |  |
| Thioredoxin-like | Nqo1 middle domain-like | 1 | 1 |  |
| Flavoproteins | Radical SAM enzymes | 1 | 1 |  |
| NTF2-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| PIN domain-like | ARM repeat | 1 | 1 |  |
| PP2C-like | Phosphohistidine domain | 1 | 1 |  |
| TAZ domain | (Trans)glycosidases | 1 | 1 |  |
| FAD-linked oxidases, C-terminal domain | RNA-binding domain, RBD | 1 | 1 |  |
| Translation proteins SH3-like domain | Ribosomal protein S3 C-terminal domain | 1 | 1 |  |
| TPR-like | GST C-terminal domain-like | 1 | 1 |  |
| Rhodanese/Cell cycle control phosphatase | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| Aminoacid dehydrogenase-like, N-terminal domain | DNA/RNA polymerases | 1 | 1 |  |
| SNARE fusion complex | DNase I-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | ClpP/crotonase | 1 | 1 |  |
| vWA-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| TPR-like | LEA14-like | 1 | 1 |  |
| Ribosomal proteins S24e, L23 and L15e | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
| Ribosomal proteins S24e, L23 and L15e | HSP40/DnaJ peptide-binding domain | 1 | 1 |  |
| Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 |  |
| Tudor/PWWP/MBT | DNA repair protein MutS, domain III | 1 | 1 |  |
| DNA-binding domain | Histone-fold | 1 | 1 |  |
| Nucleotidyltransferase | EF-hand | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Macro domain-like | 1 | 1 |  |
| Chromo domain-like | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| Formin homology 2 domain (FH2 domain) | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| Acyl-CoA binding protein | Ran binding protein zinc finger-like | 1 | 1 |  |
| L30e-like | Acid proteases | 1 | 1 |  |
| Multidrug resistance efflux transporter EmrE | Acetyl-CoA synthetase-like | 1 | 1 |  |
| Histone-fold | RNA-binding domain, RBD | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | MurD-like peptide ligases, catalytic domain | 1 | 1 |  |
| RING/U-box | Riboflavin kinase-like | 1 | 1 |  |
| SH3-domain | Cytochrome P450 | 1 | 1 |  |
| Phospholipase D/nuclease | Acid proteases | 1 | 1 |  |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleotidyltransferase | 1 | 1 |  |
| Obg GTP-binding protein N-terminal domain | Obg GTP-binding protein C-terminal domain | 1 | 1 |  |
| FKBP-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| AF0104/ALDC/Ptd012-like | Mannose-binding lectins | 1 | 1 |  |
| CBS-domain pair | Protein kinase-like (PK-like) | 1 | 1 |  |
| GroEL apical domain-like | Galactose mutarotase-like | 1 | 1 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 |  |
| Barwin-like endoglucanases | Protein kinase-like (PK-like) | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | RING/U-box | 1 | 1 |  |
| RNA-binding domain, RBD | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| Ribosomal protein S3 C-terminal domain | Ribosomal protein L16p/L10e | 1 | 1 |  |
| Protein kinase-like (PK-like) | Acyl-CoA dehydrogenase NM domain-like | 1 | 1 |  |
| VC0467-like | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Carbonic anhydrase | Ribonuclease H-like | 1 | 1 |  |
| ARM repeat | Leucine zipper domain | 1 | 1 |  |
| Nucleotidylyl transferase | Alpha-L RNA-binding motif | 1 | 1 |  |
| DNA/RNA polymerases | Kelch motif | 1 | 1 |  |
| Cysteine-rich domain | NAD kinase/diacylglycerol kinase-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | DNA/RNA polymerases | 1 | 1 |  |
| DEK C-terminal domain | ssDNA-binding transcriptional regulator domain | 1 | 1 |  |
| Peptide methionine sulfoxide reductase | Peptide methionine sulfoxide reductase | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Cytochrome P450 | 1 | 1 |  |
| Periplasmic binding protein-like I | Voltage-gated potassium channels | 1 | 1 |  |
| FYSH domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Protein kinase-like (PK-like) | AlbA-like | 1 | 1 |  |
| Cdc48 domain 2-like | Cdc48 domain 2-like | 1 | 1 |  |
| MCP/YpsA-like | MCP/YpsA-like | 1 | 1 |  |
| Cytochrome P450 | TK C-terminal domain-like | 1 | 1 |  |
| Mitochondrial carrier | Trypsin-like serine proteases | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | ClpP/crotonase | 1 | 1 |  |
| Protein kinase-like (PK-like) | Glycosyl hydrolase domain | 1 | 1 |  |
| BRCT domain | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Sigma2 domain of RNA polymerase sigma factors | 1 | 1 |  |
| Growth factor receptor domain | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| FGAM synthase PurL, linker domain | PurM C-terminal domain-like | 1 | 1 |  |
| Homeodomain-like | Ankyrin repeat | 1 | 1 |  |
| WD40 repeat-like | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| RNI-like | alpha/beta knot | 1 | 1 |  |
| Acetyl-CoA synthetase-like | Heme-dependent catalase-like | 1 | 1 |  |
| Leucine zipper domain | TK C-terminal domain-like | 1 | 1 |  |
| Ubiquitin-like | CAD & PB1 domains | 1 | 1 |  |
| Arginase/deacetylase | Six-hairpin glycosidases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Cation efflux protein cytoplasmic domain-like | 1 | 1 |  |
| WD40 repeat-like | CBS-domain pair | 1 | 1 |  |
| ARM repeat | SH3-domain | 1 | 1 |  |
| Chaperone J-domain | Sec63 N-terminal domain-like | 1 | 1 |  |
| Cytochrome f, large domain | Rudiment single hybrid motif | 1 | 1 |  |
| Class II aaRS and biotin synthetases | TPR-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| Carboxypeptidase regulatory domain-like | Cna protein B-type domain | 1 | 1 |  |
| Ribonuclease H-like | BolA-like | 1 | 1 |  |
| RNA-binding domain, RBD | Rhomboid-like | 1 | 1 |  |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 1 | 1 |  |
| Enolase N-terminal domain-like | Enolase N-terminal domain-like | 1 | 1 |  |
| Pectin lyase-like | PHL pollen allergen | 1 | 1 |  |
| FYVE/PHD zinc finger | Growth factor receptor domain | 1 | 1 |  |
| Riboflavin synthase domain-like | Terpenoid synthases | 1 | 1 |  |
| Chaperone J-domain | E set domains | 1 | 1 |  |
| Ribonuclease H-like | At5g01610-like | 1 | 1 |  |
| Cupredoxins | Leucine zipper domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | PLP-dependent transferases | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | RNA-binding domain, RBD | 1 | 1 |  |
| (Trans)glycosidases | SIS domain | 1 | 1 |  |
| E set domains | RNA-binding domain, RBD | 1 | 1 |  |
| NAD kinase/diacylglycerol kinase-like | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Ribosomal protein L32e | Bet v1-like | 1 | 1 |  |
| Glycerol-3-phosphate (1)-acyltransferase | EF-hand | 1 | 1 |  |
| Galactose mutarotase-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| ARM repeat | Zn-dependent exopeptidases | 1 | 1 |  |
| FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) | Protein kinase-like (PK-like) | 1 | 1 |  |
| Creatinase/aminopeptidase | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| Ribonuclease H-like | PH domain-like | 1 | 1 |  |
| Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | Nucleic acid-binding proteins | 1 | 1 |  |
| DNA/RNA polymerases | ClpP/crotonase | 1 | 1 |  |
| Acid proteases | Cupredoxins | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | TRCF domain-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Phosphohistidine domain | 1 | 1 |  |
| SAP domain | RNA-binding domain, RBD | 1 | 1 |  |
| Protein kinase-like (PK-like) | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 1 | 1 |  |
| RING/U-box | Calcium-dependent phosphotriesterase | 1 | 1 |  |
| DNA/RNA polymerases | vWA-like | 1 | 1 |  |
| SNARE fusion complex | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Zn-binding ribosomal proteins | 1 | 1 |  |
| Homeodomain-like | DNase I-like | 1 | 1 |  |
| PP2C-like | Head domain of nucleotide exchange factor GrpE | 1 | 1 |  |
| cAMP-binding domain-like | SpoIIaa-like | 1 | 1 |  |
| PP2C-like | PreATP-grasp domain | 1 | 1 |  |
| Ribonuclease H-like | Sm-like ribonucleoproteins | 1 | 1 |  |
| Succinyl-CoA synthetase domains | Succinyl-CoA synthetase domains | 1 | 1 |  |
| LeuD/IlvD-like | ARM repeat | 1 | 1 |  |
| ARM repeat | Translation proteins | 1 | 1 |  |
| Histone-fold | Carbohydrate phosphatase | 1 | 1 |  |
| Tropomyosin | ISP domain | 1 | 1 |  |
| RmlC-like cupins | Arginase/deacetylase | 1 | 1 |  |
| CRAL/TRIO domain | Homeodomain-like | 1 | 1 |  |
| Molybdenum cofactor biosynthesis proteins | Molybdenum cofactor biosynthesis proteins | 1 | 1 |  |
| HD-domain/PDEase-like | EF-hand | 1 | 1 |  |
| Rudiment single hybrid motif | Rudiment single hybrid motif | 1 | 1 |  |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 1 | 1 |  |
| Rudiment single hybrid motif | Ribosomal L11/L12e N-terminal domain | 1 | 1 |  |
| Amine oxidase N-terminal region | TK C-terminal domain-like | 1 | 1 |  |
| Chaperone J-domain | Homeodomain-like | 1 | 1 |  |
| HSP20-like chaperones | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Molybdenum cofactor biosynthesis proteins | MoeA C-terminal domain-like | 1 | 1 |  |
| RuBisCO, large subunit, small (N-terminal) domain | RuBisCo, C-terminal domain | 1 | 1 |  |
| Chromo domain-like | Ankyrin repeat | 1 | 1 |  |
| LDL receptor-like module | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| Metal cation-transporting ATPase, ATP-binding domain N | L domain-like | 1 | 1 |  |
| BRCT domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | BRCT domain | 1 | 1 |  |
| GroEL apical domain-like | ARID-like | 1 | 1 |  |
| CRAL/TRIO N-terminal domain | Homeodomain-like | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | DHS-like NAD/FAD-binding domain | 1 | 1 |  |
| RecA protein, C-terminal domain | AN1-like Zinc finger | 1 | 1 |  |
| Rhodanese/Cell cycle control phosphatase | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 |  |
| Ammonium transporter | Ammonium transporter | 1 | 1 |  |
| Thiamin pyrophosphokinase, catalytic domain | Thiamin pyrophosphokinase, substrate-binding domain | 1 | 1 |  |
| alpha/beta-Hydrolases | Terpenoid synthases | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | ArfGap/RecO-like zinc finger | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 1 | 1 |  |
| WD40 repeat-like | SBT domain | 1 | 1 |  |
| CBS-domain pair | PABC (PABP) domain | 1 | 1 |  |
| PurM C-terminal domain-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
| Ran binding protein zinc finger-like | DNase I-like | 1 | 1 |  |
| DNA-binding pseudobarrel domain | WD40 repeat-like | 1 | 1 |  |
| UBA-like | CAD & PB1 domains | 1 | 1 |  |
| SNARE-like | Chaperone J-domain | 1 | 1 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | SNARE-like | 1 | 1 |  |
| Chalcone isomerase | Chalcone isomerase | 1 | 1 |  |
| Bet v1-like | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | 1 |  |
| N-terminal domain of adenylylcyclase associated protein, CAP | N-terminal domain of adenylylcyclase associated protein, CAP | 1 | 1 |  |
| PLP-dependent transferases | Actin-like ATPase domain | 1 | 1 |  |
| TPR-like | PUA domain-like | 1 | 1 |  |
| Zinc hairpin stack | RING/U-box | 1 | 1 |  |
| RNA-binding domain, RBD | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
| Protein kinase-like (PK-like) | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 1 | 1 |  |
| PurS-like | PurM C-terminal domain-like | 1 | 1 |  |
| Thioredoxin-like | RING/U-box | 1 | 1 |  |
| Dom34/Pelota N-terminal domain-like | Translational machinery components | 1 | 1 |  |
| Protein kinase-like (PK-like) | Thioredoxin-like | 1 | 1 |  |
| Subtilisin-like | C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | 1 |  |
| Single hybrid motif | ClpP/crotonase | 1 | 1 |  |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| WRKY DNA-binding domain | RNA-binding domain, RBD | 1 | 1 |  |
| DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Acid phosphatase/Vanadium-dependent haloperoxidase | alpha/beta-Hydrolases | 1 | 1 |  |
| R3H domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| PLP-dependent transferases | L30e-like | 1 | 1 |  |
| GST C-terminal domain-like | Nucleic acid-binding proteins | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | SAM/Pointed domain | 1 | 1 |  |
| ACP-like | Trimeric LpxA-like enzymes | 1 | 1 |  |
| PurM N-terminal domain-like | PurM N-terminal domain-like | 1 | 1 |  |
| Type II DNA topoisomerase | GyrA/ParC C-terminal domain-like | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | L domain-like | 1 | 1 |  |
| ValRS/IleRS/LeuRS editing domain | ValRS/IleRS/LeuRS editing domain | 1 | 1 |  |
| GST C-terminal domain-like | Ribosomal protein L25-like | 1 | 1 |  |
| UBC-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Ribosomal protein S10 | CBS-domain pair | 1 | 1 |  |
| F-box domain | SMI1/KNR4-like | 1 | 1 |  |
| SPOC domain-like | C-terminal domain of Ku80 | 1 | 1 |  |
| Ribosomal protein S8 | Ribosomal protein S8 | 1 | 1 |  |
| Actin-like ATPase domain | DNA/RNA polymerases | 1 | 1 |  |
| Six-hairpin glycosidases | DNA-binding domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| Ankyrin repeat | RCC1/BLIP-II | 1 | 1 |  |
| UBA-like | NSFL1 (p97 ATPase) cofactor p47, SEP domain | 1 | 1 |  |
| POZ domain | (Trans)glycosidases | 1 | 1 |  |
| WW domain | CAD & PB1 domains | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Taf5 N-terminal domain-like | 1 | 1 |  |
| AMPKBI-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Cysteine proteinases | Thioredoxin-like | 1 | 1 |  |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | YhbY-like | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | Glycosyl hydrolase domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Rhomboid-like | 1 | 1 |  |
| Mitochondrial carrier | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | MFS general substrate transporter | 1 | 1 |  |
| Protein kinase-like (PK-like) | Cytochrome P450 | 1 | 1 |  |
| SufE/NifU | NadA-like | 1 | 1 |  |
| Starch-binding domain-like | (Trans)glycosidases | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | CRAL/TRIO domain | 1 | 1 |  |
| Zn-dependent exopeptidases | Cyclophilin-like | 1 | 1 |  |
| VHP, Villin headpiece domain | (Trans)glycosidases | 1 | 1 |  |
| RNI-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Radical SAM enzymes | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | beta-beta-alpha zinc fingers | 1 | 1 |  |
| DNA/RNA polymerases | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | RL5-like | 1 | 1 |  |
| Xylose isomerase-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| TrmE connector domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| L domain-like | alpha/beta knot | 1 | 1 |  |
| Tropomyosin | Bet v1-like | 1 | 1 |  |
| PRC-barrel domain | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| (Trans)glycosidases | NAC domain | 1 | 1 |  |
| Nudix | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| Histone-fold | Histidine-containing phosphotransfer domain, HPT domain | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | NAC domain | 1 | 1 |  |
| PUA domain-like | SWIB/MDM2 domain | 1 | 1 |  |
| AlbA-like | SNARE-like | 1 | 1 |  |
| Ran binding protein zinc finger-like | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| WRKY DNA-binding domain | FtsH protease domain-like | 1 | 1 |  |
| Histone-fold | Ribosomal protein S8 | 1 | 1 |  |
| Nucleic acid-binding proteins | BRCT domain | 1 | 1 |  |
| SWIB/MDM2 domain | RING/U-box | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | TRAF domain-like | 1 | 1 |  |
| ARM repeat | Zinc beta-ribbon | 1 | 1 |  |
| WD40 repeat-like | GroEL equatorial domain-like | 1 | 1 |  |
| Thiolase-like | RNI-like | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | HAD-like | 1 | 1 |  |
| Carbamate kinase-like | ARM repeat | 1 | 1 |  |
| Galactose-binding domain-like | Retrovirus zinc finger-like domains | 1 | 1 |  |
| DNA/RNA polymerases | BolA-like | 1 | 1 |  |
| PH domain-like | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
| GST C-terminal domain-like | HMA, heavy metal-associated domain | 1 | 1 |  |
| WD40 repeat-like | NAC domain | 1 | 1 |  |
| Cysteine proteinases | FYVE/PHD zinc finger | 1 | 1 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | ABC transporter transmembrane region | 1 | 1 |  |
| Galactose mutarotase-like | L domain-like | 1 | 1 |  |
| RNA-binding domain, RBD | DPP6 N-terminal domain-like | 1 | 1 |  |
| ARM repeat | TRAP-like | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Homeodomain-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | LuxS/MPP-like metallohydrolase | 1 | 1 |  |
| WD40 repeat-like | NHL repeat | 1 | 1 |  |
| Clavaminate synthase-like | HSP40/DnaJ peptide-binding domain | 1 | 1 |  |
| AlbA-like | Nqo1C-terminal domain-like | 1 | 1 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | Acetyl-CoA synthetase-like | 1 | 1 |  |
| (Trans)glycosidases | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| RNI-like | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| Class II aaRS ABD-related | Bet v1-like | 1 | 1 |  |
| RING/U-box | DNA-binding domain | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| SAP domain | Kelch motif | 1 | 1 |  |
| NSFL1 (p97 ATPase) cofactor p47, SEP domain | CAD & PB1 domains | 1 | 1 |  |
| Cysteine proteinases | Tudor/PWWP/MBT | 1 | 1 |  |
| TAZ domain | TAZ domain | 1 | 1 |  |
| Bet v1-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| RNI-like | FYVE/PHD zinc finger | 1 | 1 |  |
| ARM repeat | SMAD/FHA domain | 1 | 1 |  |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | Metallo-dependent phosphatases | 1 | 1 |  |
| F1F0 ATP synthase subunit C | N-terminal domain of alpha and beta subunits of F1 ATP synthase | 1 | 1 |  |
| Acetyl-CoA synthetase-like | 4Fe-4S ferredoxins | 1 | 1 |  |
| Ribosomal protein S16 | Osmotin, thaumatin-like protein | 1 | 1 |  |
| Thioredoxin-like | FAD-dependent thiol oxidase | 1 | 1 |  |
| EF-hand | RNI-like | 1 | 1 |  |
| TK C-terminal domain-like | alpha/beta-Hydrolases | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Multidrug resistance efflux transporter EmrE | 1 | 1 |  |
| ClpP/crotonase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Heme-dependent peroxidases | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| HMA, heavy metal-associated domain | (Trans)glycosidases | 1 | 1 |  |
| Lipoxigenase | YhbY-like | 1 | 1 |  |
| MIR domain | MIR domain | 1 | 1 |  |
| RING/U-box | POZ domain | 1 | 1 |  |
| Phosphoglycerate mutase-like | DNA/RNA polymerases | 1 | 1 |  |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| GroEL equatorial domain-like | GroEL equatorial domain-like | 1 | 1 |  |
| Functional domain of the splicing factor Prp18 | Functional domain of the splicing factor Prp18 | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | EF-hand | 1 | 1 |  |
| POZ domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| ENTH/VHS domain | Ubiquitin-like | 1 | 1 |  |
| Ribokinase-like | Nucleic acid-binding proteins | 1 | 1 |  |
| PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 |  |
| FAD-linked reductases, C-terminal domain | FAD-linked reductases, C-terminal domain | 1 | 1 |  |
| DNA/RNA polymerases | Cyclophilin-like | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | F-box domain | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | PLP-dependent transferases | 1 | 1 |  |
| LEA14-like | FYVE/PHD zinc finger | 1 | 1 |  |
| FAD-dependent thiol oxidase | RNA-binding domain, RBD | 1 | 1 |  |
| Leucine zipper domain | Aldolase | 1 | 1 |  |
| ARM repeat | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 1 | 1 |  |
| RNA-binding domain, RBD | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| FYSH domain | Hypothetical protein AF0491, middle domain | 1 | 1 |  |
| ClpP/crotonase | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| Nucleic acid-binding proteins | Ribosomal protein L16p/L10e | 1 | 1 |  |
| "Winged helix" DNA-binding domain | HRDC-like | 1 | 1 |  |
| ARM repeat | Tricorn protease domain 2 | 1 | 1 |  |
| Class II aaRS ABD-related | Protein kinase-like (PK-like) | 1 | 1 |  |
| Rhomboid-like | Annexin | 1 | 1 |  |
| FAD/NAD(P)-binding domain | 4Fe-4S ferredoxins | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | HIT/MYND zinc finger-like | 1 | 1 |  |
| Hypothetical protein AF0491, middle domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| E2F-DP heterodimerization region | Retrovirus zinc finger-like domains | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Thiamin pyrophosphokinase, catalytic domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Thiamin pyrophosphokinase, substrate-binding domain | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Glutathione synthetase ATP-binding domain-like | 1 | 1 |  |
| HydA/Nqo6-like | EF-hand | 1 | 1 |  |
| Homeodomain-like | YVTN repeat-like/Quinoprotein amine dehydrogenase | 1 | 1 |  |
| Protein kinase-like (PK-like) | Nudix | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Mitochondrial glycoprotein MAM33-like | 1 | 1 |  |
| WD40 repeat-like | Phosphoglycerate mutase-like | 1 | 1 |  |
| alpha-D-mannose-specific plant lectins | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Domain of the SRP/SRP receptor G-proteins | Signal peptide-binding domain | 1 | 1 |  |
| Phosphoglycerate kinase | Phosphoglycerate kinase | 1 | 1 |  |
| Probable bacterial effector-binding domain | Homeodomain-like | 1 | 1 |  |
| SurE-like | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| DNA/RNA polymerases | Tetrahydrobiopterin biosynthesis enzymes-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Calcium ATPase, transmembrane domain M | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | Nucleic acid-binding proteins | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Microbial and mitochondrial ADK, insert "zinc finger" domain | 1 | 1 |  |
| Leucine zipper domain | Ribosomal protein L16p/L10e | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | GroES-like | 1 | 1 |  |
| POZ domain | Retrovirus zinc finger-like domains | 1 | 1 |  |
| L domain-like | Zn-binding ribosomal proteins | 1 | 1 |  |
| HMA, heavy metal-associated domain | 2Fe-2S ferredoxin-like | 1 | 1 |  |
| Metallo-dependent hydrolases | Six-hairpin glycosidases | 1 | 1 |  |
| SSo0622-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| PurS-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
| WRKY DNA-binding domain | Chalcone isomerase | 1 | 1 |  |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | alpha/beta knot | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| ARM repeat | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| RmlC-like cupins | Hypothetical protein YjiA, C-terminal domain | 1 | 1 |  |
| Class II aaRS and biotin synthetases | GAD domain-like | 1 | 1 |  |
| Class II aaRS and biotin synthetases | Bet v1-like | 1 | 1 |  |
| 4Fe-4S ferredoxins | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| F-box domain | Clavaminate synthase-like | 1 | 1 |  |
| AN1-like Zinc finger | AN1-like Zinc finger | 1 | 1 |  |
| Peptidyl-tRNA hydrolase-like | Peptidyl-tRNA hydrolase-like | 1 | 1 |  |
| Nucleic acid-binding proteins | GAD domain-like | 1 | 1 |  |
| Homeodomain-like | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Purple acid phosphatase, N-terminal domain | Purple acid phosphatase, N-terminal domain | 1 | 1 |  |
| Aquaporin-like | Ribonuclease H-like | 1 | 1 |  |
| (Trans)glycosidases | SNARE-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| HAD-like | Ypt/Rab-GAP domain of gyp1p | 1 | 1 |  |
| Protein kinase-like (PK-like) | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| Sm-like ribonucleoproteins | Protein kinase-like (PK-like) | 1 | 1 |  |
| RL5-like | L30e-like | 1 | 1 |  |
| Nucleic acid-binding proteins | TPR-like | 1 | 1 |  |
| WW domain | EF-hand | 1 | 1 |  |
| PLP-dependent transferases | F-box domain | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Kelch motif | 1 | 1 |  |
| HAD-like | Histone-fold | 1 | 1 |  |
| GAT-like domain | SET domain | 1 | 1 |  |
| FAD-linked oxidoreductase | Actin depolymerizing proteins | 1 | 1 |  |
| ARM repeat | Cyclophilin-like | 1 | 1 |  |
| PLC-like phosphodiesterases | BAR/IMD domain-like | 1 | 1 |  |
| Ribonuclease H-like | WD40 repeat-like | 1 | 1 |  |
| HMG-box | Zn-dependent exopeptidases | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | S-adenosylmethionine synthetase | 1 | 1 |  |
| Succinyl-CoA synthetase domains | S-adenosylmethionine synthetase | 1 | 1 |  |
| Thioredoxin-like | Translation proteins | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 |  |
| CAD & PB1 domains | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| (Trans)glycosidases | Cyclin-like | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | Argininosuccinate synthetase, C-terminal domain | 1 | 1 |  |
| Metalloproteases ("zincins"), catalytic domain | Frizzled cysteine-rich domain | 1 | 1 |  |
| Bacterial exopeptidase dimerisation domain | Cyclophilin-like | 1 | 1 |  |
| Leucine zipper domain | Cytochrome P450 | 1 | 1 |  |
| Calponin-homology domain, CH-domain | WD40 repeat-like | 1 | 1 |  |
| SMAD/FHA domain | Phospholipase D/nuclease | 1 | 1 |  |
| Protein kinase-like (PK-like) | CCCH zinc finger | 1 | 1 |  |
| CHY zinc finger-like | RING/U-box | 1 | 1 |  |
| alpha/beta-Hydrolases | Ankyrin repeat | 1 | 1 |  |
| L-aspartase-like | L-aspartase-like | 1 | 1 |  |
| Eukaryotic type KH-domain (KH-domain type I) | beta-beta-alpha zinc fingers | 1 | 1 |  |
| HSP20-like chaperones | HSP20-like chaperones | 1 | 1 |  |
| Acid proteases | (Trans)glycosidases | 1 | 1 |  |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | EF-hand | 1 | 1 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | Soluble quinoprotein glucose dehydrogenase | 1 | 1 |  |
| ACT-like | WD40 repeat-like | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | RNA-binding domain, RBD | 1 | 1 |  |
| AlbA-like | Thioredoxin-like | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | LuxS/MPP-like metallohydrolase | 1 | 1 |  |
| ARM repeat | PLP-dependent transferases | 1 | 1 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | CRAL/TRIO N-terminal domain | 1 | 1 |  |
| WD40 repeat-like | EF-hand | 1 | 1 |  |
| Nudix | Leucine zipper domain | 1 | 1 |  |
| HesB-like domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| WD40 repeat-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| FKBP-like | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| Nudix | AlbA-like | 1 | 1 |  |
| Cullin repeat-like | PR-1-like | 1 | 1 |  |
| (Trans)glycosidases | JAB1/MPN domain | 1 | 1 |  |
| Actin-like ATPase domain | GroES-like | 1 | 1 |  |
| Ubiquitin-like | Preprotein translocase SecY subunit | 1 | 1 |  |
| EGF/Laminin | EGF/Laminin | 1 | 1 |  |
| FYVE/PHD zinc finger | Plus3-like | 1 | 1 |  |
| WD40 repeat-like | L35p-like | 1 | 1 |  |
| Retrovirus zinc finger-like domains | RING/U-box | 1 | 1 |  |
| vWA-like | HAD-like | 1 | 1 |  |
| Phosphoglycerate mutase-like | PHP domain-like | 1 | 1 |  |
| Skp1 dimerisation domain-like | L domain-like | 1 | 1 |  |
| Thioredoxin-like | Glycosyl hydrolase domain | 1 | 1 |  |
| UBA-like | post-AAA+ oligomerization domain-like | 1 | 1 |  |
| RNA-binding domain, RBD | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | YgbK-like | 1 | 1 |  |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | ACT-like | 1 | 1 |  |
| E set domains | HIT/MYND zinc finger-like | 1 | 1 |  |
| Tudor/PWWP/MBT | FYVE/PHD zinc finger | 1 | 1 |  |
| "Winged helix" DNA-binding domain | Retrovirus zinc finger-like domains | 1 | 1 |  |
| PUA domain-like | alpha-D-mannose-specific plant lectins | 1 | 1 |  |
| GroEL equatorial domain-like | Ribonuclease H-like | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | Nucleotidyltransferase | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | JAB1/MPN domain | 1 | 1 |  |
| Phosphoenolpyruvate/pyruvate domain | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | Calcium ATPase, transmembrane domain M | 1 | 1 |  |
| L-aspartase-like | Homeodomain-like | 1 | 1 |  |
| L30e-like | L30e-like | 1 | 1 |  |
| Clavaminate synthase-like | Pectin lyase-like | 1 | 1 |  |
| LDH C-terminal domain-like | LDH C-terminal domain-like | 1 | 1 |  |
| SIS domain | WD40 repeat-like | 1 | 1 |  |
| WW domain | TPR-like | 1 | 1 |  |
| Amine oxidase catalytic domain | Thiamin diphosphate-binding fold (THDP-binding) | 1 | 1 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | Enolase N-terminal domain-like | 1 | 1 |  |
| F-box domain | FAD-linked reductases, C-terminal domain | 1 | 1 |  |
| YrdC/RibB | YrdC/RibB | 1 | 1 |  |
| Activating enzymes of the ubiquitin-like proteins | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| WW domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Starch-binding domain-like | Starch-binding domain-like | 1 | 1 |  |
| HIT-like | HIT-like | 1 | 1 |  |
| HSP40/DnaJ peptide-binding domain | Chalcone isomerase | 1 | 1 |  |
| Surp module (SWAP domain) | ENTH/VHS domain | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | Bromodomain | 1 | 1 |  |
| Thioredoxin-like | Clavaminate synthase-like | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Mss4-like | 1 | 1 |  |
| AF0104/ALDC/Ptd012-like | Ribosomal protein S10 | 1 | 1 |  |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | Acid proteases | 1 | 1 |  |
| Class I glutamine amidotransferase-like | Ribulose-phoshate binding barrel | 1 | 1 |  |
| Calcium-dependent phosphotriesterase | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| ATP synthase (F1-ATPase), gamma subunit | Riboflavin synthase domain-like | 1 | 1 |  |
| Heme-dependent peroxidases | DNA/RNA polymerases | 1 | 1 |  |
| PreATP-grasp domain | Methylglyoxal synthase-like | 1 | 1 |  |
| DNA primase core | CRAL/TRIO N-terminal domain | 1 | 1 |  |
| PLP-binding barrel | PLP-binding barrel | 1 | 1 |  |
| Cyclophilin-like | RNA-binding domain, RBD | 1 | 1 |  |
| Protein kinase-like (PK-like) | PLP-dependent transferases | 1 | 1 |  |
| PR-1-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| E set domains | E set domains | 1 | 1 |  |
| Actin depolymerizing proteins | CBS-domain pair | 1 | 1 |  |
| Nop10-like SnoRNP | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| 14-3-3 protein | Protein kinase-like (PK-like) | 1 | 1 |  |
| Clavaminate synthase-like | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
| CRAL/TRIO domain | PUA domain-like | 1 | 1 |  |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | D-aminoacid aminotransferase-like PLP-dependent enzymes | 1 | 1 |  |
| UBA-like | Ribonuclease H-like | 1 | 1 |  |
| RNI-like | Radical SAM enzymes | 1 | 1 |  |
| Formyltransferase | Ribonuclease H-like | 1 | 1 |  |
| 14-3-3 protein | UBC-like | 1 | 1 |  |
| Heme-dependent peroxidases | L30e-like | 1 | 1 |  |
| Thioredoxin-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Cysteine proteinases | E set domains | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Trimeric LpxA-like enzymes | 1 | 1 |  |
| HAD-like | Six-hairpin glycosidases | 1 | 1 |  |
| Acyl-CoA binding protein | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | WRKY DNA-binding domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Glycerol-3-phosphate (1)-acyltransferase | 1 | 1 |  |
| Protein kinase-like (PK-like) | GroEL equatorial domain-like | 1 | 1 |  |
| HMA, heavy metal-associated domain | Glycosyl hydrolase domain | 1 | 1 |  |
| RING/U-box | DNase I-like | 1 | 1 |  |
| (Trans)glycosidases | PP2C-like | 1 | 1 |  |
| RNA-binding domain, RBD | GroES-like | 1 | 1 |  |
| CBS-domain pair | Cysteine proteinases | 1 | 1 |  |
| Thiolase-like | L domain-like | 1 | 1 |  |
| Chelatase | Chlorophyll a-b binding protein | 1 | 1 |  |
| Di-copper centre-containing domain | DNA/RNA polymerases | 1 | 1 |  |
| Protein kinase-like (PK-like) | t-snare proteins | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | AF0104/ALDC/Ptd012-like | 1 | 1 |  |
| ArfGap/RecO-like zinc finger | SNARE-like | 1 | 1 |  |
| Metallo-dependent hydrolases | Ribonuclease H-like | 1 | 1 |  |
| Thioredoxin-like | (Trans)glycosidases | 1 | 1 |  |
| L domain-like | 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) | 1 | 1 |  |
| Cu,Zn superoxide dismutase-like | Chaperone J-domain | 1 | 1 |  |
| Putative isomerase YbhE | DNase I-like | 1 | 1 |  |
| Aldolase | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| FabD/lysophospholipase-like | HCP-like | 1 | 1 |  |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | DNA/RNA polymerases | 1 | 1 |  |
| Carbohydrate phosphatase | Apolipoprotein A-I | 1 | 1 |  |
| HD-domain/PDEase-like | alpha/beta-Hydrolases | 1 | 1 |  |
| MAL13P1.257-like | Bacterial exopeptidase dimerisation domain | 1 | 1 |  |
| (Trans)glycosidases | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| Rad51 N-terminal domain-like | FYVE/PHD zinc finger | 1 | 1 |  |
| FYVE/PHD zinc finger | Clavaminate synthase-like | 1 | 1 |  |
| Ribosomal protein L1 | Ribonuclease H-like | 1 | 1 |  |
| beta-Galactosidase/glucuronidase domain | beta-Galactosidase/glucuronidase domain | 1 | 1 |  |
| P-domain of calnexin/calreticulin | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Radical SAM enzymes | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| Tubby C-terminal domain-like | Prokaryotic ribosomal protein L17 | 1 | 1 |  |
| F-box domain | ApaG-like | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Protein kinase-like (PK-like) | 1 | 1 |  |
| Translation proteins | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| EPT/RTPC-like | EPT/RTPC-like | 1 | 1 |  |
| beta-beta-alpha zinc fingers | CCCH zinc finger | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | WD40 repeat-like | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | (Trans)glycosidases | 1 | 1 |  |
| Ribosomal protein S10 | Subtilisin-like | 1 | 1 |  |
| SAICAR synthase-like | RING/U-box | 1 | 1 |  |
| Clavaminate synthase-like | RNI-like | 1 | 1 |  |
| Acid proteases | Thioredoxin-like | 1 | 1 |  |
| GYF domain | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| F-box domain | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| DnaJ/Hsp40 cysteine-rich domain | alpha/beta-Hydrolases | 1 | 1 |  |
| Eukaryotic type KH-domain (KH-domain type I) | Sm-like ribonucleoproteins | 1 | 1 |  |
| L-aspartase-like | Class II aaRS and biotin synthetases | 1 | 1 |  |
| Acetyl-CoA synthetase-like | Trimeric LpxA-like enzymes | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | FabD/lysophospholipase-like | 1 | 1 |  |
| UBC-like | Histone-fold | 1 | 1 |  |
| SBT domain | (Trans)glycosidases | 1 | 1 |  |
| Leucine zipper domain | alpha/beta-Hydrolases | 1 | 1 |  |
| Creatinase/aminopeptidase | Histone-fold | 1 | 1 |  |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | PRTase-like | 1 | 1 |  |
| ARM repeat | Bacterial exopeptidase dimerisation domain | 1 | 1 |  |
| DAK1/DegV-like | DhaL-like | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Chromo domain-like | 1 | 1 |  |
| Pre-protein crosslinking domain of SecA | Retrovirus zinc finger-like domains | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | (Trans)glycosidases | 1 | 1 |  |
| Cyclophilin-like | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
| NAC domain | PEBP-like | 1 | 1 |  |
| BAH domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| WRKY DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Tubby C-terminal domain-like | LEA14-like | 1 | 1 |  |
| DNA/RNA polymerases | Trimeric LpxA-like enzymes | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Actin-crosslinking proteins | 1 | 1 |  |
| MurCD N-terminal domain | MurD-like peptide ligases, catalytic domain | 1 | 1 |  |
| E set domains | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Acid phosphatase/Vanadium-dependent haloperoxidase | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| Pectin lyase-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Leucine zipper domain | RCC1/BLIP-II | 1 | 1 |  |
| beta-lactamase/transpeptidase-like | beta-lactamase/transpeptidase-like | 1 | 1 |  |
| Barwin-like endoglucanases | DPP6 N-terminal domain-like | 1 | 1 |  |
| EF-hand | Homeodomain-like | 1 | 1 |  |
| Rad51 N-terminal domain-like | ARID-like | 1 | 1 |  |
| BAR/IMD domain-like | Cytochrome P450 | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | GIY-YIG endonuclease | 1 | 1 |  |
| V-type ATP synthase subunit C | V-type ATP synthase subunit C | 1 | 1 |  |
| alpha-helical ferredoxin | Acetyl-CoA synthetase-like | 1 | 1 |  |
| LysM domain | Ubiquitin-like | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | CCCH zinc finger | 1 | 1 |  |
| Carbonic anhydrase | Carbonic anhydrase | 1 | 1 |  |
| Homeodomain-like | Mitochondrial carrier | 1 | 1 |  |
| Prokaryotic type KH domain (KH-domain type II) | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 |  |
| BRCT domain | Lesion bypass DNA polymerase (Y-family), little finger domain | 1 | 1 |  |
| EF-hand | TPR-like | 1 | 1 |  |
| F-box domain | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| Ankyrin repeat | HIT/MYND zinc finger-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | SET domain | 1 | 1 |  |
| TPR-like | RNI-like | 1 | 1 |  |
| HAD-like | MFS general substrate transporter | 1 | 1 |  |
| GHMP Kinase, C-terminal domain | GHMP Kinase, C-terminal domain | 1 | 1 |  |
| Functional domain of the splicing factor Prp18 | Cupredoxins | 1 | 1 |  |
| AraD/HMP-PK domain-like | HAD-like | 1 | 1 |  |
| Aminoacid dehydrogenase-like, N-terminal domain | ARM repeat | 1 | 1 |  |
| ARM repeat | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | 1 |  |
| PLP-dependent transferases | FYVE/PHD zinc finger | 1 | 1 |  |
| Cap-Gly domain | Ribonuclease H-like | 1 | 1 |  |
| Riboflavin synthase domain-like | Riboflavin synthase domain-like | 1 | 1 |  |
| TATA-box binding protein-like | DNA-glycosylase | 1 | 1 |  |
| Ribonuclease H-like | HAD-like | 1 | 1 |  |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | Retrovirus zinc finger-like domains | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | ACP-like | 1 | 1 |  |
| Ran binding protein zinc finger-like | Nudix | 1 | 1 |  |
| Homeodomain-like | Nop domain | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Six-hairpin glycosidases | 1 | 1 |  |
| Aquaporin-like | ACT-like | 1 | 1 |  |
| Class I glutamine amidotransferase-like | ADC synthase | 1 | 1 |  |
| PP2C-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | alpha/beta-Hydrolases | 1 | 1 |  |
| Calpain large subunit, middle domain (domain III) | TAZ domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | CRAL/TRIO N-terminal domain | 1 | 1 |  |
| SNARE-like | PRTase-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | beta-lactamase/transpeptidase-like | 1 | 1 |  |
| Cysteine proteinases | Periplasmic binding protein-like II | 1 | 1 |  |
| SNARE fusion complex | PH domain-like | 1 | 1 |  |
| RNA-binding domain, RBD | Nucleic acid-binding proteins | 1 | 1 |  |
| Bet v1-like | Hect, E3 ligase catalytic domain | 1 | 1 |  |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 1 | 1 |  |
| "Winged helix" DNA-binding domain | Saposin | 1 | 1 |  |
| Zn-dependent exopeptidases | MFS general substrate transporter | 1 | 1 |  |
| Periplasmic binding protein-like II | Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | 1 |  |
| RNA-binding domain, RBD | Ribonuclease PH domain 2-like | 1 | 1 |  |
| Tubulin C-terminal domain-like | Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) | 1 | 1 |  |
| ClpP/crotonase | Ribosomal protein L7/12, oligomerisation (N-terminal) domain | 1 | 1 |  |
| Cyclophilin-like | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | Six-hairpin glycosidases | 1 | 1 |  |
| SufE/NifU | BolA-like | 1 | 1 |  |
| Chaperone J-domain | RNA-binding domain, RBD | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Clathrin adaptor appendage domain | 1 | 1 |  |
| GroEL apical domain-like | Cysteine proteinases | 1 | 1 |  |
| PP2C-like | Outer arm dynein light chain 1 | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | NAD(P)-linked oxidoreductase | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Nucleotide-binding domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| Ribonuclease H-like | Terpenoid synthases | 1 | 1 |  |
| Ribosomal protein L22 | Tetrahydrobiopterin biosynthesis enzymes-like | 1 | 1 |  |
| NAD kinase/diacylglycerol kinase-like | DNA-binding pseudobarrel domain | 1 | 1 |  |
| WD40 repeat-like | Zn-binding ribosomal proteins | 1 | 1 |  |
| Cryptochrome/photolyase, N-terminal domain | alpha/beta-Hydrolases | 1 | 1 |  |
| Cell cycle regulatory proteins | Cell cycle regulatory proteins | 1 | 1 |  |
| PUA domain-like | eIF1-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | DNA-binding domain | 1 | 1 |  |
| AlbA-like | AlbA-like | 1 | 1 |  |
| Prefoldin | PR-1-like | 1 | 1 |  |
| HAD-like | YrdC/RibB | 1 | 1 |  |
| UBA-like | Preprotein translocase SecY subunit | 1 | 1 |  |
| SRF-like | (Trans)glycosidases | 1 | 1 |  |
| RING/U-box | Bacterial exopeptidase dimerisation domain | 1 | 1 |  |
| Metallo-dependent hydrolases | Protein kinase-like (PK-like) | 1 | 1 |  |
| ARM repeat | Clavaminate synthase-like | 1 | 1 |  |
| RNA-binding domain, RBD | Ribonuclease H-like | 1 | 1 |  |
| Profilin (actin-binding protein) | Protein kinase-like (PK-like) | 1 | 1 |  |
| PH domain-like | BSD domain-like | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| SMI1/KNR4-like | ApaG-like | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | 1 |  |
| PX domain | BAR/IMD domain-like | 1 | 1 |  |
| PA domain | SpoIIaa-like | 1 | 1 |  |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Actin depolymerizing proteins | 1 | 1 |  |
| Ribonuclease Rh-like | Ribonuclease Rh-like | 1 | 1 |  |
| Ankyrin repeat | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S7 | 1 | 1 |  |
| Transthyretin (synonym: prealbumin) | ClpP/crotonase | 1 | 1 |  |
| Bet v1-like | Multidrug resistance efflux transporter EmrE | 1 | 1 |  |
| E2F-DP heterodimerization region | RNA-binding domain, RBD | 1 | 1 |  |
| DNase I-like | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| t-snare proteins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 |  |
| Ribosomal protein L30p/L7e | Ribosomal protein L30p/L7e | 1 | 1 |  |
| ClpS-like | RCC1/BLIP-II | 1 | 1 |  |
| CRAL/TRIO N-terminal domain | Sec1/munc18-like (SM) proteins | 1 | 1 |  |
| beta-carbonic anhydrase, cab | UBC-like | 1 | 1 |  |
| Phosphofructokinase | "Winged helix" DNA-binding domain | 1 | 1 |  |
| ABC transporter transmembrane region | Ribonuclease H-like | 1 | 1 |  |
| Actin depolymerizing proteins | (Trans)glycosidases | 1 | 1 |  |
| Arginase/deacetylase | alpha/beta-Hydrolases | 1 | 1 |  |
| FAD/NAD(P)-binding domain | FMN-binding split barrel | 1 | 1 |  |
| Nucleotide-binding domain | Acetyl-CoA synthetase-like | 1 | 1 |  |
| 5' to 3' exonuclease, C-terminal subdomain | C-terminal autoproteolytic domain of nucleoporin nup98 | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | DNA/RNA polymerases | 1 | 1 |  |
| Phospholipase C/P1 nuclease | Phospholipase C/P1 nuclease | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Ribonuclease H-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | NHL repeat | 1 | 1 |  |
| eIF-2-alpha, C-terminal domain | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| Translation proteins | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Nucleic acid-binding proteins | Osmotin, thaumatin-like protein | 1 | 1 |  |
| WD40 repeat-like | Soluble quinoprotein glucose dehydrogenase | 1 | 1 |  |
| IlvD/EDD N-terminal domain-like | LeuD/IlvD-like | 1 | 1 |  |
| Actin depolymerizing proteins | POZ domain | 1 | 1 |  |
| ssDNA-binding transcriptional regulator domain | LexA/Signal peptidase | 1 | 1 |  |
| 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 1 | 1 |  |
| PurM N-terminal domain-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
| Nucleic acid-binding proteins | FAS1 domain | 1 | 1 |  |
| (Trans)glycosidases | CRAL/TRIO domain | 1 | 1 |  |
| SIS domain | CBS-domain pair | 1 | 1 |  |
| PYP-like sensor domain (PAS domain) | CheY-like | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | 4Fe-4S ferredoxins | 1 | 1 |  |
| RING/U-box | Mitochondrial carrier | 1 | 1 |  |
| YjeF N-terminal domain-like | FMN-binding split barrel | 1 | 1 |  |
| Ankyrin repeat | Translation proteins | 1 | 1 |  |
| RmlC-like cupins | L domain-like | 1 | 1 |  |
| At5g01610-like | Voltage-gated potassium channels | 1 | 1 |  |
| Terpenoid cyclases/Protein prenyltransferases | DNA/RNA polymerases | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Ribonuclease H-like | 1 | 1 |  |
| beta-beta-alpha zinc fingers | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Families 57/38 glycoside transferase middle domain | SGNH hydrolase | 1 | 1 |  |
| Bet v1-like | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| Ribonuclease H-like | CoA-dependent acyltransferases | 1 | 1 |  |
| Voltage-gated potassium channels | Ribonuclease H-like | 1 | 1 |  |
| PIN domain-like | Nucleic acid-binding proteins | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Thioredoxin-like | Ribulose-phoshate binding barrel | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | Thioesterase/thiol ester dehydrase-isomerase | 1 | 1 |  |
| Cupredoxins | Cysteine proteinases | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | beta-sandwich domain of Sec23/24 | 1 | 1 |  |
| HSP20-like chaperones | Ribonuclease H-like | 1 | 1 |  |
| Pectin lyase-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Protein kinase-like (PK-like) | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Ribosomal protein S8 | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Subunits of heterodimeric actin filament capping protein Capz | Subunits of heterodimeric actin filament capping protein Capz | 1 | 1 |  |
| Alanine racemase C-terminal domain-like | Dihydrofolate reductase-like | 1 | 1 |  |
| Double-stranded DNA-binding domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| DNase I-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Metallo-dependent phosphatases | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| L domain-like | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| WD40 repeat-like | Heme-dependent peroxidases | 1 | 1 |  |
| ENTH/VHS domain | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Mannose-binding lectins | 1 | 1 |  |
| Thioredoxin-like | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| NAC domain | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| vWA-like | Riboflavin kinase-like | 1 | 1 |  |
| Nitrous oxide reductase, N-terminal domain | WD40 repeat-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 1 | 1 |  |
| Ribosomal protein S8 | UBC-like | 1 | 1 |  |
| TPR-like | ENTH/VHS domain | 1 | 1 |  |
| PRTase-like | PapD-like | 1 | 1 |  |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | Terpenoid synthases | 1 | 1 |  |
| RNA-binding domain, RBD | PUA domain-like | 1 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | WGR domain-like | 1 | 1 |  |
| Zinc-binding domain of translation initiation factor 2 beta | ClpP/crotonase | 1 | 1 |  |
| Cytidine deaminase-like | YbiA-like | 1 | 1 |  |
| F-box domain | Radical SAM enzymes | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Rubredoxin-like | 1 | 1 |  |
| t-snare proteins | t-snare proteins | 1 | 1 |  |
| Skp1 dimerisation domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| PLP-dependent transferases | BRCT domain | 1 | 1 |  |
| DNA-binding domain | alpha/beta-Hydrolases | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Subtilisin-like | 1 | 1 |  |
| WRKY DNA-binding domain | CCCH zinc finger | 1 | 1 |  |
| RNI-like | Chlorophyll a-b binding protein | 1 | 1 |  |
| Mechanosensitive channel protein MscS (YggB), transmembrane region | Sm-like ribonucleoproteins | 1 | 1 |  |
| FGAM synthase PurL, linker domain | PurM N-terminal domain-like | 1 | 1 |  |
| PRP4-like | WD40 repeat-like | 1 | 1 |  |
| Nucleotidyltransferase | Cyclin-like | 1 | 1 |  |
| DNA/RNA polymerases | C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | 1 |  |
| TK C-terminal domain-like | Soluble quinoprotein glucose dehydrogenase | 1 | 1 |  |
| 4Fe-4S ferredoxins | Formate dehydrogenase/DMSO reductase, domains 1-3 | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| ARM repeat | DNA-binding domain | 1 | 1 |  |
| Hypothetical protein YjiA, C-terminal domain | Homeodomain-like | 1 | 1 |  |
| MAPEG domain-like | Ribonuclease H-like | 1 | 1 |  |
| RNA-binding domain, RBD | Acid proteases | 1 | 1 |  |
| Acid proteases | HMA, heavy metal-associated domain | 1 | 1 |  |
| Nucleotide-diphospho-sugar transferases | Cyclin-like | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | Actin-like ATPase domain | 1 | 1 |  |
| TPR-like | Rhodanese/Cell cycle control phosphatase | 1 | 1 |  |
| DNA/RNA polymerases | GAT-like domain | 1 | 1 |  |
| L domain-like | Translation proteins SH3-like domain | 1 | 1 |  |
| Chaperone J-domain | Chalcone isomerase | 1 | 1 |  |
| Rudiment single hybrid motif | N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 1 | 1 |  |
| Galactose mutarotase-like | UBC-like | 1 | 1 |  |
| Carbohydrate phosphatase | Carbohydrate phosphatase | 1 | 1 |  |
| Homeodomain-like | UBC-like | 1 | 1 |  |
| eIF2alpha middle domain-like | HLH, helix-loop-helix DNA-binding domain | 1 | 1 |  |
| HLH, helix-loop-helix DNA-binding domain | DNA-binding domain | 1 | 1 |  |
| post-AAA+ oligomerization domain-like | Acid proteases | 1 | 1 |  |
| E set domains | Homeodomain-like | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Retrovirus zinc finger-like domains | 1 | 1 |  |
| Terpenoid synthases | Retrovirus zinc finger-like domains | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | Heme-dependent peroxidases | 1 | 1 |  |
| ENTH/VHS domain | SET domain | 1 | 1 |  |
| Ribonuclease H-like | GAT-like domain | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| PRTase-like | Ribulose-phoshate binding barrel | 1 | 1 |  |
| RNA-binding domain, RBD | (Trans)glycosidases | 1 | 1 |  |
| FtsH protease domain-like | FAS1 domain | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | Terpenoid synthases | 1 | 1 |  |
| PHP domain-like | PHP domain-like | 1 | 1 |  |
| Poly A polymerase C-terminal region-like | Cyclin-like | 1 | 1 |  |
| F-box domain | Cytochrome b5-like heme/steroid binding domain | 1 | 1 |  |
| Ubiquitin-like | Heme-dependent peroxidases | 1 | 1 |  |
| HAD-like | beta-beta-alpha zinc fingers | 1 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | S13-like H2TH domain | 1 | 1 |  |
| SRF-like | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| Phosphoglycerate mutase-like | Homeodomain-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | YgbK-like | 1 | 1 |  |