Domain combination pairs in Haloquadratum walsbyi C23

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

438 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	23	14
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	10	4
"Winged helix" DNA-binding domain	P-loop containing nucleoside triphosphate hydrolases	10	5
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	9	4
Zinc beta-ribbon	Cyclin-like	8	2
Cyclin-like	Cyclin-like	8	2
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	8	3
GroES-like	NAD(P)-binding Rossmann-fold domains	8	1
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	6	5
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	6	4
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	6	2
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	6	5
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	5	4
P-loop containing nucleoside triphosphate hydrolases	MOP-like	5	2
Ribbon-helix-helix	ACT-like	5	1
Nucleic acid-binding proteins	Nucleic acid-binding proteins	5	5
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	4
TrkA C-terminal domain-like	TrkA C-terminal domain-like	5	4
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	5	5
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	5	2
TATA-box binding protein-like	TATA-box binding protein-like	5	1
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	5	4
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	4	2
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	4	3
DNA methylase specificity domain	DNA methylase specificity domain	4	1
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	4
Hedgehog/intein (Hint) domain	Homing endonucleases	4	4
PreATP-grasp domain	Rudiment single hybrid motif	4	2
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	4	1
GroEL equatorial domain-like	GroEL-intermediate domain like	4	1
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	4	2
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	4	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	4	1
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	4	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	4	4
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	4	2
Hedgehog/intein (Hint) domain	Hedgehog/intein (Hint) domain	4	4
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	4	4
GroEL equatorial domain-like	GroEL apical domain-like	4	1
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	4	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	4	2
Folate-binding domain	Aminomethyltransferase beta-barrel domain	4	3
GroEL-intermediate domain like	GroEL apical domain-like	4	1
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	3	2
CheY-like	PYP-like sensor domain (PAS domain)	3	3
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	2
ADC-like	Cdc48 domain 2-like	3	1
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	3	1
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	3	1
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	3	2
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	3	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	3	1
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	2
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	3	2
Thiolase-like	Thiolase-like	3	1
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	3	1
Homing endonucleases	Homing endonucleases	3	3
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	3	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	3	2
CheY-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	3	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	3	2
CheY-like	Homodimeric domain of signal transducing histidine kinase	3	3
GAF domain-like	PYP-like sensor domain (PAS domain)	3	3
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	3	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	3	2
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	3	2
PurM N-terminal domain-like	PurM C-terminal domain-like	3	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	3	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	3	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	2
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	1
Hedgehog/intein (Hint) domain	P-loop containing nucleoside triphosphate hydrolases	2	2
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	2
Voltage-gated potassium channels	TrkA C-terminal domain-like	2	1
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	2	2
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	2	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	2	2
(Trans)glycosidases	Glycosyl hydrolase domain	2	2
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	2	1
ACT-like	ACT-like	2	2
vWA-like	Class I glutamine amidotransferase-like	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	2
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Hedgehog/intein (Hint) domain	2	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	2	2
CBS-domain pair	FAD-binding/transporter-associated domain-like	2	1
Translation proteins	ThrRS/AlaRS common domain	2	2
FAD/NAD(P)-binding domain	Folate-binding domain	2	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
HMA, heavy metal-associated domain	HAD-like	2	2
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	2	1
Sm-like ribonucleoproteins	Mechanosensitive channel protein MscS (YggB), C-terminal domain	2	2
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	2	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	2	1
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	2	2
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	2	1
Calcium ATPase, transduction domain A	HAD-like	2	2
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	2	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	2	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	2
Actin-like ATPase domain	Actin-like ATPase domain	2	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	2	2
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Thiamin diphosphate-binding fold (THDP-binding)	2	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	2	1
Thioredoxin-like	Six-hairpin glycosidases	2	2
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	2	1
Nucleic acid-binding proteins	Translation proteins SH3-like domain	2	2
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	2	2
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	1
FAD-linked reductases, C-terminal domain	Folate-binding domain	2	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	TK C-terminal domain-like	2	1
Translational machinery components	L30e-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	2
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	2
Periplasmic binding protein-like II	Periplasmic binding protein-like II	2	2
Glutamine synthetase/guanido kinase	GatB/YqeY motif	2	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	2	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	2	1
Ribosomal protein S5 domain 2-like	Hedgehog/intein (Hint) domain	2	2
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	2	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	2	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	2	1
Nucleic acid-binding proteins	DHH phosphoesterases	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	2	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	1
Phospholipase D/nuclease	Phospholipase D/nuclease	2	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	2	2
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	1	1
MurD-like peptide ligases, catalytic domain	Dihydropteroate synthetase-like	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	1	1
MFS general substrate transporter	MFS general substrate transporter	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
lambda repressor-like DNA-binding domains	CBS-domain pair	1	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	1	1
DNA polymerase beta, N-terminal domain-like	Sec63 N-terminal domain-like	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
PRTase-like	PRTase-like	1	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	1	1
NAD kinase/diacylglycerol kinase-like	Carbohydrate phosphatase	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
Six-hairpin glycosidases	Galactose mutarotase-like	1	1
PFL-like glycyl radical enzymes	PFL-like glycyl radical enzymes	1	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	1	1
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	1	1
Nucleotidyltransferase	PHP domain-like	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
Histone-fold	Histone-fold	1	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	1	1
Translation proteins	EF-G C-terminal domain-like	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease N-terminal domain-like	1	1
"Winged helix" DNA-binding domain	TrkA C-terminal domain-like	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	1	1
FAD-binding/transporter-associated domain-like	alpha-helical ferredoxin	1	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
beta and beta-prime subunits of DNA dependent RNA-polymerase	Hedgehog/intein (Hint) domain	1	1
HD-domain/PDEase-like	P-loop containing nucleoside triphosphate hydrolases	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	1	1
FYSH domain	EF-G C-terminal domain-like	1	1
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	Hedgehog/intein (Hint) domain	1	1
Sec63 N-terminal domain-like	PHP domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
PreATP-grasp domain	Single hybrid motif	1	1
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	1	1
DNA clamp	DNA clamp	1	1
NAD(P)-binding Rossmann-fold domains	Glutathione synthetase ATP-binding domain-like	1	1
PPK N-terminal domain-like	PHP14-like	1	1
FAD-linked oxidases, C-terminal domain	alpha-helical ferredoxin	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Periplasmic binding protein-like I	Periplasmic binding protein-like I	1	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
P-loop containing nucleoside triphosphate hydrolases	Homing endonucleases	1	1
Smc hinge domain	Tropomyosin	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
CBS-domain pair	Rubredoxin-like	1	1
TGS-like	Class II aaRS ABD-related	1	1
Ribonuclease H-like	DNA/RNA polymerases	1	1
Hedgehog/intein (Hint) domain	DNA/RNA polymerases	1	1
Rudiment single hybrid motif	Single hybrid motif	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
GAD domain-like	GatB/YqeY motif	1	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	1	1
Aldolase	AFP III-like domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
Hedgehog/intein (Hint) domain	post-AAA+ oligomerization domain-like	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	1	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
RuvA domain 2-like	BRCT domain	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
Six-hairpin glycosidases	Six-hairpin glycosidases	1	1
Pentapeptide repeat-like	Pentapeptide repeat-like	1	1
tRNA-intron endonuclease catalytic domain-like	tRNA-intron endonuclease catalytic domain-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Ribonuclease H-like	Homing endonucleases	1	1
beta and beta-prime subunits of DNA dependent RNA-polymerase	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Galactose mutarotase-like	Glycosyl hydrolase domain	1	1
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	1	1
Pectin lyase-like	Pectin lyase-like	1	1
PhoU-like	TrkA C-terminal domain-like	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Chaperone J-domain	2Fe-2S ferredoxin-like	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	1	1
"Winged helix" DNA-binding domain	Riboflavin kinase-like	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	1	1
"Helical backbone" metal receptor	"Helical backbone" metal receptor	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
PHP14-like	Phospholipase D/nuclease	1	1
Zinc-binding domain of translation initiation factor 2 beta	Nucleic acid-binding proteins	1	1
Aminoacid dehydrogenase-like, N-terminal domain	Isocitrate/Isopropylmalate dehydrogenase-like	1	1
Glutamine synthetase/guanido kinase	GAD domain-like	1	1
Iron-dependent repressor protein, dimerization domain	C-terminal domain of transcriptional repressors	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
"Winged helix" DNA-binding domain	TrmB C-terminal domain-like	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Hedgehog/intein (Hint) domain	Type II DNA topoisomerase	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
Translation proteins	Ribosomal protein S5 domain 2-like	1	1
Homing endonucleases	PFL-like glycyl radical enzymes	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	1	1
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	1	1
DNA/RNA polymerases	DNA/RNA polymerases	1	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	1	1
CbiG N-terminal domain-like	CobE/GbiG C-terminal domain-like	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
DNA/RNA polymerases	Homing endonucleases	1	1
NAD(P)-binding Rossmann-fold domains	DHH phosphoesterases	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	1	1
CBS-domain pair	CBS-domain pair	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
PIN domain-like	Prokaryotic type KH domain (KH-domain type II)	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
UROD/MetE-like	UROD/MetE-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
Cadherin-like	Starch-binding domain-like	1	1
Rhodanese/Cell cycle control phosphatase	Metallo-hydrolase/oxidoreductase	1	1
Staphylococcal nuclease	Lamin A/C globular tail domain	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	1	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
Actin-like ATPase domain	Protein kinase-like (PK-like)	1	1
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
Galactose mutarotase-like	(Trans)glycosidases	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Nucleotide-diphospho-sugar transferases	Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain	1	1
PhoU-like	PhoU-like	1	1
DnaJ/Hsp40 cysteine-rich domain	Pseudouridine synthase	1	1
MetI-like	MetI-like	1	1
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
"Winged helix" DNA-binding domain	Nucleotidyltransferase	1	1
Periplasmic binding protein-like II	GlnB-like	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Rad51 N-terminal domain-like	Ribonuclease H-like	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
PK beta-barrel domain-like	Phosphohistidine domain	1	1
Nucleotidylyl transferase	Ribosomal protein L25-like	1	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease catalytic domain-like	1	1
Class II aaRS and biotin synthetases	C-terminal domain of transcriptional repressors	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
"Winged helix" DNA-binding domain	CheY-like	1	1
Ribonuclease H-like	Hedgehog/intein (Hint) domain	1	1
NAD(P)-binding Rossmann-fold domains	Siroheme synthase middle domains-like	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	1	1
ParB/Sulfiredoxin	KorB DNA-binding domain-like	1	1
PIN domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Type II DNA topoisomerase	Type II DNA topoisomerase	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
Radical SAM enzymes	PsbU/PolX domain-like	1	1
Restriction endonuclease-like	RuvA domain 2-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
GIY-YIG endonuclease	C-terminal UvrC-binding domain of UvrB	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Nucleic acid-binding proteins	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Nucleic acid-binding proteins	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
NAD(P)-binding Rossmann-fold domains	Isocitrate/Isopropylmalate dehydrogenase-like	1	1
Thioredoxin-like	GST C-terminal domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	1	1
DNA polymerase beta, N-terminal domain-like	PHP domain-like	1	1
PK C-terminal domain-like	Phosphohistidine domain	1	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-linked oxidoreductase	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
lambda repressor-like DNA-binding domains	AraD/HMP-PK domain-like	1	1
Sec63 N-terminal domain-like	Nucleotidyltransferase	1	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	1	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	1	1
GatD N-terminal domain-like	Glutaminase/Asparaginase	1	1
Prokaryotic type KH domain (KH-domain type II)	Metallo-hydrolase/oxidoreductase	1	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
CheY-like	GAF domain-like	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	1	1
alpha/beta-Hydrolases	Rad51 N-terminal domain-like	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
GIY-YIG endonuclease	RuvA domain 2-like	1	1
AN1-like Zinc finger	Rhomboid-like	1	1
Hypothetical protein AF0491, middle domain	EF-G C-terminal domain-like	1	1
Calcium ATPase, transmembrane domain M	HAD-like	1	1
Nucleic acid-binding proteins	RuvA domain 2-like	1	1
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	1	1
PKD domain	PKD domain	1	1
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	1	1
ClpP/crotonase	ClpP/crotonase	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphoenolpyruvate/pyruvate domain	1	1
PPK N-terminal domain-like	Phospholipase D/nuclease	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
CBS-domain pair	ParB/Sulfiredoxin	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
Rad51 N-terminal domain-like	Ribosomal protein L32e	1	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	1	1
Chelatase	Thioredoxin-like	1	1
Initiation factor IF2/eIF5b, domain 3	Translation proteins	1	1
alpha/beta-Hydrolases	Galactose-binding domain-like	1	1
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	1	1
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	1	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	1	1
Nucleic acid-binding proteins	Homing endonucleases	1	1
Nqo5-like	HydB/Nqo4-like	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphohistidine domain	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	1	1
"Winged helix" DNA-binding domain	GAF domain-like	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NAD(P)-linked oxidoreductase	1	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Mechanosensitive channel protein MscS (YggB), C-terminal domain	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
PA domain	Zn-dependent exopeptidases	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	1	1
ACT-like	Formyltransferase	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	1	1
Serine metabolism enzymes domain	ACT-like	1	1
Formyltransferase	Cytidine deaminase-like	1	1
Carbamate kinase-like	ACT-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	1	1
PDZ domain-like	PDZ domain-like	1	1
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
Homeodomain-like	Ribonuclease H-like	1	1
Periplasmic binding protein-like II	ACT-like	1	1
Hedgehog/intein (Hint) domain	PFL-like glycyl radical enzymes	1	1
MurD-like peptide ligases, peptide-binding domain	Dihydropteroate synthetase-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
Bacterial fluorinating enzyme, N-terminal domain	Bacterial fluorinating enzyme, C-terminal domain	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1

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