Domain combination pairs in Perkinsus marinus ATCC 50983

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

• For a list of unique full length architectures for this genome click here (can be slow).

Graph of adjacent domain pairs.

• Remove domain pairs for which there is already a structure in the PDB
• Remove domain pairs which occur in any other genomes (slow)
• Remove domain pairs which are not adjacent to each other
• Remove different strains from the list of genomes compared to

Jump to [ Top of page · Add/remove domain pairs · Domain combination pairs ]

Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.

Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes ]

Domain combination pairs

1233 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
DNA/RNA polymerases	Ribonuclease H-like	127	38
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	121	53
RNA-binding domain, RBD	RNA-binding domain, RBD	97	23
Actin-like ATPase domain	Actin-like ATPase domain	59	12
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	41	14
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	40	15
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	40	11
HAD-like	Calcium ATPase, transmembrane domain M	38	15
Retrovirus zinc finger-like domains	DNA/RNA polymerases	38	15
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	38	5
Protein kinase-like (PK-like)	EF-hand	38	10
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	34	11
Calcium ATPase, transduction domain A	HAD-like	32	11
Retrovirus zinc finger-like domains	Ribonuclease H-like	31	13
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	30	12
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	30	1
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	30	9
CCCH zinc finger	CCCH zinc finger	28	9
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	28	12
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	28	12
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	27	10
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	27	13
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	25	2
TPR-like	TPR-like	24	12
Thioredoxin-like	GST C-terminal domain-like	23	2
Acid proteases	DNA/RNA polymerases	23	15
GroEL equatorial domain-like	GroEL apical domain-like	22	7
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	22	6
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	22	9
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	22	3
Cyclin-like	Cyclin-like	22	5
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	21	13
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	21	8
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	21	8
Retrovirus zinc finger-like domains	Acid proteases	21	9
Flavoproteins	Riboflavin synthase domain-like	21	8
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	21	16
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	20	5
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	20	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	20	5
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	18	6
WD40 repeat-like	WD40 repeat-like	18	8
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	18	4
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	18	6
Cytochrome b5-like heme/steroid binding domain	Cytochrome b5-like heme/steroid binding domain	18	18
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	18	3
GroEL-intermediate domain like	GroEL apical domain-like	17	5
Thiamin diphosphate-binding fold (THDP-binding)	4Fe-4S ferredoxins	17	9
Thiamin diphosphate-binding fold (THDP-binding)	Flavoproteins	17	9
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	17	3
GroEL equatorial domain-like	GroEL-intermediate domain like	16	4
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	16	9
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	4Fe-4S ferredoxins	16	8
Thiamin diphosphate-binding fold (THDP-binding)	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	15	7
Acid proteases	Ribonuclease H-like	15	10
Thiolase-like	Thiolase-like	15	5
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	15	5
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	15	5
RING/U-box	RING/U-box	15	9
Ankyrin repeat	Aminoacid dehydrogenase-like, N-terminal domain	14	2
TK C-terminal domain-like	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	14	6
Ankyrin repeat	NAD(P)-binding Rossmann-fold domains	14	2
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	14	5
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	14	4
TK C-terminal domain-like	4Fe-4S ferredoxins	14	6
Globin-like	Globin-like	14	12
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	14	3
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	14	7
GroES-like	NAD(P)-binding Rossmann-fold domains	14	5
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	13	8
Thioredoxin-like	Thioredoxin-like	13	8
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	13	4
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	13	2
Translation proteins	EF-G C-terminal domain-like	13	8
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	13	4
Cytochrome b5-like heme/steroid binding domain	Fumarate reductase respiratory complex transmembrane subunits	13	13
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	13	8
Thiamin diphosphate-binding fold (THDP-binding)	Riboflavin synthase domain-like	12	5
cAMP-binding domain-like	cAMP-binding domain-like	12	6
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	12	2
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	12	2
ARM repeat	ARM repeat	12	9
4Fe-4S ferredoxins	Flavoproteins	11	4
Nucleic acid-binding proteins	Nucleic acid-binding proteins	11	7
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	11	9
Fibronectin type III	Fibronectin type III	11	7
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	11	8
(Trans)glycosidases	Glycosyl hydrolase domain	11	6
TK C-terminal domain-like	Flavoproteins	11	4
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	11	4
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	11	4
PLP-dependent transferases	PLP-dependent transferases	11	6
EF-hand	EF-hand	11	8
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Flavoproteins	11	4
TK C-terminal domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	10	3
DNase I-like	DNA/RNA polymerases	10	8
4Fe-4S ferredoxins	Ferredoxin reductase-like, C-terminal NADP-linked domain	10	3
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Ferredoxin reductase-like, C-terminal NADP-linked domain	10	3
RNA-binding domain, RBD	WW domain	10	6
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	10	6
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	10	4
Thiamin diphosphate-binding fold (THDP-binding)	Ferredoxin reductase-like, C-terminal NADP-linked domain	10	3
TK C-terminal domain-like	Riboflavin synthase domain-like	10	3
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Riboflavin synthase domain-like	10	3
4Fe-4S ferredoxins	Riboflavin synthase domain-like	10	3
PK beta-barrel domain-like	PK C-terminal domain-like	10	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Cytochrome b5-like heme/steroid binding domain	10	10
FAD/NAD(P)-binding domain	Cytochrome b5-like heme/steroid binding domain	10	10
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	10	5
POZ domain	Skp1 dimerisation domain-like	10	2
Protein kinase-like (PK-like)	ARM repeat	10	9
Enolase N-terminal domain-like	Enolase C-terminal domain-like	9	1
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	9	5
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	9	4
EF-G C-terminal domain-like	EF-G C-terminal domain-like	9	7
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	9	3
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	9	5
Kelch motif	Kelch motif	9	8
Clc chloride channel	CBS-domain pair	8	5
RING/U-box	P-loop containing nucleoside triphosphate hydrolases	8	6
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	8	4
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	8	4
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	8	6
Nucleotidylyl transferase	Nucleotidylyl transferase	8	1
Zn-finger domain of Sec23/24	vWA-like	8	6
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	8	5
ABC transporter transmembrane region	ABC transporter transmembrane region	8	5
RING/U-box	CCCH zinc finger	8	5
beta-sandwich domain of Sec23/24	vWA-like	8	6
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	8	4
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	8	6
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	8	4
P-loop containing nucleoside triphosphate hydrolases	TGS-like	8	1
RING/U-box	SMAD/FHA domain	7	3
vWA-like	Helical domain of Sec23/24	7	5
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	7	1
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	7	3
Ankyrin repeat	Ankyrin repeat	7	6
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	7	2
Ribosomal protein S5 domain 2-like	EF-G C-terminal domain-like	7	5
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	7	5
DNA/RNA polymerases	DNA/RNA polymerases	7	5
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	7	2
Translation proteins	Initiation factor IF2/eIF5b, domain 3	7	3
FAD/NAD(P)-binding domain	Fumarate reductase respiratory complex transmembrane subunits	7	7
DHS-like NAD/FAD-binding domain	NAD(P)-binding Rossmann-fold domains	7	1
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	7	3
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Fumarate reductase respiratory complex transmembrane subunits	7	7
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	7	5
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	7	3
DHS-like NAD/FAD-binding domain	Formate/glycerate dehydrogenase catalytic domain-like	7	1
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	7	4
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	7	7
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	7	3
Voltage-gated potassium channels	cAMP-binding domain-like	7	5
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	7	6
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	6	4
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	6	4
GST C-terminal domain-like	Nucleic acid-binding proteins	6	3
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	6	4
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	6	4
Acetyl-CoA synthetase-like	ACP-like	6	6
Arginase/deacetylase	FYVE/PHD zinc finger	6	3
ARM repeat	WD40 repeat-like	6	6
E set domains	E set domains	6	6
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	6	4
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	6	5
Translation proteins	Ribosomal protein S5 domain 2-like	6	4
Voltage-gated potassium channels	EF-hand	6	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	6	2
Cullin homology domain	"Winged helix" DNA-binding domain	6	3
MFS general substrate transporter	MFS general substrate transporter	6	2
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	6	4
Cullin repeat-like	Cullin homology domain	6	3
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	6	2
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	6	2
FYVE/PHD zinc finger	FYVE/PHD zinc finger	6	4
Translation proteins SH3-like domain	Nucleic acid-binding proteins	6	3
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	6	2
WD40 repeat-like	P-loop containing nucleoside triphosphate hydrolases	6	5
P-loop containing nucleoside triphosphate hydrolases	NAD(P)-binding Rossmann-fold domains	6	6
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	6	6
DNase I-like	Ribonuclease H-like	6	6
Translational machinery components	L30e-like	6	3
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	5	4
Ribonuclease H-like	FYVE/PHD zinc finger	5	4
Thioredoxin-like	FAD-dependent thiol oxidase	5	2
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	5	5
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	5	4
ThrRS/AlaRS common domain	Class II aaRS ABD-related	5	3
CheY-like	Nucleotide cyclase	5	4
P-loop containing nucleoside triphosphate hydrolases	Aminoacid dehydrogenase-like, N-terminal domain	5	5
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	5	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	5	3
Ribonuclease H-like	Ribonuclease H-like	5	5
TGS-like	Class II aaRS ABD-related	5	3
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	5	4
Fibronectin type III	Anthrax protective antigen	5	5
WGR domain-like	Domain of poly(ADP-ribose) polymerase	5	4
Protein kinase-like (PK-like)	Ankyrin repeat	5	4
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5	3
Cysteine proteinases	Cysteine proteinases	5	5
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	5	4
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	5	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	5	3
TGS-like	Class II aaRS and biotin synthetases	5	3
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	4
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	5	1
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	5	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	5	2
beta-beta-alpha zinc fingers	Ribonuclease H-like	5	2
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	5	3
WGR domain-like	ADP-ribosylation	5	4
Zinc beta-ribbon	Cyclin-like	5	4
TGS-like	ThrRS/AlaRS common domain	5	3
P-loop containing nucleoside triphosphate hydrolases	EF-hand	5	4
Ubiquitin-like	UBA-like	5	1
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	5	5
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	4	1
Nucleotidylyl transferase	Ribosomal protein L25-like	4	2
Pseudouridine synthase	PUA domain-like	4	1
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	4	4
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	4	2
CAD & PB1 domains	RING/U-box	4	3
Starch-binding domain-like	UDP-Glycosyltransferase/glycogen phosphorylase	4	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	4	2
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	4	2
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	4	1
E set domains	Anthrax protective antigen	4	4
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	4	1
GroEL equatorial domain-like	GroEL equatorial domain-like	4	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	4	3
Cysteine proteinases	RING/U-box	4	4
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	4	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	4	2
ACT-like	ACT-like	4	4
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	4	2
NAD(P)-binding Rossmann-fold domains	FabD/lysophospholipase-like	4	4
Chaperone J-domain	Thioredoxin-like	4	3
Acid proteases	FYVE/PHD zinc finger	4	3
Sec7 domain	ARM repeat	4	4
WW domain	WW domain	4	4
Folate-binding domain	Aminomethyltransferase beta-barrel domain	4	4
Homeodomain-like	Homeodomain-like	4	4
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	4	2
HAD-like	BRCT domain	4	2
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	4	2
Class II aaRS ABD-related	C-terminal domain of ProRS	4	2
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	4	3
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	4	2
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	4	2
TATA-box binding protein-like	TATA-box binding protein-like	4	2
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	4	2
ARM repeat	Clathrin adaptor appendage domain	4	4
Ubiquitin-like	Ubiquitin-like	4	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	4	1
cAMP-binding domain-like	Ankyrin repeat	4	4
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	4	2
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	4	1
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	4	3
alpha/beta-Hydrolases	alpha/beta-Hydrolases	4	4
Fibronectin type III	E set domains	4	4
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	4	2
SNARE-like	SNARE fusion complex	4	1
RNA-binding domain, RBD	DNA/RNA polymerases	4	4
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	4	3
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	4	2
Cullin repeat-like	"Winged helix" DNA-binding domain	4	2
Arginase/deacetylase	Arginase/deacetylase	4	1
Starch-binding domain-like	HAD-like	4	3
Chaperone J-domain	Fibronectin type III	4	2
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	4	1
Doublecortin (DC)	Protein kinase-like (PK-like)	4	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	4	1
CCCH zinc finger	Acid proteases	4	3
PRTase-like	PRTase-like	4	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	4	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	4	4
Nucleic acid-binding proteins	eIF2alpha middle domain-like	4	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	3	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	3	2
P-loop containing nucleoside triphosphate hydrolases	E set domains	3	2
Voltage-gated potassium channels	Ankyrin repeat	3	3
alpha-helical ferredoxin	Nucleotide-binding domain	3	3
E set domains	Growth factor receptor domain	3	3
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	3	2
Carbamate kinase-like	PUA domain-like	3	2
tRNA-binding arm	Class II aaRS and biotin synthetases	3	1
WW domain	FKBP-like	3	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	3	2
Translation proteins	ThrRS/AlaRS common domain	3	2
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	3	3
CCCH zinc finger	Retrovirus zinc finger-like domains	3	2
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	3	1
NAD(P)-binding Rossmann-fold domains	S-adenosyl-L-methionine-dependent methyltransferases	3	2
Cysteine proteinases	DUSP-like	3	3
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	3	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	3	3
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	3	3
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	3	3
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	3	2
Nucleotide cyclase	Nucleotide cyclase	3	2
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	3	1
Ubiquitin-like	Zn-binding ribosomal proteins	3	1
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease H-like	3	3
Zinc beta-ribbon	Zinc beta-ribbon	3	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	3	3
HMA, heavy metal-associated domain	HAD-like	3	3
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	3	3
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	3	1
POZ domain	EF-hand	3	2
cAMP-binding domain-like	Protein kinase-like (PK-like)	3	3
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	3	3
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	3	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	3	3
Translation proteins	Translation proteins	3	2
PriA/YqbF domain	GINS helical bundle-like	3	2
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	3	2
EF-hand	WD40 repeat-like	3	3
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	3	2
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	3	1
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	3	3
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	3	3
CCCH zinc finger	RNA-binding domain, RBD	3	2
RNA-binding domain, RBD	PABC (PABP) domain	3	1
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	3	3
Thiamin phosphate synthase	Ribokinase-like	3	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	3	2
FMN-linked oxidoreductases	Nucleotide-binding domain	3	3
ThrRS/AlaRS common domain	Nucleotidylyl transferase	3	3
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	3	2
Pre-PUA domain	PUA domain-like	3	1
ADC-like	Cdc48 domain 2-like	3	2
Sec63 N-terminal domain-like	E set domains	3	2
SMAD/FHA domain	Tropomyosin	3	3
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	3	3
Retrovirus zinc finger-like domains	FYVE/PHD zinc finger	3	2
Calcium ATPase, transmembrane domain M	Nucleotide cyclase	3	2
Phospholipase C/P1 nuclease	Phospholipase C/P1 nuclease	3	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	3	1
Ankyrin repeat	RNA-binding domain, RBD	3	2
PurM N-terminal domain-like	PurM C-terminal domain-like	3	3
PH domain-like	RING/U-box	3	2
HAD-like	Nucleotide cyclase	3	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	3
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	3	3
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	3	2
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	3	2
Ribosomal protein L6	Ribosomal protein L6	3	1
WD40 repeat-like	TPR-like	3	3
TPR-like	Cyclophilin-like	3	2
Voltage-gated potassium channels	Voltage-gated potassium channels	3	3
ARM repeat	Subdomain of clathrin and coatomer appendage domain	3	3
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	3	1
TPR-like	Multidrug resistance efflux transporter EmrE	3	3
Growth factor receptor domain	Growth factor receptor domain	3	3
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	3	2
Ricin B-like lectins	Ricin B-like lectins	3	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	3	3
FMN-linked oxidoreductases	alpha-helical ferredoxin	3	3
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	3	3
Ubiquitin-like	Glucocorticoid receptor-like (DNA-binding domain)	3	2
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	3	2
POZ domain	Protein kinase-like (PK-like)	3	2
Metal cation-transporting ATPase, ATP-binding domain N	Nucleotide cyclase	3	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	3	3
Kelch motif	POZ domain	3	3
Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	3	2
Bet v1-like	Bet v1-like	3	2
Calcium ATPase, transduction domain A	Nucleotide cyclase	3	2
Ubiquitin-like	Cysteine proteinases	3	2
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	3	1
Trimeric LpxA-like enzymes	ARM repeat	3	2
Metallo-dependent phosphatases	EF-hand	3	3
Aldolase	Aldolase	3	2
Anthrax protective antigen	WD40 repeat-like	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	2
SNARE fusion complex	Protein kinase-like (PK-like)	2	1
Homocysteine S-methyltransferase	Methionine synthase domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	2	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	2	2
"Winged helix" DNA-binding domain	E set domains	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	2	2
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	2	2
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	2	2
ACP-like	Thiolase-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Cysteine-rich domain	MFS general substrate transporter	2	2
Heme oxygenase-like	Ribokinase-like	2	1
UDP-Glycosyltransferase/glycogen phosphorylase	SNARE-like	2	1
(Trans)glycosidases	(Trans)glycosidases	2	2
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	2	2
Putative DNA-binding domain	Class II aaRS and biotin synthetases	2	2
CCCH zinc finger	DNA/RNA polymerases	2	2
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	2	2
Mitochondrial carrier	HAD-like	2	1
beta-lactamase/transpeptidase-like	Ankyrin repeat	2	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	2	2
Formate/glycerate dehydrogenase catalytic domain-like	Formate/glycerate dehydrogenase catalytic domain-like	2	2
Protein kinase-like (PK-like)	PGBD-like	2	2
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	2	2
Polo-box domain	Polo-box domain	2	2
Protein kinase-like (PK-like)	WD40 repeat-like	2	2
Cysteine proteinases	UBA-like	2	2
Trypsin-like serine proteases	PDZ domain-like	2	1
Thioredoxin-like	PDZ domain-like	2	1
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	2	2
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	2	1
Oxidoreductase molybdopterin-binding domain	E set domains	2	1
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	2	1
NAD(P)-binding Rossmann-fold domains	SCP-like	2	1
SAP domain	RING/U-box	2	2
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	2	1
Homodimeric domain of signal transducing histidine kinase	CheY-like	2	2
DNA/RNA polymerases	FYVE/PHD zinc finger	2	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	2	2
P-loop containing nucleoside triphosphate hydrolases	Actin-like ATPase domain	2	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	2	2
Periplasmic binding protein-like II	ACT-like	2	2
beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	2	1
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	2	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	2
Cytidine deaminase-like	Ran binding protein zinc finger-like	2	1
CalX-like	CalX-like	2	2
Metallo-dependent hydrolases	Bacterial exopeptidase dimerisation domain	2	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	2	2
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	2	2
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	2	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	2	1
Putative DNA-binding domain	Protein kinase-like (PK-like)	2	2
BRCT domain	WGR domain-like	2	2
SNARE fusion complex	POZ domain	2	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	2	2
Dom34/Pelota N-terminal domain-like	L30e-like	2	2
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	2	2
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	2	2
AN1-like Zinc finger	AN1-like Zinc finger	2	2
EGF/Laminin	TSP-1 type 1 repeat	2	1
Thiolase-like	FabD/lysophospholipase-like	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	2
Class II aaRS and biotin synthetases	Class II aaRS and biotin synthetases	2	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	2
HIT/MYND zinc finger-like	Activator of Hsp90 ATPase, Aha1	2	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	2	2
Methylglyoxal synthase-like	Cytidine deaminase-like	2	1
RCC1/BLIP-II	RCC1/BLIP-II	2	2
vWA-like	SPOC domain-like	2	2
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	2	2
ACT-like	HAD-like	2	2
FKBP-like	Cyclophilin-like	2	1
Ankyrin repeat	Bromodomain	2	1
SNARE fusion complex	EF-hand	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	2
Protein kinase-like (PK-like)	Polo-box domain	2	2
Clathrin heavy-chain terminal domain	ARM repeat	2	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	2
SH3-domain	Ribonuclease H-like	2	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	2	1
EF-hand	TPR-like	2	1
WD40 repeat-like	NHL repeat	2	1
BRCT domain	ADP-ribosylation	2	2
DAK1/DegV-like	DhaL-like	2	1
Cysteine proteinases	Mannose-binding lectins	2	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Nucleotide cyclase	2	2
YbaK/ProRS associated domain	Class II aaRS and biotin synthetases	2	1
ADC synthase	Thiamin diphosphate-binding fold (THDP-binding)	2	2
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	2	2
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	2	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	2	2
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	2	2
DPP6 N-terminal domain-like	GYF domain	2	1
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	2	1
Cytochrome b5-like heme/steroid binding domain	E set domains	2	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	2	1
YbaK/ProRS associated domain	C-terminal domain of ProRS	2	1
PurS-like	Class I glutamine amidotransferase-like	2	2
Ankyrin repeat	Arginase/deacetylase	2	2
Eukaryotic type KH-domain (KH-domain type I)	SAP domain	2	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	2	1
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	2	2
Dihydropteroate synthetase-like	Methionine synthase domain	2	1
FKBP-like	TPR-like	2	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	2	2
PYP-like sensor domain (PAS domain)	CheY-like	2	2
PP2C-like	FKBP-like	2	2
Chromo domain-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
PurS-like	PurM N-terminal domain-like	2	2
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	2	2
SH3-domain	SH3-domain	2	1
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	1
DNA clamp	DNA clamp	2	1
RING/U-box	EF-hand	2	1
Lesion bypass DNA polymerase (Y-family), little finger domain	Ran binding protein zinc finger-like	2	1
L domain-like	L domain-like	2	2
P-loop containing nucleoside triphosphate hydrolases	SAP domain	2	2
Acyl-CoA N-acyltransferases (Nat)	P-loop containing nucleoside triphosphate hydrolases	2	2
PX domain	RNI-like	2	1
PK C-terminal domain-like	NTF2-like	2	2
ssDNA-binding transcriptional regulator domain	ssDNA-binding transcriptional regulator domain	2	2
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	2	2
Nucleoporin domain	TPR-like	2	1
Prokaryotic type I DNA topoisomerase	Acid proteases	2	2
RING/U-box	SH3-domain	2	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	2	2
t-snare proteins	SNARE fusion complex	2	1
AF0104/ALDC/Ptd012-like	AF0104/ALDC/Ptd012-like	2	1
SET domain	SH3-domain	2	1
Protein kinase-like (PK-like)	MFS general substrate transporter	2	2
Zinc beta-ribbon	P-loop containing nucleoside triphosphate hydrolases	2	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	2
YbaK/ProRS associated domain	Class II aaRS ABD-related	2	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
ARM repeat	PDZ domain-like	2	2
(Phosphotyrosine protein) phosphatases II	Actin depolymerizing proteins	2	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	2	1
alpha/beta-Hydrolases	Ypt/Rab-GAP domain of gyp1p	2	1
Putative DNA-binding domain	Cation efflux protein transmembrane domain-like	2	2
TRAF domain-like	TRAF domain-like	2	1
Origin of replication-binding domain, RBD-like	P-loop containing nucleoside triphosphate hydrolases	2	1
DNA/RNA polymerases	Ran binding protein zinc finger-like	2	1
PurM N-terminal domain-like	PurM N-terminal domain-like	2	2
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	2	1
Homodimeric domain of signal transducing histidine kinase	Nucleotide cyclase	2	2
EF-hand	Ankyrin repeat	2	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	2	2
Anthrax protective antigen	Anthrax protective antigen	2	2
CCCH zinc finger	beta-beta-alpha zinc fingers	2	1
PX domain	F-box domain	2	1
Thioredoxin-like	Mannose-binding lectins	2	1
ClpP/crotonase	ClpP/crotonase	2	2
Protein kinase-like (PK-like)	RNA-binding domain, RBD	2	2
MIT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Surp module (SWAP domain)	WW domain	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	2
Cation efflux protein transmembrane domain-like	Protein kinase-like (PK-like)	2	2
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	2	2
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	2	2
Protein kinase-like (PK-like)	Histone-fold	2	2
Single hybrid motif	CoA-dependent acyltransferases	2	1
PUG domain-like	Mannose-binding lectins	2	1
Eukaryotic type KH-domain (KH-domain type I)	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	2	2
PurM C-terminal domain-like	PurM C-terminal domain-like	2	2
Methionine synthase domain	Methionine synthase activation domain-like	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Nucleotide-binding domain	2	2
F-box domain	RNI-like	2	1
SMAD/FHA domain	SMAD/FHA domain	2	2
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	2	1
PurS-like	FGAM synthase PurL, linker domain	2	2
PP2C-like	HIT/MYND zinc finger-like	2	1
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	2	2
Concanavalin A-like lectins/glucanases	Galactose-binding domain-like	2	2
CCCH zinc finger	Ribonuclease H-like	2	2
Indigoidine synthase A-like	Ribokinase-like	2	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
RNA-binding domain, RBD	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
S-adenosyl-L-methionine-dependent methyltransferases	ARM repeat	2	2
FF domain	FF domain	2	2
FYSH domain	Hypothetical protein AF0491, middle domain	2	2
Acetyl-CoA synthetase-like	Thiolase-like	2	2
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	2	2
FAD/NAD(P)-binding domain	CRAL/TRIO N-terminal domain	2	2
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	2	2
GST C-terminal domain-like	Class II aaRS and biotin synthetases	2	1
SET domain	RING/U-box	2	1
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	2	1
RNA-binding domain, RBD	Ribonuclease H-like	2	2
Molybdenum cofactor biosynthesis proteins	SMc04008-like	2	2
Single hybrid motif	Single hybrid motif	2	1
Galactose-binding domain-like	Galactose-binding domain-like	2	2
EF-hand	CorA soluble domain-like	2	2
Ubiquitin-like	Cap-Gly domain	2	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	2
Ankyrin repeat	Hect, E3 ligase catalytic domain	2	1
Zinc beta-ribbon	Translation proteins	2	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	2	1
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	2	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	2	2
(Trans)glycosidases	Galactose-binding domain-like	2	2
Dom34/Pelota N-terminal domain-like	Translational machinery components	2	2
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	2	1
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	P-loop containing nucleoside triphosphate hydrolases	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	2
Zinc beta-ribbon	EF-G C-terminal domain-like	2	1
ARM repeat	Anthrax protective antigen	2	2
MoeA C-terminal domain-like	SMc04008-like	2	2
Tropomyosin	Tropomyosin	2	2
DNase I-like	P-loop containing nucleoside triphosphate hydrolases	2	2
Thioredoxin-like	Cysteine proteinases	2	1
Kelch motif	P-loop containing nucleoside triphosphate hydrolases	2	2
Metallo-dependent hydrolases	Zn-dependent exopeptidases	2	2
Carbamate kinase-like	ACT-like	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Metallo-dependent phosphatases	2	1
PurS-like	PurM C-terminal domain-like	2	2
Isochorismatase-like hydrolases	Glutamine synthetase/guanido kinase	2	1
Retrovirus zinc finger-like domains	RING/U-box	2	2
PUG domain-like	Cysteine proteinases	2	1
Kelch motif	S-adenosyl-L-methionine-dependent methyltransferases	2	2
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	2	2
Chorismate mutase II	Periplasmic binding protein-like II	2	2
CCCH zinc finger	P-loop containing nucleoside triphosphate hydrolases	2	2
CCCH zinc finger	Homeodomain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	2	1
EF-hand	beta-lactamase/transpeptidase-like	2	1
2Fe-2S ferredoxin-like	RNI-like	2	2
Voltage-gated potassium channels	E set domains	2	2
PAZ domain	Ribonuclease H-like	2	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	2	1
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	2	2
POZ domain	Galactose oxidase, central domain	2	2
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	2	2
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	2	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	2	2
Thioredoxin-like	PUG domain-like	2	1
lambda integrase-like, N-terminal domain	DNA breaking-rejoining enzymes	2	2
MoeA N-terminal region -like	SMc04008-like	2	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	2	2
Chromo domain-like	SAP domain	2	1
Bromodomain	Chromo domain-like	2	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	2	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	2	1
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	2	1
Mitochondrial carrier	BRCT domain	2	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	2	2
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	2	1
GST C-terminal domain-like	Nucleotidylyl transferase	2	2
Thioredoxin-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	2	1
RmlC-like cupins	PLP-dependent transferases	2	1
ISP domain	FAD/NAD(P)-binding domain	2	1
FAD/NAD(P)-binding domain	CRAL/TRIO domain	2	2
FYVE/PHD zinc finger	Bromodomain	2	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	Quinoprotein alcohol dehydrogenase-like	1	1
Nucleic acid-binding proteins	TPR-like	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	HAD-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	P-loop containing nucleoside triphosphate hydrolases	1	1
Class II aaRS and biotin synthetases	SufE/NifU	1	1
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	1	1
Creatinase/prolidase N-terminal domain	Creatinase/prolidase N-terminal domain	1	1
HSP20-like chaperones	HIT-like	1	1
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	1	1
EPT/RTPC-like	Aldolase	1	1
GAF domain-like	GAF domain-like	1	1
Bromodomain	SET domain	1	1
PUG domain-like	Ubiquitin-like	1	1
Protein kinase-like (PK-like)	Mitochondrial carrier	1	1
FAD/NAD(P)-binding domain	Folate-binding domain	1	1
Thiolase-like	alpha/beta-Hydrolases	1	1
Clavaminate synthase-like	DNase I-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
EF-hand	ARM repeat	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
HAD-like	HAD-like	1	1
Clavaminate synthase-like	Ribonuclease H-like	1	1
Cysteine-rich domain	ABC transporter transmembrane region	1	1
alpha/beta-Hydrolases	RING/U-box	1	1
PreATP-grasp domain	Rudiment single hybrid motif	1	1
Ribonuclease H-like	Tim10-like	1	1
HIT-like	WD40 repeat-like	1	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	1	1
FYVE/PHD zinc finger	Protein kinase-like (PK-like)	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Concanavalin A-like lectins/glucanases	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	TPR-like	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Glutathione synthetase ATP-binding domain-like	1	1
RNA-binding domain, RBD	Acid proteases	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
PFL-like glycyl radical enzymes	DPP6 N-terminal domain-like	1	1
Hedgehog/intein (Hint) domain	MIR domain	1	1
PLP-binding barrel	FMN-linked oxidoreductases	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	vWA-like	1	1
BAR/IMD domain-like	BAR/IMD domain-like	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
Zinc hairpin stack	RING/U-box	1	1
SNARE-like	Ribosomal protein S16	1	1
NAD(P)-binding Rossmann-fold domains	Actin-like ATPase domain	1	1
Flavoproteins	Radical SAM enzymes	1	1
Dehydroquinate synthase-like	NAD(P)-binding Rossmann-fold domains	1	1
Glucocorticoid receptor-like (DNA-binding domain)	SAP domain	1	1
PA domain	Alpha-L RNA-binding motif	1	1
beta-beta-alpha zinc fingers	WD40 repeat-like	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	1	1
Ankyrin repeat	ADP-ribosylation	1	1
Six-hairpin glycosidases	ARM repeat	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	P-loop containing nucleoside triphosphate hydrolases	1	1
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	1	1
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Ankyrin repeat	1	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Cysteine proteinases	NAD(P)-binding Rossmann-fold domains	1	1
Dimeric alpha+beta barrel	Protein kinase-like (PK-like)	1	1
Class I glutamine amidotransferase-like	PreATP-grasp domain	1	1
Glutathione synthetase ATP-binding domain-like	Nucleic acid-binding proteins	1	1
CCCH zinc finger	TPR-like	1	1
Ankyrin repeat	(Phosphotyrosine protein) phosphatases II	1	1
RNI-like	Ankyrin repeat	1	1
PLC-like phosphodiesterases	(Trans)glycosidases	1	1
PH domain-like	Glutaminase/Asparaginase	1	1
HSP20-like chaperones	Protein kinase-like (PK-like)	1	1
Thioredoxin-like	RING/U-box	1	1
RING/U-box	UBA-like	1	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	1	1
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
Complement control module/SCR domain	Complement control module/SCR domain	1	1
Dehydroquinate synthase-like	Cysteine proteinases	1	1
WD40 repeat-like	Putative isomerase YbhE	1	1
P-loop containing nucleoside triphosphate hydrolases	R3H domain	1	1
Metallo-hydrolase/oxidoreductase	EB1 dimerisation domain-like	1	1
MIT domain	Ubiquitin-like	1	1
DPP6 N-terminal domain-like	WD40 repeat-like	1	1
Casein kinase II beta subunit	Casein kinase II beta subunit	1	1
Arginase/deacetylase	SAICAR synthase-like	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
DNA/RNA polymerases	RmlC-like cupins	1	1
Myosin rod fragments	Clathrin adaptor appendage domain	1	1
ssDNA-binding transcriptional regulator domain	Multidrug efflux transporter AcrB transmembrane domain	1	1
ERO1-like	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	1	1
Galactose mutarotase-like	(Trans)glycosidases	1	1
PAP/OAS1 substrate-binding domain	Myosin rod fragments	1	1
HSP20-like chaperones	RNA-binding domain, RBD	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
EF-hand	Magnesium transport protein CorA, transmembrane region	1	1
HAD-like	Formin homology 2 domain (FH2 domain)	1	1
ISP domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
FF domain	Cysteine proteinases	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ALDH-like	1	1
Calcium ATPase, transmembrane domain M	Formin homology 2 domain (FH2 domain)	1	1
Multidrug resistance efflux transporter EmrE	Protein kinase-like (PK-like)	1	1
Fe-S cluster assembly (FSCA) domain-like	Protein kinase-like (PK-like)	1	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	1	1
CCCH zinc finger	FMN-linked oxidoreductases	1	1
TPR-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
SNARE fusion complex	SNARE fusion complex	1	1
RCC1/BLIP-II	Ypt/Rab-GAP domain of gyp1p	1	1
Cysteine proteinases	Chaperone J-domain	1	1
MFS general substrate transporter	Cysteine proteinases	1	1
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
ACP-like	NAD(P)-binding Rossmann-fold domains	1	1
Serpins	DNA/RNA polymerases	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
Aminoacid dehydrogenase-like, N-terminal domain	Actin-like ATPase domain	1	1
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	1	1
Mog1p/PsbP-like	Thioredoxin-like	1	1
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
t-snare proteins	alpha/beta-Hydrolases	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
ARM repeat	Chromo domain-like	1	1
Retrovirus zinc finger-like domains	Ankyrin repeat	1	1
Ribonuclease H-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
RNase III domain-like	RNase III domain-like	1	1
ERO1-like	Cytochrome b5-like heme/steroid binding domain	1	1
E set domains	HAD-like	1	1
Cysteine proteinases	Tricorn protease domain 2	1	1
NAD(P)-binding Rossmann-fold domains	cAMP-binding domain-like	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
beta and beta-prime subunits of DNA dependent RNA-polymerase	Cyclophilin-like	1	1
ADC synthase	alpha/beta-Hydrolases	1	1
Acyl-CoA N-acyltransferases (Nat)	S-adenosyl-L-methionine-dependent methyltransferases	1	1
SH3-domain	ABC transporter transmembrane region	1	1
dsRNA-binding domain-like	dsRNA-binding domain-like	1	1
Tubulin nucleotide-binding domain-like	Cyclin-like	1	1
Smc hinge domain	Tropomyosin	1	1
NagB/RpiA/CoA transferase-like	LmbE-like	1	1
PreATP-grasp domain	Single hybrid motif	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	1	1
Protein kinase-like (PK-like)	Cysteine proteinases	1	1
WD40 repeat-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Aldolase	1	1
EPT/RTPC-like	Aminoacid dehydrogenase-like, N-terminal domain	1	1
Cyclophilin-like	RING/U-box	1	1
HD-domain/PDEase-like	HD-domain/PDEase-like	1	1
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	1	1
PRTase-like	PreATP-grasp domain	1	1
FAH	HSP20-like chaperones	1	1
ACP-like	Ankyrin repeat	1	1
Mitochondrial carrier	Acyl-CoA N-acyltransferases (Nat)	1	1
MFS general substrate transporter	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
WW domain	Cytochrome b5-like heme/steroid binding domain	1	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
Cyclophilin-like	Histone-fold	1	1
PLP-dependent transferases	RNI-like	1	1
Pseudouridine synthase	TPR-like	1	1
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	1	1
Chaperone J-domain	HAD-like	1	1
EF-hand	GAF domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
UBC-like	UBA-like	1	1
Sialidases	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
beta-beta-alpha zinc fingers	RING/U-box	1	1
RNA-binding domain, RBD	Translation proteins	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
Protein kinase-like (PK-like)	Thioredoxin-like	1	1
EF-hand	Kelch motif	1	1
SPOC domain-like	SAP domain	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	CCCH zinc finger	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Cysteine proteinases	Ankyrin repeat	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
Nucleic acid-binding proteins	Kelch motif	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
ClpS-like	ARM repeat	1	1
Thioredoxin-like	ERP29 C domain-like	1	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	1	1
Dehydroquinate synthase-like	Aminoacid dehydrogenase-like, N-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	alpha/beta-Hydrolases	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
EPT/RTPC-like	Cysteine proteinases	1	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	1	1
YjbQ-like	YjbQ-like	1	1
FAD/NAD(P)-binding domain	Supernatant protein factor (SPF), C-terminal domain	1	1
PRTase-like	Glutathione synthetase ATP-binding domain-like	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
WWE domain	ADP-ribosylation	1	1
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Sec7 domain	Ypt/Rab-GAP domain of gyp1p	1	1
Chorismate mutase II	ACT-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Glycerol-3-phosphate (1)-acyltransferase	1	1
Chaperone J-domain	Homeodomain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HIT/MYND zinc finger-like	1	1
Calcium ATPase, transduction domain A	Calcium ATPase, transduction domain A	1	1
YWTD domain	YWTD domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	alpha/beta-Hydrolases	1	1
YrdC/RibB	RibA-like	1	1
Voltage-gated potassium channels	(Trans)glycosidases	1	1
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	1	1
TPR-like	ARM repeat	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Quinoprotein alcohol dehydrogenase-like	TPR-like	1	1
Thioredoxin-like	Tim10-like	1	1
ISP transmembrane anchor	ISP domain	1	1
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	1	1
Tex N-terminal region-like	Ribonuclease H-like	1	1
Nudix	Acid proteases	1	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	1	1
EF-hand	SAICAR synthase-like	1	1
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	1	1
Cyclophilin-like	Ubiquitin-like	1	1
DLC	Zinc hairpin stack	1	1
DNA/RNA polymerases	Cysteine proteinases	1	1
YbiA-like	RNA-binding domain, RBD	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
Acetyl-CoA synthetase-like	Ankyrin repeat	1	1
R3H domain	AN1-like Zinc finger	1	1
Proteasome activator	Proteasome activator	1	1
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	1	1
RNA-binding domain, RBD	Cytochrome b5-like heme/steroid binding domain	1	1
HSP20-like chaperones	TPR-like	1	1
F-box domain	TPR-like	1	1
alpha/beta-Hydrolases	Protein kinase-like (PK-like)	1	1
Actin-like ATPase domain	Ankyrin repeat	1	1
Cyclophilin-like	Cell cycle regulatory proteins	1	1
BolA-like	Carbohydrate phosphatase	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
UBA-like	Caspase-like	1	1
TPR-like	Putative DNA-binding domain	1	1
Nucleotidylyl transferase	HD-domain/PDEase-like	1	1
FYVE/PHD zinc finger	RING/U-box	1	1
P-loop containing nucleoside triphosphate hydrolases	LigT-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Calcium ATPase, transmembrane domain M	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
Translation initiation factor IF3, N-terminal domain	Protein kinase-like (PK-like)	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	1	1
Metallo-dependent phosphatases	P-loop containing nucleoside triphosphate hydrolases	1	1
Actin-like ATPase domain	Mitochondrial carrier	1	1
vWA-like	SAP domain	1	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	1	1
GAF domain-like	Ribokinase-like	1	1
Phosphofructokinase	Phosphofructokinase	1	1
P-loop containing nucleoside triphosphate hydrolases	RCC1/BLIP-II	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
DNase I-like	Cysteine proteinases	1	1
Cdc48 domain 2-like	RING/U-box	1	1
RING/U-box	HSP20-like chaperones	1	1
Seven-hairpin glycosidases	PA domain	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
NAD(P)-binding Rossmann-fold domains	MFS general substrate transporter	1	1
Globin-like	F-box domain	1	1
CYTH-like phosphatases	CYTH-like phosphatases	1	1
Adenine nucleotide alpha hydrolases-like	TPR-like	1	1
DPP6 N-terminal domain-like	Quinoprotein alcohol dehydrogenase-like	1	1
FAD-linked reductases, C-terminal domain	Folate-binding domain	1	1
POZ domain	WD40 repeat-like	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	1	1
Ubiquitin-like	AN1-like Zinc finger	1	1
Acyl-CoA N-acyltransferases (Nat)	RNA-binding domain, RBD	1	1
Anthrax protective antigen	P-loop containing nucleoside triphosphate hydrolases	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
CheY-like	TPR-like	1	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	TPR-like	1	1
Chromo domain-like	WW domain	1	1
DNA/RNA polymerases	Carbonic anhydrase	1	1
P-loop containing nucleoside triphosphate hydrolases	ACT-like	1	1
EF-hand	FAD-linked oxidoreductase	1	1
TPR-like	HCP-like	1	1
Ribonuclease H-like	RuvA domain 2-like	1	1
Kelch motif	Metallo-dependent phosphatases	1	1
WD40 repeat-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
SAICAR synthase-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
PUG domain-like	PR-1-like	1	1
FabD/lysophospholipase-like	GroES-like	1	1
Clavaminate synthase-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	1	1
Tricorn protease N-terminal domain	alpha/beta-Hydrolases	1	1
Actin-like ATPase domain	TPR-like	1	1
RuvA domain 2-like	RuvA domain 2-like	1	1
Phosphoenolpyruvate/pyruvate domain	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Mitochondrial carrier	Ribonuclease H-like	1	1
Chaperone J-domain	E set domains	1	1
Cysteine proteinases	Sec-C motif	1	1
EF-hand	Nucleotide cyclase	1	1
Calcium ATPase, transmembrane domain M	Calcium ATPase, transmembrane domain M	1	1
Eukaryotic type KH-domain (KH-domain type I)	Formin homology 2 domain (FH2 domain)	1	1
Tricorn protease domain 2	WD40 repeat-like	1	1
CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	1	1
Acetyl-CoA synthetase-like	CoA-dependent acyltransferases	1	1
WD40 repeat-like	Cyclophilin-like	1	1
DNA/RNA polymerases	lambda integrase-like, N-terminal domain	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Metallo-dependent phosphatases	RNA-binding domain, RBD	1	1
P-loop containing nucleoside triphosphate hydrolases	Cysteine proteinases	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
ARM repeat	ALDH-like	1	1
YbiA-like	SMAD/FHA domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Pseudouridine synthase	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
EF-hand	Anthrax protective antigen	1	1
ERO1-like	FAD/NAD(P)-binding domain	1	1
MFS general substrate transporter	EF-hand	1	1
DUSP-like	DUSP-like	1	1
Galactose oxidase, central domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	1	1
Clavaminate synthase-like	DNA/RNA polymerases	1	1
Nucleic acid-binding proteins	EF-hand	1	1
Cation efflux protein transmembrane domain-like	Ankyrin repeat	1	1
NAD(P)-linked oxidoreductase	YWTD domain	1	1
Cytochrome P450	Cytochrome P450	1	1
YbaK/ProRS associated domain	Ribonuclease H-like	1	1
Composite domain of metallo-dependent hydrolases	Bacterial exopeptidase dimerisation domain	1	1
P-loop containing nucleoside triphosphate hydrolases	UBC-like	1	1
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
Quinoprotein alcohol dehydrogenase-like	EF-hand	1	1
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	1	1
Multidrug resistance efflux transporter EmrE	WD40 repeat-like	1	1
FYVE/PHD zinc finger	SET domain	1	1
Ribosomal L27 protein-like	Acyl-CoA N-acyltransferases (Nat)	1	1
vWA-like	RING/U-box	1	1
Nudix	Prokaryotic type I DNA topoisomerase	1	1
P-loop containing nucleoside triphosphate hydrolases	Eukaryotic type KH-domain (KH-domain type I)	1	1
TPR-like	Protein kinase-like (PK-like)	1	1
Tim10-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
P-loop containing nucleoside triphosphate hydrolases	Calcium ATPase, transduction domain A	1	1
Phosphoenolpyruvate/pyruvate domain	NTF2-like	1	1
Protein kinase-like (PK-like)	Functional domain of the splicing factor Prp18	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Ribonuclease H-like	HRDC-like	1	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
RING/U-box	Homeodomain-like	1	1
NAD kinase/diacylglycerol kinase-like	Pseudouridine synthase	1	1
NAD(P)-binding Rossmann-fold domains	L domain-like	1	1
alpha/beta-Hydrolases	WD40 repeat-like	1	1
DLC	RING/U-box	1	1
FMN-linked oxidoreductases	PRTase-like	1	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	1	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	1	1
ClpP/crotonase	Protein kinase-like (PK-like)	1	1
PP2C-like	PP2C-like	1	1
Aminoacid dehydrogenase-like, N-terminal domain	FabD/lysophospholipase-like	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	1	1
Dehydroquinate synthase-like	EPT/RTPC-like	1	1
ATP12-like	Zinc beta-ribbon	1	1
Multidrug resistance efflux transporter EmrE	Seven-hairpin glycosidases	1	1
DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	1	1
Cystatin/monellin	S-adenosyl-L-methionine-dependent methyltransferases	1	1
BAR/IMD domain-like	SH3-domain	1	1
Ferritin-like	Ferritin-like	1	1
Thioredoxin-like	Ubiquitin-like	1	1
Chaperone J-domain	SAP domain	1	1
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	1	1
Phospholipase D/nuclease	Terpenoid cyclases/Protein prenyltransferases	1	1
Elongation factor TFIIS domain 2	Pseudouridine synthase	1	1
ENTH/VHS domain	GAT-like domain	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
4'-phosphopantetheinyl transferase	Glycerol-3-phosphate (1)-acyltransferase	1	1
Aldolase	NAD(P)-binding Rossmann-fold domains	1	1
Trypsin-like serine proteases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Glutathione synthetase ATP-binding domain-like	Translation proteins SH3-like domain	1	1
AN1-like Zinc finger	Ran binding protein zinc finger-like	1	1
Adhesin YadA, collagen-binding domain	Histone-fold	1	1
Retrovirus zinc finger-like domains	Protein kinase-like (PK-like)	1	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	WD40 repeat-like	1	1
CCCH zinc finger	WD40 repeat-like	1	1
TPR-like	Prefoldin	1	1
Multidrug resistance efflux transporter EmrE	RNA-binding domain, RBD	1	1
Chromo domain-like	Chromo domain-like	1	1
Metallo-hydrolase/oxidoreductase	HD-domain/PDEase-like	1	1
RNA-binding domain, RBD	SNARE-like	1	1
GroES-like	GroES-like	1	1
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	1	1
Zinc-binding domain of translation initiation factor 2 beta	ALDH-like	1	1
alpha/beta-Hydrolases	Galactose-binding domain-like	1	1
Clavaminate synthase-like	EF-hand	1	1
Polo-box domain	MFS general substrate transporter	1	1
P-loop containing nucleoside triphosphate hydrolases	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
VPS28 C-terminal domain-like	(Trans)glycosidases	1	1
ClpP/crotonase	HMG-box	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	1	1
YbiA-like	HAD-like	1	1
EPT/RTPC-like	P-loop containing nucleoside triphosphate hydrolases	1	1
"Winged helix" DNA-binding domain	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
TPR-like	Metallo-dependent phosphatases	1	1
beta-N-acetylhexosaminidase-like domain	beta-N-acetylhexosaminidase-like domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
Translation proteins SH3-like domain	Class II aaRS and biotin synthetases	1	1
Homodimeric domain of signal transducing histidine kinase	Homodimeric domain of signal transducing histidine kinase	1	1
Class I glutamine amidotransferase-like	ADC synthase	1	1
L domain-like	SMAD/FHA domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	1	1
HCP-like	HCP-like	1	1
Calcium-dependent phosphotriesterase	WD40 repeat-like	1	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
WD40 repeat-like	Acyl-CoA dehydrogenase NM domain-like	1	1
PsbU/PolX domain-like	Nucleotidyltransferase	1	1
Kelch motif	Cysteine proteinases	1	1
ACT-like	PLP-dependent transferases	1	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha/beta-Hydrolases	1	1
ADP-ribosylglycohydrolase	ADP-ribosylglycohydrolase	1	1
HIT/MYND zinc finger-like	SET domain	1	1
Cytidine deaminase-like	Dihydrofolate reductase-like	1	1
PFL-like glycyl radical enzymes	WD40 repeat-like	1	1
Class I glutamine amidotransferase-like	D-aminoacid aminotransferase-like PLP-dependent enzymes	1	1
Glucocorticoid receptor-like (DNA-binding domain)	RING/U-box	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
WW domain	FF domain	1	1
NAP-like	DNA/RNA polymerases	1	1
TPR-like	DNA repair protein MutS, domain III	1	1
Chaperone J-domain	P-loop containing nucleoside triphosphate hydrolases	1	1
TPR-like	"Winged helix" DNA-binding domain	1	1
Periplasmic binding protein-like II	PLP-dependent transferases	1	1
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	1	1
Kelch motif	E set domains	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
CCCH zinc finger	Quinoprotein alcohol dehydrogenase-like	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
L21p-like	Multidrug resistance efflux transporter EmrE	1	1
Ankyrin repeat	SAM/Pointed domain	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
ISP domain	Riboflavin synthase domain-like	1	1
RING/U-box	PX domain	1	1
CCCH zinc finger	SH3-domain	1	1
Endosomal sorting complex assembly domain	(Trans)glycosidases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	1	1
RING/U-box	CoA-transferase family III (CaiB/BaiF)	1	1
HSP20-like chaperones	Metallo-dependent phosphatases	1	1
Dehydroquinate synthase-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PH domain-like	BSD domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
Subtilisin-like	alpha/beta-Hydrolases	1	1
Thiamin diphosphate-binding fold (THDP-binding)	MFS general substrate transporter	1	1
UBC-like	UBC-like	1	1
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
Activating enzymes of the ubiquitin-like proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
2-methylcitrate dehydratase PrpD	2-methylcitrate dehydratase PrpD	1	1
P-loop containing nucleoside triphosphate hydrolases	FKBP-like	1	1
PX domain	PX domain	1	1
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
RNA-binding domain, RBD	RNI-like	1	1
Clavaminate synthase-like	Protein kinase-like (PK-like)	1	1
P-loop containing nucleoside triphosphate hydrolases	Metal cation-transporting ATPase, ATP-binding domain N	1	1
YjgF-like	YjgF-like	1	1
HAD-like	Protein kinase-like (PK-like)	1	1
P-loop containing nucleoside triphosphate hydrolases	TPR-like	1	1
Nop domain	Nudix	1	1
L domain-like	ARM repeat	1	1
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
SH3-domain	TPR-like	1	1
WD40 repeat-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
HCP-like	"Winged helix" DNA-binding domain	1	1
PP2C-like	SET domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Acyl-CoA dehydrogenase NM domain-like	1	1
Multidrug resistance efflux transporter EmrE	Putative DNA-binding domain	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	DPP6 N-terminal domain-like	1	1
PRP4-like	WD40 repeat-like	1	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	1	1
Translation initiation factor IF3, N-terminal domain	Clavaminate synthase-like	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
EF-hand	Pseudouridine synthase	1	1
UBA-like	PUG domain-like	1	1
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	1	1
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Dipeptidyl peptidase I (cathepsin C), exclusion domain	1	1
Pseudouridine synthase	Pseudouridine synthase	1	1
TPR-like	Six-hairpin glycosidases	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	1	1
SNARE-like	alpha/beta-Hydrolases	1	1
EF-hand	Globin-like	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	(Trans)glycosidases	1	1
RING/U-box	Nudix	1	1
Alpha-L RNA-binding motif	Pseudouridine synthase	1	1
PP2C-like	RNA-binding domain, RBD	1	1
RING/U-box	VC0467-like	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
Complement control module/SCR domain	ARM repeat	1	1
Cysteine-rich domain	P-loop containing nucleoside triphosphate hydrolases	1	1
ARM repeat	RNI-like	1	1
Rudiment single hybrid motif	Single hybrid motif	1	1
SAP domain	SAP domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
AraD/HMP-PK domain-like	HAD-like	1	1
Ribonuclease H-like	Cysteine proteinases	1	1
Surp module (SWAP domain)	Surp module (SWAP domain)	1	1
HAD-like	Glutathione synthetase ATP-binding domain-like	1	1
Single hybrid motif	ClpP/crotonase	1	1
Composite domain of metallo-dependent hydrolases	Zn-dependent exopeptidases	1	1
alpha/beta-Hydrolases	PRTase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	TPR-like	1	1
Multidrug resistance efflux transporter EmrE	Cation efflux protein transmembrane domain-like	1	1
Metallo-hydrolase/oxidoreductase	Calponin-homology domain, CH-domain	1	1
Nucleotidyltransferase	Myosin rod fragments	1	1
Rad51 N-terminal domain-like	Smc hinge domain	1	1
SAICAR synthase-like	Clavaminate synthase-like	1	1
EPT/RTPC-like	NAD(P)-binding Rossmann-fold domains	1	1
Histone-fold	Histone-fold	1	1
P-loop containing nucleoside triphosphate hydrolases	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
RNA-binding domain, RBD	HIT-like	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
SpoIIaa-like	cAMP-binding domain-like	1	1
UBC-like	SET domain	1	1
ADC synthase	D-aminoacid aminotransferase-like PLP-dependent enzymes	1	1
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	1	1
SMAD/FHA domain	RNA-binding domain, RBD	1	1
Phage fibre proteins	Phage fibre proteins	1	1
Metallo-dependent phosphatases	HIT-like	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
Expressed protein At2g23090/F21P24.15	NAD(P)-binding Rossmann-fold domains	1	1
Phosphoenolpyruvate/pyruvate domain	NAD(P)-binding Rossmann-fold domains	1	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	1	1
Cysteine proteinases	Aminoacid dehydrogenase-like, N-terminal domain	1	1
Cytidine deaminase-like	Cytidine deaminase-like	1	1
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	1	1
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	1	1
Phospholipase D/nuclease	Phospholipase D/nuclease	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Aldolase	Cysteine proteinases	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Prim-pol domain	MFS general substrate transporter	1	1
PX domain	ARM repeat	1	1
Fe-S cluster assembly (FSCA) domain-like	EF-hand	1	1
ARM repeat	Hect, E3 ligase catalytic domain	1	1
Galactose oxidase, central domain	Quinoprotein alcohol dehydrogenase-like	1	1
Seven-hairpin glycosidases	Tropomyosin	1	1
FabD/lysophospholipase-like	alpha/beta-Hydrolases	1	1
Nucleotide cyclase	TPR-like	1	1
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	1	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	1	1
L domain-like	Tropomyosin	1	1
TRAF domain-like	Cysteine proteinases	1	1
Sec63 N-terminal domain-like	HAD-like	1	1
Metallo-dependent phosphatases	Globin-like	1	1
Acyl-CoA dehydrogenase NM domain-like	"Winged helix" DNA-binding domain	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
TPR-like	Cation efflux protein transmembrane domain-like	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
Ankyrin repeat	PLP-dependent transferases	1	1
PUA domain-like	Ribosomal protein S5 domain 2-like	1	1
ARM repeat	RNA-binding domain, RBD	1	1
Phospholipase C/P1 nuclease	P-loop containing nucleoside triphosphate hydrolases	1	1
Rhomboid-like	Phosphoglycerate mutase-like	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
S-adenosyl-L-methionine-dependent methyltransferases	"Winged helix" DNA-binding domain	1	1
TolB, C-terminal domain	GYF domain	1	1
Aminoacid dehydrogenase-like, N-terminal domain	cAMP-binding domain-like	1	1
Ankyrin repeat	RING/U-box	1	1
Galactose oxidase, central domain	Kelch motif	1	1
ABC transporter transmembrane region	LigT-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Prokaryotic type KH domain (KH-domain type II)	1	1
Dehydroquinate synthase-like	Aldolase	1	1
L-aspartase-like	L-aspartase-like	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
vWA-like	Cysteine-rich domain	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
Cyclophilin-like	Cyclophilin-like	1	1
WD40 repeat-like	RING/U-box	1	1
Roadblock/LC7 domain	Zn-dependent exopeptidases	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PreATP-grasp domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
PLC-like phosphodiesterases	Glycosyl hydrolase domain	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Phospholipase D/nuclease	Ribosomal protein S6	1	1