All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
| Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
| L domain-like | P-loop containing nucleoside triphosphate hydrolases | 377 | 166 |  |
| L domain-like | L domain-like | 341 | 188 |  |
| L domain-like | Protein kinase-like (PK-like) | 293 | 78 |  |
| Toll/Interleukin receptor TIR domain | P-loop containing nucleoside triphosphate hydrolases | 288 | 127 |  |
| P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 239 | 115 |  |
| Protein kinase-like (PK-like) | Protein kinase-like (PK-like) | 232 | 66 |  |
| Toll/Interleukin receptor TIR domain | L domain-like | 186 | 110 |  |
| RNI-like | L domain-like | 154 | 90 |  |
| Cupredoxins | Cupredoxins | 107 | 19 |  |
| Actin-like ATPase domain | Actin-like ATPase domain | 103 | 16 |  |
| RNA-binding domain, RBD | RNA-binding domain, RBD | 100 | 27 |  |
| Barwin-like endoglucanases | PHL pollen allergen | 98 | 13 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | UDP-Glycosyltransferase/glycogen phosphorylase | 87 | 10 |  |
| GroES-like | NAD(P)-binding Rossmann-fold domains | 86 | 13 |  |
| RNI-like | Protein kinase-like (PK-like) | 83 | 40 |  |
| Cytochrome P450 | Cytochrome P450 | 81 | 14 |  |
| NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 74 | 26 |  |
| Terpenoid synthases | Terpenoid cyclases/Protein prenyltransferases | 72 | 12 |  |
| P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 72 | 48 |  |
| P-loop containing nucleoside triphosphate hydrolases | RNI-like | 72 | 48 |  |
| TPR-like | TPR-like | 70 | 23 |  |
| Thioredoxin-like | GST C-terminal domain-like | 70 | 8 |  |
| RING/U-box | RING/U-box | 60 | 21 |  |
| ABC transporter transmembrane region | P-loop containing nucleoside triphosphate hydrolases | 60 | 19 |  |
| (Trans)glycosidases | (Trans)glycosidases | 58 | 21 |  |
| alpha/beta-Hydrolases | alpha/beta-Hydrolases | 58 | 16 |  |
| Thiolase-like | Thiolase-like | 55 | 10 |  |
| Toll/Interleukin receptor TIR domain | "Winged helix" DNA-binding domain | 50 | 35 |  |
| F-box domain | Kelch motif | 50 | 9 |  |
| Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 49 | 8 |  |
| Plant invertase/pectin methylesterase inhibitor | Pectin lyase-like | 47 | 8 |  |
| Toll/Interleukin receptor TIR domain | Toll/Interleukin receptor TIR domain | 47 | 38 |  |
| RNI-like | RNI-like | 46 | 34 |  |
| "Winged helix" DNA-binding domain | L domain-like | 44 | 32 |  |
| DNA-binding domain | DNA-binding domain | 43 | 11 |  |
| (Trans)glycosidases | Glycosyl hydrolase domain | 41 | 9 |  |
| Heme-dependent peroxidases | Heme-dependent peroxidases | 41 | 4 |  |
| Clavaminate synthase-like | Clavaminate synthase-like | 41 | 7 |  |
| Concanavalin A-like lectins/glucanases | Protein kinase-like (PK-like) | 40 | 18 |  |
| "Winged helix" DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 40 | 6 |  |
| ARM repeat | ARM repeat | 39 | 17 |  |
| POZ domain | Skp1 dimerisation domain-like | 38 | 9 |  |
| Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 38 | 12 |  |
| Thioredoxin-like | Thioredoxin-like | 38 | 20 |  |
| Cullin homology domain | Cullin repeat-like | 37 | 10 |  |
| Toll/Interleukin receptor TIR domain | RNI-like | 36 | 30 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 36 | 12 |  |
| GroES-like | GroES-like | 35 | 11 |  |
| F-box domain | RNI-like | 35 | 11 |  |
| FAD/NAD(P)-binding domain | FAD-linked reductases, C-terminal domain | 34 | 10 |  |
| Cyclin-like | Cyclin-like | 34 | 14 |  |
| Pectin lyase-like | Pectin lyase-like | 34 | 10 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | 33 | 5 |  |
| Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 33 | 10 |  |
| ABC transporter transmembrane region | ABC transporter transmembrane region | 33 | 12 |  |
| Calcium ATPase, transmembrane domain M | HAD-like | 32 | 17 |  |
| Substrate-binding domain of HMG-CoA reductase | NAD-binding domain of HMG-CoA reductase | 31 | 11 |  |
| Calcium ATPase, transduction domain A | Calcium ATPase, transmembrane domain M | 30 | 20 |  |
| Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 30 | 7 |  |
| NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 29 | 11 |  |
| Cullin homology domain | "Winged helix" DNA-binding domain | 29 | 10 |  |
| RING/U-box | ARM repeat | 29 | 7 |  |
| MFS general substrate transporter | MFS general substrate transporter | 29 | 10 |  |
| (Trans)glycosidases | Beta-D-glucan exohydrolase, C-terminal domain | 29 | 5 |  |
| Terpenoid synthases | Terpenoid synthases | 28 | 9 |  |
| alpha-D-mannose-specific plant lectins | Protein kinase-like (PK-like) | 27 | 12 |  |
| Actin-like ATPase domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 27 | 8 |  |
| Acid proteases | Acid proteases | 26 | 7 |  |
| Concanavalin A-like lectins/glucanases | Concanavalin A-like lectins/glucanases | 26 | 15 |  |
| FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | 26 | 11 |  |
| Periplasmic binding protein-like I | Periplasmic binding protein-like II | 25 | 11 |  |
| Purple acid phosphatase, N-terminal domain | Metallo-dependent phosphatases | 25 | 8 |  |
| P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 25 | 16 |  |
| Terpenoid cyclases/Protein prenyltransferases | Terpenoid cyclases/Protein prenyltransferases | 24 | 9 |  |
| Homeodomain-like | Homeodomain-like | 24 | 11 |  |
| Metal cation-transporting ATPase, ATP-binding domain N | Calcium ATPase, transmembrane domain M | 23 | 14 |  |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | Lipoxigenase | 23 | 7 |  |
| beta-beta-alpha zinc fingers | beta-beta-alpha zinc fingers | 22 | 9 |  |
| Calcium ATPase, transduction domain A | HAD-like | 22 | 14 |  |
| Ypt/Rab-GAP domain of gyp1p | Ypt/Rab-GAP domain of gyp1p | 21 | 7 |  |
| Metal cation-transporting ATPase, ATP-binding domain N | HAD-like | 20 | 11 |  |
| NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 19 | 7 |  |
| Eukaryotic type KH-domain (KH-domain type I) | Eukaryotic type KH-domain (KH-domain type I) | 19 | 14 |  |
| Six-hairpin glycosidases | Six-hairpin glycosidases | 19 | 3 |  |
| Histone-fold | Histone-fold | 19 | 6 |  |
| GroEL equatorial domain-like | GroEL apical domain-like | 19 | 10 |  |
| HCP-like | HCP-like | 18 | 7 |  |
| Calcium ATPase, transduction domain A | Metal cation-transporting ATPase, ATP-binding domain N | 18 | 11 |  |
| Cullin repeat-like | "Winged helix" DNA-binding domain | 18 | 7 |  |
| TPR-like | HCP-like | 18 | 9 |  |
| CRAL/TRIO N-terminal domain | CRAL/TRIO domain | 17 | 8 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 17 | 13 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | C2 domain (Calcium/lipid-binding domain, CaLB) | 17 | 9 |  |
| FAD-binding/transporter-associated domain-like | FAD-linked oxidases, C-terminal domain | 17 | 4 |  |
| Plant lectins/antimicrobial peptides | Lysozyme-like | 17 | 7 |  |
| "Winged helix" DNA-binding domain | "Winged helix" DNA-binding domain | 16 | 10 |  |
| HMA, heavy metal-associated domain | HMA, heavy metal-associated domain | 16 | 10 |  |
| CCCH zinc finger | CCCH zinc finger | 16 | 12 |  |
| GroEL-intermediate domain like | GroEL equatorial domain-like | 16 | 10 |  |
| Riboflavin synthase domain-like | Ferredoxin reductase-like, C-terminal NADP-linked domain | 15 | 7 |  |
| Acetyl-CoA synthetase-like | Acetyl-CoA synthetase-like | 15 | 5 |  |
| E set domains | Galactose oxidase, central domain | 15 | 5 |  |
| ACT-like | ACT-like | 15 | 9 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Phospholipase D/nuclease | 15 | 10 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 15 | 6 |  |
| GroEL-intermediate domain like | GroEL apical domain-like | 15 | 9 |  |
| Bet v1-like | Bet v1-like | 15 | 5 |  |
| HAD-like | HAD-like | 15 | 6 |  |
| EF-hand | EF-hand | 14 | 6 |  |
| Galactose-binding domain-like | (Trans)glycosidases | 14 | 10 |  |
| Galactose-binding domain-like | Galactose-binding domain-like | 14 | 8 |  |
| RmlC-like cupins | RmlC-like cupins | 14 | 4 |  |
| NAD(P)-binding Rossmann-fold domains | LDH C-terminal domain-like | 14 | 4 |  |
| Trypsin-like serine proteases | PDZ domain-like | 14 | 3 |  |
| DNA-binding domain | DNA-binding pseudobarrel domain | 14 | 6 |  |
| "Winged helix" DNA-binding domain | RNI-like | 14 | 13 |  |
| Subtilisin-like | Subtilisin-like | 13 | 10 |  |
| Arabinanase/levansucrase/invertase | Concanavalin A-like lectins/glucanases | 13 | 3 |  |
| Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 13 | 6 |  |
| WRKY DNA-binding domain | WRKY DNA-binding domain | 13 | 4 |  |
| F-box domain | F-box domain | 12 | 10 |  |
| Actin depolymerizing proteins | Actin depolymerizing proteins | 12 | 8 |  |
| WD40 repeat-like | WD40 repeat-like | 12 | 6 |  |
| Kelch motif | Kelch motif | 12 | 6 |  |
| Adenine nucleotide alpha hydrolases-like | Protein kinase-like (PK-like) | 12 | 3 |  |
| Voltage-gated potassium channels | cAMP-binding domain-like | 12 | 7 |  |
| Cysteine proteinases | Cysteine proteinases | 12 | 4 |  |
| Protein kinase-like (PK-like) | EF-hand | 12 | 2 |  |
| Nucleotide-diphospho-sugar transferases | Nucleotide-diphospho-sugar transferases | 12 | 7 |  |
| PAZ domain | Ribonuclease H-like | 12 | 7 |  |
| Translation proteins | EF-G C-terminal domain-like | 12 | 12 |  |
| Cullin repeat-like | Cullin repeat-like | 12 | 8 |  |
| Barwin-like endoglucanases | Barwin-like endoglucanases | 11 | 8 |  |
| HSP40/DnaJ peptide-binding domain | HSP40/DnaJ peptide-binding domain | 11 | 8 |  |
| HMA, heavy metal-associated domain | Calcium ATPase, transmembrane domain M | 11 | 9 |  |
| ENTH/VHS domain | GAT-like domain | 11 | 4 |  |
| Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 11 | 6 |  |
| Aquaporin-like | Aquaporin-like | 11 | 3 |  |
| HMA, heavy metal-associated domain | Calcium ATPase, transduction domain A | 11 | 9 |  |
| Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 11 | 4 |  |
| EF-G C-terminal domain-like | Ribosomal protein S5 domain 2-like | 11 | 10 |  |
| S-adenosylmethionine synthetase | S-adenosylmethionine synthetase | 11 | 4 |  |
| Nucleic acid-binding proteins | Nucleic acid-binding proteins | 11 | 7 |  |
| Lysozyme-like | Lysozyme-like | 11 | 6 |  |
| alpha-D-mannose-specific plant lectins | alpha-D-mannose-specific plant lectins | 10 | 6 |  |
| PDZ domain-like | PDZ domain-like | 10 | 2 |  |
| Tubby C-terminal domain-like | Tubby C-terminal domain-like | 10 | 2 |  |
| Thioesterase/thiol ester dehydrase-isomerase | Thioesterase/thiol ester dehydrase-isomerase | 10 | 5 |  |
| P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 10 | 10 |  |
| UBC-like | UBC-like | 10 | 6 |  |
| PP2C-like | PP2C-like | 10 | 3 |  |
| F-box domain | Galactose oxidase, central domain | 10 | 6 |  |
| Double Clp-N motif | P-loop containing nucleoside triphosphate hydrolases | 10 | 7 |  |
| PLP-dependent transferases | PLP-dependent transferases | 10 | 5 |  |
| Phospholipase D/nuclease | Phospholipase D/nuclease | 10 | 8 |  |
| Periplasmic binding protein-like II | Periplasmic binding protein-like II | 10 | 8 |  |
| Ribonuclease H-like | Ribonuclease H-like | 10 | 5 |  |
| GAF domain-like | PYP-like sensor domain (PAS domain) | 10 | 7 |  |
| RNA-binding domain, RBD | Retrovirus zinc finger-like domains | 9 | 4 |  |
| P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 9 | 4 |  |
| dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 9 | 2 |  |
| Amine oxidase N-terminal region | Amine oxidase N-terminal region | 9 | 3 |  |
| (Trans)glycosidases | Chitinase insertion domain | 9 | 2 |  |
| Translation proteins | Ribosomal protein S5 domain 2-like | 9 | 9 |  |
| (Trans)glycosidases | Actin-crosslinking proteins | 9 | 4 |  |
| Ribonuclease H-like | DNA/RNA polymerases | 9 | 4 |  |
| FYVE/PHD zinc finger | FYVE/PHD zinc finger | 9 | 9 |  |
| Osmotin, thaumatin-like protein | Osmotin, thaumatin-like protein | 9 | 8 |  |
| dsRNA-binding domain-like | dsRNA-binding domain-like | 9 | 3 |  |
| Nucleotide-diphospho-sugar transferases | RING/U-box | 9 | 3 |  |
| RNase III domain-like | dsRNA-binding domain-like | 9 | 8 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | CheY-like | 9 | 5 |  |
| PHL pollen allergen | PHL pollen allergen | 9 | 8 |  |
| POZ domain | POZ domain | 9 | 8 |  |
| HSP20-like chaperones | HSP20-like chaperones | 9 | 4 |  |
| FYVE/PHD zinc finger | SET domain | 9 | 5 |  |
| Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 9 | 4 |  |
| Nucleotide-diphospho-sugar transferases | Trimeric LpxA-like enzymes | 9 | 4 |  |
| Activating enzymes of the ubiquitin-like proteins | Activating enzymes of the ubiquitin-like proteins | 9 | 3 |  |
| Osmotin, thaumatin-like protein | Protein kinase-like (PK-like) | 9 | 7 |  |
| HMA, heavy metal-associated domain | HAD-like | 9 | 7 |  |
| Homeodomain-like | Bet v1-like | 9 | 5 |  |
| Ribosomal protein S5 domain 2-like | HSP90 C-terminal domain | 9 | 7 |  |
| CheY-like | Homeodomain-like | 9 | 5 |  |
| Amine oxidase N-terminal region | Amine oxidase catalytic domain | 9 | 3 |  |
| GST C-terminal domain-like | GST C-terminal domain-like | 8 | 5 |  |
| Chaperone J-domain | HSP40/DnaJ peptide-binding domain | 8 | 5 |  |
| RNase III domain-like | RNase III domain-like | 8 | 8 |  |
| P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 8 | 4 |  |
| Periplasmic binding protein-like I | Periplasmic binding protein-like I | 8 | 6 |  |
| CheY-like | CheY-like | 8 | 6 |  |
| ARM repeat | P-loop containing nucleoside triphosphate hydrolases | 8 | 6 |  |
| Homodimeric domain of signal transducing histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 8 | 4 |  |
| NAC domain | NAC domain | 8 | 5 |  |
| Lipoxigenase | Lipoxigenase | 8 | 5 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | HSP90 C-terminal domain | 8 | 7 |  |
| Cysteine proteinases | Granulin repeat | 7 | 5 |  |
| Substrate-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 7 | 5 |  |
| EF-hand | Ferredoxin reductase-like, C-terminal NADP-linked domain | 7 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 7 | 7 |  |
| TPR-like | SET domain | 7 | 3 |  |
| RING/U-box | Protein kinase-like (PK-like) | 7 | 4 |  |
| Voltage-gated potassium channels | Ankyrin repeat | 7 | 4 |  |
| Chaperone J-domain | Chaperone J-domain | 7 | 4 |  |
| Outer arm dynein light chain 1 | L domain-like | 7 | 7 |  |
| UROD/MetE-like | UROD/MetE-like | 7 | 3 |  |
| RING/U-box | vWA-like | 7 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Protein kinase-like (PK-like) | 7 | 5 |  |
| Skp1 dimerisation domain-like | Skp1 dimerisation domain-like | 7 | 7 |  |
| LuxS/MPP-like metallohydrolase | LuxS/MPP-like metallohydrolase | 7 | 3 |  |
| Plant invertase/pectin methylesterase inhibitor | Plant invertase/pectin methylesterase inhibitor | 7 | 7 |  |
| Subtilisin-like | PA domain | 7 | 3 |  |
| cAMP-binding domain-like | Ankyrin repeat | 7 | 4 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | TK C-terminal domain-like | 7 | 2 |  |
| FMN-linked oxidoreductases | FMN-linked oxidoreductases | 7 | 3 |  |
| Ubiquitin-like | Ubiquitin-like | 7 | 3 |  |
| Homodimeric domain of signal transducing histidine kinase | CheY-like | 7 | 3 |  |
| PLP-binding barrel | Alanine racemase C-terminal domain-like | 7 | 2 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 7 | 5 |  |
| ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 7 | 4 |  |
| Zinc hairpin stack | RING/U-box | 6 | 4 |  |
| Galactose mutarotase-like | Glycosyl hydrolase domain | 6 | 3 |  |
| NTF2-like | RNA-binding domain, RBD | 6 | 3 |  |
| NAD(P)-linked oxidoreductase | NAD(P)-linked oxidoreductase | 6 | 1 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | AN1-like Zinc finger | 6 | 6 |  |
| ARID-like | HMG-box | 6 | 2 |  |
| PR-1-like | PR-1-like | 6 | 1 |  |
| Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 6 | 6 |  |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | DNA breaking-rejoining enzymes | 6 | 3 |  |
| CHY zinc finger-like | RING/U-box | 6 | 4 |  |
| Phosphoenolpyruvate/pyruvate domain | PK C-terminal domain-like | 6 | 3 |  |
| Clc chloride channel | CBS-domain pair | 6 | 4 |  |
| Galactose mutarotase-like | (Trans)glycosidases | 6 | 3 |  |
| Thiamin diphosphate-binding fold (THDP-binding) | DHS-like NAD/FAD-binding domain | 6 | 6 |  |
| Adenine nucleotide alpha hydrolases-like | Adenine nucleotide alpha hydrolases-like | 6 | 1 |  |
| EF-G C-terminal domain-like | EF-G C-terminal domain-like | 6 | 6 |  |
| Leukotriene A4 hydrolase N-terminal domain | Metalloproteases ("zincins"), catalytic domain | 6 | 3 |  |
| Periplasmic binding protein-like II | ACT-like | 6 | 4 |  |
| ARM repeat | Hect, E3 ligase catalytic domain | 6 | 5 |  |
| F-box domain | HCP-like | 6 | 3 |  |
| PK beta-barrel domain-like | Phosphoenolpyruvate/pyruvate domain | 6 | 3 |  |
| FAS1 domain | FAS1 domain | 6 | 5 |  |
| HCP-like | HIT/MYND zinc finger-like | 6 | 3 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | HAD-like | 6 | 3 |  |
| Calponin-homology domain, CH-domain | P-loop containing nucleoside triphosphate hydrolases | 6 | 3 |  |
| GAF domain-like | GAF domain-like | 6 | 5 |  |
| Peptidase/esterase 'gauge' domain | alpha/beta-Hydrolases | 6 | 4 |  |
| Translation proteins | Translation proteins | 6 | 6 |  |
| FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 5 | 2 |  |
| CHY zinc finger-like | Zinc hairpin stack | 5 | 3 |  |
| ADC-like | Cdc48 domain 2-like | 5 | 3 |  |
| PK beta-barrel domain-like | PK C-terminal domain-like | 5 | 2 |  |
| ADC-like | P-loop containing nucleoside triphosphate hydrolases | 5 | 4 |  |
| RCC1/BLIP-II | FYVE/PHD zinc finger | 5 | 3 |  |
| SNARE-like | SNARE fusion complex | 5 | 1 |  |
| Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 5 | 4 |  |
| Zinc beta-ribbon | Zinc beta-ribbon | 5 | 2 |  |
| DNA-binding pseudobarrel domain | CAD & PB1 domains | 5 | 2 |  |
| CBS-domain pair | CBS-domain pair | 5 | 4 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Adenine nucleotide alpha hydrolases-like | 5 | 2 |  |
| Acyl-CoA N-acyltransferases (Nat) | Acyl-CoA N-acyltransferases (Nat) | 5 | 2 |  |
| F-box domain | HIT/MYND zinc finger-like | 5 | 2 |  |
| Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 5 | 4 |  |
| HAD-like | BRCT domain | 5 | 3 |  |
| Enolase N-terminal domain-like | Enolase C-terminal domain-like | 5 | 3 |  |
| Translational machinery components | L30e-like | 5 | 5 |  |
| ALDH-like | ALDH-like | 5 | 2 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Translational machinery components | 5 | 5 |  |
| TRAF domain-like | POZ domain | 5 | 3 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 5 | 5 |  |
| Cystatin/monellin | Cystatin/monellin | 5 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Outer arm dynein light chain 1 | 5 | 5 |  |
| Thioredoxin-like | Cysteine-rich domain | 5 | 5 |  |
| Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 5 | 4 |  |
| Concanavalin A-like lectins/glucanases | P-domain of calnexin/calreticulin | 5 | 2 |  |
| Cdc48 domain 2-like | P-loop containing nucleoside triphosphate hydrolases | 5 | 5 |  |
| Translation proteins SH3-like domain | Nucleic acid-binding proteins | 5 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | FtsH protease domain-like | 5 | 3 |  |
| CoA-dependent acyltransferases | CoA-dependent acyltransferases | 5 | 3 |  |
| CCCH zinc finger | RNA-binding domain, RBD | 5 | 3 |  |
| EF-hand | Riboflavin synthase domain-like | 5 | 2 |  |
| (Phosphotyrosine protein) phosphatases II | C2 domain (Calcium/lipid-binding domain, CaLB) | 5 | 2 |  |
| FYVE/PHD zinc finger | P-loop containing nucleoside triphosphate hydrolases | 4 | 4 |  |
| Tubulin nucleotide-binding domain-like | Tubulin nucleotide-binding domain-like | 4 | 3 |  |
| vWA-like | C-terminal, gelsolin-like domain of Sec23/24 | 4 | 4 |  |
| FAD-binding/transporter-associated domain-like | FAD-binding/transporter-associated domain-like | 4 | 3 |  |
| Ricin B-like lectins | Ricin B-like lectins | 4 | 3 |  |
| UBA-like | Thioredoxin-like | 4 | 3 |  |
| Phosphoenolpyruvate/pyruvate domain | Phosphoenolpyruvate/pyruvate domain | 4 | 3 |  |
| DNase I-like | DNase I-like | 4 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | (Trans)glycosidases | 4 | 3 |  |
| Glucocorticoid receptor-like (DNA-binding domain) | Glucocorticoid receptor-like (DNA-binding domain) | 4 | 3 |  |
| SGNH hydrolase | SGNH hydrolase | 4 | 2 |  |
| Glycosyl hydrolase domain | Glycosyl hydrolase domain | 4 | 2 |  |
| beta-sandwich domain of Sec23/24 | Zn-finger domain of Sec23/24 | 4 | 4 |  |
| Nitrite/Sulfite reductase N-terminal domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 4 | 2 |  |
| PP2C-like | NAD(P)-linked oxidoreductase | 4 | 2 |  |
| UBA-like | Ubiquitin-like | 4 | 3 |  |
| FYVE/PHD zinc finger | RING/U-box | 4 | 4 |  |
| Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 4 | 3 |  |
| Nucleotidyltransferase | PAP/OAS1 substrate-binding domain | 4 | 3 |  |
| F-box domain | Tubby C-terminal domain-like | 4 | 1 |  |
| beta-sandwich domain of Sec23/24 | Helical domain of Sec23/24 | 4 | 4 |  |
| Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 4 | 4 |  |
| Sec7 domain | ARM repeat | 4 | 4 |  |
| YhbY-like | YhbY-like | 4 | 3 |  |
| Retrovirus zinc finger-like domains | Retrovirus zinc finger-like domains | 4 | 4 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Type II DNA topoisomerase | 4 | 3 |  |
| DNA-binding pseudobarrel domain | DNA-binding pseudobarrel domain | 4 | 4 |  |
| Zn-finger domain of Sec23/24 | Helical domain of Sec23/24 | 4 | 4 |  |
| Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 4 | 3 |  |
| PYP-like sensor domain (PAS domain) | PYP-like sensor domain (PAS domain) | 4 | 3 |  |
| Galactose mutarotase-like | Galactose mutarotase-like | 4 | 1 |  |
| Actin depolymerizing proteins | VHP, Villin headpiece domain | 4 | 3 |  |
| FMN-linked oxidoreductases | Alpha subunit of glutamate synthase, C-terminal domain | 4 | 3 |  |
| Acid proteases | Saposin | 4 | 3 |  |
| Homeodomain-like | FAD/NAD(P)-binding domain | 4 | 3 |  |
| Acyl-CoA dehydrogenase NM domain-like | Acyl-CoA dehydrogenase C-terminal domain-like | 4 | 4 |  |
| ARM repeat | WD40 repeat-like | 4 | 4 |  |
| beta-sandwich domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 4 | 4 |  |
| WD40 repeat-like | P-loop containing nucleoside triphosphate hydrolases | 4 | 3 |  |
| Histone-fold | RNI-like | 4 | 4 |  |
| FKBP-like | TPR-like | 4 | 2 |  |
| Tudor/PWWP/MBT | FYVE/PHD zinc finger | 4 | 4 |  |
| (Trans)glycosidases | Ricin B-like lectins | 4 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Cytochrome P450 | 4 | 4 |  |
| FKBP-like | FKBP-like | 4 | 2 |  |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 4 | 2 |  |
| NAC domain | Clavaminate synthase-like | 4 | 3 |  |
| Ribosomal protein S5 domain 2-like | Type II DNA topoisomerase | 4 | 3 |  |
| PLC-like phosphodiesterases | PLC-like phosphodiesterases | 4 | 4 |  |
| Zn-finger domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 4 | 4 |  |
| Mitochondrial carrier | Mitochondrial carrier | 4 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | TPR-like | 4 | 3 |  |
| NTF2-like | NTF2-like | 4 | 4 |  |
| Toll/Interleukin receptor TIR domain | Outer arm dynein light chain 1 | 4 | 4 |  |
| Dihydropteroate synthetase-like | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 4 | 4 |  |
| beta-sandwich domain of Sec23/24 | vWA-like | 4 | 4 |  |
| Zn-finger domain of Sec23/24 | vWA-like | 4 | 4 |  |
| PEP carboxykinase N-terminal domain | PEP carboxykinase-like | 4 | 2 |  |
| vWA-like | Helical domain of Sec23/24 | 4 | 4 |  |
| Helical domain of Sec23/24 | C-terminal, gelsolin-like domain of Sec23/24 | 4 | 4 |  |
| Staphylococcal nuclease | Tudor/PWWP/MBT | 4 | 4 |  |
| Cysteine-rich domain | Cysteine-rich domain | 4 | 2 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | FMN-linked oxidoreductases | 4 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | RING/U-box | 4 | 3 |  |
| Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | 4 | 4 |  |
| TPR-like | CAD & PB1 domains | 4 | 4 |  |
| Hect, E3 ligase catalytic domain | Hect, E3 ligase catalytic domain | 4 | 3 |  |
| Eukaryotic type KH-domain (KH-domain type I) | Chaperone J-domain | 4 | 3 |  |
| NagB/RpiA/CoA transferase-like | D-ribose-5-phosphate isomerase (RpiA), lid domain | 4 | 2 |  |
| UBA-like | UBA-like | 4 | 3 |  |
| CAD & PB1 domains | CAD & PB1 domains | 4 | 3 |  |
| LigB-like | LigB-like | 3 | 2 |  |
| Translation initiation factor 2 beta, aIF2beta, N-terminal domain | Zinc-binding domain of translation initiation factor 2 beta | 3 | 3 |  |
| Phosphoglycerate kinase | Phosphoglycerate kinase | 3 | 1 |  |
| Domain of poly(ADP-ribose) polymerase | ADP-ribosylation | 3 | 3 |  |
| Ankyrin repeat | Ankyrin repeat | 3 | 3 |  |
| AN1-like Zinc finger | AN1-like Zinc finger | 3 | 3 |  |
| vWA-like | vWA-like | 3 | 2 |  |
| TRAF domain-like | Cysteine proteinases | 3 | 1 |  |
| Protein kinase-like (PK-like) | "Winged helix" DNA-binding domain | 3 | 3 |  |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | Zinc beta-ribbon | 3 | 2 |  |
| Metallo-dependent phosphatases | Metallo-dependent phosphatases | 3 | 3 |  |
| Leukotriene A4 hydrolase N-terminal domain | ARM repeat | 3 | 1 |  |
| Homeodomain-like | FAD-linked reductases, C-terminal domain | 3 | 2 |  |
| Metalloproteases ("zincins"), catalytic domain | ARM repeat | 3 | 1 |  |
| RING/U-box | TRAF domain-like | 3 | 3 |  |
| Calponin-homology domain, CH-domain | EB1 dimerisation domain-like | 3 | 1 |  |
| alpha-helical ferredoxin | Nucleotide-binding domain | 3 | 2 |  |
| E set domains | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 |  |
| CAD & PB1 domains | Protein kinase-like (PK-like) | 3 | 1 |  |
| Folate-binding domain | Folate-binding domain | 3 | 3 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | Formin homology 2 domain (FH2 domain) | 3 | 1 |  |
| PA domain | Zn-dependent exopeptidases | 3 | 2 |  |
| Acetyl-CoA synthetase-like | SRF-like | 3 | 2 |  |
| Kelch motif | Galactose oxidase, central domain | 3 | 3 |  |
| BEACH domain | WD40 repeat-like | 3 | 2 |  |
| Molybdopterin synthase subunit MoaE | Molybdopterin synthase subunit MoaE | 3 | 2 |  |
| ClpP/crotonase | NAD(P)-binding Rossmann-fold domains | 3 | 2 |  |
| Rap30/74 interaction domains | "Winged helix" DNA-binding domain | 3 | 2 |  |
| Aminoacid dehydrogenase-like, N-terminal domain | Aminoacid dehydrogenase-like, N-terminal domain | 3 | 3 |  |
| Elongation factor TFIIS domain 2 | Zinc beta-ribbon | 3 | 2 |  |
| CCCH zinc finger | Eukaryotic type KH-domain (KH-domain type I) | 3 | 3 |  |
| Ankyrin repeat | P-loop containing nucleoside triphosphate hydrolases | 3 | 2 |  |
| Chromo domain-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| MCP/YpsA-like | MCP/YpsA-like | 3 | 2 |  |
| L-aspartase-like | L-aspartase-like | 3 | 3 |  |
| MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, peptide-binding domain | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | vWA-like | 3 | 1 |  |
| SET domain | SET domain | 3 | 3 |  |
| Folate-binding domain | Aminomethyltransferase beta-barrel domain | 3 | 2 |  |
| Saposin | Saposin | 3 | 3 |  |
| Six-hairpin glycosidases | vWA-like | 3 | 3 |  |
| DNA repair protein MutS, domain III | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 |  |
| HMG-box | HMG-box | 3 | 2 |  |
| RING/U-box | WD40 repeat-like | 3 | 3 |  |
| GST C-terminal domain-like | eEF-1beta-like | 3 | 1 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | Formate/glycerate dehydrogenase catalytic domain-like | 3 | 2 |  |
| PA domain | Transferrin receptor-like dimerisation domain | 3 | 2 |  |
| Voltage-gated potassium channels | Voltage-gated potassium channels | 3 | 3 |  |
| CRAL/TRIO N-terminal domain | Supernatant protein factor (SPF), C-terminal domain | 3 | 2 |  |
| Adenine nucleotide alpha hydrolases-like | RING/U-box | 3 | 2 |  |
| ARM repeat | C2 domain (Calcium/lipid-binding domain, CaLB) | 3 | 3 |  |
| (Phosphotyrosine protein) phosphatases II | Formin homology 2 domain (FH2 domain) | 3 | 1 |  |
| PAP/OAS1 substrate-binding domain | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 3 | 2 |  |
| Ribosomal protein L31e | Ribosomal protein L31e | 3 | 2 |  |
| FabD/lysophospholipase-like | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 3 | 2 |  |
| Mannose-binding lectins | Mannose-binding lectins | 3 | 2 |  |
| Ubiquitin-like | BAG domain | 3 | 2 |  |
| PEBP-like | PEBP-like | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | RNA-binding domain, RBD | 3 | 3 |  |
| BRCT domain | BRCT domain | 3 | 3 |  |
| DNA-binding domain | Tubulin C-terminal domain-like | 3 | 3 |  |
| Zn-dependent exopeptidases | Transferrin receptor-like dimerisation domain | 3 | 2 |  |
| Protein kinase-like (PK-like) | ARM repeat | 3 | 3 |  |
| FYVE/PHD zinc finger | Acyl-CoA N-acyltransferases (Nat) | 3 | 3 |  |
| HLH, helix-loop-helix DNA-binding domain | ACT-like | 3 | 1 |  |
| Nucleic acid-binding proteins | eIF2alpha middle domain-like | 3 | 3 |  |
| PriA/YqbF domain | GINS helical bundle-like | 3 | 2 |  |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | Elongation factor TFIIS domain 2 | 3 | 2 |  |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 3 | 3 |  |
| t-snare proteins | SNARE fusion complex | 3 | 2 |  |
| Purple acid phosphatase, N-terminal domain | Purple acid phosphatase, N-terminal domain | 3 | 3 |  |
| P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 3 | 2 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | L30e-like | 3 | 3 |  |
| RNA-binding domain, RBD | PABC (PABP) domain | 3 | 2 |  |
| Chromo domain-like | Chromo domain-like | 3 | 3 |  |
| UBC-like | L domain-like | 3 | 3 |  |
| SRF-like | SRF-like | 3 | 2 |  |
| TRAF domain-like | TRAF domain-like | 3 | 2 |  |
| PA domain | RING/U-box | 3 | 2 |  |
| Ribosomal protein L16p/L10e | NAC domain | 3 | 1 |  |
| alpha/beta-Hydrolases | (Trans)glycosidases | 3 | 3 |  |
| NAD-binding domain of HMG-CoA reductase | NAD-binding domain of HMG-CoA reductase | 3 | 3 |  |
| "Winged helix" DNA-binding domain | E2F-DP heterodimerization region | 3 | 2 |  |
| CRAL/TRIO domain | Supernatant protein factor (SPF), C-terminal domain | 3 | 2 |  |
| SNARE-like | Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 3 | 2 |  |
| HMA, heavy metal-associated domain | Protein kinase-like (PK-like) | 3 | 3 |  |
| Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 3 | 2 |  |
| Acyl-CoA dehydrogenase C-terminal domain-like | Acyl-CoA dehydrogenase C-terminal domain-like | 3 | 3 |  |
| Ribonuclease Rh-like | Ribonuclease Rh-like | 3 | 3 |  |
| Urease, gamma-subunit | Composite domain of metallo-dependent hydrolases | 2 | 2 |  |
| DnaJ/Hsp40 cysteine-rich domain | HSP40/DnaJ peptide-binding domain | 2 | 2 |  |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | Lipase/lipooxygenase domain (PLAT/LH2 domain) | 2 | 2 |  |
| BRCT domain | WGR domain-like | 2 | 2 |  |
| LysM domain | LysM domain | 2 | 2 |  |
| Concanavalin A-like lectins/glucanases | PH domain-like | 2 | 2 |  |
| DNA repair protein MutS, domain I | DNA repair protein MutS, domain II | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | ACT-like | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ribonuclease H-like | 2 | 2 |  |
| Histone-fold | Formate/glycerate dehydrogenase catalytic domain-like | 2 | 2 |  |
| Metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 2 | 2 |  |
| PH domain-like | HMG-box | 2 | 2 |  |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleotidylyl transferase | 2 | 2 |  |
| MIT domain | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 |  |
| PH domain-like | Cullin repeat-like | 2 | 2 |  |
| Rudiment single hybrid motif | Rudiment single hybrid motif | 2 | 2 |  |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Histone-fold | F-box domain | 2 | 2 |  |
| Cytochrome P450 | Protein kinase-like (PK-like) | 2 | 1 |  |
| ClpP/crotonase | ClpP/crotonase | 2 | 2 |  |
| PAZ domain | RNase III domain-like | 2 | 2 |  |
| Glutamine synthetase, N-terminal domain | Glutamine synthetase/guanido kinase | 2 | 1 |  |
| WWE domain | WWE domain | 2 | 2 |  |
| FYVE/PHD zinc finger | Chromo domain-like | 2 | 2 |  |
| Ribosomal protein L11, C-terminal domain | Ribosomal L11/L12e N-terminal domain | 2 | 2 |  |
| SAICAR synthase-like | SAICAR synthase-like | 2 | 2 |  |
| Plant lectins/antimicrobial peptides | Plant lectins/antimicrobial peptides | 2 | 2 |  |
| RNA-binding domain, RBD | HAD-like | 2 | 2 |  |
| E set domains | (Trans)glycosidases | 2 | 1 |  |
| FAD-binding/transporter-associated domain-like | Cytochrome P450 | 2 | 2 |  |
| Oxidoreductase molybdopterin-binding domain | Cytochrome b5-like heme/steroid binding domain | 2 | 2 |  |
| MurE/MurF N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 2 |  |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 2 | 2 |  |
| Actin depolymerizing proteins | C-terminal, gelsolin-like domain of Sec23/24 | 2 | 2 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | RNI-like | 2 | 1 |  |
| Ubiquitin-like | XPC-binding domain | 2 | 1 |  |
| HMA, heavy metal-associated domain | Metal cation-transporting ATPase, ATP-binding domain N | 2 | 2 |  |
| FYVE/PHD zinc finger | GroEL apical domain-like | 2 | 1 |  |
| Serine metabolism enzymes domain | ACT-like | 2 | 2 |  |
| Smc hinge domain | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Tex N-terminal region-like | Ribonuclease H-like | 2 | 2 |  |
| Calcium ATPase, transduction domain A | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| N-terminal domain of adenylylcyclase associated protein, CAP | C-terminal domain of adenylylcyclase associated protein | 2 | 1 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | ACT-like | 2 | 2 |  |
| RING/U-box | RNA-binding domain, RBD | 2 | 2 |  |
| Rhomboid-like | Ran binding protein zinc finger-like | 2 | 2 |  |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | CoA-dependent acyltransferases | 2 | 2 |  |
| GAF domain-like | CheY-like | 2 | 2 |  |
| EF-hand | Ubiquitin-like | 2 | 2 |  |
| Ubiquitin-like | Retrovirus zinc finger-like domains | 2 | 2 |  |
| Eukaryotic type KH-domain (KH-domain type I) | RNA-binding domain, RBD | 2 | 2 |  |
| UBA-like | XPC-binding domain | 2 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | dsRNA-binding domain-like | 2 | 2 |  |
| ENT-like | Tudor/PWWP/MBT | 2 | 2 |  |
| F1F0 ATP synthase subunit C | F1F0 ATP synthase subunit C | 2 | 1 |  |
| Voltage-gated potassium channels | EF-hand | 2 | 2 |  |
| DNA repair protein MutS, domain I | DNA repair protein MutS, domain III | 2 | 2 |  |
| Tudor/PWWP/MBT | SET domain | 2 | 2 |  |
| Aldolase | Aldolase | 2 | 2 |  |
| HLH, helix-loop-helix DNA-binding domain | HLH, helix-loop-helix DNA-binding domain | 2 | 2 |  |
| (Trans)glycosidases | Protein kinase-like (PK-like) | 2 | 2 |  |
| GroEL apical domain-like | SAICAR synthase-like | 2 | 1 |  |
| Eukaryotic RPB5 N-terminal domain | RPB5-like RNA polymerase subunit | 2 | 1 |  |
| DNA repair protein MutS, domain II | DNA repair protein MutS, domain III | 2 | 2 |  |
| "Winged helix" DNA-binding domain | RNA-binding domain, RBD | 2 | 2 |  |
| RCC1/BLIP-II | Protein kinase-like (PK-like) | 2 | 2 |  |
| Ran binding protein zinc finger-like | Ran binding protein zinc finger-like | 2 | 2 |  |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 2 | 1 |  |
| DNA repair protein MutS, domain II | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| vWA-like | SPOC domain-like | 2 | 2 |  |
| HAD-like | Glycerol-3-phosphate (1)-acyltransferase | 2 | 1 |  |
| WW domain | WW domain | 2 | 2 |  |
| PH domain-like | Oxysterol-binding protein-like | 2 | 2 |  |
| TATA-box binding protein-like | TATA-box binding protein-like | 2 | 1 |  |
| SPOC domain-like | C-terminal domain of Ku80 | 2 | 2 |  |
| Acid proteases | Protein kinase-like (PK-like) | 2 | 2 |  |
| Kelch motif | Metallo-dependent phosphatases | 2 | 2 |  |
| Class I glutamine amidotransferase-like | Class I glutamine amidotransferase-like | 2 | 1 |  |
| Nucleotidyltransferase | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 2 | 1 |  |
| R1 subunit of ribonucleotide reductase, N-terminal domain | PFL-like glycyl radical enzymes | 2 | 2 |  |
| GST C-terminal domain-like | Nucleotidylyl transferase | 2 | 2 |  |
| Ankyrin repeat | RNA-binding domain, RBD | 2 | 2 |  |
| ADP-ribosylation | Hemopexin-like domain | 2 | 2 |  |
| WWE domain | RING/U-box | 2 | 2 |  |
| PAZ domain | dsRNA-binding domain-like | 2 | 2 |  |
| PreATP-grasp domain | PreATP-grasp domain | 2 | 2 |  |
| Tudor/PWWP/MBT | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| DNA clamp | DNA clamp | 2 | 2 |  |
| RCC1/BLIP-II | RCC1/BLIP-II | 2 | 2 |  |
| Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 2 | 1 |  |
| Protein kinase-like (PK-like) | Skp1 dimerisation domain-like | 2 | 2 |  |
| GroEL equatorial domain-like | GroEL equatorial domain-like | 2 | 2 |  |
| WGR domain-like | ADP-ribosylation | 2 | 2 |  |
| Translational machinery components | Actin-crosslinking proteins | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Glycosyl hydrolase domain | 2 | 2 |  |
| Zinc beta-ribbon | Cyclin-like | 2 | 2 |  |
| Cytochrome P450 | Ribokinase-like | 2 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | Ubiquitin-like | 2 | 1 |  |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 6-phosphogluconate dehydrogenase C-terminal domain-like | 2 | 1 |  |
| Translation proteins | Initiation factor IF2/eIF5b, domain 3 | 2 | 2 |  |
| Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 2 | 2 |  |
| Ribokinase-like | Ribokinase-like | 2 | 2 |  |
| Flavoproteins | FMN-binding split barrel | 2 | 1 |  |
| Ribosomal protein L6 | Ribosomal protein L6 | 2 | 2 |  |
| TPR-like | RING/U-box | 2 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | Succinyl-CoA synthetase domains | 2 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 2 | 1 |  |
| Chromo domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 2 |  |
| (Trans)glycosidases | HSP40/DnaJ peptide-binding domain | 2 | 2 |  |
| FAD-linked reductases, C-terminal domain | FAD-linked reductases, C-terminal domain | 2 | 1 |  |
| E set domains | Ankyrin repeat | 2 | 1 |  |
| Class I glutamine amidotransferase-like | Adenine nucleotide alpha hydrolases-like | 2 | 2 |  |
| PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 2 |  |
| Sec63 N-terminal domain-like | E set domains | 2 | 2 |  |
| MFS general substrate transporter | 14-3-3 protein | 2 | 1 |  |
| ARM repeat | eIF4e-like | 2 | 1 |  |
| RING/U-box | Cysteine proteinases | 2 | 2 |  |
| CO dehydrogenase molybdoprotein N-domain-like | Molybdenum cofactor-binding domain | 2 | 2 |  |
| FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 2 | 1 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | Nucleotide-binding domain | 2 | 2 |  |
| Ferritin-like | Ferritin-like | 2 | 2 |  |
| L domain-like | EF-hand | 2 | 2 |  |
| alpha/beta-Hydrolases | Protein kinase-like (PK-like) | 2 | 2 |  |
| WD40 repeat-like | YVTN repeat-like/Quinoprotein amine dehydrogenase | 2 | 1 |  |
| Chaperone J-domain | DnaJ/Hsp40 cysteine-rich domain | 2 | 2 |  |
| alpha/beta-Hydrolases | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| POZ domain | TPR-like | 2 | 2 |  |
| Nitrite and sulphite reductase 4Fe-4S domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 2 | 1 |  |
| Trm112p-like | Trm112p-like | 2 | 2 |  |
| Cyclophilin-like | Cyclophilin-like | 2 | 2 |  |
| DNase I-like | EF-hand | 2 | 1 |  |
| Cytochrome c | Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor | 2 | 1 |  |
| Chalcone isomerase | Protein kinase-like (PK-like) | 2 | 2 |  |
| PUA domain-like | Nucleotidylyl transferase | 2 | 2 |  |
| SET domain | RuBisCo LSMT C-terminal, substrate-binding domain | 2 | 2 |  |
| Nitrite/Sulfite reductase N-terminal domain-like | Nitrite/Sulfite reductase N-terminal domain-like | 2 | 1 |  |
| Translation proteins | Cytochrome b5-like heme/steroid binding domain | 2 | 2 |  |
| Cullin homology domain | Cullin homology domain | 2 | 2 |  |
| RNA-binding domain, RBD | WW domain | 2 | 1 |  |
| Cryptochrome/photolyase, N-terminal domain | Cryptochrome/photolyase FAD-binding domain | 2 | 2 |  |
| Staphylococcal nuclease | Staphylococcal nuclease | 2 | 2 |  |
| Phosphofructokinase | Phosphofructokinase | 2 | 1 |  |
| POZ domain | Pentapeptide repeat-like | 2 | 1 |  |
| Ribosomal protein S10 | Tetrapyrrole methylase | 2 | 2 |  |
| GAF domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 2 | 2 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Protein kinase-like (PK-like) | 2 | 2 |  |
| Nucleotide-diphospho-sugar transferases | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| MurE/MurF N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 2 |  |
| PFL-like glycyl radical enzymes | PFL-like glycyl radical enzymes | 2 | 2 |  |
| RNA-binding domain, RBD | DNA-binding domain | 2 | 2 |  |
| SNARE fusion complex | SNARE fusion complex | 2 | 1 |  |
| Protein kinase-like (PK-like) | TPR-like | 2 | 2 |  |
| CBS-domain pair | CAD & PB1 domains | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | Serine metabolism enzymes domain | 2 | 2 |  |
| Thioredoxin-like | eEF1-gamma domain | 2 | 1 |  |
| BRCT domain | Domain of poly(ADP-ribose) polymerase | 2 | 2 |  |
| PAH2 domain | PAH2 domain | 2 | 1 |  |
| Protein kinase-like (PK-like) | POZ domain | 2 | 2 |  |
| Ribosomal protein S5 domain 2-like | Ribonuclease PH domain 2-like | 2 | 1 |  |
| FMN-linked oxidoreductases | Nucleotide-binding domain | 2 | 2 |  |
| Periplasmic binding protein-like II | GlnB-like | 2 | 1 |  |
| DNA-binding domain | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| RNA-binding domain, RBD | RNI-like | 2 | 2 |  |
| Nucleic acid-binding proteins | Ubiquitin-like | 2 | 2 |  |
| WD40 repeat-like | Quinoprotein alcohol dehydrogenase-like | 2 | 2 |  |
| FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 2 | 1 |  |
| 2Fe-2S ferredoxin-like | alpha-helical ferredoxin | 2 | 2 |  |
| Chaperone J-domain | 4Fe-4S ferredoxins | 2 | 1 |  |
| Chalcone isomerase | Chalcone isomerase | 2 | 2 |  |
| GST C-terminal domain-like | eEF1-gamma domain | 2 | 1 |  |
| Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 2 | 2 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | Serine metabolism enzymes domain | 2 | 2 |  |
| Ran binding protein zinc finger-like | RNA-binding domain, RBD | 2 | 2 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 2 | 2 |  |
| Protein kinase-like (PK-like) | KA1-like | 2 | 2 |  |
| Amine oxidase catalytic domain | Amine oxidase catalytic domain | 2 | 1 |  |
| POZ domain | Ankyrin repeat | 2 | 2 |  |
| E set domains | E set domains | 2 | 2 |  |
| FabD/lysophospholipase-like | FabD/lysophospholipase-like | 2 | 2 |  |
| Ankyrin repeat | Protein kinase-like (PK-like) | 2 | 1 |  |
| Beta-D-glucan exohydrolase, C-terminal domain | Beta-D-glucan exohydrolase, C-terminal domain | 2 | 2 |  |
| CCCH zinc finger | WD40 repeat-like | 2 | 1 |  |
| Fe-S cluster assembly (FSCA) domain-like | Fe-S cluster assembly (FSCA) domain-like | 2 | 2 |  |
| SAP domain | RNA-binding domain, RBD | 2 | 1 |  |
| Ankyrin repeat | RING/U-box | 2 | 2 |  |
| NAD(P)-binding Rossmann-fold domains | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| Protein kinase-like (PK-like) | GroES-like | 2 | 2 |  |
| (Trans)glycosidases | beta-Galactosidase/glucuronidase domain | 2 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 2 | 2 |  |
| Calcium ATPase, transduction domain A | Calcium ATPase, transduction domain A | 2 | 2 |  |
| HIT-like | HIT-like | 2 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | Quinoprotein alcohol dehydrogenase-like | 2 | 1 |  |
| WGR domain-like | Domain of poly(ADP-ribose) polymerase | 2 | 2 |  |
| Zn-dependent exopeptidases | Zn-dependent exopeptidases | 2 | 2 |  |
| BRCT domain | ADP-ribosylation | 2 | 2 |  |
| ARM repeat | PH domain-like | 2 | 2 |  |
| WWE domain | ADP-ribosylation | 2 | 1 |  |
| Aconitase iron-sulfur domain | LeuD/IlvD-like | 2 | 2 |  |
| UBC-like | Endosomal sorting complex assembly domain | 2 | 2 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | NAD(P)-linked oxidoreductase | 2 | 1 |  |
| Retrovirus zinc finger-like domains | Eukaryotic type KH-domain (KH-domain type I) | 2 | 2 |  |
| Coiled-coil domain of nucleotide exchange factor GrpE | Head domain of nucleotide exchange factor GrpE | 2 | 1 |  |
| ClpP/crotonase | 6-phosphogluconate dehydrogenase C-terminal domain-like | 2 | 1 |  |
| DNA repair protein MutS, domain I | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| FAD/NAD(P)-binding domain | Nucleotide-binding domain | 2 | 2 |  |
| Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 2 | 2 |  |
| AF0104/ALDC/Ptd012-like | AF0104/ALDC/Ptd012-like | 2 | 1 |  |
| WD40 repeat-like | Ribosomal protein S5 domain 2-like | 2 | 2 |  |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 2 |  |
| Rad51 N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 |  |
| CCCH zinc finger | ARM repeat | 2 | 1 |  |
| Class II aaRS and biotin synthetases | Class II aaRS and biotin synthetases | 2 | 2 |  |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 2 | 1 |  |
| RNA-binding domain, RBD | DPP6 N-terminal domain-like | 2 | 2 |  |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | L domain-like | 2 | 2 |  |
| Protein kinase-like (PK-like) | WD40 repeat-like | 2 | 2 |  |
| Nucleotidylyl transferase | Ribosomal protein L25-like | 2 | 2 |  |
| TPR-like | Chaperone J-domain | 2 | 2 |  |
| HD-domain/PDEase-like | Nucleotidyltransferase | 2 | 1 |  |
| Trypsin-like serine proteases | Trypsin-like serine proteases | 2 | 2 |  |
| DHS-like NAD/FAD-binding domain | DHS-like NAD/FAD-binding domain | 2 | 2 |  |
| GST C-terminal domain-like | Ribosomal protein L25-like | 2 | 2 |  |
| Phosphoenolpyruvate/pyruvate domain | FKBP-like | 2 | 2 |  |
| Transducin (alpha subunit), insertion domain | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
| P-loop containing nucleoside triphosphate hydrolases | Macro domain-like | 1 | 1 |  |
| PGBD-like | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
| Formate/glycerate dehydrogenase catalytic domain-like | Homeodomain-like | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Cysteine proteinases | 1 | 1 |  |
| SAM/Pointed domain | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| L domain-like | RING/U-box | 1 | 1 |  |
| 14-3-3 protein | 14-3-3 protein | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| Tudor/PWWP/MBT | DNA repair protein MutS, domain I | 1 | 1 |  |
| RNA-binding domain, RBD | NAC domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | RuvA domain 2-like | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Molybdenum cofactor-binding domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Ribokinase-like | 1 | 1 |  |
| Ribonuclease H-like | Actin-like ATPase domain | 1 | 1 |  |
| L domain-like | Cysteine proteinases | 1 | 1 |  |
| DNase I-like | Ribonuclease H-like | 1 | 1 |  |
| DNase I-like | "Winged helix" DNA-binding domain | 1 | 1 |  |
| RING/U-box | MFS general substrate transporter | 1 | 1 |  |
| Cytochrome b5-like heme/steroid binding domain | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 |  |
| L domain-like | Chaperone J-domain | 1 | 1 |  |
| Ribonuclease PH domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
| Heat shock protein 70kD (HSP70), peptide-binding domain | Subtilisin-like | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| ARID-like | FYVE/PHD zinc finger | 1 | 1 |  |
| Ribonuclease H-like | Acid proteases | 1 | 1 |  |
| Ribonuclease H-like | PP2C-like | 1 | 1 |  |
| "Winged helix" DNA-binding domain | E set domains | 1 | 1 |  |
| Cupredoxins | Phosphoglucomutase, C-terminal domain | 1 | 1 |  |
| (Trans)glycosidases | Actin-like ATPase domain | 1 | 1 |  |
| PA domain | PA domain | 1 | 1 |  |
| Chaperone J-domain | HSC20 (HSCB), C-terminal oligomerisation domain | 1 | 1 |  |
| UBC-like | Chaperone J-domain | 1 | 1 |  |
| Actin-like ATPase domain | FF domain | 1 | 1 |  |
| Globin-like | Acetyl-CoA synthetase-like | 1 | 1 |  |
| Calponin-homology domain, CH-domain | LysM domain | 1 | 1 |  |
| Sm-like ribonucleoproteins | Retrovirus zinc finger-like domains | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | 4Fe-4S ferredoxins | 1 | 1 |  |
| Tropomyosin | Tropomyosin | 1 | 1 |  |
| FAD-linked oxidases, C-terminal domain | PLP-dependent transferases | 1 | 1 |  |
| Leukotriene A4 hydrolase N-terminal domain | PHL pollen allergen | 1 | 1 |  |
| Ankyrin repeat | L domain-like | 1 | 1 |  |
| Class I glutamine amidotransferase-like | GMP synthetase C-terminal dimerisation domain | 1 | 1 |  |
| PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 1 | 1 |  |
| Calponin-homology domain, CH-domain | Multidrug resistance efflux transporter EmrE | 1 | 1 |  |
| alpha/beta-Hydrolases | Heme-dependent peroxidases | 1 | 1 |  |
| Toll/Interleukin receptor TIR domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| Oxysterol-binding protein-like | Oxysterol-binding protein-like | 1 | 1 |  |
| L30e-like | alpha/beta knot | 1 | 1 |  |
| DNA-binding domain | Cytochrome P450 | 1 | 1 |  |
| ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
| Families 57/38 glycoside transferase middle domain | Galactose mutarotase-like | 1 | 1 |  |
| beta-beta-alpha zinc fingers | SET domain | 1 | 1 |  |
| FF domain | FF domain | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Six-hairpin glycosidases | 1 | 1 |  |
| BEACH domain | ARM repeat | 1 | 1 |  |
| PRTase-like | Acid proteases | 1 | 1 |  |
| Cytidine deaminase-like | Dihydrofolate reductase-like | 1 | 1 |  |
| WD40 repeat-like | HSP90 C-terminal domain | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | PLP-dependent transferases | 1 | 1 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | Alpha subunit of glutamate synthase, C-terminal domain | 1 | 1 |  |
| Tudor/PWWP/MBT | DNA repair protein MutS, domain II | 1 | 1 |  |
| HAD-like | Riboflavin kinase-like | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | NTF2-like | 1 | 1 |  |
| L domain-like | Ribonuclease H-like | 1 | 1 |  |
| Flavoproteins | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | GIY-YIG endonuclease | 1 | 1 |  |
| Lipocalins | Lipocalins | 1 | 1 |  |
| RING/U-box | Histone-fold | 1 | 1 |  |
| ARM repeat | Tudor/PWWP/MBT | 1 | 1 |  |
| PH domain-like | ArfGap/RecO-like zinc finger | 1 | 1 |  |
| Ankyrin repeat | CCCH zinc finger | 1 | 1 |  |
| CO dehydrogenase ISP C-domain like | Molybdenum cofactor-binding domain | 1 | 1 |  |
| Putative DNA-binding domain | PheT/TilS domain | 1 | 1 |  |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | 1 |  |
| L domain-like | GroES-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | BEACH domain | 1 | 1 |  |
| RmlC-like cupins | Protein kinase-like (PK-like) | 1 | 1 |  |
| (Trans)glycosidases | Nucleotidylyl transferase | 1 | 1 |  |
| Retrovirus zinc finger-like domains | DNase I-like | 1 | 1 |  |
| NAD-binding domain of HMG-CoA reductase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | PP2C-like | 1 | 1 |  |
| Mitochondrial carrier | Protein kinase-like (PK-like) | 1 | 1 |  |
| all-alpha NTP pyrophosphatases | all-alpha NTP pyrophosphatases | 1 | 1 |  |
| Dimeric alpha+beta barrel | Dimeric alpha+beta barrel | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | HAND domain of the nucleosome remodeling ATPase ISWI | 1 | 1 |  |
| HCP-like | Thioredoxin-like | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | SMAD/FHA domain | 1 | 1 |  |
| YrdC/RibB | RibA-like | 1 | 1 |  |
| MFS general substrate transporter | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S7 | 1 | 1 |  |
| Chromo domain-like | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| Mitochondrial carrier | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Alpha subunit of glutamate synthase, C-terminal domain | 1 | 1 |  |
| alpha/beta-Hydrolases | D-ribose-5-phosphate isomerase (RpiA), lid domain | 1 | 1 |  |
| Nucleic acid-binding proteins | Retrovirus zinc finger-like domains | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Cyclin-like | 1 | 1 |  |
| Osmotin, thaumatin-like protein | (Trans)glycosidases | 1 | 1 |  |
| DNA-binding domain | PHL pollen allergen | 1 | 1 |  |
| FYVE/PHD zinc finger | PUA domain-like | 1 | 1 |  |
| AN1-like Zinc finger | Cytochrome P450 | 1 | 1 |  |
| ARM repeat | Clavaminate synthase-like | 1 | 1 |  |
| Alpha subunit of glutamate synthase, C-terminal domain | alpha-helical ferredoxin | 1 | 1 |  |
| Protein kinase-like (PK-like) | DNA-binding domain | 1 | 1 |  |
| Thioredoxin-like | Histone-fold | 1 | 1 |  |
| PH domain-like | Bet v1-like | 1 | 1 |  |
| RNA-binding domain, RBD | Ubiquitin-like | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Ribonuclease H-like | 1 | 1 |  |
| Indolic compounds 2,3-dioxygenase-like | Indolic compounds 2,3-dioxygenase-like | 1 | 1 |  |
| RNA-binding domain, RBD | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Starch-binding domain-like | Galactose-binding domain-like | 1 | 1 |  |
| Phosphoenolpyruvate/pyruvate domain | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 |  |
| Mitochondrial carrier | Concanavalin A-like lectins/glucanases | 1 | 1 |  |
| TAZ domain | RING/U-box | 1 | 1 |  |
| Cysteine proteinases | UBA-like | 1 | 1 |  |
| PYP-like sensor domain (PAS domain) | Protein kinase-like (PK-like) | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
| GroES-like | Galactose oxidase, central domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | PLP-dependent transferases | 1 | 1 |  |
| dsRNA-binding domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| SET domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Nucleotidyltransferase | Seven-hairpin glycosidases | 1 | 1 |  |
| PreATP-grasp domain | Rudiment single hybrid motif | 1 | 1 |  |
| ARM repeat | Clathrin adaptor appendage domain | 1 | 1 |  |
| CorA soluble domain-like | Magnesium transport protein CorA, transmembrane region | 1 | 1 |  |
| UBA-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | CO dehydrogenase flavoprotein C-terminal domain-like | 1 | 1 |  |
| PP2C-like | PHL pollen allergen | 1 | 1 |  |
| Subtilisin-like | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 |  |
| HD-domain/PDEase-like | HD-domain/PDEase-like | 1 | 1 |  |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 1 | 1 |  |
| DPP6 N-terminal domain-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Dom34/Pelota N-terminal domain-like | Translational machinery components | 1 | 1 |  |
| POZ domain | TAZ domain | 1 | 1 |  |
| Six-hairpin glycosidases | (Trans)glycosidases | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | Molybdenum cofactor-binding domain | 1 | 1 |  |
| RNase III domain-like | Ribosomal protein S10 | 1 | 1 |  |
| Heme-dependent peroxidases | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| NSFL1 (p97 ATPase) cofactor p47, SEP domain | Ubiquitin-like | 1 | 1 |  |
| DNA-binding pseudobarrel domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| Hairpin loop containing domain-like | WRKY DNA-binding domain | 1 | 1 |  |
| alpha/beta-Hydrolases | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | 1 |  |
| Aquaporin-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| RNI-like | Trypsin-like serine proteases | 1 | 1 |  |
| Undecaprenyl diphosphate synthase | Undecaprenyl diphosphate synthase | 1 | 1 |  |
| Cupredoxins | Phosphoglucomutase, first 3 domains | 1 | 1 |  |
| ThrRS/AlaRS common domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
| Ribokinase-like | Thiamin phosphate synthase | 1 | 1 |  |
| PLP-binding barrel | At5g01610-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | HydA/Nqo6-like | 1 | 1 |  |
| TPR-like | Thioredoxin-like | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Nop domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Bromodomain | 1 | 1 |  |
| Tex N-terminal region-like | Nucleic acid-binding proteins | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Phosphohistidine domain | 1 | 1 |  |
| At5g01610-like | At5g01610-like | 1 | 1 |  |
| EF-hand | Mitochondrial carrier | 1 | 1 |  |
| RNI-like | NAD-binding domain of HMG-CoA reductase | 1 | 1 |  |
| Thiamin pyrophosphokinase, catalytic domain | Thiamin pyrophosphokinase, substrate-binding domain | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Cupredoxins | 1 | 1 |  |
| PH domain-like | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Rhomboid-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | (Trans)glycosidases | 1 | 1 |  |
| Nucleic acid-binding proteins | RBP11-like subunits of RNA polymerase | 1 | 1 |  |
| GroEL apical domain-like | Galactose mutarotase-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | PAZ domain | 1 | 1 |  |
| Ligand-binding domain in the NO signalling and Golgi transport | Ligand-binding domain in the NO signalling and Golgi transport | 1 | 1 |  |
| Class II aaRS and biotin synthetases | Anticodon-binding domain of PheRS | 1 | 1 |  |
| Cytochrome P450 | Kelch motif | 1 | 1 |  |
| Chromo domain-like | ARM repeat | 1 | 1 |  |
| vWA-like | Cysteine-rich domain | 1 | 1 |  |
| Domain of the SRP/SRP receptor G-proteins | Domain of the SRP/SRP receptor G-proteins | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | AN1-like Zinc finger | 1 | 1 |  |
| ARM repeat | Phospholipase D/nuclease | 1 | 1 |  |
| Tricorn protease N-terminal domain | Tricorn protease N-terminal domain | 1 | 1 |  |
| PP2C-like | Nucleic acid-binding proteins | 1 | 1 |  |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 1 | 1 |  |
| DNA-binding domain | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| Urease, gamma-subunit | Urease, beta-subunit | 1 | 1 |  |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| RNI-like | Ribonuclease H-like | 1 | 1 |  |
| RNI-like | 14-3-3 protein | 1 | 1 |  |
| FMN-linked oxidoreductases | alpha-helical ferredoxin | 1 | 1 |  |
| Chromo domain-like | Ankyrin repeat | 1 | 1 |  |
| Ribosomal protein L19 (L19e) | Ribosomal protein L19 (L19e) | 1 | 1 |  |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Hypothetical protein YjiA, C-terminal domain | 1 | 1 |  |
| PIN domain-like | Nucleic acid-binding proteins | 1 | 1 |  |
| SAP domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | DNA/RNA polymerases | 1 | 1 |  |
| alpha/beta-Hydrolases | Cytochrome P450 | 1 | 1 |  |
| F-box domain | Tricorn protease N-terminal domain | 1 | 1 |  |
| Cysteine proteinases | Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 1 | 1 |  |
| ARM repeat | "Winged helix" DNA-binding domain | 1 | 1 |  |
| DNA breaking-rejoining enzymes | Trypsin-like serine proteases | 1 | 1 |  |
| Cyclophilin-like | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Arginase/deacetylase | Arginase/deacetylase | 1 | 1 |  |
| Cytochrome P450 | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| PH domain-like | BEACH domain | 1 | 1 |  |
| Bet v1-like | PYP-like sensor domain (PAS domain) | 1 | 1 |  |
| Barwin-like endoglucanases | TPR-like | 1 | 1 |  |
| Ribosomal protein L7/12, oligomerisation (N-terminal) domain | ClpS-like | 1 | 1 |  |
| Actin depolymerizing proteins | Actin-like ATPase domain | 1 | 1 |  |
| RNA polymerase subunits | RING/U-box | 1 | 1 |  |
| CO dehydrogenase ISP C-domain like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 |  |
| Multidrug efflux transporter AcrB transmembrane domain | Multidrug efflux transporter AcrB transmembrane domain | 1 | 1 |  |
| Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 1 | 1 |  |
| UBC-like | Mago nashi protein | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | Skp1 dimerisation domain-like | 1 | 1 |  |
| Cysteine proteinases | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| PAP/OAS1 substrate-binding domain | PAP/OAS1 substrate-binding domain | 1 | 1 |  |
| SufE/NifU | SufE/NifU | 1 | 1 |  |
| RuvA domain 2-like | RuvA domain 2-like | 1 | 1 |  |
| Chalcone isomerase | ATP-dependent DNA ligase DNA-binding domain | 1 | 1 |  |
| ENTH/VHS domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| CO dehydrogenase ISP C-domain like | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | beta-sandwich domain of Sec23/24 | 1 | 1 |  |
| Nudix | Ribonuclease H-like | 1 | 1 |  |
| Bacterial hemolysins | RING/U-box | 1 | 1 |  |
| Cysteine proteinases | Protein kinase-like (PK-like) | 1 | 1 |  |
| WD40 repeat-like | Barwin-like endoglucanases | 1 | 1 |  |
| PUG domain-like | Ubiquitin-like | 1 | 1 |  |
| Phosphoenolpyruvate/pyruvate domain | RING/U-box | 1 | 1 |  |
| TPR-like | Metallo-dependent phosphatases | 1 | 1 |  |
| FKBP-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 1 | 1 |  |
| FAD/NAD(P)-binding domain | RING/U-box | 1 | 1 |  |
| Carbamoyl phosphate synthetase, large subunit connection domain | Methylglyoxal synthase-like | 1 | 1 |  |
| ISY1 domain-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| NAC domain | NAD-binding domain of HMG-CoA reductase | 1 | 1 |  |
| Molybdenum cofactor biosynthesis proteins | MoeA C-terminal domain-like | 1 | 1 |  |
| RNA-binding domain, RBD | Heme-dependent peroxidases | 1 | 1 |  |
| PH domain-like | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| HAD-like | L-aspartase-like | 1 | 1 |  |
| F-box domain | L domain-like | 1 | 1 |  |
| HAD-like | NTF2-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| PDZ domain-like | Rubredoxin-like | 1 | 1 |  |
| Ribonuclease H-like | Nucleic acid-binding proteins | 1 | 1 |  |
| Ankyrin repeat | RCC1/BLIP-II | 1 | 1 |  |
| (Trans)glycosidases | POZ domain | 1 | 1 |  |
| Thioredoxin-like | Six-hairpin glycosidases | 1 | 1 |  |
| Acyl-CoA binding protein | Ankyrin repeat | 1 | 1 |  |
| Substrate-binding domain of HMG-CoA reductase | Toll/Interleukin receptor TIR domain | 1 | 1 |  |
| NagB/RpiA/CoA transferase-like | NagB/RpiA/CoA transferase-like | 1 | 1 |  |
| Probable bacterial effector-binding domain | Probable bacterial effector-binding domain | 1 | 1 |  |
| PYP-like sensor domain (PAS domain) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
| ABC transporter transmembrane region | Protein kinase-like (PK-like) | 1 | 1 |  |
| Cullin repeat-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| Tubulin nucleotide-binding domain-like | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 1 | 1 |  |
| Acetyl-CoA synthetase-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | RNase III domain-like | 1 | 1 |  |
| Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Methylglyoxal synthase-like | 1 | 1 |  |
| L30e-like | L30e-like | 1 | 1 |  |
| RING/U-box | BRCT domain | 1 | 1 |  |
| ThrRS/AlaRS common domain | Class II aaRS ABD-related | 1 | 1 |  |
| Translational machinery components | Translational machinery components | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | Putative isomerase YbhE | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Glutamyl tRNA-reductase dimerization domain | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Citrate synthase | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | WD40 repeat-like | 1 | 1 |  |
| Ribosomal protein L22 | Ribosomal protein L22 | 1 | 1 |  |
| RNI-like | Ankyrin repeat | 1 | 1 |  |
| TPR-like | CRAL/TRIO domain | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| TGS-like | Class II aaRS and biotin synthetases | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | Thioredoxin-like | 1 | 1 |  |
| Acyl-CoA dehydrogenase NM domain-like | Acyl-CoA dehydrogenase NM domain-like | 1 | 1 |  |
| Cu,Zn superoxide dismutase-like | Cu,Zn superoxide dismutase-like | 1 | 1 |  |
| F-box domain | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | Translational machinery components | 1 | 1 |  |
| Photosystem I subunits PsaA/PsaB | Photosystem I subunits PsaA/PsaB | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| ClpP/crotonase | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | 1 |  |
| FYVE/PHD zinc finger | Ribonuclease H-like | 1 | 1 |  |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | Epsilon subunit of mitochondrial F1F0-ATP synthase | 1 | 1 |  |
| Sigma2 domain of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 1 | 1 |  |
| Protein prenylyltransferase | Thioesterase/thiol ester dehydrase-isomerase | 1 | 1 |  |
| Chaperone J-domain | CSL zinc finger | 1 | 1 |  |
| Cullin repeat-like | ARM repeat | 1 | 1 |  |
| CAD & PB1 domains | UBA-like | 1 | 1 |  |
| WW domain | FF domain | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | MFS general substrate transporter | 1 | 1 |  |
| Pectin lyase-like | FAD-binding/transporter-associated domain-like | 1 | 1 |  |
| Aldolase | Aminoacid dehydrogenase-like, N-terminal domain | 1 | 1 |  |
| POZ domain | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| ISP transmembrane anchor | ISP domain | 1 | 1 |  |
| Lipoxigenase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| FAS1 domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Creatinase/prolidase N-terminal domain | Creatinase/prolidase N-terminal domain | 1 | 1 |  |
| ARM repeat | alpha/beta-Hydrolases | 1 | 1 |  |
| Periplasmic binding protein-like I | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| beta-Galactosidase/glucuronidase domain | Galactose mutarotase-like | 1 | 1 |  |
| ARM repeat | Subdomain of clathrin and coatomer appendage domain | 1 | 1 |  |
| RuvA domain 2-like | Nucleic acid-binding proteins | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Class I glutamine amidotransferase-like | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Mannose-binding lectins | 1 | 1 |  |
| BAR/IMD domain-like | Cullin homology domain | 1 | 1 |  |
| SAP domain | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 |  |
| Thiolase-like | Plant invertase/pectin methylesterase inhibitor | 1 | 1 |  |
| UBA-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Ribulose-phoshate binding barrel | Ribulose-phoshate binding barrel | 1 | 1 |  |
| Amidase signature (AS) enzymes | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Clavaminate synthase-like | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Trimeric LpxA-like enzymes | GHMP Kinase, C-terminal domain | 1 | 1 |  |
| F-box domain | NHL repeat | 1 | 1 |  |
| (Trans)glycosidases | PUA domain-like | 1 | 1 |  |
| ARM repeat | TPR-like | 1 | 1 |  |
| RING/U-box | Homeodomain-like | 1 | 1 |  |
| Glycoside hydrolase/deacetylase | Families 57/38 glycoside transferase middle domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| 4Fe-4S ferredoxins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| HMA, heavy metal-associated domain | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| ARM repeat | UBA-like | 1 | 1 |  |
| HCP-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Tudor/PWWP/MBT | Chromo domain-like | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | Molybdenum cofactor biosynthesis proteins | 1 | 1 |  |
| Histone-fold | Ubiquitin-like | 1 | 1 |  |
| ARM repeat | EF-hand | 1 | 1 |  |
| ARID-like | Clavaminate synthase-like | 1 | 1 |  |
| Acid phosphatase/Vanadium-dependent haloperoxidase | Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | 1 |  |
| F-box domain | LigB-like | 1 | 1 |  |
| WW domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Ubiquitin-like | Hect, E3 ligase catalytic domain | 1 | 1 |  |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 1 | 1 |  |
| Histone-fold | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| UBC-like | UBA-like | 1 | 1 |  |
| Ribosomal protein S2 | F1F0 ATP synthase subunit A | 1 | 1 |  |
| Chaperone J-domain | RNA-binding domain, RBD | 1 | 1 |  |
| Phosphoenolpyruvate/pyruvate domain | Nucleic acid-binding proteins | 1 | 1 |  |
| beta-Galactosidase/glucuronidase domain | beta-Galactosidase/glucuronidase domain | 1 | 1 |  |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | Translation proteins | 1 | 1 |  |
| Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 |  |
| Chelatase | Chlorophyll a-b binding protein | 1 | 1 |  |
| Protein kinase-like (PK-like) | Ribonuclease H-like | 1 | 1 |  |
| Cytochrome P450 | Thioredoxin-like | 1 | 1 |  |
| Histone-fold | ARM repeat | 1 | 1 |  |
| eEF-1beta-like | eEF-1beta-like | 1 | 1 |  |
| eIF2alpha middle domain-like | eIF-2-alpha, C-terminal domain | 1 | 1 |  |
| alpha-D-mannose-specific plant lectins | Type II DNA topoisomerase | 1 | 1 |  |
| Tex N-terminal region-like | RuvA domain 2-like | 1 | 1 |  |
| WRKY DNA-binding domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| RNA-binding domain, RBD | beta-sandwich domain of Sec23/24 | 1 | 1 |  |
| Histone-fold | L domain-like | 1 | 1 |  |
| E set domains | Cytochrome b5-like heme/steroid binding domain | 1 | 1 |  |
| BAR/IMD domain-like | PH domain-like | 1 | 1 |  |
| UBC-like | Cyclin-like | 1 | 1 |  |
| NTF2-like | Oxysterol-binding protein-like | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | CO dehydrogenase flavoprotein C-terminal domain-like | 1 | 1 |  |
| Clathrin heavy-chain terminal domain | ARM repeat | 1 | 1 |  |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | L30e-like | 1 | 1 |  |
| TGS-like | Class II aaRS ABD-related | 1 | 1 |  |
| Oxidoreductase molybdopterin-binding domain | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | Calcium ATPase, transmembrane domain M | 1 | 1 |  |
| ARM repeat | Concanavalin A-like lectins/glucanases | 1 | 1 |  |
| Rhodanese/Cell cycle control phosphatase | SMAD/FHA domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | HAD-like | 1 | 1 |  |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
| SNARE-like | Domain of the SRP/SRP receptor G-proteins | 1 | 1 |  |
| Thioredoxin-like | MFS general substrate transporter | 1 | 1 |  |
| Agglutinin | Aerolisin/ETX pore-forming domain | 1 | 1 |  |
| DNA-binding domain | Calcium ATPase, transmembrane domain M | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Pectin lyase-like | 1 | 1 |  |
| Enolase C-terminal domain-like | alpha/beta-Hydrolases | 1 | 1 |  |
| Myosin rod fragments | Tropomyosin | 1 | 1 |  |
| Endosomal sorting complex assembly domain | VPS28 C-terminal domain-like | 1 | 1 |  |
| Thioredoxin-like | Aquaporin-like | 1 | 1 |  |
| Phospholipase C/P1 nuclease | Phospholipase C/P1 nuclease | 1 | 1 |  |
| Periplasmic binding protein-like II | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| Zinc hairpin stack | Zinc hairpin stack | 1 | 1 |  |
| Nucleic acid-binding proteins | eIF-2-alpha, C-terminal domain | 1 | 1 |  |
| (Trans)glycosidases | HMG-box | 1 | 1 |  |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | Glutamyl tRNA-reductase dimerization domain | 1 | 1 |  |
| CAD & PB1 domains | RING/U-box | 1 | 1 |  |
| Transferrin receptor-like dimerisation domain | Transferrin receptor-like dimerisation domain | 1 | 1 |  |
| Actin-like ATPase domain | Trypsin-like serine proteases | 1 | 1 |  |
| FAD-linked oxidoreductase | FAD-linked oxidoreductase | 1 | 1 |  |
| Carbamate kinase-like | ACT-like | 1 | 1 |  |
| E set domains | AMPKBI-like | 1 | 1 |  |
| Casein kinase II beta subunit | Casein kinase II beta subunit | 1 | 1 |  |
| Homeodomain-like | PYP-like sensor domain (PAS domain) | 1 | 1 |  |
| Ricin B-like lectins | Glycosyl hydrolase domain | 1 | 1 |  |
| Cytochrome P450 | SGNH hydrolase | 1 | 1 |  |
| Tudor/PWWP/MBT | DNA repair protein MutS, domain III | 1 | 1 |  |
| DNase I-like | L domain-like | 1 | 1 |  |
| GroES-like | E set domains | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | MesJ substrate recognition domain-like | 1 | 1 |  |
| Nucleoside hydrolase | Nucleoside hydrolase | 1 | 1 |  |
| Protein kinase-like (PK-like) | Pectin lyase-like | 1 | 1 |  |
| ArfGap/RecO-like zinc finger | C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | 1 |  |
| EreA/ChaN-like | ACT-like | 1 | 1 |  |
| Surp module (SWAP domain) | ENTH/VHS domain | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | Translational machinery components | 1 | 1 |  |
| PurM N-terminal domain-like | PurM C-terminal domain-like | 1 | 1 |  |
| FMN-linked oxidoreductases | Clavaminate synthase-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Sec63 N-terminal domain-like | 1 | 1 |  |
| Argininosuccinate synthetase, C-terminal domain | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| Oxidoreductase molybdopterin-binding domain | E set domains | 1 | 1 |  |
| Mitochondrial carrier | MFS general substrate transporter | 1 | 1 |  |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | SAICAR synthase-like | 1 | 1 |  |
| Helical domain of Sec23/24 | Helical domain of Sec23/24 | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | GMP synthetase C-terminal dimerisation domain | 1 | 1 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
| Creatinase/aminopeptidase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Domain of the SRP/SRP receptor G-proteins | Signal peptide-binding domain | 1 | 1 |  |
| SNARE-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 1 | 1 |  |
| Bacterial photosystem II reaction centre, L and M subunits | Photosystem II antenna protein-like | 1 | 1 |  |
| Thioredoxin-like | Ubiquitin-like | 1 | 1 |  |
| Outer arm dynein light chain 1 | RNI-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | ARID-like | 1 | 1 |  |
| EF-hand | FMN-linked oxidoreductases | 1 | 1 |  |
| SBT domain | SBT domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | Carbonic anhydrase | 1 | 1 |  |
| Oxidoreductase molybdopterin-binding domain | Riboflavin synthase domain-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Amine oxidase catalytic domain | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 |  |
| Quinoprotein alcohol dehydrogenase-like | Tricorn protease domain 2 | 1 | 1 |  |
| ACT-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| L30e-like | Actin-crosslinking proteins | 1 | 1 |  |
| Class I glutamine amidotransferase-like | PP2C-like | 1 | 1 |  |
| Macro domain-like | Macro domain-like | 1 | 1 |  |
| Class II aaRS ABD-related | C-terminal domain of ProRS | 1 | 1 |  |
| PLP-dependent transferases | PIN domain-like | 1 | 1 |  |
| Ribosomal protein S19 | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Rhomboid-like | Rhomboid-like | 1 | 1 |  |
| Heme oxygenase-like | HAD-like | 1 | 1 |  |
| FYSH domain | Hypothetical protein AF0491, middle domain | 1 | 1 |  |
| PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | FMN-linked oxidoreductases | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 1 | 1 |  |
| beta-sandwich domain of Sec23/24 | Acid proteases | 1 | 1 |  |
| Argininosuccinate synthetase, C-terminal domain | Argininosuccinate synthetase, C-terminal domain | 1 | 1 |  |
| Saposin | Protein kinase-like (PK-like) | 1 | 1 |  |
| Ammonium transporter | Ammonium transporter | 1 | 1 |  |
| alpha/beta-Hydrolases | L domain-like | 1 | 1 |  |
| beta-N-acetylhexosaminidase-like domain | (Trans)glycosidases | 1 | 1 |  |
| ARM repeat | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| PH domain-like | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| ISP domain | Chlorophyll a-b binding protein | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Homeodomain-like | 1 | 1 |  |
| FAD-linked oxidases, C-terminal domain | FAD-linked oxidases, C-terminal domain | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | 1 |  |
| Acyl-CoA N-acyltransferases (Nat) | BRCT domain | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| CO dehydrogenase flavoprotein C-terminal domain-like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Cupredoxins | 1 | 1 |  |
| Ribonuclease H-like | RING/U-box | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Nucleotide-binding domain | 1 | 1 |  |
| BAR/IMD domain-like | BAR/IMD domain-like | 1 | 1 |  |
| Protein kinase-like (PK-like) | Globin-like | 1 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | (Trans)glycosidases | 1 | 1 |  |
| DNase I-like | Cytochrome P450 | 1 | 1 |  |
| HAND domain of the nucleosome remodeling ATPase ISWI | Homeodomain-like | 1 | 1 |  |
| PH domain-like | RCC1/BLIP-II | 1 | 1 |  |
| Seven-hairpin glycosidases | Seven-hairpin glycosidases | 1 | 1 |  |
| Hypothetical protein AF0491, middle domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| Translation proteins | ThrRS/AlaRS common domain | 1 | 1 |  |
| Trimeric LpxA-like enzymes | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| Calcium ATPase, transmembrane domain M | DNA-binding pseudobarrel domain | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Ricin B-like lectins | 1 | 1 |  |
| SAP domain | Nucleic acid-binding proteins | 1 | 1 |  |
| L domain-like | NAD-binding domain of HMG-CoA reductase | 1 | 1 |  |
| Oxygen-evolving enhancer protein 3, | Cyclophilin-like | 1 | 1 |  |
| L-aspartase-like | Class II aaRS and biotin synthetases | 1 | 1 |  |
| UBA-like | NSFL1 (p97 ATPase) cofactor p47, SEP domain | 1 | 1 |  |
| FAD/NAD(P)-binding domain | ARM repeat | 1 | 1 |  |
| Tricorn protease domain 2 | WD40 repeat-like | 1 | 1 |  |
| Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
| Substrate-binding domain of HMG-CoA reductase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 1 | 1 |  |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | Nucleic acid-binding proteins | 1 | 1 |  |
| Thioredoxin-like | "Winged helix" DNA-binding domain | 1 | 1 |  |
| FAD/NAD(P)-binding domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| L domain-like | Substrate-binding domain of HMG-CoA reductase | 1 | 1 |  |
| DNA-binding domain | Cupredoxins | 1 | 1 |  |
| BAR/IMD domain-like | ArfGap/RecO-like zinc finger | 1 | 1 |  |
| Nucleic acid-binding proteins | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Cysteine proteinases | PRTase-like | 1 | 1 |  |
| EF-hand | Calponin-homology domain, CH-domain | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | Subtilisin-like | 1 | 1 |  |
| Isocitrate/Isopropylmalate dehydrogenase-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| GroEL-intermediate domain like | GroEL-intermediate domain like | 1 | 1 |  |
| "Winged helix" DNA-binding domain | Sec63 N-terminal domain-like | 1 | 1 |  |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | L domain-like | 1 | 1 |  |
| UBA-like | Hect, E3 ligase catalytic domain | 1 | 1 |  |
| tRNA-binding arm | Class II aaRS and biotin synthetases | 1 | 1 |  |
| PA domain | Growth factor receptor domain | 1 | 1 |  |
| Nucleotidylyl transferase | Nucleotidylyl transferase | 1 | 1 |  |
| At5g01610-like | Formate dehydrogenase/DMSO reductase, domains 1-3 | 1 | 1 |  |
| Metallo-dependent phosphatases | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | 1 |  |
| Toll/Interleukin receptor TIR domain | HSP20-like chaperones | 1 | 1 |  |
| ISP domain | Bet v1-like | 1 | 1 |  |
| Cysteine proteinases | DNA breaking-rejoining enzymes | 1 | 1 |  |
| RBP11-like subunits of RNA polymerase | RBP11-like subunits of RNA polymerase | 1 | 1 |  |
| ENTH/VHS domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Retrovirus zinc finger-like domains | RCC1/BLIP-II | 1 | 1 |  |
| MoeA N-terminal region -like | MoeA N-terminal region -like | 1 | 1 |  |
| HAD-like | alpha/beta-Hydrolases | 1 | 1 |  |
| HMA, heavy metal-associated domain | PLP-dependent transferases | 1 | 1 |  |
| FYVE/PHD zinc finger | ARM repeat | 1 | 1 |  |
| Nucleotidyltransferase | Poly A polymerase C-terminal region-like | 1 | 1 |  |
| Ribosomal protein S5 domain 2-like | (Trans)glycosidases | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Cullin repeat-like | 1 | 1 |  |
| RNA-binding domain, RBD | Phospholipase D/nuclease | 1 | 1 |  |
| LEA14-like | LEA14-like | 1 | 1 |  |
| Ribosomal proteins L15p and L18e | Ribosomal proteins L15p and L18e | 1 | 1 |  |
| PP2C-like | Trypsin-like serine proteases | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | vWA-like | 1 | 1 |  |
| Sec7 domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Cryptochrome/photolyase, N-terminal domain | Cryptochrome/photolyase, N-terminal domain | 1 | 1 |  |
| Protein kinase-like (PK-like) | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| FAD/NAD(P)-binding domain | Smc hinge domain | 1 | 1 |  |
| Acid proteases | Glutamine synthetase/guanido kinase | 1 | 1 |  |
| Kelch motif | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| TPR-like | HSP20-like chaperones | 1 | 1 |  |
| Dcp2 domain-like | Ribonuclease H-like | 1 | 1 |  |
| Cap-Gly domain | Cap-Gly domain | 1 | 1 |  |
| PH domain-like | PH domain-like | 1 | 1 |  |
| Ribonuclease H-like | Sm-like ribonucleoproteins | 1 | 1 |  |
| C-terminal UvrC-binding domain of UvrB | ApaG-like | 1 | 1 |  |
| Helical domain of Sec23/24 | ARM repeat | 1 | 1 |  |
| Creatinase/aminopeptidase | Creatinase/prolidase N-terminal domain | 1 | 1 |  |
| C-terminal, gelsolin-like domain of Sec23/24 | VHP, Villin headpiece domain | 1 | 1 |  |
| Ypt/Rab-GAP domain of gyp1p | Mitochondrial carrier | 1 | 1 |  |
| Formin homology 2 domain (FH2 domain) | Oxysterol-binding protein-like | 1 | 1 |  |
| Acid proteases | PIN domain-like | 1 | 1 |  |
| SWIB/MDM2 domain | SGNH hydrolase | 1 | 1 |  |
| Homeodomain-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| DNA-glycosylase | Nudix | 1 | 1 |  |
| WD40 repeat-like | Galactose oxidase, central domain | 1 | 1 |  |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | alpha-helical ferredoxin | 1 | 1 |  |
| DLC | DLC | 1 | 1 |  |
| Cation efflux protein transmembrane domain-like | DNA-binding domain | 1 | 1 |  |
| F-box domain | Ankyrin repeat | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | Calpain large subunit, middle domain (domain III) | 1 | 1 |  |
| WD40 repeat-like | Bromodomain | 1 | 1 |  |
| Calponin-homology domain, CH-domain | ARM repeat | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | HD-domain/PDEase-like | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | DNase I-like | 1 | 1 |  |
| Carbamate kinase-like | ALDH-like | 1 | 1 |  |
| SBT domain | Ankyrin repeat | 1 | 1 |  |
| UraD-Like | Transthyretin (synonym: prealbumin) | 1 | 1 |  |
| Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | ACT-like | 1 | 1 |  |
| PheT/TilS domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
| HAD-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Purine and uridine phosphorylases | Purine and uridine phosphorylases | 1 | 1 |  |
| RNA-binding domain, RBD | alpha/beta-Hydrolases | 1 | 1 |  |
| Ribosomal protein S3 C-terminal domain | Ribosomal protein S3 C-terminal domain | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | FMN-linked oxidoreductases | 1 | 1 |  |
| Prokaryotic type KH domain (KH-domain type II) | ARM repeat | 1 | 1 |  |
| ADC-like | ADC-like | 1 | 1 |  |
| Cysteine-rich domain | NAD kinase/diacylglycerol kinase-like | 1 | 1 |  |
| Lysozyme-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Photosystem II antenna protein-like | Photosystem II antenna protein-like | 1 | 1 |  |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleic acid-binding proteins | 1 | 1 |  |
| Ubiquitin-like | Cysteine proteinases | 1 | 1 |  |
| FMN-linked oxidoreductases | Protein kinase-like (PK-like) | 1 | 1 |  |
| Creatinase/aminopeptidase | "Winged helix" DNA-binding domain | 1 | 1 |  |
| Retrovirus zinc finger-like domains | Protein kinase-like (PK-like) | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Cupredoxins | 1 | 1 |  |
| Aspartate/glutamate racemase | Aspartate/glutamate racemase | 1 | 1 |  |
| PHL pollen allergen | Protein kinase-like (PK-like) | 1 | 1 |  |
| L9 N-domain-like | Ribosomal protein L9 C-domain | 1 | 1 |  |
| CBS-domain pair | Inosine monophosphate dehydrogenase (IMPDH) | 1 | 1 |  |
| Enolase C-terminal domain-like | Enolase C-terminal domain-like | 1 | 1 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Actin-crosslinking proteins | 1 | 1 |  |
| N-terminal, heterodimerisation domain of RBP7 (RpoE) | Nucleic acid-binding proteins | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | DNA-binding domain | 1 | 1 |  |
| Ribulose-phoshate binding barrel | RING/U-box | 1 | 1 |  |
| IlvD/EDD N-terminal domain-like | LeuD/IlvD-like | 1 | 1 |  |
| Surp module (SWAP domain) | Surp module (SWAP domain) | 1 | 1 |  |
| Hypothetical protein SAV1430 | Hypothetical protein SAV1430 | 1 | 1 |  |
| C2 domain (Calcium/lipid-binding domain, CaLB) | DNase I-like | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | Formate dehydrogenase/DMSO reductase, domains 1-3 | 1 | 1 |  |
| Translational machinery components | Cupredoxins | 1 | 1 |  |
| PLP-binding barrel | PLP-binding barrel | 1 | 1 |  |
| Tubby C-terminal domain-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| "Winged helix" DNA-binding domain | HAD-like | 1 | 1 |  |
| POZ domain | Chaperone J-domain | 1 | 1 |  |
| LuxS/MPP-like metallohydrolase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 1 | 1 |  |
| Sigma3 and sigma4 domains of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 1 | 1 |  |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| ARM repeat | Thioredoxin-like | 1 | 1 |  |
| NAD kinase/diacylglycerol kinase-like | NAD kinase/diacylglycerol kinase-like | 1 | 1 |  |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | F-box domain | 1 | 1 |  |
| Thioredoxin-like | beta and beta-prime subunits of DNA dependent RNA-polymerase | 1 | 1 |  |
| Rhodanese/Cell cycle control phosphatase | (Phosphotyrosine protein) phosphatases II | 1 | 1 |  |
| Scaffolding protein gpD of bacteriophage procapsid | ssDNA viruses | 1 | 1 |  |
| RING/U-box | UBA-like | 1 | 1 |  |
| Carbonic anhydrase | Carbonic anhydrase | 1 | 1 |  |
| Single hybrid motif | CoA-dependent acyltransferases | 1 | 1 |  |
| RmlC-like cupins | Thioredoxin-like | 1 | 1 |  |
| ssDNA viruses | ssDNA viruses | 1 | 1 |  |
| Release factor | Release factor | 1 | 1 |  |
| CheY-like | PA domain | 1 | 1 |  |
| 2Fe-2S ferredoxin-like | CO dehydrogenase ISP C-domain like | 1 | 1 |  |
| Cytochrome b5-like heme/steroid binding domain | Riboflavin synthase domain-like | 1 | 1 |  |
| Ribonuclease H-like | Toll/Interleukin receptor TIR domain | 1 | 1 |  |
| (Trans)glycosidases | Translational machinery components | 1 | 1 |  |
| Tubulin nucleotide-binding domain-like | Six-hairpin glycosidases | 1 | 1 |  |
| Isocitrate/Isopropylmalate dehydrogenase-like | Heme-dependent peroxidases | 1 | 1 |  |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | ACT-like | 1 | 1 |  |
| NTF2-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| ALDH-like | Cytochrome P450 | 1 | 1 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | 1 | 1 |  |
| FYVE/PHD zinc finger | Clavaminate synthase-like | 1 | 1 |  |
| Hypothetical protein SAV1430 | Fe-S cluster assembly (FSCA) domain-like | 1 | 1 |  |
| HSP90 C-terminal domain | HSP90 C-terminal domain | 1 | 1 |  |
| Dihydropteroate synthetase-like | Dihydropteroate synthetase-like | 1 | 1 |  |
| UBC-like | Protein kinase-like (PK-like) | 1 | 1 |  |
| Leucine zipper domain | Leucine zipper domain | 1 | 1 |  |
| Sm-like ribonucleoproteins | Sm-like ribonucleoproteins | 1 | 1 |  |
| Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 |  |
| Cysteine proteinases | Actin-like ATPase domain | 1 | 1 |  |
| Dihydrofolate reductase-like | Thymidylate synthase/dCMP hydroxymethylase | 1 | 1 |  |
| Ribonuclease H-like | RuvA domain 2-like | 1 | 1 |  |
| TGS-like | ThrRS/AlaRS common domain | 1 | 1 |  |
| Zn-binding ribosomal proteins | Zn-binding ribosomal proteins | 1 | 1 |  |
| alpha/beta knot | Nucleic acid-binding proteins | 1 | 1 |  |
| Amidase signature (AS) enzymes | Amidase signature (AS) enzymes | 1 | 1 |  |
| Histone-fold | Tubulin C-terminal domain-like | 1 | 1 |  |
| PH domain-like | WD40 repeat-like | 1 | 1 |  |
| Nop domain | Nop domain | 1 | 1 |  |
| Aldolase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| Tubulin C-terminal domain-like | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 1 | 1 |  |
| TPR-like | GroES-like | 1 | 1 |  |
| L domain-like | Lysozyme-like | 1 | 1 |  |
| Cystatin/monellin | Ubiquitin-like | 1 | 1 |  |
| Prim-pol domain | Prim-pol domain | 1 | 1 |  |
| Clavaminate synthase-like | NAD-binding domain of HMG-CoA reductase | 1 | 1 |  |
| Thioredoxin-like | ERP29 C domain-like | 1 | 1 |  |
| Saposin | Phosphoglycerate mutase-like | 1 | 1 |  |
| Glycoside hydrolase/deacetylase | Galactose mutarotase-like | 1 | 1 |  |
| Pectin lyase-like | Mitochondrial carrier | 1 | 1 |  |
| FAD/NAD(P)-binding domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | SNARE fusion complex | 1 | 1 |  |
| (2r)-phospho-3-sulfolactate synthase ComA | (2r)-phospho-3-sulfolactate synthase ComA | 1 | 1 |  |
| MFS general substrate transporter | HAD-like | 1 | 1 |  |
| Nucleic acid-binding proteins | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
| TAZ domain | FYVE/PHD zinc finger | 1 | 1 |  |
| HAD-like | dsRNA-binding domain-like | 1 | 1 |  |
| dsRNA-binding domain-like | FKBP-like | 1 | 1 |  |
| Chalcone isomerase | Thiolase-like | 1 | 1 |  |
| PAZ domain | PAZ domain | 1 | 1 |  |
| Histone-fold | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
| RNI-like | PP2C-like | 1 | 1 |  |
| Kelch motif | Nucleotidylyl transferase | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | PP2C-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 1 | 1 |  |
| L domain-like | Terpenoid cyclases/Protein prenyltransferases | 1 | 1 |  |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | Fe,Mn superoxide dismutase (SOD), C-terminal domain | 1 | 1 |  |
| Flavoproteins | Riboflavin synthase domain-like | 1 | 1 |  |
| Cullin repeat-like | Tubulin nucleotide-binding domain-like | 1 | 1 |  |
| Cdc48 domain 2-like | Cdc48 domain 2-like | 1 | 1 |  |
| N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | (Trans)glycosidases | 1 | 1 |  |
| PLP-dependent transferases | Acid proteases | 1 | 1 |  |
| FAD-binding/transporter-associated domain-like | CO dehydrogenase molybdoprotein N-domain-like | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | Toll/Interleukin receptor TIR domain | 1 | 1 |  |
| S-adenosyl-L-methionine-dependent methyltransferases | PLP-dependent transferases | 1 | 1 |  |
| DNA-binding pseudobarrel domain | Pectin lyase-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | UBC-like | 1 | 1 |  |
| Clavaminate synthase-like | eIF4e-like | 1 | 1 |  |
| Thioredoxin-like | alpha/beta-Hydrolases | 1 | 1 |  |
| BRCT domain | FYVE/PHD zinc finger | 1 | 1 |  |
| Acetyl-CoA synthetase-like | NAD(P)-linked oxidoreductase | 1 | 1 |  |
| Adenine nucleotide alpha hydrolases-like | DHS-like NAD/FAD-binding domain | 1 | 1 |  |
| Cysteine proteinases | Purine and uridine phosphorylases | 1 | 1 |  |
| GAF domain-like | Homodimeric domain of signal transducing histidine kinase | 1 | 1 |  |
| (Phosphotyrosine protein) phosphatases II | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 |  |
| NAD-binding domain of HMG-CoA reductase | Toll/Interleukin receptor TIR domain | 1 | 1 |  |
| L-aspartase-like | WD40 repeat-like | 1 | 1 |  |
| Putative DNA-binding domain | Putative DNA-binding domain | 1 | 1 |  |
| Translation proteins SH3-like domain | Translation proteins SH3-like domain | 1 | 1 |  |
| Leukotriene A4 hydrolase N-terminal domain | Barwin-like endoglucanases | 1 | 1 |  |
| C-terminal autoproteolytic domain of nucleoporin nup98 | C-terminal autoproteolytic domain of nucleoporin nup98 | 1 | 1 |  |
| Clathrin adaptor appendage domain | Subdomain of clathrin and coatomer appendage domain | 1 | 1 |  |
| SAP domain | CCCH zinc finger | 1 | 1 |  |
| Glycolipid transfer protein, GLTP | Glycolipid transfer protein, GLTP | 1 | 1 |  |
| NAD(P)-linked oxidoreductase | PHL pollen allergen | 1 | 1 |  |
| Ribosomal protein L1 | Ribosomal protein L1 | 1 | 1 |  |
| Peptidase/esterase 'gauge' domain | Peptidase/esterase 'gauge' domain | 1 | 1 |  |
| Metallo-dependent phosphatases | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 |  |
| CO dehydrogenase ISP C-domain like | CO dehydrogenase flavoprotein C-terminal domain-like | 1 | 1 |  |
| Actin-like ATPase domain | BRCT domain | 1 | 1 |  |
| Concanavalin A-like lectins/glucanases | BEACH domain | 1 | 1 |  |
| Outer arm dynein light chain 1 | Protein kinase-like (PK-like) | 1 | 1 |  |
| FAH | FAH | 1 | 1 |  |
| FAD/NAD(P)-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
| Tubulin C-terminal domain-like | Tubulin C-terminal domain-like | 1 | 1 |  |
| Eukaryotic type KH-domain (KH-domain type I) | Mitochondrial carrier | 1 | 1 |  |
| Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
| PreATP-grasp domain | Methylglyoxal synthase-like | 1 | 1 |  |
| Cdc48 domain 2-like | Cupredoxins | 1 | 1 |  |
| UBA-like | post-AAA+ oligomerization domain-like | 1 | 1 |  |
| MoeA N-terminal region -like | Molybdenum cofactor biosynthesis proteins | 1 | 1 |  |
| Cytochrome P450 | Cupredoxins | 1 | 1 |  |
| Caspase-like | Caspase-like | 1 | 1 |  |
| RNA-binding domain, RBD | F-box domain | 1 | 1 |  |
| Granulin repeat | Formin homology 2 domain (FH2 domain) | 1 | 1 |  |
| Ribosomal L27 protein-like | RNA-binding domain, RBD | 1 | 1 |  |
| Ribosomal protein S6 | Peptide methionine sulfoxide reductase | 1 | 1 |  |
| ADP-ribosylation | ADP-ribosylation | 1 | 1 |  |
| SMAD/FHA domain | PIN domain-like | 1 | 1 |  |
| L-aspartase-like | Class II aaRS ABD-related | 1 | 1 |  |
| RNI-like | Substrate-binding domain of HMG-CoA reductase | 1 | 1 |  |
| PRTase-like | Ribulose-phoshate binding barrel | 1 | 1 |  |
| Dcp2 domain-like | Nudix | 1 | 1 |  |
| Arabinanase/levansucrase/invertase | Arabinanase/levansucrase/invertase | 1 | 1 |  |
| Clavaminate synthase-like | Substrate-binding domain of HMG-CoA reductase | 1 | 1 |  |
| TATA-box binding protein-like | DNA-glycosylase | 1 | 1 |  |
| Phospholipase D/nuclease | DNA-binding domain | 1 | 1 |  |
| Cullin repeat-like | cAMP-binding domain-like | 1 | 1 |  |
| FYSH domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| L domain-like | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
| eEF1-gamma domain | RmlC-like cupins | 1 | 1 |  |
| SMAD/FHA domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| Chaperone J-domain | Thioredoxin-like | 1 | 1 |  |
| CO dehydrogenase flavoprotein C-terminal domain-like | Molybdenum cofactor-binding domain | 1 | 1 |  |
| YjeF N-terminal domain-like | FMN-binding split barrel | 1 | 1 |  |
| Molybdopterin synthase subunit MoaE | NAD(P)-linked oxidoreductase | 1 | 1 |  |
| XRCC4, N-terminal domain | XRCC4, C-terminal oligomerization domain | 1 | 1 |  |
| Ankyrin repeat | (Trans)glycosidases | 1 | 1 |  |
| P-loop containing nucleoside triphosphate hydrolases | Chaperone J-domain | 1 | 1 |  |
| Ribosomal protein L11, C-terminal domain | Ribosomal protein L11, C-terminal domain | 1 | 1 |  |
| Eukaryotic RPB5 N-terminal domain | Eukaryotic RPB5 N-terminal domain | 1 | 1 |  |
| Activator of Hsp90 ATPase, Aha1 | Bet v1-like | 1 | 1 |  |
| Ligand-binding domain in the NO signalling and Golgi transport | alpha/beta-Hydrolases | 1 | 1 |  |
| Metallo-hydrolase/oxidoreductase | Metallo-hydrolase/oxidoreductase | 1 | 1 |  |
| RING/U-box | PUA domain-like | 1 | 1 |  |
| SET domain | Chromo domain-like | 1 | 1 |  |
| Nucleotidylyl transferase | Nucleic acid-binding proteins | 1 | 1 |  |
| PUA domain-like | SET domain | 1 | 1 |  |
| RNA-binding domain, RBD | PWI domain | 1 | 1 |  |
| beta-carbonic anhydrase, cab | beta-carbonic anhydrase, cab | 1 | 1 |  |
| Cytochrome P450 | Sec7 domain | 1 | 1 |  |
| Cysteine proteinases | Calpain large subunit, middle domain (domain III) | 1 | 1 |  |
| L30e-like | Cupredoxins | 1 | 1 |  |
| F-box domain | NTF2-like | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 1 | 1 |  |
| Chaperone J-domain | beta-beta-alpha zinc fingers | 1 | 1 |  |
| POZ domain | WD40 repeat-like | 1 | 1 |  |
| DNA-binding domain | Actin depolymerizing proteins | 1 | 1 |  |
| Ribonuclease H-like | Histone-fold | 1 | 1 |  |
| Thiolase-like | UDP-Glycosyltransferase/glycogen phosphorylase | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | Band 7/SPFH domain | 1 | 1 |  |
| Ribosomal protein L22 | ERP29 C domain-like | 1 | 1 |  |
| FYVE/PHD zinc finger | Homeodomain-like | 1 | 1 |  |
| DHS-like NAD/FAD-binding domain | alpha/beta-Hydrolases | 1 | 1 |  |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | NAC domain | 1 | 1 |  |
| Galactose mutarotase-like | Starch-binding domain-like | 1 | 1 |  |
| Thioredoxin-like | VC0467-like | 1 | 1 |  |
| BAR/IMD domain-like | SH3-domain | 1 | 1 |  |
| Obg GTP-binding protein N-terminal domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
| RNA-binding domain, RBD | Cation efflux protein transmembrane domain-like | 1 | 1 |  |
| PH domain-like | FYVE/PHD zinc finger | 1 | 1 |  |
| F-box domain | Actin-like ATPase domain | 1 | 1 |  |
| LysM domain | Protein kinase-like (PK-like) | 1 | 1 |  |
| UDP-Glycosyltransferase/glycogen phosphorylase | L domain-like | 1 | 1 |  |
| F-box domain | Clavaminate synthase-like | 1 | 1 |  |
| Acyl-CoA binding protein | Kelch motif | 1 | 1 |  |
| Galactose oxidase, central domain | Galactose oxidase, central domain | 1 | 1 |  |
| Urease, beta-subunit | Composite domain of metallo-dependent hydrolases | 1 | 1 |  |
| Single hybrid motif | Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 1 | 1 |  |
| LDH C-terminal domain-like | LDH C-terminal domain-like | 1 | 1 |  |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
| ARM repeat | POZ domain | 1 | 1 |  |
| NAD(P)-binding Rossmann-fold domains | Succinyl-CoA synthetase domains | 1 | 1 |  |
| L domain-like | FMN-linked oxidoreductases | 1 | 1 |  |
| AN1-like Zinc finger | beta-beta-alpha zinc fingers | 1 | 1 |  |
| GroEL equatorial domain-like | alpha/beta-Hydrolases | 1 | 1 |  |
| 4Fe-4S ferredoxins | Formate dehydrogenase/DMSO reductase, domains 1-3 | 1 | 1 |  |
| TPR-like | CRAL/TRIO N-terminal domain | 1 | 1 |  |
| RNA-binding domain, RBD | PLP-dependent transferases | 1 | 1 |  |
| Ribonuclease H-like | HRDC-like | 1 | 1 |  |
| PX domain | TPR-like | 1 | 1 |  |
| Macro domain-like | Zn-dependent exopeptidases | 1 | 1 |  |
| DNA-binding domain | Acid proteases | 1 | 1 |  |