Domain combination pairs in Pelodiscus sinensis 76_1.0

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

• For a list of unique full length architectures for this genome click here (can be slow).

• Remove domain pairs for which there is already a structure in the PDB
• Remove domain pairs which occur in any other genomes (slow)
• Remove domain pairs which are not adjacent to each other
• Remove different strains from the list of genomes compared to

Jump to [ Top of page · Add/remove domain pairs · Domain combination pairs ]

Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.

Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes ]

Domain combination pairs

2374 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	462	159
Immunoglobulin	Immunoglobulin	334	107
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	155	50
Fibronectin type III	Fibronectin type III	132	81
KRAB domain (Kruppel-associated box)	beta-beta-alpha zinc fingers	116	41
EGF/Laminin	EGF/Laminin	115	95
RING/U-box	B-box zinc-binding domain	107	21
DNase I-like	DNA/RNA polymerases	89	2
Cadherin-like	Cadherin-like	85	32
Immunoglobulin	Fibronectin type III	82	48
RNA-binding domain, RBD	RNA-binding domain, RBD	76	31
Homeodomain-like	Homeodomain-like	75	19
DBL homology domain (DH-domain)	PH domain-like	70	38
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	69	24
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	69	28
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	68	10
TPR-like	TPR-like	67	26
PH domain-like	PH domain-like	66	31
RING/U-box	Concanavalin A-like lectins/glucanases	62	7
Actin-like ATPase domain	Actin-like ATPase domain	58	13
PH domain-like	Second domain of FERM	57	25
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	57	37
ARM repeat	ARM repeat	55	27
TSP-1 type 1 repeat	TSP-1 type 1 repeat	55	35
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	54	3
Ubiquitin-like	PH domain-like	51	21
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	50	5
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	49	13
POZ domain	Kelch motif	48	6
HAD-like	Calcium ATPase, transmembrane domain M	47	12
PDZ domain-like	PDZ domain-like	47	28
Growth factor receptor domain	EGF/Laminin	47	44
POZ domain	beta-beta-alpha zinc fingers	46	21
EGF/Laminin	Concanavalin A-like lectins/glucanases	44	35
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	43	10
SH3-domain	PH domain-like	43	27
Calcium ATPase, transduction domain A	HAD-like	43	10
Growth factor receptor domain	Growth factor receptor domain	43	36
SH3-domain	SH3-domain	43	32
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	43	10
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	43	10
Ubiquitin-like	Second domain of FERM	43	16
SH2 domain	SH3-domain	43	22
Immunoglobulin	Concanavalin A-like lectins/glucanases	42	9
Complement control module/SCR domain	Complement control module/SCR domain	41	32
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	41	9
L domain-like	L domain-like	40	21
BAR/IMD domain-like	SH3-domain	40	12
EF-hand	EF-hand	39	20
L domain-like	Immunoglobulin	34	17
Spermadhesin, CUB domain	Spermadhesin, CUB domain	34	26
Sema domain	Plexin repeat	34	12
Voltage-gated potassium channels	Voltage-gated potassium channels	34	8
SH2 domain	PH domain-like	33	23
Protein kinase-like (PK-like)	PH domain-like	32	18
Tudor/PWWP/MBT	Tudor/PWWP/MBT	32	22
Fibronectin type III	Protein kinase-like (PK-like)	32	21
LDL receptor-like module	LDL receptor-like module	31	28
Immunoglobulin	Protein kinase-like (PK-like)	31	22
SH2 domain	Protein kinase-like (PK-like)	30	13
Spectrin repeat	Spectrin repeat	30	23
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	30	15
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	30	18
SH3-domain	Protein kinase-like (PK-like)	30	12
PH domain-like	GTPase activation domain, GAP	30	14
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	30	8
WD40 repeat-like	WD40 repeat-like	28	16
Cysteine-rich domain	Protein kinase-like (PK-like)	28	13
Protein kinase-like (PK-like)	ARM repeat	27	18
Cyclin-like	Cyclin-like	27	7
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	27	15
Ankyrin repeat	Ankyrin repeat	26	19
PDZ domain-like	PH domain-like	26	14
E set domains	E set domains	25	12
Thioredoxin-like	GST C-terminal domain-like	25	5
C-type lectin-like	C-type lectin-like	25	14
SRCR-like	SRCR-like	25	19
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	24	12
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	24	17
POZ domain	Voltage-gated potassium channels	24	3
PH domain-like	(Phosphotyrosine protein) phosphatases II	23	10
vWA-like	vWA-like	23	19
WW domain	WW domain	23	20
lambda repressor-like DNA-binding domains	Homeodomain-like	23	10
Concanavalin A-like lectins/glucanases	Fibronectin type III	23	12
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	22	5
Intermediate filament protein, coiled coil region	Intermediate filament protein, coiled coil region	22	10
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	22	8
Ribonuclease H-like	DNA/RNA polymerases	22	13
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	22	2
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	22	5
EF-hand	PLC-like phosphodiesterases	22	16
FYVE/PHD zinc finger	FYVE/PHD zinc finger	22	17
Serine protease inhibitors	Serine protease inhibitors	22	16
Integrin domains	Integrin domains	22	12
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	21	2
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	21	15
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	21	11
SH3-domain	DBL homology domain (DH-domain)	21	14
PDZ domain-like	SH3-domain	20	10
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	20	10
GroES-like	NAD(P)-binding Rossmann-fold domains	20	6
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	19	7
Periplasmic binding protein-like I	Periplasmic binding protein-like II	19	5
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	19	11
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	19	2
L domain-like	Fibronectin type III	19	8
F-box domain	RNI-like	19	4
Thioredoxin-like	Thioredoxin-like	18	8
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	18	10
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	18	13
Cysteine-rich domain	PH domain-like	18	12
Integrin alpha N-terminal domain	Integrin domains	18	8
Snake toxin-like	Protein kinase-like (PK-like)	18	4
PH domain-like	EF-hand	18	13
Protein kinase-like (PK-like)	SAM/Pointed domain	18	10
MHC antigen-recognition domain	Immunoglobulin	17	3
ABC transporter transmembrane region	ABC transporter transmembrane region	17	4
(Trans)glycosidases	Glycosyl hydrolase domain	17	7
Cysteine-rich domain	Cysteine-rich domain	17	10
Cadherin-like	Concanavalin A-like lectins/glucanases	17	11
vWA-like	Integrin domains	17	12
FYVE/PHD zinc finger	Tudor/PWWP/MBT	17	10
BAR/IMD domain-like	GTPase activation domain, GAP	17	6
PH domain-like	ArfGap/RecO-like zinc finger	17	11
RING/U-box	RING/U-box	17	11
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	17	9
Voltage-gated potassium channels	E set domains	17	3
PH domain-like	PLC-like phosphodiesterases	16	11
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	16	7
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	16	6
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	16	5
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	16	2
EGF/Laminin	Complement control module/SCR domain	16	12
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	16	10
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	16	6
Ankyrin repeat	SOCS box-like	16	6
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	15	6
Ubiquitin-like	PDZ domain-like	15	11
Growth factor receptor domain	TSP-1 type 1 repeat	15	7
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	15	9
SH3-domain	GTPase activation domain, GAP	15	8
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	15	7
TrpR-like	Homeodomain-like	15	1
SAM/Pointed domain	"Winged helix" DNA-binding domain	15	6
SH2 domain	SH2 domain	15	12
Myosin rod fragments	P-loop containing nucleoside triphosphate hydrolases	15	13
Spermadhesin, CUB domain	EGF/Laminin	15	10
Growth factor receptor domain	Protein kinase-like (PK-like)	15	9
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	15	4
BAR/IMD domain-like	PH domain-like	15	8
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	14	8
dsRNA-binding domain-like	dsRNA-binding domain-like	14	10
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	14	7
Nucleotide cyclase	Nucleotide cyclase	14	5
GroEL equatorial domain-like	GroEL apical domain-like	14	3
Galactose-binding domain-like	Protein kinase-like (PK-like)	14	8
LDL receptor-like module	YWTD domain	14	14
LDL receptor-like module	Trypsin-like serine proteases	14	11
ENTH/VHS domain	GAT-like domain	14	3
Fibronectin type III	SAM/Pointed domain	14	7
Hormone receptor domain	Family A G protein-coupled receptor-like	14	4
Spermadhesin, CUB domain	Trypsin-like serine proteases	14	11
Ubiquitin-like	Protein kinase-like (PK-like)	14	4
EGF/Laminin	Trypsin-like serine proteases	14	8
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	14	9
FYVE/PHD zinc finger	Bromodomain	14	12
Myosin rod fragments	Myosin rod fragments	13	11
Galactose-binding domain-like	Fibronectin type III	13	8
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	13	10
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	13	7
Cadherin-like	EGF/Laminin	13	8
PGBD-like	Metalloproteases ("zincins"), catalytic domain	13	5
YWTD domain	EGF/Laminin	13	12
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	13	10
Spermadhesin, CUB domain	LDL receptor-like module	13	8
ARM repeat	Formin homology 2 domain (FH2 domain)	13	5
Kelch motif	Kelch motif	13	4
MFS general substrate transporter	Kazal-type serine protease inhibitors	13	3
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	13	8
p53-like transcription factors	E set domains	13	4
Cysteine-rich domain	C2 domain (Calcium/lipid-binding domain, CaLB)	13	7
Voltage-gated potassium channels	cAMP-binding domain-like	13	3
RING/U-box	TRAF domain-like	13	13
beta-beta-alpha zinc fingers	Homeodomain-like	13	9
Ankyrin repeat	PH domain-like	13	9
Spermadhesin, CUB domain	Complement control module/SCR domain	12	10
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	12	4
SRCR-like	Trypsin-like serine proteases	12	9
EF-hand	RING/U-box	12	6
L27 domain	PDZ domain-like	12	6
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	12	7
DEATH domain	P-loop containing nucleoside triphosphate hydrolases	12	7
TNF receptor-like	TNF receptor-like	12	9
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	12	4
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	12	5
Galactose-binding domain-like	Growth factor receptor domain	12	8
ARM repeat	PH domain-like	12	8
GroEL-intermediate domain like	GroEL apical domain-like	12	2
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	12	9
DEATH domain	Caspase-like	12	4
ARM repeat	WD40 repeat-like	12	11
Kazal-type serine protease inhibitors	EF-hand	12	5
L domain-like	Protein kinase-like (PK-like)	12	8
Immunoglobulin	TSP-1 type 1 repeat	12	7
"Winged helix" DNA-binding domain	PDZ domain-like	12	4
Concanavalin A-like lectins/glucanases	Growth factor receptor domain	12	10
Spectrin repeat	EF-hand	12	7
Calponin-homology domain, CH-domain	Spectrin repeat	12	9
Cysteine proteinases	EF-hand	11	3
PH domain-like	Oxysterol-binding protein-like	11	4
Chromo domain-like	Chromo domain-like	11	4
PH domain-like	WD40 repeat-like	11	6
PGBD-like	Hemopexin-like domain	11	3
YWTD domain	YWTD domain	11	9
PDZ domain-like	DBL homology domain (DH-domain)	11	4
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	11	5
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	11	7
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	11	5
SAM/Pointed domain	SAM/Pointed domain	11	4
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	11	10
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	11	3
POZ domain	POZ domain	11	9
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	11	7
LDL receptor-like module	EGF/Laminin	11	11
Plexin repeat	Immunoglobulin	11	3
GroEL equatorial domain-like	GroEL-intermediate domain like	11	1
EGF/Laminin	C-type lectin-like	11	10
cAMP-binding domain-like	cAMP-binding domain-like	11	7
Growth factor receptor domain	Fibronectin type III	11	7
Sema domain	Immunoglobulin	11	3
Voltage-gated potassium channels	Periplasmic binding protein-like II	11	4
L domain-like	Toll/Interleukin receptor TIR domain	11	8
ArfGap/RecO-like zinc finger	Ankyrin repeat	10	7
DEATH domain	DEATH domain	10	4
WWE domain	ADP-ribosylation	10	5
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	10	6
Calpain large subunit, middle domain (domain III)	EF-hand	10	2
Ubiquitin-like	Ubiquitin-like	10	9
Clc chloride channel	CBS-domain pair	10	4
RING/U-box	Cysteine proteinases	10	5
Galactose-binding domain-like	SAM/Pointed domain	10	5
Growth factor receptor domain	FnI-like domain	10	9
vWA-like	Integrin alpha N-terminal domain	10	7
Kringle-like	Trypsin-like serine proteases	10	10
WW domain	Hect, E3 ligase catalytic domain	10	8
Thiolase-like	Thiolase-like	10	4
vWA-like	EGF/Laminin	10	9
TPR-like	HCP-like	10	9
Immunoglobulin	Toll/Interleukin receptor TIR domain	10	7
Galactose-binding domain-like	Galactose-binding domain-like	10	7
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	10	5
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	10	3
Spectrin repeat	PH domain-like	10	9
Nucleic acid-binding proteins	Nucleic acid-binding proteins	10	10
Ankyrin repeat	SAM/Pointed domain	10	8
FnI-like domain	FnI-like domain	10	10
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	10	5
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	9	8
Bromodomain	Bromodomain	9	5
Kringle-like	Kringle-like	9	9
Cullin homology domain	"Winged helix" DNA-binding domain	9	4
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	9	4
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	9	3
Protease propeptides/inhibitors	Subtilisin-like	9	7
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	9	5
EF-hand	Cysteine-rich domain	9	5
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	9	4
Ricin B-like lectins	C-type lectin-like	9	6
F-box domain	WD40 repeat-like	9	4
ARM repeat	Ubiquitin-like	9	3
BEACH domain	WD40 repeat-like	9	6
Ankyrin repeat	DEATH domain	9	5
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	9	3
vWA-like	Integrin beta tail domain	9	7
BPTI-like	BPTI-like	9	8
Phospholipase D/nuclease	Phospholipase D/nuclease	9	5
PreATP-grasp domain	Rudiment single hybrid motif	9	4
Calponin-homology domain, CH-domain	EF-hand	9	4
PX domain	BAR/IMD domain-like	9	3
LDL receptor-like module	TSP-1 type 1 repeat	9	5
CoA-dependent acyltransferases	CoA-dependent acyltransferases	9	3
Ubiquitin-like	Ras GEF	9	8
PKD domain	PKD domain	9	6
Growth factor receptor domain	YWTD domain	9	8
Periplasmic binding protein-like I	Voltage-gated potassium channels	9	2
Doublecortin (DC)	Doublecortin (DC)	9	6
ARM repeat	Clathrin adaptor appendage domain	9	3
Ankyrin repeat	SH3-domain	9	6
Fibronectin type III	vWA-like	9	8
Protein kinase-like (PK-like)	KA1-like	8	3
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	8	5
Calponin-homology domain, CH-domain	PH domain-like	8	6
PH domain-like	"Winged helix" DNA-binding domain	8	3
L domain-like	Family A G protein-coupled receptor-like	8	8
SMAD MH1 domain	SMAD/FHA domain	8	3
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	8	5
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	8	3
PAZ domain	Ribonuclease H-like	8	4
TSP type-3 repeat	TSP type-3 repeat	8	5
EGF/Laminin	Galactose-binding domain-like	8	8
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	8	3
Acid proteases	Ribonuclease H-like	8	7
CalX-like	CalX-like	8	4
TB module/8-cys domain	TB module/8-cys domain	8	8
GLA-domain	Trypsin-like serine proteases	8	4
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	8	6
Ubiquitin-like	UBA-like	8	5
RING/U-box	UBA-like	8	5
Plexin repeat	vWA-like	8	6
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	8	3
Protein kinase-like (PK-like)	PDZ domain-like	8	4
LDL receptor-like module	Growth factor receptor domain	8	7
beta-sandwich domain of Sec23/24	vWA-like	8	5
L27 domain	SH3-domain	8	3
Plexin repeat	GTPase activation domain, GAP	8	5
Alpha-macroglobulin receptor domain	TIMP-like	8	3
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	8	5
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	8	5
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	8	5
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	8	5
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	8	8
PH domain-like	BEACH domain	8	5
CAD & PB1 domains	Protein kinase-like (PK-like)	8	4
TB module/8-cys domain	Growth factor receptor domain	8	8
Sec7 domain	PH domain-like	8	3
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	8	2
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	8	1
Subtilisin-like	Galactose-binding domain-like	8	7
L domain-like	Growth factor receptor domain	8	5
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	8	5
vWA-like	Helical domain of Sec23/24	8	5
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	8	6
L27 domain	P-loop containing nucleoside triphosphate hydrolases	8	3
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	8	6
Metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	8	5
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	8	3
SH2 domain	SOCS box-like	8	2
FnI-like domain	TSP-1 type 1 repeat	8	5
FYVE/PHD zinc finger	Clavaminate synthase-like	8	5
Actin depolymerizing proteins	Actin depolymerizing proteins	8	6
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	8	3
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	8	4
TNF receptor-like	DEATH domain	8	5
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	8	4
Terpenoid cyclases/Protein prenyltransferases	TIMP-like	8	3
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	8	8
SET domain	beta-beta-alpha zinc fingers	8	8
TB module/8-cys domain	EGF/Laminin	8	8
DEATH domain	Protein kinase-like (PK-like)	8	4
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	8	6
Ankyrin repeat	Protein kinase-like (PK-like)	8	5
CCCH zinc finger	CCCH zinc finger	8	6
Cysteine-rich domain	GTPase activation domain, GAP	8	5
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	3
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	8	7
Plexin repeat	E set domains	8	6
MFS general substrate transporter	MFS general substrate transporter	8	6
Acid proteases	DNA/RNA polymerases	8	5
SRCR-like	LDL receptor-like module	8	6
Thyroglobulin type-1 domain	EF-hand	8	4
BRCT domain	BRCT domain	8	7
Anaphylotoxins (complement system)	Terpenoid cyclases/Protein prenyltransferases	8	3
Cullin repeat-like	Cullin homology domain	8	3
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	7	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	7	3
Anaphylotoxins (complement system)	Alpha-macroglobulin receptor domain	7	2
PH domain-like	Ypt/Rab-GAP domain of gyp1p	7	4
ARM repeat	Subdomain of clathrin and coatomer appendage domain	7	2
Snake toxin-like	Snake toxin-like	7	1
Cap-Gly domain	Cap-Gly domain	7	5
ADC-like	P-loop containing nucleoside triphosphate hydrolases	7	3
Immunoglobulin	(Phosphotyrosine protein) phosphatases II	7	3
SH2 domain	(Phosphotyrosine protein) phosphatases II	7	4
Complement control module/SCR domain	Trypsin-like serine proteases	7	5
Flavoproteins	Riboflavin synthase domain-like	7	5
Second domain of FERM	Protein kinase-like (PK-like)	7	3
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	7	2
SH3-domain	PX domain	7	5
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	7	6
ClpP/crotonase	ClpP/crotonase	7	5
Tudor/PWWP/MBT	SAM/Pointed domain	7	5
Calponin-homology domain, CH-domain	SH3-domain	7	5
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	7	2
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	7	2
FKBP-like	TPR-like	7	3
FnI-like domain	EGF/Laminin	7	5
Sema domain	GTPase activation domain, GAP	7	4
EGF/Laminin	Integrin beta tail domain	7	6
PDZ domain-like	Glucocorticoid receptor-like (DNA-binding domain)	7	4
E set domains	Cysteine proteinases	7	2
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	7	2
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	7	3
Kringle-like	C-type lectin-like	7	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	7	3
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	7	4
Translation proteins	EF-G C-terminal domain-like	7	4
GLA-domain	EGF/Laminin	7	3
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	7	3
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	7	6
Spectrin repeat	DBL homology domain (DH-domain)	7	6
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	7	5
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	7	5
Cupredoxins	Cupredoxins	7	5
FAS1 domain	FAS1 domain	7	5
Sema domain	E set domains	7	5
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	7	4
Integrin domains	Integrin beta tail domain	7	5
E set domains	GTPase activation domain, GAP	7	5
P-loop containing nucleoside triphosphate hydrolases	RNI-like	7	4
Cullin repeat-like	"Winged helix" DNA-binding domain	7	2
SH3-domain	EF-hand	7	7
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	7	3
PH domain-like	Ras GEF	7	5
Growth factor receptor domain	SAM/Pointed domain	7	4
Anaphylotoxins (complement system)	TIMP-like	7	2
Protease propeptides/inhibitors	Galactose-binding domain-like	7	6
Protease propeptides/inhibitors	Zn-dependent exopeptidases	7	1
Elafin-like	Elafin-like	7	3
ARM repeat	Concanavalin A-like lectins/glucanases	7	6
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	7	6
Plexin repeat	Integrin beta tail domain	7	5
EGF/Laminin	Family A G protein-coupled receptor-like	7	6
E set domains	Terpenoid cyclases/Protein prenyltransferases	7	4
BAR/IMD domain-like	Ankyrin repeat	6	4
Ribonuclease H-like	Ribonuclease H-like	6	5
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	6	4
SH2 domain	GTPase activation domain, GAP	6	4
PH domain-like	Moesin tail domain	6	2
Galactose-binding domain-like	Concanavalin A-like lectins/glucanases	6	5
C-type lectin-like	Complement control module/SCR domain	6	6
Protein kinase-like (PK-like)	Nucleotide cyclase	6	4
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	6	3
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	6	4
Ubiquitin-like	SH2 domain	6	4
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	6	1
DEATH domain	Immunoglobulin	6	3
SAM/Pointed domain	Bet v1-like	6	2
GTPase activation domain, GAP	Bet v1-like	6	2
Ricin B-like lectins	Kringle-like	6	3
GroES-like	GroES-like	6	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	6	2
Rudiment single hybrid motif	Single hybrid motif	6	3
Cysteine proteinases	DUSP-like	6	5
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	6	4
Kazal-type serine protease inhibitors	Thyroglobulin type-1 domain	6	2
Cysteine proteinases	Transglutaminase, two C-terminal domains	6	2
Second domain of FERM	PDZ domain-like	6	5
Translation proteins	Ribosomal protein S5 domain 2-like	6	3
DEATH domain	RNI-like	6	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	6	3
Ubiquitin-like	Moesin tail domain	6	2
PurM N-terminal domain-like	PurM C-terminal domain-like	6	3
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	6	3
SH3-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	6	6
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	6	5
Cystatin/monellin	Cystatin/monellin	6	3
SAM/Pointed domain	GTPase activation domain, GAP	6	2
PA domain	Transferrin receptor-like dimerisation domain	6	1
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	6	1
PA domain	RING/U-box	6	2
E set domains	Alpha-macroglobulin receptor domain	6	3
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	6	2
Hermes dimerisation domain	Ribonuclease H-like	6	5
PR-1-like	Crisp domain-like	6	1
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	6	4
"Winged helix" DNA-binding domain	SMAD/FHA domain	6	2
Plexin repeat	Integrin domains	6	4
RING/U-box	WD40 repeat-like	6	6
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	6	4
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	6	3
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	6	5
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	6	4
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	6	4
Second domain of FERM	Moesin tail domain	6	2
PH domain-like	FYVE/PHD zinc finger	6	5
GAF domain-like	HD-domain/PDEase-like	6	4
FYVE/PHD zinc finger	SET domain	6	5
Kazal-type serine protease inhibitors	EGF/Laminin	6	3
Zn-finger domain of Sec23/24	vWA-like	6	3
Immunoglobulin	C-type lectin-like	6	5
C2 domain (Calcium/lipid-binding domain, CaLB)	FabD/lysophospholipase-like	6	2
Integrin domains	EGF/Laminin	6	5
Ubiquitin-like	Cysteine-rich domain	6	3
Plexin repeat	EGF/Laminin	6	5
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	6	5
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	6	3
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	6	1
EF-hand	Mitochondrial carrier	6	2
PA domain	Zn-dependent exopeptidases	6	1
PreATP-grasp domain	Single hybrid motif	6	3
Concanavalin A-like lectins/glucanases	FnI-like domain	6	4
B-box zinc-binding domain	Fibronectin type III	6	4
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	6	4
EF-hand	SH2 domain	6	5
PX domain	Protein kinase-like (PK-like)	6	4
Spectrin repeat	SH3-domain	6	5
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	6	3
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	6	5
TRAF domain-like	TRAF domain-like	6	6
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	6	3
Metalloproteases ("zincins"), catalytic domain	ARM repeat	6	3
CRAL/TRIO domain	DBL homology domain (DH-domain)	6	5
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	5	5
Calponin-homology domain, CH-domain	SH2 domain	5	3
SNARE fusion complex	SNARE fusion complex	5	2
MIR domain	IP3 receptor type 1 binding core, domain 2	5	3
Trypsin-like serine proteases	PDZ domain-like	5	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	5	5
RING/U-box	NHL repeat	5	5
Ypt/Rab-GAP domain of gyp1p	EF-hand	5	1
FYVE/PHD zinc finger	RING/U-box	5	5
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	5	2
GAF domain-like	GAF domain-like	5	3
"Winged helix" DNA-binding domain	Ubiquitin-like	5	5
Ubiquitin-like	Cysteine proteinases	5	4
PH domain-like	SAM/Pointed domain	5	3
Concanavalin A-like lectins/glucanases	LDL receptor-like module	5	4
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	5	2
SAM/Pointed domain	PDZ domain-like	5	4
FKBP-like	FKBP-like	5	2
Somatomedin B domain	Somatomedin B domain	5	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	5	3
Alkaline phosphatase-like	His-Me finger endonucleases	5	2
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	5	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	5	3
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	5	4
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	5	3
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	5	3
Regulator of G-protein signaling, RGS	PH domain-like	5	4
E set domains	Transglutaminase, two C-terminal domains	5	1
TSP-1 type 1 repeat	DEATH domain	5	2
PLC-like phosphodiesterases	SH2 domain	5	5
P-loop containing nucleoside triphosphate hydrolases	POZ domain	5	3
Ribonuclease H-like	RNA-binding domain, RBD	5	4
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	5	2
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	5	4
WW domain	RING/U-box	5	3
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	5	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	5	4
Retrovirus capsid dimerization domain-like	Acid proteases	5	4
SEA domain	LDL receptor-like module	5	4
Spermadhesin, CUB domain	Galactose-binding domain-like	5	2
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	5	3
Periplasmic binding protein-like I	Nucleotide cyclase	5	3
E set domains	Ankyrin repeat	5	3
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	5	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	5	2
P-loop containing nucleoside triphosphate hydrolases	TPR-like	5	4
EF-hand	P-loop containing nucleoside triphosphate hydrolases	5	3
beta-beta-alpha zinc fingers	Ribonuclease H-like	5	4
Cysteine proteinases	UBA-like	5	2
CRAL/TRIO domain	PH domain-like	5	4
EF-hand	NAD kinase/diacylglycerol kinase-like	5	4
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	5	2
CCCH zinc finger	RING/U-box	5	4
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	5	3
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	5	4
p53-like transcription factors	SH2 domain	5	3
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	5	4
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	5	4
FYVE/PHD zinc finger	B-box zinc-binding domain	5	3
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	5	3
DBL homology domain (DH-domain)	Ras GEF	5	4
MAST3 pre-PK domain-like	PDZ domain-like	5	2
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	5	3
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	5	3
Transcription factor STAT-4 N-domain	p53-like transcription factors	5	3
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	5	2
SMAD/FHA domain	PDZ domain-like	5	3
Carboxypeptidase regulatory domain-like	NHL repeat	5	5
B-box zinc-binding domain	NHL repeat	5	4
Phosphofructokinase	Phosphofructokinase	5	2
EGF/Laminin	TSP type-3 repeat	5	3
Single hybrid motif	CoA-dependent acyltransferases	5	5
Ubiquitin-like	PX domain	5	2
Concanavalin A-like lectins/glucanases	(Phosphotyrosine protein) phosphatases II	5	1
WW domain	EF-hand	5	3
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	5	3
SEA domain	Trypsin-like serine proteases	5	4
SEA domain	Spermadhesin, CUB domain	5	4
beta-beta-alpha zinc fingers	Hermes dimerisation domain	5	4
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	5	1
Second domain of FERM	Second domain of FERM	5	2
Transcription factor STAT-4 N-domain	SH2 domain	5	3
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	5	3
EGF/Laminin	TIMP-like	5	5
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	5	2
FYVE/PHD zinc finger	PDZ domain-like	5	3
Concanavalin A-like lectins/glucanases	Family A G protein-coupled receptor-like	5	3
DBL homology domain (DH-domain)	SH2 domain	5	3
Ras GEF	EF-hand	5	2
CRAL/TRIO domain	Spectrin repeat	5	4
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	5	3
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	5	4
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	5	2
Folate-binding domain	Aminomethyltransferase beta-barrel domain	5	3
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	5	5
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	5	3
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	5	4
Kazal-type serine protease inhibitors	Immunoglobulin	5	4
EF-hand	C-terminal domain of PLC-beta	5	3
Macro domain-like	Macro domain-like	5	3
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	2
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	5	3
Clavaminate synthase-like	Tudor/PWWP/MBT	5	2
Sec7 domain	ARM repeat	5	4
TPR-like	RING/U-box	5	4
ARM repeat	Cysteine proteinases	5	3
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	5	3
Spectrin repeat	RING/U-box	5	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	5	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	5	4
Growth factor receptor domain	Thyroglobulin type-1 domain	5	3
PUA domain-like	RING/U-box	5	4
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	5	3
Retrovirus capsid dimerization domain-like	Retrovirus zinc finger-like domains	5	4
Spectrin repeat	WW domain	5	3
C-type lectin-like	Growth factor receptor domain	5	5
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	5	3
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	5	3
Serum albumin-like	Serum albumin-like	5	2
PLC-like phosphodiesterases	SH3-domain	5	5
ADC-like	Cdc48 domain 2-like	5	2
(Trans)glycosidases	Chitinase insertion domain	5	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	5	3
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	5	3
Serine protease inhibitors	FnI-like domain	5	5
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	4	3
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	4	2
Translation proteins SH3-like domain	Nucleic acid-binding proteins	4	2
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	4	4
t-snare proteins	SNARE fusion complex	4	2
cAMP-binding domain-like	Ras GEF	4	4
Spectrin repeat	Plakin repeat	4	4
PsbU/PolX domain-like	Nucleotidyltransferase	4	3
Ankyrin repeat	POZ domain	4	4
DBL homology domain (DH-domain)	"Winged helix" DNA-binding domain	4	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	4	2
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	4	3
beta-beta-alpha zinc fingers	Leucine zipper domain	4	1
PDZ domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	4	2
SH2 domain	VPS9 domain	4	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	4	2
vWA-like	Growth factor receptor domain	4	4
Concanavalin A-like lectins/glucanases	Fibrinogen C-terminal domain-like	4	4
RNA-binding domain, RBD	NTF2-like	4	2
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	4	4
HCP-like	HCP-like	4	3
vWA-like	Chicken cartilage matrix protein	4	3
Intermediate filament protein, coiled coil region	Prefoldin	4	3
Protease propeptides/inhibitors	Growth factor receptor domain	4	3
B-box zinc-binding domain	E set domains	4	3
Transcription factor STAT-4 N-domain	STAT	4	2
Sema domain	TSP-1 type 1 repeat	4	2
Actin depolymerizing proteins	VHP, Villin headpiece domain	4	3
Fibronectin type III	Fibrinogen C-terminal domain-like	4	4
cAMP-binding domain-like	Ubiquitin-like	4	4
STAT	SH2 domain	4	2
PH domain-like	C-terminal domain of PLC-beta	4	2
ENTH/VHS domain	Clathrin adaptor appendage domain	4	1
RING/U-box	PDZ domain-like	4	2
Cysteine-rich domain	Tricorn protease domain 2	4	1
KRAB domain (Kruppel-associated box)	Homeodomain-like	4	2
Prefoldin	WD40 repeat-like	4	2
Protein kinase-like (PK-like)	NTF2-like	4	1
MIT domain	Cysteine proteinases	4	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	4	2
ARM repeat	PX domain	4	2
L27 domain	L27 domain	4	2
SH3-domain	ARM repeat	4	1
WW domain	PDZ domain-like	4	4
Ubiquitin-like	SMAD/FHA domain	4	2
gamma-Crystallin-like	Ricin B-like lectins	4	3
Subtilisin-like	Growth factor receptor domain	4	3
lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	4	3
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	4	3
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	4	3
ARM repeat	BEACH domain	4	3
RING/U-box	KRAB domain (Kruppel-associated box)	4	4
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	4	3
TPR-like	SH3-domain	4	4
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	4	2
Tudor/PWWP/MBT	SET domain	4	3
Chitinase insertion domain	Invertebrate chitin-binding proteins	4	1
TPR-like	"Winged helix" DNA-binding domain	4	2
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	4	2
Surp module (SWAP domain)	Surp module (SWAP domain)	4	3
GTF2I-like repeat	GTF2I-like repeat	4	3
EGF/Laminin	Fibronectin type III	4	4
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	4	4
E set domains	P-loop containing nucleoside triphosphate hydrolases	4	3
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	4	2
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	4	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	4	2
Retrovirus zinc finger-like domains	Acid proteases	4	3
Nucleotidylyl transferase	P-loop containing nucleoside triphosphate hydrolases	4	3
ClpS-like	"Winged helix" DNA-binding domain	4	1
FKBP-like	EF-hand	4	3
Concanavalin A-like lectins/glucanases	WD40 repeat-like	4	3
PDZ domain-like	Regulator of G-protein signaling, RGS	4	3
RNA-binding domain, RBD	Ran binding protein zinc finger-like	4	4
FF domain	FF domain	4	4
Tudor/PWWP/MBT	Staphylococcal nuclease	4	3
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	4	1
Cysteine-rich domain	DBL homology domain (DH-domain)	4	3
Fibrinogen coiled-coil and central regions	Fibrinogen C-terminal domain-like	4	3
Ubiquitin-like	Ankyrin repeat	4	2
SH2 domain	Cysteine-rich domain	4	3
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	4	1
B-box zinc-binding domain	KRAB domain (Kruppel-associated box)	4	4
MFS general substrate transporter	Pentapeptide repeat-like	4	3
HMG-box	HMG-box	4	2
Growth factor receptor domain	Immunoglobulin	4	3
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	4	3
Fibronectin type III	YWTD domain	4	3
MIR domain	MIR domain	4	2
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	4	2
Tropomyosin	Myosin rod fragments	4	3
Kazal-type serine protease inhibitors	Trypsin-like serine proteases	4	4
HLH, helix-loop-helix DNA-binding domain	Nuclear receptor coactivator interlocking domain	4	1
ARID-like	ARM repeat	4	2
P-loop containing nucleoside triphosphate hydrolases	ArfGap/RecO-like zinc finger	4	2
FAD-linked reductases, C-terminal domain	Folate-binding domain	4	2
SH3-domain	Fibronectin type III	4	3
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	4	1
Nucleotide cyclase	P-loop containing nucleoside triphosphate hydrolases	4	2
(Trans)glycosidases	Invertebrate chitin-binding proteins	4	1
Second domain of FERM	SH2 domain	4	2
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	4	4
Ypt/Rab-GAP domain of gyp1p	RUN domain-like	4	2
Metalloproteases ("zincins"), catalytic domain	Concanavalin A-like lectins/glucanases	4	4
RNI-like	RNI-like	4	4
PYP-like sensor domain (PAS domain)	Nuclear receptor coactivator interlocking domain	4	1
RCC1/BLIP-II	POZ domain	4	2
Periplasmic binding protein-like II	Periplasmic binding protein-like II	4	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	4	4
Retrovirus capsid dimerization domain-like	Ribonuclease H-like	4	3
Galactose-binding domain-like	(Trans)glycosidases	4	3
Plexin repeat	TSP-1 type 1 repeat	4	2
Protein kinase-like (PK-like)	Polo-box domain	4	3
KRAB domain (Kruppel-associated box)	KRAB domain (Kruppel-associated box)	4	4
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	4	3
PH domain-like	Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	4	2
Somatomedin B domain	His-Me finger endonucleases	4	1
TAFH domain-like	HIT/MYND zinc finger-like	4	1
WW domain	PH domain-like	4	3
STAT	p53-like transcription factors	4	2
Myosin rod fragments	Lamin A/C globular tail domain	4	3
WW domain	FF domain	4	4
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	4	3
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	4	3
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	4	4
Spermadhesin, CUB domain	C-type lectin-like	4	3
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	P-loop containing nucleoside triphosphate hydrolases	4	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	4	3
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	4	4
Trypsin-like serine proteases	Trypsin-like serine proteases	4	4
Ankyrin repeat	TPR-like	4	4
Ras GEF	Cysteine-rich domain	4	1
Myosin rod fragments	Intermediate filament protein, coiled coil region	4	3
Protein kinase-like (PK-like)	Tricorn protease domain 2	4	1
Immunoglobulin	Kringle-like	4	4
Calponin-homology domain, CH-domain	GAS2 domain-like	4	3
FAD/NAD(P)-binding domain	Folate-binding domain	4	2
Galactose mutarotase-like	(Trans)glycosidases	4	3
POZ domain	Galactose oxidase, central domain	4	3
ArfGap/RecO-like zinc finger	SH3-domain	4	2
Retrovirus zinc finger-like domains	Ribonuclease H-like	4	3
P-loop containing nucleoside triphosphate hydrolases	Prefoldin	4	2
Actin-crosslinking proteins	Actin-crosslinking proteins	4	2
ARM repeat	Hect, E3 ligase catalytic domain	4	3
GAT-like domain	Clathrin adaptor appendage domain	4	1
Frizzled cysteine-rich domain	TIMP-like	4	2
SMAD/FHA domain	PH domain-like	4	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	4	3
Regulator of G-protein signaling, RGS	PX domain	4	2
Somatomedin B domain	Alkaline phosphatase-like	4	1
Kringle-like	Protein kinase-like (PK-like)	4	4
SEA domain	SEA domain	4	2
vWA-like	Concanavalin A-like lectins/glucanases	4	3
C2 domain (Calcium/lipid-binding domain, CaLB)	PX domain	4	2
CRAL/TRIO domain	SH3-domain	4	3
PH domain-like	Tricorn protease domain 2	4	1
Concanavalin A-like lectins/glucanases	P-loop containing nucleoside triphosphate hydrolases	4	4
Growth factor receptor domain	Spermadhesin, CUB domain	4	3
Galactose mutarotase-like	Glycosyl hydrolase domain	4	3
FAS1 domain	EGF/Laminin	3	3
Concanavalin A-like lectins/glucanases	EF-hand	3	3
GTPase activation domain, GAP	CRAL/TRIO domain	3	3
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	3	3
Ubiquitin-like	FAT domain of focal adhesion kinase	3	1
Thioredoxin-like	Ubiquitin-like	3	3
RING/U-box	SH3-domain	3	2
GST C-terminal domain-like	Nucleotidylyl transferase	3	3
PreATP-grasp domain	PurM N-terminal domain-like	3	1
Spermadhesin, CUB domain	LCCL domain	3	1
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	3	1
Homeodomain-like	RING/U-box	3	2
Spectrin repeat	Protein kinase-like (PK-like)	3	2
L domain-like	Concanavalin A-like lectins/glucanases	3	2
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	3	1
P-loop containing nucleoside triphosphate hydrolases	BRK domain-like	3	2
LCCL domain	vWA-like	3	2
MgtE membrane domain-like	MgtE membrane domain-like	3	1
SAM/Pointed domain	ADP-ribosylation	3	3
UBA-like	P-loop containing nucleoside triphosphate hydrolases	3	3
Glutathione synthetase ATP-binding domain-like	Formyltransferase	3	1
Elafin-like	Fibronectin type III	3	1
EGF/Laminin	EF-hand	3	1
CCHHC domain	CCHHC domain	3	3
PurM C-terminal domain-like	Formyltransferase	3	1
Rudiment single hybrid motif	PurM N-terminal domain-like	3	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	3	2
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Polo-box domain	Polo-box domain	3	3
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	3	2
FAD/NAD(P)-binding domain	Glucocorticoid receptor-like (DNA-binding domain)	3	2
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	3	3
WD40 repeat-like	EF-hand	3	3
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	3	3
TPR-like	SET domain	3	2
PLP-binding barrel	Alanine racemase C-terminal domain-like	3	2
Bromodomain	Tudor/PWWP/MBT	3	3
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	3	2
HMA, heavy metal-associated domain	HAD-like	3	3
TPR-like	Chaperone J-domain	3	2
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	3	1
L domain-like	EGF/Laminin	3	2
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	3	2
Thioredoxin-like	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	3	1
Cystine-knot cytokines	Heparin-binding domain from vascular endothelial growth factor	3	1
Protein kinase-like (PK-like)	WD40 repeat-like	3	3
Rudiment single hybrid motif	Formyltransferase	3	1
Plakin repeat	Plakin repeat	3	3
CAD & PB1 domains	UBA-like	3	2
UBA-like	Protein kinase-like (PK-like)	3	3
Actin depolymerizing proteins	SH3-domain	3	1
"Winged helix" DNA-binding domain	GTPase activation domain, GAP	3	1
Dimerization cofactor of HNF-1 alpha	lambda repressor-like DNA-binding domains	3	2
gamma-Crystallin-like	gamma-Crystallin-like	3	2
Immunoglobulin	EGF/Laminin	3	3
Concanavalin A-like lectins/glucanases	TRAF domain-like	3	3
Colipase-like	Colipase-like	3	1
PH domain-like	Phospholipase D/nuclease	3	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	3	2
Growth factor receptor domain	Kazal-type serine protease inhibitors	3	3
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	3	1
HR1 repeat	Protein kinase-like (PK-like)	3	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	3	3
SAP domain	RNA-binding domain, RBD	3	1
Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	3	2
Hairpin loop containing domain-like	Trypsin-like serine proteases	3	3
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
TPR-like	CCCH zinc finger	3	3
BRCT domain	Nucleotidyltransferase	3	2
Formate/glycerate dehydrogenase catalytic domain-like	DHS-like NAD/FAD-binding domain	3	1
SH3-domain	SAM/Pointed domain	3	2
PX domain	Phospholipase D/nuclease	3	2
CAD & PB1 domains	PDZ domain-like	3	2
PKD domain	Lipase/lipooxygenase domain (PLAT/LH2 domain)	3	3
Cupredoxins	Pentein	3	1
DNA-binding protein LAG-1 (CSL)	E set domains	3	1
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	3	2
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	3	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	3	3
Sec63 N-terminal domain-like	E set domains	3	3
Rudiment single hybrid motif	PurM C-terminal domain-like	3	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	3	2
BRCT domain	DNA polymerase beta, N-terminal domain-like	3	2
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	3	2
C-type lectin-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	3	3
PHM/PNGase F	PHM/PNGase F	3	2
LDL receptor-like module	Complement control module/SCR domain	3	2
TATA-box binding protein-like	TATA-box binding protein-like	3	2
B-box zinc-binding domain	Bromodomain	3	2
RING/U-box	beta-beta-alpha zinc fingers	3	3
Serine protease inhibitors	AbfB domain	3	2
SH2 domain	DNase I-like	3	1
PUA domain-like	Nucleotidylyl transferase	3	2
Growth factor receptor domain	Family A G protein-coupled receptor-like	3	3
Histone-fold	DBL homology domain (DH-domain)	3	2
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	3	2
Ankyrin repeat	HIT/MYND zinc finger-like	3	2
GFP-like	Growth factor receptor domain	3	2
ARM repeat	"Winged helix" DNA-binding domain	3	2
FnI-like domain	TSP type-3 repeat	3	1
Concanavalin A-like lectins/glucanases	TSP-1 type 1 repeat	3	1
Second domain of FERM	FAT domain of focal adhesion kinase	3	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	3	3
RING/U-box	Fibronectin type III	3	2
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	3	1
L domain-like	Outer arm dynein light chain 1	3	3
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	3	1
TSP-1 type 1 repeat	Complement control module/SCR domain	3	2
G protein-binding domain	PH domain-like	3	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	3	3
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	3	2
Histone-fold	Ras GEF	3	2
Plexin repeat	Plexin repeat	3	2
Smc hinge domain	Tropomyosin	3	3
TAFH domain-like	Histone-fold	3	1
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Ankyrin repeat	Fibronectin type III	3	2
PurM N-terminal domain-like	Formyltransferase	3	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	3	3
TSP-1 type 1 repeat	EGF/Laminin	3	1
(Trans)glycosidases	(Trans)glycosidases	3	3
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	3	2
"Winged helix" DNA-binding domain	FYVE/PHD zinc finger	3	3
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	3	1
MIR domain	EF-hand	3	3
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	3	2
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	3	1
NAD(P)-binding Rossmann-fold domains	SCP-like	3	2
Spectrin repeat	Immunoglobulin	3	2
NAD kinase/diacylglycerol kinase-like	Ankyrin repeat	3	1
RNI-like	ARM repeat	3	1
CCHHC domain	SAM/Pointed domain	3	2
EGF/Laminin	Heme-dependent peroxidases	3	3
UBA-like	SH3-domain	3	3
Immunoglobulin	GFP-like	3	2
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	3	2
Concanavalin A-like lectins/glucanases	BEACH domain	3	2
PH domain-like	NAD kinase/diacylglycerol kinase-like	3	3
RUN domain-like	FYVE/PHD zinc finger	3	1
Dimerization cofactor of HNF-1 alpha	Homeodomain-like	3	2
"Winged helix" DNA-binding domain	Ras GEF	3	3
L domain-like	P-loop containing nucleoside triphosphate hydrolases	3	3
Regulator of G-protein signaling, RGS	Ubiquitin-like	3	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	3	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	3	3
CAD & PB1 domains	RING/U-box	3	2
Thioredoxin-like	FAD/NAD(P)-binding domain	3	1
Thioesterase/thiol ester dehydrase-isomerase	Bet v1-like	3	1
Apolipoprotein A-I	Apolipoprotein A-I	3	2
UBA-like	UBA-like	3	3
Ubiquitin-like	SH3-domain	3	2
FYVE/PHD zinc finger	Chromo domain-like	3	1
ENTH/VHS domain	SH3-domain	3	2
RNA-binding domain, RBD	SPOC domain-like	3	3
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	3	2
PH domain-like	Tropomyosin	3	2
Surp module (SWAP domain)	ENTH/VHS domain	3	2
LDL receptor-like module	BPTI-like	3	2
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	3	3
SH3-domain	CAD & PB1 domains	3	3
YVTN repeat-like/Quinoprotein amine dehydrogenase	WD40 repeat-like	3	3
MIR domain	Concanavalin A-like lectins/glucanases	3	3
Voltage-gated potassium channels	Small-conductance potassium channel	3	2
Retrovirus zinc finger-like domains	DNA/RNA polymerases	3	2
Rap/Ran-GAP	PDZ domain-like	3	2
PreATP-grasp domain	PurM C-terminal domain-like	3	1
TSP-1 type 1 repeat	TSP type-3 repeat	3	1
Tudor/PWWP/MBT	CCHHC domain	3	2
Peptidylarginine deiminase Pad4, middle domain	Pentein	3	1
L domain-like	WD40 repeat-like	3	3
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	3	2
F-box domain	Galactose-binding domain-like	3	1
EF-hand	Riboflavin synthase domain-like	3	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	3	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	3	1
SH2 domain	Ras GEF	3	2
USP8 N-terminal domain-like	JAB1/MPN domain	3	1
P-loop containing nucleoside triphosphate hydrolases	SOCS box-like	3	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	3	1
WD40 repeat-like	FYVE/PHD zinc finger	3	3
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	3	1
Ankyrin repeat	ADP-ribosylation	3	3
Translational machinery components	L30e-like	3	2
Eukaryotic type KH-domain (KH-domain type I)	RING/U-box	3	2
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	3
Frizzled cysteine-rich domain	Zn-dependent exopeptidases	3	2
TGS-like	ThrRS/AlaRS common domain	3	3
PKD domain	C-type lectin-like	3	3
Cadherin-like	Family A G protein-coupled receptor-like	3	2
Spermadhesin, CUB domain	TIMP-like	3	3
Metalloproteases ("zincins"), catalytic domain	TRAF domain-like	3	3
Macro domain-like	ADP-ribosylation	3	2
PreATP-grasp domain	Formyltransferase	3	1
Ubiquitin-like	GTPase activation domain, GAP	3	2
BRCT domain	PsbU/PolX domain-like	3	2
RNI-like	L domain-like	3	3
SNARE-like	SNARE fusion complex	3	2
LCCL domain	Galactose-binding domain-like	3	1
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	3	2
TPR-like	PUA domain-like	3	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	3	1
SWIB/MDM2 domain	Ran binding protein zinc finger-like	3	2
BAR/IMD domain-like	Cysteine-rich domain	3	1
PX domain	PH domain-like	3	2
DBL homology domain (DH-domain)	WD40 repeat-like	3	1
Immunoglobulin	Hormone receptor domain	3	2
PAH2 domain	PAH2 domain	3	3
E set domains	NHL repeat	3	2
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	3	1
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	3	2
Immunoglobulin	Complement control module/SCR domain	3	3
Retrovirus capsid dimerization domain-like	DNA/RNA polymerases	3	2
RNA-binding domain, RBD	SET domain	3	2
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	3	3
WWE domain	RING/U-box	3	3
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	3	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	3	1
beta-beta-alpha zinc fingers	FYVE/PHD zinc finger	3	1
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	3	2
RING/U-box	E set domains	3	3
CRAL/TRIO domain	Protein kinase-like (PK-like)	3	2
Immunoglobulin	Caspase-like	3	2
Histone-fold	PH domain-like	3	2
Concanavalin A-like lectins/glucanases	PH domain-like	3	2
Protein kinase-like (PK-like)	G protein-binding domain	3	2
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	3	1
G protein-binding domain	Cysteine-rich domain	3	2
RNA-binding domain, RBD	PABC (PABP) domain	3	2
Oligoxyloglucan reducing end-specific cellobiohydrolase	PKD domain	3	2
p53-like transcription factors	p53 tetramerization domain	3	3
Cupredoxins	Peptidylarginine deiminase Pad4, middle domain	3	1
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	3	2
Immunoglobulin	BPTI-like	3	2
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	3	2
L domain-like	Calponin-homology domain, CH-domain	3	1
Ankyrin repeat	RING/U-box	3	2
Protein kinase-like (PK-like)	RCC1/BLIP-II	3	2
Mib/herc2 domain-like	Ankyrin repeat	3	2
WD40 repeat-like	Bromodomain	3	2
Alkaline phosphatase-like	Alkaline phosphatase-like	3	2
Growth factor receptor domain	Mannose 6-phosphate receptor domain	3	2
vWA-like	SPOC domain-like	3	2
Retrovirus capsid dimerization domain-like	beta-beta-alpha zinc fingers	3	2
DBL homology domain (DH-domain)	Protein kinase-like (PK-like)	3	2
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	3	3
Clathrin heavy-chain terminal domain	ARM repeat	3	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	3	1
Restriction endonuclease-like	RuvA domain 2-like	3	3
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	3	2
Hairpin loop containing domain-like	Kringle-like	3	3
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	3	2
PH domain-like	FAT domain of focal adhesion kinase	3	1
Homocysteine S-methyltransferase	Methionine synthase domain	2	2
Ankyrin repeat	Cap-Gly domain	2	2
Ribosomal protein L25-like	Class II aaRS ABD-related	2	2
ARM repeat	WWE domain	2	1
FYVE/PHD zinc finger	RNI-like	2	2
PheT/TilS domain	Putative DNA-binding domain	2	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	2	1
ARM repeat	Rap/Ran-GAP	2	2
Ubiquitin-like	XPC-binding domain	2	2
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	2	2
Kringle-like	EGF/Laminin	2	2
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	2	2
L domain-like	C-type lectin-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Cysteine-rich domain	2	2
SEA domain	Concanavalin A-like lectins/glucanases	2	2
P-loop containing nucleoside triphosphate hydrolases	FF domain	2	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	2	1
SAP domain	DEK C-terminal domain	2	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	2	2
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	2	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	2	2
N-terminal domain of cbl (N-cbl)	UBA-like	2	1
S-adenosyl-L-methionine-dependent methyltransferases	NAD(P)-binding Rossmann-fold domains	2	2
Nucleotide cyclase	TPR-like	2	1
Ubiquitin-like	Cap-Gly domain	2	2
DBL homology domain (DH-domain)	GTPase activation domain, GAP	2	2
UBC-like	Endosomal sorting complex assembly domain	2	1
Amine oxidase N-terminal region	Amine oxidase N-terminal region	2	2
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	2	1
Nucleotidylyl transferase	Class II aaRS ABD-related	2	2
TPR-like	RNA-binding domain, RBD	2	2
Serine protease inhibitors	EGF/Laminin	2	2
DUSP-like	Ubiquitin-like	2	2
Galactose-binding domain-like	TIMP-like	2	2
Trimeric LpxA-like enzymes	ARM repeat	2	1
N-terminal domain of cbl (N-cbl)	EF-hand	2	1
PH domain-like	RING/U-box	2	1
EGF/Laminin	Notch domain	2	2
L domain-like	Tricorn protease domain 2	2	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	2	1
HSP20-like chaperones	Riboflavin synthase domain-like	2	2
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	2	2
RuvA domain 2-like	RuvA domain 2-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	2	1
Metalloproteases ("zincins"), catalytic domain	Immunoglobulin	2	1
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	2	2
Protein kinase-like (PK-like)	L27 domain	2	1
Kix domain of CBP (creb binding protein)	Bromodomain	2	2
PABC (PABP) domain	Hect, E3 ligase catalytic domain	2	2
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	2	2
Six-hairpin glycosidases	Six-hairpin glycosidases	2	1
SH2 domain	UBA-like	2	1
ENTH/VHS domain	RNA-binding domain, RBD	2	2
Notch domain	Ankyrin repeat	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	2	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	2	2
PDZ domain-like	Ras GEF	2	2
Calpain large subunit, middle domain (domain III)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
HR1 repeat	PDZ domain-like	2	2
N-terminal domain of cbl (N-cbl)	SH2 domain	2	1
RING/U-box	DUSP-like	2	1
Midkine	Midkine	2	2
Calponin-homology domain, CH-domain	PRC-barrel domain	2	1
Kix domain of CBP (creb binding protein)	RING/U-box	2	2
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	2	2
Glucocorticoid receptor-like (DNA-binding domain)	Lipocalins	2	1
EGF/Laminin	CalX-like	2	2
MIR domain	ARM repeat	2	2
Tricorn protease domain 2	TPR-like	2	1
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	2	1
RNase III domain-like	dsRNA-binding domain-like	2	2
PAP/OAS1 substrate-binding domain	PAP/OAS1 substrate-binding domain	2	2
FabD/lysophospholipase-like	FabD/lysophospholipase-like	2	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	2	1
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	2	1
CAD & PB1 domains	Cysteine-rich domain	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	2
EGF/Laminin	Tropomyosin	2	2
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	2	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	2	1
PAP/OAS1 substrate-binding domain	Retrovirus zinc finger-like domains	2	2
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	2	2
Mib/herc2 domain-like	Galactose-binding domain-like	2	2
L domain-like	DNase I-like	2	1
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	2	2
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	2	2
GST C-terminal domain-like	Class II aaRS ABD-related	2	2
Growth factor receptor domain	Chicken cartilage matrix protein	2	2
WD40 repeat-like	SNARE fusion complex	2	2
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	2	2
Spermadhesin, CUB domain	Cystine-knot cytokines	2	1
RUN domain-like	RUN domain-like	2	1
BRK domain-like	Bromodomain	2	1
Tudor/PWWP/MBT	HIT/MYND zinc finger-like	2	2
Spermadhesin, CUB domain	Kelch motif	2	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	2
GINS helical bundle-like	PriA/YqbF domain	2	2
Cytochrome b5-like heme/steroid binding domain	HSP20-like chaperones	2	2
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	2	2
PLP-dependent transferases	PLP-dependent transferases	2	1
TAZ domain	TAZ domain	2	2
RNA-binding domain, RBD	UBA-like	2	2
GST C-terminal domain-like	Class II aaRS and biotin synthetases	2	2
Methionine synthase domain	Methionine synthase activation domain-like	2	2
CalX-like	Fibronectin type III	2	2
vWA-like	BPTI-like	2	2
Telomeric repeat binding factor (TRF) dimerisation domain	Homeodomain-like	2	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	2	1
F-box domain	PH domain-like	2	2
B-box zinc-binding domain	beta-beta-alpha zinc fingers	2	2
GDNF receptor-like	GDNF receptor-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	2	1
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	2	1
PUG domain-like	Galactose-binding domain-like	2	1
dsRNA-binding domain-like	R3H domain	2	1
DNA-binding domain	SET domain	2	1
Assembly domain of cartilage oligomeric matrix protein	TSP type-3 repeat	2	2
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	2	1
cAMP-binding domain-like	PDZ domain-like	2	2
Ankyrin repeat	SET domain	2	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NagB/RpiA/CoA transferase-like	2	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	2	1
R3H domain	P-loop containing nucleoside triphosphate hydrolases	2	2
SAP domain	RING/U-box	2	2
ARID-like	Chromo domain-like	2	2
EGF/Laminin	Ankyrin repeat	2	2
Nitric oxide (NO) synthase oxygenase domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
SMAD/FHA domain	Cap-Gly domain	2	1
HR1 repeat	HR1 repeat	2	1
FF domain	GTPase activation domain, GAP	2	1
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	2	2
PKD domain	BPTI-like	2	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
Ankyrin repeat	EF-hand	2	2
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	2	2
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	2	2
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	2	2
PK beta-barrel domain-like	PK C-terminal domain-like	2	1
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	2	1
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	2	2
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	2	1
CRAL/TRIO domain	Immunoglobulin	2	1
L domain-like	Ubiquitin-like	2	1
Cupredoxins	Galactose-binding domain-like	2	2
UBC-like	UBA-like	2	1
N-terminal coiled coil domain from apc	Tumor suppressor gene product Apc	2	1
p53 tetramerization domain	SAM/Pointed domain	2	2
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	2	1
E set domains	AMPKBI-like	2	2
Saposin	Saposin	2	2
Galactose-binding domain-like	BRCT domain	2	1
Assembly domain of cartilage oligomeric matrix protein	EGF/Laminin	2	2
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	2	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	2	1
Galactose-binding domain-like	RING/U-box	2	2
Chromo domain-like	SET domain	2	2
Protein kinase-like (PK-like)	MIT domain	2	2
WWE domain	Hect, E3 ligase catalytic domain	2	1
Somatomedin B domain	Hemopexin-like domain	2	2
Ankyrin repeat	Eukaryotic type KH-domain (KH-domain type I)	2	1
N-terminal coiled coil domain from apc	ARM repeat	2	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	2	1
Tumor suppressor gene product Apc	ARM repeat	2	1
GST C-terminal domain-like	S15/NS1 RNA-binding domain	2	2
Homeodomain-like	FAD-linked reductases, C-terminal domain	2	2
Thioredoxin-like	Six-hairpin glycosidases	2	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	2	2
Tricorn protease domain 2	DPP6 N-terminal domain-like	2	1
Histone-fold	Histone-fold	2	2
Second domain of FERM	DBL homology domain (DH-domain)	2	2
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Fibronectin type III	2	2
Mib/herc2 domain-like	RING/U-box	2	1
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	1
Cysteine proteinases	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
RING/U-box	Trimerization domain of TRAF	2	2
Myosin rod fragments	G protein-binding domain	2	1
SMAD/FHA domain	RING/U-box	2	2
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	2	2
Actin-like ATPase domain	AF1104-like	2	2
PX domain	MIT domain	2	1
Immunoglobulin	3-carboxy-cis,cis-mucoante lactonizing enzyme	2	1
BRCT domain	Ankyrin repeat	2	2
Second domain of FERM	RING/U-box	2	1
Integrin beta tail domain	Fibronectin type III	2	2
Immunoglobulin	Heme-dependent peroxidases	2	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
Chaperone J-domain	CSL zinc finger	2	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	2	1
ARM repeat	Zn-dependent exopeptidases	2	2
Annexin	Annexin	2	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	2	1
"Winged helix" DNA-binding domain	Acyl-CoA N-acyltransferases (Nat)	2	2
Flavoproteins	Radical SAM enzymes	2	1
N-terminal domain of cbl (N-cbl)	RING/U-box	2	1
Assembly domain of cartilage oligomeric matrix protein	Concanavalin A-like lectins/glucanases	2	2
Nucleotidylyl transferase	C-terminal domain of ProRS	2	2
DPP6 N-terminal domain-like	TPR-like	2	1
Second domain of FERM	SH3-domain	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	2
LDL receptor-like module	Frizzled cysteine-rich domain	2	2
TAZ domain	Kix domain of CBP (creb binding protein)	2	2
Frizzled cysteine-rich domain	Carboxypeptidase regulatory domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	2	2
Galactose-binding domain-like	Fibrinogen C-terminal domain-like	2	2
SPOC domain-like	C-terminal domain of Ku80	2	1
R3H domain	Ribonuclease H-like	2	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	2	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	2	2
Tudor/PWWP/MBT	HMG-box	2	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	2	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	2	1
Histone-fold	Macro domain-like	2	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	2	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	2	1
L9 N-domain-like	Ribonuclease H-like	2	1
PKD domain	LDL receptor-like module	2	1
FYVE/PHD zinc finger	PUA domain-like	2	2
FnI-like domain	Kringle-like	2	2
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	2	2
Ankyrin repeat	ARM repeat	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Nucleotidyltransferase substrate binding subunit/domain	2	2
L domain-like	PKD domain	2	2
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	2	1
Taf5 N-terminal domain-like	WD40 repeat-like	2	2
EF-hand	UBA-like	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Chaperone J-domain	2	2
Galactose-binding domain-like	Hect, E3 ligase catalytic domain	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	2	1
Metallo-dependent phosphatases	EF-hand	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Eferin C-derminal domain-like	2	1
Nucleotide-diphospho-sugar transferases	ARM repeat	2	1
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	2	2
Kelch motif	C-type lectin-like	2	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
FYVE/PHD zinc finger	Hect, E3 ligase catalytic domain	2	2
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	2
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	2	1
EGF/Laminin	Fibrinogen C-terminal domain-like	2	2
RNA-binding domain, RBD	Cyclophilin-like	2	2
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
Kazal-type serine protease inhibitors	PDZ domain-like	2	2
Cysteine proteinases	Galactose-binding domain-like	2	1
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	2	2
Galactose-binding domain-like	Ankyrin repeat	2	2
PDZ domain-like	BAR/IMD domain-like	2	1
Nucleotidyltransferase	Nucleotidyltransferase	2	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	2	1
Carbonic anhydrase	Fibronectin type III	2	2
Putative DNA-binding domain	SAND domain-like	2	1
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	2
Nucleic acid-binding proteins	BRCT domain	2	2
LCCL domain	LCCL domain	2	1
L domain-like	DEATH domain	2	2
Tricorn protease domain 2	ADP-ribosylglycohydrolase	2	1
Sialidases	Sialidases	2	2
CCCH zinc finger	Retrovirus zinc finger-like domains	2	2
Glucocorticoid receptor-like (DNA-binding domain)	VHP, Villin headpiece domain	2	2
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	2	2
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	2	2
TPR-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
BRCT domain	DNA/RNA polymerases	2	1
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	2	1
Kelch motif	EGF/Laminin	2	1
Myosin S1 fragment, N-terminal domain	Myosin rod fragments	2	2
Galactose-binding domain-like	Carboxypeptidase regulatory domain-like	2	2
TAZ domain	RING/U-box	2	2
"Winged helix" DNA-binding domain	E set domains	2	2
P-loop containing nucleoside triphosphate hydrolases	PX domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	2	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	2	1
TPR-like	Clavaminate synthase-like	2	2
TRAF domain-like	POZ domain	2	1
Formin homology 2 domain (FH2 domain)	Protein kinase-like (PK-like)	2	2
SWIB/MDM2 domain	RING/U-box	2	1
ITPase-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Ubiquitin-like	AN1-like Zinc finger	2	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
Thioredoxin-like	NHL repeat	2	1
TPR-like	HSP20-like chaperones	2	1
UBA-like	XPC-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	LigT-like	2	1
ENTH/VHS domain	I/LWEQ domain	2	1
Chaperone J-domain	RNA-binding domain, RBD	2	1
Nitric oxide (NO) synthase oxygenase domain	Flavoproteins	2	2
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	2	2
Integrin beta tail domain	CalX-like	2	2
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	2	2
Galactose-binding domain-like	ARM repeat	2	2
POZ domain	Galactose-binding domain-like	2	1
NAD kinase/diacylglycerol kinase-like	SAM/Pointed domain	2	2
Kazal-type serine protease inhibitors	SRCR-like	2	2
VPS9 domain	Ubiquitin-like	2	1
RCC1/BLIP-II	RCC1/BLIP-II	2	2
PreATP-grasp domain	ClpP/crotonase	2	1
p53-like transcription factors	SAM/Pointed domain	2	2
Phenylalanine zipper	SH2 domain	2	1
Thioredoxin-like	FAD-dependent thiol oxidase	2	1
Pectin lyase-like	Pectin lyase-like	2	2
GLA-domain	Growth factor receptor domain	2	1
TPR-like	beta-beta-alpha zinc fingers	2	2
Ribonuclease H-like	HRDC-like	2	2
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	2	2
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	2	2
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
Class II aaRS ABD-related	C-terminal domain of ProRS	2	2
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	2	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	2
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	2	2
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	2	1
p53-like transcription factors	DEATH domain	2	1
Homeodomain-like	FAD/NAD(P)-binding domain	2	2
Trimerization domain of TRAF	TRAF domain-like	2	2
TRAF domain-like	F-box domain	2	2
Macro domain-like	WWE domain	2	1
CAD & PB1 domains	C-terminal domain of DFF45/ICAD (DFF-C domain)	2	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
Amine oxidase N-terminal region	Amine oxidase catalytic domain	2	2
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	2	2
Class II aaRS and biotin synthetases	Translation proteins	2	1
ARM repeat	RING/U-box	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Chaperone J-domain	2	2
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	2	2
ITPase-like	"Winged helix" DNA-binding domain	2	1
FYVE/PHD zinc finger	SAP domain	2	2
Protein kinase-like (PK-like)	Myosin rod fragments	2	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
"Winged helix" DNA-binding domain	HRDC-like	2	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	1
Ran binding protein zinc finger-like	RING/U-box	2	1
HD-domain/PDEase-like	HD-domain/PDEase-like	2	2
"Winged helix" DNA-binding domain	cAMP-binding domain-like	2	2
RCC1/BLIP-II	PABC (PABP) domain	2	2
GLA-domain	Concanavalin A-like lectins/glucanases	2	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	2	2
vWA-like	C-terminal domain of Ku80	2	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	2	1
GST C-terminal domain-like	Ribosomal protein L25-like	2	2
HMG-box	FYVE/PHD zinc finger	2	1
PYP-like sensor domain (PAS domain)	HD-domain/PDEase-like	2	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	2	2
TAZ domain	Bromodomain	2	2
Nucleotidyltransferase	Retrovirus zinc finger-like domains	2	2
EF-hand	3-carboxy-cis,cis-mucoante lactonizing enzyme	2	1
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	2	2
TSP-1 type 1 repeat	GFP-like	2	1
Spermadhesin, CUB domain	Family A G protein-coupled receptor-like	2	1
Tudor/PWWP/MBT	ARID-like	2	2
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	2	1
Plexin repeat	CalX-like	2	2
WW domain	GTPase activation domain, GAP	2	2
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	2	1
HMG-box	SET domain	2	1
RNI-like	Toll/Interleukin receptor TIR domain	2	2
CBS-domain pair	CBS-domain pair	2	2
SH2 domain	RING/U-box	2	1
Chaperone J-domain	Nucleotidyltransferase substrate binding subunit/domain	2	2
SAP domain	EF-hand	2	1
Ribosomal protein S5 domain 2-like	HMG-box	2	1
Translation proteins	ThrRS/AlaRS common domain	2	1
Galactose-binding domain-like	Zn-dependent exopeptidases	2	2
WD40 repeat-like	SOCS box-like	2	2
PheT/TilS domain	Class II aaRS and biotin synthetases	2	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	2	1
Seven-hairpin glycosidases	PA domain	2	2
MIT domain	Calpain large subunit, middle domain (domain III)	2	1
SWIB/MDM2 domain	SWIB/MDM2 domain	2	1
TPR-like	CAD & PB1 domains	2	2
PRTase-like	PRTase-like	2	1
L domain-like	FnI-like domain	2	2
Single hybrid motif	ClpP/crotonase	2	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	2	1
Nitric oxide (NO) synthase oxygenase domain	Riboflavin synthase domain-like	2	2
Chaperone J-domain	Thioredoxin-like	2	2
Cyclophilin-like	TPR-like	2	2
Cysteine-rich domain	SH3-domain	2	2
Kazal-type serine protease inhibitors	3-carboxy-cis,cis-mucoante lactonizing enzyme	2	1
Calponin-homology domain, CH-domain	Ubiquitin-like	2	1
Nucleic acid-binding proteins	SAP domain	2	1
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	1
Kazal-type serine protease inhibitors	LDL receptor-like module	2	2
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	2	1
vWA-like	CalX-like	2	2
GST C-terminal domain-like	C-terminal domain of ProRS	2	2
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	2
AN1-like Zinc finger	AN1-like Zinc finger	2	2
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	2	1
PH domain-like	Immunoglobulin	2	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	2	1
GTPase activation domain, GAP	RGC domain-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HMG-box	2	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	2	1
Growth factor receptor domain	Ankyrin repeat	2	2
Metalloproteases ("zincins"), catalytic domain	Kringle-like	2	2
FAS1 domain	C-type lectin-like	2	2
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	2	1
TGS-like	Class II aaRS and biotin synthetases	2	2
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
Nucleic acid-binding proteins	EF-hand	2	1
Quinoprotein alcohol dehydrogenase-like	Ypt/Rab-GAP domain of gyp1p	2	1
E set domains	DEATH domain	2	1
NagB/RpiA/CoA transferase-like	RNA-binding domain, RBD	2	1
Voltage-gated potassium channels	EF-hand	2	1
Phenylalanine zipper	PH domain-like	2	1
Kringle-like	HCP-like	2	1
SAM/Pointed domain	RING/U-box	2	2
L domain-like	Hormone receptor domain	2	1
WWE domain	WWE domain	2	2
p53-like transcription factors	Ankyrin repeat	2	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	2	2
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Ankyrin repeat	Hect, E3 ligase catalytic domain	2	2
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	2	1
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	2	1
SRCR-like	Spermadhesin, CUB domain	2	2
L domain-like	Heme-dependent peroxidases	2	2
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	2	1
Zinc beta-ribbon	Cyclin-like	2	2
(Phosphotyrosine protein) phosphatases II	Chaperone J-domain	2	2
cAMP-binding domain-like	FabD/lysophospholipase-like	2	1
EF-hand	Rhomboid-like	2	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	2	1
ARM repeat	HMA, heavy metal-associated domain	2	1
Complement control module/SCR domain	Concanavalin A-like lectins/glucanases	2	2
L domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	2	2
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	2	2
Cap-Gly domain	Cysteine proteinases	2	2
Calponin-homology domain, CH-domain	E set domains	2	2
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	2	2
ArfGap/RecO-like zinc finger	GTPase activation domain, GAP	2	2
Ubiquitin-like	RING/U-box	2	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	2	2
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	2	1
EF-hand	Immunoglobulin	2	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-beta-alpha zinc fingers	2	2
Rudiment single hybrid motif	ClpP/crotonase	2	1
YWTD domain	Protein kinase-like (PK-like)	2	1
P-loop containing nucleoside triphosphate hydrolases	Cap-Gly domain	2	1
CCCH zinc finger	beta-beta-alpha zinc fingers	2	2
DAK1/DegV-like	DhaL-like	2	1
Bromodomain	RING/U-box	2	2
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	2	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	2	2
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	2	2
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	2	1
NAD(P)-binding Rossmann-fold domains	NagB/RpiA/CoA transferase-like	2	1
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase C-terminal domain-like	2	2
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	2	1
ARID-like	Clavaminate synthase-like	2	2
CCCH zinc finger	P-loop containing nucleoside triphosphate hydrolases	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
TGS-like	Class II aaRS ABD-related	2	2
Growth factor receptor domain	Notch domain	2	2
Cysteine proteinases	Tudor/PWWP/MBT	2	2
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	2	2
SMAD/FHA domain	PX domain	2	1
Tudor/PWWP/MBT	Chromo domain-like	2	2
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	2	1
"Winged helix" DNA-binding domain	occludin/ELL-like	2	1
RNase III domain-like	RNase III domain-like	2	2
PDZ domain-like	PX domain	2	1
P-loop containing nucleoside triphosphate hydrolases	RGC domain-like	2	2
ISP domain	FAD/NAD(P)-binding domain	2	2
Metalloproteases ("zincins"), catalytic domain	Complement control module/SCR domain	2	2
PUG domain-like	Cysteine proteinases	2	1
TPR-like	ARM repeat	2	2
Dihydropteroate synthetase-like	Methionine synthase domain	2	2
tRNA-binding arm	Class II aaRS and biotin synthetases	2	2
Carbonic anhydrase	(Phosphotyrosine protein) phosphatases II	2	2
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	2	1
Ribosomal protein L25-like	C-terminal domain of ProRS	2	2
BRCT domain	ADP-ribosylation	2	2
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	2	2
TPR-like	Protein kinase-like (PK-like)	2	2
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	2	2
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	2	1
PUA domain-like	Ribosomal protein S5 domain 2-like	2	1
Acyl-CoA binding protein	Ankyrin repeat	2	1
Cadherin-like	Dystroglycan, domain 2	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	1
LDL receptor-like module	Fibronectin type III	2	2
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
Myosin rod fragments	PH domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	2	2
PR-1-like	LCCL domain	2	1
R3H domain	RNA-binding domain, RBD	2	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	2	2
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	2	2
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	2	1
DUSP-like	DUSP-like	2	1
Tudor/PWWP/MBT	HIV integrase-binding domain	2	1
HSP20-like chaperones	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
DBL homology domain (DH-domain)	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	2
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	2	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	2	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	2	2
SH3-domain	Immunoglobulin	2	1
Plexin repeat	Fibronectin type III	2	2
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
F-box domain	DBL homology domain (DH-domain)	2	2
TSP-1 type 1 repeat	BPTI-like	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	2	2
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	2	2
Glucocorticoid receptor-like (DNA-binding domain)	Protein kinase-like (PK-like)	2	2
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	2	2
C-terminal, gelsolin-like domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	2	2
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	2	1
Mib/herc2 domain-like	Mib/herc2 domain-like	2	1
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	1
DBL homology domain (DH-domain)	Immunoglobulin	2	1
Myosin rod fragments	Cysteine-rich domain	2	1
RING/U-box	RNA-binding domain, RBD	2	2
Kelch motif	Fibronectin type III	2	1
WGR domain-like	ADP-ribosylation	1	1
PurS-like	Class I glutamine amidotransferase-like	1	1
Growth factor receptor domain	Leech antihemostatic proteins	1	1
Trefoil	Glycosyl hydrolase domain	1	1
Heme-dependent peroxidases	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
EGF/Laminin	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
GroES-like	ACP-like	1	1
Cysteine proteinases	Globin-like	1	1
B-box zinc-binding domain	TRAF domain-like	1	1
IP3 receptor type 1 binding core, domain 2	ARM repeat	1	1
PGBD-like	Kringle-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Mib/herc2 domain-like	Tudor/PWWP/MBT	1	1
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	1	1
TRADD, N-terminal domain	DEATH domain	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
ARM repeat	Mib/herc2 domain-like	1	1
C-type lectin-like	Fibronectin type III	1	1
PX domain	CAD & PB1 domains	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
TPR-like	Protein prenylyltransferase	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
Growth factor receptor domain	FYVE/PHD zinc finger	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
Heme-dependent peroxidases	Riboflavin synthase domain-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
Acyl-CoA binding protein	ClpP/crotonase	1	1
Protein kinase-like (PK-like)	Ypt/Rab-GAP domain of gyp1p	1	1
Ricin B-like lectins	Fibronectin type III	1	1
Glutathione synthetase ATP-binding domain-like	Aldolase	1	1
Trefoil	Trefoil	1	1
PH domain-like	alpha-catenin/vinculin-like	1	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	1	1
Ubiquitin-like	A middle domain of Talin 1	1	1
N-acetylmuramoyl-L-alanine amidase-like	N-acetylmuramoyl-L-alanine amidase-like	1	1
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
FAS1 domain	Growth factor receptor domain	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
CRAL/TRIO N-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
Intermediate filament protein, coiled coil region	ALDH-like	1	1
F-box domain	Sec7 domain	1	1
Bcr-Abl oncoprotein oligomerization domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
Concanavalin A-like lectins/glucanases	HCP-like	1	1
Fibronectin type III	BPTI-like	1	1
I/LWEQ domain	alpha-catenin/vinculin-like	1	1
TAZ domain	Nuclear receptor coactivator interlocking domain	1	1
PH domain-like	L domain-like	1	1
E set domains	Protein kinase-like (PK-like)	1	1
Ubiquitin-like	HAD-like	1	1
BRCT domain	PH domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	DHS-like NAD/FAD-binding domain	1	1
PUA domain-like	eIF1-like	1	1
DEATH domain	Tropomyosin	1	1
UBA-like	Tudor/PWWP/MBT	1	1
vWA-like	Cysteine-rich domain	1	1
Ankyrin repeat	WD40 repeat-like	1	1
PAZ domain	RNase III domain-like	1	1
Concanavalin A-like lectins/glucanases	SOCS box-like	1	1
Ankyrin repeat	DBL homology domain (DH-domain)	1	1
Concanavalin A-like lectins/glucanases	C-type lectin-like	1	1
Growth factor receptor domain	PDZ domain-like	1	1
BSD domain-like	BSD domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
FMN-linked oxidoreductases	4Fe-4S ferredoxins	1	1
RING/U-box	Prefoldin	1	1
post-HMGL domain-like	Single hybrid motif	1	1
Zinc hairpin stack	RING/U-box	1	1
UBA-like	Phosphoglycerate mutase-like	1	1
Tudor/PWWP/MBT	Protein kinase-like (PK-like)	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
PH domain-like	PP2C-like	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
Saposin	SGNH hydrolase	1	1
Galactose oxidase, central domain	EGF/Laminin	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
PMP inhibitors	Cysteine proteinases	1	1
Ras GEF	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
PAH2 domain	Homeodomain-like	1	1
Ribonuclease Rh-like	Ribonuclease Rh-like	1	1
Zn-finger domain of Sec23/24	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
GLA-domain	Kringle-like	1	1
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	1	1
Ubiquitin-like	DBL homology domain (DH-domain)	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Mitotic arrest deficient-like 1, Mad1	1	1
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Rhomboid-like	UBA-like	1	1
RCC1/BLIP-II	Tudor/PWWP/MBT	1	1
Alpha-macroglobulin receptor domain	Kazal-type serine protease inhibitors	1	1
Ubiquitin-like	Acid proteases	1	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
PH domain-like	BSD domain-like	1	1
FnI-like domain	Leech antihemostatic proteins	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
PH domain-like	Cyclophilin-like	1	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	1	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	1	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	1	1
SMI1/KNR4-like	ApaG-like	1	1
Spectrin repeat	Fibronectin type III	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
beta-sandwich domain of Sec23/24	beta-sandwich domain of Sec23/24	1	1
Inhibitor of apoptosis (IAP) repeat	DEATH domain	1	1
BRCT domain	Homeodomain-like	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	1	1
PEP carboxykinase-like	PEP carboxykinase-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
SH3-domain	WW domain	1	1
Proteasome activator	Amine oxidase catalytic domain	1	1
DBL homology domain (DH-domain)	VPS9 domain	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
Thyroglobulin type-1 domain	YWTD domain	1	1
Kix domain of CBP (creb binding protein)	Nuclear receptor coactivator interlocking domain	1	1
Formyltransferase	FMT C-terminal domain-like	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
Plexin repeat	Protein kinase-like (PK-like)	1	1
Rudiment single hybrid motif	Aldolase	1	1
PX domain	GTPase activation domain, GAP	1	1
Elafin-like	BPTI-like	1	1
Concanavalin A-like lectins/glucanases	FYVE/PHD zinc finger	1	1
DPP6 N-terminal domain-like	WD40 repeat-like	1	1
Fucose-specific lectin	Fucose-specific lectin	1	1
Ubiquitin-like	Nucleotidyltransferase substrate binding subunit/domain	1	1
PLC-like phosphodiesterases	PLC-like phosphodiesterases	1	1
P-loop containing nucleoside triphosphate hydrolases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Frizzled cysteine-rich domain	SRCR-like	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
PDZ domain-like	Cysteine-rich domain	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
TPR-like	Fic-like	1	1
Succinyl-CoA synthetase domains	NAD(P)-binding Rossmann-fold domains	1	1
Thiolase-like	FabD/lysophospholipase-like	1	1
GroES-like	alpha/beta-Hydrolases	1	1
Acid proteases	Acid proteases	1	1
Trefoil	(Trans)glycosidases	1	1
FAD-linked reductases, C-terminal domain	EF-hand	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
AF1104-like	AF1104-like	1	1
SMAD/FHA domain	DHS-like NAD/FAD-binding domain	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Folate-binding domain	TrmE connector domain	1	1
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
TRAF domain-like	NRDP1 C-terminal domain-like	1	1
Aldolase	AFP III-like domain	1	1
Carboxypeptidase regulatory domain-like	Calcium-dependent phosphotriesterase	1	1
"Winged helix" DNA-binding domain	dsRNA-binding domain-like	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
RNA-binding domain, RBD	PWI domain	1	1
HBS1-like domain	Translation proteins	1	1
Galactose oxidase, central domain	Galactose oxidase, central domain	1	1
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	1	1
WW domain	BAR/IMD domain-like	1	1
Invasin/intimin cell-adhesion fragments	Invasin/intimin cell-adhesion fragments	1	1
SAM/Pointed domain	HD-domain/PDEase-like	1	1
Plakin repeat	GAS2 domain-like	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Actin-like ATPase domain	1	1
Carboxypeptidase regulatory domain-like	Soluble quinoprotein glucose dehydrogenase	1	1
WD40 repeat-like	Actin depolymerizing proteins	1	1
ALDH-like	Periplasmic binding protein-like I	1	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
ACT-like	ACT-like	1	1
EGF/Laminin	TNF-like	1	1
Arginase/deacetylase	Arginase/deacetylase	1	1
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	1	1
WD40 repeat-like	Formin homology 2 domain (FH2 domain)	1	1
EF-hand	DUSP-like	1	1
Nucleotidyltransferase	Ubiquitin-like	1	1
RUN domain-like	PH domain-like	1	1
BPTI-like	TIMP-like	1	1
F-box domain	Kelch motif	1	1
SAP domain	Ribonuclease H-like	1	1
"Winged helix" DNA-binding domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	Transcription factor IIA (TFIIA), alpha-helical domain	1	1
PH domain-like	Bet v1-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
CalX-like	Tricorn protease domain 2	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
Second domain of FERM	I/LWEQ domain	1	1
BRCT domain	WGR domain-like	1	1
ARM repeat	RCC1/BLIP-II	1	1
Ankyrin repeat	Oxysterol-binding protein-like	1	1
Kringle-like	Spermadhesin, CUB domain	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	1	1
F-box domain	P-loop containing nucleoside triphosphate hydrolases	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
RCC1/BLIP-II	VPS9 domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	GroES-like	1	1
Galactose oxidase, central domain	FYVE/PHD zinc finger	1	1
FabD/lysophospholipase-like	alpha/beta-Hydrolases	1	1
Thiolase-like	SCP-like	1	1
WD40 repeat-like	TolB, C-terminal domain	1	1
RNA-binding domain, RBD	Class II aaRS ABD-related	1	1
R3H domain	Ankyrin repeat	1	1
Cytochrome b5-like heme/steroid binding domain	Mib/herc2 domain-like	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
Carboxypeptidase regulatory domain-like	Immunoglobulin	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
ARID-like	"Winged helix" DNA-binding domain	1	1
G protein-binding domain	G protein-binding domain	1	1
His-Me finger endonucleases	HIT/MYND zinc finger-like	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
Frizzled cysteine-rich domain	Trypsin-like serine proteases	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
Calponin-homology domain, CH-domain	WW domain	1	1
PDZ domain-like	Nitric oxide (NO) synthase oxygenase domain	1	1
CCCH zinc finger	ADP-ribosylation	1	1
Pseudouridine synthase	PUA domain-like	1	1
DNase I-like	RNA-binding domain, RBD	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
RmlC-like cupins	RmlC-like cupins	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
Trefoil	Galactose mutarotase-like	1	1
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	1	1
Kringle-like	Hemopexin-like domain	1	1
Staphylococcal nuclease	Protein kinase-like (PK-like)	1	1
SAND domain-like	HIT/MYND zinc finger-like	1	1
WD40 repeat-like	SAM/Pointed domain	1	1
Tudor/PWWP/MBT	S-adenosyl-L-methionine-dependent methyltransferases	1	1
POZ domain	FYVE/PHD zinc finger	1	1
I/LWEQ domain	I/LWEQ domain	1	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
TPR-like	UBA-like	1	1
EGF/Laminin	SEA domain	1	1
Terpenoid cyclases/Protein prenyltransferases	Kazal-type serine protease inhibitors	1	1
Protein kinase-like (PK-like)	Chaperone J-domain	1	1
Succinyl-CoA synthetase domains	Citrate synthase	1	1
FYVE/PHD zinc finger	SMAD/FHA domain	1	1
Cytochrome P450	Cytochrome P450	1	1
Outer arm dynein light chain 1	Polo-box domain	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	Tricorn protease domain 2	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Triple coiled coil domain of C-type lectins	C-type lectin-like	1	1
HAD-like	BRCT domain	1	1
GFP-like	YWTD domain	1	1
LDL receptor-like module	C-type lectin-like	1	1
Thioredoxin-like	Nucleoside diphosphate kinase, NDK	1	1
Sema domain	Protein kinase-like (PK-like)	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
Complement control module/SCR domain	Growth factor receptor domain	1	1
Cysteine-rich domain	SAM/Pointed domain	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
alpha-helical ferredoxin	FMN-linked oxidoreductases	1	1
Spectrin repeat	GAS2 domain-like	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PDZ domain-like	Flavoproteins	1	1
Aldolase	post-HMGL domain-like	1	1
Ribonuclease H-like	Zinc finger domain of DNA polymerase-alpha	1	1
Doublecortin (DC)	POZ domain	1	1
WW domain	BAG domain	1	1
Carbamate kinase-like	ALDH-like	1	1
Nucleotide-binding domain	FMN-linked oxidoreductases	1	1
Amyloid beta a4 protein copper binding domain (domain 2)	BPTI-like	1	1
BRCA2 helical domain	Nucleic acid-binding proteins	1	1
BRK domain-like	BRK domain-like	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
DNA-binding domain	FYVE/PHD zinc finger	1	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	1	1
SMAD/FHA domain	HIT-like	1	1
DNase I-like	DNase I-like	1	1
Growth factor receptor domain	alpha/beta-Hydrolases	1	1
HAD-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
TSP-1 type 1 repeat	Carboxypeptidase regulatory domain-like	1	1
Homeodomain-like	JAB1/MPN domain	1	1
ISP domain	Bet v1-like	1	1
SH3-domain	RUN domain-like	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	1	1
NHL repeat	Soluble quinoprotein glucose dehydrogenase	1	1
Phospholipase A2, PLA2	Phospholipase A2, PLA2	1	1
FYVE/PHD zinc finger	Supernatant protein factor (SPF), C-terminal domain	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
Nucleotide-binding domain	4Fe-4S ferredoxins	1	1
Calponin-homology domain, CH-domain	PDZ domain-like	1	1
VPS9 domain	Ankyrin repeat	1	1
EF-hand	Myosin rod fragments	1	1
beta-sandwich domain of Sec23/24	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
RNA-binding domain, RBD	PAP/OAS1 substrate-binding domain	1	1
Doublecortin (DC)	Protein kinase-like (PK-like)	1	1
Glucocorticoid receptor-like (DNA-binding domain)	KRAB domain (Kruppel-associated box)	1	1
Retrovirus zinc finger-like domains	RING/U-box	1	1
Protein kinase-like (PK-like)	Rhodanese/Cell cycle control phosphatase	1	1
Mannose 6-phosphate receptor domain	Kringle-like	1	1
GroEL-intermediate domain like	SAICAR synthase-like	1	1
GFP-like	Thyroglobulin type-1 domain	1	1
Helical domain of Sec23/24	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
RING/U-box	R3H domain	1	1
WGR domain-like	Domain of poly(ADP-ribose) polymerase	1	1
Ran binding protein zinc finger-like	Cyclophilin-like	1	1
KRAB domain (Kruppel-associated box)	SET domain	1	1
vWA-like	Sensory domain-like	1	1
RNA-binding domain, RBD	Clavaminate synthase-like	1	1
Integrin alpha N-terminal domain	Quinoprotein alcohol dehydrogenase-like	1	1
Chaperone J-domain	Chaperone J-domain	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
A heparin-binding domain	BPTI-like	1	1
L domain-like	PP2C-like	1	1
Galactose-binding domain-like	Kelch motif	1	1
WD40 repeat-like	Hect, E3 ligase catalytic domain	1	1
FabD/lysophospholipase-like	ACP-like	1	1
Tubulin nucleotide-binding domain-like	Tubulin nucleotide-binding domain-like	1	1
RCC1/BLIP-II	Cytochrome b5-like heme/steroid binding domain	1	1
Tropomyosin	Tropomyosin	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
SH3-domain	Phosphoglycerate mutase-like	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
BAR/IMD domain-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
TRAF domain-like	EGF/Laminin	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
PLC-like phosphodiesterases	Ubiquitin-like	1	1
Carboxypeptidase regulatory domain-like	DPP6 N-terminal domain-like	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
HAD-like	Protein kinase-like (PK-like)	1	1
Tex N-terminal region-like	Ribonuclease H-like	1	1
WD40 repeat-like	Cysteine proteinases	1	1
Chromo domain-like	ClpP/crotonase	1	1
PRP4-like	WD40 repeat-like	1	1
UBC-like	NAD(P)-binding Rossmann-fold domains	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
HAD-like	HAD-like	1	1
Ankyrin repeat	MFS general substrate transporter	1	1
ARM repeat	FYVE/PHD zinc finger	1	1
Ribonuclease H-like	P-loop containing nucleoside triphosphate hydrolases	1	1
SAM/Pointed domain	Retrovirus zinc finger-like domains	1	1
ISP domain	P-loop containing nucleoside triphosphate hydrolases	1	1
FYVE/PHD zinc finger	Rabenosyn-5 Rab-binding domain-like	1	1
PH domain-like	Acid proteases	1	1
Ubiquitin-like	SAM/Pointed domain	1	1
FabD/lysophospholipase-like	GroES-like	1	1
Class I glutamine amidotransferase-like	Class I glutamine amidotransferase-like	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
alpha-helical ferredoxin	4Fe-4S ferredoxins	1	1
P-loop containing nucleoside triphosphate hydrolases	Cation efflux protein transmembrane domain-like	1	1
FMN-linked oxidoreductases	dsRNA-binding domain-like	1	1
FAD/NAD(P)-binding domain	NAD(P)-binding Rossmann-fold domains	1	1
TRAF domain-like	Cysteine proteinases	1	1
FnI-like domain	Trypsin-like serine proteases	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Ubiquitin-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Kazal-type serine protease inhibitors	SEA domain	1	1
vWA-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
Class I glutamine amidotransferase-like	PreATP-grasp domain	1	1
TPR-like	Ran binding protein zinc finger-like	1	1
PH domain-like	HMG-box	1	1
POZ domain	Pentapeptide repeat-like	1	1
PHM/PNGase F	NHL repeat	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
IP3 receptor type 1 binding core, domain 2	Concanavalin A-like lectins/glucanases	1	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	1	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	1	1
ISP domain	POZ domain	1	1
TSP-1 type 1 repeat	Spermadhesin, CUB domain	1	1
RNI-like	EF-hand	1	1
Retrovirus zinc finger-like domains	P-loop containing nucleoside triphosphate hydrolases	1	1
Galactose oxidase, central domain	C-type lectin-like	1	1
Histone-fold	POZ domain	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
DHS-like NAD/FAD-binding domain	RING/U-box	1	1
LDL receptor-like module	L domain-like	1	1
Tudor/PWWP/MBT	Galactose-binding domain-like	1	1
Aldolase	Single hybrid motif	1	1
ARM repeat	EF-hand	1	1
USP8 N-terminal domain-like	Cysteine proteinases	1	1
Soluble quinoprotein glucose dehydrogenase	SRCR-like	1	1
beta-beta-alpha zinc fingers	WW domain	1	1
Fibrinogen C-terminal domain-like	Fibrinogen C-terminal domain-like	1	1
PH domain-like	I/LWEQ domain	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
Cap-Gly domain	RNI-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
RAP domain-like	RAP domain-like	1	1
R3H domain	AN1-like Zinc finger	1	1
Calponin-homology domain, CH-domain	Plakin repeat	1	1
E set domains	Kazal-type serine protease inhibitors	1	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	1	1
Outer arm dynein light chain 1	PDZ domain-like	1	1
DUSP-like	EPT/RTPC-like	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	1	1
PX domain	SAM/Pointed domain	1	1
Intermediate filament protein, coiled coil region	Periplasmic binding protein-like I	1	1
Ankyrin repeat	L domain-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
UBA-like	SMR domain-like	1	1
L domain-like	NTF2-like	1	1
POZ domain	Leucine zipper domain	1	1
Ubiquitin-like	BAG domain	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
RNI-like	Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain	1	1
RCC1/BLIP-II	Galactose-binding domain-like	1	1
Ankyrin repeat	FYVE/PHD zinc finger	1	1
HAD-like	Acyl-CoA dehydrogenase NM domain-like	1	1
Nucleotide-diphospho-sugar transferases	HAD-like	1	1
Cystatin/monellin	Cysteine proteinases	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
Kringle-like	Fibronectin type III	1	1
Heme-dependent peroxidases	Complement control module/SCR domain	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	C-terminal, gelsolin-like domain of Sec23/24	1	1
DNA-binding domain	Bromodomain	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
RNA-binding domain, RBD	dsRNA-binding domain-like	1	1
Ankyrin repeat	FabD/lysophospholipase-like	1	1
Serine protease inhibitors	vWA-like	1	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	1	1
TRAF domain-like	PDZ domain-like	1	1
DBL homology domain (DH-domain)	Fibronectin type III	1	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
PH domain-like	VPS9 domain	1	1
Pre-PUA domain	PUA domain-like	1	1
PreATP-grasp domain	post-HMGL domain-like	1	1
Carbonic anhydrase	Concanavalin A-like lectins/glucanases	1	1
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	1	1
Rap/Ran-GAP	Rap/Ran-GAP	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
DEATH domain	PDZ domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	1	1
Calponin-homology domain, CH-domain	RGC domain-like	1	1
p53-like transcription factors	p53-like transcription factors	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
E set domains	Hect, E3 ligase catalytic domain	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
ARM repeat	GTPase activation domain, GAP	1	1
PUG domain-like	Ubiquitin-like	1	1
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	1	1
WD40 repeat-like	SH3-domain	1	1
FabD/lysophospholipase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	Tryptophan synthase beta subunit-like PLP-dependent enzymes	1	1
Ubiquitin-like	FYVE/PHD zinc finger	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
ARM repeat	Toll/Interleukin receptor TIR domain	1	1
Ubiquitin-like	Chaperone J-domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
WD40 repeat-like	HMG-box	1	1
P-loop containing nucleoside triphosphate hydrolases	WW domain	1	1
Chromo domain-like	BRK domain-like	1	1
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	1	1
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	1	1
P-loop containing nucleoside triphosphate hydrolases	Polo-box domain	1	1
SET domain	WW domain	1	1
WD40 repeat-like	Cyclophilin-like	1	1
STAT	STAT	1	1
Chaperone J-domain	Homeodomain-like	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Ankyrin repeat	Cysteine-rich domain	1	1
Second domain of FERM	alpha-catenin/vinculin-like	1	1
F-box domain	RCC1/BLIP-II	1	1
ARM repeat	CRAL/TRIO domain	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
Hedgehog/DD-peptidase	Hedgehog/intein (Hint) domain	1	1
UBC-like	RING/U-box	1	1
WW domain	FKBP-like	1	1
RuvA domain 2-like	DNase I-like	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	1	1
Second domain of FERM	A middle domain of Talin 1	1	1
MHC antigen-recognition domain	MHC antigen-recognition domain	1	1
B-box zinc-binding domain	Apolipoprotein A-I	1	1
Cytochrome b5-like heme/steroid binding domain	Tudor/PWWP/MBT	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
TNF-like	TNF-like	1	1
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	1	1
LDL receptor-like module	Family A G protein-coupled receptor-like	1	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	1	1
F-box domain	Pectin lyase-like	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
RNA-binding domain, RBD	Nucleotidyltransferase	1	1
DNA clamp	DNA clamp	1	1
Ubiquitin-like	EPT/RTPC-like	1	1
Calponin-homology domain, CH-domain	GTPase activation domain, GAP	1	1
RING/U-box	NRDP1 C-terminal domain-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
RING/U-box	Apolipoprotein A-I	1	1
ACP-like	alpha/beta-Hydrolases	1	1
beta-beta-alpha zinc fingers	PAP/OAS1 substrate-binding domain	1	1
4-helical cytokines	4-helical cytokines	1	1
PH domain-like	Fibronectin type III	1	1
WD40 repeat-like	RCC1/BLIP-II	1	1
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	1	1
PH domain-like	A middle domain of Talin 1	1	1
ARID-like	FYVE/PHD zinc finger	1	1
PH domain-like	Cullin repeat-like	1	1
Kringle-like	SRCR-like	1	1
Growth factor receptor domain	Trypsin-like serine proteases	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
Ankyrin repeat	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	1	1
SPOC domain-like	SAP domain	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
Kazal-type serine protease inhibitors	FnI-like domain	1	1
Proteasome activator	Amine oxidase N-terminal region	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
PH domain-like	Ran binding protein zinc finger-like	1	1
Single hybrid motif	Single hybrid motif	1	1
Glutathione synthetase ATP-binding domain-like	Citrate synthase	1	1
UBC-like	LDH C-terminal domain-like	1	1
EF-hand	GAS2 domain-like	1	1
DEATH domain	WD40 repeat-like	1	1
Macro domain-like	CRAL/TRIO domain	1	1
TPR-like	HIT/MYND zinc finger-like	1	1
Cysteine-rich domain	(Phosphotyrosine protein) phosphatases II	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	1	1
EF-hand	Ubiquitin-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha/beta-Hydrolases	1	1
TPR-like	Metallo-dependent phosphatases	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
CalX-like	C-type lectin-like	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
Thioredoxin-like	ERP29 C domain-like	1	1
Nucleotide-binding domain	Nucleotide-binding domain	1	1
TRAF domain-like	Quinoprotein alcohol dehydrogenase-like	1	1
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	1	1
PH domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
RING/U-box	Quinoprotein alcohol dehydrogenase-like	1	1
AXH domain	HMG-box	1	1
Ubiquitin-like	I/LWEQ domain	1	1
HIT/MYND zinc finger-like	SET domain	1	1
Tricorn protease domain 2	Tricorn protease domain 2	1	1
ARM repeat	alpha/beta-Hydrolases	1	1
Bcr-Abl oncoprotein oligomerization domain	DBL homology domain (DH-domain)	1	1
RCC1/BLIP-II	DBL homology domain (DH-domain)	1	1
Ubiquitin-like	PUA domain-like	1	1
Ras GEF	PLC-like phosphodiesterases	1	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	1	1
L domain-like	PDZ domain-like	1	1
DEK C-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Spermadhesin, CUB domain	Frizzled cysteine-rich domain	1	1
Bromodomain	SET domain	1	1
PDZ domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
RNI-like	Ubiquitin-like	1	1
FnI-like domain	AbfB domain	1	1
RING/U-box	Nuclear receptor coactivator interlocking domain	1	1
Bromodomain	Nuclear receptor coactivator interlocking domain	1	1
Ribonuclease H-like	"Winged helix" DNA-binding domain	1	1
Doublecortin (DC)	Pentapeptide repeat-like	1	1
SAM/Pointed domain	SH2 domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
LEM domain	Ankyrin repeat	1	1
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
RCC1/BLIP-II	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
EF-hand	FnI-like domain	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
SAND domain-like	FYVE/PHD zinc finger	1	1
CBS-domain pair	cAMP-binding domain-like	1	1
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	1	1
BRCT domain	DBL homology domain (DH-domain)	1	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	1	1
PH domain-like	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
Elafin-like	Kazal-type serine protease inhibitors	1	1
Translation proteins	Initiation factor IF2/eIF5b, domain 3	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
DNA/RNA polymerases	Zinc finger domain of DNA polymerase-alpha	1	1
GTPase activation domain, GAP	VPS9 domain	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
Ribonuclease H-like	RuvA domain 2-like	1	1
SEA domain	SRCR-like	1	1
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
DNase I-like	GTPase activation domain, GAP	1	1
YccV-like	ApaG-like	1	1
Heme-dependent peroxidases	EF-hand	1	1
DNA-binding domain	DNA-glycosylase	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
Formin homology 2 domain (FH2 domain)	Concanavalin A-like lectins/glucanases	1	1
Growth factor receptor domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Ankyrin repeat	Second domain of FERM	1	1
Bcr-Abl oncoprotein oligomerization domain	PH domain-like	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
GroEL apical domain-like	SAICAR synthase-like	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
HBS1-like domain	P-loop containing nucleoside triphosphate hydrolases	1	1
WD40 repeat-like	TPR-like	1	1
Thioredoxin-like	Tropomyosin	1	1
Calponin-homology domain, CH-domain	Cysteine-rich domain	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
PAP/OAS1 substrate-binding domain	Ubiquitin-like	1	1
CCCH zinc finger	DHS-like NAD/FAD-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	ACP-like	1	1
PurS-like	PurM C-terminal domain-like	1	1
Glutaminase/Asparaginase	Ankyrin repeat	1	1
Elafin-like	Immunoglobulin	1	1
SWIB/MDM2 domain	eIF1-like	1	1
L30e-like	alpha/beta knot	1	1
EF-hand	Dimeric alpha+beta barrel	1	1
Cadherin-like	Protein kinase-like (PK-like)	1	1
BAR/IMD domain-like	Second domain of FERM	1	1
Notch domain	Notch domain	1	1
EGF/Laminin	Chicken cartilage matrix protein	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Smc hinge domain	1	1
Cytochrome b5-like heme/steroid binding domain	Galactose-binding domain-like	1	1
Calponin-homology domain, CH-domain	RING/U-box	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
Peptide methionine sulfoxide reductase	Trypsin-like serine proteases	1	1
PH domain-like	Glycolipid transfer protein, GLTP	1	1
Nitrous oxide reductase, N-terminal domain	WD40 repeat-like	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	Transcription factor IIA (TFIIA), beta-barrel domain	1	1
ARM repeat	L domain-like	1	1
Rudiment single hybrid motif	post-HMGL domain-like	1	1
beta-beta-alpha zinc fingers	Nucleotidyltransferase	1	1
A middle domain of Talin 1	alpha-catenin/vinculin-like	1	1
Kazal-type serine protease inhibitors	Concanavalin A-like lectins/glucanases	1	1
"Winged helix" DNA-binding domain	RING/U-box	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	1	1
Surp module (SWAP domain)	Ubiquitin-like	1	1
Thyroglobulin type-1 domain	alpha/beta-Hydrolases	1	1
FnI-like domain	RNI-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Chaperone J-domain	1	1
Putative DNA-binding domain	Cation efflux protein transmembrane domain-like	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
Elafin-like	TIMP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	1	1
Immunoglobulin	TIMP-like	1	1
BAR/IMD domain-like	SH2 domain	1	1
Somatomedin B domain	EndoU-like	1	1
Immunoglobulin	FnI-like domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	1	1
Outer arm dynein light chain 1	P-loop containing nucleoside triphosphate hydrolases	1	1
Ubiquitin-like	alpha-catenin/vinculin-like	1	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
POZ domain	A DNA-binding domain in eukaryotic transcription factors	1	1
PDZ domain-like	Riboflavin synthase domain-like	1	1
TPR-like	PH domain-like	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	EF-hand	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
DHH phosphoesterases	CRAL/TRIO domain	1	1
Cytochrome b5-like heme/steroid binding domain	E set domains	1	1
Ankyrin repeat	Nudix	1	1
Concanavalin A-like lectins/glucanases	SRCR-like	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
RING/U-box	Ribonuclease H-like	1	1
vWA-like	Trypsin-like serine proteases	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
(Trans)glycosidases	Acyl-CoA N-acyltransferases (Nat)	1	1
WD40 repeat-like	Tubby C-terminal domain-like	1	1
EF-hand	DBL homology domain (DH-domain)	1	1
Somatomedin B domain	TSP-1 type 1 repeat	1	1
dsRNA-binding domain-like	Protein kinase-like (PK-like)	1	1
Chondroitin AC/alginate lyase	P-loop containing nucleoside triphosphate hydrolases	1	1
Ubiquitin-like	Ran binding protein zinc finger-like	1	1
Growth factor receptor domain	CalX-like	1	1
Cytochrome b5-like heme/steroid binding domain	Hect, E3 ligase catalytic domain	1	1
Bromodomain	HIT/MYND zinc finger-like	1	1
CCCH zinc finger	WWE domain	1	1
TRAF domain-like	WD40 repeat-like	1	1
BAG domain	BAG domain	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	1	1
Outer arm dynein light chain 1	DEATH domain	1	1
BPTI-like	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
E set domains	Galactose-binding domain-like	1	1
Starch-binding domain-like	PLC-like phosphodiesterases	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	1	1
UBC-like	Ribosomal protein S5 domain 2-like	1	1
PX domain	Retrovirus zinc finger-like domains	1	1
EF-hand	Tropomyosin	1	1
Eukaryotic type KH-domain (KH-domain type I)	SAM/Pointed domain	1	1
Nucleic acid-binding proteins	TPR-like	1	1
E set domains	(Trans)glycosidases	1	1
Thioredoxin-like	Smc hinge domain	1	1
USP8 N-terminal domain-like	Rhodanese/Cell cycle control phosphatase	1	1
Protein kinase-like (PK-like)	RNA-binding domain, RBD	1	1
Histone-fold	Ankyrin repeat	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
NHL repeat	DPP6 N-terminal domain-like	1	1
SAM/Pointed domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Tudor/PWWP/MBT	Hect, E3 ligase catalytic domain	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
SAM/Pointed domain	Toll/Interleukin receptor TIR domain	1	1
TROVE domain-like	vWA-like	1	1
Doublecortin (DC)	Ricin B-like lectins	1	1
MIT domain	MIT domain	1	1
PDZ domain-like	Formin homology 2 domain (FH2 domain)	1	1
PurS-like	PurM N-terminal domain-like	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
NTF2-like	UBA-like	1	1
Bcr-Abl oncoprotein oligomerization domain	GTPase activation domain, GAP	1	1
A middle domain of Talin 1	I/LWEQ domain	1	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	1	1
Tropomyosin	beta-beta-alpha zinc fingers	1	1
Concanavalin A-like lectins/glucanases	Trypsin-like serine proteases	1	1
Bromodomain	HMG-box	1	1
CRAL/TRIO domain	PapD-like	1	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	1	1
POZ domain	WD40 repeat-like	1	1
Concanavalin A-like lectins/glucanases	Serine protease inhibitors	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Lipocalins	BPTI-like	1	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	1	1
Class II MHC-associated invariant chain ectoplasmic trimerization domain	Thyroglobulin type-1 domain	1	1
Pentapeptide repeat-like	Pentapeptide repeat-like	1	1
BAR/IMD domain-like	Protein kinase-like (PK-like)	1	1
Zn-dependent exopeptidases	Zn-dependent exopeptidases	1	1
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	1	1
SMAD/FHA domain	BRCT domain	1	1
Dcp2 domain-like	Nudix	1	1
ARM repeat	SAM/Pointed domain	1	1
Concanavalin A-like lectins/glucanases	RCC1/BLIP-II	1	1
C-terminal domain of adenylylcyclase associated protein	Nucleoside diphosphate kinase, NDK	1	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	1	1
RCC1/BLIP-II	Mib/herc2 domain-like	1	1
Thiolase-like	NAD(P)-binding Rossmann-fold domains	1	1
Calcium ATPase, transmembrane domain M	Calcium ATPase, transmembrane domain M	1	1
IP3 receptor type 1 binding core, domain 2	EF-hand	1	1
P-loop containing nucleoside triphosphate hydrolases	BAR/IMD domain-like	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
L domain-like	Putative isomerase YbhE	1	1
Ubiquitin-like	TPR-like	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
E set domains	Glycosyl hydrolase domain	1	1
NHL repeat	Calcium-dependent phosphotriesterase	1	1
BEACH domain	FYVE/PHD zinc finger	1	1
Oxidoreductase molybdopterin-binding domain	E set domains	1	1
Clavaminate synthase-like	RNI-like	1	1
Metallo-dependent phosphatases	HIT-like	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	CCCH zinc finger	1	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Eea1 homodimerisation domain	FYVE/PHD zinc finger	1	1
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
FYVE/PHD zinc finger	HIT/MYND zinc finger-like	1	1
SGNH hydrolase	SGNH hydrolase	1	1
S-adenosyl-L-methionine-dependent methyltransferases	ACP-like	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
Heme-dependent peroxidases	FnI-like domain	1	1
Translation proteins	Translation proteins	1	1
Plakin repeat	EF-hand	1	1
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	1	1
RNA-binding domain, RBD	L domain-like	1	1
PreATP-grasp domain	Aldolase	1	1
Thioredoxin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Ypt/Rab-GAP domain of gyp1p	SH3-domain	1	1
Formin homology 2 domain (FH2 domain)	Fibronectin type III	1	1
Spermadhesin, CUB domain	Galactose oxidase, central domain	1	1
ARM repeat	alpha/beta knot	1	1
alpha-helical ferredoxin	Nucleotide-binding domain	1	1
FnI-like domain	Fibronectin type III	1	1
Tudor/PWWP/MBT	BRCT domain	1	1
Ricin B-like lectins	(Phosphotyrosine protein) phosphatases II	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
ISP transmembrane anchor	ISP domain	1	1
Molybdenum cofactor biosynthesis proteins	Adenine nucleotide alpha hydrolases-like	1	1
NHL repeat	NHL repeat	1	1
GST C-terminal domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
RNA-binding domain, RBD	beta-beta-alpha zinc fingers	1	1
UBA-like	CCCH zinc finger	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
L domain-like	UBA-like	1	1
Cysteine proteinases	EPT/RTPC-like	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	1	1
Tropomyosin	KRAB domain (Kruppel-associated box)	1	1
beta-beta-alpha zinc fingers	Retrovirus zinc finger-like domains	1	1
Kazal-type serine protease inhibitors	BPTI-like	1	1
PH domain-like	RNI-like	1	1
RCC1/BLIP-II	PH domain-like	1	1
CRAL/TRIO domain	Fibronectin type III	1	1
beta-beta-alpha zinc fingers	Formin homology 2 domain (FH2 domain)	1	1
Kazal-type serine protease inhibitors	TIMP-like	1	1
Rabenosyn-5 Rab-binding domain-like	Rabenosyn-5 Rab-binding domain-like	1	1