Domain combination pairs in Sus scrofa 69_10.2

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

2298 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	447	179
Immunoglobulin	Immunoglobulin	243	91
KRAB domain (Kruppel-associated box)	beta-beta-alpha zinc fingers	152	57
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	115	43
Fibronectin type III	Fibronectin type III	104	74
EGF/Laminin	EGF/Laminin	104	86
Cadherin-like	Cadherin-like	88	30
RNA-binding domain, RBD	RNA-binding domain, RBD	74	27
Immunoglobulin	Fibronectin type III	62	50
DBL homology domain (DH-domain)	PH domain-like	61	39
RING/U-box	B-box zinc-binding domain	60	19
Actin-like ATPase domain	Actin-like ATPase domain	57	14
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	55	25
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	54	23
Intermediate filament protein, coiled coil region	Intermediate filament protein, coiled coil region	53	11
RING/U-box	Concanavalin A-like lectins/glucanases	51	13
TPR-like	TPR-like	51	21
PH domain-like	PH domain-like	46	28
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	45	9
EGF/Laminin	Growth factor receptor domain	44	43
Second domain of FERM	PH domain-like	43	27
ARM repeat	ARM repeat	42	24
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	42	5
POZ domain	beta-beta-alpha zinc fingers	42	22
L domain-like	L domain-like	40	25
TSP-1 type 1 repeat	TSP-1 type 1 repeat	40	33
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	39	6
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	39	10
HAD-like	Calcium ATPase, transmembrane domain M	38	11
Complement control module/SCR domain	Complement control module/SCR domain	38	33
POZ domain	Kelch motif	38	5
PDZ domain-like	PDZ domain-like	37	26
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	37	26
PH domain-like	SH3-domain	37	25
Retrovirus capsid dimerization domain-like	beta-beta-alpha zinc fingers	37	23
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	37	10
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	36	5
L domain-like	Immunoglobulin	36	14
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	34	8
Growth factor receptor domain	Growth factor receptor domain	34	32
Ubiquitin-like	PH domain-like	33	22
SH3-domain	SH3-domain	33	28
SH3-domain	SH2 domain	33	16
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	33	7
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	32	7
SH3-domain	BAR/IMD domain-like	31	12
Calcium ATPase, transduction domain A	HAD-like	31	7
Voltage-gated potassium channels	Voltage-gated potassium channels	30	9
Spermadhesin, CUB domain	Spermadhesin, CUB domain	30	25
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	29	3
Ubiquitin-like	Second domain of FERM	29	17
Homeodomain-like	Homeodomain-like	28	17
POZ domain	Voltage-gated potassium channels	28	4
SH2 domain	PH domain-like	27	21
PH domain-like	GTPase activation domain, GAP	27	22
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	27	20
Concanavalin A-like lectins/glucanases	EGF/Laminin	27	24
EF-hand	EF-hand	27	16
Spectrin repeat	Spectrin repeat	27	24
Thioredoxin-like	GST C-terminal domain-like	27	4
RING/U-box	RING/U-box	25	16
LDL receptor-like module	LDL receptor-like module	25	24
MHC antigen-recognition domain	Immunoglobulin	24	3
Cyclin-like	Cyclin-like	24	8
PDZ domain-like	PH domain-like	23	19
SH3-domain	Protein kinase-like (PK-like)	23	9
Protein kinase-like (PK-like)	Fibronectin type III	23	17
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	23	16
SH2 domain	Protein kinase-like (PK-like)	23	10
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	23	10
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	22	1
TNF receptor-like	TNF receptor-like	22	11
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	22	15
Immunoglobulin	Protein kinase-like (PK-like)	22	19
Protein kinase-like (PK-like)	PH domain-like	22	17
Ankyrin repeat	Ankyrin repeat	22	18
PH domain-like	(Phosphotyrosine protein) phosphatases II	21	10
ARM repeat	Protein kinase-like (PK-like)	21	16
FYVE/PHD zinc finger	FYVE/PHD zinc finger	21	13
lambda repressor-like DNA-binding domains	Homeodomain-like	20	9
E set domains	E set domains	20	14
Protein kinase-like (PK-like)	Cysteine-rich domain	20	15
Sema domain	Plexin repeat	20	11
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	19	15
PGBD-like	Metalloproteases ("zincins"), catalytic domain	18	5
L domain-like	Fibronectin type III	18	10
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	18	5
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	18	2
PH domain-like	EF-hand	18	11
PDZ domain-like	SH3-domain	18	14
ABC transporter transmembrane region	ABC transporter transmembrane region	18	4
SH3-domain	DBL homology domain (DH-domain)	18	11
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	18	8
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	18	5
Fibronectin type III	Concanavalin A-like lectins/glucanases	17	11
(Trans)glycosidases	Glycosyl hydrolase domain	17	9
WD40 repeat-like	WD40 repeat-like	17	14
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	17	13
Tudor/PWWP/MBT	Tudor/PWWP/MBT	17	14
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	17	5
Voltage-gated potassium channels	cAMP-binding domain-like	17	6
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	17	9
WW domain	WW domain	17	13
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	17	9
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	16	12
Retroviral matrix proteins	Retrovirus capsid protein, N-terminal core domain	16	2
GroEL apical domain-like	GroEL equatorial domain-like	16	5
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	16	13
Protein kinase-like (PK-like)	SAM/Pointed domain	16	8
PGBD-like	Hemopexin-like domain	16	4
Immunoglobulin	Concanavalin A-like lectins/glucanases	15	7
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	15	3
Integrin domains	Integrin domains	15	8
GroES-like	NAD(P)-binding Rossmann-fold domains	15	4
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	15	4
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	15	7
Thioredoxin-like	Thioredoxin-like	15	9
C-type lectin-like	C-type lectin-like	15	9
EF-hand	PLC-like phosphodiesterases	15	11
F-box domain	RNI-like	15	3
Retrovirus capsid dimerization domain-like	KRAB domain (Kruppel-associated box)	15	12
Integrin alpha N-terminal domain	Integrin domains	14	8
PH domain-like	Cysteine-rich domain	14	11
Tudor/PWWP/MBT	FYVE/PHD zinc finger	14	10
SH2 domain	SH2 domain	14	12
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	14	12
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	14	9
P-loop containing nucleoside triphosphate hydrolases	RNI-like	14	8
Myosin rod fragments	Myosin rod fragments	14	13
Voltage-gated potassium channels	E set domains	14	3
Ubiquitin-like	PDZ domain-like	13	10
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	13	11
RING/U-box	Cysteine proteinases	13	7
PH domain-like	ArfGap/RecO-like zinc finger	13	12
Ankyrin repeat	SOCS box-like	13	5
Cysteine-rich domain	Cysteine-rich domain	13	11
EGF/Laminin	Complement control module/SCR domain	13	11
Calponin-homology domain, CH-domain	Spectrin repeat	13	11
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	13	10
SRCR-like	SRCR-like	13	12
Periplasmic binding protein-like I	Periplasmic binding protein-like II	13	5
Kringle-like	Kringle-like	13	10
GTPase activation domain, GAP	SH3-domain	13	10
GroEL-intermediate domain like	GroEL apical domain-like	13	3
FYVE/PHD zinc finger	Bromodomain	13	11
vWA-like	vWA-like	12	12
ARM repeat	WD40 repeat-like	12	11
SAM/Pointed domain	SAM/Pointed domain	12	8
Ubiquitin-like	UBA-like	12	7
PH domain-like	PLC-like phosphodiesterases	12	8
dsRNA-binding domain-like	dsRNA-binding domain-like	12	8
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	12	8
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	12	9
Retroviral matrix proteins	Retrovirus zinc finger-like domains	12	1
GroEL-intermediate domain like	GroEL equatorial domain-like	12	2
Retrovirus capsid protein, N-terminal core domain	Retrovirus zinc finger-like domains	12	1
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	12	5
Galactose-binding domain-like	Protein kinase-like (PK-like)	12	6
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	11	10
Hormone receptor domain	Family A G protein-coupled receptor-like	11	5
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	11	3
SEA domain	Trypsin-like serine proteases	11	4
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	11	4
Ras GEF	Ubiquitin-like	11	9
L27 domain	PDZ domain-like	11	6
ARM repeat	Clathrin adaptor appendage domain	11	6
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	11	11
EGF/Laminin	YWTD domain	11	11
Galactose-binding domain-like	Fibronectin type III	11	6
EGF/Laminin	Spermadhesin, CUB domain	11	11
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	11	4
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	11	5
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	11	9
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	11	1
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	11	6
Kringle-like	Trypsin-like serine proteases	11	10
p53-like transcription factors	SH2 domain	11	4
Spermadhesin, CUB domain	LDL receptor-like module	11	9
Spectrin repeat	EF-hand	11	9
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	11	7
Chromo domain-like	Chromo domain-like	11	6
ARM repeat	Formin homology 2 domain (FH2 domain)	11	4
CCCH zinc finger	CCCH zinc finger	11	8
Snake toxin-like	Protein kinase-like (PK-like)	11	3
Trypsin-like serine proteases	Trypsin-like serine proteases	10	7
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	10	9
Ubiquitin-like	Ubiquitin-like	10	9
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	10	4
Nucleic acid-binding proteins	Nucleic acid-binding proteins	10	9
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	10	5
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	10	6
ArfGap/RecO-like zinc finger	Ankyrin repeat	10	7
Transcription factor STAT-4 N-domain	STAT	10	2
Growth factor receptor domain	Protein kinase-like (PK-like)	10	6
FnI-like domain	FnI-like domain	10	10
DEATH domain	P-loop containing nucleoside triphosphate hydrolases	10	6
Nucleotide cyclase	Nucleotide cyclase	10	4
L domain-like	Protein kinase-like (PK-like)	10	7
LDL receptor-like module	Trypsin-like serine proteases	10	7
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	10	4
vWA-like	Integrin domains	10	7
p53-like transcription factors	E set domains	10	4
Sema domain	Immunoglobulin	10	4
Ankyrin repeat	SAM/Pointed domain	10	8
Thiolase-like	Thiolase-like	10	3
RING/U-box	TRAF domain-like	10	9
PX domain	SH3-domain	10	6
Spermadhesin, CUB domain	Trypsin-like serine proteases	9	8
POZ domain	POZ domain	9	7
Fibronectin type III	SAM/Pointed domain	9	4
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	9	8
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	9	3
HMG-box	HMG-box	9	4
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	9	4
Ubiquitin-like	Protein kinase-like (PK-like)	9	7
TNF receptor-like	DEATH domain	9	4
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	9	6
Plexin repeat	Immunoglobulin	9	3
STAT	p53-like transcription factors	9	2
Ankyrin repeat	SH3-domain	9	7
L domain-like	Toll/Interleukin receptor TIR domain	9	9
SAM/Pointed domain	"Winged helix" DNA-binding domain	9	5
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	9	5
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	9	5
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	9	3
Growth factor receptor domain	Fibronectin type III	9	6
Growth factor receptor domain	TSP-1 type 1 repeat	9	7
C-type lectin-like	EGF/Laminin	9	9
Transcription factor STAT-4 N-domain	p53-like transcription factors	9	2
PAZ domain	Ribonuclease H-like	9	4
EGF/Laminin	Trypsin-like serine proteases	9	9
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	9	2
vWA-like	EGF/Laminin	9	7
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	9	2
LDL receptor-like module	EGF/Laminin	9	9
L domain-like	Growth factor receptor domain	9	7
Transcription factor STAT-4 N-domain	SH2 domain	9	2
Cadherin-like	Concanavalin A-like lectins/glucanases	9	6
F-box domain	WD40 repeat-like	8	2
TRAF domain-like	TRAF domain-like	8	8
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	8	5
PH domain-like	Ankyrin repeat	8	7
DEATH domain	Caspase-like	8	2
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	8	4
Actin depolymerizing proteins	Actin depolymerizing proteins	8	6
Doublecortin (DC)	Doublecortin (DC)	8	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	8	6
WW domain	PH domain-like	8	6
Galactose-binding domain-like	SAM/Pointed domain	8	3
Kazal-type serine protease inhibitors	EF-hand	8	7
EF-hand	RING/U-box	8	6
Sec7 domain	PH domain-like	8	3
F-box domain	Galactose-binding domain-like	8	1
Calponin-homology domain, CH-domain	EF-hand	8	5
SMAD/FHA domain	"Winged helix" DNA-binding domain	8	3
L domain-like	Family A G protein-coupled receptor-like	8	6
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	8	2
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	8	8
beta-beta-alpha zinc fingers	Homeodomain-like	8	7
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	8	7
Myosin rod fragments	Tropomyosin	8	7
L27 domain	SH3-domain	8	5
MFS general substrate transporter	Kazal-type serine protease inhibitors	8	5
Complement control module/SCR domain	Trypsin-like serine proteases	8	7
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	8	7
PH domain-like	Oxysterol-binding protein-like	8	4
BRCT domain	BRCT domain	8	7
Protease propeptides/inhibitors	Zn-dependent exopeptidases	8	1
TSP-1 type 1 repeat	Immunoglobulin	8	6
SMAD MH1 domain	SMAD/FHA domain	8	3
BAR/IMD domain-like	GTPase activation domain, GAP	8	5
DEATH domain	RNI-like	8	4
LDL receptor-like module	YWTD domain	8	8
SMAD/FHA domain	P-loop containing nucleoside triphosphate hydrolases	8	6
BAR/IMD domain-like	PH domain-like	8	6
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	8	8
Cysteine proteinases	EF-hand	8	3
STAT	SH2 domain	8	1
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	8	4
SET domain	beta-beta-alpha zinc fingers	8	7
L27 domain	P-loop containing nucleoside triphosphate hydrolases	8	5
Protease propeptides/inhibitors	Subtilisin-like	8	7
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	8	7
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	8	6
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	7	5
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	7	3
Galactose-binding domain-like	Growth factor receptor domain	7	4
(Trans)glycosidases	Galactose-binding domain-like	7	3
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	7	5
SH2 domain	SOCS box-like	7	2
PH domain-like	ARM repeat	7	7
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	7	5
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	7	6
SRCR-like	Trypsin-like serine proteases	7	5
Growth factor receptor domain	Kazal-type serine protease inhibitors	7	5
SAM/Pointed domain	PH domain-like	7	7
Ubiquitin-like	ARM repeat	7	6
PH domain-like	BEACH domain	7	6
LDL receptor-like module	SRCR-like	7	5
FYVE/PHD zinc finger	SET domain	7	6
cAMP-binding domain-like	cAMP-binding domain-like	7	5
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	7	6
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	7	6
TB module/8-cys domain	Growth factor receptor domain	7	7
Serine protease inhibitors	Serine protease inhibitors	7	7
FKBP-like	TPR-like	7	3
Calpain large subunit, middle domain (domain III)	EF-hand	7	2
Integrin alpha N-terminal domain	vWA-like	7	6
Galactose mutarotase-like	(Trans)glycosidases	7	6
ENV polyprotein, receptor-binding domain	Virus ectodomain	7	2
PH domain-like	FYVE/PHD zinc finger	7	5
Clc chloride channel	CBS-domain pair	7	2
Protein kinase-like (PK-like)	PDZ domain-like	7	5
TB module/8-cys domain	EGF/Laminin	7	7
Spermadhesin, CUB domain	Complement control module/SCR domain	7	6
ENTH/VHS domain	GAT-like domain	7	2
Cysteine proteinases	Transglutaminase, two C-terminal domains	7	3
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	7	3
WW domain	GTPase activation domain, GAP	7	6
Growth factor receptor domain	YWTD domain	7	7
Cullin homology domain	"Winged helix" DNA-binding domain	7	2
Fibronectin type III	vWA-like	6	6
Thyroglobulin type-1 domain	EF-hand	6	6
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	6	4
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	6	3
DUSP-like	Cysteine proteinases	6	4
Cysteine-rich domain	C2 domain (Calcium/lipid-binding domain, CaLB)	6	4
vWA-like	Integrin beta tail domain	6	4
Translation proteins	EF-G C-terminal domain-like	6	4
RING/U-box	Fibronectin type III	6	3
Flavoproteins	Riboflavin synthase domain-like	6	6
B-box zinc-binding domain	Fibronectin type III	6	3
FYVE/PHD zinc finger	Clavaminate synthase-like	6	4
DEATH domain	DEATH domain	6	3
EGF/Laminin	TSP type-3 repeat	6	5
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	6	5
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	6	3
Growth factor receptor domain	Spermadhesin, CUB domain	6	6
(Trans)glycosidases	Chitinase insertion domain	6	2
Cupredoxins	Cupredoxins	6	5
(Trans)glycosidases	(Trans)glycosidases	6	6
P-loop containing nucleoside triphosphate hydrolases	EF-hand	6	3
beta-sandwich domain of Sec23/24	vWA-like	6	4
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	6	4
C2 domain (Calcium/lipid-binding domain, CaLB)	SH2 domain	6	6
Sema domain	E set domains	6	6
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	6	3
GAF domain-like	HD-domain/PDEase-like	6	4
YWTD domain	YWTD domain	6	6
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	6	3
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	6	1
PA domain	Zn-dependent exopeptidases	6	2
CoA-dependent acyltransferases	CoA-dependent acyltransferases	6	1
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	6	2
Cullin repeat-like	Cullin homology domain	6	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	6	4
EF-hand	SH2 domain	6	4
TB module/8-cys domain	TB module/8-cys domain	6	6
Galactose mutarotase-like	Glycosyl hydrolase domain	6	5
EF-hand	Cysteine-rich domain	6	4
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	6	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	6	5
Cysteine-rich domain	GTPase activation domain, GAP	6	4
E set domains	Transglutaminase, two C-terminal domains	6	2
WWE domain	ADP-ribosylation	6	3
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	6	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	6	4
E set domains	Cysteine proteinases	6	2
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	6	2
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	6	3
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	6	2
GAF domain-like	GAF domain-like	6	4
EGF/Laminin	Integrin beta tail domain	6	4
Regulator of G-protein signaling, RGS	PH domain-like	6	5
vWA-like	Helical domain of Sec23/24	6	4
NTF2-like	RNA-binding domain, RBD	6	3
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	6	5
Concanavalin A-like lectins/glucanases	TSP type-3 repeat	6	5
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	6	2
Immunoglobulin	Toll/Interleukin receptor TIR domain	6	4
Plexin repeat	E set domains	6	6
C-type lectin-like	Complement control module/SCR domain	6	6
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	6	4
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	6	3
BPTI-like	BPTI-like	6	6
EGF/Laminin	Fibronectin type III	6	6
GroES-like	GroES-like	6	1
Growth factor receptor domain	Concanavalin A-like lectins/glucanases	6	6
E set domains	Terpenoid cyclases/Protein prenyltransferases	6	4
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	6	4
Bromodomain	Bromodomain	6	5
TSP type-3 repeat	TSP type-3 repeat	6	5
PDZ domain-like	Glucocorticoid receptor-like (DNA-binding domain)	6	5
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	4
Smc hinge domain	P-loop containing nucleoside triphosphate hydrolases	6	5
Galactose-binding domain-like	Galactose-binding domain-like	6	5
Intermediate filament protein, coiled coil region	Prefoldin	5	3
Kazal-type serine protease inhibitors	Thyroglobulin type-1 domain	5	5
PH domain-like	Ras GEF	5	5
Integrin domains	Integrin beta tail domain	5	3
ADC-like	P-loop containing nucleoside triphosphate hydrolases	5	3
Immunoglobulin	C-type lectin-like	5	4
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	5	3
SH3-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	5	5
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	5	3
Cystatin/monellin	Cystatin/monellin	5	5
E set domains	Alpha-macroglobulin receptor domain	5	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	5	4
Plexin repeat	Integrin beta tail domain	5	3
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	5	5
lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	5	5
Ubiquitin-like	Cysteine proteinases	5	3
FnI-like domain	Growth factor receptor domain	5	4
CCCH zinc finger	RING/U-box	5	4
Kazal-type serine protease inhibitors	Trypsin-like serine proteases	5	5
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	5	3
Calponin-homology domain, CH-domain	GAS2 domain-like	5	4
LDL receptor-like module	Growth factor receptor domain	5	5
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	5	2
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	5	4
Peptidylarginine deiminase Pad4, middle domain	Pentein	5	1
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	5	4
Cupredoxins	Pentein	5	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	5	3
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	5	4
SH3-domain	SAM/Pointed domain	5	4
ClpP/crotonase	ClpP/crotonase	5	4
EGF/Laminin	Kazal-type serine protease inhibitors	5	4
Enolase N-terminal domain-like	Enolase C-terminal domain-like	5	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	5	3
Ankyrin repeat	POZ domain	5	5
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	5	4
Translation proteins	Ribosomal protein S5 domain 2-like	5	3
Spectrin repeat	Plakin repeat	5	5
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	5	5
Serine protease inhibitors	FnI-like domain	5	5
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	5	3
WW domain	Hect, E3 ligase catalytic domain	5	3
Subtilisin-like	Galactose-binding domain-like	5	4
RING/U-box	TPR-like	5	3
ARM repeat	Subdomain of clathrin and coatomer appendage domain	5	2
FnI-like domain	TSP-1 type 1 repeat	5	3
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	5	5
(Phosphotyrosine protein) phosphatases II	SH2 domain	5	3
Ankyrin repeat	DEATH domain	5	4
PA domain	Transferrin receptor-like dimerisation domain	5	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	5	1
"Winged helix" DNA-binding domain	PDZ domain-like	5	4
RING/U-box	E set domains	5	5
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	5	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	5	3
Plexin repeat	vWA-like	5	3
RING/U-box	WD40 repeat-like	5	5
Ankyrin repeat	TPR-like	5	4
Plexin repeat	EGF/Laminin	5	3
E set domains	GTPase activation domain, GAP	5	5
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	5	5
UBA-like	RNA-binding domain, RBD	5	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	5	3
PA domain	RING/U-box	5	2
Cullin repeat-like	"Winged helix" DNA-binding domain	5	1
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	5	4
Elafin-like	Elafin-like	5	4
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	5	4
GTPase activation domain, GAP	SH2 domain	5	5
Trypsin-like serine proteases	PDZ domain-like	5	5
ARM repeat	RING/U-box	5	5
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	2
Integrin domains	EGF/Laminin	5	3
Cupredoxins	Peptidylarginine deiminase Pad4, middle domain	5	1
Ribonuclease H-like	DNA/RNA polymerases	5	3
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	5	3
RNI-like	L domain-like	5	4
Protein kinase-like (PK-like)	KA1-like	5	2
Growth factor receptor domain	Thyroglobulin type-1 domain	5	2
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	5	4
Serum albumin-like	Serum albumin-like	5	2
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	5	1
RNI-like	RNI-like	5	4
GLA-domain	Trypsin-like serine proteases	5	5
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	5	4
Kelch motif	Kelch motif	5	4
Sema domain	GTPase activation domain, GAP	5	5
Protease propeptides/inhibitors	Galactose-binding domain-like	5	4
Protein kinase-like (PK-like)	Nucleotide cyclase	5	4
PX domain	BAR/IMD domain-like	5	2
PDZ domain-like	DBL homology domain (DH-domain)	5	5
PH domain-like	Moesin tail domain	5	3
SAM/Pointed domain	GTPase activation domain, GAP	5	5
Protein kinase-like (PK-like)	Polo-box domain	5	4
Phospholipase D/nuclease	Phospholipase D/nuclease	5	4
Second domain of FERM	PDZ domain-like	5	3
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	5	4
PH domain-like	WD40 repeat-like	5	5
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	5	2
Ubiquitin-like	PX domain	4	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	2
CAD & PB1 domains	Protein kinase-like (PK-like)	4	2
N-terminal domain of cbl (N-cbl)	SH2 domain	4	2
Immunoglobulin	Growth factor receptor domain	4	2
Polo-box domain	Polo-box domain	4	3
SAND domain-like	FYVE/PHD zinc finger	4	3
BAR/IMD domain-like	Ankyrin repeat	4	3
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	4	3
Somatomedin B domain	Somatomedin B domain	4	4
B-box zinc-binding domain	E set domains	4	4
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	4	2
SH3-domain	Fibronectin type III	4	4
Sec63 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	4	3
Ras GEF	Cysteine-rich domain	4	2
PDZ domain-like	SAM/Pointed domain	4	4
Hairpin loop containing domain-like	Trypsin-like serine proteases	4	3
SNARE-like	SNARE fusion complex	4	2
Fibrinogen coiled-coil and central regions	Fibrinogen C-terminal domain-like	4	2
Surp module (SWAP domain)	Surp module (SWAP domain)	4	2
FKBP-like	FKBP-like	4	3
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	4	3
PH domain-like	"Winged helix" DNA-binding domain	4	3
Rap/Ran-GAP	PDZ domain-like	4	2
Metalloproteases ("zincins"), catalytic domain	ARM repeat	4	3
Arginase/deacetylase	Arginase/deacetylase	4	2
Voltage-gated potassium channels	Small-conductance potassium channel	4	2
RING/U-box	UBA-like	4	4
L domain-like	WD40 repeat-like	4	4
SEA domain	LDL receptor-like module	4	3
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	4	2
Calponin-homology domain, CH-domain	PH domain-like	4	4
RNA-binding domain, RBD	Ran binding protein zinc finger-like	4	4
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	4	3
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	4	4
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	4	3
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	4	1
Tudor/PWWP/MBT	SAM/Pointed domain	4	4
DBL homology domain (DH-domain)	Ras GEF	4	4
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	4	2
EF-hand	Mitochondrial carrier	4	2
PurM N-terminal domain-like	PurM C-terminal domain-like	4	3
N-terminal domain of cbl (N-cbl)	EF-hand	4	2
Frizzled cysteine-rich domain	TIMP-like	4	1
SNARE fusion complex	SNARE fusion complex	4	2
P-loop containing nucleoside triphosphate hydrolases	Protein kinase-like (PK-like)	4	4
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	4	2
PH domain-like	C-terminal domain of PLC-beta	4	2
EF-hand	C-terminal domain of PLC-beta	4	2
Voltage-gated potassium channels	Periplasmic binding protein-like II	4	2
Spermadhesin, CUB domain	C-type lectin-like	4	3
Protein kinase-like (PK-like)	DEATH domain	4	4
P-loop containing nucleoside triphosphate hydrolases	POZ domain	4	2
Colipase-like	Colipase-like	4	1
Periplasmic binding protein-like I	Nucleotide cyclase	4	3
RING/U-box	NHL repeat	4	3
Formyltransferase	FMT C-terminal domain-like	4	3
SH2 domain	RING/U-box	4	2
N-terminal domain of cbl (N-cbl)	RING/U-box	4	2
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	4	3
Concanavalin A-like lectins/glucanases	ARM repeat	4	4
PKD domain	PKD domain	4	4
PAH2 domain	PAH2 domain	4	3
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	4	4
HCP-like	HCP-like	4	4
Ubiquitin-like	Thioredoxin-like	4	3
PYP-like sensor domain (PAS domain)	Nuclear receptor coactivator interlocking domain	4	2
Plakin repeat	Plakin repeat	4	4
SH3-domain	EF-hand	4	4
CalX-like	CalX-like	4	3
L domain-like	Calponin-homology domain, CH-domain	4	2
Snake toxin-like	Snake toxin-like	4	4
ADC-like	Cdc48 domain 2-like	4	2
Ras GEF	EF-hand	4	2
Growth factor receptor domain	SAM/Pointed domain	4	2
Protein kinase-like (PK-like)	PX domain	4	3
NTF2-like	UBA-like	4	1
cAMP-binding domain-like	Ubiquitin-like	4	4
Ubiquitin-like	Cysteine-rich domain	4	3
PHM/PNGase F	PHM/PNGase F	4	2
Periplasmic binding protein-like I	Voltage-gated potassium channels	4	2
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	4	2
FAS1 domain	FAS1 domain	4	4
Protein kinase-like (PK-like)	Ankyrin repeat	4	4
Zn-finger domain of Sec23/24	vWA-like	4	2
CBS-domain pair	CBS-domain pair	4	2
SH3-domain	WW domain	4	3
RUN domain-like	FYVE/PHD zinc finger	4	3
ARM repeat	TPR-like	4	3
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	3
Pectin lyase-like	Pectin lyase-like	4	4
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	4	2
Actin-crosslinking proteins	Actin-crosslinking proteins	4	1
RING/U-box	Homeodomain-like	4	3
MFS general substrate transporter	MFS general substrate transporter	4	3
FF domain	FF domain	4	3
FYVE/PHD zinc finger	RING/U-box	4	4
C2 domain (Calcium/lipid-binding domain, CaLB)	FabD/lysophospholipase-like	4	3
Periplasmic binding protein-like II	Periplasmic binding protein-like II	4	1
TPR-like	SH3-domain	4	4
SAP domain	RNA-binding domain, RBD	4	2
L domain-like	EGF/Laminin	4	4
TGS-like	ThrRS/AlaRS common domain	4	3
RNI-like	Toll/Interleukin receptor TIR domain	4	4
cAMP-binding domain-like	Ras GEF	4	4
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	4	4
PreATP-grasp domain	Rudiment single hybrid motif	4	4
L domain-like	NTF2-like	4	1
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	4	2
RNA-binding domain, RBD	L domain-like	4	1
Rudiment single hybrid motif	Single hybrid motif	4	4
BEACH domain	WD40 repeat-like	4	4
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	4	3
Alpha-macroglobulin receptor domain	TIMP-like	4	3
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	4	1
GTPase activation domain, GAP	Bet v1-like	4	3
Galactose-binding domain-like	Concanavalin A-like lectins/glucanases	4	3
PLP-binding barrel	Alanine racemase C-terminal domain-like	4	3
FYVE/PHD zinc finger	RNI-like	4	2
PsbU/PolX domain-like	Nucleotidyltransferase	4	3
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	4	2
Nucleotidyltransferase	Nucleotidyltransferase	4	3
Midkine	Midkine	4	2
Immunoglobulin	(Phosphotyrosine protein) phosphatases II	4	3
Hairpin loop containing domain-like	Kringle-like	4	3
vWA-like	Concanavalin A-like lectins/glucanases	4	4
TATA-box binding protein-like	TATA-box binding protein-like	4	2
EGF/Laminin	TIMP-like	4	2
RING/U-box	Ankyrin repeat	4	3
Actin depolymerizing proteins	VHP, Villin headpiece domain	4	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	4	3
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	4	3
HCP-like	TPR-like	4	4
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	4	1
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	4	4
Second domain of FERM	Moesin tail domain	4	2
BRCT domain	Homeodomain-like	4	2
Kazal-type serine protease inhibitors	Immunoglobulin	4	2
GLA-domain	EGF/Laminin	4	4
Plexin repeat	Integrin domains	4	2
L domain-like	UBA-like	4	1
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	4	2
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	4	4
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	4	2
"Winged helix" DNA-binding domain	Ubiquitin-like	4	3
Folate-binding domain	Aminomethyltransferase beta-barrel domain	4	4
Single hybrid motif	CoA-dependent acyltransferases	4	3
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	4	4
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	3
PAP/OAS1 substrate-binding domain	PAP/OAS1 substrate-binding domain	4	3
Concanavalin A-like lectins/glucanases	Metalloproteases ("zincins"), catalytic domain	4	4
TSP-1 type 1 repeat	LDL receptor-like module	4	4
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	4	2
Terpenoid cyclases/Protein prenyltransferases	TIMP-like	3	2
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	3	1
Concanavalin A-like lectins/glucanases	Fibrinogen C-terminal domain-like	3	2
Concanavalin A-like lectins/glucanases	Complement control module/SCR domain	3	3
ENTH/VHS domain	SH3-domain	3	2
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	1
Assembly domain of cartilage oligomeric matrix protein	TSP type-3 repeat	3	3
TAFH domain-like	HIT/MYND zinc finger-like	3	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	3	3
PH domain-like	NAD kinase/diacylglycerol kinase-like	3	3
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	3	3
Triple coiled coil domain of C-type lectins	C-type lectin-like	3	1
EF-hand	Riboflavin synthase domain-like	3	2
(Trans)glycosidases	Trefoil	3	3
RCC1/BLIP-II	POZ domain	3	2
B-box zinc-binding domain	NHL repeat	3	2
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	3	3
SH3-domain	PLC-like phosphodiesterases	3	3
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	3	3
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	3	2
Galactose mutarotase-like	Trefoil	3	3
Ubiquitin-like	SH3-domain	3	3
EGF/Laminin	Fibrinogen C-terminal domain-like	3	2
Ubiquitin-like	SH2 domain	3	2
AN1-like Zinc finger	AN1-like Zinc finger	3	2
Somatomedin B domain	Hemopexin-like domain	3	2
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	3	1
C2 domain (Calcium/lipid-binding domain, CaLB)	PX domain	3	2
ArfGap/RecO-like zinc finger	GTPase activation domain, GAP	3	3
ARM repeat	PX domain	3	2
Assembly domain of cartilage oligomeric matrix protein	EGF/Laminin	3	3
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	3	1
Tex N-terminal region-like	RuvA domain 2-like	3	3
GST C-terminal domain-like	Nucleotidylyl transferase	3	3
Immunoglobulin	Complement control module/SCR domain	3	3
TSP-1 type 1 repeat	DEATH domain	3	2
Galactose-binding domain-like	EGF/Laminin	3	3
ARM repeat	Galactose-binding domain-like	3	3
FMT C-terminal domain-like	ALDH-like	3	2
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	3	2
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	3	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	3	3
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	3	1
Glycosyl hydrolase domain	Trefoil	3	3
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	3	2
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Bromodomain	Tudor/PWWP/MBT	3	3
Macro domain-like	ADP-ribosylation	3	3
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	3	1
C-terminal, gelsolin-like domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	2
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	3	2
Activator of Hsp90 ATPase, Aha1	Bet v1-like	3	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	3	3
Macro domain-like	Macro domain-like	3	3
Spermadhesin, CUB domain	Galactose-binding domain-like	3	2
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	3	3
Tex N-terminal region-like	Ribonuclease H-like	3	3
RNA-binding domain, RBD	PABC (PABP) domain	3	1
Growth factor receptor domain	Trypsin-like serine proteases	3	3
RUN domain-like	SH3-domain	3	2
Ribonuclease H-like	RuvA domain 2-like	3	3
TIMP-like	Kazal-type serine protease inhibitors	3	3
Phenylalanine zipper	SH2 domain	3	2
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	3	1
HR1 repeat	HR1 repeat	3	2
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	1
Somatomedin B domain	Alkaline phosphatase-like	3	3
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	3	2
Cap-Gly domain	Cap-Gly domain	3	3
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	3	2
Kringle-like	EGF/Laminin	3	3
WGR domain-like	ADP-ribosylation	3	2
vWA-like	Growth factor receptor domain	3	3
Kazal-type serine protease inhibitors	PDZ domain-like	3	3
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	3	3
Galactose oxidase, central domain	Kelch motif	3	3
Second domain of FERM	Protein kinase-like (PK-like)	3	3
L domain-like	Concanavalin A-like lectins/glucanases	3	3
Regulator of G-protein signaling, RGS	PX domain	3	2
EGF/Laminin	EF-hand	3	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	3	1
Complement control module/SCR domain	vWA-like	3	3
Amine oxidase N-terminal region	Amine oxidase N-terminal region	3	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
DNase I-like	GTPase activation domain, GAP	3	1
Chaperone J-domain	Homeodomain-like	3	3
RNA-binding domain, RBD	dsRNA-binding domain-like	3	2
Nitric oxide (NO) synthase oxygenase domain	Flavoproteins	3	3
BRCT domain	PsbU/PolX domain-like	3	2
Kelch motif	EGF/Laminin	3	3
ARID-like	Clavaminate synthase-like	3	2
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	3	1
PreATP-grasp domain	Single hybrid motif	3	3
PDZ domain-like	Regulator of G-protein signaling, RGS	3	3
Second domain of FERM	Second domain of FERM	3	2
BPTI-like	Immunoglobulin	3	3
Sec63 N-terminal domain-like	E set domains	3	3
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	3	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	3	3
Saposin	Saposin	3	3
Ubiquitin-like	SMAD/FHA domain	3	3
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	3	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	3	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	3	3
Putative DNA-binding domain	SAND domain-like	3	2
SAP domain	Concanavalin A-like lectins/glucanases	3	3
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	3	2
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	3	1
TGS-like	Class II aaRS and biotin synthetases	3	2
PAP/OAS1 substrate-binding domain	Retrovirus zinc finger-like domains	3	2
Plexin repeat	GTPase activation domain, GAP	3	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	3	2
Glucocorticoid receptor-like (DNA-binding domain)	VHP, Villin headpiece domain	3	2
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	3	3
Protein kinase-like (PK-like)	RCC1/BLIP-II	3	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	3	2
t-snare proteins	SNARE fusion complex	3	2
Galactose-binding domain-like	Zn-dependent exopeptidases	3	2
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	3	3
WD40 repeat-like	EF-hand	3	3
Class I glutamine amidotransferase-like	PreATP-grasp domain	3	3
Cysteine-rich domain	SH3-domain	3	2
EGF/Laminin	Heme-dependent peroxidases	3	2
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	3	1
ARM repeat	Sec7 domain	3	2
Smc hinge domain	Tropomyosin	3	3
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	3	3
Concanavalin A-like lectins/glucanases	FnI-like domain	3	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	3	1
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	3	3
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	3	3
Concanavalin A-like lectins/glucanases	P-loop containing nucleoside triphosphate hydrolases	3	3
Tudor/PWWP/MBT	SET domain	3	2
SAND domain-like	Bromodomain	3	2
ThrRS/AlaRS common domain	Class II aaRS ABD-related	3	2
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	3	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	3	3
Phosphofructokinase	Phosphofructokinase	3	1
L domain-like	P-loop containing nucleoside triphosphate hydrolases	3	3
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	3	1
(Trans)glycosidases	Invertebrate chitin-binding proteins	3	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	3	1
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	3	3
C-type lectin-like	Growth factor receptor domain	3	3
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	3	1
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	3	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	3	3
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	3	1
Eukaryotic type KH-domain (KH-domain type I)	RING/U-box	3	2
Protein kinase-like (PK-like)	WD40 repeat-like	3	3
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	3	3
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	3	1
Anaphylotoxins (complement system)	TIMP-like	3	2
MgtE membrane domain-like	MgtE membrane domain-like	3	2
Anaphylotoxins (complement system)	Terpenoid cyclases/Protein prenyltransferases	3	2
PriA/YqbF domain	GINS helical bundle-like	3	2
P-loop containing nucleoside triphosphate hydrolases	SOCS box-like	3	1
TGS-like	Class II aaRS ABD-related	3	2
Mib/herc2 domain-like	Ankyrin repeat	3	2
EF-hand	NAD kinase/diacylglycerol kinase-like	3	3
Concanavalin A-like lectins/glucanases	WD40 repeat-like	3	3
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	3	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	3	3
Ypt/Rab-GAP domain of gyp1p	EF-hand	3	1
Phenylalanine zipper	PH domain-like	3	2
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	3	1
Eukaryotic type KH-domain (KH-domain type I)	Nucleic acid-binding proteins	3	2
Immunoglobulin	DEATH domain	3	2
SH2 domain	PLC-like phosphodiesterases	3	3
Calponin-homology domain, CH-domain	PRC-barrel domain	3	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	3	2
HLH, helix-loop-helix DNA-binding domain	Nuclear receptor coactivator interlocking domain	3	1
Ricin B-like lectins	C-type lectin-like	3	2
Ubiquitin-like	Ankyrin repeat	3	3
Ricin B-like lectins	Kringle-like	3	2
GFP-like	Growth factor receptor domain	3	3
Somatomedin B domain	His-Me finger endonucleases	3	3
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	3	1
FYVE/PHD zinc finger	HMG-box	3	3
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	3
Formyltransferase	ALDH-like	3	2
RUN domain-like	Ypt/Rab-GAP domain of gyp1p	3	2
WW domain	FF domain	3	2
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	3	2
Nucleic acid-binding proteins	Translation proteins SH3-like domain	3	2
FYVE/PHD zinc finger	Chromo domain-like	3	2
WW domain	EF-hand	3	3
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	3	3
Protein kinase-like (PK-like)	MIT domain	3	3
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	3	3
Ubiquitin-like	Moesin tail domain	3	1
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	3	2
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	3	3
Ankyrin repeat	HIT/MYND zinc finger-like	3	2
PR-1-like	Crisp domain-like	3	1
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	3	1
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	3	3
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	3	3
SAM/Pointed domain	ArfGap/RecO-like zinc finger	3	3
Glucocorticoid receptor-like (DNA-binding domain)	beta-beta-alpha zinc fingers	3	1
Galactose-binding domain-like	Carboxypeptidase regulatory domain-like	3	2
BRCT domain	DNA polymerase beta, N-terminal domain-like	3	2
DBL homology domain (DH-domain)	BAR/IMD domain-like	3	2
B-box zinc-binding domain	FYVE/PHD zinc finger	3	2
UBA-like	Cysteine proteinases	3	3
Concanavalin A-like lectins/glucanases	Assembly domain of cartilage oligomeric matrix protein	3	3
UBA-like	UBA-like	3	3
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	3	2
SH3-domain	CAD & PB1 domains	3	3
ENTH/VHS domain	RNA-binding domain, RBD	3	3
CRAL/TRIO domain	Spectrin repeat	3	3
Ribosomal L27 protein-like	Nucleic acid-binding proteins	3	2
Anaphylotoxins (complement system)	Alpha-macroglobulin receptor domain	3	2
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	3	3
CCCH zinc finger	beta-beta-alpha zinc fingers	3	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	3	1
Alkaline phosphatase-like	His-Me finger endonucleases	3	3
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	3	1
Tudor/PWWP/MBT	Staphylococcal nuclease	3	3
FnI-like domain	EGF/Laminin	3	2
Nucleotidyltransferase	Retrovirus zinc finger-like domains	3	2
Chitinase insertion domain	Invertebrate chitin-binding proteins	3	1
SEA domain	Spermadhesin, CUB domain	3	2
FYVE/PHD zinc finger	"Winged helix" DNA-binding domain	3	3
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	3	2
ARM repeat	Hect, E3 ligase catalytic domain	3	3
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	3	3
Hedgehog/DD-peptidase	Hedgehog/intein (Hint) domain	3	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	3	2
Complement control module/SCR domain	Fibronectin type III	3	3
WWE domain	RING/U-box	3	3
Spectrin repeat	PH domain-like	3	3
Elafin-like	BPTI-like	3	3
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	3	2
Nitric oxide (NO) synthase oxygenase domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	3
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	3	3
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	3	1
Formin homology 2 domain (FH2 domain)	Cyclin-like	3	3
Phospholipase A2, PLA2	Phospholipase A2, PLA2	3	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	3	3
ARM repeat	"Winged helix" DNA-binding domain	3	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
Fibronectin type III	Fibrinogen C-terminal domain-like	3	3
PUA domain-like	RING/U-box	3	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	3	2
KRAB domain (Kruppel-associated box)	KRAB domain (Kruppel-associated box)	3	3
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	3	1
GTF2I-like repeat	GTF2I-like repeat	3	3
BRCT domain	Nucleotidyltransferase	3	2
Protein kinase-like (PK-like)	NTF2-like	3	1
Ribonuclease H-like	RNA-binding domain, RBD	3	3
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	3	3
Spermadhesin, CUB domain	Kelch motif	3	3
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	3	2
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	3	3
SH2 domain	Ras GEF	3	2
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	3	1
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	3	2
Nitric oxide (NO) synthase oxygenase domain	Riboflavin synthase domain-like	3	3
Amine oxidase N-terminal region	Amine oxidase catalytic domain	3	2
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	3	2
MFS general substrate transporter	Pentapeptide repeat-like	2	1
RING/U-box	Trimerization domain of TRAF	2	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	2	2
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
IP3 receptor type 1 binding core, domain 2	EF-hand	2	2
gamma-Crystallin-like	gamma-Crystallin-like	2	2
Fibronectin type III	BPTI-like	2	2
SMAD/FHA domain	BRCT domain	2	2
Metalloproteases ("zincins"), catalytic domain	Complement control module/SCR domain	2	2
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	2	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	2	2
FAD/NAD(P)-binding domain	Glucocorticoid receptor-like (DNA-binding domain)	2	2
PH domain-like	Tropomyosin	2	1
Cytochrome b5-like heme/steroid binding domain	E set domains	2	1
Calponin-homology domain, CH-domain	Plakin repeat	2	2
CCCH zinc finger	Retrovirus zinc finger-like domains	2	2
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	2	2
TSP-1 type 1 repeat	Complement control module/SCR domain	2	2
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	2	2
Mannose 6-phosphate receptor domain	Kringle-like	2	2
B-box zinc-binding domain	Bromodomain	2	1
Ankyrin repeat	Cap-Gly domain	2	2
L domain-like	FnI-like domain	2	2
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	2	1
DNA-binding domain	FYVE/PHD zinc finger	2	2
RCC1/BLIP-II	RCC1/BLIP-II	2	2
Chromo domain-like	BRK domain-like	2	2
EGF/Laminin	Notch domain	2	2
Galactose-binding domain-like	Cullin homology domain	2	2
Metalloproteases ("zincins"), catalytic domain	TRAF domain-like	2	2
CCCH zinc finger	P-loop containing nucleoside triphosphate hydrolases	2	2
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	2	2
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	2	2
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	2	2
LCCL domain	LCCL domain	2	1
ARM repeat	WWE domain	2	2
Nucleotide cyclase	P-loop containing nucleoside triphosphate hydrolases	2	1
RING/U-box	BRCT domain	2	2
ARM repeat	Cullin homology domain	2	2
Chaperone J-domain	Nucleotidyltransferase substrate binding subunit/domain	2	2
P-loop containing nucleoside triphosphate hydrolases	TGS-like	2	1
BAR/IMD domain-like	SH2 domain	2	2
WD40 repeat-like	SOCS box-like	2	2
Kelch motif	C-type lectin-like	2	2
MIT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
DEATH domain	B-box zinc-binding domain	2	1
Metallo-dependent phosphatases	EF-hand	2	1
Homeodomain-like	FAD/NAD(P)-binding domain	2	2
POZ domain	A DNA-binding domain in eukaryotic transcription factors	2	2
ARM repeat	Cysteine proteinases	2	2
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	2	1
Heme-dependent peroxidases	FnI-like domain	2	2
Thioredoxin-like	Six-hairpin glycosidases	2	1
RING/U-box	DUSP-like	2	1
Ankyrin repeat	Fibronectin type III	2	2
Immunoglobulin	Family A G protein-coupled receptor-like	2	2
Bromodomain	RING/U-box	2	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	2	2
P-loop containing nucleoside triphosphate hydrolases	TPR-like	2	1
Concanavalin A-like lectins/glucanases	PH domain-like	2	2
vWA-like	Chicken cartilage matrix protein	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	2
p53-like transcription factors	p53 tetramerization domain	2	2
Notch domain	Notch domain	2	2
TAZ domain	RING/U-box	2	1
Subtilisin-like	Growth factor receptor domain	2	1
ClpS-like	"Winged helix" DNA-binding domain	2	1
Surp module (SWAP domain)	Ubiquitin-like	2	1
Ankyrin repeat	ARM repeat	2	2
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	2	2
FAS1 domain	EGF/Laminin	2	2
LDL receptor-like module	Frizzled cysteine-rich domain	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	2	1
ARM repeat	BEACH domain	2	2
LDL receptor-like module	Concanavalin A-like lectins/glucanases	2	2
Concanavalin A-like lectins/glucanases	SOCS box-like	2	1
SET domain	TPR-like	2	2
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	2	1
TSP-1 type 1 repeat	EGF/Laminin	2	1
tRNA-binding arm	Class II aaRS and biotin synthetases	2	2
cAMP-binding domain-like	PDZ domain-like	2	2
RUN domain-like	RUN domain-like	2	2
Homeodomain-like	FAD-linked reductases, C-terminal domain	2	2
DEK C-terminal domain	(Phosphotyrosine protein) phosphatases II	2	1
"Winged helix" DNA-binding domain	occludin/ELL-like	2	1
Ribonuclease H-like	HRDC-like	2	2
ARID-like	FYVE/PHD zinc finger	2	1
CRAL/TRIO domain	PH domain-like	2	2
Class II aaRS and biotin synthetases	Translation proteins	2	1
Histone-fold	Histone-fold	2	2
Concanavalin A-like lectins/glucanases	Family A G protein-coupled receptor-like	2	2
Nucleotide-diphospho-sugar transferases	ARM repeat	2	1
TRAF domain-like	F-box domain	2	2
Growth factor receptor domain	Ankyrin repeat	2	2
Zn-dependent exopeptidases	Zn-dependent exopeptidases	2	2
Notch domain	Ankyrin repeat	2	2
WD40 repeat-like	Bromodomain	2	2
Translation proteins	Initiation factor IF2/eIF5b, domain 3	2	2
A middle domain of Talin 1	I/LWEQ domain	2	2
beta-lactamase/transpeptidase-like	Ankyrin repeat	2	1
Plakin repeat	GAS2 domain-like	2	2
Oligoxyloglucan reducing end-specific cellobiohydrolase	PKD domain	2	2
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	2	2
Cadherin-like	EGF/Laminin	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	2
Calponin-homology domain, CH-domain	WW domain	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Chaperone J-domain	2	1
WD40 repeat-like	Tricorn protease domain 2	2	2
PDZ domain-like	GTPase activation domain, GAP	2	2
WW domain	FKBP-like	2	1
Nucleic acid-binding proteins	BRCT domain	2	2
"Winged helix" DNA-binding domain	Ras GEF	2	2
WWE domain	WWE domain	2	2
Translational machinery components	L30e-like	2	2
N-acetylmuramoyl-L-alanine amidase-like	N-acetylmuramoyl-L-alanine amidase-like	2	1
Plakin repeat	EF-hand	2	2
EF-hand	Myosin rod fragments	2	1
RNA-binding domain, RBD	Cyclophilin-like	2	2
Oxidoreductase molybdopterin-binding domain	E set domains	2	1
DPP6 N-terminal domain-like	WD40 repeat-like	2	2
RNI-like	ARM repeat	2	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	2	2
FKBP-like	EF-hand	2	1
Ankyrin repeat	PDZ domain-like	2	2
Sema domain	TSP-1 type 1 repeat	2	2
CRAL/TRIO domain	DBL homology domain (DH-domain)	2	2
Surp module (SWAP domain)	ENTH/VHS domain	2	2
HMG-box	SET domain	2	2
Ubiquitin-like	GTPase activation domain, GAP	2	2
Spectrin repeat	GAS2 domain-like	2	2
Concanavalin A-like lectins/glucanases	EF-hand	2	2
BAR/IMD domain-like	Cysteine-rich domain	2	1
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	2	1
Kringle-like	Hemopexin-like domain	2	1
IP3 receptor type 1 binding core, domain 2	Concanavalin A-like lectins/glucanases	2	2
Calponin-homology domain, CH-domain	SH2 domain	2	2
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	2	2
DUSP-like	Ubiquitin-like	2	2
Spermadhesin, CUB domain	SRCR-like	2	2
HIT/MYND zinc finger-like	Tudor/PWWP/MBT	2	2
Dimerization cofactor of HNF-1 alpha	Homeodomain-like	2	2
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	2	2
Tudor/PWWP/MBT	ARM repeat	2	2
RNase III domain-like	dsRNA-binding domain-like	2	2
PR-1-like	LCCL domain	2	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	2	2
ARID-like	Chromo domain-like	2	1
PX domain	MIT domain	2	1
SEA domain	SEA domain	2	2
TSP-1 type 1 repeat	BPTI-like	2	2
TRAF domain-like	POZ domain	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
WW domain	RING/U-box	2	2
UBA-like	Phosphoglycerate mutase-like	2	1
PGBD-like	Kringle-like	2	1
HIT/MYND zinc finger-like	TPR-like	2	2
Histone-fold	DBL homology domain (DH-domain)	2	2
FYVE/PHD zinc finger	PUA domain-like	2	2
TSP-1 type 1 repeat	TSP type-3 repeat	2	1
Protein kinase-like (PK-like)	G protein-binding domain	2	2
Second domain of FERM	SH3-domain	2	2
"Winged helix" DNA-binding domain	HRDC-like	2	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	2	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	2	2
TAZ domain	Nuclear receptor coactivator interlocking domain	2	1
Ubiquitin-like	RING/U-box	2	2
Kelch motif	Fibronectin type III	2	2
Complement control module/SCR domain	Growth factor receptor domain	2	2
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	2	2
Trimeric LpxA-like enzymes	ARM repeat	2	1
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	2	1
Ubiquitin-like	DBL homology domain (DH-domain)	2	2
RNA-binding domain, RBD	SET domain	2	1
EGF/Laminin	Family A G protein-coupled receptor-like	2	2
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	2	2
E set domains	AMPKBI-like	2	1
Trimerization domain of TRAF	TRAF domain-like	2	2
Histone-fold	Ras GEF	2	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
EF-hand	GAS2 domain-like	2	2
p53 tetramerization domain	SAM/Pointed domain	2	2
FnI-like domain	Kringle-like	2	2
CAD & PB1 domains	PDZ domain-like	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	2
PH domain-like	Fibronectin type III	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
Heme-dependent peroxidases	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	1
Ubiquitin-like	Acid proteases	2	1
DBL homology domain (DH-domain)	SH2 domain	2	2
DEATH domain	Toll/Interleukin receptor TIR domain	2	1
LDL receptor-like module	Family A G protein-coupled receptor-like	2	2
PreATP-grasp domain	ClpP/crotonase	2	2
Calpain large subunit, middle domain (domain III)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
Calponin-homology domain, CH-domain	SH3-domain	2	2
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	2	2
L domain-like	PP2C-like	2	2
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
Mib/herc2 domain-like	Mib/herc2 domain-like	2	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	2	1
CAD & PB1 domains	UBA-like	2	2
TAZ domain	Kix domain of CBP (creb binding protein)	2	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	2	1
Inhibitor of apoptosis (IAP) repeat	DEATH domain	2	2
Single hybrid motif	Single hybrid motif	2	2
FnI-like domain	TSP type-3 repeat	2	1
Heme-dependent peroxidases	EF-hand	2	1
UBC-like	Endosomal sorting complex assembly domain	2	1
TRAF domain-like	WD40 repeat-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	2	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	1
Voltage-gated potassium channels	EF-hand	2	1
GFP-like	EGF/Laminin	2	2
PDZ domain-like	Ras GEF	2	2
Ran binding protein zinc finger-like	RING/U-box	2	2
ARM repeat	POZ domain	2	2
FAD-linked reductases, C-terminal domain	Folate-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	2
Tudor/PWWP/MBT	Chromo domain-like	2	1
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	2	1
Taf5 N-terminal domain-like	WD40 repeat-like	2	2
TAZ domain	Bromodomain	2	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	2	2
SMAD/FHA domain	RING/U-box	2	2
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	2	2
RUN domain-like	PH domain-like	2	2
DNA-binding domain	SET domain	2	1
Outer arm dynein light chain 1	L domain-like	2	2
TSP-1 type 1 repeat	Family A G protein-coupled receptor-like	2	2
Carboxypeptidase regulatory domain-like	NHL repeat	2	2
UBA-like	XPC-binding domain	2	2
SWIB/MDM2 domain	Ran binding protein zinc finger-like	2	2
Ankyrin repeat	Hect, E3 ligase catalytic domain	2	2
LDL receptor-like module	Complement control module/SCR domain	2	2
SAM/Pointed domain	RING/U-box	2	2
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
Immunoglobulin	FnI-like domain	2	2
UBC-like	RING/U-box	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Eferin C-derminal domain-like	2	1
Histone-fold	Ankyrin repeat	2	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	2
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	2	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	2	1
CAD & PB1 domains	Cysteine-rich domain	2	1
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	2	2
F-box domain	Pectin lyase-like	2	2
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	2	2
E set domains	Anthrax protective antigen	2	2
Spectrin repeat	RING/U-box	2	2
SH3-domain	Phosphoglycerate mutase-like	2	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	2	2
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	2	1
Growth factor receptor domain	PDZ domain-like	2	2
beta-sandwich domain of Sec23/24	beta-sandwich domain of Sec23/24	2	2
Zinc beta-ribbon	Cyclin-like	2	2
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	2	1
Carbonic anhydrase	(Phosphotyrosine protein) phosphatases II	2	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	2	2
Spermadhesin, CUB domain	TIMP-like	2	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	2	2
WD40 repeat-like	SNARE fusion complex	2	2
Telomeric repeat binding factor (TRF) dimerisation domain	Homeodomain-like	2	1
Protease propeptides/inhibitors	Growth factor receptor domain	2	1
Growth factor receptor domain	Notch domain	2	2
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	2	2
Spectrin repeat	WW domain	2	2
Serine protease inhibitors	AbfB domain	2	2
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	2	2
Ubiquitin-like	XPC-binding domain	2	2
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	2	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	2
Ankyrin repeat	ADP-ribosylation	2	2
Immunoglobulin	EGF/Laminin	2	2
SMAD/FHA domain	PH domain-like	2	2
LCCL domain	vWA-like	2	2
Clavaminate synthase-like	Tudor/PWWP/MBT	2	2
Carboxypeptidase regulatory domain-like	Immunoglobulin	2	1
RING/U-box	PDZ domain-like	2	1
I/LWEQ domain	I/LWEQ domain	2	2
Calponin-homology domain, CH-domain	GTPase activation domain, GAP	2	2
Kix domain of CBP (creb binding protein)	Bromodomain	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	1
SH2 domain	VPS9 domain	2	1
WW domain	PDZ domain-like	2	2
G protein-binding domain	Cysteine-rich domain	2	2
HR1 repeat	Protein kinase-like (PK-like)	2	1
PYP-like sensor domain (PAS domain)	HD-domain/PDEase-like	2	1
Cysteine proteinases	EPT/RTPC-like	2	2
A heparin-binding domain	BPTI-like	2	2
Tudor/PWWP/MBT	ARID-like	2	1
beta-beta-alpha zinc fingers	Hermes dimerisation domain	2	2
FAD/NAD(P)-binding domain	Folate-binding domain	2	2
Growth factor receptor domain	Mannose 6-phosphate receptor domain	2	1
G protein-binding domain	PH domain-like	2	2
UBA-like	SH3-domain	2	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	2	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
SAP domain	P-loop containing nucleoside triphosphate hydrolases	2	2
RNA-binding domain, RBD	SPOC domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Nucleotidylyl transferase	2	2
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	2	2
TPR-like	Fic-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Prefoldin	2	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	2	2
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	2	2
SAM/Pointed domain	SH2 domain	2	2
E set domains	NHL repeat	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	2	2
TPR-like	"Winged helix" DNA-binding domain	2	1
Bromodomain	Nuclear receptor coactivator interlocking domain	2	1
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	2
WD40 repeat-like	Cyclophilin-like	2	2
Kix domain of CBP (creb binding protein)	RING/U-box	2	1
Metalloproteases ("zincins"), catalytic domain	Kringle-like	2	1
Kringle-like	Protein kinase-like (PK-like)	2	2
Anthrax protective antigen	Pectin lyase-like	2	2
Translation proteins	ThrRS/AlaRS common domain	2	1
Dimerization cofactor of HNF-1 alpha	lambda repressor-like DNA-binding domains	2	2
Concanavalin A-like lectins/glucanases	TRAF domain-like	2	2
ACT-like	ACT-like	2	1
Second domain of FERM	DBL homology domain (DH-domain)	2	2
Cysteine proteinases	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	PDZ domain-like	2	2
USP8 N-terminal domain-like	JAB1/MPN domain	2	1
vWA-like	Trypsin-like serine proteases	2	2
Alkaline phosphatase-like	Alkaline phosphatase-like	2	2
beta-beta-alpha zinc fingers	Ribonuclease H-like	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	2	2
GST C-terminal domain-like	S15/NS1 RNA-binding domain	2	2
WWE domain	Hect, E3 ligase catalytic domain	2	2
PRTase-like	PRTase-like	2	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	2	1
CRAL/TRIO domain	GTPase activation domain, GAP	2	1
Heme-dependent peroxidases	Riboflavin synthase domain-like	2	1
ADP-ribosylation	vWA-like	2	2
BPTI-like	LDL receptor-like module	2	2
TPR-like	CAD & PB1 domains	2	2
TPR-like	Clavaminate synthase-like	2	2
L30e-like	alpha/beta knot	2	2
Glucocorticoid receptor-like (DNA-binding domain)	Protein kinase-like (PK-like)	2	2
Heme-dependent peroxidases	Complement control module/SCR domain	2	1
L27 domain	L27 domain	2	2
EGF/Laminin	Ankyrin repeat	2	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	2	2
ENTH/VHS domain	Clathrin adaptor appendage domain	2	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	2	2
Ankyrin repeat	Eukaryotic type KH-domain (KH-domain type I)	2	1
Single hybrid motif	ClpP/crotonase	2	2
SAM/Pointed domain	ADP-ribosylation	2	2
MIR domain	IP3 receptor type 1 binding core, domain 2	2	2
Spectrin repeat	SH3-domain	2	2
vWA-like	SPOC domain-like	2	2
Bet v1-like	HAD-like	2	2
POZ domain	Galactose oxidase, central domain	2	2
WD40 repeat-like	TPR-like	2	2
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	2	2
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	2	1
Concanavalin A-like lectins/glucanases	BEACH domain	2	2
P-loop containing nucleoside triphosphate hydrolases	WW domain	2	2
ENTH/VHS domain	I/LWEQ domain	2	2
NAD kinase/diacylglycerol kinase-like	SAM/Pointed domain	2	2
PreATP-grasp domain	PreATP-grasp domain	2	2
E set domains	Pectin lyase-like	2	2
TSP-1 type 1 repeat	Carboxypeptidase regulatory domain-like	2	1
TPR-like	PUA domain-like	2	1
SAM/Pointed domain	Toll/Interleukin receptor TIR domain	2	2
CCHHC domain	CCHHC domain	2	2
Spectrin repeat	DBL homology domain (DH-domain)	2	2
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	2	1
Cysteine-rich DNA binding domain, (DM domain)	UBA-like	2	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
PAH2 domain	Homeodomain-like	2	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	2
Immunoglobulin	Hormone receptor domain	2	2
(Phosphotyrosine protein) phosphatases II	Chaperone J-domain	2	1
FYVE/PHD zinc finger	WD40 repeat-like	2	2
BPTI-like	CAPPD, an extracellular domain of amyloid beta A4 protein	2	2
SMAD/FHA domain	PDZ domain-like	2	2
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	2	1
CAD & PB1 domains	RING/U-box	2	2
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	2	2
LDL receptor-like module	L domain-like	2	2
GTPase activation domain, GAP	RGC domain-like	2	2
Galactose-binding domain-like	Ankyrin repeat	2	2
Immunoglobulin	Heme-dependent peroxidases	2	2
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	2	1
L domain-like	Heme-dependent peroxidases	2	2
Nucleotide-binding domain	Nucleotide-binding domain	2	2
Nucleic acid-binding proteins	TPR-like	2	2
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	2	2
Elafin-like	Fibronectin type III	2	2
TPR-like	Protein kinase-like (PK-like)	2	2
Cysteine-rich domain	DBL homology domain (DH-domain)	2	1
Tudor/PWWP/MBT	S-adenosyl-L-methionine-dependent methyltransferases	2	2
TRAF domain-like	NRDP1 C-terminal domain-like	2	1
GLA-domain	Concanavalin A-like lectins/glucanases	2	2
Immunoglobulin	Kringle-like	2	2
MIT domain	MIT domain	2	2
Amyloid beta a4 protein copper binding domain (domain 2)	BPTI-like	2	2
Rudiment single hybrid motif	ClpP/crotonase	2	2
FYVE/PHD zinc finger	SMAD/FHA domain	2	2
Kringle-like	C-type lectin-like	2	1
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
Hermes dimerisation domain	Ribonuclease H-like	2	2
Second domain of FERM	SH2 domain	2	2
TAZ domain	TAZ domain	2	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	2
L domain-like	DNase I-like	2	1
PUA domain-like	Ribosomal protein S5 domain 2-like	2	1
DBL homology domain (DH-domain)	Protein kinase-like (PK-like)	2	2
Galactose-binding domain-like	RING/U-box	2	2
Prefoldin	WD40 repeat-like	2	1
RING/U-box	NRDP1 C-terminal domain-like	2	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	2	2
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
Concanavalin A-like lectins/glucanases	TSP-1 type 1 repeat	2	1
Kazal-type serine protease inhibitors	Concanavalin A-like lectins/glucanases	2	2
DUSP-like	DUSP-like	2	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
GAT-like domain	Clathrin adaptor appendage domain	2	1
TAFH domain-like	Histone-fold	2	1
Tudor/PWWP/MBT	Galactose-binding domain-like	2	2
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	2	2
Cupredoxins	Galactose-binding domain-like	2	2
DNase I-like	RNA-binding domain, RBD	2	1
DBL homology domain (DH-domain)	GTPase activation domain, GAP	2	1
Intermediate filament protein, coiled coil region	Myosin rod fragments	2	1
Histone-fold	PH domain-like	2	2
Tudor/PWWP/MBT	Cullin homology domain	2	2
L domain-like	SAM/Pointed domain	2	2
Chromo domain-like	SET domain	2	1
Concanavalin A-like lectins/glucanases	(Phosphotyrosine protein) phosphatases II	2	1
Cystatin/monellin	Cysteine proteinases	2	1
Mib/herc2 domain-like	RING/U-box	2	1
RING/U-box	Nuclear receptor coactivator interlocking domain	2	1
Domain of poly(ADP-ribose) polymerase	vWA-like	2	2
Kix domain of CBP (creb binding protein)	Nuclear receptor coactivator interlocking domain	2	1
Histone-fold	POZ domain	2	2
vWA-like	BPTI-like	2	2
Carbonic anhydrase	Fibronectin type III	2	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	2	1
MIT domain	F-box domain	1	1
NagB/RpiA/CoA transferase-like	RNA-binding domain, RBD	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
SPOC domain-like	SAP domain	1	1
TRAF domain-like	Cysteine proteinases	1	1
RNA-binding domain, RBD	Macro domain-like	1	1
Putative DNA-binding domain	Cation efflux protein transmembrane domain-like	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	1	1
UBA-like	P-loop containing nucleoside triphosphate hydrolases	1	1
L domain-like	Hormone receptor domain	1	1
Arginase/deacetylase	RING/U-box	1	1
PUG domain-like	Cysteine proteinases	1	1
Cadherin-like	Dystroglycan, domain 2	1	1
vWA-like	Sensory domain-like	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Doublecortin (DC)	POZ domain	1	1
TPR-like	beta-beta-alpha zinc fingers	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	1	1
CRAL/TRIO N-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
F-box domain	Cyclin-like	1	1
FMN-linked oxidoreductases	dsRNA-binding domain-like	1	1
PH domain-like	Tricorn protease domain 2	1	1
Spermadhesin, CUB domain	Family A G protein-coupled receptor-like	1	1
PLP-dependent transferases	PK beta-barrel domain-like	1	1
GTF2I-like repeat	Ribonuclease H-like	1	1
Protein kinase-like (PK-like)	Tricorn protease domain 2	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
"Winged helix" DNA-binding domain	RING/U-box	1	1
TPR-like	CCCH zinc finger	1	1
Multidrug efflux transporter AcrB transmembrane domain	NAD-binding domain of HMG-CoA reductase	1	1
PH domain-like	Glycolipid transfer protein, GLTP	1	1
Pseudouridine synthase	PUA domain-like	1	1
Cytochrome b5-like heme/steroid binding domain	Mib/herc2 domain-like	1	1
NHL repeat	Calcium-dependent phosphotriesterase	1	1
Homeodomain-like	JAB1/MPN domain	1	1
GTPase activation domain, GAP	VPS9 domain	1	1
Seven-hairpin glycosidases	PA domain	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SET domain	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
PH domain-like	HMG-box	1	1
F-box domain	RCC1/BLIP-II	1	1
vWA-like	C-terminal domain of Ku80	1	1
PR-1-like	C-type lectin-like	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
Tudor/PWWP/MBT	HSP20-like chaperones	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
Tudor/PWWP/MBT	HMG-box	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
Elafin-like	Kazal-type serine protease inhibitors	1	1
Histone-fold	Macro domain-like	1	1
FabD/lysophospholipase-like	FabD/lysophospholipase-like	1	1
Cysteine proteinases	Tudor/PWWP/MBT	1	1
Tudor/PWWP/MBT	Protein kinase-like (PK-like)	1	1
ARID-like	ARM repeat	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
GST C-terminal domain-like	Class II aaRS and biotin synthetases	1	1
F-box domain	YccV-like	1	1
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	1	1
PH domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	1	1
Ubiquitin-like	Ran binding protein zinc finger-like	1	1
Cullin homology domain	RING/U-box	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
Growth factor receptor domain	Chicken cartilage matrix protein	1	1
Aldolase	AFP III-like domain	1	1
PHM/PNGase F	NHL repeat	1	1
Sm-like ribonucleoproteins	Sm-like ribonucleoproteins	1	1
E set domains	Ankyrin repeat	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
Ankyrin repeat	EF-hand	1	1
MPN010-like	SAM/Pointed domain	1	1
PX domain	Outer arm dynein light chain 1	1	1
L domain-like	DEATH domain	1	1
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	1	1
L domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
TB module/8-cys domain	Kazal-type serine protease inhibitors	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
EF-hand	UBA-like	1	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	1	1
Rab geranylgeranyltransferase alpha-subunit, insert domain	Outer arm dynein light chain 1	1	1
Carboxypeptidase regulatory domain-like	Calcium-dependent phosphotriesterase	1	1
VPS9 domain	Ubiquitin-like	1	1
Ankyrin repeat	WD40 repeat-like	1	1
Cupredoxins	Pectin lyase-like	1	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	1	1
A middle domain of Talin 1	alpha-catenin/vinculin-like	1	1
BAR/IMD domain-like	Protein kinase-like (PK-like)	1	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	1	1
RCC1/BLIP-II	RING/U-box	1	1
SEA domain	Immunoglobulin	1	1
Second domain of FERM	RING/U-box	1	1
Myosin rod fragments	Cysteine-rich domain	1	1
MFS general substrate transporter	alpha/beta knot	1	1
FAD-linked reductases, C-terminal domain	EF-hand	1	1
Bromodomain	HIT/MYND zinc finger-like	1	1
POZ domain	Pentapeptide repeat-like	1	1
MIT domain	Calpain large subunit, middle domain (domain III)	1	1
Ras GEF	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
SET domain	WW domain	1	1
HR1 repeat	SH3-domain	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
WD40 repeat-like	Integrin alpha N-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	1	1
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	1	1
HLH, helix-loop-helix DNA-binding domain	Positive stranded ssRNA viruses	1	1
Concanavalin A-like lectins/glucanases	SRCR-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
BAR/IMD domain-like	HR1 repeat	1	1
BPTI-like	TIMP-like	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
RCC1/BLIP-II	VPS9 domain	1	1
ArfGap/RecO-like zinc finger	SH3-domain	1	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	1	1
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	1	1
Ubiquitin-like	AN1-like Zinc finger	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
PDZ domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HMG-box	1	1
RNA-binding domain, RBD	Clavaminate synthase-like	1	1
Rudiment single hybrid motif	post-HMGL domain-like	1	1
NAD(P)-binding Rossmann-fold domains	SCP-like	1	1
F-box domain	Kelch motif	1	1
Ras GEF	PLC-like phosphodiesterases	1	1
PurS-like	PurM C-terminal domain-like	1	1
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Protein kinase-like (PK-like)	L27 domain	1	1
SH2 domain	UBA-like	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Ubiquitin-like	BAG domain	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	1	1
Kringle-like	Fibronectin type III	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
PDZ domain-like	Flavoproteins	1	1
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Integrin beta tail domain	Fibronectin type III	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	1	1
UBC-like	LDH C-terminal domain-like	1	1
NAD(P)-binding Rossmann-fold domains	ACP-like	1	1
PH domain-like	FAT domain of focal adhesion kinase	1	1
ARM repeat	SAM/Pointed domain	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Macro domain-like	WWE domain	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	1	1
Anthrax protective antigen	Cupredoxins	1	1
ACP-like	ALDH-like	1	1
UBC-like	NAD(P)-binding Rossmann-fold domains	1	1
WW domain	RGC domain-like	1	1
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	1	1
YWTD domain	Protein kinase-like (PK-like)	1	1
Galactose oxidase, central domain	Quinoprotein alcohol dehydrogenase-like	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
SAM/Pointed domain	Bet v1-like	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
Serpins	Serpins	1	1
"Winged helix" DNA-binding domain	SAICAR synthase-like	1	1
Calponin-homology domain, CH-domain	E set domains	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
"Winged helix" DNA-binding domain	Cyclin-like	1	1
ARM repeat	Mib/herc2 domain-like	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	1	1
E set domains	Kazal-type serine protease inhibitors	1	1
beta-beta-alpha zinc fingers	FYVE/PHD zinc finger	1	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	1	1
Concanavalin A-like lectins/glucanases	FYVE/PHD zinc finger	1	1
DBL homology domain (DH-domain)	VPS9 domain	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Thioredoxin-like	NHL repeat	1	1
SH3-domain	Quinoprotein alcohol dehydrogenase-like	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	1	1
Ribosomal protein S5 domain 2-like	HMG-box	1	1
Ribosomal protein L25-like	Class II aaRS ABD-related	1	1
SET domain	Bromodomain	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
Second domain of FERM	A middle domain of Talin 1	1	1
Rudiment single hybrid motif	Aldolase	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
EGF/Laminin	SEA domain	1	1
ARM repeat	alpha/beta knot	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	1	1
WD40 repeat-like	Hect, E3 ligase catalytic domain	1	1
Cytochrome b5-like heme/steroid binding domain	HSP20-like chaperones	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
PH domain-like	Cyclophilin-like	1	1
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	1	1
UBC-like	UBC-like	1	1
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	1	1
Rudiment single hybrid motif	Formyltransferase	1	1
Spermadhesin, CUB domain	Frizzled cysteine-rich domain	1	1
ARM repeat	Rap/Ran-GAP	1	1
Ankyrin repeat	FYVE/PHD zinc finger	1	1
PH domain-like	Ypt/Rab-GAP domain of gyp1p	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
HSP20-like chaperones	HIT/MYND zinc finger-like	1	1
TIMP-like	SEA domain	1	1
E set domains	Cupredoxins	1	1
LDL receptor-like module	C-type lectin-like	1	1
PABC (PABP) domain	Hect, E3 ligase catalytic domain	1	1
SAM/Pointed domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Thiolase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PUA domain-like	eIF1-like	1	1
Ankyrin repeat	Nudix	1	1
SMAD/FHA domain	PX domain	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
GroEL apical domain-like	SAICAR synthase-like	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
DNA-glycosylase	Nudix	1	1
PH domain-like	RNI-like	1	1
PreATP-grasp domain	Formyltransferase	1	1
Hemopexin-like domain	Hemopexin-like domain	1	1
Nucleotide-binding domain	FAD/NAD(P)-binding domain	1	1
"Winged helix" DNA-binding domain	dsRNA-binding domain-like	1	1
PH domain-like	PP2C-like	1	1
Ubiquitin-like	A middle domain of Talin 1	1	1
ISP domain	Metallo-hydrolase/oxidoreductase	1	1
Frizzled cysteine-rich domain	SRCR-like	1	1
PH domain-like	BSD domain-like	1	1
Galactose oxidase, central domain	FYVE/PHD zinc finger	1	1
PLC-like phosphodiesterases	Ubiquitin-like	1	1
vWA-like	Cysteine-rich domain	1	1
Staphylococcal nuclease	Protein kinase-like (PK-like)	1	1
GST C-terminal domain-like	C-terminal domain of ProRS	1	1
R3H domain	AN1-like Zinc finger	1	1
RING/U-box	RNA-binding domain, RBD	1	1
EGF/Laminin	TNF-like	1	1
Histone-fold	ARM repeat	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
FYVE/PHD zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Bacterial hemolysins	C-type lectin-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	SAM/Pointed domain	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	1	1
Aldolase	post-HMGL domain-like	1	1
Thioredoxin-like	ERP29 C domain-like	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Second domain of FERM	FAT domain of focal adhesion kinase	1	1
Saposin	SGNH hydrolase	1	1
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	1	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Ubiquitin-like	EPT/RTPC-like	1	1
PX domain	Phospholipase D/nuclease	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
BRCT domain	DNA/RNA polymerases	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
FYVE/PHD zinc finger	EF-hand	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	1	1
PAZ domain	RNase III domain-like	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
SWIB/MDM2 domain	SWIB/MDM2 domain	1	1
Spectrin repeat	Immunoglobulin	1	1
Calponin-homology domain, CH-domain	RGC domain-like	1	1
Ubiquitin-like	PUA domain-like	1	1
gamma-Crystallin-like	Ricin B-like lectins	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
PX domain	GTPase activation domain, GAP	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
Metalloproteases ("zincins"), catalytic domain	Immunoglobulin	1	1
Kringle-like	SRCR-like	1	1
Kelch motif	Growth factor receptor domain	1	1
MoeA N-terminal region -like	MoeA C-terminal domain-like	1	1
UBA-like	Tudor/PWWP/MBT	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
Tropomyosin	FYVE/PHD zinc finger	1	1
Fibronectin type III	YWTD domain	1	1
TRADD, N-terminal domain	DEATH domain	1	1
RCC1/BLIP-II	Concanavalin A-like lectins/glucanases	1	1
Sema domain	Protein kinase-like (PK-like)	1	1
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	1	1
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
MIT domain	Cysteine proteinases	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	CCCH zinc finger	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
KRAB domain (Kruppel-associated box)	Homeodomain-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Protein kinase-like (PK-like)	Myosin rod fragments	1	1
CHY zinc finger-like	Zinc hairpin stack	1	1
P-loop containing nucleoside triphosphate hydrolases	Tricorn protease N-terminal domain	1	1
RNA-binding domain, RBD	Tudor/PWWP/MBT	1	1
Nucleotide-binding domain	FMN-linked oxidoreductases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
Rhomboid-like	UBA-like	1	1
FnI-like domain	CalX-like	1	1
P-loop containing nucleoside triphosphate hydrolases	ArfGap/RecO-like zinc finger	1	1
GFP-like	YWTD domain	1	1
TPR-like	UBA-like	1	1
PH domain-like	Phospholipase D/nuclease	1	1
WD40 repeat-like	SH3-domain	1	1
RING/U-box	Protein kinase-like (PK-like)	1	1
Quinoprotein alcohol dehydrogenase-like	ARM repeat	1	1
Frizzled cysteine-rich domain	Trypsin-like serine proteases	1	1
Pre-PUA domain	PUA domain-like	1	1
Plexin repeat	Protein kinase-like (PK-like)	1	1
Tropomyosin	Tropomyosin	1	1
Tudor/PWWP/MBT	RING/U-box	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
SIS domain	SIS domain	1	1
Ankyrin repeat	Myosin rod fragments	1	1
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	1	1
TAF(II)230 TBP-binding fragment	Bromodomain	1	1
Chromo domain-like	Ankyrin repeat	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
GroEL-intermediate domain like	SAICAR synthase-like	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
Nucleotidylyl transferase	SH2 domain	1	1
PH domain-like	L domain-like	1	1
HR1 repeat	PDZ domain-like	1	1
Formyltransferase	ACP-like	1	1
RuvA domain 2-like	RuvA domain 2-like	1	1
GST C-terminal domain-like	Methionyl-tRNA synthetase (MetRS), Zn-domain	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
PUG domain-like	RING/U-box	1	1
RCC1/BLIP-II	PH domain-like	1	1
Galactose-binding domain-like	BRCT domain	1	1
Outer arm dynein light chain 1	Toll/Interleukin receptor TIR domain	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	1	1
Kazal-type serine protease inhibitors	BPTI-like	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
N-terminal domain of cbl (N-cbl)	UBA-like	1	1
MIR domain	MIR domain	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
Ubiquitin-like	Cap-Gly domain	1	1
Rabenosyn-5 Rab-binding domain-like	Rabenosyn-5 Rab-binding domain-like	1	1
C-terminal domain of adenylylcyclase associated protein	Nucleoside diphosphate kinase, NDK	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
Ankyrin repeat	BRCT domain	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
FnI-like domain	vWA-like	1	1
L domain-like	PKD domain	1	1
Ribonuclease H-like	"Winged helix" DNA-binding domain	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
HBS1-like domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	1	1
Annexin	Annexin	1	1
Carbamate kinase-like	Acyl-CoA N-acyltransferases (Nat)	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
F-box domain	SMI1/KNR4-like	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	HIT/MYND zinc finger-like	1	1
RNA-binding domain, RBD	ADP-ribosylation	1	1
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	1	1
PH domain-like	Immunoglobulin	1	1
CCCH zinc finger	Tudor/PWWP/MBT	1	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	1	1
Lipocalins	BPTI-like	1	1
FnI-like domain	AbfB domain	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
LEM domain	LEM domain	1	1
SEA domain	Family A G protein-coupled receptor-like	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
Serine protease inhibitors	EGF/Laminin	1	1
PurM N-terminal domain-like	Formyltransferase	1	1
LDL receptor-like module	Fibronectin type III	1	1
GLA-domain	Growth factor receptor domain	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
RCC1/BLIP-II	WD40 repeat-like	1	1
SMAD/FHA domain	HAD-like	1	1
E set domains	Hect, E3 ligase catalytic domain	1	1
PreATP-grasp domain	PurM C-terminal domain-like	1	1
Tudor/PWWP/MBT	CCHHC domain	1	1
Chaperone J-domain	CSL zinc finger	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
WW domain	Quinoprotein alcohol dehydrogenase-like	1	1
FAS1 domain	Growth factor receptor domain	1	1
Clathrin heavy-chain terminal domain	ARM repeat	1	1
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	1	1
FYVE/PHD zinc finger	GroEL apical domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	GTPase activation domain, GAP	1	1
Ankyrin repeat	L domain-like	1	1
Immunoglobulin	TIMP-like	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
P-loop containing nucleoside triphosphate hydrolases	E set domains	1	1
Plexin repeat	CalX-like	1	1
POZ domain	FYVE/PHD zinc finger	1	1
L domain-like	Soluble quinoprotein glucose dehydrogenase	1	1
Tricorn protease domain 2	TPR-like	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
Protein kinase-like (PK-like)	UBA-like	1	1
Terpenoid cyclases/Protein prenyltransferases	Kazal-type serine protease inhibitors	1	1
PurM C-terminal domain-like	Formyltransferase	1	1
beta-sandwich domain of Sec23/24	Voltage-gated potassium channels	1	1
Immunoglobulin	Caspase-like	1	1
SWIB/MDM2 domain	eIF1-like	1	1
VPS9 domain	Ankyrin repeat	1	1
UBA-like	WWE domain	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	1	1
Cadherin-like	Protein kinase-like (PK-like)	1	1
Nucleotidylyl transferase	C-terminal domain of ProRS	1	1
L domain-like	Putative isomerase YbhE	1	1
GST C-terminal domain-like	eEF-1beta-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Chaperone J-domain	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
FnI-like domain	Fibronectin type III	1	1
Ubiquitin-like	FYVE/PHD zinc finger	1	1
TPR-like	Chaperone J-domain	1	1
PDZ domain-like	Riboflavin synthase domain-like	1	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
HSP20-like chaperones	Cysteine proteinases	1	1
WD40 repeat-like	Ypt/Rab-GAP domain of gyp1p	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
SCP-like	L domain-like	1	1
Kelch motif	NHL repeat	1	1
p53-like transcription factors	DEATH domain	1	1
HIT/MYND zinc finger-like	SET domain	1	1
Starch-binding domain-like	PLC-like phosphodiesterases	1	1
Calponin-homology domain, CH-domain	Ubiquitin-like	1	1
Ankyrin repeat	FabD/lysophospholipase-like	1	1
GFP-like	Thyroglobulin type-1 domain	1	1
PH domain-like	Ran binding protein zinc finger-like	1	1
ADP-ribosylglycohydrolase	Ypt/Rab-GAP domain of gyp1p	1	1
Ribonuclease H-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	1	1
Rudiment single hybrid motif	PurM C-terminal domain-like	1	1
"Winged helix" DNA-binding domain	GTPase activation domain, GAP	1	1
L domain-like	C-type lectin-like	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
NHL repeat	DPP6 N-terminal domain-like	1	1
Apyrase	Apyrase	1	1
FYVE/PHD zinc finger	GroEL-intermediate domain like	1	1
L9 N-domain-like	Ribonuclease H-like	1	1
"Winged helix" DNA-binding domain	E set domains	1	1
Elafin-like	TIMP-like	1	1
TIMP-like	Concanavalin A-like lectins/glucanases	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Ubiquitin-like	HAD-like	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Metallo-dependent phosphatases	HIT-like	1	1
BEACH domain	FYVE/PHD zinc finger	1	1
TPR-like	HSP20-like chaperones	1	1
Galactose-binding domain-like	Fibrinogen C-terminal domain-like	1	1
Ankyrin repeat	Second domain of FERM	1	1
HIT-like	HIT-like	1	1
"Winged helix" DNA-binding domain	GroEL-intermediate domain like	1	1
GST C-terminal domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Glutathione synthetase ATP-binding domain-like	Formyltransferase	1	1
Ribosomal protein L25-like	C-terminal domain of ProRS	1	1
SEA domain	Concanavalin A-like lectins/glucanases	1	1
NAD kinase/diacylglycerol kinase-like	Ankyrin repeat	1	1
USP8 N-terminal domain-like	Cysteine proteinases	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
Metalloproteases ("zincins"), catalytic domain	Growth factor receptor domain	1	1
PreATP-grasp domain	Metallo-dependent hydrolases	1	1
RCC1/BLIP-II	E set domains	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	1	1
Zinc hairpin stack	RING/U-box	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
(Trans)glycosidases	Acyl-CoA N-acyltransferases (Nat)	1	1
Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	1	1
Spectrin repeat	Fibronectin type III	1	1
E set domains	DEATH domain	1	1
beta-sandwich domain of Sec23/24	Small-conductance potassium channel	1	1
Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
alpha-helical ferredoxin	Nucleotide-binding domain	1	1
FMT C-terminal domain-like	ACP-like	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
beta-beta-alpha zinc fingers	Formin homology 2 domain (FH2 domain)	1	1
Acyl-CoA binding protein	ClpP/crotonase	1	1
P-loop containing nucleoside triphosphate hydrolases	FF domain	1	1
PRP4-like	WD40 repeat-like	1	1
Clavaminate synthase-like	RNI-like	1	1
RCC1/BLIP-II	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
SPOC domain-like	C-terminal domain of Ku80	1	1
PH domain-like	I/LWEQ domain	1	1
L domain-like	RING/U-box	1	1
alpha-helical ferredoxin	FMN-linked oxidoreductases	1	1
PH domain-like	Bet v1-like	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	1	1
vWA-like	SAP domain	1	1
Retrovirus zinc finger-like domains	P-loop containing nucleoside triphosphate hydrolases	1	1
Quinoprotein alcohol dehydrogenase-like	EF-hand	1	1
GDNF receptor-like	GDNF receptor-like	1	1
RNA-binding domain, RBD	WWE domain	1	1
Complement control module/SCR domain	Periplasmic binding protein-like I	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	1	1
Growth factor receptor domain	Family A G protein-coupled receptor-like	1	1
Somatomedin B domain	Complement control module/SCR domain	1	1
TPR-like	PIN domain-like	1	1
CRAL/TRIO domain	Fibronectin type III	1	1
PH domain-like	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
RING/U-box	Cyclophilin-like	1	1
HSP20-like chaperones	HSP20-like chaperones	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
SAP domain	Ribonuclease H-like	1	1
E set domains	Galactose-binding domain-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Doublecortin (DC)	Pentapeptide repeat-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
Dcp2 domain-like	Nudix	1	1
Alpha-macroglobulin receptor domain	Kazal-type serine protease inhibitors	1	1
DEATH domain	Tropomyosin	1	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	1	1
Galactose mutarotase-like	Galactose mutarotase-like	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	1	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	1	1
Acid proteases	DNA/RNA polymerases	1	1
P-loop containing nucleoside triphosphate hydrolases	PX domain	1	1
FYVE/PHD zinc finger	SAP domain	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
Myosin rod fragments	G protein-binding domain	1	1
beta-sandwich domain of Sec23/24	p53-like transcription factors	1	1
Ribonuclease H-like	SH2 domain	1	1
B-box zinc-binding domain	TRAF domain-like	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
Apolipoprotein A-I	Apolipoprotein A-I	1	1
Kazal-type serine protease inhibitors	LDL receptor-like module	1	1
N-terminal coiled coil domain from apc	Tumor suppressor gene product Apc	1	1
GTPase activation domain, GAP	ARM repeat	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
CRAL/TRIO domain	SH3-domain	1	1
beta-sandwich domain of Sec23/24	ARM repeat	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
ARM repeat	UBA-like	1	1
PKD domain	C-type lectin-like	1	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	1	1
USP8 N-terminal domain-like	Rhodanese/Cell cycle control phosphatase	1	1
Cysteine proteinases	Galactose-binding domain-like	1	1
Rap30/74 interaction domains	Rap30/74 interaction domains	1	1
PKD domain	LDL receptor-like module	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Chaperone J-domain	1	1
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	1	1
Tudor/PWWP/MBT	NAD(P)-binding Rossmann-fold domains	1	1
Metalloproteases ("zincins"), catalytic domain	Fibronectin type III	1	1
Cysteine-rich domain	Tricorn protease domain 2	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
Kringle-like	Spermadhesin, CUB domain	1	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
Tricorn protease domain 2	ARM repeat	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
PYP-like sensor domain (PAS domain)	Positive stranded ssRNA viruses	1	1
KRAB domain (Kruppel-associated box)	Ribonuclease H-like	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HSP20-like chaperones	1	1
Myosin rod fragments	PH domain-like	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	1	1
Nucleotide-diphospho-sugar transferases	HAD-like	1	1
EGF/Laminin	DPP6 N-terminal domain-like	1	1
Thyroglobulin type-1 domain	YWTD domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	1	1
POZ domain	Leucine zipper domain	1	1
Quinoprotein alcohol dehydrogenase-like	PH domain-like	1	1
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
p53-like transcription factors	SAM/Pointed domain	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
PreATP-grasp domain	PurM N-terminal domain-like	1	1
DBL homology domain (DH-domain)	"Winged helix" DNA-binding domain	1	1
Spermadhesin, CUB domain	LCCL domain	1	1
Second domain of FERM	I/LWEQ domain	1	1
YccV-like	ApaG-like	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
ALDH-like	ALDH-like	1	1
Cyclophilin-like	TPR-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
Tex N-terminal region-like	SH2 domain	1	1
HMG-box	Chromo domain-like	1	1
I/LWEQ domain	alpha-catenin/vinculin-like	1	1
HMA, heavy metal-associated domain	HAD-like	1	1
Vacuolar ATP synthase subunit C	Vacuolar ATP synthase subunit C	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
SH3-domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Ankyrin repeat	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
TSP-1 type 1 repeat	TIMP-like	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
Galactose-binding domain-like	Hect, E3 ligase catalytic domain	1	1
F-box domain	Sec7 domain	1	1
beta-beta-alpha zinc fingers	Leucine zipper domain	1	1
PH domain-like	A middle domain of Talin 1	1	1
beta-beta-alpha zinc fingers	Nucleotidyltransferase	1	1
Galactose-binding domain-like	Mib/herc2 domain-like	1	1
DAK1/DegV-like	DhaL-like	1	1
CCCH zinc finger	Protein kinase-like (PK-like)	1	1
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	1	1
Galactose oxidase, central domain	Galactose oxidase, central domain	1	1
alpha-helical ferredoxin	4Fe-4S ferredoxins	1	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	1	1
BAG domain	BAG domain	1	1
PurS-like	Class I glutamine amidotransferase-like	1	1
FMN-linked oxidoreductases	4Fe-4S ferredoxins	1	1
Homeodomain-like	Formin homology 2 domain (FH2 domain)	1	1
Chaperone J-domain	RNA-binding domain, RBD	1	1
TPR-like	RNA-binding domain, RBD	1	1
TNF-like	TNF-like	1	1
DUSP-like	EPT/RTPC-like	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	1	1
UBA-like	DNase I-like	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
BRCT domain	ADP-ribosylation	1	1
Tudor/PWWP/MBT	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
HBS1-like domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
dsRNA-binding domain-like	R3H domain	1	1
RING/U-box	SH3-domain	1	1
DEATH domain	PDZ domain-like	1	1
Aconitase iron-sulfur domain	Aconitase iron-sulfur domain	1	1
SH2 domain	Cysteine-rich domain	1	1
TSP-1 type 1 repeat	Spermadhesin, CUB domain	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	1	1
TRAF domain-like	EGF/Laminin	1	1
ISP domain	FAD/NAD(P)-binding domain	1	1
CRAL/TRIO N-terminal domain	PapD-like	1	1
RuvA domain 2-like	SH2 domain	1	1
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
UBC-like	UBA-like	1	1
FYVE/PHD zinc finger	Hect, E3 ligase catalytic domain	1	1
Thiolase-like	FabD/lysophospholipase-like	1	1
PH domain-like	VPS9 domain	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
Growth factor receptor domain	CalX-like	1	1
Molybdenum cofactor biosynthesis proteins	Adenine nucleotide alpha hydrolases-like	1	1
TPR-like	Metallo-dependent phosphatases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
Concanavalin A-like lectins/glucanases	Trypsin-like serine proteases	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	1	1
HAD-like	HAD-like	1	1
HIN-2000 domain-like	HIN-2000 domain-like	1	1
FAS1 domain	C-type lectin-like	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	1	1
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Ran binding protein zinc finger-like	1	1
Thioredoxin-like	FAD-dependent thiol oxidase	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Kazal-type serine protease inhibitors	SRCR-like	1	1
PKD domain	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
post-HMGL domain-like	Single hybrid motif	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Actin depolymerizing proteins	SH3-domain	1	1
N-terminal coiled coil domain from apc	ARM repeat	1	1
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	1	1
Ankyrin repeat	RNI-like	1	1
Starch-binding domain-like	Carboxypeptidase regulatory domain-like	1	1
F-box domain	PH domain-like	1	1
Carbamate kinase-like	ALDH-like	1	1
Tudor/PWWP/MBT	HIV integrase-binding domain	1	1
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	1	1
EGF/Laminin	CalX-like	1	1
Mitotic arrest deficient-like 1, Mad1	Eferin C-derminal domain-like	1	1
RNase III domain-like	RNase III domain-like	1	1
Doublecortin (DC)	Ricin B-like lectins	1	1
SMAD/FHA domain	HIT-like	1	1
HMG-box	P-loop containing nucleoside triphosphate hydrolases	1	1
Galactose oxidase, central domain	Fibronectin type III	1	1
EGF/Laminin	Thyroglobulin type-1 domain	1	1
PUG domain-like	Galactose-binding domain-like	1	1
FnI-like domain	Trypsin-like serine proteases	1	1
Cysteine proteinases	HIT/MYND zinc finger-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	1	1
Concanavalin A-like lectins/glucanases	Serine protease inhibitors	1	1
Aldolase	Single hybrid motif	1	1
Cystine-knot cytokines	Heparin-binding domain from vascular endothelial growth factor	1	1
PUG domain-like	Ran binding protein zinc finger-like	1	1
HAD-like	alpha/beta-Hydrolases	1	1
Ypt/Rab-GAP domain of gyp1p	SH3-domain	1	1
RAP domain-like	RAP domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Cap-Gly domain	1	1
EF-hand	GAF domain-like	1	1
Protein prenylyltransferase	Rab geranylgeranyltransferase alpha-subunit, insert domain	1	1
Ran binding protein zinc finger-like	Cyclophilin-like	1	1
Nucleotide-binding domain	4Fe-4S ferredoxins	1	1
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	1	1
WD40 repeat-like	HMG-box	1	1
Non-globular alpha+beta subunits of globular proteins	ISP domain	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
Macro domain-like	CRAL/TRIO domain	1	1
Ubiquitin-like	I/LWEQ domain	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
BSD domain-like	BSD domain-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Metalloproteases ("zincins"), catalytic domain	1	1
RNA-binding domain, RBD	Nucleotidyltransferase	1	1
PDZ domain-like	BAR/IMD domain-like	1	1
CRAL/TRIO domain	PapD-like	1	1
C-type lectin-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
PH domain-like	alpha-catenin/vinculin-like	1	1
MAST3 pre-PK domain-like	PDZ domain-like	1	1
Voltage-gated potassium channels	(Phosphotyrosine protein) phosphatases II	1	1
KRAB domain (Kruppel-associated box)	SET domain	1	1
ISP transmembrane anchor	ISP domain	1	1
SAM/Pointed domain	Ubiquitin-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	CCCH zinc finger	1	1
Ribokinase-like	Ribokinase-like	1	1
Retrovirus zinc finger-like domains	RING/U-box	1	1
BRK domain-like	BRK domain-like	1	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	1	1
RCC1/BLIP-II	DBL homology domain (DH-domain)	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
DBL homology domain (DH-domain)	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
WD40 repeat-like	Cysteine proteinases	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
PX domain	CAD & PB1 domains	1	1
P-loop containing nucleoside triphosphate hydrolases	Tryptophan synthase beta subunit-like PLP-dependent enzymes	1	1
CHY zinc finger-like	RING/U-box	1	1
"Winged helix" DNA-binding domain	Acyl-CoA N-acyltransferases (Nat)	1	1
EGF/Laminin	NHL repeat	1	1
Kelch motif	YWTD domain	1	1
RING/U-box	beta-beta-alpha zinc fingers	1	1
PurS-like	PurM N-terminal domain-like	1	1
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
DNA-binding protein LAG-1 (CSL)	E set domains	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
Cysteine-rich domain	SAM/Pointed domain	1	1
FYVE/PHD zinc finger	SAICAR synthase-like	1	1
GLA-domain	Kringle-like	1	1
WD40 repeat-like	dsRNA-binding domain-like	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	1	1
Soluble quinoprotein glucose dehydrogenase	SRCR-like	1	1
Elafin-like	EGF/Laminin	1	1
DBL homology domain (DH-domain)	WD40 repeat-like	1	1
Single hybrid motif	HAD-like	1	1
Galactose-binding domain-like	Kelch motif	1	1
Protein kinase-like (PK-like)	Ras GEF	1	1
SAP domain	RING/U-box	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
TPR-like	RNI-like	1	1
Plexin repeat	Plexin repeat	1	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
P-loop containing nucleoside triphosphate hydrolases	R3H domain	1	1
Ubiquitin-like	FAT domain of focal adhesion kinase	1	1
Chaperone J-domain	E set domains	1	1
Outer arm dynein light chain 1	RNI-like	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	Tricorn protease N-terminal domain	1	1
TIMP-like	Growth factor receptor domain	1	1
LDL receptor-like module	Mannose 6-phosphate receptor domain	1	1
PX domain	Retrovirus zinc finger-like domains	1	1
vWA-like	CalX-like	1	1
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	1	1
SEA domain	Growth factor receptor domain	1	1
RCC1/BLIP-II	Galactose-binding domain-like	1	1
Outer arm dynein light chain 1	PDZ domain-like	1	1
Trefoil	Trefoil	1	1
Kringle-like	HCP-like	1	1
B-box zinc-binding domain	B-box zinc-binding domain	1	1
Protein prenylyltransferase	Outer arm dynein light chain 1	1	1
Elafin-like	Immunoglobulin	1	1
CAD & PB1 domains	His-Me finger endonucleases	1	1
UBC-like	Ribosomal protein S5 domain 2-like	1	1
Granulin repeat	Granulin repeat	1	1
Serine protease inhibitors	vWA-like	1	1
WW domain	NAD(P)-binding Rossmann-fold domains	1	1
SWIB/MDM2 domain	RING/U-box	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
Pentapeptide repeat-like	RNA-binding domain, RBD	1	1
Voltage-gated potassium channels	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
CRAL/TRIO domain	Protein kinase-like (PK-like)	1	1
WW domain	BAG domain	1	1
Nucleotidylyl transferase	Ribosomal protein L25-like	1	1
DNA-binding domain	Bromodomain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Kelch motif	1	1
"Winged helix" DNA-binding domain	cAMP-binding domain-like	1	1
Nucleotidylyl transferase	Class II aaRS ABD-related	1	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
PDZ domain-like	Cysteine-rich domain	1	1
DBL homology domain (DH-domain)	Fibronectin type III	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
Kazal-type serine protease inhibitors	SEA domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
FnI-like domain	Cysteine proteinases	1	1
NHL repeat	NHL repeat	1	1
Translation proteins	Translation proteins	1	1
PUG domain-like	Ubiquitin-like	1	1
Non-globular alpha+beta subunits of globular proteins	ISP transmembrane anchor	1	1
PH domain-like	RING/U-box	1	1
Spectrin repeat	Protein kinase-like (PK-like)	1	1
DNA clamp	DNA clamp	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
ARM repeat	alpha/beta-Hydrolases	1	1
WW domain	dsRNA-binding domain-like	1	1
YaeB-like	YaeB-like	1	1
Plexin repeat	Fibronectin type III	1	1
Cytochrome P450	Cytochrome P450	1	1
PX domain	PH domain-like	1	1
FYVE/PHD zinc finger	Rabenosyn-5 Rab-binding domain-like	1	1
WD40 repeat-like	Tricorn protease N-terminal domain	1	1
ARM repeat	Toll/Interleukin receptor TIR domain	1	1
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
EF-hand	Ubiquitin-like	1	1
ARM repeat	beta-beta-alpha zinc fingers	1	1
ARM repeat	L domain-like	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	1	1
Ubiquitin-like	TPR-like	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	1	1
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
Plexin repeat	TSP-1 type 1 repeat	1	1
Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	1	1
SH2 domain	DNase I-like	1	1
ARM repeat	FYVE/PHD zinc finger	1	1
BRK domain-like	Bromodomain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Nucleotidyltransferase substrate binding subunit/domain	1	1
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	1	1
Sialidases	Sialidases	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
BRCT domain	WGR domain-like	1	1
TPR-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
GST C-terminal domain-like	Class II aaRS ABD-related	1	1
FnI-like domain	Leech antihemostatic proteins	1	1
LCCL domain	Galactose-binding domain-like	1	1
Thyroglobulin type-1 domain	alpha/beta-Hydrolases	1	1
E set domains	Protein kinase-like (PK-like)	1	1
Band 7/SPFH domain	SCP-like	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
ArfGap/RecO-like zinc finger	Ubiquitin-like	1	1
RING/U-box	Prefoldin	1	1
Metallo-dependent phosphatases	Formin homology 2 domain (FH2 domain)	1	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Ankyrin repeat	1	1
DPP6 N-terminal domain-like	ARM repeat	1	1
EF-hand	Rhomboid-like	1	1
EF-hand	DBL homology domain (DH-domain)	1	1
Spermadhesin, CUB domain	Cystine-knot cytokines	1	1
Actin-like ATPase domain	AF1104-like	1	1
beta-sandwich domain of Sec23/24	Eukaryotic type KH-domain (KH-domain type I)	1	1
Integrin beta tail domain	CalX-like	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
UBA-like	CCCH zinc finger	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
S13-like H2TH domain	Ran binding protein zinc finger-like	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Cysteine proteinases	1	1
EGF/Laminin	Tropomyosin	1	1
G protein-binding domain	G protein-binding domain	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Ankyrin repeat	SET domain	1	1
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Second domain of FERM	alpha-catenin/vinculin-like	1	1
Ran binding protein zinc finger-like	Cysteine proteinases	1	1
Protein kinase-like (PK-like)	Cyclin-like	1	1
PDZ domain-like	Nitric oxide (NO) synthase oxygenase domain	1	1
Six-hairpin glycosidases	Six-hairpin glycosidases	1	1
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	1	1
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	1	1
UBA-like	Hect, E3 ligase catalytic domain	1	1
P-loop containing nucleoside triphosphate hydrolases	LigT-like	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
PheT/TilS domain	Putative DNA-binding domain	1	1
Thioredoxin-like	FAD/NAD(P)-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Rudiment single hybrid motif	PurM N-terminal domain-like	1	1
beta-beta-alpha zinc fingers	RNA-binding domain, RBD	1	1
SMAD/FHA domain	Cap-Gly domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Ribonuclease H-like	1	1
ACP-like	alpha/beta-Hydrolases	1	1
SAND domain-like	HIT/MYND zinc finger-like	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	1	1
Immunoglobulin	GFP-like	1	1
Ubiquitin-like	alpha-catenin/vinculin-like	1	1
Cytidine deaminase-like	Cytidine deaminase-like	1	1
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	1	1
L domain-like	Ubiquitin-like	1	1
FabD/lysophospholipase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
N-terminal domain of MutM-like DNA repair proteins	Ran binding protein zinc finger-like	1	1
PDZ domain-like	PX domain	1	1
WD40 repeat-like	Soluble quinoprotein glucose dehydrogenase	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
CalX-like	Fibronectin type III	1	1
DNase I-like	SAM/Pointed domain	1	1
BRCA2 helical domain	Nucleic acid-binding proteins	1	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	1	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	1	1
RNA-binding domain, RBD	PAP/OAS1 substrate-binding domain	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
F-box domain	DBL homology domain (DH-domain)	1	1
Galactose-binding domain-like	Galactose oxidase, central domain	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
PX domain	TPR-like	1	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	1	1
CAD & PB1 domains	C-terminal domain of DFF45/ICAD (DFF-C domain)	1	1
HBS1-like domain	Translation proteins	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
FYVE/PHD zinc finger	HIT/MYND zinc finger-like	1	1
Starch-binding domain-like	(Phosphotyrosine protein) phosphatases II	1	1
FYVE/PHD zinc finger	PDZ domain-like	1	1
"Winged helix" DNA-binding domain	GroEL apical domain-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
TNF-like	Formin homology 2 domain (FH2 domain)	1	1
Tumor suppressor gene product Apc	ARM repeat	1	1
DEATH domain	WD40 repeat-like	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Tudor/PWWP/MBT	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Chaperone J-domain	Thioredoxin-like	1	1
Flavoproteins	Radical SAM enzymes	1	1
Multidrug efflux transporter AcrB transmembrane domain	Substrate-binding domain of HMG-CoA reductase	1	1
beta-beta-alpha zinc fingers	PAP/OAS1 substrate-binding domain	1	1