SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.


Domain combination pairs in Brachyspira pilosicoli 95/1000

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

  • For a list of unique full length architectures for this genome click here (can be slow).
Adjacent domain pairs graph

Graph of adjacent domain pairs.


Add or remove domain pairs

The links below permit the addition or removal of specific sets of domain combination pairs.


Jump to [ Top of page · Add/remove domain pairs · Domain combination pairs ]

Add or remove genomes

Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.

Add or remove genomes:
Include genomes:
Exclude genomes:


Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes ]

Domain combination pairs

485 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 1711
TPR-like TPR-like 159
Actin-like ATPase domain Actin-like ATPase domain 114
Ankyrin repeat Ankyrin repeat 98
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 92
Composite domain of metallo-dependent hydrolases Metallo-dependent hydrolases 94
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 83
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 71
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 75
P-loop containing nucleoside triphosphate hydrolases Translation proteins 65
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 62
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
GroES-like NAD(P)-binding Rossmann-fold domains 62
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 63
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 53
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 53
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 53
Thiolase-like Thiolase-like 51
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 53
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB transmembrane domain 53
Ribosomal protein S5 domain 2-like P-loop containing nucleoside triphosphate hydrolases 54
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 51
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB transmembrane domain 53
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 42
Nucleic acid-binding proteins Nucleic acid-binding proteins 43
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 41
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 44
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 43
Sensory domain-like Methyl-accepting chemotaxis protein (MCP) signaling domain 42
Alpha-L RNA-binding motif Pseudouridine synthase 42
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 42
TPR-like HCP-like 44
lambda repressor-like DNA-binding domains Periplasmic binding protein-like I 41
Ferritin-like Rubredoxin-like 41
PurM N-terminal domain-like PurM C-terminal domain-like 42
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 33
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 32
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 33
Methyl-accepting chemotaxis protein (MCP) signaling domain Methyl-accepting chemotaxis protein (MCP) signaling domain 32
Calcium ATPase, transmembrane domain M HAD-like 33
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 33
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 33
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphohistidine domain 32
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 32
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 33
Translation proteins EF-G C-terminal domain-like 32
Calcium ATPase, transduction domain A HAD-like 33
Lysozyme-like beta-lactamase/transpeptidase-like 32
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 32
CBS-domain pair FAD-binding/transporter-associated domain-like 32
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 31
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 33
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 32
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 32
EF-G C-terminal domain-like EF-G C-terminal domain-like 32
Class II aaRS and biotin synthetases Class II aaRS ABD-related 33
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 32
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 32
CheY-like Methylesterase CheB, C-terminal domain 21
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphoenolpyruvate/pyruvate domain 21
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
Nucleic acid-binding proteins Translation proteins SH3-like domain 22
Histidine-containing phosphotransfer domain, HPT domain ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheW-like 22
PDZ domain-like PDZ domain-like 22
CBS-domain pair MgtE membrane domain-like 21
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 21
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 21
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 21
GAF domain-like GAF domain-like 22
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 21
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 22
Phoshotransferase/anion transport protein PTS system IIB component-like 22
ThrRS/AlaRS common domain Class II aaRS and biotin synthetases 22
Serine metabolism enzymes domain ACT-like 22
Flavoproteins 4Fe-4S ferredoxins 21
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 22
Histidine-containing phosphotransfer domain, HPT domain Homodimeric domain of signal transducing histidine kinase 22
DNA methylase specificity domain DNA methylase specificity domain 21
Homeodomain-like Tetracyclin repressor-like, C-terminal domain 21
Alkaline phosphatase-like Concanavalin A-like lectins/glucanases 21
LysM domain LysM domain 22
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 22
PLP-binding barrel Alanine racemase C-terminal domain-like 21
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 22
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 22
cAMP-binding domain-like "Winged helix" DNA-binding domain 21
NagB/RpiA/CoA transferase-like NagB/RpiA/CoA transferase-like 21
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 21
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 21
Translation proteins Ribosomal protein S5 domain 2-like 21
Metallo-dependent phosphatases 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 22
Acyl-CoA dehydrogenase NM domain-like Acyl-CoA dehydrogenase C-terminal domain-like 22
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
TPR-like Protein prenylyltransferase 22
Chemotaxis receptor methyltransferase CheR, N-terminal domain S-adenosyl-L-methionine-dependent methyltransferases 21
MgtE N-terminal domain-like CBS-domain pair 21
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
2Fe-2S ferredoxin-like CO dehydrogenase ISP C-domain like 22
tRNA-binding arm Class II aaRS and biotin synthetases 21
Nucleic acid-binding proteins RuvA domain 2-like 22
MgtE N-terminal domain-like MgtE membrane domain-like 21
CheC-like Surface presentation of antigens (SPOA) 22
ACT-like ACT-like 22
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
CO dehydrogenase molybdoprotein N-domain-like Molybdenum cofactor-binding domain 22
HIT-like HIT-like 21
Homodimeric domain of signal transducing histidine kinase CheW-like 22
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 22
Glycoside hydrolase/deacetylase Families 57/38 glycoside transferase middle domain 22
Histidine-containing phosphotransfer domain, HPT domain CheW-like 22
Thioredoxin-like TPR-like 21
alpha-helical ferredoxin Nucleotide-binding domain 22
Translation proteins Translation proteins 11
PurM N-terminal domain-like PurM N-terminal domain-like 11
YjeF N-terminal domain-like Ribokinase-like 11
Methionine synthase domain Cobalamin (vitamin B12)-binding domain 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
HprK N-terminal domain-like PEP carboxykinase-like 11
CarD-like TRCF domain-like 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
Nucleotidylyl transferase Riboflavin kinase-like 11
Calcium-dependent phosphotriesterase Fibronectin type III 11
Acyl-CoA dehydrogenase C-terminal domain-like DHS-like NAD/FAD-binding domain 11
"Winged helix" DNA-binding domain NAD(P)-binding Rossmann-fold domains 11
PHP domain-like AF1531-like 11
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 11
CheY-binding domain of CheA Homodimeric domain of signal transducing histidine kinase 11
Nucleic acid-binding proteins BRCT domain 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
Calcium ATPase, transduction domain A Metal cation-transporting ATPase, ATP-binding domain N 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
PreATP-grasp domain Rudiment single hybrid motif 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
Carbamate kinase-like PUA domain-like 11
E set domains E set domains 11
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 11
GroEL-intermediate domain like GroEL apical domain-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
PurM C-terminal domain-like PurM C-terminal domain-like 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
Nqo1 FMN-binding domain-like alpha-helical ferredoxin 11
NAD(P)-binding Rossmann-fold domains UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
MetI-like MetI-like 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
NHL repeat vWA-like 11
Prokaryotic type I DNA topoisomerase Zinc beta-ribbon 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
Chaperone J-domain HSP40/DnaJ peptide-binding domain 11
N-terminal domain of MutM-like DNA repair proteins S13-like H2TH domain 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
FliG FliG 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD CoaB-like 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 11
HPr-like Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
PreATP-grasp domain FMN-linked oxidoreductases 11
PTS-regulatory domain, PRD PTS-regulatory domain, PRD 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) PRTase-like 11
P-loop containing nucleoside triphosphate hydrolases Hypothetical protein YjiA, C-terminal domain 11
PheT/TilS domain Putative DNA-binding domain 11
"Winged helix" DNA-binding domain NagB/RpiA/CoA transferase-like 11
FAD-binding/transporter-associated domain-like CO dehydrogenase flavoprotein C-terminal domain-like 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
Galactose mutarotase-like Glycosyl hydrolase domain 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Thioesterase/thiol ester dehydrase-isomerase Thioesterase/thiol ester dehydrase-isomerase 11
Obg GTP-binding protein N-terminal domain Radical SAM enzymes 11
HPr-like Phosphohistidine domain 11
Triger factor/SurA peptide-binding domain-like FKBP-like 11
YajQ-like YajQ-like 11
beta-lactamase/transpeptidase-like Penicillin-binding protein 2x (pbp-2x), c-terminal domain 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
GIY-YIG endonuclease RuvA domain 2-like 11
PurM C-terminal domain-like Class I glutamine amidotransferase-like 11
Adenine nucleotide alpha hydrolases-like DHS-like NAD/FAD-binding domain 11
PTS system fructose IIA component-like Phosphohistidine domain 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
Formyltransferase FMT C-terminal domain-like 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
Class II aaRS and biotin synthetases Translation proteins 11
Lysozyme-like LysM domain 11
LysM domain Duplicated hybrid motif 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
Aminopeptidase/glucanase lid domain Zn-dependent exopeptidases 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
Apolipoprotein A-I Bacterial hemolysins 11
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
Translation proteins ThrRS/AlaRS common domain 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
Nucleic acid-binding proteins PheT/TilS domain 11
Adenine nucleotide alpha hydrolases-like PheT/TilS domain 11
"Winged helix" DNA-binding domain LexA/Signal peptidase 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
Trypsin-like serine proteases PDZ domain-like 11
Ribosomal protein L6 Ribosomal protein L6 11
Galactose mutarotase-like (Trans)glycosidases 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
YbaK/ProRS associated domain Class II aaRS ABD-related 11
TPR-like NHL repeat 11
Nucleotidylyl transferase P-loop containing nucleoside triphosphate hydrolases 11
2Fe-2S ferredoxin-like CO dehydrogenase molybdoprotein N-domain-like 11
ISP domain Bet v1-like 11
MCP/YpsA-like "Winged helix" DNA-binding domain 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Phospholipase D/nuclease Phospholipase D/nuclease 11
SirA-like DsrEFH-like 11
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 11
Ribulose-phoshate binding barrel Nitrite and sulphite reductase 4Fe-4S domain-like 11
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 11
FMN-linked oxidoreductases alpha-helical ferredoxin 11
Nucleic acid-binding proteins GAD domain-like 11
Flavoproteins Flavoproteins 11
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 11
Dihydropteroate synthetase-like Cobalamin (vitamin B12)-binding domain 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
Chorismate mutase II ACT-like 11
PDZ domain-like ClpP/crotonase 11
HMA, heavy metal-associated domain HAD-like 11
CheY-like C-terminal effector domain of the bipartite response regulators 11
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 11
"Winged helix" DNA-binding domain Class II aaRS and biotin synthetases 11
Homocysteine S-methyltransferase Methionine synthase domain 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
Nucleic acid-binding proteins DNA helicase RuvA subunit, C-terminal domain 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
GroEL equatorial domain-like GroEL apical domain-like 11
Molybdenum cofactor biosynthesis proteins MoeA C-terminal domain-like 11
NagB/RpiA/CoA transferase-like Composite domain of metallo-dependent hydrolases 11
Aldolase AFP III-like domain 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
NagB/RpiA/CoA transferase-like Metallo-dependent hydrolases 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
Metal cation-transporting ATPase, ATP-binding domain N Calcium ATPase, transmembrane domain M 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
all-alpha NTP pyrophosphatases all-alpha NTP pyrophosphatases 11
Nucleotidylyl transferase tRNA-binding arm 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
(Trans)glycosidases Glycosyl hydrolase domain 11
Translation proteins PRC-barrel domain 11
Metallo-hydrolase/oxidoreductase Flavoproteins 11
PIN domain-like Ribonuclease H-like 11
CBS-domain pair Nucleotide cyclase 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
Galactose-binding domain-like beta-Galactosidase/glucuronidase domain 11
Formate/glycerate dehydrogenase catalytic domain-like Serine metabolism enzymes domain 11
Nucleotide-diphospho-sugar transferases Nucleotide-diphospho-sugar transferases 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Nucleic acid-binding proteins 11
DHH phosphoesterases DHH phosphoesterases 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Glucose permease domain IIB Duplicated hybrid motif 11
C-terminal domain of transcriptional repressors P-loop containing nucleoside triphosphate hydrolases 11
Nucleotide-diphospho-sugar transferases Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain 11
Calcium-dependent phosphotriesterase Calcium-dependent phosphotriesterase 11
GAF domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
MoeA N-terminal region -like MoeA C-terminal domain-like 11
Concanavalin A-like lectins/glucanases Fibronectin type III 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
P-loop containing nucleoside triphosphate hydrolases Radical SAM enzymes 11
Sigma3 and sigma4 domains of RNA polymerase sigma factors NagB/RpiA/CoA transferase-like 11
PTS system fructose IIA component-like Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
CheY-like Ribosomal protein S5 domain 2-like 11
"Winged helix" DNA-binding domain "Winged helix" DNA-binding domain 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
Putative DNA-binding domain CheY-like 11
beta-Galactosidase/glucuronidase domain (Trans)glycosidases 11
SufE/NifU Fe-S cluster assembly (FSCA) domain-like 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Aldolase post-HMGL domain-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase HSP90 C-terminal domain 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
2Fe-2S ferredoxin-like Molybdenum cofactor-binding domain 11
Homocysteine S-methyltransferase Cobalamin (vitamin B12)-binding domain 11
CO dehydrogenase ISP C-domain like CO dehydrogenase molybdoprotein N-domain-like 11
GAF domain-like Homodimeric domain of signal transducing histidine kinase 11
PTS system fructose IIA component-like HPr-like 11
Sialidases Sialidases 11
alpha-helical ferredoxin alpha-helical ferredoxin 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
"Winged helix" DNA-binding domain Iron-dependent repressor protein, dimerization domain 11
CheY-binding domain of CheA ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
TPR-like Calcium ATPase, transmembrane domain M 11
Acyl-CoA dehydrogenase NM domain-like Rubredoxin-like 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
Radical SAM enzymes Radical SAM enzymes 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
Ribonuclease H-like DNA/RNA polymerases 11
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 11
Dihydropteroate synthetase-like Methionine synthase domain 11
FMN-linked oxidoreductases Nucleotide-binding domain 11
Penicillin binding protein dimerisation domain Penicillin-binding protein 2x (pbp-2x), c-terminal domain 11
"Winged helix" DNA-binding domain Actin-like ATPase domain 11
DPP6 N-terminal domain-like TPR-like 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
Families 57/38 glycoside transferase middle domain Galactose mutarotase-like 11
Histidine-containing phosphotransfer domain, HPT domain CheY-binding domain of CheA 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
YrdC/RibB RibA-like 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
CheY-like P-loop containing nucleoside triphosphate hydrolases 11
"Winged helix" DNA-binding domain Chorismate lyase-like 11
P-loop containing nucleoside triphosphate hydrolases MOP-like 11
Metal cation-transporting ATPase, ATP-binding domain N HAD-like 11
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
Cation efflux protein transmembrane domain-like Cation efflux protein cytoplasmic domain-like 11
CheY-like PP2C-like 11
TPR-like vWA-like 11
Nucleic acid-binding proteins S-adenosyl-L-methionine-dependent methyltransferases 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Arabinanase/levansucrase/invertase Concanavalin A-like lectins/glucanases 11
Glutathione synthetase ATP-binding domain-like FMN-linked oxidoreductases 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
RuvA domain 2-like DNA helicase RuvA subunit, C-terminal domain 11
Ribosomal protein S5 domain 2-like HSP90 C-terminal domain 11
4Fe-4S ferredoxins Fe-only hydrogenase 11
cAMP-binding domain-like TPR-like 11
PTS-regulatory domain, PRD Phoshotransferase/anion transport protein 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 11
Aldolase Single hybrid motif 11
Zinc beta-ribbon DNA primase core 11
TPR-like Lysozyme-like 11
Acyl-CoA N-acyltransferases (Nat) SCP-like 11
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 11
Galactose-binding domain-like (Trans)glycosidases 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
NAD(P)-binding Rossmann-fold domains Serine metabolism enzymes domain 11
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
Carbamate kinase-like ACT-like 11
FucI/AraA N-terminal and middle domains FucI/AraA C-terminal domain-like 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
DNA clamp DNA clamp 11
S-adenosyl-L-methionine-dependent methyltransferases NAD(P)-binding Rossmann-fold domains 11
FAD/NAD-linked reductases, dimerisation (C-terminal) domain Rhodanese/Cell cycle control phosphatase 11
Nucleotidyltransferase Poly A polymerase C-terminal region-like 11
(Trans)glycosidases Cyclophilin-like 11
Glycoside hydrolase/deacetylase Galactose mutarotase-like 11
ALDH-like Dehydroquinate synthase-like 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
Chorismate mutase II Periplasmic binding protein-like II 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
P-loop containing nucleoside triphosphate hydrolases ACT-like 11
NAD(P)-binding Rossmann-fold domains TrkA C-terminal domain-like 11
Nucleic acid-binding proteins ArfGap/RecO-like zinc finger 11
FMN-binding split barrel Rubredoxin-like 11
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) Thioredoxin-like 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
GAF domain-like PP2C-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
Class II aaRS and biotin synthetases GAD domain-like 11
Nudix Homodimeric domain of signal transducing histidine kinase 11
PTS-regulatory domain, PRD PTS system IIB component-like 11
PK beta-barrel domain-like PK C-terminal domain-like 11
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
FMN-linked oxidoreductases FAD/NAD(P)-binding domain 11
PIN domain-like DNA/RNA polymerases 11
Nudix ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
MoeA N-terminal region -like Molybdenum cofactor biosynthesis proteins 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
NAD(P)-binding Rossmann-fold domains ACT-like 11
Acyl-CoA dehydrogenase C-terminal domain-like Rubredoxin-like 11
Apolipoprotein A-I Apolipoprotein A-I 11
F1F0 ATP synthase subunit C F1F0 ATP synthase subunit C 11
4'-phosphopantetheinyl transferase 4'-phosphopantetheinyl transferase 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
FAD/NAD(P)-binding domain Rhodanese/Cell cycle control phosphatase 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
DPP6 N-terminal domain-like alpha/beta-Hydrolases 11
Translation proteins "Winged helix" DNA-binding domain 11
CheY-like Homeodomain-like 11
Periplasmic binding protein-like II ACT-like 11
N-acetylmuramoyl-L-alanine amidase-like PGBD-like 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
JAB1/MPN domain P-loop containing nucleoside triphosphate hydrolases 11
DHS-like NAD/FAD-binding domain Rubredoxin-like 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
post-HMGL domain-like Single hybrid motif 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
Formate/glycerate dehydrogenase catalytic domain-like ACT-like 11
NAD(P)-binding Rossmann-fold domains 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
RuvA domain 2-like BRCT domain 11
Methyl-accepting chemotaxis protein (MCP) signaling domain Hemerythrin-like 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
Nucleotidylyl transferase Nucleic acid-binding proteins 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
PreATP-grasp domain Methylglyoxal synthase-like 11
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 11
P-loop containing nucleoside triphosphate hydrolases Homeodomain-like 11
Alpha-L RNA-binding motif S-adenosyl-L-methionine-dependent methyltransferases 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
ClpP/crotonase ClpP/crotonase 11
Zinc beta-ribbon Zinc beta-ribbon 11
Aspartate/glutamate racemase Aspartate/glutamate racemase 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
DeoB insert domain-like Alkaline phosphatase-like 11
CheY-binding domain of CheA CheW-like 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
ParB/Sulfiredoxin KorB DNA-binding domain-like 11
Aconitase iron-sulfur domain LeuD/IlvD-like 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
CO dehydrogenase ISP C-domain like Molybdenum cofactor-binding domain 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
Nucleotide-diphospho-sugar transferases Radical SAM enzymes 11
Class II aaRS and biotin synthetases YbaK/ProRS associated domain 11
Methylglyoxal synthase-like Cytidine deaminase-like 11
Acyl-CoA dehydrogenase NM domain-like DHS-like NAD/FAD-binding domain 11
Homocysteine S-methyltransferase Dihydropteroate synthetase-like 11
Carbon-nitrogen hydrolase Adenine nucleotide alpha hydrolases-like 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
RNase III domain-like dsRNA-binding domain-like 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 11
PurM N-terminal domain-like Class I glutamine amidotransferase-like 11
Ribulose-phoshate binding barrel PRTase-like 11
TrkA C-terminal domain-like TrkA C-terminal domain-like 11
PEP carboxykinase N-terminal domain PEP carboxykinase-like 11
Bacterial fluorinating enzyme, N-terminal domain Bacterial fluorinating enzyme, C-terminal domain 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
Domain of the SRP/SRP receptor G-proteins Signal peptide-binding domain 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III alpha-helical ferredoxin 11
6-phosphogluconate dehydrogenase C-terminal domain-like UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 11
CheY-like Nucleotide cyclase 11
Eukaryotic type KH-domain (KH-domain type I) HD-domain/PDEase-like 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
4Fe-4S ferredoxins 4Fe-4S ferredoxins 11
Elongation factor Ts (EF-Ts), dimerisation domain Elongation factor Ts (EF-Ts), dimerisation domain 11
PreATP-grasp domain PreATP-grasp domain 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
cAMP-binding domain-like cAMP-binding domain-like 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 11
Acyl-CoA N-acyltransferases (Nat) Acyl-CoA N-acyltransferases (Nat) 11
Methylated DNA-protein cysteine methyltransferase domain Methylated DNA-protein cysteine methyltransferase, C-terminal domain 11

Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes · Domain combination pairs ]