Domain combination pairs in Haloarcula hispanica N601

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

516 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	31	23
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	30	25
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	24	19
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	22	21
CheY-like	PYP-like sensor domain (PAS domain)	21	18
CheY-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	18	16
CheY-like	Homodimeric domain of signal transducing histidine kinase	17	15
PYP-like sensor domain (PAS domain)	GAF domain-like	17	16
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	17	11
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	15	13
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	14	2
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	13	4
CheY-like	GAF domain-like	13	12
GroES-like	NAD(P)-binding Rossmann-fold domains	12	3
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	12	11
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	12	5
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	12	3
Enolase N-terminal domain-like	Enolase C-terminal domain-like	11	1
"Winged helix" DNA-binding domain	GAF domain-like	10	1
P-loop containing nucleoside triphosphate hydrolases	MOP-like	9	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	9	5
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	9	1
Thiolase-like	Thiolase-like	9	2
Cyclin-like	Cyclin-like	8	1
Calcium ATPase, transduction domain A	HAD-like	8	7
Zinc beta-ribbon	Cyclin-like	8	1
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	8	2
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	8	2
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	7	2
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	7	2
Calcium ATPase, transmembrane domain M	HAD-like	7	6
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	7	6
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	7	6
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	7	4
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	7	1
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	6	4
HAMP domain-like	Methyl-accepting chemotaxis protein (MCP) signaling domain	6	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	6	5
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	6	1
TrkA C-terminal domain-like	TrkA C-terminal domain-like	6	4
GAF domain-like	GAF domain-like	6	6
Folate-binding domain	Aminomethyltransferase beta-barrel domain	6	3
HMA, heavy metal-associated domain	HAD-like	6	5
PurM N-terminal domain-like	PurM C-terminal domain-like	5	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	5	4
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	5	3
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	5	1
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	5	2
Sm-like ribonucleoproteins	Mechanosensitive channel protein MscS (YggB), C-terminal domain	5	4
Nucleic acid-binding proteins	Nucleic acid-binding proteins	5	5
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	5	2
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	5	4
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	4	3
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	4	1
PreATP-grasp domain	Rudiment single hybrid motif	4	2
"Winged helix" DNA-binding domain	TrmB C-terminal domain-like	4	2
Cupredoxins	Cupredoxins	4	2
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	4	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	4	2
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	4	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	4
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	3
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	4	1
(Trans)glycosidases	Glycosyl hydrolase domain	4	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	4	2
Actin-like ATPase domain	Actin-like ATPase domain	4	4
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	4	2
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	3	2
"Winged helix" DNA-binding domain	Phospholipase D/nuclease	3	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	3	3
Ribbon-helix-helix	ACT-like	3	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	3	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	3	2
Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, C-terminal domains	3	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	3	2
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	3	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	3	3
FAD-binding/transporter-associated domain-like	alpha-helical ferredoxin	3	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	2
GroEL-intermediate domain like	GroEL apical domain-like	3	2
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	3	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	3	2
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	3	2
FAD-linked reductases, C-terminal domain	Folate-binding domain	3	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	2
ClpP/crotonase	ClpP/crotonase	3	1
GroEL equatorial domain-like	GroEL apical domain-like	3	2
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	3	1
ADC-like	P-loop containing nucleoside triphosphate hydrolases	3	2
GroEL equatorial domain-like	GroEL-intermediate domain like	3	2
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	3	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	3	1
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	3	1
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	3	3
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	3	1
FAD/NAD(P)-binding domain	Folate-binding domain	3	1
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	2
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	3	2
FAD-linked oxidases, C-terminal domain	alpha-helical ferredoxin	3	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Mechanosensitive channel protein MscS (YggB), C-terminal domain	3	2
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	3	1
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	1
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	1
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
Hedgehog/intein (Hint) domain	Homing endonucleases	2	2
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	TK C-terminal domain-like	2	1
Rudiment single hybrid motif	Single hybrid motif	2	1
Translation proteins	ThrRS/AlaRS common domain	2	2
Nucleic acid-binding proteins	Translation proteins SH3-like domain	2	2
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	2	1
TSP type-3 repeat	TSP type-3 repeat	2	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	2	1
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	2	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	1
ADC-like	Cdc48 domain 2-like	2	1
ACT-like	ACT-like	2	2
PYP-like sensor domain (PAS domain)	Methyl-accepting chemotaxis protein (MCP) signaling domain	2	2
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	2	2
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	2	1
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	2	2
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	2
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	2	2
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	2	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	2	1
DNA clamp	DNA clamp	2	1
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	2
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Thiamin diphosphate-binding fold (THDP-binding)	2	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	2	1
Phospholipase D/nuclease	TrmB C-terminal domain-like	2	1
Thioredoxin-like	Six-hairpin glycosidases	2	2
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	2	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	2	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	2	2
Nucleic acid-binding proteins	DHH phosphoesterases	2	2
MetI-like	MetI-like	2	2
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	2	2
YegP-like	YegP-like	2	2
Voltage-gated potassium channels	TrkA C-terminal domain-like	2	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	2	1
FMN-binding split barrel	UbiD C-terminal domain-like	2	2
MurD-like peptide ligases, catalytic domain	Dihydropteroate synthetase-like	2	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	2	1
CBS-domain pair	CBS-domain pair	2	2
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	2	2
Glutamine synthetase/guanido kinase	GatB/YqeY motif	2	2
PreATP-grasp domain	Single hybrid motif	2	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	2	1
"Winged helix" DNA-binding domain	Nucleotidyltransferase	2	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	2	2
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	2	2
Phospholipase D/nuclease	Phospholipase D/nuclease	2	2
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	2	1
6-phosphogluconate dehydrogenase C-terminal domain-like	ClpP/crotonase	2	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	2	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	2
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	2	2
NAD(P)-binding Rossmann-fold domains	ClpP/crotonase	2	1
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	2	2
GAF domain-like	Sigma3 and sigma4 domains of RNA polymerase sigma factors	2	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	2	2
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	2	2
Nqo5-like	HydB/Nqo4-like	2	1
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	2	2
Translational machinery components	L30e-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	2	2
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	2
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	2	2
NAD(P)-binding Rossmann-fold domains	DHH phosphoesterases	2	2
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	2	1
Bacterial fluorinating enzyme, N-terminal domain	Bacterial fluorinating enzyme, C-terminal domain	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	2	1
RuvA domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	2
CBS-domain pair	FAD-binding/transporter-associated domain-like	2	1
Class I glutamine amidotransferase-like	vWA-like	2	2
lambda repressor-like DNA-binding domains	AraD/HMP-PK domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	2	2
Single hybrid motif	CoA-dependent acyltransferases	2	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	2	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	2
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	2	1
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
Pre-PUA domain	PUA domain-like	2	2
tRNA-guanine transglycosylase	Pre-PUA domain	2	2
MurD-like peptide ligases, peptide-binding domain	Dihydropteroate synthetase-like	2	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
CBS-domain pair	Thioesterase/thiol ester dehydrase-isomerase	2	1
Rhodanese/Cell cycle control phosphatase	Metallo-hydrolase/oxidoreductase	2	1
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	2	1
tRNA-guanine transglycosylase	Uracil-DNA glycosylase-like	1	1
MFS general substrate transporter	MFS general substrate transporter	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
Molybdenum cofactor biosynthesis proteins	Periplasmic binding protein-like II	1	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Nucleic acid-binding proteins	1	1
Serine metabolism enzymes domain	ACT-like	1	1
Translation proteins	Ribosomal protein S5 domain 2-like	1	1
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	1	1
PRTase-like	PRTase-like	1	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Glutamine synthetase/guanido kinase	GAD domain-like	1	1
PhoU-like	TrkA C-terminal domain-like	1	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	1	1
Oxidoreductase molybdopterin-binding domain	E set domains	1	1
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	1	1
MoeA N-terminal region -like	Periplasmic binding protein-like II	1	1
Cytochrome c oxidase subunit I-like	Cytochrome c oxidase subunit III-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	1	1
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	1	1
PYP-like sensor domain (PAS domain)	Sigma3 and sigma4 domains of RNA polymerase sigma factors	1	1
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Radical SAM enzymes	PsbU/PolX domain-like	1	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Histidine-containing phosphotransfer domain, HPT domain	Homodimeric domain of signal transducing histidine kinase	1	1
Class I glutamine amidotransferase-like	Starch-binding domain-like	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
CheY-binding domain of CheA	CheW-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
MoeA C-terminal domain-like	Periplasmic binding protein-like II	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
Periplasmic binding protein-like I	Periplasmic binding protein-like I	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
Hemerythrin-like	Acetyl-CoA synthetase-like	1	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleotide-diphospho-sugar transferases	Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
Invasin/intimin cell-adhesion fragments	PKD domain	1	1
Nucleic acid-binding proteins	lambda repressor-like DNA-binding domains	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	1	1
Nucleic acid-binding proteins	Homing endonucleases	1	1
GatD N-terminal domain-like	Glutaminase/Asparaginase	1	1
CbiG N-terminal domain-like	CobE/GbiG C-terminal domain-like	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
"Winged helix" DNA-binding domain	Riboflavin kinase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	1	1
Prokaryotic type KH domain (KH-domain type II)	Metallo-hydrolase/oxidoreductase	1	1
Starch-binding domain-like	PHP domain-like	1	1
HAD-like	Nudix	1	1
tRNA-intron endonuclease catalytic domain-like	tRNA-intron endonuclease catalytic domain-like	1	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
PDZ domain-like	PDZ domain-like	1	1
MalF N-terminal region-like	MetI-like	1	1
Uracil-DNA glycosylase-like	Pre-PUA domain	1	1
Chemotaxis receptor methyltransferase CheR, N-terminal domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Type I dockerin domain	vWA-like	1	1
Hypothetical protein AF0491, middle domain	EF-G C-terminal domain-like	1	1
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	1	1
Rad51 N-terminal domain-like	Ribosomal protein L32e	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
Staphylococcal nuclease	Lamin A/C globular tail domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Acyl-CoA N-acyltransferases (Nat)	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	1	1
TGS-like	Class II aaRS ABD-related	1	1
Globin-like	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
Aminoacid dehydrogenase-like, N-terminal domain	Isocitrate/Isopropylmalate dehydrogenase-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease N-terminal domain-like	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
PK C-terminal domain-like	Phosphohistidine domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	1	1
Nucleic acid-binding proteins	RuvA domain 2-like	1	1
ITPase-like	ITPase-like	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
GroES-like	GroES-like	1	1
Acyl-CoA N-acyltransferases (Nat)	SCP-like	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleotidyltransferase	PHP domain-like	1	1
PPK N-terminal domain-like	Phospholipase D/nuclease	1	1
HAMP domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
PK beta-barrel domain-like	Phosphohistidine domain	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphohistidine domain	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
GIY-YIG endonuclease	RuvA domain 2-like	1	1
Chaperone J-domain	2Fe-2S ferredoxin-like	1	1
Six-hairpin glycosidases	Six-hairpin glycosidases	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	1	1
Nucleic acid-binding proteins	Hedgehog/intein (Hint) domain	1	1
RuvA domain 2-like	BRCT domain	1	1
CheC-like	CheC-like	1	1
Galactose-binding domain-like	Galactose-binding domain-like	1	1
"Winged helix" DNA-binding domain	Acyl-CoA N-acyltransferases (Nat)	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
Tropomyosin	Smc hinge domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	1	1
Smc hinge domain	Myosin rod fragments	1	1
NAD(P)-binding Rossmann-fold domains	Glutathione synthetase ATP-binding domain-like	1	1
Subtilisin-like	PKD domain	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	1	1
Homing endonucleases	lambda repressor-like DNA-binding domains	1	1
PA domain	Zn-dependent exopeptidases	1	1
Periplasmic binding protein-like II	Periplasmic binding protein-like II	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
Nucleotidylyl transferase	Ribosomal protein L25-like	1	1
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	1	1
Thioredoxin-like	GST C-terminal domain-like	1	1
Type I dockerin domain	TSP type-3 repeat	1	1
Respiratory nitrate reductase 1 gamma chain	alpha-helical ferredoxin	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	1	1
GAD domain-like	GatB/YqeY motif	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	1	1
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	1	1
"Winged helix" DNA-binding domain	MOP-like	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Class I glutamine amidotransferase-like	Concanavalin A-like lectins/glucanases	1	1
CBS-domain pair	ParB/Sulfiredoxin	1	1
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	1	1
Heme-dependent peroxidases	Heme-dependent peroxidases	1	1
Cna protein B-type domain	Carboxypeptidase regulatory domain-like	1	1
2Fe-2S ferredoxin-like	ADC-like	1	1
PPK N-terminal domain-like	PHP14-like	1	1
CheY-binding domain of CheA	Homodimeric domain of signal transducing histidine kinase	1	1
Uracil-DNA glycosylase-like	PUA domain-like	1	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	1	1
4Fe-4S ferredoxins	4Fe-4S ferredoxins	1	1
Six-hairpin glycosidases	Galactose mutarotase-like	1	1
Hedgehog/intein (Hint) domain	lambda repressor-like DNA-binding domains	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
Restriction endonuclease-like	RuvA domain 2-like	1	1
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	1	1
TATA-box binding protein-like	TATA-box binding protein-like	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Chelatase	Thioredoxin-like	1	1
"Winged helix" DNA-binding domain	NagB/RpiA/CoA transferase-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
Translation proteins	EF-G C-terminal domain-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
ACT-like	Formyltransferase	1	1
Ribokinase-like	AraD/HMP-PK domain-like	1	1
DNA polymerase beta, N-terminal domain-like	Sec63 N-terminal domain-like	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Nucleic acid-binding proteins	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Chelatase	Chelatase	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Molybdopterin synthase subunit MoaE	1	1
Homing endonucleases	P-loop containing nucleoside triphosphate hydrolases	1	1
Galactose-binding domain-like	CBD9-like	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
Histidine-containing phosphotransfer domain, HPT domain	CheW-like	1	1
AN1-like Zinc finger	Rhomboid-like	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
LEA14-like	LEA14-like	1	1
Invasin/intimin cell-adhesion fragments	Cna protein B-type domain	1	1
Nucleic acid-binding proteins	FomD-like	1	1
CheY-binding domain of CheA	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheW-like	1	1
PHP14-like	Phospholipase D/nuclease	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphoenolpyruvate/pyruvate domain	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	1	1
Formyltransferase	Cytidine deaminase-like	1	1
TSP type-3 repeat	vWA-like	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Pseudouridine synthase	PUA domain-like	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
THUMP domain-like	Adenine nucleotide alpha hydrolases-like	1	1
TSP type-3 repeat	"Winged helix" DNA-binding domain	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Iron-dependent repressor protein, dimerization domain	C-terminal domain of transcriptional repressors	1	1
NAD(P)-binding Rossmann-fold domains	Isocitrate/Isopropylmalate dehydrogenase-like	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
Tricorn protease N-terminal domain	alpha/beta-Hydrolases	1	1
Galactose-binding domain-like	(Trans)glycosidases	1	1
Class I glutamine amidotransferase-like	Arabinanase/levansucrase/invertase	1	1
Actin-like ATPase domain	Protein kinase-like (PK-like)	1	1
Homing endonucleases	Homing endonucleases	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Class I glutamine amidotransferase-like	PHP domain-like	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	1	1
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	1	1
Succinyl-CoA synthetase domains	Succinyl-CoA synthetase domains	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
lambda repressor-like DNA-binding domains	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
Carbamate kinase-like	ACT-like	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
alpha/beta-Hydrolases	Rad51 N-terminal domain-like	1	1
Ribonuclease H-like	DNA/RNA polymerases	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
Invasin/intimin cell-adhesion fragments	Carboxypeptidase regulatory domain-like	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	1	1
Nudix	NagB/RpiA/CoA transferase-like	1	1
DNA breaking-rejoining enzymes	GAF domain-like	1	1
Histidine-containing phosphotransfer domain, HPT domain	CheY-binding domain of CheA	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
Sec63 N-terminal domain-like	Nucleotidyltransferase	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
DnaJ/Hsp40 cysteine-rich domain	Pseudouridine synthase	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
Tropomyosin	Myosin rod fragments	1	1
Nitrous oxide reductase, N-terminal domain	Cupredoxins	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Periplasmic binding protein-like II	1	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	1	1
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	1	1
NAD(P)-binding Rossmann-fold domains	Siroheme synthase middle domains-like	1	1
NagB/RpiA/CoA transferase-like	alpha-helical ferredoxin	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	1	1
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	1	1
TSP type-3 repeat	Metalloproteases ("zincins"), catalytic domain	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
DNA polymerase beta, N-terminal domain-like	PHP domain-like	1	1
Protein kinase-like (PK-like)	SMAD/FHA domain	1	1
Initiation factor IF2/eIF5b, domain 3	Translation proteins	1	1
Histidine-containing phosphotransfer domain, HPT domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
PhoU-like	PhoU-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Periplasmic binding protein-like II	GlnB-like	1	1
FYSH domain	EF-G C-terminal domain-like	1	1
PIN domain-like	Prokaryotic type KH domain (KH-domain type II)	1	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	1	1
lambda repressor-like DNA-binding domains	CBS-domain pair	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	1	1
Homodimeric domain of signal transducing histidine kinase	CheW-like	1	1
"Winged helix" DNA-binding domain	TrkA C-terminal domain-like	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease catalytic domain-like	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
NosL/MerB-like	Pectin lyase-like	1	1
CheY-like	Sigma3 and sigma4 domains of RNA polymerase sigma factors	1	1
Periplasmic binding protein-like II	ACT-like	1	1
Thiolase-like	Nucleic acid-binding proteins	1	1
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	1	1
4Fe-4S ferredoxins	ADC-like	1	1
Sec63 N-terminal domain-like	PHP domain-like	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	1	1
tRNA-guanine transglycosylase	PUA domain-like	1	1
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	1	1
P-loop containing nucleoside triphosphate hydrolases	HprK N-terminal domain-like	1	1
CheY-like	Methylesterase CheB, C-terminal domain	1	1
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	1	1
Zinc-binding domain of translation initiation factor 2 beta	Nucleic acid-binding proteins	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	1	1
GIY-YIG endonuclease	C-terminal UvrC-binding domain of UvrB	1	1
Hedgehog/intein (Hint) domain	P-loop containing nucleoside triphosphate hydrolases	1	1
PIN domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Glutathione synthetase ATP-binding domain-like	Acid proteases	1	1

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