Domain combination pairs in Corynebacterium efficiens YS-314

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

546 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	35	16
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	13	4
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	11	6
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	11	3
CheY-like	C-terminal effector domain of the bipartite response regulators	10	2
GroES-like	NAD(P)-binding Rossmann-fold domains	9	3
Calcium ATPase, transduction domain A	HAD-like	9	5
Actin-like ATPase domain	Actin-like ATPase domain	8	4
HAD-like	Calcium ATPase, transmembrane domain M	8	4
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	8	4
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	8	3
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	8	6
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	7	3
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	7	5
Thiolase-like	Thiolase-like	7	2
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	7	5
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	7	1
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	7	3
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	6	3
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	6	4
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	6	2
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	6	2
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	6	1
"Winged helix" DNA-binding domain	GntR ligand-binding domain-like	6	1
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	6	6
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	5	4
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	5	3
ClpP/crotonase	ClpP/crotonase	5	1
HAMP domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	1
"Winged helix" DNA-binding domain	GAF domain-like	5	1
PreATP-grasp domain	Rudiment single hybrid motif	5	3
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like I	5	2
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	5	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	5	4
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	5	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	4	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	4	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	3
CBS-domain pair	FAD-binding/transporter-associated domain-like	4	1
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	2
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	4	3
Translation proteins	EF-G C-terminal domain-like	4	3
MoeA N-terminal region -like	MoeA C-terminal domain-like	3	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	3	2
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	3	2
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	3	2
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	3	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	3	3
Metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	3	3
PurM N-terminal domain-like	PurM C-terminal domain-like	3	2
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	3	3
Ferredoxin reductase-like, C-terminal NADP-linked domain	2Fe-2S ferredoxin-like	3	2
FabD/lysophospholipase-like	Thiolase-like	3	2
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	3	1
Rudiment single hybrid motif	Single hybrid motif	3	3
(Trans)glycosidases	Glycosyl hydrolase domain	3	3
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	3	2
Riboflavin synthase domain-like	2Fe-2S ferredoxin-like	3	2
Alpha-L RNA-binding motif	Pseudouridine synthase	3	1
Nucleic acid-binding proteins	RuvA domain 2-like	3	3
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	3	3
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	3	2
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	3	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	3	3
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	3	2
"Winged helix" DNA-binding domain	Chorismate lyase-like	3	1
E set domains	(Trans)glycosidases	3	3
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	3	1
P-loop containing nucleoside triphosphate hydrolases	MOP-like	3	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	3	2
DNA methylase specificity domain	DNA methylase specificity domain	3	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	3	3
Aldolase	post-HMGL domain-like	3	3
L30e-like	alpha/beta knot	3	2
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	3	2
Ribosomal protein S5 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	3	3
"Winged helix" DNA-binding domain	NagB/RpiA/CoA transferase-like	3	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	2	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	2	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	1
MFS general substrate transporter	MFS general substrate transporter	2	2
E set domains	Glycosyl hydrolase domain	2	2
Inosine monophosphate dehydrogenase (IMPDH)	Thiolase-like	2	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
MurCD N-terminal domain	MurD-like peptide ligases, catalytic domain	2	1
Origin of replication-binding domain, RBD-like	P-loop containing nucleoside triphosphate hydrolases	2	2
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	2	2
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	2	1
MurCD N-terminal domain	MurD-like peptide ligases, peptide-binding domain	2	1
Nucleic acid-binding proteins	Nucleic acid-binding proteins	2	2
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
Penicillin binding protein dimerisation domain	beta-lactamase/transpeptidase-like	2	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal effector domain of the bipartite response regulators	2	1
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	2	2
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
P-loop containing nucleoside triphosphate hydrolases	TPR-like	2	1
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	2	2
NAD(P)-binding Rossmann-fold domains	ACT-like	2	2
Nucleic acid-binding proteins	Translation proteins SH3-like domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	2	1
Inosine monophosphate dehydrogenase (IMPDH)	Thioesterase/thiol ester dehydrase-isomerase	2	1
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	2	2
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	2	2
Lysozyme-like	beta-lactamase/transpeptidase-like	2	2
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	2	2
NAD(P)-binding Rossmann-fold domains	Thiolase-like	2	1
Thioesterase/thiol ester dehydrase-isomerase	Thiolase-like	2	1
Iron-dependent repressor protein, dimerization domain	C-terminal domain of transcriptional repressors	2	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	2	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	2	1
Nucleotidyltransferase	HD-domain/PDEase-like	2	2
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	2	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	2	2
tRNA-binding arm	Class II aaRS and biotin synthetases	2	1
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	2	1
MgtE N-terminal domain-like	CBS-domain pair	2	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	2	1
Trypsin-like serine proteases	PDZ domain-like	2	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	2	2
ISP domain	Bet v1-like	2	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	2	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	2	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	2	1
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	2	2
PH0987 N-terminal domain-like	Cyclophilin-like	2	2
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	2	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
Thioesterase/thiol ester dehydrase-isomerase	NAD(P)-binding Rossmann-fold domains	2	1
GroEL equatorial domain-like	GroEL apical domain-like	2	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Ribonuclease H-like	BRCT domain	2	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	2	2
Bet v1-like	NAD(P)-binding Rossmann-fold domains	2	2
Cupredoxins	Cupredoxins	2	2
FabD/lysophospholipase-like	FabD/lysophospholipase-like	2	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	2	1
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	2	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	2	1
FabD/lysophospholipase-like	Thioesterase/thiol ester dehydrase-isomerase	2	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	1
TPR-like	C-terminal effector domain of the bipartite response regulators	2	1
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	2	2
cAMP-binding domain-like	"Winged helix" DNA-binding domain	2	1
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	2	2
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	2	1
PreATP-grasp domain	Single hybrid motif	2	2
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	2	2
Homeodomain-like	Homeodomain-like	2	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	2	2
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	2	1
FabD/lysophospholipase-like	Inosine monophosphate dehydrogenase (IMPDH)	2	1
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	2	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	2	2
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	2	1
ACT-like	ACT-like	2	2
Inosine monophosphate dehydrogenase (IMPDH)	NAD(P)-binding Rossmann-fold domains	2	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
ABC transporter transmembrane region	ABC transporter transmembrane region	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
FAD/NAD(P)-binding domain	ISP domain	1	1
Sensory domain-like	Sporulation response regulatory protein Spo0B	1	1
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	1	1
RuvA domain 2-like	BRCT domain	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	1	1
ACP-like	Thiolase-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Putative DNA-binding domain	Antibiotic binding domain of TipA-like multidrug resistance regulators	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
RuvA domain 2-like	DNA helicase RuvA subunit, C-terminal domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
CarD-like	TRCF domain-like	1	1
post-HMGL domain-like	Single hybrid motif	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	1	1
GroES-like	GroES-like	1	1
Zinc beta-ribbon	DNA primase core	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	1	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	1	1
GAF domain-like	C-terminal effector domain of the bipartite response regulators	1	1
P-loop containing nucleoside triphosphate hydrolases	ACT-like	1	1
Ribokinase-like	Heme oxygenase-like	1	1
MgtE N-terminal domain-like	MgtE membrane domain-like	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	1	1
"Winged helix" DNA-binding domain	LexA/Signal peptidase	1	1
PRC-barrel domain	CBS-domain pair	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
HD-domain/PDEase-like	TGS-like	1	1
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
CoA-dependent acyltransferases	Acyl-CoA N-acyltransferases (Nat)	1	1
FAD-binding/transporter-associated domain-like	alpha-helical ferredoxin	1	1
Single hybrid motif	CoA-dependent acyltransferases	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	P-loop containing nucleoside triphosphate hydrolases	1	1
Globin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Translation proteins	PRC-barrel domain	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
Protein kinase-like (PK-like)	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	1	1
Ribonuclease H-like	RuvA domain 2-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	1	1
NTF2-like	FAD/NAD(P)-binding domain	1	1
ParB/Sulfiredoxin	KorB DNA-binding domain-like	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
MFS general substrate transporter	P-loop containing nucleoside triphosphate hydrolases	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
N-terminal domain of DnaB helicase	P-loop containing nucleoside triphosphate hydrolases	1	1
cAMP-binding domain-like	Nucleotidyltransferase	1	1
HAD-like	Six-hairpin glycosidases	1	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	1	1
5' to 3' exonuclease, C-terminal subdomain	Ribonuclease H-like	1	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Aldolase	Single hybrid motif	1	1
HAMP domain-like	Nucleotide cyclase	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
PreATP-grasp domain	post-HMGL domain-like	1	1
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	1	1
P-loop containing nucleoside triphosphate hydrolases	CarD-like	1	1
TGS-like	ACT-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
Metallo-hydrolase/oxidoreductase	Rhodanese/Cell cycle control phosphatase	1	1
ACP-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
Ribonuclease H-like	Phosphoglycerate mutase-like	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
Sporulation response regulatory protein Spo0B	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
MetI-like	MetI-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	1	1
Glutathione synthetase ATP-binding domain-like	Aldolase	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
RuvA domain 2-like	RuvA domain 2-like	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	1	1
PheT/TilS domain	Putative DNA-binding domain	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
FAD-linked oxidases, C-terminal domain	alpha-helical ferredoxin	1	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	1	1
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
NAD(P)-binding Rossmann-fold domains	ClpP/crotonase	1	1
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	1	1
PH0987 N-terminal domain-like	Single hybrid motif	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
Periplasmic binding protein-like II	vWA-like	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	1	1
CBS-domain pair	Nucleotidyltransferase	1	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	1	1
YrdC/RibB	RibA-like	1	1
Class I glutamine amidotransferase-like	ADC synthase	1	1
PreATP-grasp domain	Aldolase	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
Thiamin phosphate synthase	Ribokinase-like	1	1
Cyclophilin-like	Single hybrid motif	1	1
RNase III domain-like	dsRNA-binding domain-like	1	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	1	1
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	1	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	1	1
Acetyl-CoA synthetase-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
FabD/lysophospholipase-like	alpha/beta-Hydrolases	1	1
Lamin A/C globular tail domain	Thermostable phytase (3-phytase)	1	1
Nucleic acid-binding proteins	Anticodon-binding domain of PheRS	1	1
Nucleotidyltransferase	ACT-like	1	1
"Winged helix" DNA-binding domain	Actin-like ATPase domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
E set domains	alpha/beta-Hydrolases	1	1
Protein kinase-like (PK-like)	TPR-like	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
Thiolase-like	alpha/beta-Hydrolases	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
Cytidine deaminase-like	Dihydrofolate reductase-like	1	1
GroEL equatorial domain-like	GroEL equatorial domain-like	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
Aspartate/glutamate racemase	Aspartate/glutamate racemase	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	1	1
cAMP-binding domain-like	CBS-domain pair	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	1	1
Tetrapyrrole methylase	HemD-like	1	1
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	1	1
Rudiment single hybrid motif	Cyclophilin-like	1	1
DinB/YfiT-like putative metalloenzymes	SCP-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	ClpP/crotonase	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	1	1
Nucleic acid-binding proteins	Putative DNA-binding domain	1	1
Translation proteins	Initiation factor IF2/eIF5b, domain 3	1	1
Nucleic acid-binding proteins	Prokaryotic type KH domain (KH-domain type II)	1	1
Acetyl-CoA synthetase-like	Acyl-CoA dehydrogenase NM domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
PreATP-grasp domain	PH0987 N-terminal domain-like	1	1
Periplasmic binding protein-like II	ACT-like	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Single hybrid motif	Single hybrid motif	1	1
GAF domain-like	PP2C-like	1	1
Ribonuclease H-like	DNA/RNA polymerases	1	1
post-HMGL domain-like	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
Galactose-binding domain-like	(Trans)glycosidases	1	1
GIY-YIG endonuclease	C-terminal UvrC-binding domain of UvrB	1	1
PGBD-like	PGBD-like	1	1
Thioredoxin-like	GST C-terminal domain-like	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphoenolpyruvate/pyruvate domain	1	1
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	1	1
Galactose mutarotase-like	Six-hairpin glycosidases	1	1
Periplasmic binding protein-like II	GlnB-like	1	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
Tex N-terminal region-like	Ribonuclease H-like	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
Glucose permease domain IIB	Duplicated hybrid motif	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
Putative DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
Nucleotidylyl transferase	Riboflavin kinase-like	1	1
5' to 3' exonuclease, C-terminal subdomain	DNA/RNA polymerases	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	ACT-like	1	1
Thiamin phosphate synthase	Heme oxygenase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	1	1
GreA transcript cleavage protein, N-terminal domain	FKBP-like	1	1
Cytochrome c	Cytochrome c	1	1
HMA, heavy metal-associated domain	HAD-like	1	1
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
S-adenosyl-L-methionine-dependent methyltransferases	DNA methylase specificity domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Nucleic acid-binding proteins	ArfGap/RecO-like zinc finger	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Transcription factor NusA, N-terminal domain	Prokaryotic type KH domain (KH-domain type II)	1	1
Nucleic acid-binding proteins	DNA helicase RuvA subunit, C-terminal domain	1	1
Lamin A/C globular tail domain	Lamin A/C globular tail domain	1	1
E set domains	E set domains	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
PIN domain-like	DNA/RNA polymerases	1	1
Putative DNA-binding domain	Anticodon-binding domain of PheRS	1	1
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	GntR ligand-binding domain-like	1	1
Rudiment single hybrid motif	post-HMGL domain-like	1	1
Transcription factor NusA, N-terminal domain	Nucleic acid-binding proteins	1	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	1	1
YbaK/ProRS associated domain	Class II aaRS ABD-related	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
Nucleotidyltransferase substrate binding subunit/domain	Nucleotidyltransferase substrate binding subunit/domain	1	1
Nucleotidyltransferase	TGS-like	1	1
Pseudouridine synthase	PUA domain-like	1	1
AhpD-like	AhpD-like	1	1
Dihydropteroate synthetase-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
Tetrapyrrole methylase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Zinc beta-ribbon	Prokaryotic SH3-related domain	1	1
Urease metallochaperone UreE, N-terminal domain	Urease metallochaperone UreE, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	1	1
Resolvase-like	Homeodomain-like	1	1
MalF N-terminal region-like	MetI-like	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
Translation proteins	Translation proteins	1	1
Globin-like	Riboflavin synthase domain-like	1	1
Nucleotidyltransferase	Nucleotidyltransferase substrate binding subunit/domain	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	Rhodanese/Cell cycle control phosphatase	1	1
Sensory domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Class I glutamine amidotransferase-like	Homeodomain-like	1	1
beta-lactamase/transpeptidase-like	SpoIIaa-like	1	1
ACT-like	HAD-like	1	1
Xylose isomerase-like	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
PUA domain-like	alpha/beta knot	1	1
CheY-like	"Winged helix" DNA-binding domain	1	1
Nucleotidyltransferase	Nucleotidyltransferase	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
alpha/beta-Hydrolases	OsmC-like	1	1
CoA-dependent acyltransferases	Thiamin diphosphate-binding fold (THDP-binding)	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Cyclophilin-like	Cyclophilin-like	1	1
ACP-like	Trimeric LpxA-like enzymes	1	1
Eukaryotic type KH-domain (KH-domain type I)	Nucleic acid-binding proteins	1	1
Glutathione synthetase ATP-binding domain-like	PH0987 N-terminal domain-like	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	1	1
PheT/TilS domain	Anticodon-binding domain of PheRS	1	1
Class II aaRS and biotin synthetases	C-terminal domain of transcriptional repressors	1	1
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	1	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
ACP-like	FabD/lysophospholipase-like	1	1
HAD-like	Galactose mutarotase-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
FAD-binding/transporter-associated domain-like	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	1	1
FAD/NAD(P)-binding domain	Alanine racemase C-terminal domain-like	1	1
FAD/NAD(P)-binding domain	Rhodanese/Cell cycle control phosphatase	1	1
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	1	1
HD-domain/PDEase-like	ACT-like	1	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	1	1
Nudix	"Winged helix" DNA-binding domain	1	1
Acetyl-CoA synthetase-like	ACP-like	1	1
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	1	1
FAD/NAD(P)-binding domain	PLP-binding barrel	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
Carbamate kinase-like	ACT-like	1	1
Glutathione synthetase ATP-binding domain-like	Cyclophilin-like	1	1
Lamin A/C globular tail domain	DNase I-like	1	1
GroEL equatorial domain-like	GroEL-intermediate domain like	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Nudix	Phosphoglycerate mutase-like	1	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
PGBD-like	Zn-dependent exopeptidases	1	1
Carbamate kinase-like	PUA domain-like	1	1
"Winged helix" DNA-binding domain	C-terminal domain of arginine repressor	1	1
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	1	1
alpha-helical ferredoxin	Nucleotide-binding domain	1	1
2Fe-2S ferredoxin-like	GntR ligand-binding domain-like	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	1	1
FAD-linked oxidoreductase	ALDH-like	1	1
Formyltransferase	FMT C-terminal domain-like	1	1
YojJ-like	RuvA domain 2-like	1	1
PIN domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
ALDH-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
Class II aaRS and biotin synthetases	YbaK/ProRS associated domain	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
GroEL-intermediate domain like	GroEL apical domain-like	1	1
MCP/YpsA-like	"Winged helix" DNA-binding domain	1	1
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	1	1
ACP-like	alpha/beta-Hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	TrpR-like	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Nucleotide-diphospho-sugar transferases	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
PreATP-grasp domain	Cyclophilin-like	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
Trigger factor ribosome-binding domain	FKBP-like	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	1	1
Phospholipase D/nuclease	Phospholipase D/nuclease	1	1
Rudiment single hybrid motif	Aldolase	1	1
Phoshotransferase/anion transport protein	PTS system IIB component-like	1	1
Nucleotidylyl transferase	tRNA-binding arm	1	1
Activating enzymes of the ubiquitin-like proteins	Rhodanese/Cell cycle control phosphatase	1	1
Serine metabolism enzymes domain	ACT-like	1	1
Nucleic acid-binding proteins	PheT/TilS domain	1	1
RmlC-like cupins	NAD(P)-binding Rossmann-fold domains	1	1
NTF2-like	beta-lactamase/transpeptidase-like	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
DNA clamp	DNA clamp	1	1
ACT-like	Formyltransferase	1	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
lambda integrase-like, N-terminal domain	DNA breaking-rejoining enzymes	1	1
GIY-YIG endonuclease	RuvA domain 2-like	1	1
FKBP-like	Triger factor/SurA peptide-binding domain-like	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	1	1
Translation proteins	Ribosomal protein S5 domain 2-like	1	1
Rudiment single hybrid motif	PH0987 N-terminal domain-like	1	1
PDZ domain-like	Ribosomal protein S5 domain 2-like	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Ribonuclease H-like	HRDC-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphohistidine domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
NTF2-like	Penicillin binding protein dimerisation domain	1	1
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	1	1
ACP-like	ACP-like	1	1
Riboflavin synthase domain-like	GntR ligand-binding domain-like	1	1
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	1	1
CBS-domain pair	MgtE membrane domain-like	1	1
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	1	1
Alpha-L RNA-binding motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PRC-barrel domain	MgtE N-terminal domain-like	1	1
PIN domain-like	Ribonuclease H-like	1	1
UROD/MetE-like	UROD/MetE-like	1	1
MFS general substrate transporter	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	1	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1

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