Domain combination pairs in Caldicellulosiruptor owensensis OL

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

517 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	18	11
Actin-like ATPase domain	Actin-like ATPase domain	12	3
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	12	3
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	11	2
Homeodomain-like	Homeodomain-like	11	5
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	10	3
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like I	9	1
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	9	7
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	9	4
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	8	5
(Trans)glycosidases	Glycosyl hydrolase domain	8	4
HAMP domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	8	4
Galactose-binding domain-like	(Trans)glycosidases	8	7
CheY-like	C-terminal effector domain of the bipartite response regulators	7	1
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	7	2
Ribosomal protein S5 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	6	5
"Winged helix" DNA-binding domain	NagB/RpiA/CoA transferase-like	6	1
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	6	2
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	6	4
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	6	6
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	5	3
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	5	3
CheY-like	Homeodomain-like	5	2
Nucleotide cyclase	EAL domain-like	5	3
GroES-like	NAD(P)-binding Rossmann-fold domains	5	2
Galactose-binding domain-like	Galactose-binding domain-like	4	3
Histidine-containing phosphotransfer domain, HPT domain	CheW-like	4	4
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	4	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheW-like	4	4
PurM N-terminal domain-like	PurM C-terminal domain-like	4	2
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	4	2
Homodimeric domain of signal transducing histidine kinase	CheW-like	4	4
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	3
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	4	3
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	4	1
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	4	2
Translation proteins	EF-G C-terminal domain-like	4	2
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	4	2
Calcium ATPase, transduction domain A	HAD-like	4	3
HAD-like	Calcium ATPase, transmembrane domain M	4	3
CheY-like	Methylesterase CheB, C-terminal domain	4	1
ACT-like	ACT-like	4	2
EF-G C-terminal domain-like	EF-G C-terminal domain-like	4	2
Trypsin-like serine proteases	PDZ domain-like	3	2
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	3
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	3	2
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	3	2
beta-lactamase/transpeptidase-like	Penicillin-binding protein associated domain	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	3	2
Chemotaxis receptor methyltransferase CheR, N-terminal domain	S-adenosyl-L-methionine-dependent methyltransferases	3	1
Galactose mutarotase-like	Six-hairpin glycosidases	3	1
Histidine-containing phosphotransfer domain, HPT domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	3	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	3	3
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	1
Sensory domain-like	Methyl-accepting chemotaxis protein (MCP) signaling domain	3	3
Galactose mutarotase-like	(Trans)glycosidases	3	3
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	3	3
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	3	1
Regulatory protein AraC	Homeodomain-like	3	1
GAF domain-like	"Winged helix" DNA-binding domain	3	2
E set domains	(Trans)glycosidases	3	3
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	3	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	3	3
Nucleic acid-binding proteins	Nucleic acid-binding proteins	3	3
Alpha-L RNA-binding motif	Pseudouridine synthase	3	1
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	3	3
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	3	3
Ribosomal protein S5 domain 2-like	EF-G C-terminal domain-like	3	2
Histidine-containing phosphotransfer domain, HPT domain	Homodimeric domain of signal transducing histidine kinase	3	3
Zinc beta-ribbon	DNA primase core	3	3
GAF domain-like	Nucleotide cyclase	3	2
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	3
MalF N-terminal region-like	MetI-like	3	1
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	3	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	2	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	2	2
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	2	1
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
Penicillin-binding protein 2x (pbp-2x), c-terminal domain	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	2	2
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	2	1
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	2	1
Nucleotide-diphospho-sugar transferases	Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain	2	1
PYP-like sensor domain (PAS domain)	EAL domain-like	2	2
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
FKBP-like	Triger factor/SurA peptide-binding domain-like	2	2
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	2	1
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	2	2
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	2	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
CheY-binding domain of CheA	Homodimeric domain of signal transducing histidine kinase	2	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	2
PDZ domain-like	ClpP/crotonase	2	2
"Winged helix" DNA-binding domain	GntR ligand-binding domain-like	2	1
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	2	2
Galactose-binding domain-like	SGNH hydrolase	2	2
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	2	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	1
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	2	2
PreATP-grasp domain	PreATP-grasp domain	2	1
CheY-binding domain of CheA	CheW-like	2	2
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	2	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	2	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	2	1
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	2	2
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	2	1
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	2	2
Penicillin binding protein dimerisation domain	beta-lactamase/transpeptidase-like	2	2
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	2	1
HMA, heavy metal-associated domain	HAD-like	2	2
tRNA-binding arm	Class II aaRS and biotin synthetases	2	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
Aldolase	post-HMGL domain-like	2	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
MurCD N-terminal domain	MurD-like peptide ligases, peptide-binding domain	2	1
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	2	2
Fibronectin type III	Fibronectin type III	2	2
Translation proteins	Ribosomal protein S5 domain 2-like	2	1
Nucleic acid-binding proteins	Translation proteins SH3-like domain	2	2
FAD/NAD(P)-binding domain	Rhodanese/Cell cycle control phosphatase	2	2
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	2	1
CheY-binding domain of CheA	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	2	2
PreATP-grasp domain	Rudiment single hybrid motif	2	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	2	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	1
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	Rhodanese/Cell cycle control phosphatase	2	2
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	2	1
Concanavalin A-like lectins/glucanases	Galactose-binding domain-like	2	2
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	2	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	1
MurCD N-terminal domain	MurD-like peptide ligases, catalytic domain	2	1
Starch-binding domain-like	Starch-binding domain-like	2	2
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	2	2
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	2	2
4Fe-4S ferredoxins	FMN-linked oxidoreductases	2	2
PreATP-grasp domain	Methylglyoxal synthase-like	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	2	2
Histidine-containing phosphotransfer domain, HPT domain	CheY-binding domain of CheA	2	2
CheC-like	Surface presentation of antigens (SPOA)	2	2
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	2	1
4Fe-4S ferredoxins	Fe-only hydrogenase	2	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	1
Galactose mutarotase-like	Glycosyl hydrolase domain	2	2
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	2	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	2	1
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	2	2
L30e-like	alpha/beta knot	2	1
ParB/Sulfiredoxin	KorB DNA-binding domain-like	2	1
NAD(P)-linked oxidoreductase	4Fe-4S ferredoxins	2	1
TPR-like	TPR-like	2	2
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
YrdC/RibB	Actin-like ATPase domain	1	1
Thioredoxin-like	Nqo1C-terminal domain-like	1	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	1	1
Single hybrid motif	CoA-dependent acyltransferases	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
YrdC/RibB	RibA-like	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
ThrRS/AlaRS common domain	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	MOP-like	1	1
Periplasmic binding protein-like II	ACT-like	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
Nucleotidyltransferase	TGS-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
LigB-like	AMMECR1-like	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
Copper amine oxidase, domain N	LysM domain	1	1
Cytidine deaminase-like	Dihydrofolate reductase-like	1	1
Adenine nucleotide alpha hydrolases-like	MesJ substrate recognition domain-like	1	1
CarD-like	TRCF domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
PIN domain-like	Ribonuclease H-like	1	1
Starch-binding domain-like	E set domains	1	1
Periplasmic binding protein-like II	EAL domain-like	1	1
(Trans)glycosidases	CBD9-like	1	1
Metallo-hydrolase/oxidoreductase	Flavoproteins	1	1
cAMP-binding domain-like	"Winged helix" DNA-binding domain	1	1
FAD-binding/transporter-associated domain-like	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	1	1
TGS-like	ACT-like	1	1
Multidrug efflux transporter AcrB transmembrane domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Nqo1 middle domain-like	RuvA domain 2-like	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
Adenine nucleotide alpha hydrolases-like	PheT/TilS domain	1	1
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	1	1
Translation proteins	Translation proteins	1	1
LysM domain	LysM domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	1	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
ClpP/crotonase	ClpP/crotonase	1	1
E set domains	Glycosyl hydrolase domain	1	1
CBD9-like	CBD9-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	1	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
GIY-YIG endonuclease	RuvA domain 2-like	1	1
PheT/TilS domain	Anticodon-binding domain of PheRS	1	1
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	TPR-like	1	1
"Winged helix" DNA-binding domain	PLP-dependent transferases	1	1
DnaD domain-like	DnaD domain-like	1	1
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	1	1
RuvA domain 2-like	P-loop containing nucleoside triphosphate hydrolases	1	1
NAD(P)-linked oxidoreductase	alpha-helical ferredoxin	1	1
ClpP/crotonase	PGBD-like	1	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	1	1
"Winged helix" DNA-binding domain	Actin-like ATPase domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	1	1
lambda integrase-like, N-terminal domain	DNA breaking-rejoining enzymes	1	1
PDZ domain-like	Radical SAM enzymes	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
YhbC-like, N-terminal domain	YhbC-like, C-terminal domain	1	1
Ligand-binding domain in the NO signalling and Golgi transport	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
Nucleotidylyl transferase	tRNA-binding arm	1	1
RuvA domain 2-like	DNA helicase RuvA subunit, C-terminal domain	1	1
Radical SAM enzymes	RuvA domain 2-like	1	1
RuvA domain 2-like	BRCT domain	1	1
Nucleic acid-binding proteins	Putative DNA-binding domain	1	1
Periplasmic binding protein-like II	PYP-like sensor domain (PAS domain)	1	1
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	1	1
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
DNA repair protein MutS, domain III	SMR domain-like	1	1
Cell division protein ZapA-like	Tropomyosin	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	1	1
N-terminal domain of DnaB helicase	P-loop containing nucleoside triphosphate hydrolases	1	1
Lysozyme-like	beta-lactamase/transpeptidase-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Nucleic acid-binding proteins	1	1
Copper amine oxidase, domain N	Zn-dependent exopeptidases	1	1
beta and beta-prime subunits of DNA dependent RNA-polymerase	Duplicated hybrid motif	1	1
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
Pectin lyase-like	Pectin lyase-like	1	1
Enolase N-terminal domain-like	Enolase C-terminal domain-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
GroEL equatorial domain-like	GroEL apical domain-like	1	1
Cobalamin (vitamin B12)-binding domain	Radical SAM enzymes	1	1
Phosphoglycerate kinase	Triosephosphate isomerase (TIM)	1	1
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	1	1
HprK N-terminal domain-like	PEP carboxykinase-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Trigger factor ribosome-binding domain	FKBP-like	1	1
PUA domain-like	Ribosomal protein S5 domain 2-like	1	1
TGS-like	Class II aaRS ABD-related	1	1
CheW-like	CheW-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Aspartate/glutamate racemase	Aspartate/glutamate racemase	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
Formyltransferase	FMT C-terminal domain-like	1	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	1	1
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	TrpR-like	1	1
Translation proteins	Initiation factor IF2/eIF5b, domain 3	1	1
HisI-like	all-alpha NTP pyrophosphatases	1	1
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
DNA methylase specificity domain	DNA methylase specificity domain	1	1
HD-domain/PDEase-like	HD-domain/PDEase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
Galactose mutarotase-like	Putative glucosidase YicI, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	CarD-like	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, C-terminal domains	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
YbaK/ProRS associated domain	Class II aaRS ABD-related	1	1
AbrB/MazE/MraZ-like	GAF domain-like	1	1
PDZ domain-like	PGBD-like	1	1
MgtE N-terminal domain-like	CBS-domain pair	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
RmlC-like cupins	Homeodomain-like	1	1
UROD/MetE-like	UROD/MetE-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	1	1
Nucleotide-diphospho-sugar transferases	Phosphoglucomutase, first 3 domains	1	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	1	1
5' to 3' exonuclease, C-terminal subdomain	Ribonuclease H-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	1	1
Arabinanase/levansucrase/invertase	Galactose-binding domain-like	1	1
Nucleotide cyclase	TPR-like	1	1
Chaperone J-domain	TPR-like	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Eukaryotic type KH-domain (KH-domain type I)	HD-domain/PDEase-like	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	1	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
(Trans)glycosidases	Putative glucosidase YicI, C-terminal domain	1	1
Class II aaRS and biotin synthetases	YbaK/ProRS associated domain	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
Glycosyl hydrolase domain	Putative glucosidase YicI, C-terminal domain	1	1
HAMP domain-like	PYP-like sensor domain (PAS domain)	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
HlyD-like secretion proteins	HlyD-like secretion proteins	1	1
Molybdenum cofactor biosynthesis protein C, MoaC	PK beta-barrel domain-like	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphoenolpyruvate/pyruvate domain	1	1
Invasin/intimin cell-adhesion fragments	Cysteine proteinases	1	1
Nucleic acid-binding proteins	Anticodon-binding domain of PheRS	1	1
Thioredoxin-like	4Fe-4S ferredoxins	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphohistidine domain	1	1
2Fe-2S ferredoxin-like	Actin-like ATPase domain	1	1
Homocysteine S-methyltransferase	FAD-linked oxidoreductase	1	1
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	1	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type I DNA topoisomerase	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	4Fe-4S ferredoxins	1	1
Glutathione synthetase ATP-binding domain-like	MurD-like peptide ligases, catalytic domain	1	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	1	1
Nucleic acid-binding proteins	Prokaryotic type KH domain (KH-domain type II)	1	1
DnaK suppressor protein DksA, alpha-hairpin domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
MesJ substrate recognition domain-like	PheT/TilS domain	1	1
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
Nucleotide-diphospho-sugar transferases	TPR-like	1	1
Nucleotidyltransferase	ACT-like	1	1
GIY-YIG endonuclease	C-terminal UvrC-binding domain of UvrB	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	1	1
PIN domain-like	DNA/RNA polymerases	1	1
Zinc beta-ribbon	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	PheT/TilS domain	1	1
RNase III domain-like	dsRNA-binding domain-like	1	1
LysM domain	Duplicated hybrid motif	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
"Winged helix" DNA-binding domain	C-terminal domain of arginine repressor	1	1
DNA clamp	DNA clamp	1	1
Nucleotide cyclase	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
PK C-terminal domain-like	Phosphohistidine domain	1	1
Acylphosphatase/BLUF domain-like	YrdC/RibB	1	1
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
Arabinanase/levansucrase/invertase	Arabinanase/levansucrase/invertase	1	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
HD-domain/PDEase-like	TGS-like	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
PheT/TilS domain	Putative DNA-binding domain	1	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	1	1
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
GreA transcript cleavage protein, N-terminal domain	FKBP-like	1	1
Nucleic acid-binding proteins	RuvA domain 2-like	1	1
"Winged helix" DNA-binding domain	Periplasmic binding protein-like I	1	1
Homeodomain-like	SIS domain	1	1
Ribonuclease H-like	AF1531-like	1	1
Starch-binding domain-like	(Trans)glycosidases	1	1
GroEL equatorial domain-like	GroEL-intermediate domain like	1	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	1	1
"Winged helix" DNA-binding domain	LexA/Signal peptidase	1	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
Nucleotidylyl transferase	Riboflavin kinase-like	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	1	1
Transcription factor NusA, N-terminal domain	Prokaryotic type KH domain (KH-domain type II)	1	1
HIT-like	HIT-like	1	1
Translation proteins	PRC-barrel domain	1	1
L,D-transpeptidase catalytic domain-like	PGBD-like	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	1	1
Six-hairpin glycosidases	Six-hairpin glycosidases	1	1
Galactose-binding domain-like	Galactose mutarotase-like	1	1
alpha-helical ferredoxin	Nucleotide-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1
Thiamin diphosphate-binding fold (THDP-binding)	4Fe-4S ferredoxins	1	1
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
Molybdenum cofactor biosynthesis proteins	CinA-like	1	1
Dihydropteroate synthetase-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
EspE N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
"Winged helix" DNA-binding domain	PRTase-like	1	1
Periplasmic binding protein-like II	Nucleotide cyclase	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
Alpha-L RNA-binding motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	1	1
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	1	1
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
Nucleic acid-binding proteins	ArfGap/RecO-like zinc finger	1	1
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	P-loop containing nucleoside triphosphate hydrolases	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	1	1
Thioredoxin-like	Nqo1 FMN-binding domain-like	1	1
Putative DNA-binding domain	Anticodon-binding domain of PheRS	1	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	1	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	1	1
Sigma2 domain of RNA polymerase sigma factors	C-terminal effector domain of the bipartite response regulators	1	1
Nqo1C-terminal domain-like	4Fe-4S ferredoxins	1	1
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	PP2C-like	1	1
Ricin B-like lectins	alpha/beta-Hydrolases	1	1
PYP-like sensor domain (PAS domain)	PP2C-like	1	1
beta-Galactosidase/glucuronidase domain	Galactose mutarotase-like	1	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Acylphosphatase/BLUF domain-like	Actin-like ATPase domain	1	1
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	1	1
Serine metabolism enzymes domain	ACT-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	1	1
(Trans)glycosidases	Class I glutamine amidotransferase-like	1	1
Trimeric LpxA-like enzymes	Phosphoglucomutase, first 3 domains	1	1
PUA domain-like	alpha/beta knot	1	1
Thioredoxin-like	Nqo1 middle domain-like	1	1
TPR-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
Galactose-binding domain-like	CBD9-like	1	1
FliG	FliG	1	1
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	1	1
Hsp33 domain	HSP33 redox switch-like	1	1
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	1	1
NHL repeat	TPR-like	1	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
Carbamate kinase-like	ACT-like	1	1
Transcription factor NusA, N-terminal domain	Nucleic acid-binding proteins	1	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	1	1
lambda repressor-like DNA-binding domains	LexA/Signal peptidase	1	1
Nqo1 FMN-binding domain-like	4Fe-4S ferredoxins	1	1
Ferritin-like	Rubredoxin-like	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	1	1
all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	1	1
beta-lactamase/transpeptidase-like	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
5' to 3' exonuclease, C-terminal subdomain	DNA/RNA polymerases	1	1
GAF domain-like	HD-domain/PDEase-like	1	1
AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	1	1
Protein kinase-like (PK-like)	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	1	1
GroEL-intermediate domain like	GroEL apical domain-like	1	1
Penicillin binding protein dimerisation domain	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Nucleotide-binding domain	Nucleotide-binding domain	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Rubredoxin-like	Superoxide reductase-like	1	1
Nqo1 middle domain-like	4Fe-4S ferredoxins	1	1
HD-domain/PDEase-like	ACT-like	1	1
Periplasmic binding protein-like II	Galactose-binding domain-like	1	1
HD-domain/PDEase-like	Nucleotidyltransferase	1	1
Ribonuclease H-like	DNA/RNA polymerases	1	1
Thiolase-like	Thiolase-like	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	1	1
DeoB insert domain-like	Alkaline phosphatase-like	1	1
2Fe-2S ferredoxin-like	Fe-only hydrogenase	1	1
PK beta-barrel domain-like	Phosphohistidine domain	1	1
THUMP domain-like	Adenine nucleotide alpha hydrolases-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
NHL repeat	Cysteine proteinases	1	1
"Winged helix" DNA-binding domain	Chorismate lyase-like	1	1

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