All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 36 | 5 |  |
Carboxypeptidase regulatory domain-like | Porins | 31 | 6 |  |
Sigma2 domain of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 23 | 2 |  |
P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 18 | 10 |  |
TPR-like | TPR-like | 15 | 11 |  |
Homodimeric domain of signal transducing histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 14 | 11 |  |
Composite domain of metallo-dependent hydrolases | Metallo-dependent hydrolases | 13 | 6 |  |
Homeodomain-like | Homeodomain-like | 11 | 3 |  |
NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 11 | 5 |  |
Adenine nucleotide alpha hydrolases-like | Adenine nucleotide alpha hydrolases-like | 10 | 1 |  |
Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 9 | 1 |  |
Actin-like ATPase domain | Actin-like ATPase domain | 9 | 3 |  |
P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 9 | 5 |  |
Soluble quinoprotein glucose dehydrogenase | Cytochrome c | 8 | 6 |  |
RmlC-like cupins | Homeodomain-like | 8 | 1 |  |
Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 8 | 6 |  |
PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 8 | 5 |  |
Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 7 | 2 |  |
Thiamin diphosphate-binding fold (THDP-binding) | TK C-terminal domain-like | 7 | 5 |  |
TPR-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 7 | 5 |  |
Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 6 | 6 |  |
Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 6 | 2 |  |
MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, peptide-binding domain | 6 | 3 |  |
Galactose-binding domain-like | (Trans)glycosidases | 6 | 3 |  |
lambda repressor-like DNA-binding domains | Periplasmic binding protein-like I | 6 | 1 |  |
Acyl-CoA dehydrogenase NM domain-like | Acyl-CoA dehydrogenase C-terminal domain-like | 6 | 2 |  |
Multidrug efflux transporter AcrB transmembrane domain | Multidrug efflux transporter AcrB transmembrane domain | 6 | 5 |  |
Oligoxyloglucan reducing end-specific cellobiohydrolase | Sialidases | 5 | 5 |  |
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | Multidrug efflux transporter AcrB transmembrane domain | 5 | 4 |  |
(Trans)glycosidases | Galactose mutarotase-like | 5 | 3 |  |
GroES-like | NAD(P)-binding Rossmann-fold domains | 5 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 5 | 3 |  |
Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 5 | 2 |  |
Homodimeric domain of signal transducing histidine kinase | CheY-like | 5 | 5 |  |
Rhodanese/Cell cycle control phosphatase | Rhodanese/Cell cycle control phosphatase | 5 | 3 |  |
Integrin alpha N-terminal domain | Integrin alpha N-terminal domain | 5 | 2 |  |
Translation proteins | EF-G C-terminal domain-like | 5 | 3 |  |
cAMP-binding domain-like | "Winged helix" DNA-binding domain | 5 | 2 |  |
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | 5 | 4 |  |
"Winged helix" DNA-binding domain | Dimeric alpha+beta barrel | 5 | 1 |  |
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | Multidrug efflux transporter AcrB transmembrane domain | 5 | 4 |  |
P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 5 | 4 |  |
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | 5 | 4 |  |
PDZ domain-like | ClpP/crotonase | 5 | 3 |  |
FAD/NAD(P)-binding domain | FAD-linked reductases, C-terminal domain | 5 | 3 |  |
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | 5 | 4 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | CheY-like | 5 | 5 |  |
Galactose-binding domain-like | Galactose mutarotase-like | 4 | 2 |  |
beta-Galactosidase/glucuronidase domain | (Trans)glycosidases | 4 | 2 |  |
ClpP/crotonase | ClpP/crotonase | 4 | 2 |  |
beta-Galactosidase/glucuronidase domain | beta-Galactosidase/glucuronidase domain | 4 | 2 |  |
Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 4 | 2 |  |
Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 4 | 3 |  |
Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 4 | 3 |  |
Homeodomain-like | Tetracyclin repressor-like, C-terminal domain | 4 | 1 |  |
Enolase N-terminal domain-like | Enolase C-terminal domain-like | 4 | 1 |  |
NTF2-like | NTF2-like | 4 | 3 |  |
Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 4 | 4 |  |
Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 4 | 1 |  |
ABC transporter transmembrane region | P-loop containing nucleoside triphosphate hydrolases | 4 | 2 |  |
EF-G C-terminal domain-like | EF-G C-terminal domain-like | 4 | 2 |  |
CheY-like | C-terminal effector domain of the bipartite response regulators | 4 | 1 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 4 | 3 |  |
beta-Galactosidase/glucuronidase domain | Galactose mutarotase-like | 4 | 2 |  |
Galactose-binding domain-like | beta-Galactosidase/glucuronidase domain | 4 | 2 |  |
PreATP-grasp domain | Rudiment single hybrid motif | 4 | 2 |  |
PYP-like sensor domain (PAS domain) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 4 | 4 |  |
MurCD N-terminal domain | MurD-like peptide ligases, catalytic domain | 3 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 3 | 2 |  |
alpha/beta-Hydrolases | Galactose-binding domain-like | 3 | 3 |  |
ARM repeat | Cytochrome c | 3 | 2 |  |
Thiolase-like | Thiolase-like | 3 | 1 |  |
ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 3 | 3 |  |
Sialidases | Sialidases | 3 | 3 |  |
TPR-like | OmpA-like | 3 | 3 |  |
Alpha-L RNA-binding motif | Pseudouridine synthase | 3 | 1 |  |
Zn-dependent exopeptidases | Class I glutamine amidotransferase-like | 3 | 3 |  |
Galactose-binding domain-like | PKD domain | 3 | 3 |  |
DPP6 N-terminal domain-like | alpha/beta-Hydrolases | 3 | 2 |  |
Oligoxyloglucan reducing end-specific cellobiohydrolase | Oligoxyloglucan reducing end-specific cellobiohydrolase | 3 | 2 |  |
ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 3 | 3 |  |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | CoA-dependent acyltransferases | 3 | 2 |  |
LuxS/MPP-like metallohydrolase | LuxS/MPP-like metallohydrolase | 3 | 3 |  |
Single hybrid motif | CoA-dependent acyltransferases | 3 | 2 |  |
PurM N-terminal domain-like | PurM C-terminal domain-like | 3 | 2 |  |
beta-N-acetylhexosaminidase-like domain | (Trans)glycosidases | 3 | 2 |  |
Multiheme cytochromes | Multiheme cytochromes | 3 | 2 |  |
PKD domain | PKD domain | 3 | 3 |  |
Single hybrid motif | Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 3 | 2 |  |
Nucleic acid-binding proteins | RuvA domain 2-like | 3 | 3 |  |
Riboflavin synthase domain-like | Ferredoxin reductase-like, C-terminal NADP-linked domain | 3 | 3 |  |
MurCD N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 3 | 1 |  |
Leukotriene A4 hydrolase N-terminal domain | Metalloproteases ("zincins"), catalytic domain | 3 | 2 |  |
Composite domain of metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 3 | 2 |  |
FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | 3 | 2 |  |
Formate dehydrogenase/DMSO reductase, domains 1-3 | ADC-like | 3 | 1 |  |
Nucleic acid-binding proteins | Nucleic acid-binding proteins | 3 | 3 |  |
Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | 3 | 3 |  |
ACT-like | NAD(P)-binding Rossmann-fold domains | 3 | 3 |  |
P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 3 | 1 |  |
L30e-like | alpha/beta knot | 3 | 1 |  |
Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 3 | 1 |  |
Carbamate kinase-like | ACT-like | 3 | 3 |  |
(Trans)glycosidases | Glycosyl hydrolase domain | 3 | 3 |  |
LysM domain | LysM domain | 2 | 2 |  |
Cytochrome c | Cytochrome c | 2 | 2 |  |
NAD(P)-binding Rossmann-fold domains | TrkA C-terminal domain-like | 2 | 2 |  |
Galactose-binding domain-like | Kelch motif | 2 | 2 |  |
tRNA-binding arm | Class II aaRS and biotin synthetases | 2 | 1 |  |
Class II aaRS and biotin synthetases | ThrRS/AlaRS common domain | 2 | 2 |  |
TPR-like | DPP6 N-terminal domain-like | 2 | 2 |  |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 1 |  |
DNA/RNA polymerases | Lesion bypass DNA polymerase (Y-family), little finger domain | 2 | 2 |  |
Ribonuclease H-like | GIY-YIG endonuclease | 2 | 2 |  |
PYP-like sensor domain (PAS domain) | Homodimeric domain of signal transducing histidine kinase | 2 | 2 |  |
E set domains | Six-hairpin glycosidases | 2 | 1 |  |
2Fe-2S ferredoxin-like | CO dehydrogenase ISP C-domain like | 2 | 2 |  |
Cobalamin (vitamin B12)-dependent enzymes | Cobalamin (vitamin B12)-binding domain | 2 | 1 |  |
EF-G C-terminal domain-like | Ribosomal protein S5 domain 2-like | 2 | 1 |  |
PLP-binding barrel | Alanine racemase C-terminal domain-like | 2 | 1 |  |
Penicillin binding protein dimerisation domain | beta-lactamase/transpeptidase-like | 2 | 2 |  |
P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 2 | 2 |  |
Cadherin-like | PKD domain | 2 | 2 |  |
NagB/RpiA/CoA transferase-like | NagB/RpiA/CoA transferase-like | 2 | 1 |  |
Cytochrome c | Multiheme cytochromes | 2 | 2 |  |
TPR-like | Homodimeric domain of signal transducing histidine kinase | 2 | 2 |  |
Creatinase/prolidase N-terminal domain | Creatinase/aminopeptidase | 2 | 1 |  |
Triger factor/SurA peptide-binding domain-like | FKBP-like | 2 | 2 |  |
OMPA-like | OmpA-like | 2 | 2 |  |
DPP6 N-terminal domain-like | PDZ domain-like | 2 | 2 |  |
Double Clp-N motif | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 2 | 2 |  |
Lysozyme-like | beta-lactamase/transpeptidase-like | 2 | 2 |  |
6-phosphogluconate dehydrogenase C-terminal domain-like | 6-phosphogluconate dehydrogenase C-terminal domain-like | 2 | 2 |  |
Homeodomain-like | TPR-like | 2 | 1 |  |
PK beta-barrel domain-like | Phosphoenolpyruvate/pyruvate domain | 2 | 2 |  |
P-loop containing nucleoside triphosphate hydrolases | Homeodomain-like | 2 | 2 |  |
MurE/MurF N-terminal domain | MurD-like peptide ligases, catalytic domain | 2 | 1 |  |
NAD(P)-binding Rossmann-fold domains | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 2 | 1 |  |
Sigma3 and sigma4 domains of RNA polymerase sigma factors | Sigma3 and sigma4 domains of RNA polymerase sigma factors | 2 | 1 |  |
MurE/MurF N-terminal domain | MurD-like peptide ligases, peptide-binding domain | 2 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | PRTase-like | 2 | 2 |  |
Tricorn protease N-terminal domain | DPP6 N-terminal domain-like | 2 | 2 |  |
NAD(P)-binding Rossmann-fold domains | LDH C-terminal domain-like | 2 | 1 |  |
Metallo-hydrolase/oxidoreductase | Rhodanese/Cell cycle control phosphatase | 2 | 1 |  |
ACT-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 2 | 2 |  |
DPP6 N-terminal domain-like | OmpA-like | 2 | 2 |  |
Soluble quinoprotein glucose dehydrogenase | ARM repeat | 2 | 1 |  |
Translation proteins | Ribosomal protein S5 domain 2-like | 2 | 1 |  |
Carbamate kinase-like | NAD(P)-binding Rossmann-fold domains | 2 | 2 |  |
Calcium-dependent phosphotriesterase | Cytochrome c | 2 | 2 |  |
Calcium-dependent phosphotriesterase | ARM repeat | 2 | 2 |  |
Kelch motif | PKD domain | 2 | 2 |  |
alpha/beta-Hydrolases | TPR-like | 2 | 1 |  |
DNA repair protein MutS, domain III | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 1 |  |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 2 | 1 |  |
TK C-terminal domain-like | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 2 | 2 |  |
Peptidase/esterase 'gauge' domain | alpha/beta-Hydrolases | 2 | 1 |  |
Ferredoxin reductase-like, C-terminal NADP-linked domain | 2Fe-2S ferredoxin-like | 2 | 2 |  |
Molybdenum cofactor-binding domain | CO dehydrogenase molybdoprotein N-domain-like | 2 | 2 |  |
Concanavalin A-like lectins/glucanases | DNase I-like | 2 | 2 |  |
PEP carboxykinase N-terminal domain | PEP carboxykinase-like | 2 | 1 |  |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Sm-like ribonucleoproteins | 2 | 1 |  |
6-phosphogluconate dehydrogenase C-terminal domain-like | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 2 | 1 |  |
PYP-like sensor domain (PAS domain) | PYP-like sensor domain (PAS domain) | 2 | 2 |  |
CBS-domain pair | FAD-binding/transporter-associated domain-like | 2 | 1 |  |
Ribosomal protein S5 domain 2-like | Type II DNA topoisomerase | 2 | 1 |  |
Class I glutamine amidotransferase-like | PKD domain | 2 | 2 |  |
HSP40/DnaJ peptide-binding domain | HSP40/DnaJ peptide-binding domain | 2 | 2 |  |
Thiamin diphosphate-binding fold (THDP-binding) | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 2 | 2 |  |
CheY-like | Homeodomain-like | 2 | 2 |  |
Carbamate kinase-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 2 | 2 |  |
Glucocorticoid receptor-like (DNA-binding domain) | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
Tricorn protease N-terminal domain | ClpP/crotonase | 2 | 2 |  |
Cyclophilin-like | FKBP-like | 2 | 1 |  |
Aspartate/glutamate racemase | Aspartate/glutamate racemase | 2 | 1 |  |
CheY-like | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 |  |
PA domain | Zn-dependent exopeptidases | 2 | 1 |  |
Translation proteins SH3-like domain | Nucleic acid-binding proteins | 2 | 2 |  |
Galactose mutarotase-like | Six-hairpin glycosidases | 2 | 1 |  |
Tricorn protease N-terminal domain | PDZ domain-like | 2 | 2 |  |
DPP6 N-terminal domain-like | ClpP/crotonase | 2 | 2 |  |
TPR-like | Carboxypeptidase regulatory domain-like | 2 | 2 |  |
Chaperone J-domain | HSP40/DnaJ peptide-binding domain | 2 | 2 |  |
"Winged helix" DNA-binding domain | Periplasmic binding protein-like II | 2 | 1 |  |
Riboflavin synthase domain-like | 2Fe-2S ferredoxin-like | 2 | 2 |  |
RuvA domain 2-like | RuvA domain 2-like | 2 | 2 |  |
Sm-like ribonucleoproteins | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 2 | 1 |  |
ACT-like | ACT-like | 2 | 2 |  |
Galactose-binding domain-like | Galactose-binding domain-like | 2 | 1 |  |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 2 | 1 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Type II DNA topoisomerase | 2 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | HprK N-terminal domain-like | 1 | 1 |  |
Prokaryotic SH3-related domain | Cysteine proteinases | 1 | 1 |  |
Trigger factor ribosome-binding domain | Triger factor/SurA peptide-binding domain-like | 1 | 1 |  |
Glutathione synthetase ATP-binding domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
Class II aaRS and biotin synthetases | Anticodon-binding domain of PheRS | 1 | 1 |  |
Tropomyosin | OmpA-like | 1 | 1 |  |
Class II aaRS and biotin synthetases | GAD domain-like | 1 | 1 |  |
Translation proteins | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 |  |
4Fe-4S ferredoxins | 4Fe-4S ferredoxins | 1 | 1 |  |
Sensory domain-like | CheY-like | 1 | 1 |  |
TSP type-3 repeat | TSP type-3 repeat | 1 | 1 |  |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 |  |
NAD(P)-binding Rossmann-fold domains | Glutamyl tRNA-reductase dimerization domain | 1 | 1 |  |
PurM C-terminal domain-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
Prokaryotic type KH domain (KH-domain type II) | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 |  |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 1 | 1 |  |
DNA repair protein MutS, domain II | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
Alkaline phosphatase-like | Arabinanase/levansucrase/invertase | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 |  |
Nucleotidylyl transferase | Riboflavin kinase-like | 1 | 1 |  |
Formate dehydrogenase/DMSO reductase, domains 1-3 | 4Fe-4S ferredoxins | 1 | 1 |  |
Alkaline phosphatase-like | TPR-like | 1 | 1 |  |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 1 | 1 |  |
3-carboxy-cis,cis-mucoante lactonizing enzyme | PDZ domain-like | 1 | 1 |  |
Methylated DNA-protein cysteine methyltransferase domain | Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 1 | 1 |  |
beta-lactamase/transpeptidase-like | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 |  |
Zinc beta-ribbon | TPR-like | 1 | 1 |  |
MFS general substrate transporter | MFS general substrate transporter | 1 | 1 |  |
TPR-like | CheY-like | 1 | 1 |  |
Adenine nucleotide alpha hydrolases-like | DHS-like NAD/FAD-binding domain | 1 | 1 |  |
Periplasmic binding protein-like II | HemD-like | 1 | 1 |  |
PheT/TilS domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | TrpR-like | 1 | 1 |  |
CalX-like | Cna protein B-type domain | 1 | 1 |  |
NAD(P)-binding Rossmann-fold domains | Isocitrate/Isopropylmalate dehydrogenase-like | 1 | 1 |  |
CalX-like | CalX-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 1 | 1 |  |
HAD-like | ACT-like | 1 | 1 |  |
MoeA N-terminal region -like | MoeA C-terminal domain-like | 1 | 1 |  |
Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
DPP6 N-terminal domain-like | Composite domain of metallo-dependent hydrolases | 1 | 1 |  |
Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 |  |
GreA transcript cleavage protein, N-terminal domain | FKBP-like | 1 | 1 |  |
OMPA-like | TSP type-3 repeat | 1 | 1 |  |
S-adenosyl-L-methionine-dependent methyltransferases | DNA methylase specificity domain | 1 | 1 |  |
Class I glutamine amidotransferase-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
UBA-like | Elongation factor Ts (EF-Ts), dimerisation domain | 1 | 1 |  |
Lysozyme-like | LysM domain | 1 | 1 |  |
ParB/Sulfiredoxin | KorB DNA-binding domain-like | 1 | 1 |  |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Adenine nucleotide alpha hydrolases-like | 1 | 1 |  |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | Nucleic acid-binding proteins | 1 | 1 |  |
TrkA C-terminal domain-like | TrkA C-terminal domain-like | 1 | 1 |  |
Type II DNA topoisomerase | GyrA/ParC C-terminal domain-like | 1 | 1 |  |
Soluble quinoprotein glucose dehydrogenase | PKD domain | 1 | 1 |  |
Sensory domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
Dihydropteroate synthetase-like | Methionine synthase domain | 1 | 1 |  |
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | HemD-like | 1 | 1 |  |
(Trans)glycosidases | Chitinase insertion domain | 1 | 1 |  |
Ribosomal protein L6 | Ribosomal protein L6 | 1 | 1 |  |
PLP-dependent transferases | PLP-dependent transferases | 1 | 1 |  |
all-alpha NTP pyrophosphatases | all-alpha NTP pyrophosphatases | 1 | 1 |  |
RNI-like | Galactose-binding domain-like | 1 | 1 |  |
Aldolase | AFP III-like domain | 1 | 1 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Homeodomain-like | 1 | 1 |  |
FGAM synthase PurL, linker domain | PurM N-terminal domain-like | 1 | 1 |  |
Translation initiation factor IF3, N-terminal domain | Translation initiation factor IF3, C-terminal domain | 1 | 1 |  |
NAD(P)-binding Rossmann-fold domains | Succinyl-CoA synthetase domains | 1 | 1 |  |
LexA/Signal peptidase | LexA/Signal peptidase | 1 | 1 |  |
PK beta-barrel domain-like | PK C-terminal domain-like | 1 | 1 |  |
OmpA-like | OmpA-like | 1 | 1 |  |
TGS-like | Class II aaRS ABD-related | 1 | 1 |  |
CalX-like | Pectin lyase-like | 1 | 1 |  |
GroEL-intermediate domain like | GroEL apical domain-like | 1 | 1 |  |
Nucleic acid-binding proteins | DNA helicase RuvA subunit, C-terminal domain | 1 | 1 |  |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
Translation proteins | ThrRS/AlaRS common domain | 1 | 1 |  |
5' to 3' exonuclease, C-terminal subdomain | Ribonuclease H-like | 1 | 1 |  |
Nucleotide-diphospho-sugar transferases | Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain | 1 | 1 |  |
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | Outer membrane efflux proteins (OEP) | 1 | 1 |  |
TPR-like | Porins | 1 | 1 |  |
NAD(P)-binding Rossmann-fold domains | ClpP/crotonase | 1 | 1 |  |
Phosphoenolpyruvate/pyruvate domain | PK C-terminal domain-like | 1 | 1 |  |
Nudix | "Winged helix" DNA-binding domain | 1 | 1 |  |
Kelch motif | Kelch motif | 1 | 1 |  |
Cadherin-like | Galactose-binding domain-like | 1 | 1 |  |
PurS-like | FGAM synthase PurL, linker domain | 1 | 1 |  |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Alpha subunit of glutamate synthase, C-terminal domain | 1 | 1 |  |
Voltage-gated potassium channels | TrkA C-terminal domain-like | 1 | 1 |  |
Diaminopimelate epimerase-like | Diaminopimelate epimerase-like | 1 | 1 |  |
alpha/beta-Hydrolases | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | 1 |  |
Duplicated hybrid motif | PLP-dependent transferases | 1 | 1 |  |
NAD(P)-binding Rossmann-fold domains | Siroheme synthase middle domains-like | 1 | 1 |  |
Cupredoxins | Cupredoxins | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | RecA protein, C-terminal domain | 1 | 1 |  |
Tex N-terminal region-like | RuvA domain 2-like | 1 | 1 |  |
HD-domain/PDEase-like | TGS-like | 1 | 1 |  |
FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | 1 |  |
PurS-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
Methionine synthase domain | Cobalamin (vitamin B12)-binding domain | 1 | 1 |  |
HAMP domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
Hypothetical protein TM0160 | C-terminal UvrC-binding domain of UvrB | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Restriction endonuclease-like | 1 | 1 |  |
FMN-linked oxidoreductases | Nucleotide-binding domain | 1 | 1 |  |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | FMN-linked oxidoreductases | 1 | 1 |  |
DNA-glycosylase | Nudix | 1 | 1 |  |
Formyltransferase | FMT C-terminal domain-like | 1 | 1 |  |
Nucleic acid-binding proteins | ArfGap/RecO-like zinc finger | 1 | 1 |  |
Methylglyoxal synthase-like | Cytidine deaminase-like | 1 | 1 |  |
Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
L9 N-domain-like | Ribosomal protein L9 C-domain | 1 | 1 |  |
Insert subdomain of RNA polymerase alpha subunit | C-terminal domain of RNA polymerase alpha subunit | 1 | 1 |  |
Ribonuclease PH domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 1 | 1 |  |
Nucleotidylyl transferase | Nucleic acid-binding proteins | 1 | 1 |  |
N-terminal domain of DnaB helicase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
PIN domain-like | DNA/RNA polymerases | 1 | 1 |  |
Integrin alpha N-terminal domain | Immunoglobulin | 1 | 1 |  |
6-phosphogluconate dehydrogenase C-terminal domain-like | ClpP/crotonase | 1 | 1 |  |
3-carboxy-cis,cis-mucoante lactonizing enzyme | ClpP/crotonase | 1 | 1 |  |
Cadherin-like | Kelch motif | 1 | 1 |  |
Voltage-gated potassium channels | Periplasmic binding protein-like II | 1 | 1 |  |
PheT/TilS domain | Putative DNA-binding domain | 1 | 1 |  |
Ribosomal protein L7/12, oligomerisation (N-terminal) domain | ClpS-like | 1 | 1 |  |
Nucleic acid-binding proteins | BRCT domain | 1 | 1 |  |
"Winged helix" DNA-binding domain | Periplasmic binding protein-like I | 1 | 1 |  |
Ribonuclease PH domain 2-like | Nucleic acid-binding proteins | 1 | 1 |  |
RuvA domain 2-like | DNA helicase RuvA subunit, C-terminal domain | 1 | 1 |  |
ARM repeat | Galactose-binding domain-like | 1 | 1 |  |
Hypothetical protein SAV1430 | Hypothetical protein SAV1430 | 1 | 1 |  |
Transcription factor NusA, N-terminal domain | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 |  |
Class II aaRS and biotin synthetases | Translation proteins | 1 | 1 |  |
NagB/RpiA/CoA transferase-like | LmbE-like | 1 | 1 |  |
cAMP-binding domain-like | CBS-domain pair | 1 | 1 |  |
Translation proteins | Translation proteins | 1 | 1 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | DNA mismatch repair protein MutL | 1 | 1 |  |
Soluble quinoprotein glucose dehydrogenase | Anthrax protective antigen | 1 | 1 |  |
Heme-dependent peroxidases | Heme-dependent peroxidases | 1 | 1 |  |
L9 N-domain-like | Ribonuclease H-like | 1 | 1 |  |
Pre-protein crosslinking domain of SecA | Helical scaffold and wing domains of SecA | 1 | 1 |  |
Adenine nucleotide alpha hydrolases-like | Argininosuccinate synthetase, C-terminal domain | 1 | 1 |  |
Class I glutamine amidotransferase-like | Cadherin-like | 1 | 1 |  |
FMN-linked oxidoreductases | Alpha subunit of glutamate synthase, C-terminal domain | 1 | 1 |  |
TSP type-3 repeat | OmpA-like | 1 | 1 |  |
Pectin lyase-like | PDZ domain-like | 1 | 1 |  |
Glutamyl tRNA-reductase catalytic, N-terminal domain | Glutamyl tRNA-reductase dimerization domain | 1 | 1 |  |
PKD domain | Cytochrome c | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | TPR-like | 1 | 1 |  |
Tex N-terminal region-like | Ribonuclease H-like | 1 | 1 |  |
Chaperone J-domain | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 |  |
Thiamin diphosphate-binding fold (THDP-binding) | 4Fe-4S ferredoxins | 1 | 1 |  |
ThrRS/AlaRS common domain | Class II aaRS ABD-related | 1 | 1 |  |
MgtE N-terminal domain-like | MgtE membrane domain-like | 1 | 1 |  |
FAD-linked oxidases, C-terminal domain | alpha-helical ferredoxin | 1 | 1 |  |
Cupredoxins | Cytochrome c | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | Nucleic acid-binding proteins | 1 | 1 |  |
Phospholipase D/nuclease | Phospholipase D/nuclease | 1 | 1 |  |
HD-domain/PDEase-like | ACT-like | 1 | 1 |  |
Formate/glycerate dehydrogenase catalytic domain-like | ACT-like | 1 | 1 |  |
FAD-binding/transporter-associated domain-like | alpha-helical ferredoxin | 1 | 1 |  |
E set domains | Glycosyl hydrolase domain | 1 | 1 |  |
Tricorn protease N-terminal domain | 3-carboxy-cis,cis-mucoante lactonizing enzyme | 1 | 1 |  |
CarD-like | TRCF domain-like | 1 | 1 |  |
Lamin A/C globular tail domain | PKD domain | 1 | 1 |  |
S-adenosyl-L-methionine-dependent methyltransferases | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 1 | 1 |  |
Glutathione synthetase ATP-binding domain-like | Succinyl-CoA synthetase domains | 1 | 1 |  |
DNA repair protein MutS, domain II | DNA repair protein MutS, domain III | 1 | 1 |  |
Nucleotidylyl transferase | tRNA-binding arm | 1 | 1 |  |
lambda repressor-like DNA-binding domains | LexA/Signal peptidase | 1 | 1 |  |
SGNH hydrolase | Calcium-dependent phosphotriesterase | 1 | 1 |  |
Nucleic acid-binding proteins | GAD domain-like | 1 | 1 |  |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 1 | 1 |  |
Multidrug efflux transporter AcrB transmembrane domain | Outer membrane efflux proteins (OEP) | 1 | 1 |  |
Pectin lyase-like | Cytochrome c | 1 | 1 |  |
alpha/beta-Hydrolases | OsmC-like | 1 | 1 |  |
LysM domain | Periplasmic binding protein-like I | 1 | 1 |  |
YrdC/RibB | RibA-like | 1 | 1 |  |
Immunoglobulin | TSP type-3 repeat | 1 | 1 |  |
Tricorn protease N-terminal domain | NTF2-like | 1 | 1 |  |
Calcium-dependent phosphotriesterase | Homeodomain-like | 1 | 1 |  |
PDZ domain-like | PDZ domain-like | 1 | 1 |  |
Regulatory protein AraC | Homeodomain-like | 1 | 1 |  |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleotidylyl transferase | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | HSP90 C-terminal domain | 1 | 1 |  |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | Alkaline phosphatase-like | 1 | 1 |  |
Zn-dependent exopeptidases | Fibronectin type III | 1 | 1 |  |
4'-phosphopantetheinyl transferase | 4'-phosphopantetheinyl transferase | 1 | 1 |  |
TPR-like | C-terminal effector domain of the bipartite response regulators | 1 | 1 |  |
Glycerol-3-phosphate (1)-acyltransferase | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
Nitrous oxide reductase, N-terminal domain | Cupredoxins | 1 | 1 |  |
Fumarylacetoacetate hydrolase, FAH, N-terminal domain | FAH | 1 | 1 |  |
DPP6 N-terminal domain-like | Metallo-dependent hydrolases | 1 | 1 |  |
PKD domain | TSP type-3 repeat | 1 | 1 |  |
MoeA N-terminal region -like | Molybdenum cofactor biosynthesis proteins | 1 | 1 |  |
Putative DNA-binding domain | Anticodon-binding domain of PheRS | 1 | 1 |  |
CBS-domain pair | MgtE membrane domain-like | 1 | 1 |  |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
Nucleotide-binding domain | FAD-linked reductases, C-terminal domain | 1 | 1 |  |
TGS-like | ACT-like | 1 | 1 |  |
Obg GTP-binding protein N-terminal domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
GAF domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | Quinoprotein alcohol dehydrogenase-like | 1 | 1 |  |
FMN-linked oxidoreductases | FAD/NAD(P)-binding domain | 1 | 1 |  |
CheY-like | cAMP-binding domain-like | 1 | 1 |  |
Calcium-dependent phosphotriesterase | Calcium-dependent phosphotriesterase | 1 | 1 |  |
Calcium-dependent phosphotriesterase | CheY-like | 1 | 1 |  |
Sensory domain-like | Homodimeric domain of signal transducing histidine kinase | 1 | 1 |  |
Ribonuclease PH domain 2-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
Class II aaRS and biotin synthetases | C-terminal domain of ProRS | 1 | 1 |  |
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | Outer membrane efflux proteins (OEP) | 1 | 1 |  |
Arabinanase/levansucrase/invertase | (Trans)glycosidases | 1 | 1 |  |
FAS1 domain | FAS1 domain | 1 | 1 |  |
Dihydropteroate synthetase-like | Cobalamin (vitamin B12)-binding domain | 1 | 1 |  |
Molybdenum cofactor biosynthesis proteins | CinA-like | 1 | 1 |  |
Metalloproteases ("zincins"), catalytic domain | Galactose-binding domain-like | 1 | 1 |  |
PurM N-terminal domain-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | C-terminal UvrC-binding domain of UvrB | 1 | 1 |  |
Ribonuclease PH domain 2-like | Ribonuclease PH domain 2-like | 1 | 1 |  |
"Winged helix" DNA-binding domain | HRDC-like | 1 | 1 |  |
Coiled-coil domain of nucleotide exchange factor GrpE | Head domain of nucleotide exchange factor GrpE | 1 | 1 |  |
Arabinanase/levansucrase/invertase | Concanavalin A-like lectins/glucanases | 1 | 1 |  |
DPP6 N-terminal domain-like | Cna protein B-type domain | 1 | 1 |  |
Calcium-dependent phosphotriesterase | C-terminal effector domain of the bipartite response regulators | 1 | 1 |  |
Cytochrome c oxidase subunit III-like | Cytochrome c oxidase subunit III-like | 1 | 1 |  |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 1 | 1 |  |
alpha/beta-Hydrolases | ACT-like | 1 | 1 |  |
Lamin A/C globular tail domain | Lamin A/C globular tail domain | 1 | 1 |  |
SGNH hydrolase | Cytochrome c | 1 | 1 |  |
FabD/lysophospholipase-like | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 1 | 1 |  |
Fe-S cluster assembly (FSCA) domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
R1 subunit of ribonucleotide reductase, N-terminal domain | PFL-like glycyl radical enzymes | 1 | 1 |  |
Class I glutamine amidotransferase-like | TSP type-3 repeat | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | CarD-like | 1 | 1 |  |
Calcium-dependent phosphotriesterase | Cupredoxins | 1 | 1 |  |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | Translation proteins | 1 | 1 |  |
Cryptochrome/photolyase, N-terminal domain | Cryptochrome/photolyase FAD-binding domain | 1 | 1 |  |
Galactose-binding domain-like | Six-hairpin glycosidases | 1 | 1 |  |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 1 | 1 |  |
Glutathione synthetase ATP-binding domain-like | Phosphohistidine domain | 1 | 1 |  |
CheY-like | Histidine-containing phosphotransfer domain, HPT domain | 1 | 1 |  |
Class II aaRS ABD-related | C-terminal domain of ProRS | 1 | 1 |  |
Nucleic acid-binding proteins | Putative DNA-binding domain | 1 | 1 |  |
HCP-like | TPR-like | 1 | 1 |  |
S-adenosyl-L-methionine-dependent methyltransferases | MCP/YpsA-like | 1 | 1 |  |
Voltage-gated potassium channels | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
Cadherin-like | TSP type-3 repeat | 1 | 1 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Histidine-containing phosphotransfer domain, HPT domain | 1 | 1 |  |
DPP6 N-terminal domain-like | 3-carboxy-cis,cis-mucoante lactonizing enzyme | 1 | 1 |  |
TGS-like | Class II aaRS and biotin synthetases | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
Metalloproteases ("zincins"), catalytic domain | PDZ domain-like | 1 | 1 |  |
Nucleotide-binding domain | Nucleotide-binding domain | 1 | 1 |  |
Cadherin-like | Cadherin-like | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | Ribonuclease PH domain 2-like | 1 | 1 |  |
NAD-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 1 | 1 |  |
Rho N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
SGNH hydrolase | SGNH hydrolase | 1 | 1 |  |
Nitrite/Sulfite reductase N-terminal domain-like | Nitrite/Sulfite reductase N-terminal domain-like | 1 | 1 |  |
Glutamine synthetase, N-terminal domain | Glutamine synthetase/guanido kinase | 1 | 1 |  |
HIT-like | HIT-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | TGS-like | 1 | 1 |  |
Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 |  |
Protein kinase-like (PK-like) | PLP-dependent transferases | 1 | 1 |  |
GAF domain-like | Homodimeric domain of signal transducing histidine kinase | 1 | 1 |  |
CheY-like | "Winged helix" DNA-binding domain | 1 | 1 |  |
Cytochrome c | Anthrax protective antigen | 1 | 1 |  |
TerB-like | Chaperone J-domain | 1 | 1 |  |
"Winged helix" DNA-binding domain | Chorismate lyase-like | 1 | 1 |  |
FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 1 | 1 |  |
Translation proteins | PRC-barrel domain | 1 | 1 |  |
HAMP domain-like | Homodimeric domain of signal transducing histidine kinase | 1 | 1 |  |
Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 1 | 1 |  |
TPR-like | Cna protein B-type domain | 1 | 1 |  |
CheY-like | Alkaline phosphatase-like | 1 | 1 |  |
FGAM synthase PurL, linker domain | PurM C-terminal domain-like | 1 | 1 |  |
NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
Aldolase | Chorismate mutase II | 1 | 1 |  |
Nucleotide cyclase | Homeodomain-like | 1 | 1 |  |
Clc chloride channel | CBS-domain pair | 1 | 1 |  |
Nucleic acid-binding proteins | PheT/TilS domain | 1 | 1 |  |
DNA clamp | DNA clamp | 1 | 1 |  |
Galactose-binding domain-like | Lamin A/C globular tail domain | 1 | 1 |  |
GIY-YIG endonuclease | C-terminal UvrC-binding domain of UvrB | 1 | 1 |  |
Dihydropteroate synthetase-like | Methionine synthase activation domain-like | 1 | 1 |  |
DNA repair protein MutS, domain I | DNA repair protein MutS, domain II | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | TRCF domain-like | 1 | 1 |  |
PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 |  |
Nucleic acid-binding proteins | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 |  |
Galactose-binding domain-like | Cupredoxins | 1 | 1 |  |
PreATP-grasp domain | PreATP-grasp domain | 1 | 1 |  |
ARM repeat | Cupredoxins | 1 | 1 |  |
Homodimeric domain of signal transducing histidine kinase | Homeodomain-like | 1 | 1 |  |
Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Isocitrate/Isopropylmalate dehydrogenase-like | 1 | 1 |  |
Ribosomal L11/L12e N-terminal domain | Ribosomal protein L11, C-terminal domain | 1 | 1 |  |
RuvA domain 2-like | BRCT domain | 1 | 1 |  |
"Winged helix" DNA-binding domain | Iron-dependent repressor protein, dimerization domain | 1 | 1 |  |
MCP/YpsA-like | Nudix | 1 | 1 |  |
dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
Galactose mutarotase-like | Galactose mutarotase-like | 1 | 1 |  |
Multiheme cytochromes | TPR-like | 1 | 1 |  |
GroEL equatorial domain-like | GroEL-intermediate domain like | 1 | 1 |  |
Arabinanase/levansucrase/invertase | Arabinanase/levansucrase/invertase | 1 | 1 |  |
IlvD/EDD N-terminal domain-like | LeuD/IlvD-like | 1 | 1 |  |
Nitrite and sulphite reductase 4Fe-4S domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 1 | 1 |  |
Cna protein B-type domain | Pectin lyase-like | 1 | 1 |  |
vWA-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
Cytochrome c oxidase subunit I-like | Cytochrome c | 1 | 1 |  |
LmbE-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
2Fe-2S ferredoxin-like | alpha-helical ferredoxin | 1 | 1 |  |
HD-domain/PDEase-like | Nucleotidyltransferase | 1 | 1 |  |
Adenine nucleotide alpha hydrolases-like | PheT/TilS domain | 1 | 1 |  |
Nucleic acid-binding proteins | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
TGS-like | ThrRS/AlaRS common domain | 1 | 1 |  |
alpha/beta-Hydrolases | Carbamate kinase-like | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 |  |
Thiamin diphosphate-binding fold (THDP-binding) | DHS-like NAD/FAD-binding domain | 1 | 1 |  |
Nucleotidyltransferase | Poly A polymerase C-terminal region-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Pre-protein crosslinking domain of SecA | 1 | 1 |  |
Ribonuclease H-like | DNA/RNA polymerases | 1 | 1 |  |
Nitrite/Sulfite reductase N-terminal domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 1 | 1 |  |
Class I glutamine amidotransferase-like | GMP synthetase C-terminal dimerisation domain | 1 | 1 |  |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleic acid-binding proteins | 1 | 1 |  |
Calcium-dependent phosphotriesterase | Class I glutamine amidotransferase-like | 1 | 1 |  |
4Fe-4S ferredoxins | FAD/NAD(P)-binding domain | 1 | 1 |  |
Ribonuclease H-like | Nucleic acid-binding proteins | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | CheY-like | 1 | 1 |  |
HMA, heavy metal-associated domain | Calcium ATPase, transduction domain A | 1 | 1 |  |
Aminoacid dehydrogenase-like, N-terminal domain | Isocitrate/Isopropylmalate dehydrogenase-like | 1 | 1 |  |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | HSP90 C-terminal domain | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | Thioesterase/thiol ester dehydrase-isomerase | 1 | 1 |  |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Nucleotidylyl transferase | 1 | 1 |  |
Nucleotidyltransferase | ACT-like | 1 | 1 |  |
Hypothetical protein SAV1430 | Fe-S cluster assembly (FSCA) domain-like | 1 | 1 |  |
Acyl-CoA N-acyltransferases (Nat) | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 |  |
CBS-domain pair | Inosine monophosphate dehydrogenase (IMPDH) | 1 | 1 |  |
5' to 3' exonuclease, C-terminal subdomain | DNA/RNA polymerases | 1 | 1 |  |
Oxidoreductase molybdopterin-binding domain | E set domains | 1 | 1 |  |
Methionine synthase domain | Methionine synthase activation domain-like | 1 | 1 |  |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 1 | 1 |  |
Single hybrid motif | Single hybrid motif | 1 | 1 |  |
N-utilization substance G protein NusG, N-terminal domain | Translation proteins SH3-like domain | 1 | 1 |  |
DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 1 | 1 |  |
PIN domain-like | Ribonuclease H-like | 1 | 1 |  |
S-adenosyl-L-methionine-dependent methyltransferases | Putative methyltransferase TM0872, insert domain | 1 | 1 |  |
YhbC-like, N-terminal domain | YhbC-like, C-terminal domain | 1 | 1 |  |
C-terminal UvrC-binding domain of UvrB | RuvA domain 2-like | 1 | 1 |  |
RNase III domain-like | dsRNA-binding domain-like | 1 | 1 |  |
Bacterial fluorinating enzyme, N-terminal domain | Bacterial fluorinating enzyme, C-terminal domain | 1 | 1 |  |
Aconitase iron-sulfur domain | LeuD/IlvD-like | 1 | 1 |  |
Nucleotidylyl transferase | Ribosomal protein L25-like | 1 | 1 |  |
YjeF N-terminal domain-like | Ribokinase-like | 1 | 1 |  |
ISP domain | Bet v1-like | 1 | 1 |  |
"Winged helix" DNA-binding domain | PLP-dependent transferases | 1 | 1 |  |
Cobalamin (vitamin B12)-binding domain | Methionine synthase activation domain-like | 1 | 1 |  |
Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 |  |
Acyl-CoA N-acyltransferases (Nat) | Xylose isomerase-like | 1 | 1 |  |
PurM N-terminal domain-like | PurM N-terminal domain-like | 1 | 1 |  |
Cytochrome c oxidase subunit II-like, transmembrane region | Cupredoxins | 1 | 1 |  |
Tex N-terminal region-like | Nucleic acid-binding proteins | 1 | 1 |  |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
(Trans)glycosidases | beta-lactamase/transpeptidase-like | 1 | 1 |  |
DNA ligase/mRNA capping enzyme, catalytic domain | RuvA domain 2-like | 1 | 1 |  |
Carboxypeptidase regulatory domain-like | OmpA-like | 1 | 1 |  |
(Trans)glycosidases | Beta-D-glucan exohydrolase, C-terminal domain | 1 | 1 |  |
Nucleotidylyl transferase | Alpha-L RNA-binding motif | 1 | 1 |  |
Calcium ATPase, transduction domain A | HAD-like | 1 | 1 |  |
HAD-like | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
Molybdenum cofactor-binding domain | Molybdenum cofactor-binding domain | 1 | 1 |  |
E set domains | (Trans)glycosidases | 1 | 1 |  |
Rho N-terminal domain-like | Nucleic acid-binding proteins | 1 | 1 |  |
Glutamyl tRNA-reductase catalytic, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
FAD-binding/transporter-associated domain-like | Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 1 | 1 |  |
"Winged helix" DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 1 | 1 |  |
Galactose-binding domain-like | Class I glutamine amidotransferase-like | 1 | 1 |  |
HisI-like | all-alpha NTP pyrophosphatases | 1 | 1 |  |
Calcium-dependent phosphotriesterase | Galactose-binding domain-like | 1 | 1 |  |
CheY-like | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
HAD-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
HprK N-terminal domain-like | Isocitrate/Isopropylmalate dehydrogenase-like | 1 | 1 |  |
HAD-like | Formate/glycerate dehydrogenase catalytic domain-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Class I glutamine amidotransferase-like | 1 | 1 |  |
UDP-Glycosyltransferase/glycogen phosphorylase | HAD-like | 1 | 1 |  |
Class I glutamine amidotransferase-like | Cytochrome c | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Helical scaffold and wing domains of SecA | 1 | 1 |  |
Molybdenum cofactor biosynthesis proteins | MoeA C-terminal domain-like | 1 | 1 |  |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | CoaB-like | 1 | 1 |  |
PUA domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 |  |
Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 1 | 1 |  |
Adenine nucleotide alpha hydrolases-like | GMP synthetase C-terminal dimerisation domain | 1 | 1 |  |
Periplasmic binding protein-like II | GlnB-like | 1 | 1 |  |
Kelch motif | Lamin A/C globular tail domain | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | Homodimeric domain of signal transducing histidine kinase | 1 | 1 |  |
GIY-YIG endonuclease | RuvA domain 2-like | 1 | 1 |  |
DNA repair protein MutS, domain I | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
Penicillin binding protein dimerisation domain | Penicillin-binding protein 2x (pbp-2x), c-terminal domain | 1 | 1 |  |
S-adenosylmethionine synthetase | S-adenosylmethionine synthetase | 1 | 1 |  |
alpha/beta-Hydrolases | NAD(P)-binding Rossmann-fold domains | 1 | 1 |  |
Nucleic acid-binding proteins | Anticodon-binding domain of PheRS | 1 | 1 |  |
"Winged helix" DNA-binding domain | GntR ligand-binding domain-like | 1 | 1 |  |
Periplasmic binding protein-like II | ACT-like | 1 | 1 |  |
SGNH hydrolase | ARM repeat | 1 | 1 |  |
Calcium-dependent phosphotriesterase | Homodimeric domain of signal transducing histidine kinase | 1 | 1 |  |
Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 1 | 1 |  |
Purple acid phosphatase, N-terminal domain | Metallo-dependent phosphatases | 1 | 1 |  |
FKBP-like | FKBP-like | 1 | 1 |  |
Respiratory nitrate reductase 1 gamma chain | alpha-helical ferredoxin | 1 | 1 |  |
ARM repeat | Class I glutamine amidotransferase-like | 1 | 1 |  |
Trypsin-like serine proteases | PDZ domain-like | 1 | 1 |  |
Transcription factor NusA, N-terminal domain | Nucleic acid-binding proteins | 1 | 1 |  |
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 4Fe-4S ferredoxins | 1 | 1 |  |
GroEL equatorial domain-like | GroEL apical domain-like | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | Calcium-dependent phosphotriesterase | 1 | 1 |  |
FAD-binding/transporter-associated domain-like | CO dehydrogenase flavoprotein C-terminal domain-like | 1 | 1 |  |
Folate-binding domain | Aminomethyltransferase beta-barrel domain | 1 | 1 |  |
ValRS/IleRS/LeuRS editing domain | tRNA-binding arm | 1 | 1 |  |
(Trans)glycosidases | (Trans)glycosidases | 1 | 1 |  |
FAD/NAD(P)-binding domain | HI0933 insert domain-like | 1 | 1 |  |
UDP-Glycosyltransferase/glycogen phosphorylase | Nucleotide-diphospho-sugar transferases | 1 | 1 |  |
Thioredoxin-like | Six-hairpin glycosidases | 1 | 1 |  |
FGAM synthase PurL, linker domain | Class I glutamine amidotransferase-like | 1 | 1 |  |
PUA domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 |  |
PheT/TilS domain | Anticodon-binding domain of PheRS | 1 | 1 |  |
RBP11-like subunits of RNA polymerase | C-terminal domain of RNA polymerase alpha subunit | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | Homeodomain-like | 1 | 1 |  |
alpha/beta-Hydrolases | beta-lactamase/transpeptidase-like | 1 | 1 |  |
PUA domain-like | alpha/beta knot | 1 | 1 |  |
Glycoside hydrolase/deacetylase | Galactose mutarotase-like | 1 | 1 |  |
alpha-helical ferredoxin | Nucleotide-binding domain | 1 | 1 |  |
Aldolase | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 1 | 1 |  |
Fe,Mn superoxide dismutase (SOD), N-terminal domain | Fe,Mn superoxide dismutase (SOD), C-terminal domain | 1 | 1 |  |
Homodimeric domain of signal transducing histidine kinase | Histidine-containing phosphotransfer domain, HPT domain | 1 | 1 |  |
Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 |  |
Protein kinase-like (PK-like) | Duplicated hybrid motif | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | HRDC-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | FtsH protease domain-like | 1 | 1 |  |
Nucleotidyltransferase | TGS-like | 1 | 1 |  |
"Winged helix" DNA-binding domain | NagB/RpiA/CoA transferase-like | 1 | 1 |  |
Cupredoxins | Class I glutamine amidotransferase-like | 1 | 1 |  |
PurS-like | PurM C-terminal domain-like | 1 | 1 |  |
Nqo1 FMN-binding domain-like | alpha-helical ferredoxin | 1 | 1 |  |
ACT-like | Formyltransferase | 1 | 1 |  |
PurM C-terminal domain-like | PurM C-terminal domain-like | 1 | 1 |  |
Class I glutamine amidotransferase-like | Soluble quinoprotein glucose dehydrogenase | 1 | 1 |  |
Eukaryotic type KH-domain (KH-domain type I) | Nucleic acid-binding proteins | 1 | 1 |  |
Calcium-dependent phosphotriesterase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 |  |
Eukaryotic type KH-domain (KH-domain type I) | HD-domain/PDEase-like | 1 | 1 |  |
Dimeric alpha+beta barrel | Dimeric alpha+beta barrel | 1 | 1 |  |
Cytochrome c | Concanavalin A-like lectins/glucanases | 1 | 1 |  |
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 1 | 1 |  |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 |  |
L21p-like | Rho N-terminal domain-like | 1 | 1 |  |
Cytidine deaminase-like | Dihydrofolate reductase-like | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 |  |
Periplasmic binding protein-like II | Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | 1 |  |
TK C-terminal domain-like | 4Fe-4S ferredoxins | 1 | 1 |  |
P-loop containing nucleoside triphosphate hydrolases | Zinc beta-ribbon | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 1 | 1 |  |
Cna protein B-type domain | OmpA-like | 1 | 1 |  |
DPP6 N-terminal domain-like | Carboxypeptidase regulatory domain-like | 1 | 1 |  |
Quinoprotein alcohol dehydrogenase-like | Cytochrome c | 1 | 1 |  |
DPP6 N-terminal domain-like | DPP6 N-terminal domain-like | 1 | 1 |  |
beta-lactamase/transpeptidase-like | TPR-like | 1 | 1 |  |
PurS-like | PurM N-terminal domain-like | 1 | 1 |  |
Metalloproteases ("zincins"), catalytic domain | alpha/beta-Hydrolases | 1 | 1 |  |
Ribonuclease H-like | RuvA domain 2-like | 1 | 1 |  |
PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 1 | 1 |  |
Ribosomal protein S5 domain 2-like | DNA mismatch repair protein MutL | 1 | 1 |  |
THUMP domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 |  |
Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 1 | 1 |  |
DnaJ/Hsp40 cysteine-rich domain | HSP40/DnaJ peptide-binding domain | 1 | 1 |  |
Nucleotide-binding domain | FAD/NAD(P)-binding domain | 1 | 1 |  |
Starch-binding domain-like | Porins | 1 | 1 |  |
MgtE N-terminal domain-like | CBS-domain pair | 1 | 1 |  |
PH0987 N-terminal domain-like | Cyclophilin-like | 1 | 1 |  |
Galactose mutarotase-like | Glycosyl hydrolase domain | 1 | 1 |  |
Zinc beta-ribbon | DNA primase core | 1 | 1 |  |
DNA repair protein MutS, domain I | DNA repair protein MutS, domain III | 1 | 1 |  |
FAD-binding/transporter-associated domain-like | FAD-linked oxidases, C-terminal domain | 1 | 1 |  |
HMA, heavy metal-associated domain | HAD-like | 1 | 1 |  |
Nicotinate/Quinolinate PRTase N-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 1 | 1 |  |
Glutamine synthetase/guanido kinase | CBS-domain pair | 1 | 1 |  |
DNA ligase/mRNA capping enzyme, catalytic domain | BRCT domain | 1 | 1 |  |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | tRNA-binding arm | 1 | 1 |  |