Domain combination pairs in Protein Data Bank

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

3229 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
Immunoglobulin	Immunoglobulin	11625	47
Retrovirus capsid protein, N-terminal core domain	Retrovirus capsid dimerization domain-like	2873	4
MHC antigen-recognition domain	Immunoglobulin	2142	3
Actin-like ATPase domain	Actin-like ATPase domain	1954	16
PX domain	CAD & PB1 domains	1534	143
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1517	6
Thioredoxin-like	GST C-terminal domain-like	1490	11
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	1334	85
GroEL equatorial domain-like	GroEL apical domain-like	1302	4
GroEL-intermediate domain like	GroEL apical domain-like	1292	2
GroEL equatorial domain-like	GroEL-intermediate domain like	1292	2
(Trans)glycosidases	Glycosyl hydrolase domain	1280	33
Enolase N-terminal domain-like	Enolase C-terminal domain-like	1254	6
Periplasmic binding protein-like II	Clavaminate synthase-like	1217	21
Thiolase-like	Thiolase-like	1154	25
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	1130	2
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	1057	27
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	970	4
Translation proteins SH3-like domain	Nucleic acid-binding proteins	910	4
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	888	6
Periplasmic binding protein-like II	Tudor/PWWP/MBT	883	18
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	868	4
Ribosomal protein L6	Ribosomal protein L6	864	2
GroES-like	NAD(P)-binding Rossmann-fold domains	854	7
Ribonuclease H-like	DNA/RNA polymerases	847	8
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	818	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	816	5
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	809	4
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	809	4
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	784	13
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	768	9
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	761	9
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	751	10
Cupredoxins	Cupredoxins	737	24
	vWA-like	727	77
	Insulin-like	719	2
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	717	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	717	2
Putative DNA-binding domain	P-loop containing nucleoside triphosphate hydrolases	709	1
	Positive stranded ssRNA viruses	689	4
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	689	5
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	663	9
Glutathione synthetase ATP-binding domain-like	PreATP-grasp domain	660	19
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	599	3
	P-loop containing nucleoside triphosphate hydrolases	585	46
Galactose-binding domain-like	(Trans)glycosidases	583	32
RuBisCO, large subunit, small (N-terminal) domain	RuBisCo, C-terminal domain	567	1
Metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	553	9
PsbU/PolX domain-like	Nucleotidyltransferase	544	3
L domain-like	Fibronectin type III	543	31
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	543	27
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	542	14
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	538	3
(Trans)glycosidases	Galactose mutarotase-like	534	15
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	530	2
DNA clamp	DNA clamp	506	4
L9 N-domain-like	Ribosomal protein L9 C-domain	500	2
	C2 domain (Calcium/lipid-binding domain, CaLB)	494	47
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	482	11
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	456	15
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	456	15
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	445	2
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	444	4
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	436	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	433	2
Immunoglobulin	Immunoglobulin	410	2
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	404	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	387	5
PK beta-barrel domain-like	PK C-terminal domain-like	387	5
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	387	5
	ARM repeat	385	19
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	384	3
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	382	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	382	1
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	379	6
	(Trans)glycosidases	373	33
PUA domain-like	SET domain	370	38
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	369	10
Cyclin-like	Cyclin-like	368	8
	(Trans)glycosidases	360	8
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	355	5
Periplasmic binding protein-like II	Periplasmic binding protein-like II	354	13
beta-lactamase/transpeptidase-like	SpoIIaa-like	337	3
(Trans)glycosidases	Chitinase insertion domain	336	12
Bromodomain	FYVE/PHD zinc finger	335	6
Galactose-binding domain-like	Galactose mutarotase-like	335	9
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	334	3
E set domains	(Trans)glycosidases	330	22
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	319	12
Fibronectin type III	Fibronectin type III	316	16
	Galactose-binding domain-like	316	6
Single hybrid motif	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	311	7
beta-Galactosidase/glucuronidase domain	Galactose mutarotase-like	310	3
	beta-Galactosidase/glucuronidase domain	309	3
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	299	12
Sec63 N-terminal domain-like	E set domains	299	12
	gp120 core	299	8
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	297	6
	Galactose mutarotase-like	295	2
PreATP-grasp domain	Rudiment single hybrid motif	291	11
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	291	11
TAF(II)230 TBP-binding fragment	Bromodomain	289	8
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	288	2
Head morphogenesis protein gp7	EB1 dimerisation domain-like	288	10
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	286	10
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	283	5
PLP-binding barrel	Alanine racemase C-terminal domain-like	280	7
LDL receptor-like module	Complement control module/SCR domain	279	30
TPR-like	TPR-like	274	15
post-HMGL domain-like	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	274	2
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	274	2
cAMP-binding domain-like	"Winged helix" DNA-binding domain	273	5
Macro domain-like	Zn-dependent exopeptidases	273	1
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	273	10
Periplasmic binding protein-like I	Periplasmic binding protein-like II	272	10
Protein kinase-like (PK-like)	ARM repeat	270	21
Viral glycoprotein, central and dimerisation domains	E set domains	268	3
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	265	39
Staphylococcal nuclease	Staphylococcal nuclease	264	18
EGF/Laminin	EGF/Laminin	264	34
GroES-like	GroES-like	262	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	262	9
ISP domain	Bet v1-like	259	3
Amine oxidase N-terminal region	Amine oxidase N-terminal region	254	3
Amine oxidase N-terminal region	Amine oxidase catalytic domain	254	3
Bacterial enterotoxins	Superantigen toxins, C-terminal domain	250	4
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	250	6
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	247	5
Metalloproteases ("zincins"), catalytic domain	ARM repeat	247	5
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	247	5
Restriction endonuclease-like	S-adenosyl-L-methionine-dependent methyltransferases	246	11
L domain-like	L domain-like	243	20
ClpP/crotonase	ClpP/crotonase	243	11
ADC-like	Cdc48 domain 2-like	241	4
	EF-G C-terminal domain-like	239	9
E set domains	Glycosyl hydrolase domain	238	10
MIR domain	MIR domain	237	11
Cadherin-like	Cadherin-like	236	25
	Neurotransmitter-gated ion-channel transmembrane pore	232	2
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	228	12
	SET domain	224	14
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	221	13
Trypsin-like serine proteases	PDZ domain-like	219	6
	Ubiquitin-like	215	9
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	214	6
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	214	6
	Ribosomal protein S5 domain 2-like	214	8
Ubiquitin-like	Protein kinase-like (PK-like)	214	6
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	214	7
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	212	5
MIR domain	IP3 receptor type 1 binding core, domain 2	212	10
Sec63 N-terminal domain-like	E set domains	212	27
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	211	4
ADC-like	P-loop containing nucleoside triphosphate hydrolases	211	4
Complement control module/SCR domain	Complement control module/SCR domain	210	19
Translation proteins	EF-G C-terminal domain-like	210	10
Snake toxin-like	Snake toxin-like	209	8
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	209	3
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	209	7
CcmK-like	CcmK-like	208	2
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	207	1
Serum albumin-like	Serum albumin-like	207	1
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	206	7
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	204	3
	RPB6/omega subunit-like	204	1
	C2 domain (Calcium/lipid-binding domain, CaLB)	204	6
	SNARE fusion complex	203	24
	Plexin repeat	203	12
EGF/Laminin	Immunoglobulin	201	7
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	200	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	199	14
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	199	11
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	198	9
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	197	12
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	197	5
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	197	6
Nucleotidylyl transferase	Nudix	197	4
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	196	5
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	195	6
EGF/Laminin	Heme-dependent peroxidases	194	2
Ubiquitin-like	ARM repeat	194	4
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	194	4
Galactose mutarotase-like	Glycosyl hydrolase domain	194	10
Triple coiled coil domain of C-type lectins	C-type lectin-like	193	2
	IP3 receptor type 1 binding core, domain 2	193	6
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	192	4
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	191	1
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	Multidrug efflux transporter AcrB transmembrane domain	191	4
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB transmembrane domain	191	4
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	189	12
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	ARM repeat	188	3
PDZ domain-like	PDZ domain-like	188	6
PUA domain-like	eIF1-like	188	3
Clathrin heavy-chain terminal domain	ARM repeat	188	3
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	187	6
	Nucleic acid-binding proteins	186	1
Viral protein domain	Influenza hemagglutinin (stalk)	186	2
	E set domains	185	16
Restriction endonuclease-like	Restriction endonuclease-like	183	4
Isocitrate/Isopropylmalate dehydrogenase-like	Isocitrate/Isopropylmalate dehydrogenase-like	183	3
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	181	5
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	180	8
	Invasin/intimin cell-adhesion fragments	180	13
Sigma3 and sigma4 domains of RNA polymerase sigma factors	NTF2-like	180	6
E set domains	Chondroitin AC/alginate lyase	179	2
Non-globular alpha+beta subunits of globular proteins	Non-globular alpha+beta subunits of globular proteins	176	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	175	7
	Ribosomal proteins S24e, L23 and L15e	175	2
	NAD(P)-binding Rossmann-fold domains	174	14
Beta-D-glucan exohydrolase, C-terminal domain	Anthrax protective antigen	174	2
SAM/Pointed domain	"Winged helix" DNA-binding domain	173	1
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	173	4
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	173	5
	L30e-like	172	2
Protein kinase-like (PK-like)	EF-hand	172	5
Sialidases	Six-hairpin glycosidases	172	2
Group II dsDNA viruses VP	Group II dsDNA viruses VP	172	2
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	172	5
Integrin alpha N-terminal domain	Integrin alpha N-terminal domain	171	5
	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	171	19
ARM repeat	ARM repeat	170	19
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	170	3
Heme-dependent catalase-like	Class I glutamine amidotransferase-like	167	2
Cytidine deaminase-like	Cytidine deaminase-like	167	1
WD40 repeat-like	WD40 repeat-like	166	19
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	165	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	165	8
Fibrinogen coiled-coil and central regions	Fibrinogen C-terminal domain-like	164	2
Six-hairpin glycosidases	Type I dockerin domain	164	1
	Translation proteins	163	2
Zinc beta-ribbon	Zinc beta-ribbon	163	2
Translation proteins	Ribosomal protein S5 domain 2-like	162	6
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	161	2
	Sigma2 domain of RNA polymerase sigma factors	160	5
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	159	4
Heme-dependent peroxidases	Heme-dependent peroxidases	159	5
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	159	3
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	158	13
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	157	5
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	157	4
HAD-like	Calcium ATPase, transmembrane domain M	157	6
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	157	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	157	5
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	157	6
Calcium ATPase, transduction domain A	HAD-like	157	6
Phage fibre proteins	Virus attachment protein globular domain	156	3
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	156	2
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	156	7
	Concanavalin A-like lectins/glucanases	155	5
Cytochrome c	Cytochrome c	154	8
GFP-like	Bcl-2 inhibitors of programmed cell death	154	12
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	154	3
Positive stranded ssRNA viruses	Positive stranded ssRNA viruses	154	3
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	153	4
Cell wall binding repeat	Cell wall binding repeat	153	3
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	153	4
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	152	4
MIR domain	Concanavalin A-like lectins/glucanases	152	4
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	150	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	150	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	149	5
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	149	2
E set domains	E set domains	149	19
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	149	5
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	148	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	148	2
Chromo domain-like	S-adenosyl-L-methionine-dependent methyltransferases	147	8
	ISP domain	145	3
IP3 receptor type 1 binding core, domain 2	EF-hand	144	3
Concanavalin A-like lectins/glucanases	EF-hand	144	3
	EF-hand	144	3
Concanavalin A-like lectins/glucanases	IP3 receptor type 1 binding core, domain 2	144	3
MIR domain	EF-hand	144	3
	Metalloproteases ("zincins"), catalytic domain	144	7
Photosystem II reaction centre subunit H, transmembrane region	PRC-barrel domain	143	1
	RBP11-like subunits of RNA polymerase	143	2
ACP-like	ACP-like	143	2
Second domain of FERM	PH domain-like	143	12
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	142	1
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	139	6
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	139	3
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	138	1
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	137	3
Coronavirus S2 glycoprotein	Coronavirus S2 glycoprotein	137	6
Viral protein domain	Influenza hemagglutinin (stalk)	137	3
Ubiquitin-like	Zn-binding ribosomal proteins	135	4
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	134	10
Virus ectodomain	Virus ectodomain	134	14
Aldolase	post-HMGL domain-like	133	8
Homeodomain-like	NagB/RpiA/CoA transferase-like	133	1
CoA-dependent acyltransferases	CoA-dependent acyltransferases	133	7
Integrin domains	vWA-like	132	11
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	132	4
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	132	2
ACT-like	ACT-like	131	5
gp120 core	gp120 core	131	5
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	131	2
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	130	3
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	129	3
Carboxypeptidase regulatory domain-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	128	2
	Enolase C-terminal domain-like	128	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	128	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	127	5
PYP-like sensor domain (PAS domain)	GAF domain-like	126	7
Tudor/PWWP/MBT	Tudor/PWWP/MBT	126	5
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	126	5
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	125	9
	TNF-like	123	3
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	123	2
Periplasmic binding protein-like II	Mitochondrial import receptor subunit Tom20	123	16
Concanavalin A-like lectins/glucanases	STI-like	123	2
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	123	11
RNA-binding domain, RBD	RNA-binding domain, RBD	122	6
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	121	2
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	121	2
	Duffy binding domain-like	120	15
Penicillin binding protein dimerisation domain	beta-lactamase/transpeptidase-like	120	5
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	120	2
PDZ domain-like	Fibronectin type III	117	4
BRCT domain	BRCT domain	117	5
SARS receptor-binding domain-like	Coronavirus S2 glycoprotein	117	4
Nucleotidylyl transferase	Nucleotidylyl transferase	115	9
Homing endonucleases	Homing endonucleases	115	5
Plexin repeat	Integrin domains	115	11
	Viral glycoprotein, central and dimerisation domains	114	3
Ricin B-like lectins	Ricin B-like lectins	114	4
Thioredoxin-like	Thioredoxin-like	114	10
PapD-like	Periplasmic chaperone C-domain	113	1
Ubiquitin-like	PH domain-like	113	7
Galactose mutarotase-like	Putative glucosidase YicI, C-terminal domain	112	6
(Trans)glycosidases	Putative glucosidase YicI, C-terminal domain	112	6
Glycosyl hydrolase domain	Putative glucosidase YicI, C-terminal domain	112	6
Leucine zipper domain	TNF-like	112	21
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	111	15
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	111	4
	EF-hand	111	7
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	111	10
Plexin repeat	vWA-like	111	8
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	110	1
	Galactose mutarotase-like	109	4
	LuxS/MPP-like metallohydrolase	109	5
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	108	3
L domain-like	Growth factor receptor domain	108	7
Rudiment single hybrid motif	Single hybrid motif	108	8
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	108	8
PreATP-grasp domain	Single hybrid motif	108	8
Nucleic acid-binding proteins	Nucleic acid-binding proteins	107	17
PA domain	Zn-dependent exopeptidases	107	2
Bacterial luciferase-like	Bacterial luciferase-like	107	6
TNF receptor-like	TNF receptor-like	106	7
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	106	3
	EF-hand	106	11
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	106	2
Bacterial adhesins	Bacterial adhesins	106	5
PurM N-terminal domain-like	PurM C-terminal domain-like	105	5
	Transducin (alpha subunit), insertion domain	105	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	105	13
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	105	1
ISP domain	Bet v1-like	104	17
PA domain	Transferrin receptor-like dimerisation domain	104	1
ISP transmembrane anchor	ISP domain	104	2
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	104	1
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	104	2
Galactose-binding domain-like	Galactose-binding domain-like	103	21
Voltage-gated potassium channels	E set domains	103	3
	ssDNA viruses	103	2
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	103	3
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like I	103	1
Aspartate/glutamate racemase	Aspartate/glutamate racemase	102	5
TPR-like	"Winged helix" DNA-binding domain	102	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	102	1
N-terminal Zn binding domain of HIV integrase	Ribonuclease H-like	102	3
CheY-like	C-terminal effector domain of the bipartite response regulators	102	2
Concanavalin A-like lectins/glucanases	Sialidases	102	4
Nucleotide-binding domain	FAD/NAD(P)-binding domain	102	4
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	101	6
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	101	17
Methyl-coenzyme M reductase subunits	Methyl-coenzyme M reductase alpha and beta chain C-terminal domain	100	2
ABC transporter transmembrane region	ABC transporter transmembrane region	99	5
TATA-box binding protein-like	TATA-box binding protein-like	99	3
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	99	2
Ubiquitin-like	Second domain of FERM	99	7
JAB1/MPN domain	JAB1/MPN domain	98	11
HAD-like	alpha/beta-Hydrolases	98	1
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	98	2
	Single hybrid motif	98	8
Lysozyme-like	Family A G protein-coupled receptor-like	97	9
SH3-domain	CAD & PB1 domains	97	4
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	97	3
SRCR-like	Trypsin-like serine proteases	97	8
Myosin rod fragments	Myosin rod fragments	96	7
GAF domain-like	GAF domain-like	96	10
	Ribosomal protein S5 domain 2-like	95	7
ADP-ribosylation	Diphtheria toxin, middle domain	95	4
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	95	14
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	95	4
C-type lectin-like	C-type lectin-like	94	3
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	94	12
	Clavaminate synthase-like	93	7
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	93	2
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	93	2
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	92	4
	Aldolase	92	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	91	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	91	4
	post-HMGL domain-like	90	3
Bacterial immunoglobulin/albumin-binding domains	Positive stranded ssRNA viruses	90	1
p53-like transcription factors	E set domains	89	3
POZ domain	Skp1 dimerisation domain-like	89	1
SH3-domain	SH2 domain	89	11
	PAP/OAS1 substrate-binding domain	89	7
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	89	7
PreATP-grasp domain	PreATP-grasp domain	88	8
	Bromodomain	87	5
P-loop containing nucleoside triphosphate hydrolases	MOP-like	87	1
	GST C-terminal domain-like	87	5
DBL homology domain (DH-domain)	PH domain-like	87	13
A virus capsid protein alpha-helical domain	Viral protein domain	86	1
Terpenoid cyclases/Protein prenyltransferases	Terpenoid synthases	86	4
Galactose-binding domain-like	Heparin-binding domain from vascular endothelial growth factor	86	3
beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	85	7
	PreATP-grasp domain	84	6
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	84	5
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	83	6
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	83	2
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	83	2
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	82	7
PH domain-like	C-terminal domain of PLC-beta	82	5
	Ribulose-phoshate binding barrel	82	3
	Fic-like	82	4
Family A G protein-coupled receptor-like	Cytochromes	82	4
Voltage-gated potassium channels	Voltage-gated potassium channels	82	14
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	82	3
	Ricin B-like lectins	81	6
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	81	1
Midkine	Midkine	81	6
Class II aaRS ABD-related	C-terminal domain of ProRS	81	1
Alpha-macroglobulin receptor domain	TIMP-like	80	8
	Major capsid protein VP5	80	2
	Terpenoid cyclases/Protein prenyltransferases	80	6
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	80	1
Nucleotide-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	79	1
	L,D-transpeptidase catalytic domain-like	79	3
Ubiquitin-like	Ubiquitin-like	78	3
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	78	2
Starch-binding domain-like	(Trans)glycosidases	78	6
FMN-binding split barrel	UbiD C-terminal domain-like	78	2
Starch-binding domain-like	E set domains	77	5
Bacterial fluorinating enzyme, N-terminal domain	Bacterial fluorinating enzyme, C-terminal domain	77	1
GLA-domain	EGF/Laminin	77	4
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	77	1
Thiolase-like	FabD/lysophospholipase-like	77	11
Rho N-terminal domain-like	Nucleic acid-binding proteins	77	2
TATA-box binding protein-like	DNA-glycosylase	77	1
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	76	2
SH2 domain	SH2 domain	76	7
lambda integrase-like, N-terminal domain	DNA breaking-rejoining enzymes	76	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	76	2
Starch-binding domain-like	Glycosyl hydrolase domain	76	4
Class I glutamine amidotransferase-like	LD-carboxypeptidase A C-terminal domain-like	76	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	76	4
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	76	2
	Ribosomal protein S19	76	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	76	2
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	75	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	75	4
Polo-box domain	Polo-box domain	75	2
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	75	5
Leucine zipper domain	Leucine zipper domain	75	9
Periplasmic binding protein-like II	Voltage-gated potassium channels	74	7
(Trans)glycosidases	Hyaluronidase post-catalytic domain-like	74	3
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	74	2
post-HMGL domain-like	Single hybrid motif	74	4
Aldolase	Single hybrid motif	74	4
PUA domain-like	eIF1-like	74	4
beta-N-acetylhexosaminidase-like domain	Hyaluronidase post-catalytic domain-like	74	3
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	74	4
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	73	2
Thioredoxin-like	NHL repeat	73	2
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	73	3
	Terpenoid cyclases/Protein prenyltransferases	73	11
Class II aaRS and biotin synthetases	C-terminal domain of transcriptional repressors	73	2
Acyl-CoA N-acyltransferases (Nat)	SCP-like	73	2
	"Winged helix" DNA-binding domain	72	8
TRAF domain-like	POZ domain	71	9
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	71	5
SH2 domain	Protein kinase-like (PK-like)	71	6
PRTase-like	PRTase-like	71	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	70	2
Rho N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	70	1
	Di-copper centre-containing domain	70	3
Periplasmic binding protein-like I	Voltage-gated potassium channels	70	6
Bacteriophage trimeric proteins domain	Phage fibre proteins	69	1
Homeodomain-like	FAD-linked reductases, C-terminal domain	69	2
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	69	7
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	69	1
Bacteriophage trimeric proteins domain	Virus attachment protein globular domain	69	1
MoeA N-terminal region -like	MoeA C-terminal domain-like	69	1
Homeodomain-like	FAD/NAD(P)-binding domain	69	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	69	1
Alkaline phosphatase-like	His-Me finger endonucleases	69	4
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	68	11
Galactose mutarotase-like	Six-hairpin glycosidases	68	4
Glycosyl hydrolase domain	Glycosyl hydrolase domain	68	1
beta-sandwich domain of Sec23/24	vWA-like	67	4
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	67	4
	4Fe-4S ferredoxins	67	4
PH domain-like	Ras GEF	67	11
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	67	4
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	67	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	67	3
vWA-like	Helical domain of Sec23/24	67	4
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	67	4
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	67	4
Phospholipase D/nuclease	Phospholipase D/nuclease	66	3
	Alpha-macroglobulin receptor domain	66	9
Coronavirus S2 glycoprotein	Fibritin	66	1
RNI-like	RNI-like	66	12
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	66	4
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	66	3
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	66	8
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	66	6
SARS receptor-binding domain-like	Fibritin	66	1
EF-hand	SH2 domain	65	3
Protein kinase-like (PK-like)	EF-hand	65	3
	UDP-Glycosyltransferase/glycogen phosphorylase	65	1
Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclases/Protein prenyltransferases	65	3
N-terminal domain of cbl (N-cbl)	EF-hand	65	3
N-terminal domain of cbl (N-cbl)	SH2 domain	65	3
Protein prenylyltransferase	UDP-Glycosyltransferase/glycogen phosphorylase	65	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	64	2
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	64	2
GFP-like	GFP-like	64	9
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	64	5
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	64	2
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	64	3
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	64	2
Protein kinase-like (PK-like)	SH3-domain	64	4
DeoB insert domain-like	Alkaline phosphatase-like	64	1
Immunoglobulin-binding domains	NHL repeat	64	5
DEATH domain	P-loop containing nucleoside triphosphate hydrolases	63	5
Mechanosensitive channel protein MscS (YggB), transmembrane region	Mechanosensitive channel protein MscS (YggB), C-terminal domain	63	2
Integrin domains	EGF/Laminin	63	2
Sm-like ribonucleoproteins	Mechanosensitive channel protein MscS (YggB), C-terminal domain	63	2
Rad51 N-terminal domain-like	Ribosomal protein L32e	63	1
EF-hand	EF-hand	63	11
tRNA-binding arm	Class II aaRS and biotin synthetases	63	5
Ribonuclease H-like	DNA-binding domain of retroviral integrase	63	3
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	63	2
Di-copper centre-containing domain	E set domains	62	5
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	62	2
PreATP-grasp domain	Aldolase	62	2
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	62	8
Rudiment single hybrid motif	Aldolase	62	2
PreATP-grasp domain	post-HMGL domain-like	62	2
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	62	3
Hairpin loop containing domain-like	Kringle-like	62	3
Flavoproteins	Riboflavin synthase domain-like	62	3
Rudiment single hybrid motif	post-HMGL domain-like	62	2
Glutathione synthetase ATP-binding domain-like	Aldolase	62	2
Zn-finger domain of Sec23/24	beta-sandwich domain of Sec23/24	61	3
	Type II DNA topoisomerase	61	6
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	61	3
Zn-finger domain of Sec23/24	vWA-like	61	3
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	61	2
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	61	3
	EF-G C-terminal domain-like	61	3
	LeuD/IlvD-like	61	3
Homeodomain-like	Homeodomain-like	60	11
WW domain	Periplasmic binding protein-like II	60	2
Hemocyanin, N-terminal domain	E set domains	60	4
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	60	2
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	60	3
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	60	3
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	60	5
Photosystem I subunits PsaA/PsaB	Photosystem I subunits PsaA/PsaB	60	5
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	60	3
Hemocyanin, N-terminal domain	Di-copper centre-containing domain	60	4
Sema domain	Plexin repeat	59	7
Somatomedin B domain	Somatomedin B domain	59	3
Somatomedin B domain	His-Me finger endonucleases	59	3
alpha/beta-Hydrolases	Galactose-binding domain-like	59	3
(Trans)glycosidases	(Trans)glycosidases	59	8
Acetyl-CoA synthetase-like	alpha/beta-Hydrolases	59	4
Somatomedin B domain	Alkaline phosphatase-like	59	3
Integrin alpha N-terminal domain	Integrin domains	59	7
Formyltransferase	FMT C-terminal domain-like	58	3
	Translation proteins	58	12
RNase III domain-like	dsRNA-binding domain-like	58	5
	Single hybrid motif	58	2
CBS-domain pair	CBS-domain pair	57	3
	TIMP-like	57	6
alpha/beta-Hydrolases	Influenza virus matrix protein M1	57	1
Carbohydrate binding domain	(Trans)glycosidases	57	3
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	57	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	57	3
RmlC-like cupins	RmlC-like cupins	57	1
Sialidases	Oligoxyloglucan reducing end-specific cellobiohydrolase	56	2
Acetyl-CoA synthetase-like	ACP-like	56	5
	Probable ACP-binding domain of malonyl-CoA ACP transacylase	56	13
Carbohydrate binding domain	(Trans)glycosidases	56	5
Growth factor receptor domain	Growth factor receptor domain	56	2
Folate-binding domain	Aminomethyltransferase beta-barrel domain	55	3
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	55	3
(Trans)glycosidases	Ricin B-like lectins	55	4
E set domains	Transglutaminase, two C-terminal domains	55	2
E set domains	Cysteine proteinases	55	2
Multiheme cytochromes	Multiheme cytochromes	55	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	55	2
	Zn-dependent exopeptidases	55	3
Cysteine proteinases	Transglutaminase, two C-terminal domains	55	2
Carbamate kinase-like	ACT-like	55	2
lambda repressor-like DNA-binding domains	RmlC-like cupins	55	2
beta-lactamase/transpeptidase-like	Penicillin-binding protein associated domain	55	2
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	55	2
Subtilisin-like	Galactose-binding domain-like	54	3
	cAMP-binding domain-like	54	5
(Trans)glycosidases	Class I glutamine amidotransferase-like	54	4
tRNA-intron endonuclease catalytic domain-like	tRNA-intron endonuclease catalytic domain-like	54	5
Galactose mutarotase-like	Anthrax protective antigen	54	6
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	54	1
FucI/AraA N-terminal and middle domains	FucI/AraA C-terminal domain-like	54	1
N-terminal domain of DnaB helicase	P-loop containing nucleoside triphosphate hydrolases	54	1
Terpenoid cyclases/Protein prenyltransferases	TIMP-like	53	5
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	53	3
	PH domain-like	53	10
Voltage-gated potassium channels	cAMP-binding domain-like	52	6
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	52	2
HAD-like	HAD-like	52	3
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	52	1
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	52	1
	Cysteine proteinases	52	9
N-terminal Zn binding domain of HIV integrase	DNA-binding domain of retroviral integrase	52	2
Ribbon-helix-helix	ACT-like	52	1
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	52	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	52	1
NAD(P)-binding Rossmann-fold domains	Thiolase-like	52	5
TSP-1 type 1 repeat	LDL receptor-like module	51	5
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	51	6
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	51	3
Heterotrimerisation domain of extracellular hemoglobin linker subunits	Extracellular hemoglobin linker subunit, receptor domain	51	3
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	51	4
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	51	4
Heterotrimerisation domain of extracellular hemoglobin linker subunits	LDL receptor-like module	51	3
LDL receptor-like module	Extracellular hemoglobin linker subunit, receptor domain	51	3
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	51	4
Galactose-binding domain-like	Growth factor receptor domain	50	3
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	50	4
	Protein kinase-like (PK-like)	50	13
	SET domain	50	5
RNI-like	L domain-like	50	12
	PH0987 N-terminal domain-like	50	1
	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	50	4
MurCD N-terminal domain	MurD-like peptide ligases, catalytic domain	50	2
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	50	2
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	50	3
S-adenosyl-L-methionine-dependent methyltransferases	DNA methylase specificity domain	50	4
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	50	2
Cyclophilin-like	TPR-like	50	1
SH2 domain	ARM repeat	50	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	50	3
	Class I glutamine amidotransferase-like	50	2
Iron-dependent repressor protein, dimerization domain	C-terminal domain of transcriptional repressors	49	1
lambda repressor-like DNA-binding domains	TPR-like	49	1
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	49	8
Phosphofructokinase	Phosphofructokinase	49	3
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	4Fe-4S ferredoxins	49	2
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	49	3
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	49	4
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	49	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	49	5
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	49	2
C-type lectin-like	Aerolisin/ETX pore-forming domain	49	1
Carbohydrate binding domain	Chitinase insertion domain	49	3
4Fe-4S ferredoxins	Nitrite and sulphite reductase 4Fe-4S domain-like	48	1
Translational machinery components	L30e-like	48	3
Formate/glycerate dehydrogenase catalytic domain-like	Formate/glycerate dehydrogenase catalytic domain-like	48	2
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	48	2
	RCC1/BLIP-II	48	5
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	48	3
Metalloproteases ("zincins"), catalytic domain	Clostridium neurotoxins, "coiled-coil" domain	48	5
Nitrite/Sulfite reductase N-terminal domain-like	4Fe-4S ferredoxins	48	1
FabD/lysophospholipase-like	FabD/lysophospholipase-like	48	4
Metallo-hydrolase/oxidoreductase	Flavoproteins	47	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	47	4
Nucleotidylyl transferase	ValRS/IleRS/LeuRS editing domain	47	4
Glycosyl hydrolase domain	Galactose-binding domain-like	47	6
Protease propeptides/inhibitors	Subtilisin-like	47	5
SH2 domain	(Phosphotyrosine protein) phosphatases II	47	2
Galactose mutarotase-like	Hyaluronate lyase-like, C-terminal domain	47	4
Chondroitin AC/alginate lyase	Hyaluronate lyase-like, C-terminal domain	47	4
	Terpenoid cyclases/Protein prenyltransferases	47	1
E set domains	Chitinase insertion domain	47	2
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	47	6
LDL receptor-like module	Growth factor receptor domain	47	3
TSP-1 type 1 repeat	Growth factor receptor domain	47	3
Virus ectodomain	Leucine zipper domain	47	7
Chondroitin AC/alginate lyase	Galactose mutarotase-like	47	4
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	46	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	46	2
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	46	2
	GroES-like	46	3
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	46	2
	Alpha-macroglobulin receptor domain	46	8
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	46	2
PUA domain-like	Nucleotidylyl transferase	46	3
PreATP-grasp domain	Methylglyoxal synthase-like	46	2
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	46	2
Spectrin repeat	Spectrin repeat	46	8
Galactose mutarotase-like	CBD9-like	46	2
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	46	2
PreATP-grasp domain	PreATP-grasp domain	46	2
Periplasmic binding protein-like II	GlnB-like	45	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	TK C-terminal domain-like	45	2
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Thiamin diphosphate-binding fold (THDP-binding)	45	2
Rad51 N-terminal domain-like	Rad51 N-terminal domain-like	45	5
Ribosomal L27 protein-like	Nucleic acid-binding proteins	45	3
Fibre shaft of virus attachment proteins	Virus attachment protein globular domain	45	3
FabD/lysophospholipase-like	Thioesterase/thiol ester dehydrase-isomerase	45	3
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	45	1
Fibronectin type III	Immunoglobulin	45	11
Di-copper centre-containing domain	C-terminal domain of mollusc hemocyanin	45	7
PDZ domain-like	ClpP/crotonase	45	4
RING/U-box	RING/U-box	45	9
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	45	4
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	45	1
	Thioesterase/thiol ester dehydrase-isomerase	45	3
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	45	2
cAMP-binding domain-like	cAMP-binding domain-like	44	5
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	44	2
Rho N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	44	13
Cytochrome c	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	44	1
Plant lectins/antimicrobial peptides	Plant lectins/antimicrobial peptides	44	3
RuvA domain 2-like	BRCT domain	44	4
Methylglyoxal synthase-like	Cytidine deaminase-like	44	1
	Zinc beta-ribbon	44	7
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	43	2
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	43	5
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	43	2
	HydA/Nqo6-like	43	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	43	7
Integrin domains	Integrin domains	43	7
WW domain	FKBP-like	43	2
Arabinanase/levansucrase/invertase	Ricin B-like lectins	43	3
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	43	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	43	4
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	43	4
Oxidoreductase molybdopterin-binding domain	E set domains	43	3
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	42	5
"Winged helix" DNA-binding domain	GAF domain-like	42	2
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SET domain	42	1
DsbC/DsbG N-terminal domain-like	Thioredoxin-like	42	1
Nucleic acid-binding proteins	RuvA domain 2-like	42	7
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	42	2
	Prion-like	42	2
Metalloproteases ("zincins"), catalytic domain	Adenylylcyclase toxin (the edema factor)	42	1
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	42	4
Kringle-like	Kringle-like	42	12
	Aspartate/glutamate racemase	42	3
TK C-terminal domain-like	4Fe-4S ferredoxins	41	1
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	41	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	41	3
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	41	3
L domain-like	E set domains	41	6
Thiamin diphosphate-binding fold (THDP-binding)	4Fe-4S ferredoxins	41	1
PAZ domain	Ribonuclease H-like	41	4
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	41	2
Glycosyl hydrolase domain	Glycosyl hydrolase domain	41	3
Actin depolymerizing proteins	Actin depolymerizing proteins	40	4
PAZ domain	dsRNA-binding domain-like	40	15
Integrin domains	EGF/Laminin	40	8
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	40	2
MurCD N-terminal domain	MurD-like peptide ligases, peptide-binding domain	40	1
PUA domain-like	alpha/beta knot	40	1
Ferritin-like	Rubredoxin-like	40	1
Protein kinase-like (PK-like)	KA1-like	39	3
Periplasmic binding protein-like II	DEATH domain	39	2
EspE N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	39	2
Lysozyme-like	Family A G protein-coupled receptor-like	39	6
	RNA-binding domain, RBD	39	5
Peptidylarginine deiminase Pad4, middle domain	Pentein	39	1
Cupredoxins	Peptidylarginine deiminase Pad4, middle domain	39	1
Sialidases	E set domains	39	2
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease catalytic domain-like	39	4
	TPR-like	39	4
Sec63 N-terminal domain-like	E set domains	39	7
Cupredoxins	Pentein	39	1
Plexin repeat	EGF/Laminin	38	6
SGNH hydrolase	Viral protein domain	38	1
Phage fibre proteins	Receptor-binding domain of short tail fibre protein gp12	38	2
Nitrous oxide reductase, N-terminal domain	Cupredoxins	38	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	38	2
	Purine and uridine phosphorylases	38	1
FMN-linked oxidoreductases	Ribulose-phoshate binding barrel	38	5
PheT/TilS domain	Putative DNA-binding domain	38	4
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	38	2
Cyclophilin-like	Cyclophilin-like	38	6
	Terpenoid cyclases/Protein prenyltransferases	38	9
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	38	1
Metalloproteases ("zincins"), catalytic domain	Concanavalin A-like lectins/glucanases	38	3
HIN-2000 domain-like	HIN-2000 domain-like	38	1
(Trans)glycosidases	Anthrax protective antigen	38	2
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	37	1
Urease metallochaperone UreE, N-terminal domain	Urease metallochaperone UreE, C-terminal domain	37	1
Putative DNA-binding domain	Putative DNA-binding domain	37	3
	Glycosyl hydrolase domain	37	3
GAF domain-like	GAF domain-like	37	8
	TIMP-like	37	5
	SAM/Pointed domain	37	9
SIS domain	SIS domain	37	1
Trypsin-like serine proteases	P-loop containing nucleoside triphosphate hydrolases	37	2
	Porins	37	4
NAD(P)-binding Rossmann-fold domains	ACT-like	37	4
vWA-like	EGF/Laminin	37	5
vWA-like	Integrin beta tail domain	36	4
Plexin repeat	Integrin beta tail domain	36	4
Initiation factor IF2/eIF5b, domain 3	Translation proteins	36	5
Copper amine oxidase, domain N	Amine oxidase catalytic domain	36	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	36	2
Cytochrome f, large domain	Rudiment single hybrid motif	36	3
	Sec63 N-terminal domain-like	36	5
Nqo1 middle domain-like	Nqo1C-terminal domain-like	36	2
ACP-like	alpha/beta-Hydrolases	36	2
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	36	6
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	36	2
4Fe-4S ferredoxins	Cna protein B-type domain	36	1
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	36	2
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	36	2
Nucleic acid-binding proteins	TPR-like	36	3
"Winged helix" DNA-binding domain	NAD(P)-binding Rossmann-fold domains	36	1
Integrin domains	Integrin beta tail domain	36	4
PHM/PNGase F	PHM/PNGase F	36	3
Oligoxyloglucan reducing end-specific cellobiohydrolase	Oligoxyloglucan reducing end-specific cellobiohydrolase	36	8
	Nucleotidylyl transferase	36	7
EGF/Laminin	Integrin beta tail domain	36	4
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	36	2
Immunoglobulin	E set domains	36	8
GINS helical bundle-like	PriA/YqbF domain	36	3
RING/U-box	Quinoprotein alcohol dehydrogenase-like	36	1
E set domains	"Winged helix" DNA-binding domain	36	6
Copper amine oxidase, domain N	Amine oxidase N-terminal region	36	1
Methylglyoxal synthase-like	Cytidine deaminase-like	36	6
	Arabinanase/levansucrase/invertase	36	3
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	36	5
Sialidases	Sialidases	35	2
	Head and neck region of the ectodomain of NDV fusion glycoprotein	35	5
Putative DNA-binding domain	Class II aaRS and biotin synthetases	35	3
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	35	3
TRAF domain-like	POZ domain	35	4
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	35	4
PheT/TilS domain	Class II aaRS and biotin synthetases	35	3
Cytochrome f, large domain	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	35	3
Virus ectodomain	Head and neck region of the ectodomain of NDV fusion glycoprotein	35	5
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	35	3
P-loop containing nucleoside triphosphate hydrolases	E set domains	35	5
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	35	4
"Winged helix" DNA-binding domain	GntR ligand-binding domain-like	35	1
Ran binding protein zinc finger-like	"Winged helix" DNA-binding domain	35	7
Clostridium neurotoxins, "coiled-coil" domain	Concanavalin A-like lectins/glucanases	35	2
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	35	3
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	35	5
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	35	5
FAD-linked oxidoreductase	ALDH-like	35	4
PH domain-like	Protein kinase-like (PK-like)	35	3
Metalloproteases ("zincins"), catalytic domain	ADP-ribosylation	35	3
	Nop domain	35	5
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	35	5
UROD/MetE-like	UROD/MetE-like	34	4
Sec7 domain	P-loop containing nucleoside triphosphate hydrolases	34	5
FYVE/PHD zinc finger	FYVE/PHD zinc finger	34	4
Lysozyme-like	beta-lactamase/transpeptidase-like	34	8
E set domains	Six-hairpin glycosidases	34	6
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	34	3
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	34	1
Spermadhesin, CUB domain	Spermadhesin, CUB domain	34	5
NTF2-like	beta-lactamase/transpeptidase-like	34	1
Cell wall binding repeat	Cell wall binding repeat	34	10
EF-hand	EF-hand	34	6
	PB2 C-terminal domain-like	34	6
lambda repressor-like DNA-binding domains	Homeodomain-like	34	3
	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	34	1
Triger factor/SurA peptide-binding domain-like	FKBP-like	34	5
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	34	2
Clathrin heavy-chain terminal domain	ARM repeat	34	3
NTF2-like	Penicillin binding protein dimerisation domain	34	1
	Trypsin-like serine proteases	33	4
Cytochrome b5-like heme/steroid binding domain	FMN-linked oxidoreductases	33	2
"Winged helix" DNA-binding domain	C-terminal domain of arginine repressor	33	1
Thioredoxin-like	FAD/NAD(P)-binding domain	33	3
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	33	3
Phage tail proteins	Phage tail proteins	33	3
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	33	3
ADP-ribosylation	ADP-ribosylation	33	2
S-adenosyl-L-methionine-dependent methyltransferases	DNA/RNA polymerases	33	1
Aerolisin/ETX pore-forming domain	Galactose-binding domain-like	33	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	33	4
Complement control module/SCR domain	Trypsin-like serine proteases	33	3
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	33	14
GFP-like	EF-hand	33	5
	alpha/beta-Hydrolases	33	3
alpha-helical ferredoxin	Nucleotide-binding domain	33	3
	FMN-linked oxidoreductases	33	1
"Winged helix" DNA-binding domain	NosL/MerB-like	33	1
	C2 domain (Calcium/lipid-binding domain, CaLB)	33	2
Calcium-dependent phosphotriesterase	WD40 repeat-like	32	2
PTS-regulatory domain, PRD	PTS-regulatory domain, PRD	32	3
Nucleotide-binding domain	Nucleotide-binding domain	32	3
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	32	1
Ubiquitin-like	RING/U-box	32	4
Ribonuclease H-like	JAB1/MPN domain	32	3
Periplasmic binding protein-like II	Lysozyme-like	32	1
Translation proteins	Translation proteins	32	4
Galactose oxidase, central domain	FYVE/PHD zinc finger	32	2
LDL receptor-like module	LDL receptor-like module	32	9
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	32	2
Protease propeptides/inhibitors	Zn-dependent exopeptidases	32	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	32	8
Pseudouridine synthase	PUA domain-like	32	2
Ribonuclease H-like	Ribonuclease H-like	32	3
E set domains	3-carboxy-cis,cis-mucoante lactonizing enzyme	31	2
EF-hand	PLC-like phosphodiesterases	31	5
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	31	5
FnI-like domain	FnI-like domain	31	3
	6-phosphogluconate dehydrogenase C-terminal domain-like	31	3
	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	31	3
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	31	5
Periplasmic binding protein-like II	Hormone receptor domain	31	3
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	31	5
JAB1/MPN domain	JAB1/MPN domain	31	3
FMN-linked oxidoreductases	Nucleotide-binding domain	31	2
	Ankyrin repeat	31	7
Cupredoxins	Peptidylarginine deiminase Pad4, middle domain	31	5
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	31	3
HAD-like	P-loop containing nucleoside triphosphate hydrolases	31	2
Macro domain-like	Macro domain-like	31	3
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	31	3
P-loop containing nucleoside triphosphate hydrolases	Nucleotidylyl transferase	31	3
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	31	5
Calcium ATPase, transduction domain A	HAD-like	31	7
Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, C-terminal domains	30	1
	PYP-like sensor domain (PAS domain)	30	3
	Ribokinase-like	30	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	30	3
Leucine zipper domain	Head morphogenesis protein gp7	30	2
	EF-G C-terminal domain-like	30	5
Pheromone-binding domain of LuxR-like quorum-sensing transcription factors	C-terminal effector domain of the bipartite response regulators	30	1
Ribonuclease H-like	HRDC-like	30	1
HSP90 C-terminal domain	Cna protein B-type domain	30	5
	GAF domain-like	30	3
Arabinanase/levansucrase/invertase	Ricin B-like lectins	30	1
Thiamin phosphate synthase	Ribokinase-like	30	1
Cna protein B-type domain	Cna protein B-type domain	30	10
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	30	2
HMG-box	HMG-box	30	2
Nucleotide cyclase	Nucleotide cyclase	30	1
Concanavalin A-like lectins/glucanases	Sialidases	30	5
DEATH domain	WD40 repeat-like	30	1
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	30	2
Multiheme cytochromes	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	29	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	29	2
Metalloproteases ("zincins"), catalytic domain	STI-like	29	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	29	2
Spermadhesin, CUB domain	EGF/Laminin	29	3
Trefoil	Glycosyl hydrolase domain	29	1
TSP-1 type 1 repeat	LDL receptor-like module	29	2
	Immunoglobulin-binding domains	29	4
Nucleotidylyl transferase	Ribosomal protein L25-like	29	5
Trefoil	Putative glucosidase YicI, C-terminal domain	29	1
Clostridium neurotoxins, "coiled-coil" domain	STI-like	29	1
	cAMP-binding domain-like	29	2
Anaphylotoxins (complement system)	Terpenoid cyclases/Protein prenyltransferases	29	4
Nucleotidylyl transferase	Riboflavin kinase-like	29	1
	Plexin repeat	29	5
Trefoil	Galactose mutarotase-like	29	1
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	29	3
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	29	5
Metalloproteases ("zincins"), catalytic domain	beta-Roll	29	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	29	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	29	2
Multiheme cytochromes	FAD/NAD(P)-binding domain	29	1
Metallo-hydrolase/oxidoreductase	SCP-like	29	2
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	29	2
Trefoil	(Trans)glycosidases	29	1
vWA-like	SPOC domain-like	28	3
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	28	4
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	28	2
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	28	2
Cullin homology domain	"Winged helix" DNA-binding domain	28	3
RuvA domain 2-like	DNA helicase RuvA subunit, C-terminal domain	28	2
"Helical backbone" metal receptor	Nitrile hydratase alpha chain	28	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	28	2
"Winged helix" DNA-binding domain	Chorismate lyase-like	28	1
Midkine	Midkine	28	5
Protease propeptides/inhibitors	Subtilisin-like	28	3
Rudiment single hybrid motif	ClpP/crotonase	28	4
Regulator of G-protein signaling, RGS	PH domain-like	28	1
Zinc beta-ribbon	Cyclin-like	28	3
	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	28	1
PreATP-grasp domain	ClpP/crotonase	28	4
	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	28	5
Nucleic acid-binding proteins	DNA helicase RuvA subunit, C-terminal domain	28	2
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	28	2
Voltage-gated potassium channels	TrkA C-terminal domain-like	28	2
TrkA C-terminal domain-like	TrkA C-terminal domain-like	28	2
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphohistidine domain	28	2
Cell wall binding repeat	(Trans)glycosidases	28	4
	Nucleotide cyclase	27	2
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	27	1
Nucleic acid-binding proteins	Putative DNA-binding domain	27	2
SH2 domain	RING/U-box	27	1
S-adenosyl-L-methionine-dependent methyltransferases	EndoU-like	27	1
Ribonuclease H-like	mu transposase, C-terminal domain	27	4
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	27	1
Glu-tRNAGln amidotransferase C subunit	Nucleotidylyl transferase	27	3
Putative DNA-binding domain	Anticodon-binding domain of PheRS	27	2
Succinyl-CoA synthetase domains	Succinyl-CoA synthetase domains	27	3
N-terminal domain of cbl (N-cbl)	RING/U-box	27	1
PheT/TilS domain	Anticodon-binding domain of PheRS	27	2
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	27	3
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	27	3
Ubiquitin-like	RING/U-box	27	5
OMPA-like	OMPA-like	27	5
Bacterial immunoglobulin/albumin-binding domains	Bacterial immunoglobulin/albumin-binding domains	27	7
PGBD-like	Metalloproteases ("zincins"), catalytic domain	27	5
Nucleic acid-binding proteins	PheT/TilS domain	27	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	27	3
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	27	3
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	27	1
P-loop containing nucleoside triphosphate hydrolases	RNI-like	27	3
EF-hand	RING/U-box	27	1
N-terminal domain of bifunctional PutA protein	FAD-linked oxidoreductase	27	5
CRISPR-associated protein	CRISPR-associated protein	27	2
L domain-like	Immunoglobulin	27	4
Bacterial adhesins	Cna protein B-type domain	27	8
Galactose-binding domain-like	E set domains	27	4
Nucleic acid-binding proteins	Anticodon-binding domain of PheRS	27	2
POZ domain	Voltage-gated potassium channels	26	3
Bacillus cereus metalloprotein-like	Bacillus cereus metalloprotein-like	26	1
E set domains	AMPKBI-like	26	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	26	3
Cytidine deaminase-like	Dihydrofolate reductase-like	26	1
	DHH phosphoesterases	26	2
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	26	2
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	26	2
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	26	2
	Inhibitor of apoptosis (IAP) repeat	26	1
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	26	6
	Immunoglobulin-binding domains	26	2
E set domains	Transglutaminase, two C-terminal domains	26	2
Calcium-dependent phosphotriesterase	Calcium-dependent phosphotriesterase	26	2
	EF-hand	26	2
Single hybrid motif	ClpP/crotonase	26	3
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	26	2
Adhesin YadA, collagen-binding domain	Leucine zipper domain	26	7
Di-copper centre-containing domain	Di-copper centre-containing domain	26	5
Cytokine	Cytokine	26	2
ACP-like	NAD(P)-binding Rossmann-fold domains	26	3
PYP-like sensor domain (PAS domain)	C-terminal effector domain of the bipartite response regulators	26	2
Uteroglobin-like	Uteroglobin-like	26	1
Six-hairpin glycosidases	Carbohydrate-binding domain	26	1
Nucleic acid-binding proteins	GAD domain-like	26	1
Metalloproteases ("zincins"), catalytic domain	SNARE fusion complex	26	2
C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	26	5
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	26	1
Class II aaRS and biotin synthetases	GAD domain-like	26	1
Retrovirus capsid protein, N-terminal core domain	Retrovirus zinc finger-like domains	25	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	25	2
GFP-like	Bcl-2 inhibitors of programmed cell death	25	4
Thioesterase/thiol ester dehydrase-isomerase	NAD(P)-binding Rossmann-fold domains	25	3
DEATH domain	DEATH domain	25	3
	UROD/MetE-like	25	4
Chromo domain-like	Chromo domain-like	25	7
ADC-like	P-loop containing nucleoside triphosphate hydrolases	25	4
SET domain	TPR-like	25	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	25	4
	F1F0 ATP synthase subunit A	25	1
Ribonuclease H-like	HRDC-like	25	4
delta-Endotoxin (insectocide), N-terminal domain	Galactose-binding domain-like	25	4
Class II aaRS and biotin synthetases	SufE/NifU	25	1
	Fibronectin type III	25	5
GreA transcript cleavage protein, N-terminal domain	FKBP-like	25	1
HIT-like	HIT-like	25	3
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	25	11
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	25	3
	Ribosomal protein L25-like	25	4
Bacteriophage trimeric proteins domain	C-type lectin-like	25	10
Acid proteases	Acid proteases	25	1
Ribulose-phoshate binding barrel	Thioesterase/thiol ester dehydrase-isomerase	24	2
	Ribulose-phoshate binding barrel	24	2
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	24	3
RING/U-box	WD40 repeat-like	24	1
Thioesterase/thiol ester dehydrase-isomerase	Thiolase-like	24	2
EF-hand	Inorganic pyrophosphatase	24	3
Voltage-gated potassium channels	EF-hand	24	4
Galactose-binding domain-like	Galactose-binding domain-like	24	3
F-box domain	RNI-like	24	2
	Regulatory factor Nef	24	2
beta-beta-alpha zinc fingers	Leucine zipper domain	24	3
delta-Endotoxin (insectocide), N-terminal domain	delta-Endotoxin (insectocide), middle domain	24	3
MHC antigen-recognition domain	Immunoglobulin	24	1
FabD/lysophospholipase-like	Ribulose-phoshate binding barrel	24	2
	Cobalamin (vitamin B12)-binding domain	24	1
Tricorn protease domain 2	ClpP/crotonase	24	1
Tricorn protease domain 2	PDZ domain-like	24	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	24	2
Sialidases	Galactose-binding domain-like	24	4
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	24	4
	Metallo-hydrolase/oxidoreductase	24	3
Tricorn protease N-terminal domain	Tricorn protease domain 2	24	1
Ribulose-phoshate binding barrel	NAD(P)-binding Rossmann-fold domains	24	2
Ribulose-phoshate binding barrel	Thiolase-like	24	2
Tricorn protease N-terminal domain	ClpP/crotonase	24	1
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	24	7
delta-Endotoxin (insectocide), middle domain	Galactose-binding domain-like	24	3
Formylmethanofuran:tetrahydromethanopterin formyltransferase	Formylmethanofuran:tetrahydromethanopterin formyltransferase	24	1
Tricorn protease N-terminal domain	PDZ domain-like	24	1
	TIMP-like	23	3
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	23	6
PR-1-like	Crisp domain-like	23	1
vWA-like	Trypsin-like serine proteases	23	2
RNA-binding domain, RBD	L domain-like	23	2
Hemopexin-like domain	Hemopexin-like domain	23	2
	Alpha-macroglobulin receptor domain	23	3
Anaphylotoxins (complement system)	Alpha-macroglobulin receptor domain	23	3
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	23	2
	WD40 repeat-like	23	4
Riboflavin synthase domain-like	Riboflavin synthase domain-like	23	1
Penicillin-binding protein 2x (pbp-2x), c-terminal domain	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	23	2
gp5 N-terminal domain-like	Phage fibre proteins	23	2
Anaphylotoxins (complement system)	TIMP-like	23	3
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	23	1
Acylphosphatase/BLUF domain-like	Nucleotide cyclase	23	1
LeuD/IlvD-like	Aconitase iron-sulfur domain	23	2
Ankyrin repeat	Ankyrin repeat	23	6
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	22	2
Voltage-gated potassium channels	cAMP-binding domain-like	22	1
	NagB/RpiA/CoA transferase-like	22	2
UBC-like	Cysteine proteinases	22	1
	Head and neck region of the ectodomain of NDV fusion glycoprotein	22	5
FKBP-like	FKBP-like	22	5
Periplasmic binding protein-like II	E6 C-terminal domain-like	22	2
FAD-binding/transporter-associated domain-like	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	22	3
Trimerization domain of TRAF	TRAF domain-like	22	1
Carbamate kinase-like	Acyl-CoA N-acyltransferases (Nat)	22	1
alpha-D-mannose-specific plant lectins	alpha-D-mannose-specific plant lectins	22	3
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	22	1
	beta-lactamase/transpeptidase-like	22	4
S-adenosyl-L-methionine-dependent methyltransferases	DNA methylase specificity domain	22	1
Chaperone J-domain	Thioredoxin-like	22	3
	Class II aaRS ABD-related	22	2
STAT	p53-like transcription factors	22	2
p53-like transcription factors	SH2 domain	22	2
4Fe-4S ferredoxins	Fe-only hydrogenase	22	2
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	22	1
Arp2/3 complex subunits	Arp2/3 complex subunits	22	1
L30e-like	alpha/beta knot	22	1
BAH domain	S-adenosyl-L-methionine-dependent methyltransferases	22	4
STAT	SH2 domain	22	2
YjeF N-terminal domain-like	Ribokinase-like	22	1
Periplasmic binding protein-like II	RING/U-box	22	1
Non-globular alpha+beta subunits of globular proteins	ISP transmembrane anchor	22	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	22	2
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	22	3
Fibronectin type III	Protein kinase-like (PK-like)	22	3
EGF/Laminin	Calcium-dependent phosphotriesterase	22	6
FYVE/PHD zinc finger	Clavaminate synthase-like	22	3
Non-globular alpha+beta subunits of globular proteins	ISP domain	22	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	21	4
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	21	4
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	21	3
Snake toxin-like	Snake toxin-like	21	2
BAR/IMD domain-like	PH domain-like	21	1
Galactose-binding domain-like	Agglutinin HPA-like	21	1
NAD(P)-binding Rossmann-fold domains	4'-phosphopantetheinyl transferase	21	1
vWA-like	Integrin alpha N-terminal domain	21	3
ARM repeat	Clathrin adaptor appendage domain	21	1
FabD/lysophospholipase-like	4'-phosphopantetheinyl transferase	21	1
	PDZ domain-like	21	2
Putative DNA-binding domain	Probable bacterial effector-binding domain	21	1
	Mob1/phocein	21	1
Nudix	Phosphoglycerate mutase-like	21	2
Head and neck region of the ectodomain of NDV fusion glycoprotein	Leucine zipper domain	21	3
MurE/MurF N-terminal domain	Trimeric LpxA-like enzymes	21	1
Thiolase-like	4'-phosphopantetheinyl transferase	21	1
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	21	4
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	21	3
PYP-like sensor domain (PAS domain)	C-terminal effector domain of the bipartite response regulators	21	1
Sialidases	Phage fibre proteins	21	1
Rotavirus NSP2 fragment, N-terminal domain	Rotavirus NSP2 fragment, C-terminal domain	21	1
RING/U-box	Cysteine proteinases	21	4
Plexin repeat	E set domains	21	4
beta-N-acetylhexosaminidase-like domain	Hyaluronidase post-catalytic domain-like	21	2
ARM repeat	Subdomain of clathrin and coatomer appendage domain	21	1
TPR-like	Fic-like	20	1
Retrovirus capsid protein, N-terminal core domain	Retrovirus zinc finger-like domains	20	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	20	2
Actin-crosslinking proteins	Actin-crosslinking proteins	20	1
Nucleotide-diphospho-sugar transferases	UDP-Glycosyltransferase/glycogen phosphorylase	20	1
Chemotaxis receptor methyltransferase CheR, N-terminal domain	S-adenosyl-L-methionine-dependent methyltransferases	20	1
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	20	2
ACT-like	Formyltransferase	20	1
Myosin rod fragments	Myosin rod fragments	20	6
LysM domain	LysM domain	20	7
	Leucine zipper domain	20	3
	Head and neck region of the ectodomain of NDV fusion glycoprotein	20	2
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	20	4
Nucleotide-binding domain	4Fe-4S ferredoxins	20	1
	Acyl-CoA dehydrogenase C-terminal domain-like	20	2
EF-hand	Inorganic pyrophosphatase	20	8
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	20	1
alpha-helical ferredoxin	4Fe-4S ferredoxins	20	1
FMN-linked oxidoreductases	4Fe-4S ferredoxins	20	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	20	2
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	20	1
Dom34/Pelota N-terminal domain-like	L30e-like	20	1
	Translin	20	1
Ubiquitin-like	FKBP-like	20	1
Urease, gamma-subunit	Urease, beta-subunit	20	2
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	20	1
Galactose oxidase, central domain	E set domains	20	3
	TPR-like	20	4
alpha-helical ferredoxin	FMN-linked oxidoreductases	20	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	20	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	S13-like H2TH domain	20	2
Quinoprotein alcohol dehydrogenase-like	Calcium-dependent phosphotriesterase	20	3
FAD/NAD(P)-binding domain	Folate-binding domain	20	2
TolB, N-terminal domain	Tricorn protease N-terminal domain	20	1
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	20	1
	Acyl-CoA dehydrogenase NM domain-like	20	2
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	20	2
Retrovirus capsid dimerization domain-like	Retrovirus zinc finger-like domains	20	2
Dom34/Pelota N-terminal domain-like	Translational machinery components	20	1
	Nucleotide-diphospho-sugar transferases	20	2
Nucleic acid-binding proteins	eIF2alpha middle domain-like	20	2
S13-like H2TH domain	Ribosomal protein S5 domain 2-like	20	2
	PUA domain-like	19	2
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	19	3
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	19	1
Glycoside hydrolase/deacetylase	Carbohydrate binding domain	19	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	19	2
Nucleotidylyl transferase	Alpha-L RNA-binding motif	19	1
SAM/Pointed domain	SAM/Pointed domain	19	9
Zn2/Cys6 DNA-binding domain	Leucine zipper domain	19	1
Virus ectodomain	Fibritin	19	3
Barwin-like endoglucanases	PHL pollen allergen	19	1
Rubredoxin-like	Superoxide reductase-like	19	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	19	2
Dcp2 domain-like	Nudix	19	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	19	1
tRNA-intron endonuclease catalytic domain-like	tRNA-intron endonuclease catalytic domain-like	19	2
Carbohydrate binding domain	Carbohydrate binding domain	19	1
Orange carotenoid protein, N-terminal domain	NTF2-like	19	1
Leukocidin-like	Ricin B-like lectins	19	2
MgtE N-terminal domain-like	CBS-domain pair	19	1
Restriction endonuclease-like	P-loop containing nucleoside triphosphate hydrolases	19	4
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	19	2
Sema domain	E set domains	19	3
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	19	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	19	1
	FAD-dependent thiol oxidase	19	4
Cytochrome b5-like heme/steroid binding domain	FMN-linked oxidoreductases	18	1
PH0987 N-terminal domain-like	Cyclophilin-like	18	4
LigB-like	LigA subunit of an aromatic-ring-opening dioxygenase LigAB	18	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	18	4
Periplasmic binding protein-like II	Suppressor of Fused, N-terminal domain	18	1
	GTPase activation domain, GAP	18	3
Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	18	2
Ubiquitin-like	GTPase activation domain, GAP	18	3
2Fe-2S ferredoxin-like	Fe-only hydrogenase	18	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	18	2
Nucleotidylyl transferase	Nucleotidylyl transferase	18	2
EspE N-terminal domain-like	EspE N-terminal domain-like	18	1
ADP-ribosylation	Diphtheria toxin, middle domain	18	1
PurM N-terminal domain-like	PurM N-terminal domain-like	18	3
PYP-like sensor domain (PAS domain)	PH domain-like	18	3
Putative DNA-binding domain	Cobalamin (vitamin B12)-binding domain	18	1
PX domain	BAR/IMD domain-like	18	3
	Metalloproteases ("zincins"), catalytic domain	18	2
FMN-linked oxidoreductases	Ribulose-phoshate binding barrel	18	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	18	1
ADP-ribosylation	Diphtheria toxin, C-terminal domain	18	1
PurM C-terminal domain-like	PurM C-terminal domain-like	18	3
Coronavirus S2 glycoprotein	Leucine zipper domain	18	2
Creatinase/aminopeptidase	Creatinase/aminopeptidase	18	3
Diphtheria toxin, middle domain	Diphtheria toxin, C-terminal domain	18	1
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	18	2
	BAR/IMD domain-like	18	3
DEATH domain	"Winged helix" DNA-binding domain	18	1
Immunoglobulin-binding domains	DEATH domain	18	3
C-type lectin-like	EGF/Laminin	18	3
CheY-like	KaiA/RbsU domain	18	1
Adhesin YadA, collagen-binding domain	Adhesin YadA, collagen-binding domain	18	4
p53-like transcription factors	p53 tetramerization domain	18	1
Phospholipase C/P1 nuclease	Lipase/lipooxygenase domain (PLAT/LH2 domain)	18	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	18	2
Collagen-binding domain	Collagen-binding domain	18	7
Second domain of FERM	SH2 domain	18	4
"Winged helix" DNA-binding domain	Actin-like ATPase domain	18	2
Resolvase-like	Homeodomain-like	18	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	18	1
	BRCT domain	18	4
PH domain-like	SH2 domain	18	4
	(Phosphotyrosine protein) phosphatases II	18	2
Cysteine proteinases	Glutathione synthetase ATP-binding domain-like	17	1
Prokaryotic type KH domain (KH-domain type II)	Metallo-hydrolase/oxidoreductase	17	4
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	17	2
Ricin B-like lectins	C-type lectin-like	17	2
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	17	3
alpha/beta-Hydrolases	beta-Roll	17	1
Ubiquitin-like	GTPase activation domain, GAP	17	1
Pre-PUA domain	PUA domain-like	17	3
Kringle-like	C-type lectin-like	17	2
N-utilization substance G protein NusG, N-terminal domain	N-utilization substance G protein NusG, N-terminal domain	17	5
Isocitrate/Isopropylmalate dehydrogenase-like	Isocitrate/Isopropylmalate dehydrogenase-like	17	3
4Fe-4S ferredoxins	ADC-like	17	1
	Multiheme cytochromes	17	2
Thioredoxin-like	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	17	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease N-terminal domain-like	17	1
beta-Roll	beta-Roll	17	1
2Fe-2S ferredoxin-like	ADC-like	17	1
DnaK suppressor protein DksA, alpha-hairpin domain	Glucocorticoid receptor-like (DNA-binding domain)	17	1
	S-adenosyl-L-methionine-dependent methyltransferases	17	4
Chaperone J-domain	Thioredoxin-like	17	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	17	3
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	17	4
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	17	2
(Trans)glycosidases	Invasin/intimin cell-adhesion fragments	17	4
Cell wall binding repeat	Cell wall binding repeat	17	3
	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	17	2
	SMAD/FHA domain	17	2
Galactose-binding domain-like	Fibronectin type III	17	4
Ricin B-like lectins	Kringle-like	17	2
Pectin lyase-like	Pectin lyase-like	17	2
"Winged helix" DNA-binding domain	Phospholipase D/nuclease	17	2
MgtE N-terminal domain-like	CBS-domain pair	17	2
SNARE-like	SNARE fusion complex	17	1
Bacterial muramidases	Lysozyme-like	17	1
TMV-like viral coat proteins	TMV-like viral coat proteins	17	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	17	2
Cysteine proteinases	PreATP-grasp domain	17	1
PH domain-like	PH domain-like	17	4
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	17	5
	Glycosyl hydrolases family 6, cellulases	17	1
	Metallo-dependent hydrolases	16	2
dsRNA-binding domain-like	dsRNA-binding domain-like	16	6
EGF/Laminin	Kringle-like	16	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	16	1
LysM domain	L,D-transpeptidase catalytic domain-like	16	1
Ankyrin repeat	Bacterial immunoglobulin/albumin-binding domains	16	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	16	1
MOP-like	MOP-like	16	2
	Actin-like ATPase domain	16	4
Trigger factor ribosome-binding domain	FKBP-like	16	1
DEATH domain	Caspase-like	16	1
	Carbon-nitrogen hydrolase	16	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	16	3
Growth factor receptor domain	Fibronectin type III	16	4
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	16	3
Periplasmic binding protein-like II	Bcl-2 inhibitors of programmed cell death	16	1
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	16	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	16	2
TPR-like	UDP-Glycosyltransferase/glycogen phosphorylase	16	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	16	1
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	16	6
N-acetylmuramoyl-L-alanine amidase-like	PGBD-like	16	1
	Ribosome inactivating proteins (RIP)	16	3
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	16	3
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Bacterial immunoglobulin/albumin-binding domains	16	1
Periplasmic binding protein-like II	P-loop containing nucleoside triphosphate hydrolases	16	1
BAH domain	BAH domain	16	3
	Duffy binding domain-like	16	6
	Tudor/PWWP/MBT	16	2
	LeuD/IlvD-like	16	2
Saposin	Metallo-dependent phosphatases	15	2
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	15	1
Ubiquitin-like	Moesin tail domain	15	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	15	5
RuvA domain 2-like	RuvA domain 2-like	15	6
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	15	1
	Head and neck region of the ectodomain of NDV fusion glycoprotein	15	2
Elongation factor Ts (EF-Ts), dimerisation domain	P-loop containing nucleoside triphosphate hydrolases	15	2
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	15	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	15	1
beta-lactamase/transpeptidase-like	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	15	1
Nudix	"Winged helix" DNA-binding domain	15	1
	Acyl-CoA dehydrogenase C-terminal domain-like	15	2
EPT/RTPC-like	EPT/RTPC-like	15	1
UBA-like	P-loop containing nucleoside triphosphate hydrolases	15	2
UBA-like	Translation proteins	15	2
SH3-domain	SH3-domain	15	7
	DNA/RNA polymerases	15	2
	Second domain of FERM	15	3
RecA protein, C-terminal domain	RecA protein, C-terminal domain	15	3
	PH0987 N-terminal domain-like	15	3
P-loop containing nucleoside triphosphate hydrolases	Hcp1-like	15	1
Cytochrome f, large domain	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	15	2
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	15	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	15	1
UBA-like	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	15	2
Invasin/intimin cell-adhesion fragments	C-type lectin-like	15	3
Elongation factor Ts (EF-Ts), dimerisation domain	Translation proteins	15	2
Penicillin binding protein dimerisation domain	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	15	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	15	1
	Zn-dependent exopeptidases	15	1
Restriction endonuclease-like	Rad51 N-terminal domain-like	15	2
FKBP-like	TPR-like	15	2
alpha/beta-Hydrolases	alpha/beta-Hydrolases	15	2
RING/U-box	TRAF domain-like	15	1
Cupredoxins	Cytochrome c	15	3
Leukocidin-like	Ricin B-like lectins	15	1
Elongation factor Ts (EF-Ts), dimerisation domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	15	2
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	15	1
Phage tail proteins	gp5 N-terminal domain-like	15	2
Alpha-L RNA-binding motif	Pseudouridine synthase	15	1
	Glycoside hydrolase/deacetylase	15	1
Thioredoxin-like	FAD-dependent thiol oxidase	15	3
	HD-domain/PDEase-like	15	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	15	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	15	1
Clavaminate synthase-like	Clavaminate synthase-like	15	4
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	15	5
DNA-binding protein LAG-1 (CSL)	E set domains	15	1
Rudiment single hybrid motif	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	15	2
Sec7 domain	PH domain-like	14	3
Class I glutamine amidotransferase-like	Glycosyl hydrolase domain	14	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	14	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	14	1
Alanine racemase C-terminal domain-like	Alanine racemase C-terminal domain-like	14	1
	PRTase-like	14	1
Leucine zipper domain	Head morphogenesis protein gp7	14	3
SAP domain	Ribonuclease H-like	14	3
Metallo-hydrolase/oxidoreductase	Rhodanese/Cell cycle control phosphatase	14	2
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	14	1
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	Rhodanese/Cell cycle control phosphatase	14	2
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	14	2
PMT central region-like	EreA/ChaN-like	14	2
	DNA repair protein MutS, domain III	14	2
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	14	2
Metalloproteases ("zincins"), catalytic domain	Adenylylcyclase toxin (the edema factor)	14	3
Phage tail proteins	Phage fibre proteins	14	1
RNase III domain-like	RNase III domain-like	14	4
Carbamate kinase-like	PUA domain-like	14	1
P-loop containing nucleoside triphosphate hydrolases	Cobalamin (vitamin B12)-dependent enzymes	14	1
MalF N-terminal region-like	MetI-like	14	1
YojJ-like	RuvA domain 2-like	14	1
Kringle-like	Trypsin-like serine proteases	14	4
	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	14	3
SMAD/FHA domain	Protein kinase-like (PK-like)	14	2
Cobalamin (vitamin B12)-binding domain	P-loop containing nucleoside triphosphate hydrolases	14	1
Lysozyme-like	PH domain-like	14	3
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	14	6
Bromodomain	Bromodomain	14	6
Lysozyme-like	Cytochromes	14	2
P-loop containing nucleoside triphosphate hydrolases	ACT-like	14	1
	Lysozyme-like	14	5
	Amidase signature (AS) enzymes	14	2
FAD/NAD(P)-binding domain	Rhodanese/Cell cycle control phosphatase	14	2
L domain-like	NTF2-like	14	3
Hedgehog/intein (Hint) domain	Homing endonucleases	14	4
	Trimeric LpxA-like enzymes	14	1
Actin-like ATPase domain	Protein kinase-like (PK-like)	14	2
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	14	3
Rap30/74 interaction domains	Rap30/74 interaction domains	13	2
NHL repeat	YVTN repeat-like/Quinoprotein amine dehydrogenase	13	2
Globin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	13	1
Nucleic acid-binding proteins	Prokaryotic type KH domain (KH-domain type II)	13	4
ACP-like	Thiolase-like	13	3
	Cytochrome P450	13	1
N-utilization substance G protein NusG, N-terminal domain	N-utilization substance G protein NusG, N-terminal domain	13	3
PK beta-barrel domain-like	Phosphohistidine domain	13	2
S15/NS1 RNA-binding domain	Nucleotidylyl transferase	13	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	13	1
Cloroperoxidase	Cloroperoxidase	13	1
N-terminal domain of bifunctional PutA protein	ALDH-like	13	2
Globin-like	Riboflavin synthase domain-like	13	1
E set domains	Terpenoid cyclases/Protein prenyltransferases	13	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	13	2
Adenine nucleotide alpha hydrolases-like	MesJ substrate recognition domain-like	13	2
Notch domain	Notch domain	13	1
Formyltransferase	Ankyrin repeat	13	1
PK C-terminal domain-like	Phosphohistidine domain	13	2
Complement control module/SCR domain	vWA-like	13	1
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	13	2
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	13	1
ACP-like	alpha/beta-Hydrolases	13	3
Protein kinase-like (PK-like)	NTF2-like	13	1
ENTH/VHS domain	GAT-like domain	13	2
Galactose-binding domain-like	Galactose oxidase, central domain	13	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	13	3
P-loop containing nucleoside triphosphate hydrolases	TrpR-like	13	2
Translation proteins	ThrRS/AlaRS common domain	13	5
(Trans)glycosidases	Beta-galactosidase LacA, domain 3	13	1
Tudor/PWWP/MBT	Staphylococcal nuclease	13	3
Ankyrin repeat	beta-lactamase/transpeptidase-like	13	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	13	2
Beta-galactosidase LacA, domain 3	Galactose-binding domain-like	13	1
Ricin B-like lectins	Hemolytic lectin CEL-III, C-terminal domain	13	1
Growth factor receptor domain	TNF receptor-like	13	4
(Trans)glycosidases	Anthrax protective antigen	13	2
FMN-linked oxidoreductases	FAD/NAD(P)-binding domain	13	2
ArfGap/RecO-like zinc finger	Ankyrin repeat	13	3
E set domains	alpha/beta-Hydrolases	13	1
Plexin repeat	Plexin repeat	13	1
Glycosyl hydrolase domain	Beta-galactosidase LacA, domain 3	13	1
Ricin B-like lectins	Cysteine proteinases	13	1
FMT C-terminal domain-like	Ankyrin repeat	13	1
beta-lactamase/transpeptidase-like	SpoIIaa-like	13	1
	Homeodomain-like	13	3
Outer surface protein	Outer surface protein	13	3
Tudor/PWWP/MBT	FYVE/PHD zinc finger	13	2
CBD9-like	PHM/PNGase F	13	1
Bacteriophage trimeric proteins domain	C-type lectin-like	13	1
Formyltransferase	Acetyl-CoA synthetase-like	12	2
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	12	1
GAF domain-like	Nucleotide cyclase	12	2
	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	12	4
	Class II aaRS and biotin synthetases	12	2
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	12	1
FAD-linked reductases, C-terminal domain	Folate-binding domain	12	1
HD-domain/PDEase-like	Nucleotidyltransferase	12	2
B-box zinc-binding domain	tRNA-binding arm	12	1
Class I glutamine amidotransferase-like	Class I glutamine amidotransferase-like	12	1
	tRNA-binding arm	12	1
	Immunoglobulin-binding domains	12	1
"Winged helix" DNA-binding domain	PLP-dependent transferases	12	1
PIN domain-like	Nucleic acid-binding proteins	12	3
Homeodomain-like	mu transposase, C-terminal domain	12	2
Dextranase, N-terminal domain	Pectin lyase-like	12	1
Lysozyme-like	E set domains	12	1
	Carbohydrate phosphatase	12	1
Fibronectin type III	Immunoglobulin	12	2
Thioredoxin-like	ERP29 C domain-like	12	1
EV matrix protein	EV matrix protein	12	2
TSP-1 type 1 repeat	TSP-1 type 1 repeat	12	6
	FAH	12	1
Formyltransferase	NAD(P)-binding Rossmann-fold domains	12	1
Glutaminase/Asparaginase	Ankyrin repeat	12	1
	FabD/lysophospholipase-like	12	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	12	1
PLP-dependent transferases	PLP-dependent transferases	12	2
Molybdenum cofactor biosynthesis proteins	CinA-like	12	1
FMN-linked oxidoreductases	FMN-linked oxidoreductases	12	1
	Cysteine proteinases	12	4
Hedgehog/intein (Hint) domain	Hedgehog/intein (Hint) domain	12	1
Voltage-gated potassium channels	Small-conductance potassium channel	12	1
	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	12	2
L9 N-domain-like	EF-G C-terminal domain-like	12	2
Family A G protein-coupled receptor-like	E set domains	12	1
L9 N-domain-like	Translation proteins	12	2
	Methyl-coenzyme M reductase alpha and beta chain C-terminal domain	12	1
Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	12	1
Cobalamin adenosyltransferase-like	Ankyrin repeat	12	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	12	1
Cytidine deaminase-like	Cytidine deaminase-like	12	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	12	1
PH domain-like	(Phosphotyrosine protein) phosphatases II	12	3
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	12	5
Immunoglobulin-binding domains	gp120 core	12	1
beta-N-acetylhexosaminidase-like domain	Ricin B-like lectins	12	1
FMT C-terminal domain-like	NAD(P)-binding Rossmann-fold domains	12	1
Trimeric LpxA-like enzymes	RmlC-like cupins	12	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	12	3
"Winged helix" DNA-binding domain	LexA/Signal peptidase	12	1
	ADC synthase	12	1
C-type lectin-like	Bacterial enterotoxins	12	1
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain	Phosphoenolpyruvate/pyruvate domain	12	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	12	4
SH3-domain	Ankyrin repeat	12	2
Leucine zipper domain	Virus attachment protein globular domain	12	2
ARM repeat	WD40 repeat-like	12	4
ParB/Sulfiredoxin	KorB DNA-binding domain-like	12	1
L9 N-domain-like	P-loop containing nucleoside triphosphate hydrolases	12	2
GLA-domain	Kringle-like	12	2
Clc chloride channel	CBS-domain pair	12	2
CheY-like	P-loop containing nucleoside triphosphate hydrolases	12	2
	UBA-like	11	5
Topoisomerase V catalytic domain-like	RuvA domain 2-like	11	4
PAZ domain	RNase III domain-like	11	2
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	11	1
	PGBD-like	11	1
	PH domain-like	11	1
L domain-like	Fibronectin type III	11	3
Putative DNA-binding domain	Class II aaRS and biotin synthetases	11	1
Nucleotidyltransferase	Retrovirus zinc finger-like domains	11	2
Cu,Zn superoxide dismutase-like	Cu,Zn superoxide dismutase-like	11	2
4Fe-4S ferredoxins	4Fe-4S ferredoxins	11	1
PAP/OAS1 substrate-binding domain	Retrovirus zinc finger-like domains	11	2
Translation proteins	DNA/RNA polymerases	11	1
CCCH zinc finger	RNA-binding domain, RBD	11	3
PH domain-like	EF-hand	11	4
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	11	1
vWA-like	TSP-1 type 1 repeat	11	2
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	11	2
	Duffy binding domain-like	11	2
F-box domain	WD40 repeat-like	11	1
ACP-like	CoA-dependent acyltransferases	11	4
PH domain-like	PLC-like phosphodiesterases	11	4
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	11	2
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	11	2
YegP-like	YegP-like	11	7
Nucleotide cyclase	EAL domain-like	11	3
SH2 domain	SOCS box-like	11	1
Histone-fold	Histone-fold	11	2
UBA-like	DNA/RNA polymerases	11	1
	ThrRS/AlaRS common domain	11	3
	ThrRS/AlaRS common domain	11	2
	S-adenosyl-L-methionine-dependent methyltransferases	11	3
Sialidases	Galactose-binding domain-like	11	1
Head morphogenesis protein gp7	EB1 dimerisation domain-like	11	2
UBC-like	UBA-like	11	3
Fucose-specific lectin	Fucose-specific lectin	11	1
PHP domain-like	AF1531-like	11	2
Sialidases	E set domains	11	1
Periplasmic binding protein-like II	Cytidine deaminase-like	11	1
	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	11	3
Concanavalin A-like lectins/glucanases	EGF/Laminin	11	5
Ankyrin repeat	Protein kinase-like (PK-like)	11	2
NAD(P)-binding Rossmann-fold domains	Siroheme synthase middle domains-like	11	2
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	DNA/RNA polymerases	11	1
Elongation factor Ts (EF-Ts), dimerisation domain	DNA/RNA polymerases	11	1
	Retrovirus zinc finger-like domains	11	2
CheY-like	CheY-like	11	2
ClpP/crotonase	PGBD-like	11	1
Carboxypeptidase regulatory domain-like	Type I dockerin domain	11	2
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	11	1
Sec-C motif	Sec-C motif	11	1
Invasin/intimin cell-adhesion fragments	Invasin/intimin cell-adhesion fragments	11	6
PDZ domain-like	PGBD-like	11	1
Class II aaRS and biotin synthetases	Translation proteins	10	3
Aldolase	AFP III-like domain	10	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	10	1
BAR/IMD domain-like	BAR/IMD domain-like	10	2
	beta-lactamase/transpeptidase-like	10	4
	FKBP-like	10	4
Mitochondrial carrier	Mitochondrial carrier	10	1
YrdC/RibB	Actin-like ATPase domain	10	2
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	10	1
Tropomyosin	EB1 dimerisation domain-like	10	2
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	10	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	10	1
Transcription factor NusA, N-terminal domain	Nucleic acid-binding proteins	10	3
	Alanine racemase C-terminal domain-like	10	3
	Bcl-2 inhibitors of programmed cell death	10	1
GFP-like	Bcl-2 inhibitors of programmed cell death	10	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	10	3
TGS-like	ThrRS/AlaRS common domain	10	3
	Enolase C-terminal domain-like	10	1
4Fe-4S ferredoxins	ARM repeat	10	1
WW domain	Hect, E3 ligase catalytic domain	10	3
TPR-like	Metallo-dependent phosphatases	10	1
Periplasmic binding protein-like II	Pili subunits	10	1
L9 N-domain-like	Ribosomal protein S5 domain 2-like	10	1
EF-hand	Inorganic pyrophosphatase	10	2
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type I DNA topoisomerase	10	1
Insect pheromone/odorant-binding proteins	Insect pheromone/odorant-binding proteins	10	2
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	10	2
dUTPase-like	dUTPase-like	10	2
GLA-domain	Trypsin-like serine proteases	10	2
	Duffy binding domain-like	10	3
His-Me finger endonucleases	Recombination endonuclease VII, C-terminal and dimerization domains	10	1
vWA-like	Cysteine-rich domain	10	1
Acylphosphatase/BLUF domain-like	EAL domain-like	10	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	10	3
N-utilization substance G protein NusG, insert domain	Translation proteins SH3-like domain	10	1
Acylphosphatase/BLUF domain-like	Actin-like ATPase domain	10	2
P-loop containing nucleoside triphosphate hydrolases	PLP-dependent transferases	10	1
Complement control module/SCR domain	vWA-like	10	1
N-utilization substance G protein NusG, insert domain	N-utilization substance G protein NusG, N-terminal domain	10	1
Gated mechanosensitive channel	Lumazine synthase	10	1
DNA-glycosylase	Nudix	10	1
Putative glucosidase YicI, C-terminal domain	Galactose-binding domain-like	10	1
	FabD/lysophospholipase-like	10	3
	RNA-binding domain, RBD	10	1
(Trans)glycosidases	Acyl-CoA N-acyltransferases (Nat)	10	2
Acylphosphatase/BLUF domain-like	YrdC/RibB	10	2
DNA-binding domain	DNA breaking-rejoining enzymes	10	1
DEATH domain	RNI-like	10	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	10	1
Prokaryotic SH3-related domain	Cysteine proteinases	10	1
C2 domain (Calcium/lipid-binding domain, CaLB)	FabD/lysophospholipase-like	10	2
	Thiolase-like	10	3
PGBD-like	Lysozyme-like	10	1
Acyl-CoA N-acyltransferases (Nat)	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	10	1
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	10	2
FYSH domain	EF-G C-terminal domain-like	10	1
EF-hand	P-loop containing nucleoside triphosphate hydrolases	10	2
Hypothetical protein AF0491, middle domain	EF-G C-terminal domain-like	10	1
PDZ domain-like	SH3-domain	10	2
Transcription factor NusA, N-terminal domain	Prokaryotic type KH domain (KH-domain type II)	10	3
Hermes dimerisation domain	Ribonuclease H-like	10	1
Myosin rod fragments	Leucine zipper domain	10	1
FAD-linked reductases, C-terminal domain	Thioredoxin-like	10	1
Bacterial adhesins	Bacterial adhesins	10	3
	Probable ACP-binding domain of malonyl-CoA ACP transacylase	10	3
	Single hybrid motif	10	2
E set domains	NHL repeat	10	4
Ribonuclease H-like	RuvA domain 2-like	10	5
	HSP90 C-terminal domain	10	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	10	1
post-HMGL domain-like	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	10	1
FYSH domain	Hypothetical protein AF0491, middle domain	10	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	10	1
Chitinase insertion domain	Invertebrate chitin-binding proteins	9	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	9	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	9	2
Bacterial immunoglobulin/albumin-binding domains	EF-hand	9	1
UBC-like	Cysteine proteinases	9	1
Nudix	Nudix	9	2
PurS-like	PurM C-terminal domain-like	9	3
Lysozyme-like	Phage fibre proteins	9	1
	PLP-dependent transferases	9	1
Globin-like	Globin-like	9	1
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	9	2
GAF domain-like	HD-domain/PDEase-like	9	3
GST C-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	9	2
PLP-dependent transferases	Bacterial immunoglobulin/albumin-binding domains	9	1
DNA methylase specificity domain	DNA methylase specificity domain	9	2
	Pectin lyase-like	9	3
Trypsin-like serine proteases	PDZ domain-like	9	1
Fibritin	Fibritin	9	1
Fibre shaft of virus attachment proteins	Fibritin	9	1
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	9	1
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	9	4
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	9	2
	Alpha-macroglobulin receptor domain	9	2
Nucleic acid-binding proteins	ArfGap/RecO-like zinc finger	9	1
Periplasmic binding protein-like II	ACT-like	9	2
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	9	1
RCC1/BLIP-II	CSL zinc finger	9	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	9	2
beta-Galactosidase/glucuronidase domain	Invasin/intimin cell-adhesion fragments	9	3
SAM/Pointed domain	HD-domain/PDEase-like	9	2
THUMP domain-like	Adenine nucleotide alpha hydrolases-like	9	1
(Trans)glycosidases	Invertebrate chitin-binding proteins	9	1
BPTI-like	BPTI-like	9	3
FAD/NAD(P)-binding domain	HI0933 insert domain-like	9	1
	Invasin/intimin cell-adhesion fragments	9	3
GroEL-intermediate domain like	GroEL apical domain-like	9	2
Peridinin-chlorophyll protein	Peridinin-chlorophyll protein	9	3
	CSL zinc finger	9	1
Nucleotide-diphospho-sugar transferases	Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain	9	1
Uteroglobin-like	Uteroglobin-like	9	1
HCP-like	HCP-like	9	3
gp5 N-terminal domain-like	Lysozyme-like	9	1
Duffy binding domain-like	Duffy binding domain-like	9	3
BAH domain	FYVE/PHD zinc finger	9	2
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	9	2
Leucine zipper domain	Fibre shaft of virus attachment proteins	9	1
Cullin repeat-like	Cullin homology domain	9	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	9	4
ACT-like	HAD-like	9	1
Cullin repeat-like	"Winged helix" DNA-binding domain	9	1
Periplasmic binding protein-like II	LexA/Signal peptidase	9	2
	all-alpha NTP pyrophosphatases	9	1
Periplasmic binding protein-like II	Nuclear receptor ligand-binding domain	9	1
	OmpA-like	9	1
	ValRS/IleRS/LeuRS editing domain	9	2
RNA-binding domain, RBD	Ran binding protein zinc finger-like	9	1
Colipase-like	Colipase-like	9	1
Caspase-like	E set domains	9	2
Galactose-binding domain-like	Invasin/intimin cell-adhesion fragments	9	3
ARM repeat	"Winged helix" DNA-binding domain	9	1
CheY-like	Nucleotide cyclase	9	2
P-loop containing nucleoside triphosphate hydrolases	Probable GTPase Der, C-terminal domain	9	2
Lysozyme-like	Cysteine proteinases	8	1
Thioredoxin-like	RNA-binding domain, RBD	8	1
Homing endonucleases	YcfA/nrd intein domain	8	4
Pentapeptide repeat-like	Pentapeptide repeat-like	8	2
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	8	2
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	8	1
Ubiquitin-like	Ras GEF	8	2
Calpain large subunit, middle domain (domain III)	EF-hand	8	2
C-terminal, gelsolin-like domain of Sec23/24	Actin depolymerizing proteins	8	1
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	8	2
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	8	2
PurS-like	PurM C-terminal domain-like	8	1
MIR domain	ARM repeat	8	1
WGR domain-like	Domain of poly(ADP-ribose) polymerase	8	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	8	2
WW domain	WW domain	8	4
	ARM repeat	8	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	8	4
IP3 receptor type 1 binding core, domain 2	ARM repeat	8	1
Trypsin-like serine proteases	Trypsin-like serine proteases	8	1
Head-binding domain of phage P22 tailspike protein	Leucine zipper domain	8	1
Periplasmic binding protein-like II	E6 C-terminal domain-like	8	3
	Enzyme IIa from lactose specific PTS, IIa-lac	8	1
Bromodomain	Tudor/PWWP/MBT	8	3
Actin-like ATPase domain	HD-domain/PDEase-like	8	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	8	2
HprK N-terminal domain-like	PEP carboxykinase-like	8	1
GST C-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	8	1
Concanavalin A-like lectins/glucanases	EF-hand	8	1
P-loop containing nucleoside triphosphate hydrolases	Sec-C motif	8	1
PIN domain-like	Nucleic acid-binding proteins	8	1
	"Helical backbone" metal receptor	8	1
Restriction endonuclease-like	RuvA domain 2-like	8	1
PurS-like	FGAM synthase PurL, linker domain	8	1
"Winged helix" DNA-binding domain	PRTase-like	8	1
	Periplasmic binding protein-like II	8	3
Thioredoxin-like	P-loop containing nucleoside triphosphate hydrolases	8	1
DNA polymerase beta, N-terminal domain-like	Rad51 N-terminal domain-like	8	1
MbtH-like	Acetyl-CoA synthetase-like	8	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	8	2
PurS-like	PurM N-terminal domain-like	8	1
S15/NS1 RNA-binding domain	Ns1 effector domain-like	8	1
Major surface antigen p30, SAG1	Major surface antigen p30, SAG1	8	4
	Acetyl-CoA synthetase-like	8	3
cAMP-binding domain-like	Acyl-CoA N-acyltransferases (Nat)	8	1
Galactose-binding domain-like	Hyaluronate lyase-like, C-terminal domain	8	2
	Supernatant protein factor (SPF), C-terminal domain	8	1
HlyD-like secretion proteins	HlyD-like secretion proteins	8	1
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	8	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	8	2
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	8	1
FAH	FAH	8	1
	SNARE fusion complex	8	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	8	3
tRNA-guanine transglycosylase	Pre-PUA domain	8	1
WD40 repeat-like	DPP6 N-terminal domain-like	8	1
Cloacin translocation domain	Colicin E3 receptor domain	8	2
cAMP-binding domain-like	Ubiquitin-like	8	2
SRCR-like	Trypsin-like serine proteases	8	2
Ribonuclease H-like	RNA-binding domain, RBD	8	3
tRNA-guanine transglycosylase	PUA domain-like	8	1
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	8	1
Sialidases	Galactose-binding domain-like	8	1
WGR domain-like	ADP-ribosylation	8	1
CBS-domain pair	MgtE membrane domain-like	8	1
Rad51 N-terminal domain-like	PHP domain-like	8	1
Galactose-binding domain-like	Six-hairpin glycosidases	8	4
cAMP-binding domain-like	Ras GEF	8	2
Arabinanase/levansucrase/invertase	Galactose-binding domain-like	8	2
Rad51 N-terminal domain-like	Nucleotidyltransferase	8	1
YojJ-like	RuvA domain 2-like	8	1
Cytochrome b5-like heme/steroid binding domain	E set domains	8	1
	Prismane protein-like	8	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheW-like	8	2
Uteroglobin-like	Uteroglobin-like	8	2
"Winged helix" DNA-binding domain	MOP-like	8	1
MgtE N-terminal domain-like	MgtE membrane domain-like	8	1
PGBD-like	Kringle-like	8	3
P-loop containing nucleoside triphosphate hydrolases	Prismane protein-like	8	1
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	Multidrug efflux transporter AcrB transmembrane domain	8	4
DNA polymerase beta, N-terminal domain-like	PHP domain-like	8	1
Triger factor/SurA peptide-binding domain-like	FKBP-like	8	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	8	1
E set domains	E set domains	8	3
Lipocalins	Lipocalins	8	1
PurS-like	Class I glutamine amidotransferase-like	8	1
TPR-like	Clavaminate synthase-like	8	1
SNARE fusion complex	SNARE fusion complex	8	1
Spectrin repeat	Spectrin repeat	8	3
	Prismane protein-like	8	1
DUSP-like	Ubiquitin-like	8	2
S-adenosyl-L-methionine-dependent methyltransferases	NAD(P)-binding Rossmann-fold domains	8	2
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	8	1
Gamma-glutamyl cyclotransferase-like	Gamma-glutamyl cyclotransferase-like	8	4
Cysteine proteinases	EF-hand	8	2
Nucleotidyltransferase	PHP domain-like	8	1
Defensin-like	Defensin-like	8	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	8	1
Beta-D-glucan exohydrolase, C-terminal domain	Anthrax protective antigen	8	1
R3H domain	Ribonuclease H-like	8	2
Metalloproteases ("zincins"), catalytic domain	Kringle-like	8	3
	tRNA-binding arm	8	2
E set domains	Type I dockerin domain	8	3
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	8	1
Cupredoxins	Galactose-binding domain-like	8	4
Hairpin loop containing domain-like	Trypsin-like serine proteases	8	2
Zn-binding domains of ADDBP	Zn-binding domains of ADDBP	7	1
P-loop containing nucleoside triphosphate hydrolases	Spectrin repeat	7	1
	RuvA domain 2-like	7	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	7	1
Galactose-binding domain-like	Ricin B-like lectins	7	2
CheY-like	Homeodomain-like	7	1
Tex N-terminal region-like	Ribonuclease H-like	7	3
Domain of early E2A DNA-binding protein, ADDBP	Zn-binding domains of ADDBP	7	1
Carbohydrate binding domain	Lysozyme-like	7	1
	Cytidine deaminase-like	7	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	7	2
Nudix	NADH pyrophosphatase intervening domain	7	1
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	7	2
CalX-like	CalX-like	7	1
"Winged helix" DNA-binding domain	MukF C-terminal domain-like	7	2
Thermostable phytase (3-phytase)	Thermostable phytase (3-phytase)	7	1
CCCH zinc finger	CCCH zinc finger	7	4
vWA-like	vWA-like	7	2
Restriction endonuclease-like	"Winged helix" DNA-binding domain	7	2
	FAD-linked oxidases, C-terminal domain	7	1
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	7	1
Galactose mutarotase-like	E set domains	7	3
ADC-like	P-loop containing nucleoside triphosphate hydrolases	7	3
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	7	1
FMN-binding split barrel	FMN-binding split barrel	7	1
Sigma3 and sigma4 domains of RNA polymerase sigma factors	CheY-like	7	1
Fibronectin type III	Immunoglobulin	7	2
	EF-G C-terminal domain-like	7	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	7	1
Trefoil	Trefoil	7	1
Subtilisin-like	PA domain	7	3
Nucleotidyltransferase	Nucleotidyltransferase substrate binding subunit/domain	7	2
SH3-domain	DBL homology domain (DH-domain)	7	4
Spermadhesin, CUB domain	Galactose-binding domain-like	7	2
SAM/Pointed domain	ARM repeat	7	1
	Integrin alpha N-terminal domain	7	2
Htr2 transmembrane domain-like	HAMP domain-like	7	1
	HMG-box	7	1
	SET domain	7	1
CoA-dependent acyltransferases	Acetyl-CoA synthetase-like	7	2
Single hybrid motif	CoA-dependent acyltransferases	7	2
Galactose-binding domain-like	EGF/Laminin	7	3
	Intermediate filament protein, coiled coil region	7	1
N-terminal domains of the minor coat protein g3p	N-terminal domains of the minor coat protein g3p	7	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	7	1
NEAT domain-like	NEAT domain-like	7	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	7	4
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	7	1
Cytokine	Cytokine	7	3
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	7	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	7	2
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	7	1
Trypsin-like serine proteases	Pectin lyase-like	7	2
Alpha-lytic protease prodomain	Alpha-lytic protease prodomain	7	1
	DNA helicase RuvA subunit, C-terminal domain	7	1
	Ankyrin repeat	7	2
	DPP6 N-terminal domain-like	7	2
Surp module (SWAP domain)	Surp module (SWAP domain)	7	2
Family A G protein-coupled receptor-like	Rubredoxin-like	7	1
Dihydropteroate synthetase-like	Nitrite and sulphite reductase 4Fe-4S domain-like	7	1
C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	7	1
Kelch motif	Kelch motif	7	1
EGF/Laminin	TB module/8-cys domain	7	1
PUA domain-like	SET domain	7	1
	Phosphoenolpyruvate/pyruvate domain	7	2
Nucleotidylyl transferase	Nudix	7	1
WW domain	Periplasmic binding protein-like II	6	1
Chorismate mutase II	Aldolase	6	1
TGS-like	ACT-like	6	1
Galactose-binding domain-like	Growth factor receptor domain	6	2
2Fe-2S ferredoxin-like	Riboflavin synthase domain-like	6	3
Prokaryotic type KH domain (KH-domain type II)	Metallo-hydrolase/oxidoreductase	6	1
Tex N-terminal region-like	Ribonuclease H-like	6	4
HD-domain/PDEase-like	TGS-like	6	1
Frizzled cysteine-rich domain	Cytochromes	6	2
TPR-like	Protein prenylyltransferase	6	3
Siroheme synthase middle domains-like	Tetrapyrrole methylase	6	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	6	1
Docking domain B of the erythromycin polyketide synthase (DEBS)	FabD/lysophospholipase-like	6	1
SARS receptor-binding domain-like	Leucine zipper domain	6	1
	PGBD-like	6	2
Tex N-terminal region-like	RuvA domain 2-like	6	4
HMA, heavy metal-associated domain	FAD/NAD(P)-binding domain	6	1
NAD(P)-binding Rossmann-fold domains	Flavoproteins	6	1
PPK N-terminal domain-like	Phospholipase D/nuclease	6	1
Docking domain B of the erythromycin polyketide synthase (DEBS)	Probable ACP-binding domain of malonyl-CoA ACP transacylase	6	1
TTHA1013/TTHA0281-like	Ribbon-helix-helix	6	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	6	1
Aldolase	NAD(P)-binding Rossmann-fold domains	6	1
	Cystatin/monellin	6	1
	Dehydroquinate synthase-like	6	1
Formyltransferase	ACP-like	6	1
beta-sandwich domain of Sec23/24	beta-sandwich domain of Sec23/24	6	1
Staphylocoagulase	Staphylocoagulase	6	2
Periplasmic binding protein-like II	Voltage-gated potassium channels	6	1
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	6	1
ArfGap/RecO-like zinc finger	PH domain-like	6	1
Docking domain B of the erythromycin polyketide synthase (DEBS)	Thiolase-like	6	1
Family A G protein-coupled receptor-like	UDP-Glycosyltransferase/glycogen phosphorylase	6	2
Retrovirus capsid dimerization domain-like	CcmK-like	6	1
	ACT-like	6	1
Nucleotidylyl transferase	tRNA-binding arm	6	1
	DNase I-like	6	1
Mannose-binding lectins	Mannose-binding lectins	6	2
	TM1457-like	6	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	6	1
CoA-dependent acyltransferases	alpha/beta-Hydrolases	6	1
Sensory domain-like	Sensory domain-like	6	1
Chromo domain-like	S-adenosyl-L-methionine-dependent methyltransferases	6	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	6	1
Influenza hemagglutinin (stalk)	Fibritin	6	2
PHP14-like	Phospholipase D/nuclease	6	1
Class II aaRS and biotin synthetases	YbaK/ProRS associated domain	6	1
Viral protein domain	Fibritin	6	2
	Family A G protein-coupled receptor-like	6	1
Head-binding domain of phage P22 tailspike protein	Pectin lyase-like	6	1
Transcription factor NusA, N-terminal domain	Rad51 N-terminal domain-like	6	2
	ALDH-like	6	1
Staphylococcal nuclease	Staphylococcal nuclease	6	2
PYP-like sensor domain (PAS domain)	PH domain-like	6	1
Six-hairpin glycosidases	Starch-binding domain-like	6	2
Nucleic acid-binding proteins	Rad51 N-terminal domain-like	6	2
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	6	1
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	6	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	6	1
ADC-like	P-loop containing nucleoside triphosphate hydrolases	6	1
PH domain-like	BEACH domain	6	1
PH domain-like	SH3-domain	6	4
Hsp33 domain	HSP33 redox switch-like	6	1
	SAM/Pointed domain	6	2
	FMN-binding split barrel	6	1
Periplasmic binding protein-like II	Flavivirus capsid protein C	6	1
	alpha/beta-Hydrolases	6	1
Class I glutamine amidotransferase-like	PreATP-grasp domain	6	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	6	1
ADP-ribosylation	ADP-ribosylation	6	1
2Fe-2S ferredoxin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	6	3
P-loop containing nucleoside triphosphate hydrolases	GFP-like	6	2
Invasin/intimin cell-adhesion fragments	C-type lectin-like	6	2
HD-domain/PDEase-like	ACT-like	6	1
POZ domain	POZ domain	6	1
Prokaryotic type KH domain (KH-domain type II)	Rad51 N-terminal domain-like	6	2
Galactose oxidase, central domain	Kelch motif	6	2
"Winged helix" DNA-binding domain	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	6	1
	Head domain of nucleotide exchange factor GrpE	6	2
	TGS-like	6	1
Periplasmic binding protein-like II	Bcl-2 inhibitors of programmed cell death	6	1
Ubiquitin-like	SH3-domain	6	2
Serine metabolism enzymes domain	ACT-like	6	1
Cysteine proteinases	Ribonuclease H-like	6	1
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	6	1
	Subtilisin-like	6	4
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	6	1
Trimeric LpxA-like enzymes	ARM repeat	6	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	6	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	6	2
Carbamate kinase-like	ACT-like	6	1
ADC synthase	Class I glutamine amidotransferase-like	6	1
Nucleotide-diphospho-sugar transferases	Clavaminate synthase-like	6	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	6	1
HMA, heavy metal-associated domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	6	1
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	1
SNARE fusion complex	Clostridium neurotoxins, "coiled-coil" domain	6	1
LDL receptor-like module	EGF/Laminin	6	5
(Trans)glycosidases	gamma-Crystallin-like	6	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	6	1
Swiveling domain of dehydratase reactivase alpha subunit	Actin-like ATPase domain	6	1
Surface presentation of antigens (SPOA)	Surface presentation of antigens (SPOA)	6	2
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	6	1
TNF-like	TNF-like	6	3
	Rhodanese/Cell cycle control phosphatase	6	1
Glycosyl hydrolase domain	Ricin B-like lectins	6	1
	Calcium-dependent phosphotriesterase	6	2
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	6	3
Urease, beta-subunit	Metallo-dependent hydrolases	6	1
PDZ domain-like	Annexin	6	1
YbaK/ProRS associated domain	Class II aaRS ABD-related	6	1
Cystatin/monellin	Cystatin/monellin	6	2
PGBD-like	Lysozyme-like	6	2
Xylose isomerase-like	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	6	1
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	6	2
Uteroglobin-like	Uteroglobin-like	6	2
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	6	1
	Class II aaRS ABD-related	6	1
Carboxypeptidase regulatory domain-like	NHL repeat	6	3
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	6	1
RING/U-box	TRAF domain-like	6	1
Acetyl-CoA synthetase-like	alpha/beta-Hydrolases	6	1
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	6	3
Concanavalin A-like lectins/glucanases	Galactose-binding domain-like	6	4
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	6	1
Translation proteins	PRC-barrel domain	6	1
"Winged helix" DNA-binding domain	Phospholipase D/nuclease	6	1
TROVE domain-like	vWA-like	6	1
Kazal-type serine protease inhibitors	SRCR-like	6	2
Nucleotide-diphospho-sugar transferases	ARM repeat	6	1
XPC-binding domain	UBA-like	6	2
Nucleotidyltransferase	ACT-like	6	1
SRCR-like	LDL receptor-like module	6	2
Metalloproteases ("zincins"), catalytic domain	SNARE fusion complex	6	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	6	1
Nucleotidyltransferase	TGS-like	6	1
	DNA breaking-rejoining enzymes	6	1
Ribosomal protein L1	Ribosomal protein L1	6	1
	FAD-binding/transporter-associated domain-like	6	1
ARID-like	FYVE/PHD zinc finger	6	1
DinB/YfiT-like putative metalloenzymes	C-type lectin-like	6	1
NAD(P)-binding Rossmann-fold domains	Tetrapyrrole methylase	6	1
DBL homology domain (DH-domain)	PYP-like sensor domain (PAS domain)	6	1
Cullin repeat-like	"Winged helix" DNA-binding domain	6	1
	C-terminal UvrC-binding domain of UvrB	6	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	6	3
Urease, gamma-subunit	Metallo-dependent hydrolases	6	1
6-phosphogluconate dehydrogenase C-terminal domain-like	ACT-like	6	1
Phage fibre proteins	Fibritin	6	1
	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	6	1
	ACP-like	6	2
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	6	2
PPK N-terminal domain-like	PHP14-like	6	1
ARID-like	Clavaminate synthase-like	6	1
Retrovirus capsid protein, N-terminal core domain	CcmK-like	6	1
EGF/Laminin	Calcium-dependent phosphotriesterase	6	2
	Family A G protein-coupled receptor-like	6	4
Kazal-type serine protease inhibitors	LDL receptor-like module	6	2
BAH domain	Chromo domain-like	6	1
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	6	1
Actin-like ATPase domain	Protein kinase-like (PK-like)	6	2
S-adenosyl-L-methionine-dependent methyltransferases	Protein kinase-like (PK-like)	6	2
	Ricin B-like lectins	6	1
Peptide methionine sulfoxide reductase	Mss4-like	6	1
	Trypsin-like serine proteases	5	1
RING/U-box	beta-beta-alpha zinc fingers	5	2
FAS1 domain	FAS1 domain	5	3
TPR-like	RING/U-box	5	2
E set domains	3-carboxy-cis,cis-mucoante lactonizing enzyme	5	2
L27 domain	L27 domain	5	2
	Spermadhesin, CUB domain	5	2
	NAD(P)-linked oxidoreductase	5	1
EGF/Laminin	EF-hand	5	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	5	1
Ubiquitin-like	Moesin tail domain	5	1
E6 C-terminal domain-like	E6 C-terminal domain-like	5	2
FnI-like domain	Kringle-like	5	4
	IpsF-like	5	1
Integrin alpha N-terminal domain	Integrin alpha N-terminal domain	5	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	5	2
ThrRS/AlaRS common domain	Class II aaRS ABD-related	5	2
Cyclophilin-like	Single hybrid motif	5	2
	DNA topoisomerase IV, alpha subunit	5	1
Chelatase	Chelatase	5	2
Immunoglobulin	Concanavalin A-like lectins/glucanases	5	3
PH0987 N-terminal domain-like	Single hybrid motif	5	2
Rudiment single hybrid motif	Cyclophilin-like	5	2
Periplasmic binding protein-like II	(Phosphotyrosine protein) phosphatases II	5	1
EGF/Laminin	TSP type-3 repeat	5	2
Histidine-containing phosphotransfer domain, HPT domain	Histidine-containing phosphotransfer domain, HPT domain	5	2
Sema domain	Immunoglobulin	5	1
Bowman-Birk inhibitor, BBI	Bowman-Birk inhibitor, BBI	5	1
Ribonuclease H-like	mu transposase, C-terminal domain	5	2
	MCP/YpsA-like	5	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	PDZ domain-like	5	1
	Heme-dependent peroxidases	5	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	5	1
FAD/NAD(P)-binding domain	Cellulose-binding domain	5	2
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	5	3
FAD-linked reductases, C-terminal domain	Cellulose-binding domain	5	2
	Initiation factor IF2/eIF5b, domain 3	5	2
PreATP-grasp domain	Cyclophilin-like	5	2
Glutathione synthetase ATP-binding domain-like	Cyclophilin-like	5	2
PilZ domain-like	PilZ domain-like	5	1
Anthrax protective antigen	Putative glucosidase YicI, C-terminal domain	5	1
Fibronectin type III	BRCT domain	5	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	ACT-like	5	1
Hormone receptor domain	Family A G protein-coupled receptor-like	5	4
Kringle-like	Spermadhesin, CUB domain	5	2
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	5	3
Viral protein domain	Viral protein domain	5	2
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	5	1
	Restriction endonuclease-like	5	1
Rudiment single hybrid motif	PH0987 N-terminal domain-like	5	2
	Apical membrane antigen 1	5	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	5	3
SAM/Pointed domain	"Winged helix" DNA-binding domain	5	2
TB module/8-cys domain	Kazal-type serine protease inhibitors	5	1
Glutathione synthetase ATP-binding domain-like	PH0987 N-terminal domain-like	5	2
Colicin E3 receptor domain	His-Me finger endonucleases	5	2
gamma-Crystallin-like	gamma-Crystallin-like	5	2
Avidin/streptavidin	Avidin/streptavidin	5	2
Quinoprotein alcohol dehydrogenase-like	Cytochrome c	5	1
PH domain-like	Ras GEF	5	2
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	5	3
Ribosome recycling factor, RRF	Ribosome recycling factor, RRF	5	1
PGBD-like	Hemopexin-like domain	5	2
ARM repeat	GUN4-like	5	1
EGF/Laminin	Complement control module/SCR domain	5	2
	Perfringolysin	5	1
	Plexin repeat	5	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	5	4
TGS-like	Class II aaRS and biotin synthetases	5	2
RNA bacteriophage capsid protein	RNA bacteriophage capsid protein	5	1
	PriA/YqbF domain	5	1
UBA-like	UBA-like	5	3
Chaperone J-domain	Thioredoxin-like	5	2
SRCR-like	Trypsin-like serine proteases	5	1
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	5	3
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	5	2
Methionine synthase domain	Methionine synthase activation domain-like	5	1
beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	5	2
Galactose mutarotase-like	Anthrax protective antigen	5	1
Periplasmic binding protein-like II	Synuclein	5	1
	Subtilisin-like	5	1
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	5	3
TrmE connector domain	P-loop containing nucleoside triphosphate hydrolases	5	2
EGF/Laminin	Kazal-type serine protease inhibitors	5	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	5	1
TSP type-3 repeat	TSP type-3 repeat	5	2
Bacterial immunoglobulin/albumin-binding domains	Protein kinase-like (PK-like)	5	2
NAD(P)-binding Rossmann-fold domains	RmlC-like cupins	5	1
Plexin repeat	Immunoglobulin	5	1
alpha-helical ferredoxin	FAD/NAD(P)-binding domain	5	1
E set domains	Fibronectin type III	5	2
Galactose oxidase, central domain	Galactose oxidase, central domain	5	1
Cyclophilin-like	Cyclophilin-like	5	2
Hormone receptor domain	Lysozyme-like	5	1
Sec7 domain	RalF, C-terminal domain	5	3
Carbohydrate-binding domain	Type I dockerin domain	5	1
Periplasmic binding protein-like II	Bactericidal permeability-increasing protein, BPI	5	1
	Restriction endonuclease-like	5	1
Periplasmic binding protein-like II	Mitochondrial import receptor subunit Tom20	5	1
	Nuclear receptor ligand-binding domain	5	1
Second domain of FERM	Moesin tail domain	5	1
	Serpins	5	1
Aldolase	Single hybrid motif	5	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	5	1
Fic-like	Ankyrin repeat	5	1
	Ribosome inactivating proteins (RIP)	5	1
	Complement control module/SCR domain	5	2
Growth factor receptor domain	Calcium-dependent phosphotriesterase	5	1
Periplasmic binding protein-like II	Immunoglobulin	5	2
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	5	2
alpha-helical ferredoxin	ARM repeat	5	1
	Phosphoglucomutase, C-terminal domain	5	1
TGS-like	Class II aaRS ABD-related	5	2
RNA-binding domain, RBD	Clavaminate synthase-like	5	1
LDL receptor-like module	Calcium-dependent phosphotriesterase	5	4
CCCH zinc finger	RING/U-box	5	2
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	5	2
Galactose mutarotase-like	Starch-binding domain-like	5	1
	alpha-helical ferredoxin	5	1
DBL homology domain (DH-domain)	Ras GEF	5	2
gp120 core	IpsF-like	5	1
Origin of replication-binding domain, RBD-like	P-loop containing nucleoside triphosphate hydrolases	5	2
TPR-like	ARM repeat	5	2
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	5	1
Saposin	SGNH hydrolase	5	1
Cadherin-like	Dystroglycan, domain 2	5	1
	C-terminal effector domain of the bipartite response regulators	5	3
PH domain-like	Moesin tail domain	5	1
Kazal-type serine protease inhibitors	EF-hand	5	1
Starch-binding domain-like	Galactose-binding domain-like	5	1
Anthrax protective antigen	Glycosyl hydrolase domain	5	1
PreATP-grasp domain	PH0987 N-terminal domain-like	5	2
Chitinase insertion domain	Chitinase insertion domain	5	2
DNA topoisomerase I domain	DNA breaking-rejoining enzymes	5	1
Caspase-like	E set domains	5	1
Carbohydrate-binding domain	Carboxypeptidase regulatory domain-like	5	1
Arginase/deacetylase	Arginase/deacetylase	5	2
	Nucleotide cyclase	5	3
WW domain	Periplasmic binding protein-like II	4	1
	PK beta-barrel domain-like	4	1
Frizzled cysteine-rich domain	Flavoproteins	4	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	4	2
Carboxypeptidase regulatory domain-like	Calcium-dependent phosphotriesterase	4	1
Putative DNA-binding domain	P-loop containing nucleoside triphosphate hydrolases	4	1
GroES-like	ACP-like	4	1
Nucleic acid-binding proteins	BRCA2 tower domain	4	2
RNA-binding domain, RBD	PAP/OAS1 substrate-binding domain	4	1
POZ domain	Galactose oxidase, central domain	4	1
Fibronectin type III	Pectin lyase-like	4	1
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	4	1
Plexin repeat	EGF/Laminin	4	1
	Dimeric alpha+beta barrel	4	1
SH2 domain	RING/U-box	4	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	4	1
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	4	1
	Phosphotyrosine protein phosphatases I	4	1
Periplasmic binding protein-like I	Homeodomain-like	4	1
N-terminal domains of the minor coat protein g3p	TolA/TonB C-terminal domain	4	1
	Fibronectin type III	4	3
Chromo domain-like	DNA-binding domain of retroviral integrase	4	1
HBS1-like domain	P-loop containing nucleoside triphosphate hydrolases	4	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	4	1
Nucleic acid-binding proteins	BRCT domain	4	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	4	1
Tex N-terminal region-like	Nucleic acid-binding proteins	4	2
RNA-binding domain, RBD	Cyclophilin-like	4	1
Cyanovirin-N	LysM domain	4	2
Amidase signature (AS) enzymes	Cyclophilin-like	4	1
CheY-like	EAL domain-like	4	1
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	4	3
FabD/lysophospholipase-like	ACP-like	4	1
Calcium-dependent phosphotriesterase	WD40 repeat-like	4	2
Thioredoxin-like	NHL repeat	4	1
HBS1-like domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	4	1
	Class II aaRS and biotin synthetases	4	1
RING/U-box	B-box zinc-binding domain	4	2
Cu,Zn superoxide dismutase-like	Cu,Zn superoxide dismutase-like	4	1
	Enolase C-terminal domain-like	4	1
Snake toxin-like	Snake toxin-like	4	1
Snake toxin-like	Snake toxin-like	4	1
Tricorn protease N-terminal domain	alpha/beta-Hydrolases	4	1
EF-hand	Metallo-dependent phosphatases	4	1
Concanavalin A-like lectins/glucanases	ADP-ribosylation	4	1
LDL receptor-like module	Trypsin-like serine proteases	4	1
	FAD-linked reductases, C-terminal domain	4	2
Chromo domain-like	Homeodomain-like	4	2
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	4	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	4	1
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	4	1
Enolase C-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	4	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	4	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	4	1
E set domains	GFP-like	4	1
	SH2 domain	4	3
BRCA2 helical domain	Nucleic acid-binding proteins	4	2
TRAF domain-like	POZ domain	4	1
CCCH zinc finger	Tudor/PWWP/MBT	4	1
Concanavalin A-like lectins/glucanases	Exotoxin A, middle domain	4	1
Glutamine synthetase/guanido kinase	GAD domain-like	4	1
E set domains	Terpenoid cyclases/Protein prenyltransferases	4	1
YajQ-like	YajQ-like	4	1
	DNA-glycosylase	4	1
RNA-binding domain, RBD	RNA-binding domain, RBD	4	2
L domain-like	DNase I-like	4	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	4	1
Homeodomain-like	Probable bacterial effector-binding domain	4	1
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	PKD domain	4	1
Thiolase-like	alpha/beta-Hydrolases	4	1
L,D-transpeptidase pre-catalytic domain-like	L,D-transpeptidase catalytic domain-like	4	1
Cyclin-like	TATA-box binding protein-like	4	1
Non-globular alpha+beta subunits of globular proteins	Non-globular alpha+beta subunits of globular proteins	4	1
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	4	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	4	1
P-loop containing nucleoside triphosphate hydrolases	S-adenosyl-L-methionine-dependent methyltransferases	4	2
E set domains	Alpha-macroglobulin receptor domain	4	1
TSP type-3 repeat	OmpA-like	4	1
Fibronectin type III	Concanavalin A-like lectins/glucanases	4	2
Cytochrome c	E set domains	4	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	4	1
	TrpR-like	4	1
Exotoxin A, middle domain	ADP-ribosylation	4	1
ACT-like	PYP-like sensor domain (PAS domain)	4	1
Nucleic acid-binding proteins	Cytidine deaminase-like	4	1
"Winged helix" DNA-binding domain	HRDC-like	4	1
Cloacin translocation domain	Ribonuclease domain of colicin E3	4	1
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	4	1
EAL domain-like	Sensory domain-like	4	1
Translation proteins	"Winged helix" DNA-binding domain	4	2
Amidase signature (AS) enzymes	Single hybrid motif	4	1
LysM domain	(Trans)glycosidases	4	2
TAF(II)230 TBP-binding fragment	Bromodomain	4	2
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	4	1
Colicin E3 receptor domain	Ribonuclease domain of colicin E3	4	1
GroES-like	alpha/beta-Hydrolases	4	1
Amidase signature (AS) enzymes	Glutathione synthetase ATP-binding domain-like	4	1
GAD domain-like	GatB/YqeY motif	4	1
	Complement control module/SCR domain	4	1
Chaperone J-domain	CSL zinc finger	4	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	4	1
F-box domain	Galactose-binding domain-like	4	2
FF domain	FF domain	4	1
PhoU-like	TrkA C-terminal domain-like	4	1
Amidase signature (AS) enzymes	Rudiment single hybrid motif	4	1
Agglutinin	Agglutinin	4	1
Cystatin/monellin	Cysteine proteinases	4	1
	PK C-terminal domain-like	4	1
Homeodomain-like	NagB/RpiA/CoA transferase-like	4	1
F1F0 ATP synthase subunit B, membrane domain	V-type ATPase subunit E-like	4	1
Cell-division inhibitor MinC, N-terminal domain	Cell-division inhibitor MinC, C-terminal domain	4	1
Starch-binding domain-like	Starch-binding domain-like	4	2
IHF-like DNA-binding proteins	TraM-like	4	1
CBS-domain pair	Hypothetical protein Ta0289 C-terminal domain	4	1
MxiH-like	IpaD-like	4	1
S-adenosyl-L-methionine-dependent methyltransferases	GroES-like	4	1
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	4	2
POZ domain	Kelch motif	4	1
DAK1/DegV-like	DhaL-like	4	1
Homodimeric domain of signal transducing histidine kinase	CheW-like	4	1
(Trans)glycosidases	Six-hairpin glycosidases	4	1
Bacterial adhesins	Hypothetical protein PA1324	4	1
Carbohydrate-binding domain	Carbohydrate-binding domain	4	1
Carbohydrate-binding domain	Carbohydrate-binding domain	4	1
Bacterial luciferase-like	Bacterial luciferase-like	4	1
FabD/lysophospholipase-like	alpha/beta-Hydrolases	4	1
RuvA domain 2-like	BRCT domain	4	1
Tetrahydrobiopterin biosynthesis enzymes-like	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	4	1
GroEL equatorial domain-like	GroEL apical domain-like	4	2
Amidase signature (AS) enzymes	PreATP-grasp domain	4	1
HprK N-terminal domain-like	CBS-domain pair	4	1
alpha/beta knot	Nucleic acid-binding proteins	4	2
Family A G protein-coupled receptor-like	Flavoproteins	4	1
Ubiquitin-like	Kelch motif	4	1
L,D-transpeptidase catalytic domain-like	NTF2-like	4	1
Chaperone J-domain	T-antigen specific domain-like	4	1
Protein kinase-like (PK-like)	TPR-like	4	2
HBS1-like domain	Translation proteins	4	1
Voltage-gated potassium channels	GFP-like	4	1
PMT central region-like	Cysteine proteinases	4	1
Ankyrin repeat	SOCS box-like	4	1
Concanavalin A-like lectins/glucanases	AbfB domain	4	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	4	1
Sec7 domain	RalF, C-terminal domain	4	3
Sec7 domain	RalF, C-terminal domain	4	1
	Isochorismatase-like hydrolases	4	1
Peridinin-chlorophyll protein	Peridinin-chlorophyll protein	4	1
Peridinin-chlorophyll protein	Peridinin-chlorophyll protein	4	1
GatD N-terminal domain-like	Glutaminase/Asparaginase	4	1
Periplasmic binding protein-like II	Ankyrin repeat	4	1
Carbohydrate-binding domain	E set domains	4	1
Putative DNA-binding domain	Translation proteins	4	1
Zinc beta-ribbon	TATA-box binding protein-like	4	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha/beta-Hydrolases	4	1
(Trans)glycosidases	Anthrax protective antigen	4	2
	Acetamidase/Formamidase-like	4	1
	Ribosome inactivating proteins (RIP)	4	2
4-helical cytokines	4-helical cytokines	4	1
HAMP domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	4	1
beta-N-acetylhexosaminidase-like domain	E set domains	4	1
	Class II aaRS ABD-related	4	1
Quinoprotein alcohol dehydrogenase-like	Calcium-dependent phosphotriesterase	4	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	4	1
RNase A-like	RNase A-like	4	1
Ribbon-helix-helix	Replication modulator SeqA, C-terminal DNA-binding domain	4	1
FabD/lysophospholipase-like	GroES-like	4	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Bacterial immunoglobulin/albumin-binding domains	4	1
EreA/ChaN-like	Cysteine proteinases	4	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	4	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	4	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	4	2
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Phosphofructokinase	4	1
MoaD/ThiS	MoaD-related protein, C-terminal domain	4	1
FabD/lysophospholipase-like	S-adenosyl-L-methionine-dependent methyltransferases	4	1
Thiolase-like	S-adenosyl-L-methionine-dependent methyltransferases	4	1
	XRCC4, C-terminal oligomerization domain	4	1
Myosin rod fragments	Tropomyosin	4	1
SH3-domain	S-adenosyl-L-methionine-dependent methyltransferases	4	1
PYP-like sensor domain (PAS domain)	P-loop containing nucleoside triphosphate hydrolases	4	2
HMA, heavy metal-associated domain	HAD-like	4	2
Cloacin translocation domain	His-Me finger endonucleases	4	1
	Creatinase/aminopeptidase	4	1
Immunoglobulin-binding domains	Periplasmic binding protein-like II	4	1
BAR/IMD domain-like	SH3-domain	4	2
BRCA2 helical domain	BRCA2 tower domain	4	2
Complement control module/SCR domain	Immunoglobulin	4	2
Putative DNA-binding domain	Initiation factor IF2/eIF5b, domain 3	4	1
E set domains	NHL repeat	4	1
	FMN-linked oxidoreductases	4	1
Arabinanase/levansucrase/invertase	AbfB domain	4	1
Homeodomain-like	p53-like transcription factors	4	1
PUA domain-like	alpha/beta knot	4	2
Amidase signature (AS) enzymes	PH0987 N-terminal domain-like	4	1
Phase 1 flagellin	Phase 1 flagellin	4	1
Pre-protein crosslinking domain of SecA	Sec-C motif	4	2
Kazal-type serine protease inhibitors	Trypsin-like serine proteases	4	1
HAD-like	BRCT domain	4	1
Photosystem II antenna protein-like	Photosystem II antenna protein-like	4	1
Chromo domain-like	Ribonuclease H-like	4	1
Ankyrin repeat	Histidine-containing phosphotransfer domain, HPT domain	4	1
Thioredoxin-like	Nqo1C-terminal domain-like	4	1
Thiolase-like	GroES-like	4	1
	Trypsin-like serine proteases	4	1
S-adenosyl-L-methionine-dependent methyltransferases	ACP-like	4	1
Carbohydrate-binding domain	(Trans)glycosidases	4	1
NHL repeat	Calcium-dependent phosphotriesterase	4	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	4	1
all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	4	1
Periplasmic binding protein-like II	LexA/Signal peptidase	4	1
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	4	2
Calponin-homology domain, CH-domain	Spectrin repeat	4	2
Head morphogenesis protein gp7	Tropomyosin	4	1
Carbohydrate-binding domain	beta-N-acetylhexosaminidase-like domain	4	1
Microbial ribonucleases	Microbial ribonucleases	4	1
RNA-binding domain, RBD	Nucleotidyltransferase	4	1
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	1
Thioredoxin-like	Nqo1 middle domain-like	4	1
Ribonuclease H-like	Nucleic acid-binding proteins	4	2
	Composite domain of metallo-dependent hydrolases	4	1
Quinohemoprotein amine dehydrogenase A chain, domain 3	E set domains	4	1
Thioredoxin-like	Arabinanase/levansucrase/invertase	4	1
Thioredoxin-like	Nqo1 FMN-binding domain-like	4	1
C-type lectin-like	Complement control module/SCR domain	4	1
Cytidine deaminase-like	THUMP domain-like	4	1
Chromo domain-like	N-terminal Zn binding domain of HIV integrase	4	1
Six-hairpin glycosidases	Type I dockerin domain	4	2
	Sialidases	4	1
Cytochrome c	Quinohemoprotein amine dehydrogenase A chain, domain 3	4	1
ArfGap/RecO-like zinc finger	P-loop containing nucleoside triphosphate hydrolases	4	2
GAT-like domain	SNARE fusion complex	3	1
Subtilisin-like	Galactose-binding domain-like	3	1
5' to 3' exonuclease, C-terminal subdomain	Ribonuclease H-like	3	1
Ubiquitin-like	DNA clamp	3	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	PKD domain	3	1
	VP4 membrane interaction domain	3	1
ACT-like	CheY-like	3	1
	CheY-like	3	2
PYP-like sensor domain (PAS domain)	EAL domain-like	3	1
Concanavalin A-like lectins/glucanases	TRAF domain-like	3	1
PA2201 N-terminal domain-like	PA2201 C-terminal domain-like	3	1
TPR-like	SMAD/FHA domain	3	1
	Pectin lyase-like	3	1
Kringle-like	Hemopexin-like domain	3	1
ADP-ribosylation	Ricin B-like lectins	3	1
(Phosphotyrosine protein) phosphatases II	E set domains	3	1
	Bet v1-like	3	1
	vWA-like	3	2
LDL receptor-like module	Complement control module/SCR domain	3	1
E set domains	Hyaluronate lyase-like, C-terminal domain	3	1
Trimeric LpxA-like enzymes	NTF2-like	3	1
	Homeodomain-like	3	1
Bet v1-like	Bet v1-like	3	1
PAZ domain	dsRNA-binding domain-like	3	1
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	3	1
	dsRNA-binding domain-like	3	1
Helical scaffold and wing domains of SecA	Sec-C motif	3	1
GST C-terminal domain-like	GST C-terminal domain-like	3	1
C-terminal effector domain of the bipartite response regulators	TPR-like	3	1
MesJ substrate recognition domain-like	PheT/TilS domain	3	1
E set domains	YWTD domain	3	1
Flavoproteins	Rubredoxin-like	3	1
PIN domain-like	Ribonuclease H-like	3	1
C-terminal effector domain of the bipartite response regulators	SMAD/FHA domain	3	1
"Winged helix" DNA-binding domain	Riboflavin kinase-like	3	1
TSP-1 type 1 repeat	Complement control module/SCR domain	3	1
GLA-domain	Growth factor receptor domain	3	1
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	"Winged helix" DNA-binding domain	3	1
Concanavalin A-like lectins/glucanases	VP4 membrane interaction domain	3	1
Quinoprotein alcohol dehydrogenase-like	DPP6 N-terminal domain-like	3	1
Periplasmic binding protein-like II	Fibronectin type III	3	1
SH2 domain	GTPase activation domain, GAP	3	2
P-loop containing nucleoside triphosphate hydrolases	Sec-C motif	3	1
Phase 1 flagellin	Flagellar export chaperone FliS	3	2
Subunit IX of photosystem I reaction centre, PsaJ	Subunit III of photosystem I reaction centre, PsaF	3	1
HCP-like	TPR-like	3	1
Rab geranylgeranyltransferase alpha-subunit, insert domain	L domain-like	3	1
Periplasmic binding protein-like II	PAZ domain	3	1
Mib/herc2 domain-like	Mib/herc2 domain-like	3	1
Protein prenylyltransferase	Protein prenylyltransferase	3	1
	Duffy binding domain-like	3	1
Periplasmic binding protein-like II	beta-lactamase/transpeptidase-like	3	1
Spectrin repeat	EF-hand	3	1
Mannose 6-phosphate receptor domain	Kringle-like	3	2
Homeodomain-like	GFP-like	3	1
Quinoprotein alcohol dehydrogenase-like	Cytochrome c	3	1
Galactose-binding domain-like	Hyaluronate lyase-like, C-terminal domain	3	2
Zinc beta-ribbon	DNA primase core	3	1
Growth factor receptor domain	Trypsin-like serine proteases	3	1
Uracil-DNA glycosylase-like	PUA domain-like	3	1
Immunoglobulin-binding domains	RNA-binding domain, RBD	3	1
BT0923-like	BT0923-like	3	1
Arabinanase/levansucrase/invertase	Arabinanase/levansucrase/invertase	3	2
Carboxypeptidase regulatory domain-like	Porins	3	1
ARM repeat	GUN4-like	3	1
C-terminal domain of adenylylcyclase associated protein	Nucleoside diphosphate kinase, NDK	3	1
C-terminal domain of adenylylcyclase associated protein	Nucleoside diphosphate kinase, NDK	3	2
F-box domain	Galactose-binding domain-like	3	1
YegP-like	YegP-like	3	1
	FMN-dependent nitroreductase-like	3	2
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	3	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	3	2
Adhesin YadA, collagen-binding domain	Pili subunits	3	1
Adenine nucleotide alpha hydrolases-like	PheT/TilS domain	3	1
Ribonuclease H-like	RNA-binding domain, RBD	3	2
CBD9-like	FAD-linked reductases, C-terminal domain	3	1
Thioredoxin-like	TPR-like	3	1
Immunoglobulin	TSP-1 type 1 repeat	3	2
ARM repeat	RING/U-box	3	1
Calponin-homology domain, CH-domain	EF-hand	3	1
Cysteine-rich domain	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Mib/herc2 domain-like	RING/U-box	3	1
GTPase activation domain, GAP	P-loop containing nucleoside triphosphate hydrolases	3	2
Midkine	Midkine	3	1
Cysteine proteinases	UBA-like	3	2
Nucleic acid-binding proteins	PHP domain-like	3	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	3	1
ENTH/VHS domain	FYVE/PHD zinc finger	3	1
Metalloproteases ("zincins"), catalytic domain	TRAF domain-like	3	1
Metallo-hydrolase/oxidoreductase	Rubredoxin-like	3	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	3	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	3	1
GFP-like	Immunoglobulin	3	1
OMPA-like	OmpA-like	3	1
Surface presentation of antigens (SPOA)	Surface presentation of antigens (SPOA)	3	1
	RNase III domain-like	3	1
Chromo domain-like	Ankyrin repeat	3	2
Nucleic acid-binding proteins	TPR-like	3	2
Glutamine synthetase/guanido kinase	Glutathione synthetase ATP-binding domain-like	3	1
Cytochromes	GFP-like	3	1
Protein prenylyltransferase	Rab geranylgeranyltransferase alpha-subunit, insert domain	3	1
Hedgehog/intein (Hint) domain	Hedgehog/intein (Hint) domain	3	1
Creatinase/aminopeptidase	Creatinase/aminopeptidase	3	1
Protein prenylyltransferase	L domain-like	3	1
S-adenosyl-L-methionine-dependent methyltransferases	Macro domain-like	3	1
Periplasmic binding protein-like II	Bactericidal permeability-increasing protein, BPI	3	1
Fibre shaft of virus attachment proteins	Fibre shaft of virus attachment proteins	3	1
SRCR-like	SRCR-like	3	2
WD40 repeat-like	Nucleoporin domain	3	1
ENTH/VHS domain	SNARE fusion complex	3	1
Ferritin-like	Major capsid protein gp5	3	1
MFPT repeat-like	MFPT repeat-like	3	1
CheY-like	Ornithine decarboxylase C-terminal domain	3	1
Nucleic acid-binding proteins	AF1531-like	3	1
Carbohydrate-binding domain	E set domains	3	3
PIN domain-like	DNA/RNA polymerases	3	1
Protein kinase-like (PK-like)	Immunoglobulin	3	2
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	1
P-loop containing nucleoside triphosphate hydrolases	Ankyrin repeat	3	2
Protein prenylyltransferase	HCP-like	3	1
Plant lectins/antimicrobial peptides	Lysozyme-like	3	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	3	2
	RNase III domain-like	3	1
PGBD-like	L,D-transpeptidase catalytic domain-like	3	2
SWIB/MDM2 domain	eIF1-like	3	2
Second domain of FERM	Protein kinase-like (PK-like)	3	1
Immunoglobulin-binding domains	DEATH domain	3	2
TolB, N-terminal domain	Tricorn protease N-terminal domain	3	1
Cyclophilin-like	TPR-like	3	1
Surp module (SWAP domain)	Ubiquitin-like	3	1
Periplasmic binding protein-like II	Homeodomain-like	3	2
RING/U-box	Homeodomain-like	3	1
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	3	2
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	2
NTF2-like	NTF2-like	3	1
	Aquaporin-like	3	1
Spermadhesin, CUB domain	Complement control module/SCR domain	3	3
	dsRNA-binding domain-like	3	2
YhbC-like, N-terminal domain	YhbC-like, C-terminal domain	3	1
Pre-protein crosslinking domain of SecA	Sec-C motif	3	1
Photosystem II antenna protein-like	Photosystem II antenna protein-like	3	2
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	3	1
	PAZ domain	3	1
BAH domain	P-loop containing nucleoside triphosphate hydrolases	3	1
lambda repressor-like DNA-binding domains	SinR repressor dimerisation domain-like	3	1
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	3	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	3	2
Acid proteases	Saposin	3	1
CBD9-like	FAD/NAD(P)-binding domain	3	1
Periplasmic binding protein-like II	Tudor/PWWP/MBT	3	1
Defensin-like	Defensin-like	3	1
GFP-like	Periplasmic binding protein-like II	3	2
Ankyrin repeat	Second domain of FERM	3	1
Retroviral matrix proteins	Retrovirus capsid protein, N-terminal core domain	3	2
E set domains	Type I dockerin domain	3	1
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	3	2
CBD9-like	Cellulose-binding domain	3	1
GLA-domain	Kringle-like	3	2
5' to 3' exonuclease, C-terminal subdomain	DNA/RNA polymerases	3	1
Metallo-dependent phosphatases	Formin homology 2 domain (FH2 domain)	3	1
EGF/Laminin	Immunoglobulin	3	2
CheY-like	PLP-dependent transferases	3	1
E set domains	Chondroitin AC/alginate lyase	3	1
Galactose-binding domain-like	Chondroitin AC/alginate lyase	3	2
Homeodomain-like	SIS domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Acyl-CoA N-acyltransferases (Nat)	2	1
RNA-binding domain, RBD	NTF2-like	2	1
WW domain	Periplasmic binding protein-like II	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	2	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	2	1
FMN-binding split barrel	"Winged helix" DNA-binding domain	2	1
Periplasmic binding protein-like II	AFP III-like domain	2	1
	MIR domain	2	1
Sec7 domain	P-loop containing nucleoside triphosphate hydrolases	2	1
PX domain	SH3-domain	2	1
Leucine zipper domain	GTPase activation domain, GAP	2	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	2	1
L domain-like	Toll/Interleukin receptor TIR domain	2	1
Periplasmic binding protein-like II	Pre-protein crosslinking domain of SecA	2	1
Ribonuclease H-like	Zinc finger domain of DNA polymerase-alpha	2	1
Microbial ribonucleases	Plant inhibitors of proteinases and amylases	2	1
SPOC domain-like	SAP domain	2	1
lambda repressor-like DNA-binding domains	Tetracyclin repressor-like, C-terminal domain	2	1
Nucleic acid-binding proteins	Metallo-dependent phosphatases	2	1
(Trans)glycosidases	SH3-domain	2	1
Prokaryotic SH3-related domain	Prokaryotic SH3-related domain	2	2
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	2	1
Periplasmic binding protein-like II	Virus ectodomain	2	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	2	1
PH domain-like	C-terminal domain of PLC-beta	2	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	2	1
XRCC4, N-terminal domain	Head morphogenesis protein gp7	2	1
Ubiquitin-like	Cysteine proteinases	2	1
EGF/Laminin	Kringle-like	2	1
EGF/Laminin	TSP type-3 repeat	2	1
	R1 subunit of ribonucleotide reductase, N-terminal domain	2	1
Inhibitor of apoptosis (IAP) repeat	RNI-like	2	1
UBA-like	DNase I-like	2	1
Aconitase B, N-terminal domain	Aconitase iron-sulfur domain	2	1
Copper amine oxidase, domain N	Amine oxidase catalytic domain	2	1
Sialidases	Oligoxyloglucan reducing end-specific cellobiohydrolase	2	1
Rad51 N-terminal domain-like	Rad51 N-terminal domain-like	2	1
Homeodomain-like	Ribonuclease H-like	2	1
Cellulose docking domain, dockering	Cellulose docking domain, dockering	2	1
Phospholipase D/nuclease	TrmB C-terminal domain-like	2	2
Class II aaRS ABD-related	Class II aaRS ABD-related	2	1
SH3-domain	CAD & PB1 domains	2	1
	Dimeric alpha+beta barrel	2	1
Protein kinase-like (PK-like)	WD40 repeat-like	2	2
Ribokinase-like	Heme oxygenase-like	2	1
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	2	1
Ribosome inactivating proteins (RIP)	Ricin B-like lectins	2	1
RING/U-box	Concanavalin A-like lectins/glucanases	2	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Bacterial immunoglobulin/albumin-binding domains	ARM repeat	2	1
Head-binding domain of phage P22 tailspike protein	Leucine zipper domain	2	1
RING/U-box	WWE domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Lysozyme-like	2	1
B-box zinc-binding domain	Lysozyme-like	2	1
YrdC/RibB	RibA-like	2	1
RING/U-box	UBC-like	2	1
Cloacin translocation domain	Colicin D/E5 nuclease domain	2	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	1
Restriction endonuclease-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Ubiquitin-like	PP2C-like	2	1
Double Clp-N motif	GFP-like	2	1
Cellulose-binding domain	(Trans)glycosidases	2	1
Bacterial immunoglobulin/albumin-binding domains	Lysozyme-like	2	1
AFP III-like domain	AFP III-like domain	2	1
CBS-domain pair	ACT-like	2	1
Cytochrome c oxidase subunit I-like	Cytochrome c oxidase subunit III-like	2	1
Serine protease inhibitors	FnI-like domain	2	1
Retroviral matrix proteins	Retrovirus zinc finger-like domains	2	1
	FliG	2	1
P-loop containing nucleoside triphosphate hydrolases	CarD-like	2	1
Quinoprotein alcohol dehydrogenase-like	TolB, C-terminal domain	2	1
Periplasmic binding protein-like II	Arginase/deacetylase	2	1
2Fe-2S ferredoxin-like	Actin-like ATPase domain	2	1
Ribosome inactivating proteins (RIP)	Ribosome inactivating proteins (RIP)	2	1
	Homodimeric domain of signal transducing histidine kinase	2	1
CCHHC domain	CCHHC domain	2	1
Calponin-homology domain, CH-domain	E set domains	2	1
DNA-binding pseudobarrel domain	Restriction endonuclease-like	2	1
"Winged helix" DNA-binding domain	Rv2827c C-terminal domain-like	2	1
	SpoIIaa-like	2	1
BSD domain-like	BSD domain-like	2	1
"Winged helix" DNA-binding domain	Ras GEF	2	1
Beta-D-glucan exohydrolase, C-terminal domain	Beta-D-glucan exohydrolase, C-terminal domain	2	1
Carbon-nitrogen hydrolase	HIT-like	2	1
Transcription factor STAT-4 N-domain	SH2 domain	2	1
SAM/Pointed domain	Lysozyme-like	2	1
Six-hairpin glycosidases	CBD9-like	2	1
IHF-like DNA-binding proteins	IHF-like DNA-binding proteins	2	1
CbiG N-terminal domain-like	CobE/GbiG C-terminal domain-like	2	1
Transcription factor STAT-4 N-domain	p53-like transcription factors	2	1
Protein kinase-like (PK-like)	UBA-like	2	1
RAP domain-like	RAP domain-like	2	1
Galactose-binding domain-like	Agglutinin HPA-like	2	1
	UROD/MetE-like	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	1
Retroviral matrix proteins	Retrovirus capsid dimerization domain-like	2	1
Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	2	1
FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	2	1
Homeodomain-like	mu transposase, C-terminal domain	2	1
Heme-dependent catalase-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	1
SH2 domain	Cysteine-rich domain	2	1
	DHS-like NAD/FAD-binding domain	2	1
	CAD & PB1 domains	2	1
Apolipoprotein A-I	Apolipoprotein A-I	2	1
	PurM C-terminal domain-like	2	1
CarD-like	TRCF domain-like	2	1
Single hybrid motif	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	2	1
	cAMP-binding domain-like	2	1
Trypsin-like serine proteases	EGF/Laminin	2	2
PTS-regulatory domain, PRD	PTS-regulatory domain, PRD	2	1
PDZ domain-like	Fibronectin type III	2	1
CheY-like	Ribulose-phoshate binding barrel	2	1
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	2	1
Nucleotide-diphospho-sugar transferases	IpsF-like	2	1
	PFL-like glycyl radical enzymes	2	1
Periplasmic binding protein-like II	ACP-like	2	1
gamma-Crystallin-like	gamma-Crystallin-like	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	2	1
PR-1-like	PR-1-like	2	1
FKBP-like	EF-hand	2	1
beta-beta-alpha zinc fingers	Leucine zipper domain	2	1
	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	2	1
Ubiquitin-like	UBA-like	2	1
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	2	1
Periplasmic binding protein-like II	Concanavalin A-like lectins/glucanases	2	1
Dihydrofolate reductase-like	Dihydrofolate reductase-like	2	1
Chaperone J-domain	Protein kinase-like (PK-like)	2	1
Cna protein B-type domain	vWA-like	2	2
Topoisomerase V catalytic domain-like	Rad51 N-terminal domain-like	2	2
Arabinanase/levansucrase/invertase	Arabinanase/levansucrase/invertase	2	2
Tex N-terminal region-like	SH2 domain	2	2
Ubiquitin-like	XPC-binding domain	2	1
lambda repressor-like DNA-binding domains	LexA/Signal peptidase	2	1
Periplasmic binding protein-like II	ClpS-like	2	1
Histone-fold	PH domain-like	2	2
PH domain-like	PDZ domain-like	2	2
Ubiquitin-like	WD40 repeat-like	2	1
CHY zinc finger-like	Zinc hairpin stack	2	1
SGNH hydrolase	Autotransporter	2	1
Leucine zipper domain	Ubiquitin-like	2	1
YegP-like	YegP-like	2	1
beta-carbonic anhydrase, cab	beta-carbonic anhydrase, cab	2	1
beta-carbonic anhydrase, cab	beta-carbonic anhydrase, cab	2	1
Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	2	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	2	1
PKD domain	Galactose-binding domain-like	2	1
Cell-division inhibitor MinC, N-terminal domain	Cell-division inhibitor MinC, C-terminal domain	2	1
Periplasmic binding protein-like II	4'-phosphopantetheinyl transferase	2	1
Second domain of FERM	SH3-domain	2	1
Cystine-knot cytokines	Heparin-binding domain from vascular endothelial growth factor	2	1
Ubiquitin-like	SH3-domain	2	1
DNA/RNA polymerases	Zinc finger domain of DNA polymerase-alpha	2	1
CheY-like	Methylesterase CheB, C-terminal domain	2	1
Eea1 homodimerisation domain	FYVE/PHD zinc finger	2	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	ARM repeat	2	1
"Winged helix" DNA-binding domain	Ubiquitin-like	2	1
RuvA domain 2-like	Rad51 N-terminal domain-like	2	2
Influenza hemagglutinin (stalk)	Virus ectodomain	2	1
WW domain	EF-hand	2	1
Cadherin-like	(Trans)glycosidases	2	1
Bacterial adhesins	Hypothetical protein PA1324	2	1
Bacterial adhesins	Hypothetical protein PA1324	2	1
	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	2	1
	WW domain	2	2
EF-hand	Ubiquitin-like	2	1
"Winged helix" DNA-binding domain	DPP6 N-terminal domain-like	2	1
Tp47 lipoprotein, middle and C-terminal domains	Tp47 lipoprotein, middle and C-terminal domains	2	1
Annexin	Annexin	2	1
Trypsin-like serine proteases	DNA/RNA polymerases	2	1
Plant lectins/antimicrobial peptides	N-acetylmuramoyl-L-alanine amidase-like	2	1
Metallo-hydrolase/oxidoreductase	Rubredoxin-like	2	1
Heme-dependent catalase-like	Lipoxigenase	2	1
Viral protein domain	Virus ectodomain	2	1
	Lysozyme-like	2	2
Pili subunits	GspK insert domain-like	2	1
	EAL domain-like	2	1
CoA-dependent acyltransferases	Thiamin diphosphate-binding fold (THDP-binding)	2	1
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	2	1
	Substrate-binding domain of HMG-CoA reductase	2	1
	Sortase	2	1
Prokaryotic SH3-related domain	Cysteine proteinases	2	1
Aconitase B, N-terminal domain	LeuD/IlvD-like	2	1
Aldolase	FKBP-like	2	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	2	1
Creatinase/aminopeptidase	Creatinase/aminopeptidase	2	1
Sialidases	Six-hairpin glycosidases	2	1
	Metallo-hydrolase/oxidoreductase	2	1
	SMAD/FHA domain	2	1
	SH3-domain	2	1
Concanavalin A-like lectins/glucanases	Ricin B-like lectins	2	1
SET domain	TAFH domain-like	2	1
beta and beta-prime subunits of DNA dependent RNA-polymerase	beta and beta-prime subunits of DNA dependent RNA-polymerase	2	2
(Trans)glycosidases	Cyclophilin-like	2	1
Soluble quinoprotein glucose dehydrogenase	WD40 repeat-like	2	1
Galactose-binding domain-like	Heparin-binding domain from vascular endothelial growth factor	2	1
R3H domain	RNA-binding domain, RBD	2	1
Cysteine-rich domain	GTPase activation domain, GAP	2	1
NE0471 N-terminal domain-like	lambda repressor-like DNA-binding domains	2	1
Soluble quinoprotein glucose dehydrogenase	EGF/Laminin	2	1
SH2 domain	Fibronectin type III	2	1
Class II aaRS and biotin synthetases	Class II aaRS and biotin synthetases	2	1
BAG domain	BAG domain	2	1
RING/U-box	UBA-like	2	1
	DAK1/DegV-like	2	1
Aromatic compound dioxygenase	Carbohydrate binding domain	2	1
PRP4-like	WD40 repeat-like	2	1
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	2	2
PYP-like sensor domain (PAS domain)	C-terminal effector domain of the bipartite response regulators	2	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cytochrome c	2	1
Growth factor receptor domain	TNF receptor-like	2	1
PH domain-like	BSD domain-like	2	1
Sigma3 and sigma4 domains of RNA polymerase sigma factors	NTF2-like	2	1
Ubiquitin-like	Thymidylate synthase/dCMP hydroxymethylase	2	1
Clc chloride channel	Carbon-nitrogen hydrolase	2	1
NTF2-like	UBA-like	2	1
Actin depolymerizing proteins	RNI-like	2	1
	Class I glutamine amidotransferase-like	2	1
Class I glutamine amidotransferase-like	Ferritin-like	2	1
EF-hand	P-loop containing nucleoside triphosphate hydrolases	2	1
	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	1
EF-hand	C-terminal domain of PLC-beta	2	1
Transcription factor STAT-4 N-domain	STAT	2	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
HSP20-like chaperones	HSP20-like chaperones	2	1
	Acetyl-CoA synthetase-like	2	1
	Cysteine proteinases	2	1
Calponin-homology domain, CH-domain	PH domain-like	2	1
Lysozyme-like	PH domain-like	2	1
Ribulose-phoshate binding barrel	PRTase-like	2	1
E set domains	alpha/beta-Hydrolases	2	1
PriA/YqbF domain	Rho N-terminal domain-like	2	1
GroEL equatorial domain-like	GroEL equatorial domain-like	2	1
PX domain	CAD & PB1 domains	2	1
TRAF domain-like	Cysteine proteinases	2	1
S-adenosyl-L-methionine-dependent methyltransferases	Protein-L-isoaspartyl O-methyltransferase, C-terminal domain	2	1
Starch-binding domain-like	(Phosphotyrosine protein) phosphatases II	2	1
	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	1
LDL receptor-like module	Calcium-dependent phosphotriesterase	2	1
	Carbonic anhydrase	2	1
Periplasmic binding protein-like II	Clavaminate synthase-like	2	1
Family A G protein-coupled receptor-like	Immunoglobulin	2	2
RuvA domain 2-like	SH2 domain	2	2
	FumA C-terminal domain-like	2	1
Histone-fold	ARM repeat	2	1
Viral glycoprotein, central and dimerisation domains	Viral glycoprotein, central and dimerisation domains	2	1
Lysozyme-like	Cytochromes	2	1
vWA-like	SAP domain	2	1
Sigma2 domain of RNA polymerase sigma factors	NTF2-like	2	1
LysM domain	Cysteine proteinases	2	1
Staphylokinase/streptokinase	Staphylokinase/streptokinase	2	1
PYP-like sensor domain (PAS domain)	SpoIIaa-like	2	1
Tp47 lipoprotein, N-terminal domain	Tp47 lipoprotein, middle and C-terminal domains	2	1
Phase 1 flagellin	Phase 1 flagellin	2	2
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	2	1
HP0242-like	HP0242-like	2	1
	ASF1-like	2	1
Ribonuclease H-like	SH2 domain	2	2
	KA1-like	2	1
Bacterial GAP domain	(Phosphotyrosine protein) phosphatases II	2	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	2	1
delta-Endotoxin (insectocide), N-terminal domain	Mannose-binding lectins	2	1
GspK insert domain-like	GspK insert domain-like	2	1
	Myosin rod fragments	2	1
EF-hand	Thioredoxin-like	2	1
4Fe-4S ferredoxins	Adenine nucleotide alpha hydrolases-like	2	1
Bromodomain	RING/U-box	2	1
Periplasmic binding protein-like II	cAMP-binding domain-like	2	1
Thioredoxin-like	FMN-dependent nitroreductase-like	2	1
	Protein prenylyltransferase	2	1
Galactose mutarotase-like	CBD9-like	2	1
Ankyrin repeat	FabD/lysophospholipase-like	2	1
ROP protein	ROP protein	2	1
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	2	1
Isochorismatase-like hydrolases	ACP-like	2	1
	Chitinase insertion domain	2	1
I/LWEQ domain	alpha-catenin/vinculin-like	2	1
CBD9-like	PHM/PNGase F	2	1
E set domains	CBD9-like	2	1
DinB/YfiT-like putative metalloenzymes	SCP-like	2	1
Ribbon-helix-helix	Tetramerization domain of the Mnt repressor	2	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
Beta-D-glucan exohydrolase, C-terminal domain	Galactose-binding domain-like	2	1
	Terpenoid synthases	2	1
	Autotransporter	2	1
RNA-binding domain, RBD	Ran binding protein zinc finger-like	2	1
Leucine zipper domain	Nucleotide cyclase	2	1
Fibronectin type III	Protein kinase-like (PK-like)	2	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	2	1
Peptidoglycan deacetylase N-terminal noncatalytic region	Glycoside hydrolase/deacetylase	2	1
4Fe-4S ferredoxins	DHS-like NAD/FAD-binding domain	2	1
	Galactose-binding domain-like	2	1
Immunoglobulin-binding domains	UBA-like	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	2	1
	NAD-binding domain of HMG-CoA reductase	2	1
Cyanovirin-N	Cyanovirin-N	2	1
Six-hairpin glycosidases	Six-hairpin glycosidases	2	1
Inhibitor of apoptosis (IAP) repeat	P-loop containing nucleoside triphosphate hydrolases	2	1
WWE domain	WWE domain	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	1	1
Inhibitor of apoptosis (IAP) repeat	RING/U-box	1	1
beta-sandwich domain of Sec23/24	ARM repeat	1	1
Immunoglobulin-binding domains	Carboxypeptidase regulatory domain-like	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Hairpin loop containing domain-like	Hairpin loop containing domain-like	1	1
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	1	1
	Histidine-containing phosphotransfer domain, HPT domain	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
ALDH-like	ALDH-like	1	1
FwdE-like	Glucocorticoid receptor-like (DNA-binding domain)	1	1
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	1	1
	Ribokinase-like	1	1
Homing endonucleases	YcfA/nrd intein domain	1	1
NHL repeat	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Globin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
	FKBP-like	1	1
	HMA, heavy metal-associated domain	1	1
N-terminal domains of the minor coat protein g3p	TolA/TonB C-terminal domain	1	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	1	1
Cysteine-rich domain	Cysteine-rich domain	1	1
Ubiquitin-like	BAG domain	1	1
Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	1	1
C-terminal domain of Ku80	C-terminal domain of Ku80	1	1
Colicin Ia, N-terminal domain	Colicin	1	1
Zn-dependent exopeptidases	Prokaryotic SH3-related domain	1	1
Ribosomal protein S5 domain 2-like	Cna protein B-type domain	1	1
DNA breaking-rejoining enzymes	"Winged helix" DNA-binding domain	1	1
Perfringolysin	Concanavalin A-like lectins/glucanases	1	1
LigB-like	LigA subunit of an aromatic-ring-opening dioxygenase LigAB	1	1
p53-like transcription factors	"Winged helix" DNA-binding domain	1	1
Fic-like	"Winged helix" DNA-binding domain	1	1
SET domain	Ankyrin repeat	1	1
	UBA-like	1	1
	CCCH zinc finger	1	1
PH domain-like	Cullin repeat-like	1	1
Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	1	1
SMAD/FHA domain	SMAD/FHA domain	1	1
NHL repeat	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Cna protein B-type domain	1	1
Doublecortin (DC)	Doublecortin (DC)	1	1
Phosphoglycerate kinase	Phosphoglycerate kinase	1	1
F-box domain	Ankyrin repeat	1	1
Single hybrid motif	Single hybrid motif	1	1
N-utilization substance G protein NusG, N-terminal domain	N-utilization substance G protein NusG, N-terminal domain	1	1
N-utilization substance G protein NusG, N-terminal domain	N-utilization substance G protein NusG, N-terminal domain	1	1
Sema domain	Immunoglobulin	1	1
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Zinc beta-ribbon	Prokaryotic SH3-related domain	1	1
Nucleotide-diphospho-sugar transferases	Cell wall binding repeat	1	1
	Hect, E3 ligase catalytic domain	1	1
PK beta-barrel domain-like	Phosphohistidine domain	1	1
RNA-binding domain, RBD	Bacterial immunoglobulin/albumin-binding domains	1	1
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Immunoglobulin-binding domains	CAD & PB1 domains	1	1
Trypsin-like serine proteases	Trypsin-like serine proteases	1	1
	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
	DNase I-like	1	1
Periplasmic binding protein-like II	E6 C-terminal domain-like	1	1
"Winged helix" DNA-binding domain	GAD domain-like	1	1
SH3-domain	GTPase activation domain, GAP	1	1
Ubiquitin-like	HAD-like	1	1
	FKBP-like	1	1
Uracil-DNA glycosylase-like	Pre-PUA domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	1	1
cAMP-binding domain-like	"Winged helix" DNA-binding domain	1	1
PHM/PNGase F	Calcium-dependent phosphotriesterase	1	1
Ran binding protein zinc finger-like	SMAD/FHA domain	1	1
Periplasmic binding protein-like II	Activating enzymes of the ubiquitin-like proteins	1	1
PKD domain	Immunoglobulin	1	1
Ubiquitin-like	PP2C-like	1	1
Glu-tRNAGln amidotransferase C subunit	Nucleotidylyl transferase	1	1
SacY-like RNA-binding domain	PTS-regulatory domain, PRD	1	1
Histidine-containing phosphotransfer domain, HPT domain	CheY-binding domain of CheA	1	1
GFP-like	Ubiquitin-like	1	1
Ribosomal protein L25-like	GatB/YqeY motif	1	1
Cysteine-rich domain	Protein kinase-like (PK-like)	1	1
WGR domain-like	RNI-like	1	1
Tachylectin-2	NHL repeat	1	1
Ribbon-helix-helix	FAD-linked oxidoreductase	1	1
Thyroglobulin type-1 domain	Thymidylate synthase/dCMP hydroxymethylase	1	1
	Glycosyl hydrolase domain	1	1
Microbial ribonucleases	Ubiquitin-like	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
Galactose-binding domain-like	Immunoglobulin	1	1
	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
Ferritin-like	Ferritin-like	1	1
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	1	1
Histone-fold	DBL homology domain (DH-domain)	1	1
Periplasmic binding protein-like I	Periplasmic binding protein-like I	1	1
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	1	1
Leucine zipper domain	NAD(P)-binding Rossmann-fold domains	1	1
	Phase 1 flagellin	1	1
SAM/Pointed domain	"Winged helix" DNA-binding domain	1	1
RecG, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
N-acetylmuramoyl-L-alanine amidase-like	Cell wall binding repeat	1	1
Single hybrid motif	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
Ras GEF	Cysteine-rich domain	1	1
Rhodanese/Cell cycle control phosphatase	FKBP-like	1	1
CCCH zinc finger	Retrovirus zinc finger-like domains	1	1
Signal recognition particle alu RNA binding heterodimer, SRP9/14	Signal recognition particle alu RNA binding heterodimer, SRP9/14	1	1
Glu-tRNAGln amidotransferase C subunit	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Growth factor receptor domain	TB module/8-cys domain	1	1
Cloacin translocation domain	Colicin	1	1
Pectin lyase-like	PKD domain	1	1
Alpha-L RNA-binding motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
FnI-like domain	EGF/Laminin	1	1
Sec-C motif	NTF2-like	1	1
PH domain-like	Ras GEF	1	1
Carbohydrate-binding domain	Fibronectin type III	1	1
Carboxypeptidase regulatory domain-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
HRDC-like	HRDC-like	1	1
Uracil-DNA glycosylase-like	PUA domain-like	1	1
TAF(II)230 TBP-binding fragment	Bromodomain	1	1
Folate-binding domain	TrmE connector domain	1	1
D-aminopeptidase, middle and C-terminal domains	D-aminopeptidase, middle and C-terminal domains	1	1
PX domain	PH domain-like	1	1
Cadherin-like	Glycosyl hydrolase domain	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
	Peptide deformylase	1	1
Metallo-hydrolase/oxidoreductase	Cell wall binding repeat	1	1
Chaperone J-domain	CSL zinc finger	1	1
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
Flagellar hook protein flgE	Flagellar hook protein flgE	1	1
WD40 repeat-like	DPP6 N-terminal domain-like	1	1
Cytochrome c	Multiheme cytochromes	1	1
NAD(P)-binding Rossmann-fold domains	Galactose mutarotase-like	1	1
X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain	alpha/beta-Hydrolases	1	1
Chaperone J-domain	Thioredoxin-like	1	1
EGF/Laminin	Fibronectin type III	1	1
SAM/Pointed domain	ARM repeat	1	1
	SpoIIaa-like	1	1
Oxygen-evolving enhancer protein 3,	Cyclophilin-like	1	1
Transcription factor IIA (TFIIA), beta-barrel domain	Transcription factor IIA (TFIIA), beta-barrel domain	1	1
LEM domain	LEM domain	1	1
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like II	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
	HMG-box	1	1
CAD & PB1 domains	His-Me finger endonucleases	1	1
ACP-like	ACP-like	1	1
Voltage-gated potassium channels	Leucine zipper domain	1	1
Nitrile hydratase alpha chain	Nitrile hydratase alpha chain	1	1
SH2 domain	Ubiquitin-like	1	1
Cadherin-like	(Trans)glycosidases	1	1
D-lysine 5,6-aminomutase beta subunit KamE, N-terminal domain	Cobalamin (vitamin B12)-binding domain	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
Single hybrid motif	FAD/NAD(P)-binding domain	1	1
Nucleotidylyl transferase	GatB/YqeY motif	1	1
Ubiquitin-like	Ribosomal protein S5 domain 2-like	1	1
Mannose-binding lectins	Kelch motif	1	1
Hedgehog/intein (Hint) domain	YcfA/nrd intein domain	1	1
	SGNH hydrolase	1	1
AbrB/MazE/MraZ-like	AbrB/MazE/MraZ-like	1	1
E set domains	Prokaryotic SH3-related domain	1	1
Thioredoxin-like	Family A G protein-coupled receptor-like	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	1	1
	Lipocalins	1	1
	Voltage-gated potassium channels	1	1
Nucleic acid-binding proteins	PHP domain-like	1	1
FliG	FliG	1	1
"Winged helix" DNA-binding domain	TrmB C-terminal domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	1	1
Heme-dependent catalase-like	Lipoxigenase	1	1
	Lysozyme-like	1	1
	Virus ectodomain	1	1
Plakin repeat	Plakin repeat	1	1
beta-beta-alpha zinc fingers	WW domain	1	1
Heterotrimerisation domain of extracellular hemoglobin linker subunits	Extracellular hemoglobin linker subunit, receptor domain	1	1
Pectin lyase-like	Autotransporter	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1
	Penicillin-binding protein 2x (pbp-2x), c-terminal domain	1	1
Ferritin-like	Spectrin repeat	1	1
SAP domain	SAP domain	1	1
Ribbon-helix-helix	Ribbon-helix-helix	1	1
	Cobalamin adenosyltransferase-like	1	1
HSP90 C-terminal domain	Cna protein B-type domain	1	1
gp120 core	Virus ectodomain	1	1
Sigma2 domain of RNA polymerase sigma factors	C-terminal effector domain of the bipartite response regulators	1	1
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	1	1
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	1	1
PGBD-like	Hedgehog/DD-peptidase	1	1
	Putative methyltransferase TM0872, insert domain	1	1
GDNF receptor-like	GDNF receptor-like	1	1
"Winged helix" DNA-binding domain	NagB/RpiA/CoA transferase-like	1	1
Immunoglobulin-binding domains	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
	cAMP-binding domain-like	1	1
Elafin-like	Fibronectin type III	1	1
Putative DNA-binding domain	Antibiotic binding domain of TipA-like multidrug resistance regulators	1	1
	Subunit III of photosystem I reaction centre, PsaF	1	1
Ribosomal protein L13	Ribosomal protein L13	1	1
Plant proteinase inhibitors	Plant proteinase inhibitors	1	1
beta-N-acetylhexosaminidase-like domain	Galactose-binding domain-like	1	1
Restriction endonuclease-like	Rad51 N-terminal domain-like	1	1
	Nuclear receptor ligand-binding domain	1	1
Ran binding protein zinc finger-like	"Winged helix" DNA-binding domain	1	1
Inhibitor of apoptosis (IAP) repeat	DEATH domain	1	1
	Aspartate/ornithine carbamoyltransferase	1	1
Ferritin-like	Nucleotide cyclase	1	1
His-Me finger endonucleases	DNA-binding domain of intron-encoded endonucleases	1	1
Helical scaffold and wing domains of SecA	Helical scaffold and wing domains of SecA	1	1
Acetyl-CoA synthetase-like	Thiolase-like	1	1
Nop domain	Nop domain	1	1
Ribbon-helix-helix	N-terminal domain of bifunctional PutA protein	1	1
FYVE/PHD zinc finger	RNA-binding domain, RBD	1	1
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	Rubredoxin-like	1	1
Prismane protein-like	alpha-helical ferredoxin	1	1
	Cysteine proteinases	1	1
L domain-like	Prokaryotic SH3-related domain	1	1
Stathmin	Stathmin	1	1
	RalF, C-terminal domain	1	1
Histone-fold	Ras GEF	1	1
Bet v1-like	NAD(P)-binding Rossmann-fold domains	1	1
Leucine zipper domain	TNF-like	1	1
Ribulose-phoshate binding barrel	NAD(P)-binding Rossmann-fold domains	1	1
	eIF1-like	1	1
Group V grass pollen allergen	Group V grass pollen allergen	1	1
X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain	Galactose-binding domain-like	1	1
V-type ATP synthase subunit C	V-type ATP synthase subunit C	1	1
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
Growth factor receptor domain	Kazal-type serine protease inhibitors	1	1
PH domain-like	Ran binding protein zinc finger-like	1	1
Galactose-binding domain-like	SGNH hydrolase	1	1
Ribosomal protein S2	Nucleic acid-binding proteins	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
	Subdomain of clathrin and coatomer appendage domain	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
"Winged helix" DNA-binding domain	Putative transcriptional regulator TM1602, C-terminal domain	1	1
Acyl-CoA N-acyltransferases (Nat)	tRNA-binding arm	1	1
WD40 repeat-like	Cyclophilin-like	1	1
	Fibritin	1	1
	Aquaporin-like	1	1
SH2 domain	ARM repeat	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	1	1
vWA-like	SAP domain	1	1
PH domain-like	FYVE/PHD zinc finger	1	1
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	1	1
Cupredoxins	Immunoglobulin	1	1
Hyaluronidase post-catalytic domain-like	Galactose-binding domain-like	1	1
Ras GEF	EF-hand	1	1
Putative DNA-binding domain	Initiation factor IF2/eIF5b, domain 3	1	1
C-terminal domain of transcriptional repressors	C-terminal domain of transcriptional repressors	1	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	Quinoprotein alcohol dehydrogenase-like	1	1
BPTI-like	LDL receptor-like module	1	1
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	1	1
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
	KA1-like	1	1
omega toxin-like	omega toxin-like	1	1
Periplasmic binding protein-like II	FKBP-like	1	1
A middle domain of Talin 1	I/LWEQ domain	1	1
Folate-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Periplasmic binding protein-like II	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	1	1
Actin-like ATPase domain	TPR-like	1	1
Cullin repeat-like	"Winged helix" DNA-binding domain	1	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), alpha-helical domain	1	1
EF-hand	Cysteine-rich domain	1	1
PUA domain-like	eIF1-like	1	1
Carboxypeptidase regulatory domain-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
RecG, N-terminal domain	Nucleic acid-binding proteins	1	1
Collagen-binding domain	Collagen-binding domain	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	1	1
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	1	1
	Diaminopimelate epimerase-like	1	1
Ricin B-like lectins	Fibronectin type III	1	1
(Trans)glycosidases	Fibronectin type III	1	1
Gamma-glutamyl cyclotransferase-like	Gamma-glutamyl cyclotransferase-like	1	1
	UBC-like	1	1
Metalloproteases ("zincins"), catalytic domain	PDZ domain-like	1	1
Acetyl-CoA synthetase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Periplasmic binding protein-like II	WD40 repeat-like	1	1
	GatB/YqeY motif	1	1
TNF-like	Periplasmic binding protein-like I	1	1
E set domains	Carbohydrate binding domain	1	1
Sec-C motif	Sec-C motif	1	1
beta-lactamase/transpeptidase-like	D-aminopeptidase, middle and C-terminal domains	1	1
Ubiquitin-like	JAB1/MPN domain	1	1
	Prion-like	1	1
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
GFP-like	Thioredoxin-like	1	1
	PLP-binding barrel	1	1
	SWIB/MDM2 domain	1	1
Immunoglobulin-binding domains	NHL repeat	1	1
WD40 repeat-like	Peptidase/esterase 'gauge' domain	1	1
EGF/Laminin	Calcium-dependent phosphotriesterase	1	1
Rudiment single hybrid motif	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	1	1
Concanavalin A-like lectins/glucanases	Cadherin-like	1	1
CBS-domain pair	FAD-binding/transporter-associated domain-like	1	1
Ribosomal protein S6	Ribosomal protein S6	1	1
DEATH domain	RING/U-box	1	1
DEATH domain	RING/U-box	1	1
YbaK/ProRS associated domain	HD-domain/PDEase-like	1	1
	eEF-1beta-like	1	1
SH3-domain	Immunoglobulin-binding domains	1	1
	LeuD/IlvD-like	1	1
	Clathrin adaptor appendage domain	1	1
Fe-S cluster assembly (FSCA) domain-like	Fe-S cluster assembly (FSCA) domain-like	1	1