Domain combination pairs in Protozoadb 2010_08

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

2197 domain combination pairs.
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Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	2208	211
Ankyrin repeat	Ankyrin repeat	1370	106
L domain-like	L domain-like	1176	79
Actin-like ATPase domain	Actin-like ATPase domain	1067	32
Ribonuclease H-like	DNA/RNA polymerases	825	16
Growth factor receptor domain	Growth factor receptor domain	724	112
RNA-binding domain, RBD	RNA-binding domain, RBD	620	50
Sialidases	Concanavalin A-like lectins/glucanases	576	5
TPR-like	TPR-like	541	47
ARM repeat	ARM repeat	517	69
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	496	47
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	494	14
Protein kinase-like (PK-like)	ARM repeat	460	53
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	459	38
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	449	34
HAD-like	Calcium ATPase, transmembrane domain M	448	35
Ankyrin repeat	Pseudo ankyrin repeat-like	438	17
Calcium ATPase, transduction domain A	HAD-like	419	30
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	382	25
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	373	22
GroEL apical domain-like	GroEL equatorial domain-like	370	13
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	362	15
GroEL equatorial domain-like	GroEL-intermediate domain like	361	10
GroEL-intermediate domain like	GroEL apical domain-like	358	9
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	354	19
WD40 repeat-like	WD40 repeat-like	337	48
Protein kinase-like (PK-like)	Ankyrin repeat	312	41
Protein kinase-like (PK-like)	PH domain-like	297	21
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	283	15
Homeodomain-like	Homeodomain-like	272	24
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	270	5
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	266	28
Thioredoxin-like	Thioredoxin-like	260	25
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	250	24
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	248	36
Growth factor receptor domain	Protein kinase-like (PK-like)	244	45
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	240	19
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	226	16
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	226	9
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	216	11
Nucleic acid-binding proteins	Nucleic acid-binding proteins	214	30
ABC transporter transmembrane region	ABC transporter transmembrane region	214	19
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	210	31
BEACH domain	WD40 repeat-like	210	24
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	204	4
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	200	4
EF-G C-terminal domain-like	EF-G C-terminal domain-like	200	39
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	199	11
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	193	34
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	192	10
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	185	30
Translation proteins	EF-G C-terminal domain-like	185	33
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	179	7
ARM repeat	Clathrin adaptor appendage domain	177	12
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	170	20
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	170	14
Protein kinase-like (PK-like)	EF-hand	167	20
Ubiquitin-like	UBA-like	166	23
Cyclin-like	Cyclin-like	166	10
PH domain-like	BEACH domain	164	22
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	162	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	161	11
Cullin homology domain	"Winged helix" DNA-binding domain	159	11
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	158	15
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	152	27
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	149	5
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	149	24
beta-sandwich domain of Sec23/24	vWA-like	147	23
cAMP-binding domain-like	cAMP-binding domain-like	146	35
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	146	19
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	143	9
EF-hand	EF-hand	143	28
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	142	15
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	141	9
Zn-finger domain of Sec23/24	vWA-like	140	19
Translation proteins SH3-like domain	Nucleic acid-binding proteins	140	4
Pectin lyase-like	Pectin lyase-like	138	22
Duffy binding domain-like	Duffy binding domain-like	136	23
Translation proteins	Ribosomal protein S5 domain 2-like	135	22
PH domain-like	WD40 repeat-like	134	16
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	134	21
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	133	6
SNARE-like	SNARE fusion complex	131	5
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	128	14
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	128	9
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	128	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	128	7
RING/U-box	RING/U-box	126	17
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	125	24
HCP-like	HCP-like	124	29
Cullin repeat-like	Cullin homology domain	124	12
DBL homology domain (DH-domain)	PH domain-like	124	19
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	124	14
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	123	20
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	123	14
MFS general substrate transporter	MFS general substrate transporter	123	8
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	122	12
CCCH zinc finger	CCCH zinc finger	120	11
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	114	10
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	114	14
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	113	11
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	110	14
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	110	14
Cullin repeat-like	"Winged helix" DNA-binding domain	110	8
Major surface antigen p30, SAG1	Major surface antigen p30, SAG1	109	8
RNI-like	RNI-like	109	25
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	108	37
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	108	29
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	108	14
GAF domain-like	HD-domain/PDEase-like	107	15
P-loop containing nucleoside triphosphate hydrolases	TGS-like	107	3
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	107	13
vWA-like	Helical domain of Sec23/24	106	13
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	105	7
Thiolase-like	Thiolase-like	105	12
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	105	12
GroES-like	NAD(P)-binding Rossmann-fold domains	104	13
GAF domain-like	GAF domain-like	104	16
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	102	15
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	102	15
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	100	10
FYVE/PHD zinc finger	FYVE/PHD zinc finger	99	28
Subtilisin-like	Galactose-binding domain-like	99	5
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	99	12
(Trans)glycosidases	Glycosyl hydrolase domain	96	13
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	95	7
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	93	7
ARM repeat	WD40 repeat-like	91	23
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	91	7
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	91	4
Concanavalin A-like lectins/glucanases	BEACH domain	91	15
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	90	16
Glutathione synthetase ATP-binding domain-like	PreATP-grasp domain	88	21
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	88	11
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	88	10
ADC-like	P-loop containing nucleoside triphosphate hydrolases	86	10
Sec63 N-terminal domain-like	E set domains	85	30
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	84	2
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	84	12
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	82	6
Periplasmic binding protein-like I	Nucleotide cyclase	81	6
Chromo domain-like	Chromo domain-like	81	13
Ubiquitin-like	Ubiquitin-like	80	16
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	79	9
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	78	3
Thioredoxin-like	GST C-terminal domain-like	76	8
BAR/IMD domain-like	SH3-domain	76	5
RCC1/BLIP-II	RCC1/BLIP-II	75	17
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	75	12
Translation proteins	Initiation factor IF2/eIF5b, domain 3	74	11
TPR-like	Chaperone J-domain	74	12
RING/U-box	SMAD/FHA domain	74	10
L domain-like	PP2C-like	74	9
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	74	32
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	73	2
Ankyrin repeat	RING/U-box	73	17
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	72	7
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	72	4
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	72	6
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	71	4
EGF/Laminin	EGF/Laminin	71	15
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	71	3
Macro domain-like	Zn-dependent exopeptidases	70	3
ADC-like	Cdc48 domain 2-like	70	6
Flavoproteins	Riboflavin synthase domain-like	69	14
Kelch motif	Kelch motif	69	13
L domain-like	RNI-like	68	29
Nucleotidylyl transferase	Ribosomal protein L25-like	68	8
SMAD/FHA domain	Protein kinase-like (PK-like)	68	6
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	68	10
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	68	16
Nucleotidylyl transferase	Nucleotidylyl transferase	68	9
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	68	8
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	67	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	67	6
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	67	13
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	67	7
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	66	6
Concanavalin A-like lectins/glucanases	WD40 repeat-like	66	10
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	66	4
Smp-1-like	Cysteine proteinases	65	4
Ubiquitin-like	Zn-binding ribosomal proteins	64	3
Translational machinery components	L30e-like	63	5
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	63	19
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	63	4
P-loop containing nucleoside triphosphate hydrolases	E set domains	63	28
RING/U-box	Cysteine proteinases	63	10
RNA-binding domain, RBD	WW domain	62	17
TATA-box binding protein-like	TATA-box binding protein-like	62	7
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	62	5
E set domains	E set domains	61	19
DNA clamp	DNA clamp	61	4
Enolase N-terminal domain-like	Enolase C-terminal domain-like	61	4
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	61	4
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	61	5
Concanavalin A-like lectins/glucanases	PH domain-like	60	11
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	60	3
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	60	27
(Phosphotyrosine protein) phosphatases II	L domain-like	60	12
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	60	6
PK beta-barrel domain-like	PK C-terminal domain-like	59	4
Single hybrid motif	CoA-dependent acyltransferases	59	11
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	58	6
ARM repeat	Subdomain of clathrin and coatomer appendage domain	58	5
RING/U-box	WD40 repeat-like	57	8
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	57	17
UBA-like	UBA-like	57	14
FYVE/PHD zinc finger	PH domain-like	56	6
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	56	11
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	56	6
Ribosomal protein L6	Ribosomal protein L6	55	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	55	11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	54	10
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	54	12
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	54	9
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	54	2
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	54	7
DUSP-like	Cysteine proteinases	53	5
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	53	5
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	53	2
TSP-1 type 1 repeat	TSP-1 type 1 repeat	52	18
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	52	4
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	52	5
FKBP-like	TPR-like	52	8
Actin depolymerizing proteins	Actin depolymerizing proteins	51	13
POZ domain	Skp1 dimerisation domain-like	50	3
Nucleotide cyclase	Nucleotide cyclase	50	11
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	50	2
Sec7 domain	ARM repeat	50	13
Restriction endonuclease-like	RuvA domain 2-like	49	5
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	49	22
t-snare proteins	SNARE fusion complex	49	4
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	49	14
Tricorn protease domain 2	WD40 repeat-like	49	14
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	49	14
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	48	14
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	48	7
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	48	3
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	48	9
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	47	10
SAM/Pointed domain	Protein kinase-like (PK-like)	47	10
Cysteine proteinases	Cysteine proteinases	47	10
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	47	4
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	47	11
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	47	11
L domain-like	Protein kinase-like (PK-like)	46	12
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	46	22
Phospholipase D/nuclease	Phospholipase D/nuclease	46	7
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	46	6
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	46	5
Zinc beta-ribbon	Cyclin-like	46	6
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	46	9
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	45	12
Translation proteins	ThrRS/AlaRS common domain	45	6
Galactose-binding domain-like	LCCL domain	45	7
BRCT domain	BRCT domain	45	13
ARM repeat	Formin homology 2 domain (FH2 domain)	44	5
Kelch motif	POZ domain	44	11
ClpP/crotonase	ClpP/crotonase	44	9
PH domain-like	PH domain-like	44	18
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	44	9
PH domain-like	ArfGap/RecO-like zinc finger	44	9
Chaperone J-domain	Thioredoxin-like	44	6
Glucocorticoid receptor-like (DNA-binding domain)	P-loop containing nucleoside triphosphate hydrolases	43	12
Galactose-binding domain-like	Galactose-binding domain-like	43	10
Ribonuclease H-like	Ribonuclease H-like	43	7
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	43	3
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	42	17
UBA-like	XPC-binding domain	42	12
Galactose mutarotase-like	(Trans)glycosidases	42	3
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	42	5
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	42	8
(Phosphotyrosine protein) phosphatases II	Protein kinase-like (PK-like)	42	10
Pre-PUA domain	PUA domain-like	41	3
"Winged helix" DNA-binding domain	E set domains	41	18
FYSH domain	Hypothetical protein AF0491, middle domain	41	4
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	41	20
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	41	10
MIT domain	P-loop containing nucleoside triphosphate hydrolases	40	3
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	40	7
HMG-box	HMG-box	40	9
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	40	6
TPR-like	Metallo-dependent phosphatases	40	2
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	40	3
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	40	4
Protein kinase-like (PK-like)	HCP-like	40	14
Ricin B-like lectins	Galactose-binding domain-like	40	7
HAD-like	BRCT domain	39	5
Ribosomal L27 protein-like	Nucleic acid-binding proteins	39	6
Ricin B-like lectins	LCCL domain	39	7
RING/U-box	Homeodomain-like	39	6
Metallo-dependent phosphatases	EF-hand	39	8
RNA-binding domain, RBD	PABC (PABP) domain	39	5
Galactose mutarotase-like	Glycosyl hydrolase domain	39	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	38	4
SH3-domain	SH3-domain	38	9
Tropomyosin	Tropomyosin	38	18
Metallo-dependent hydrolases	Metallo-dependent hydrolases	38	3
Class II aaRS ABD-related	C-terminal domain of ProRS	38	5
GTPase activation domain, GAP	PH domain-like	38	7
4Fe-4S ferredoxins	Fe-only hydrogenase	38	6
FYVE/PHD zinc finger	SET domain	38	12
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	38	7
Ubiquitin-like	Cysteine proteinases	38	8
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	37	2
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	37	4
PH domain-like	Ankyrin repeat	37	10
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	37	3
Pseudouridine synthase	Pseudouridine synthase	37	7
WD40 repeat-like	DPP6 N-terminal domain-like	37	10
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	37	15
Phosphofructokinase	Phosphofructokinase	37	6
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	37	6
Variant surface glycoprotein (N-terminal domain)	Variant surface glycoprotein MITAT 1.2, VSG 221, C-terminal domain	36	3
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	36	9
Putative DNA-binding domain	Class II aaRS and biotin synthetases	36	5
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	36	5
Metallo-hydrolase/oxidoreductase	Flavoproteins	36	3
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	36	3
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	36	5
TPR-like	ARM repeat	36	14
tRNA-binding arm	Class II aaRS and biotin synthetases	36	6
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	36	5
GINS helical bundle-like	PriA/YqbF domain	36	6
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Protein kinase-like (PK-like)	36	10
P-loop containing nucleoside triphosphate hydrolases	vWA-like	35	14
ARM repeat	Hect, E3 ligase catalytic domain	35	9
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	35	2
ACP-like	NAD(P)-binding Rossmann-fold domains	35	14
PreATP-grasp domain	Rudiment single hybrid motif	35	7
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	35	7
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	35	5
Staphylococcal nuclease	Staphylococcal nuclease	35	9
Rudiment single hybrid motif	Single hybrid motif	35	7
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	35	7
PreATP-grasp domain	Single hybrid motif	35	7
Folate-binding domain	Aminomethyltransferase beta-barrel domain	35	6
Dcp2 domain-like	Nudix	35	3
Class II aaRS and biotin synthetases	Translation proteins	34	4
ThrRS/AlaRS common domain	Class II aaRS ABD-related	34	4
Galactose-binding domain-like	Fibrinogen C-terminal domain-like	34	4
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	34	4
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	34	11
Starch-binding domain-like	(Trans)glycosidases	34	8
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	34	4
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	34	7
PP2C-like	PP2C-like	34	5
Ankyrin repeat	FabD/lysophospholipase-like	34	2
PLP-binding barrel	Alanine racemase C-terminal domain-like	34	6
Ubiquitin-like	XPC-binding domain	34	9
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	34	15
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	34	3
Ricin B-like lectins	Fibrinogen C-terminal domain-like	34	4
Pseudouridine synthase	PUA domain-like	34	3
Putative DNA-binding domain	Putative DNA-binding domain	33	3
Periplasmic binding protein-like I	Periplasmic binding protein-like I	33	5
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	33	4
Clc chloride channel	CBS-domain pair	33	5
P-loop containing nucleoside triphosphate hydrolases	EF-hand	33	7
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	33	4
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	33	2
Dom34/Pelota N-terminal domain-like	L30e-like	33	3
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	32	4
alpha-helical ferredoxin	Nucleotide-binding domain	32	10
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	32	2
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	32	3
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	32	4
Nucleic acid-binding proteins	eIF2alpha middle domain-like	32	4
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	31	2
Dom34/Pelota N-terminal domain-like	Translational machinery components	31	2
RNA-binding domain, RBD	RING/U-box	31	7
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	31	2
Protein kinase-like (PK-like)	Polo-box domain	31	5
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	31	2
Staphylococcal nuclease	Tudor/PWWP/MBT	31	7
Zinc beta-ribbon	Zinc beta-ribbon	31	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	31	3
Fibrinogen C-terminal domain-like	LCCL domain	31	3
Cap-Gly domain	Ubiquitin-like	31	8
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	31	2
ARM repeat	RING/U-box	31	5
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	31	5
Nucleotide-binding domain	FAD/NAD(P)-binding domain	31	8
Ubiquitin-like	ARM repeat	31	3
DHS-like NAD/FAD-binding domain	Formate/glycerate dehydrogenase catalytic domain-like	31	4
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	31	3
SNARE-like	Domain of the SRP/SRP receptor G-proteins	31	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	31	5
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SAM/Pointed domain	30	7
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	30	5
TPR-like	SET domain	30	5
E set domains	(Trans)glycosidases	30	9
Cysteine-rich domain	Cysteine-rich domain	30	7
Ribonuclease H-like	HRDC-like	30	2
PRTase-like	PRTase-like	30	4
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	30	6
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	29	11
Thioredoxin-like	Ubiquitin-like	29	6
NAD(P)-binding Rossmann-fold domains	NagB/RpiA/CoA transferase-like	29	5
Ubiquitin-like	Protein kinase-like (PK-like)	29	2
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NagB/RpiA/CoA transferase-like	29	5
DHS-like NAD/FAD-binding domain	NAD(P)-binding Rossmann-fold domains	29	3
Chaperone J-domain	beta-beta-alpha zinc fingers	29	2
Clathrin heavy-chain terminal domain	ARM repeat	29	9
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	29	3
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	29	2
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	29	4
ThrRS/AlaRS common domain	P-loop containing nucleoside triphosphate hydrolases	29	4
GST C-terminal domain-like	eEF1-gamma domain	29	3
Thioredoxin-like	ERP29 C domain-like	29	4
cAMP-binding domain-like	Protein kinase-like (PK-like)	28	6
WW domain	FF domain	28	10
Hairpin loop containing domain-like	Hairpin loop containing domain-like	28	11
Starch-binding domain-like	Starch-binding domain-like	28	6
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	28	4
Acetyl-CoA synthetase-like	ACP-like	28	9
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	28	4
CCCH zinc finger	RNA-binding domain, RBD	28	5
ArfGap/RecO-like zinc finger	Ankyrin repeat	28	5
Nucleotide-binding domain	FMN-linked oxidoreductases	28	7
vWA-like	TSP-1 type 1 repeat	28	12
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	28	4
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	28	9
(Trans)glycosidases	Galactose-binding domain-like	28	11
FYVE/PHD zinc finger	Protein kinase-like (PK-like)	28	8
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	28	3
Chaperone J-domain	Homeodomain-like	27	5
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	27	16
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	27	3
YbaK/ProRS associated domain	Class II aaRS and biotin synthetases	27	5
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	27	8
WW domain	WW domain	27	7
HSP20-like chaperones	HCP-like	27	5
Mitochondrial carrier	Mitochondrial carrier	27	5
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	27	8
HAD-like	HAD-like	27	8
Tropomyosin	Myosin rod fragments	27	13
RING/U-box	UBA-like	27	6
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	27	4
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	26	8
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	26	2
TK C-terminal domain-like	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	26	5
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	26	5
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	26	3
Thiamin diphosphate-binding fold (THDP-binding)	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	26	5
Single hybrid motif	ClpP/crotonase	26	5
Calponin-homology domain, CH-domain	PH domain-like	26	6
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	26	7
YbaK/ProRS associated domain	Class II aaRS ABD-related	26	4
F-box domain	WD40 repeat-like	26	3
BRCT domain	post-AAA+ oligomerization domain-like	26	3
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	25	2
GST C-terminal domain-like	Nucleotidylyl transferase	25	6
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	25	3
CBS-domain pair	cAMP-binding domain-like	25	4
LCCL domain	Concanavalin A-like lectins/glucanases	25	5
vWA-like	Cysteine-rich domain	25	4
FYVE/PHD zinc finger	RING/U-box	25	6
WD40 repeat-like	TPR-like	25	14
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	25	2
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	25	6
Taf5 N-terminal domain-like	WD40 repeat-like	25	4
PRP4-like	WD40 repeat-like	25	4
P-loop containing nucleoside triphosphate hydrolases	ARM repeat	25	9
Alpha-L RNA-binding motif	Pseudouridine synthase	24	3
Metallo-hydrolase/oxidoreductase	SCP-like	24	2
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	24	6
Actin depolymerizing proteins	VHP, Villin headpiece domain	24	7
Ubiquitin-like	Acid proteases	24	4
Ankyrin repeat	Ypt/Rab-GAP domain of gyp1p	24	3
PH domain-like	(Phosphotyrosine protein) phosphatases II	24	4
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	24	5
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	24	10
YbaK/ProRS associated domain	C-terminal domain of ProRS	24	3
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	24	4
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	24	3
Protein kinase-like (PK-like)	KA1-like	24	3
TATA-box binding protein-like	DNA-glycosylase	24	4
EF-hand	PLC-like phosphodiesterases	24	7
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	24	9
SET domain	SET domain	24	7
CCCH zinc finger	RING/U-box	24	4
Polo-box domain	Polo-box domain	23	3
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	23	7
Chaperone J-domain	Sec63 N-terminal domain-like	23	4
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	23	6
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	23	5
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	23	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	23	3
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	23	10
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	23	4
UBC-like	Protein kinase-like (PK-like)	23	4
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	23	4
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	23	4
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	23	4
PLP-dependent transferases	PLP-dependent transferases	23	4
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	23	4
L domain-like	Outer arm dynein light chain 1	23	12
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	23	3
Chaperone J-domain	E set domains	23	4
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	23	5
CoA-dependent acyltransferases	CoA-dependent acyltransferases	23	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	23	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	P-loop containing nucleoside triphosphate hydrolases	23	2
TPR-like	HCP-like	23	10
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	23	6
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	23	6
ARM repeat	PH domain-like	22	10
FF domain	FF domain	22	6
EGF/Laminin	Growth factor receptor domain	22	10
DBL homology domain (DH-domain)	Kelch motif	22	3
UBA-like	Homeodomain-like	22	7
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	22	2
Thiamin diphosphate-binding fold (THDP-binding)	4Fe-4S ferredoxins	22	4
TK C-terminal domain-like	4Fe-4S ferredoxins	22	4
Acyl-CoA binding protein	Ankyrin repeat	22	3
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	22	3
Cyclophilin-like	RNA-binding domain, RBD	22	5
Aconitase iron-sulfur domain	LeuD/IlvD-like	22	3
PH domain-like	EF-hand	22	7
Class I glutamine amidotransferase-like	PreATP-grasp domain	22	8
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	22	2
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	22	5
Galactose oxidase, central domain	Kelch motif	22	8
Carbamoyl phosphate synthetase, large subunit connection domain	Glutathione synthetase ATP-binding domain-like	22	9
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	4Fe-4S ferredoxins	22	4
Carbamoyl phosphate synthetase, large subunit connection domain	PreATP-grasp domain	22	9
GroES-like	GroES-like	22	8
DBL homology domain (DH-domain)	ARM repeat	22	5
Nucleotide-diphospho-sugar transferases	ARM repeat	22	6
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	21	8
Succinyl-CoA synthetase domains	Succinyl-CoA synthetase domains	21	5
FabD/lysophospholipase-like	FabD/lysophospholipase-like	21	7
vWA-like	vWA-like	21	12
P-loop containing nucleoside triphosphate hydrolases	RCC1/BLIP-II	21	6
DNase I-like	DNase I-like	21	4
WD40 repeat-like	Cyclophilin-like	21	3
CRAL/TRIO domain	GTPase activation domain, GAP	21	4
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	21	6
Lipase/lipooxygenase domain (PLAT/LH2 domain)	LCCL domain	21	3
Anthrax protective antigen	LCCL domain	21	7
E set domains	Glycosyl hydrolase domain	21	5
SET domain	HIT/MYND zinc finger-like	21	4
EF-hand	WD40 repeat-like	21	11
LCCL domain	SRCR-like	21	3
RNA-binding domain, RBD	Surp module (SWAP domain)	21	5
Lipase/lipooxygenase domain (PLAT/LH2 domain)	SRCR-like	21	3
Rudiment single hybrid motif	ClpP/crotonase	20	4
PH domain-like	Oxysterol-binding protein-like	20	5
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	20	4
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	20	4
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	20	7
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	20	7
Galactose-binding domain-like	ARM repeat	20	4
Ankyrin repeat	TPR-like	20	3
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	20	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	20	4
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	20	7
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	20	7
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	20	5
PreATP-grasp domain	ClpP/crotonase	20	4
PreATP-grasp domain	Methylglyoxal synthase-like	20	7
PUA domain-like	eIF1-like	20	3
Calcium ATPase, transmembrane domain M	Nucleotide cyclase	20	7
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	20	4
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	20	7
vWA-like	SPOC domain-like	20	5
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	EF-hand	20	3
PAZ domain	Ribonuclease H-like	20	4
Hect, E3 ligase catalytic domain	Hect, E3 ligase catalytic domain	20	9
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	20	7
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	20	7
Translation proteins	Translation proteins	20	6
Chaperone J-domain	CSL zinc finger	20	3
DBL homology domain (DH-domain)	ArfGap/RecO-like zinc finger	20	4
Calponin-homology domain, CH-domain	ArfGap/RecO-like zinc finger	20	4
TPR-like	"Winged helix" DNA-binding domain	20	3
POZ domain	Galactose-binding domain-like	20	4
Protein kinase-like (PK-like)	WD40 repeat-like	19	9
LCCL domain	LCCL domain	19	2
SMAD/FHA domain	SMAD/FHA domain	19	4
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	19	4
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	19	4
Tropomyosin	Smc hinge domain	19	8
Surp module (SWAP domain)	Surp module (SWAP domain)	19	3
RNI-like	Protein kinase-like (PK-like)	19	7
Thioredoxin-like	eEF1-gamma domain	19	2
RNI-like	Cysteine proteinases	19	5
Thioredoxin-like	FAD-dependent thiol oxidase	19	1
SRCR-like	Concanavalin A-like lectins/glucanases	19	2
RING/U-box	B-box zinc-binding domain	19	6
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	19	2
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	19	4
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	19	2
GST C-terminal domain-like	Nucleic acid-binding proteins	19	3
Calcium ATPase, transduction domain A	Nucleotide cyclase	19	6
Ankyrin repeat	Bromodomain	19	2
SRCR-like	SRCR-like	19	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	19	11
ThrRS/AlaRS common domain	Nucleotidylyl transferase	19	3
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	19	2
ACP-like	Thiolase-like	19	11
PRP4-like	Functional domain of the splicing factor Prp18	19	4
Glucocorticoid receptor-like (DNA-binding domain)	RING/U-box	19	7
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Concanavalin A-like lectins/glucanases	19	2
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	19	3
TRAF domain-like	Cysteine proteinases	18	4
PreATP-grasp domain	PreATP-grasp domain	18	5
Ankyrin repeat	Hect, E3 ligase catalytic domain	18	5
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	18	5
HAD-like	P-loop containing nucleoside triphosphate hydrolases	18	3
DHS-like NAD/FAD-binding domain	Thiamin diphosphate-binding fold (THDP-binding)	18	5
Cdc48 domain 2-like	RING/U-box	18	3
ARM repeat	"Winged helix" DNA-binding domain	18	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	18	5
Phosphoglycerate mutase-like	Phosphoglycerate mutase-like	18	7
Class II aaRS and biotin synthetases	SufE/NifU	18	1
alpha/beta-Hydrolases	alpha/beta-Hydrolases	18	8
HAD-like	Nucleotide cyclase	18	6
EF-hand	SAICAR synthase-like	18	2
Sec7 domain	PH domain-like	18	2
Nucleic acid-binding proteins	TPR-like	18	8
ARM repeat	Rap/Ran-GAP	18	4
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	18	5
WD40 repeat-like	Cysteine-rich domain	18	3
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	18	2
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	18	5
PurM N-terminal domain-like	PurM C-terminal domain-like	18	4
Flavoproteins	Radical SAM enzymes	18	3
AN1-like Zinc finger	AN1-like Zinc finger	18	2
BEACH domain	Quinoprotein alcohol dehydrogenase-like	18	4
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	18	3
Calponin-homology domain, CH-domain	EF-hand	18	4
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	18	1
TPR-like	Activator of Hsp90 ATPase, Aha1	18	2
NAD kinase/diacylglycerol kinase-like	NAD kinase/diacylglycerol kinase-like	18	6
UBC-like	RING/U-box	17	3
Trimeric LpxA-like enzymes	ARM repeat	17	5
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	17	5
alpha-helical ferredoxin	FMN-linked oxidoreductases	17	5
RING/U-box	EF-hand	17	3
Kelch motif	Protein kinase-like (PK-like)	17	4
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	17	8
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	17	3
CHY zinc finger-like	RING/U-box	17	4
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	17	9
beta and beta-prime subunits of DNA dependent RNA-polymerase	beta and beta-prime subunits of DNA dependent RNA-polymerase	17	4
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	17	3
DNA breaking-rejoining enzymes	DNA/RNA polymerases	17	2
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	17	3
UBA-like	PUG domain-like	17	3
TPR-like	HSP20-like chaperones	17	4
GST C-terminal domain-like	eEF-1beta-like	17	4
Glutathione synthetase ATP-binding domain-like	SET domain	17	3
C2 domain (Calcium/lipid-binding domain, CaLB)	PH domain-like	16	5
RING/U-box	TRAF domain-like	16	5
Formate/glycerate dehydrogenase catalytic domain-like	Formate/glycerate dehydrogenase catalytic domain-like	16	2
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	16	4
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	16	6
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	16	2
PheT/TilS domain	Putative DNA-binding domain	16	4
Myosin rod fragments	Myosin rod fragments	16	10
2Fe-2S ferredoxin-like	Fe-only hydrogenase	16	4
PX domain	WD40 repeat-like	16	4
NAD(P)-binding Rossmann-fold domains	FabD/lysophospholipase-like	16	9
FMN-linked oxidoreductases	4Fe-4S ferredoxins	16	3
UBC-like	UBA-like	16	1
TRAF domain-like	POZ domain	16	4
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	16	4
Nucleotide cyclase	Protein kinase-like (PK-like)	16	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	16	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	16	6
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	16	9
ACP-like	FabD/lysophospholipase-like	16	9
E set domains	Protein kinase-like (PK-like)	16	2
Ferritin-like	Rubredoxin-like	16	1
TPR-like	Formin homology 2 domain (FH2 domain)	16	2
TPR-like	Protein kinase-like (PK-like)	16	9
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	16	3
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	16	2
FAD/NAD(P)-binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	16	4
Ankyrin repeat	Rap/Ran-GAP	16	2
Thiolase-like	FabD/lysophospholipase-like	16	9
(Trans)glycosidases	Six-hairpin glycosidases	16	3
DBL homology domain (DH-domain)	GTPase activation domain, GAP	16	4
FAD/NAD(P)-binding domain	Riboflavin synthase domain-like	15	3
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	15	5
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	15	3
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Riboflavin synthase domain-like	15	3
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	15	3
ALDH-like	Dehydroquinate synthase-like	15	1
SAICAR synthase-like	SAICAR synthase-like	15	5
FYVE/PHD zinc finger	Bromodomain	15	4
NTF2-like	RNA-binding domain, RBD	15	4
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	15	2
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	15	2
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	15	2
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	15	6
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	15	4
PX domain	Protein kinase-like (PK-like)	15	4
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	15	4
PheT/TilS domain	Class II aaRS and biotin synthetases	15	3
(Trans)glycosidases	(Trans)glycosidases	15	7
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	15	2
Zinc hairpin stack	RING/U-box	15	3
Actin-like ATPase domain	TPR-like	15	3
ADP-ribosylation	B-box zinc-binding domain	15	2
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	15	2
RNI-like	Calpain large subunit, middle domain (domain III)	15	5
Bromodomain	Bromodomain	15	4
Activator of Hsp90 ATPase, Aha1	Activator of Hsp90 ATPase, Aha1	15	2
Cysteine proteinases	UBA-like	15	2
GST C-terminal domain-like	Ribosomal protein L25-like	15	3
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	15	4
HMA, heavy metal-associated domain	HAD-like	15	8
DNase I-like	GTPase activation domain, GAP	14	3
ISP domain	FAD/NAD(P)-binding domain	14	5
Metalloproteases ("zincins"), catalytic domain	E set domains	14	2
BRCT domain	DNA/RNA polymerases	14	4
ARM repeat	BEACH domain	14	7
PapD-like	Protein kinase-like (PK-like)	14	2
"Winged helix" DNA-binding domain	39 kda initiator binding protein, IBP39, C-terminal domains	14	1
DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	14	3
SET domain	Ankyrin repeat	14	4
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	14	4
Protein kinase-like (PK-like)	SH2 domain	14	2
Barwin-like endoglucanases	Galactose-binding domain-like	14	3
Pectin lyase-like	RING/U-box	14	4
L domain-like	NTF2-like	14	4
Putative isomerase YbhE	WD40 repeat-like	14	7
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	14	8
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	14	4
WD40 repeat-like	Bromodomain	14	4
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	14	1
TSP-1 type 1 repeat	EGF/Laminin	14	3
alpha/beta knot	Nucleic acid-binding proteins	14	1
P-loop containing nucleoside triphosphate hydrolases	Ankyrin repeat	14	4
P-loop containing nucleoside triphosphate hydrolases	Concanavalin A-like lectins/glucanases	14	5
Trypsin-like serine proteases	PDZ domain-like	14	5
SNARE fusion complex	SNARE fusion complex	14	2
Ankyrin repeat	Arginase/deacetylase	14	3
Homodimeric domain of signal transducing histidine kinase	CheY-like	14	3
PH domain-like	PLC-like phosphodiesterases	14	4
NAD(P)-binding Rossmann-fold domains	Probable ACP-binding domain of malonyl-CoA ACP transacylase	14	8
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	14	3
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	14	3
ACP-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	14	8
Voltage-gated potassium channels	cAMP-binding domain-like	14	4
Nucleotide-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	14	2
Ubiquitin-like	Type III secretory system chaperone-like	14	3
WW domain	CCCH zinc finger	14	3
Kelch motif	Metallo-dependent phosphatases	14	4
Protein kinase-like (PK-like)	Ypt/Rab-GAP domain of gyp1p	14	4
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	14	3
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	13	2
UBC-like	Ribosomal protein S5 domain 2-like	13	2
Kelch motif	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	13	1
Sec1/munc18-like (SM) proteins	Sec1/munc18-like (SM) proteins	13	3
PsbU/PolX domain-like	Nucleotidyltransferase	13	5
Bromodomain	SET domain	13	4
alpha/beta-Hydrolases	Galactose-binding domain-like	13	3
SMAD/FHA domain	BRCT domain	13	2
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	13	4
ApbE-like	FAD/NAD(P)-binding domain	13	3
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	13	7
Six-hairpin glycosidases	HAD-like	13	5
P-loop containing nucleoside triphosphate hydrolases	DNA ligase/mRNA capping enzyme, catalytic domain	13	4
Homeodomain-like	CHY zinc finger-like	13	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	13	3
Thiolase-like	GroES-like	13	8
Ankyrin repeat	Phosphoglycerate mutase-like	13	3
Class I glutamine amidotransferase-like	Class I glutamine amidotransferase-like	13	3
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	13	2
ARM repeat	Concanavalin A-like lectins/glucanases	13	6
ACP-like	GroES-like	13	8
Retrovirus zinc finger-like domains	RING/U-box	13	2
CHY zinc finger-like	Zinc hairpin stack	13	2
Activating enzymes of the ubiquitin-like proteins	Rhodanese/Cell cycle control phosphatase	13	2
ACP-like	ACP-like	13	7
ARM repeat	Chaperone J-domain	13	8
Galactose oxidase, central domain	S-adenosyl-L-methionine-dependent methyltransferases	13	6
alpha/beta knot	alpha/beta knot	13	4
Class I glutamine amidotransferase-like	ADC synthase	13	2
BAR/IMD domain-like	PH domain-like	12	2
PUG domain-like	Ubiquitin-like	12	3
Acetyl-CoA synthetase-like	Thiolase-like	12	6
TPR-like	Cyclophilin-like	12	2
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	12	4
GTPase activation domain, GAP	RNI-like	12	2
GroES-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	12	7
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	12	1
Second domain of FERM	Second domain of FERM	12	5
TPR-like	RING/U-box	12	2
Tropomyosin	Ankyrin repeat	12	5
Tudor/PWWP/MBT	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	12	3
GTPase activation domain, GAP	WD40 repeat-like	12	1
Outer arm dynein light chain 1	(Phosphotyrosine protein) phosphatases II	12	2
ApbE-like	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	12	2
Nqo1 middle domain-like	Nqo1C-terminal domain-like	12	1
GTPase activation domain, GAP	Cysteine-rich domain	12	1
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	12	2
L domain-like	Ubiquitin-like	12	5
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	12	5
WW domain	C2 domain (Calcium/lipid-binding domain, CaLB)	12	2
Single hybrid motif	Single hybrid motif	12	6
RCC1/BLIP-II	Ras GEF	12	2
PH domain-like	L domain-like	12	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	12	3
Barwin-like endoglucanases	PHL pollen allergen	12	3
DNA/RNA polymerases	DNA/RNA polymerases	12	6
ApbE-like	Riboflavin synthase domain-like	12	2
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	12	1
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	12	3
RING/U-box	Hect, E3 ligase catalytic domain	12	6
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	12	1
DNA primase core	Ribonuclease H-like	12	3
FMN-linked oxidoreductases	FAD/NAD(P)-binding domain	12	3
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	12	3
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	12	4
RNI-like	cAMP-binding domain-like	12	5
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	12	4
UBC-like	P-loop containing nucleoside triphosphate hydrolases	12	3
ISP transmembrane anchor	ISP domain	12	1
Ubiquitin-like	Homeodomain-like	12	3
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	12	4
BAR/IMD domain-like	Ankyrin repeat	12	2
L30e-like	alpha/beta knot	12	3
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease H-like	12	3
P-loop containing nucleoside triphosphate hydrolases	dUTPase-like	12	1
ApbE-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	12	2
Ras GEF	GTPase activation domain, GAP	12	2
GroES-like	FabD/lysophospholipase-like	12	7
Nucleoporin domain	WD40 repeat-like	11	6
Class II aaRS and biotin synthetases	Class II aaRS and biotin synthetases	11	4
Kelch motif	P-loop containing nucleoside triphosphate hydrolases	11	4
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	11	4
Kelch motif	E set domains	11	4
Nucleotidylyl transferase	Alpha-L RNA-binding motif	11	2
SMAD/FHA domain	RNA-binding domain, RBD	11	4
FYVE/PHD zinc finger	ARM repeat	11	3
WGR domain-like	Domain of poly(ADP-ribose) polymerase	11	4
Oligoxyloglucan reducing end-specific cellobiohydrolase	Oligoxyloglucan reducing end-specific cellobiohydrolase	11	2
ARM repeat	Cysteine proteinases	11	4
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	11	3
PapD-like	P-loop containing nucleoside triphosphate hydrolases	11	4
Ribonuclease H-like	Nucleic acid-binding proteins	11	3
Protein kinase-like (PK-like)	beta-lactamase/transpeptidase-like	11	4
Voltage-gated potassium channels	Voltage-gated potassium channels	11	4
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	11	4
PUA domain-like	SET domain	11	2
GroEL apical domain-like	SAICAR synthase-like	11	5
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	11	6
WGR domain-like	ADP-ribosylation	11	4
Creatinase/aminopeptidase	Creatinase/aminopeptidase	11	2
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	11	3
WD40 repeat-like	Ribonuclease H-like	11	3
Arginase/deacetylase	SAICAR synthase-like	11	4
PR-1-like	PR-1-like	11	4
Smp-1-like	Smp-1-like	11	1
Cytochrome b5-like heme/steroid binding domain	Cytochrome b5-like heme/steroid binding domain	10	3
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	10	5
TRAF domain-like	Pseudouridine synthase	10	3
Concanavalin A-like lectins/glucanases	RING/U-box	10	6
PHL pollen allergen	Galactose-binding domain-like	10	2
Tudor/PWWP/MBT	Zinc beta-ribbon	10	1
Histone-fold	ARM repeat	10	1
WD40 repeat-like	Cysteine proteinases	10	2
FAD-linked reductases, C-terminal domain	FYVE/PHD zinc finger	10	4
CBS-domain pair	CBS-domain pair	10	3
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	10	4
PYP-like sensor domain (PAS domain)	CheY-like	10	3
Galactose oxidase, central domain	Metallo-dependent phosphatases	10	2
Mib/herc2 domain-like	Mib/herc2 domain-like	10	1
Anthrax protective antigen	Galactose-binding domain-like	10	3
YbiA-like	SMAD/FHA domain	10	3
F-box domain	RNI-like	10	3
RNI-like	WD40 repeat-like	10	7
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	10	4
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	10	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	10	3
YbiA-like	RNA-binding domain, RBD	10	3
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	10	2
Cysteine proteinases	Ribonuclease H-like	10	2
DNA primase core	DNA/RNA polymerases	10	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	10	5
RNA-binding domain, RBD	Tricorn protease domain 2	10	2
Acetyl-CoA synthetase-like	GroES-like	10	5
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	10	5
cAMP-binding domain-like	PYP-like sensor domain (PAS domain)	10	3
Acetyl-CoA synthetase-like	FabD/lysophospholipase-like	10	5
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	10	5
Acetyl-CoA synthetase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	10	5
TPR-like	RNA-binding domain, RBD	10	5
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	10	4
DPP6 N-terminal domain-like	Quinoprotein alcohol dehydrogenase-like	10	4
Metalloproteases ("zincins"), catalytic domain	4'-phosphopantetheinyl transferase	10	5
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	10	1
Myosin rod fragments	Ankyrin repeat	10	5
WWE domain	BRCT domain	10	2
BAG domain	HSP20-like chaperones	10	2
LDL receptor-like module	Mannose 6-phosphate receptor domain	10	3
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	10	6
Arginase/deacetylase	Arginase/deacetylase	10	3
DNA ligase/mRNA capping enzyme, catalytic domain	DNA ligase/mRNA capping enzyme, catalytic domain	10	2
Calponin-homology domain, CH-domain	Spectrin repeat	10	3
UBA-like	ADP-ribosylation	10	1
WD40 repeat-like	Tricorn protease N-terminal domain	10	4
P-loop containing nucleoside triphosphate hydrolases	UBA-like	10	4
alpha-helical ferredoxin	FAD/NAD(P)-binding domain	9	3
SAM/Pointed domain	P-loop containing nucleoside triphosphate hydrolases	9	1
TrmE connector domain	P-loop containing nucleoside triphosphate hydrolases	9	4
POZ domain	POZ domain	9	2
Cysteine proteinases	Glutathione synthetase ATP-binding domain-like	9	1
Bet v1-like	Bet v1-like	9	4
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	9	1
Ribokinase-like	Ribokinase-like	9	1
TGS-like	ThrRS/AlaRS common domain	9	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	9	3
C2 domain (Calcium/lipid-binding domain, CaLB)	Ankyrin repeat	9	2
TolB, C-terminal domain	WD40 repeat-like	9	5
TGS-like	Class II aaRS and biotin synthetases	9	2
P-loop containing nucleoside triphosphate hydrolases	beta-beta-alpha zinc fingers	9	4
CCCH zinc finger	Retrovirus zinc finger-like domains	9	3
Alpha subunit of glutamate synthase, C-terminal domain	FAD/NAD(P)-binding domain	9	3
Cysteine proteinases	PreATP-grasp domain	9	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	9	2
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	9	2
EF-hand	Quinoprotein alcohol dehydrogenase-like	9	6
(Trans)glycosidases	UDP-Glycosyltransferase/glycogen phosphorylase	9	4
E set domains	AMPKBI-like	9	2
beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	9	3
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	9	3
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	9	3
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	9	3
Macro domain-like	CRAL/TRIO domain	9	2
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	9	2
Sec7 domain	Ypt/Rab-GAP domain of gyp1p	9	1
TGS-like	Class II aaRS ABD-related	9	2
DNA-glycosylase	Nudix	9	4
Folate-binding domain	P-loop containing nucleoside triphosphate hydrolases	9	4
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	9	4
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	9	3
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	9	4
Bet v1-like	PH domain-like	9	4
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	9	4
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	9	5
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	9	3
S-adenosylmethionine decarboxylase	PLP-binding barrel	9	3
GST C-terminal domain-like	GST C-terminal domain-like	9	2
Invasin/intimin cell-adhesion fragments	Invasin/intimin cell-adhesion fragments	8	2
E set domains	C2 domain (Calcium/lipid-binding domain, CaLB)	8	1
Acetyl-CoA synthetase-like	Actin-like ATPase domain	8	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Cysteine proteinases	8	1
THUMP domain-like	Adenine nucleotide alpha hydrolases-like	8	2
Aldolase	post-HMGL domain-like	8	2
alpha-helical ferredoxin	4Fe-4S ferredoxins	8	2
L domain-like	VHP, Villin headpiece domain	8	1
Concanavalin A-like lectins/glucanases	Quinoprotein alcohol dehydrogenase-like	8	2
GTPase activation domain, GAP	VPS9 domain	8	2
4Fe-4S ferredoxins	Flavoproteins	8	4
Formyltransferase	FMT C-terminal domain-like	8	1
BEACH domain	NHL repeat	8	4
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	8	2
Protein kinase-like (PK-like)	SH3-domain	8	2
S-adenosylmethionine decarboxylase	Alanine racemase C-terminal domain-like	8	2
Nucleotide-binding domain	4Fe-4S ferredoxins	8	2
4Fe-4S ferredoxins	Ferredoxin reductase-like, C-terminal NADP-linked domain	8	4
Nucleic acid-binding proteins	Translation proteins	8	3
SMAD/FHA domain	FKBP-like	8	2
FAD/NAD(P)-binding domain	FYVE/PHD zinc finger	8	3
Kringle-like	Growth factor receptor domain	8	6
RNI-like	Ubiquitin-like	8	5
DBL homology domain (DH-domain)	Ras GEF	8	1
Protein kinase-like (PK-like)	RING/U-box	8	4
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	8	3
post-HMGL domain-like	Single hybrid motif	8	2
Ricin B-like lectins	RPA2825-like	8	1
4Fe-4S ferredoxins	Riboflavin synthase domain-like	8	4
Acid proteases	UBA-like	8	2
EF-hand	Inorganic pyrophosphatase	8	2
Nucleic acid-binding proteins	Initiation factor IF2/eIF5b, domain 3	8	3
cAMP-binding domain-like	EF-hand	8	6
Eukaryotic type KH-domain (KH-domain type I)	SMR domain-like	8	2
Oxysterol-binding protein-like	Oxysterol-binding protein-like	8	4
PH domain-like	I/LWEQ domain	8	1
BEACH domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	8	4
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	8	3
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	8	1
Folate-binding domain	TrmE connector domain	8	3
E set domains	WW domain	8	1
Duffy binding domain-like	Adhesin YadA, collagen-binding domain	8	4
L domain-like	Growth factor receptor domain	8	3
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	8	2
PX domain	PH domain-like	8	1
FYVE/PHD zinc finger	GroEL apical domain-like	8	5
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	8	2
Calponin-homology domain, CH-domain	E set domains	8	3
Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8	4
CheY-like	Protein kinase-like (PK-like)	8	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Rap/Ran-GAP	8	3
GTPase activation domain, GAP	Ankyrin repeat	8	2
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	8	6
Glutamine synthetase/guanido kinase	GatB/YqeY motif	8	3
DPP6 N-terminal domain-like	GYF domain	8	1
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	8	4
PH domain-like	SH3-domain	8	2
DNase I-like	Actin-like ATPase domain	8	2
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	8	3
Second domain of FERM	RNI-like	8	4
Ankyrin repeat	ARM repeat	8	3
PspA lactotransferrin-binding region	PspA lactotransferrin-binding region	8	4
DNase I-like	Acetyl-CoA synthetase-like	8	2
Second domain of FERM	I/LWEQ domain	8	1
Protein kinase-like (PK-like)	Pectin lyase-like	8	4
FAD/NAD(P)-binding domain	CPE0013-like	8	3
Arp2/3 complex subunits	Arp2/3 complex subunits	8	1
"Winged helix" DNA-binding domain	HRDC-like	8	1
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	8	2
Nucleotidylyl transferase	tRNA-binding arm	8	2
Phage fibre proteins	Phage fibre proteins	8	4
4Fe-4S ferredoxins	FMN-dependent nitroreductase-like	8	1
RCC1/BLIP-II	DBL homology domain (DH-domain)	8	1
Spectrin repeat	EF-hand	8	2
alpha/beta-Hydrolases	SAM/Pointed domain	8	2
C-type lectin-like	S-adenosyl-L-methionine-dependent methyltransferases	8	1
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	8	4
Second domain of FERM	PH domain-like	8	1
P-loop containing nucleoside triphosphate hydrolases	C2 domain (Calcium/lipid-binding domain, CaLB)	8	2
L domain-like	Actin depolymerizing proteins	8	1
Aldolase	Single hybrid motif	8	2
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	7	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Caspase-like	7	3
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	7	2
SSo0622-like	S-adenosyl-L-methionine-dependent methyltransferases	7	3
HAD-like	AF1104-like	7	1
Trypsin-like serine proteases	ARM repeat	7	2
F-box domain	P-loop containing nucleoside triphosphate hydrolases	7	5
Fibronectin type III	Fibronectin type III	7	6
EPT/RTPC-like	EPT/RTPC-like	7	2
WWE domain	RING/U-box	7	1
Pectin lyase-like	Formin homology 2 domain (FH2 domain)	7	3
Starch-binding domain-like	EF-hand	7	1
P-loop containing nucleoside triphosphate hydrolases	Calpain large subunit, middle domain (domain III)	7	1
Ribonuclease H-like	Retrovirus zinc finger-like domains	7	2
Ribulose-phoshate binding barrel	PRTase-like	7	1
Tex N-terminal region-like	Ribonuclease H-like	7	3
Ankyrin repeat	alpha/beta-Hydrolases	7	1
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	7	2
ISP domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	7	2
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	7	3
Ankyrin repeat	Complement control module/SCR domain	7	2
Chaperone J-domain	Chaperone J-domain	7	2
PH domain-like	"Winged helix" DNA-binding domain	7	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	7	1
DNA ligase/mRNA capping enzyme, catalytic domain	S-adenosyl-L-methionine-dependent methyltransferases	7	2
FKBP-like	FKBP-like	7	2
Tex N-terminal region-like	RuvA domain 2-like	7	3
Glutathione synthetase ATP-binding domain-like	Argininosuccinate synthetase, C-terminal domain	7	3
Activator of Hsp90 ATPase, Aha1	Bet v1-like	7	1
Concanavalin A-like lectins/glucanases	Amine oxidase catalytic domain	7	2
UBA-like	SMR domain-like	7	2
Ran binding protein zinc finger-like	RING/U-box	7	2
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	7	3
Carbamate kinase-like	PUA domain-like	7	2
Ricin B-like lectins	Concanavalin A-like lectins/glucanases	7	3
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FAD/NAD(P)-binding domain	7	2
Ribonuclease H-like	RuvA domain 2-like	7	3
SPOC domain-like	C-terminal domain of Ku80	7	3
Acetyl-CoA synthetase-like	DHS-like NAD/FAD-binding domain	7	3
Glutathione synthetase ATP-binding domain-like	Adenine nucleotide alpha hydrolases-like	7	3
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Nucleotide-binding domain	7	2
PH domain-like	Quinoprotein alcohol dehydrogenase-like	7	2
ARM repeat	Calpain large subunit, middle domain (domain III)	7	1
TPR-like	PDZ domain-like	7	2
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	7	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	FYVE/PHD zinc finger	7	2
RNA-binding domain, RBD	HAND domain of the nucleosome remodeling ATPase ISWI	7	2
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	7	1
Ran binding protein zinc finger-like	RNA-binding domain, RBD	7	1
Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclases/Protein prenyltransferases	7	1
Starch-binding domain-like	Protein kinase-like (PK-like)	7	1
Calcium ATPase, transmembrane domain M	Calcium ATPase, transmembrane domain M	7	4
RuvA domain 2-like	RuvA domain 2-like	7	3
FumA C-terminal domain-like	FumA C-terminal domain-like	7	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	7	4
NHL repeat	WD40 repeat-like	7	4
ISP domain	Riboflavin synthase domain-like	7	2
Mannose 6-phosphate receptor domain	YccV-like	7	2
Methylglyoxal synthase-like	Argininosuccinate synthetase, C-terminal domain	7	3
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	7	2
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	7	3
Oligoxyloglucan reducing end-specific cellobiohydrolase	Sialidases	7	2
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	7	3
Cap-Gly domain	L domain-like	7	4
Acetyl-CoA synthetase-like	Thiamin diphosphate-binding fold (THDP-binding)	7	3
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	7	2
Plus3-like	RING/U-box	7	1
Methylglyoxal synthase-like	Adenine nucleotide alpha hydrolases-like	7	3
ENTH/VHS domain	GAT-like domain	7	2
CCCH zinc finger	WD40 repeat-like	7	2
SSo0622-like	Galactose oxidase, central domain	7	3
vWA-like	C-terminal domain of Ku80	7	3
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	7	3
YjeF N-terminal domain-like	Ribokinase-like	7	1
WWE domain	WD40 repeat-like	7	2
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	7	2
RING/U-box	R3H domain	6	1
ENTH/VHS domain	P-loop containing nucleoside triphosphate hydrolases	6	2
Dihydrofolate reductase-like	RmlC-like cupins	6	1
Flavoproteins	Rubredoxin-like	6	1
GTPase activation domain, GAP	(Phosphotyrosine protein) phosphatases II	6	2
Rhodanese/Cell cycle control phosphatase	FKBP-like	6	1
RNA-binding domain, RBD	PWI domain	6	2
L domain-like	DNase I-like	6	1
E set domains	Six-hairpin glycosidases	6	2
PH domain-like	Cysteine proteinases	6	2
POZ domain	Galactose oxidase, central domain	6	4
vWA-like	UBC-like	6	2
RING/U-box	L domain-like	6	4
RING/U-box	Cyclophilin-like	6	2
alpha/beta-Hydrolases	P-loop containing nucleoside triphosphate hydrolases	6	2
Chondroitin AC/alginate lyase	Galactose mutarotase-like	6	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	6	2
Clc chloride channel	TrkA C-terminal domain-like	6	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	Quinoprotein alcohol dehydrogenase-like	6	3
Flavoproteins	FAD/NAD(P)-binding domain	6	1
Protein kinase-like (PK-like)	Cap-Gly domain	6	1
POZ domain	Concanavalin A-like lectins/glucanases	6	1
Gamma-glutamyl cyclotransferase-like	Alkaline phosphatase-like	6	2
RNI-like	CCCH zinc finger	6	1
PDZ domain-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	6	2
P-loop containing nucleoside triphosphate hydrolases	L domain-like	6	3
F-box domain	Clavaminate synthase-like	6	3
UBC-like	ADP-ribosylation	6	1
RNA-binding domain, RBD	ENTH/VHS domain	6	2
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	6	2
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	6	2
TRAF domain-like	TRAF domain-like	6	2
ARM repeat	HIT/MYND zinc finger-like	6	3
FYSH domain	EF-G C-terminal domain-like	6	1
RNI-like	PP2C-like	6	2
Cupredoxins	Cupredoxins	6	2
RmlC-like cupins	NAD(P)-binding Rossmann-fold domains	6	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	6	1
PDZ domain-like	Protein kinase-like (PK-like)	6	2
ClpP/crotonase	post-HMGL domain-like	6	1
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	6	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	6	2
RmlC-like cupins	Thioredoxin-like	6	1
Acyl-CoA binding protein	Acyl-CoA binding protein	6	2
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	6	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	6	2
FYVE/PHD zinc finger	HD-domain/PDEase-like	6	1
PLP-dependent transferases	MOSC N-terminal domain-like	6	3
Plus3-like	Metallo-dependent phosphatases	6	1
Porins	Porins	6	2
GTPase activation domain, GAP	Protein kinase-like (PK-like)	6	2
Hypothetical protein AF0491, middle domain	EF-G C-terminal domain-like	6	1
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	6	2
F-box domain	Quinoprotein alcohol dehydrogenase-like	6	2
alpha/beta-Hydrolases	UBC-like	6	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	6	2
Thioredoxin-like	RING/U-box	6	1
Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	6	3
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	6	2
Zn-dependent exopeptidases	Zn-dependent exopeptidases	6	2
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	6	3
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	6	2
Cytidine deaminase-like	Cytidine deaminase-like	6	1
NagB/RpiA/CoA transferase-like	LmbE-like	6	2
PX domain	FYVE/PHD zinc finger	6	2
PreATP-grasp domain	Argininosuccinate synthetase, C-terminal domain	6	2
TPR-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	6	4
L domain-like	EF-hand	6	3
ENTH/VHS domain	I/LWEQ domain	6	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	6	2
PUA domain-like	Nucleotidylyl transferase	6	2
ARM repeat	PDZ domain-like	6	2
DAK1/DegV-like	DhaL-like	6	2
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	6	1
POZ domain	RCC1/BLIP-II	6	4
Carbamoyl phosphate synthetase, large subunit connection domain	Argininosuccinate synthetase, C-terminal domain	6	2
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	6	2
EF-hand	FAD-linked oxidoreductase	6	1
Carbamoyl phosphate synthetase, large subunit connection domain	Adenine nucleotide alpha hydrolases-like	6	2
YWTD domain	Growth factor receptor domain	6	3
YVTN repeat-like/Quinoprotein amine dehydrogenase	RING/U-box	6	4
PreATP-grasp domain	Adenine nucleotide alpha hydrolases-like	6	2
BEACH domain	BEACH domain	6	3
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	6	2
GTPase activation domain, GAP	L domain-like	6	2
P-loop containing nucleoside triphosphate hydrolases	TRAF domain-like	6	3
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	6	2
PapD-like	PapD-like	6	3
Ubiquitin-like	E set domains	6	1
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	6	2
Type III secretory system chaperone-like	PDZ domain-like	6	3
AttH-like	Terpenoid synthases	6	1
PYP-like sensor domain (PAS domain)	Phosphoglycerate kinase	6	1
S-adenosyl-L-methionine-dependent methyltransferases	FAD/NAD(P)-binding domain	6	2
Protein prenylyltransferase	Outer arm dynein light chain 1	6	2
Ribonuclease H-like	ADP-ribosylation	6	2
WD40 repeat-like	PDZ domain-like	6	2
HCP-like	Ankyrin repeat	6	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	6	2
Metallo-hydrolase/oxidoreductase	FAD/NAD(P)-binding domain	6	1
Voltage-gated potassium channels	E set domains	6	2
WD40 repeat-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	6	2
Outer arm dynein light chain 1	E set domains	6	1
Saposin	Saposin	6	3
cAMP-binding domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	6	4
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	6	2
Galactose mutarotase-like	HAD-like	6	3
Galactose mutarotase-like	Six-hairpin glycosidases	6	3
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	6	2
PH domain-like	Homeodomain-like	6	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	6	2
Anthrax protective antigen	Concanavalin A-like lectins/glucanases	6	3
UBC-like	Retrovirus zinc finger-like domains	6	1
S-adenosyl-L-methionine-dependent methyltransferases	Clavaminate synthase-like	6	3
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	6	2
PH domain-like	Galactose oxidase, central domain	6	3
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	6	2
Ran binding protein zinc finger-like	FYVE/PHD zinc finger	6	2
Cap-Gly domain	RNI-like	6	3
ClpP/crotonase	Aldolase	6	1
Hsp33 domain	HSP33 redox switch-like	6	2
CCCH zinc finger	P-loop containing nucleoside triphosphate hydrolases	6	2
RNA-binding domain, RBD	Homeodomain-like	6	1
Rubredoxin-like	FAD/NAD(P)-binding domain	6	1
Calponin-homology domain, CH-domain	HCP-like	6	2
Metallo-hydrolase/oxidoreductase	Rubredoxin-like	6	1
Rhodanese/Cell cycle control phosphatase	S-adenosyl-L-methionine-dependent methyltransferases	5	2
HMG-box	Histone-fold	5	1
RNA-binding domain, RBD	Clavaminate synthase-like	5	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Adenine nucleotide alpha hydrolases-like	5	1
Starch-binding domain-like	UDP-Glycosyltransferase/glycogen phosphorylase	5	3
TSP-1 type 1 repeat	Kringle-like	5	2
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	5	2
SWIB/MDM2 domain	eIF1-like	5	1
VC0467-like	VC0467-like	5	2
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	5	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	4
Cysteine proteinases	Growth factor receptor domain	5	3
NAD(P)-linked oxidoreductase	NAD(P)-linked oxidoreductase	5	2
Periplasmic binding protein-like II	Periplasmic binding protein-like II	5	2
HMG-box	Homeodomain-like	5	1
P-loop containing nucleoside triphosphate hydrolases	Ran binding protein zinc finger-like	5	2
TRAF domain-like	ARM repeat	5	2
Starch-binding domain-like	HAD-like	5	3
WD40 repeat-like	Ypt/Rab-GAP domain of gyp1p	5	2
Galactose oxidase, central domain	Clavaminate synthase-like	5	2
Class I glutamine amidotransferase-like	Argininosuccinate synthetase, C-terminal domain	5	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	Quinoprotein alcohol dehydrogenase-like	5	1
Chromo domain-like	Bromodomain	5	2
CCCH zinc finger	Chaperone J-domain	5	2
Growth factor receptor domain	Hairpin loop containing domain-like	5	3
Quinoprotein alcohol dehydrogenase-like	ARM repeat	5	3
Trypsin-like serine proteases	P-loop containing nucleoside triphosphate hydrolases	5	1
RNI-like	Quinoprotein alcohol dehydrogenase-like	5	2
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	5	3
Creatinase/aminopeptidase	PH domain-like	5	2
Ubiquitin-like	PDZ domain-like	5	2
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	5	2
FKBP-like	Cyclophilin-like	5	1
Outer arm dynein light chain 1	Outer arm dynein light chain 1	5	3
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	3
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	5	1
UROD/MetE-like	UROD/MetE-like	5	1
Metal cation-transporting ATPase, ATP-binding domain N	Nucleotide cyclase	5	2
TPR-like	P-loop containing nucleoside triphosphate hydrolases	5	2
BB1717-like	BB1717-like	5	2
RNI-like	Hemopexin-like domain	5	1
RCC1/BLIP-II	Chromo domain-like	5	1
EGF/Laminin	Hairpin loop containing domain-like	5	3
Type II DNA topoisomerase	Type II DNA topoisomerase	5	2
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	5	1
Integrin alpha N-terminal domain	Integrin alpha N-terminal domain	5	3
Protein kinase-like (PK-like)	Hect, E3 ligase catalytic domain	5	2
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	5	1
Calponin-homology domain, CH-domain	Tropomyosin	5	2
FMN-linked oxidoreductases	FMN-linked oxidoreductases	5	2
Folate-binding domain	Folate-binding domain	5	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Argininosuccinate synthetase, C-terminal domain	5	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	5	1
Metallo-hydrolase/oxidoreductase	Rhodanese/Cell cycle control phosphatase	5	2
Class II aaRS ABD-related	Class II aaRS ABD-related	5	1
UDP-Glycosyltransferase/glycogen phosphorylase	Glycosyl hydrolase domain	5	2
Hypothetical protein AF0491, middle domain	beta-beta-alpha zinc fingers	5	2
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	5	3
NAD(P)-binding Rossmann-fold domains	ACT-like	5	3
Clavaminate synthase-like	Clavaminate synthase-like	5	2
FYVE/PHD zinc finger	F-box domain	5	4
RNI-like	Ankyrin repeat	5	2
MFS general substrate transporter	Multidrug resistance efflux transporter EmrE	5	3
PUA domain-like	SWIB/MDM2 domain	5	1
Galactose oxidase, central domain	Galactose oxidase, central domain	5	1
R3H domain	P-loop containing nucleoside triphosphate hydrolases	5	3
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	5	1
DBL homology domain (DH-domain)	VHP, Villin headpiece domain	4	1
RNase III domain-like	RNase III domain-like	4	2
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Enolase N-terminal domain-like	4	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Riboflavin synthase domain-like	4	2
GroEL-intermediate domain like	GroEL-intermediate domain like	4	2
Tudor/PWWP/MBT	YaeB-like	4	2
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	RNA-binding domain, RBD	4	1
Protein kinase-like (PK-like)	Tropomyosin	4	2
Cap-Gly domain	EF-hand	4	2
DPP6 N-terminal domain-like	RING/U-box	4	2
RING/U-box	DHS-like NAD/FAD-binding domain	4	1
TNF receptor-like	Growth factor receptor domain	4	3
PH domain-like	VHP, Villin headpiece domain	4	2
E set domains	Integrin alpha N-terminal domain	4	1
Growth factor receptor domain	Pectin lyase-like	4	2
ARM repeat	Tropomyosin	4	2
Agglutinin HPA-like	Rap/Ran-GAP	4	1
Galactose-binding domain-like	CalX-like	4	2
Indigoidine synthase A-like	Ribokinase-like	4	1
(Trans)glycosidases	Growth factor receptor domain	4	2
TK C-terminal domain-like	Riboflavin synthase domain-like	4	2
L domain-like	WD40 repeat-like	4	1
Growth factor receptor domain	Calcium ATPase, transmembrane domain M	4	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	4	2
PH domain-like	NHL repeat	4	2
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	4	1
L domain-like	UBA-like	4	2
HAD-like	CCCH zinc finger	4	2
Dimeric alpha+beta barrel	MCP/YpsA-like	4	1
SAICAR synthase-like	Phosphoglycerate mutase-like	4	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	4	1
RING/U-box	NHL repeat	4	2
Ankyrin repeat	DBL homology domain (DH-domain)	4	2
Ran binding protein zinc finger-like	Concanavalin A-like lectins/glucanases	4	2
WD40 repeat-like	VHP, Villin headpiece domain	4	2
MIT domain	Glucocorticoid receptor-like (DNA-binding domain)	4	1
WD40 repeat-like	HCP-like	4	2
CYTH-like phosphatases	DNA ligase/mRNA capping enzyme, catalytic domain	4	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	4	1
ENTH/VHS domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	4	1
Methionine synthase domain	Methionine synthase activation domain-like	4	1
Nucleotide-diphospho-sugar transferases	Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain	4	1
F-box domain	Kelch motif	4	2
Cytochrome c oxidase subunit I-like	Transmembrane di-heme cytochromes	4	2
Globin-like	Riboflavin synthase domain-like	4	1
Outer membrane lipoprotein	Ankyrin repeat	4	1
Calcium-dependent phosphotriesterase	WD40 repeat-like	4	3
DBL homology domain (DH-domain)	Glucocorticoid receptor-like (DNA-binding domain)	4	1
B-box zinc-binding domain	HCP-like	4	1
GTPase activation domain, GAP	RGC domain-like	4	1
GTPase activation domain, GAP	Glucocorticoid receptor-like (DNA-binding domain)	4	1
Nucleotide cyclase	Smp-1-like	4	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	4	1
ENTH/VHS domain	Ran binding protein zinc finger-like	4	1
PDZ domain-like	PDZ domain-like	4	1
RNA-binding domain, RBD	HIT-like	4	2
MIT domain	MIT domain	4	1
CYTH-like phosphatases	Nucleic acid-binding proteins	4	1
DNase I-like	PapD-like	4	2
TPR-like	SGNH hydrolase	4	2
WD40 repeat-like	Actin depolymerizing proteins	4	2
Protein kinase-like (PK-like)	Calpain large subunit, middle domain (domain III)	4	1
CCCH zinc finger	ARM repeat	4	1
Putative isomerase YbhE	Quinoprotein alcohol dehydrogenase-like	4	2
Sec7 domain	HIT/MYND zinc finger-like	4	2
C-terminal domain of adenylylcyclase associated protein	Formin homology 2 domain (FH2 domain)	4	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Enolase C-terminal domain-like	4	1
Fe-only hydrogenase	Riboflavin synthase domain-like	4	2
Thiamin diphosphate-binding fold (THDP-binding)	Flavoproteins	4	2
Purine and uridine phosphorylases	Purine and uridine phosphorylases	4	2
MIT domain	Cysteine proteinases	4	2
Calponin-homology domain, CH-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	4	2
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	4	1
L domain-like	ADP-ribosylglycohydrolase	4	2
DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	4	2
WWE domain	WWE domain	4	1
Multiheme cytochromes	Growth factor receptor domain	4	2
Release factor	Release factor	4	2
(Trans)glycosidases	Chitinase insertion domain	4	1
Cysteine-rich domain	Hect, E3 ligase catalytic domain	4	1
Ankyrin repeat	E set domains	4	2
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	4	1
Bacterial hemolysins	Ankyrin repeat	4	2
2Fe-2S ferredoxin-like	Riboflavin synthase domain-like	4	2
Fe-only hydrogenase	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	2
Ankyrin repeat	SH3-domain	4	1
WD40 repeat-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	4	2
SAP domain	FYVE/PHD zinc finger	4	1
Protein kinase-like (PK-like)	ENTH/VHS domain	4	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	4	2
Methyl-accepting chemotaxis protein (MCP) signaling domain	I/LWEQ domain	4	1
TPR-like	NAD(P)-binding Rossmann-fold domains	4	2
Flavoproteins	Flavoproteins	4	2
PH domain-like	Actin depolymerizing proteins	4	2
Ran binding protein zinc finger-like	Hect, E3 ligase catalytic domain	4	2
THUMP domain-like	PLP-dependent transferases	4	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	4	1
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	4	1
Doublecortin (DC)	Doublecortin (DC)	4	1
(Phosphotyrosine protein) phosphatases II	Actin depolymerizing proteins	4	1
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	4	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	4	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	4	2
Aldolase	Aldolase	4	2
Acetyl-CoA synthetase-like	Ankyrin repeat	4	1
RNA-binding domain, RBD	alpha/beta knot	4	1
TK C-terminal domain-like	Flavoproteins	4	2
Globin-like	Globin-like	4	1
PAH2 domain	PAH2 domain	4	1
RING/U-box	F-box domain	4	1
cAMP-binding domain-like	CheY-like	4	1
WW domain	FKBP-like	4	1
Globin-like	Nucleotide cyclase	4	1
Concanavalin A-like lectins/glucanases	NHL repeat	4	2
Chaperone J-domain	L domain-like	4	1
R3H domain	Ribonuclease H-like	4	1
RNI-like	TPR-like	4	2
L domain-like	Ankyrin repeat	4	2
E set domains	UDP-Glycosyltransferase/glycogen phosphorylase	4	2
Lipovitellin-phosvitin complex, superhelical domain	Sec7 domain	4	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	1
Bet v1-like	Oxysterol-binding protein-like	4	2
ARM repeat	RNI-like	4	2
HIT/MYND zinc finger-like	CCCH zinc finger	4	1
WD40 repeat-like	Nitrous oxide reductase, N-terminal domain	4	2
POZ domain	Class I glutamine amidotransferase-like	4	1
TPR-like	Hect, E3 ligase catalytic domain	4	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	4	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	alpha-helical ferredoxin	4	1
Fe-only hydrogenase	Flavoproteins	4	2
ADP-ribosylation	ADP-ribosylation	4	2
Carbohydrate phosphatase	Carbohydrate phosphatase	4	1
2Fe-2S ferredoxin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	2
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	4	1
Kringle-like	TNF receptor-like	4	3
P-loop containing nucleoside triphosphate hydrolases	SH3-domain	4	1
Dehydroquinate synthase-like	Dehydroquinate synthase-like	4	2
TK C-terminal domain-like	alpha-helical ferredoxin	4	1
Homocysteine S-methyltransferase	Methionine synthase domain	4	1
SpoIIaa-like	Phosphoglycerate mutase-like	4	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Flavoproteins	4	2
E set domains	Actin-like ATPase domain	4	1
POZ domain	Bromodomain	4	1
PLC-like phosphodiesterases	PLC-like phosphodiesterases	4	2
Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	4	1
Macro domain-like	DHS-like NAD/FAD-binding domain	4	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	4	1
Dihydropteroate synthetase-like	Methionine synthase domain	4	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	4	1
FYVE/PHD zinc finger	SAICAR synthase-like	4	2
Thiamin diphosphate-binding fold (THDP-binding)	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	2
Cytochrome b5-like heme/steroid binding domain	Ubiquitin-like	4	1
WW domain	ARM repeat	4	1
Nudix	Nudix	4	1
Chaperone J-domain	Phage fibre proteins	4	2
Amidase signature (AS) enzymes	Amidase signature (AS) enzymes	4	2
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	4	1
Chorismate synthase, AroC	Chorismate synthase, AroC	4	2
Ran binding protein zinc finger-like	Cysteine proteinases	4	2
TK C-terminal domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	2
LDL receptor-like module	LDL receptor-like module	4	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	2
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	4	1
Cap-Gly domain	Metallo-dependent phosphatases	4	2
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	4	1
GIY-YIG endonuclease	RING/U-box	4	1
TROVE domain-like	WD40 repeat-like	4	2
vWA-like	RING/U-box	4	1
ATP12-like	ATP12-like	4	2
Ribonuclease H-like	CCCH zinc finger	4	1
2Fe-2S ferredoxin-like	Flavoproteins	4	2
Terpenoid cyclases/Protein prenyltransferases	Cytochrome c oxidase subunit II-like, transmembrane region	4	2
Ankyrin repeat	POZ domain	4	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	Concanavalin A-like lectins/glucanases	4	3
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	4	1
Actin depolymerizing proteins	SH3-domain	4	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	4	1
Calponin-homology domain, CH-domain	VHP, Villin headpiece domain	4	1
Sec7 domain	Sec7 domain	4	2
3-carboxy-cis,cis-mucoante lactonizing enzyme	Protein kinase-like (PK-like)	4	1
WD40 repeat-like	BRCT domain	4	1
Agglutinin HPA-like	Ankyrin repeat	4	1
B-box zinc-binding domain	TRAF domain-like	4	2
Bacterial fluorinating enzyme, N-terminal domain	Bacterial fluorinating enzyme, C-terminal domain	4	1
CalX-like	CalX-like	4	2
Thiamin diphosphate-binding fold (THDP-binding)	Riboflavin synthase domain-like	4	2
Translation proteins SH3-like domain	Translation proteins SH3-like domain	4	1
Tricorn protease domain 2	TPR-like	4	2
CBS-domain pair	DHH phosphoesterases	4	1
Thiamin diphosphate-binding fold (THDP-binding)	alpha-helical ferredoxin	4	1
DEK C-terminal domain	HMG-box	4	1
Globin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	1
MIT domain	Calpain large subunit, middle domain (domain III)	4	2
PUG domain-like	UBC-like	4	1
(Trans)glycosidases	CalX-like	4	2
RING/U-box	ADP-ribosylation	4	1
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	4	3
UBA-like	Thioredoxin-like	4	1
DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	4	1
Protein kinase-like (PK-like)	Rhodanese/Cell cycle control phosphatase	4	2
NTF2-like	UBA-like	4	2
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	4	1
CCCH zinc finger	Eukaryotic type KH-domain (KH-domain type I)	4	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	4	1
ARM repeat	Pentapeptide repeat-like	3	3
PUG domain-like	PUG domain-like	3	1
"Winged helix" DNA-binding domain	Zinc beta-ribbon	3	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Microbial and mitochondrial ADK, insert "zinc finger" domain	3	1
FAD/NAD(P)-binding domain	Cytochrome b5-like heme/steroid binding domain	3	1
Transcription factor IIA (TFIIA), beta-barrel domain	FAD/NAD(P)-binding domain	3	1
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	3	2
Kringle-like	Calcium ATPase, transmembrane domain M	3	2
Aldolase	EF-hand	3	1
ARM repeat	GroEL equatorial domain-like	3	2
TROVE domain-like	P-loop containing nucleoside triphosphate hydrolases	3	1
P-loop containing nucleoside triphosphate hydrolases	Probable GTPase Der, C-terminal domain	3	2
PX domain	BAR/IMD domain-like	3	1
RNA-binding domain, RBD	WD40 repeat-like	3	2
Metallo-dependent phosphatases	Concanavalin A-like lectins/glucanases	3	1
Hook domain	Tropomyosin	3	1
FYSH domain	beta-beta-alpha zinc fingers	3	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	YVTN repeat-like/Quinoprotein amine dehydrogenase	3	2
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	3	1
Cap-Gly domain	P-loop containing nucleoside triphosphate hydrolases	3	1
Ubiquitin-like	Ran binding protein zinc finger-like	3	1
Tricorn protease domain 2	YVTN repeat-like/Quinoprotein amine dehydrogenase	3	2
PUG domain-like	(Trans)glycosidases	3	2
Cullin repeat-like	Cullin repeat-like	3	1
L9 N-domain-like	Ribonuclease H-like	3	1
YaeB-like	YaeB-like	3	1
ARM repeat	Multidrug efflux transporter AcrB transmembrane domain	3	1
Pentapeptide repeat-like	FYVE/PHD zinc finger	3	2
Subunits of heterodimeric actin filament capping protein Capz	WW domain	3	1
TPR-like	Retrovirus zinc finger-like domains	3	1
Riboflavin synthase domain-like	alpha-helical ferredoxin	3	1
MIR domain	MIR domain	3	1
TROVE domain-like	TROVE domain-like	3	1
Ricin B-like lectins	Anthrax protective antigen	3	2
RNI-like	Adenine nucleotide alpha hydrolases-like	3	1
Metallo-dependent phosphatases	Arabinanase/levansucrase/invertase	3	1
RING/U-box	Calcium-dependent phosphotriesterase	3	2
PX domain	PX domain	3	2
P-loop containing nucleoside triphosphate hydrolases	Methyl-accepting chemotaxis protein (MCP) signaling domain	3	1
Pseudouridine synthase	ARM repeat	3	1
Phage fibre proteins	PP2C-like	3	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Cytochrome b5-like heme/steroid binding domain	3	1
Galactose-binding domain-like	Spermadhesin, CUB domain	3	1
EF-hand	Tropomyosin	3	1
Alanine racemase C-terminal domain-like	Alanine racemase C-terminal domain-like	3	1
Staphylococcal nuclease	Ada DNA repair protein, N-terminal domain (N-Ada 10)	3	1
PAZ domain	Trimeric LpxA-like enzymes	3	2
Quinoprotein alcohol dehydrogenase-like	Tricorn protease domain 2	3	2
Tricorn protease N-terminal domain	TPR-like	3	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	alpha-helical ferredoxin	3	1
Riboflavin synthase domain-like	Nucleotide-binding domain	3	1
Cap-Gly domain	CRAL/TRIO domain	3	1
BEACH domain	Soluble quinoprotein glucose dehydrogenase	3	2
ENTH/VHS domain	ARM repeat	3	1
P-loop containing nucleoside triphosphate hydrolases	ACP-like	3	2
Cap-Gly domain	CRAL/TRIO N-terminal domain	3	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	Nucleotide-binding domain	3	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	3	2
Subtilisin-like	Spermadhesin, CUB domain	3	1
Nucleic acid-binding proteins	WWE domain	3	1
Insert subdomain of RNA polymerase alpha subunit	Insert subdomain of RNA polymerase alpha subunit	3	2
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	3	1
(Phosphotyrosine protein) phosphatases II	PUG domain-like	3	1
Acid proteases	Acid proteases	3	1
CYTH-like phosphatases	CYTH-like phosphatases	3	1
beta-sandwich domain of Sec23/24	Cysteine proteinases	3	2
Saposin	SGNH hydrolase	3	1
Nucleotide-binding domain	Nucleotide-binding domain	3	1
RNI-like	EF-hand	3	1
CYTH-like phosphatases	S-adenosyl-L-methionine-dependent methyltransferases	3	1
FYVE/PHD zinc finger	alpha/beta-Hydrolases	3	1
TPR-like	EGF/Laminin	3	2
Nucleotidylyl transferase	P-loop containing nucleoside triphosphate hydrolases	3	2
Methyl-accepting chemotaxis protein (MCP) signaling domain	Zn-dependent exopeptidases	3	1
Trimeric LpxA-like enzymes	HAD-like	3	1
HAD-like	Protein kinase-like (PK-like)	3	1
Quinoprotein alcohol dehydrogenase-like	Integrin alpha N-terminal domain	3	2
Periplasmic binding protein-like I	Smp-1-like	3	1
Cap-Gly domain	ABC transporter transmembrane region	3	1
Glycerate kinase I	Glycerate kinase I	3	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	DPP6 N-terminal domain-like	3	2
SufE/NifU	Adenine nucleotide alpha hydrolases-like	3	1
SSo0622-like	Kelch motif	2	1
EF-hand	ARM repeat	2	1
Acid proteases	DNA/RNA polymerases	2	2
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	2	1
Ubiquitin-like	HAD-like	2	1
Actin-like ATPase domain	Chemotaxis phosphatase CheZ	2	1
P-loop containing nucleoside triphosphate hydrolases	Aminoacid dehydrogenase-like, N-terminal domain	2	1
Surp module (SWAP domain)	ENTH/VHS domain	2	1
Voltage-gated potassium channels	Pentapeptide repeat-like	2	1
Cysteine alpha-hairpin motif	Cysteine alpha-hairpin motif	2	2
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	2	2
Doublecortin (DC)	Protein kinase-like (PK-like)	2	1
Succinyl-CoA synthetase domains	Citrate synthase	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	P-loop containing nucleoside triphosphate hydrolases	2	1
FYVE/PHD zinc finger	Nucleotide-binding domain	2	1
eIF4e-like	WD40 repeat-like	2	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Adhesin YadA, collagen-binding domain	2	1
SET domain	HMG-box	2	1
Trimeric LpxA-like enzymes	UBA-like	2	1
Myosin rod fragments	EF-hand	2	1
ARM repeat	FabD/lysophospholipase-like	2	2
Dehydroquinate synthase-like	NAD(P)-binding Rossmann-fold domains	2	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	2	1
WD40 repeat-like	Zn-dependent exopeptidases	2	1
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	1
SNARE-like	SNARE-like	2	1
RNI-like	RING/U-box	2	1
E set domains	PP2C-like	2	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	2	1
P-loop containing nucleoside triphosphate hydrolases	DLC	2	1
RING/U-box	Nucleotide-diphospho-sugar transferases	2	1
DPP6 N-terminal domain-like	Concanavalin A-like lectins/glucanases	2	1
UBA-like	Caspase-like	2	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	Hect, E3 ligase catalytic domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Cytidine deaminase-like	2	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	TPR-like	2	1
EF-hand	Ribosomal protein L39e	2	1
SNARE-like	RING/U-box	2	1
NAD(P)-binding Rossmann-fold domains	Acyl-CoA N-acyltransferases (Nat)	2	1
L-aspartase-like	Class II aaRS ABD-related	2	1
Starch-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Undecaprenyl diphosphate synthase	Undecaprenyl diphosphate synthase	2	2
Flavoproteins	P-loop containing nucleoside triphosphate hydrolases	2	1
DUSP-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	1
Phosphoenolpyruvate/pyruvate domain	6-phosphogluconate dehydrogenase C-terminal domain-like	2	1
RING/U-box	DUSP-like	2	1
PH domain-like	TPR-like	2	1
Clathrin adaptor appendage domain	Clathrin adaptor appendage domain	2	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	1
L-aspartase-like	Class II aaRS and biotin synthetases	2	1
CRAL/TRIO domain	Phage fibre proteins	2	1
DNA repair protein MutS, domain I	GIY-YIG endonuclease	2	1
B-box zinc-binding domain	NHL repeat	2	1
Restriction endonuclease-like	Restriction endonuclease-like	2	1
EPT/RTPC-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Flavoproteins	Translation proteins	2	1
Trimeric LpxA-like enzymes	FumA C-terminal domain-like	2	1
Adenine nucleotide alpha hydrolases-like	PheT/TilS domain	2	1
SCP-like	SCP-like	2	1
E set domains	RING/U-box	2	1
GroES-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Voltage-gated potassium channels	HD-domain/PDEase-like	2	1
Starch-binding domain-like	(Phosphotyrosine protein) phosphatases II	2	1
PAZ domain	RNase III domain-like	2	1
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	Chromo domain-like	2	1
Phosphoenolpyruvate/pyruvate domain	Phosphoenolpyruvate/pyruvate domain	2	1
beta-beta-alpha zinc fingers	Major capsid protein VP5	2	1
Carbamate kinase-like	ACT-like	2	1
Starch-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	1
PAP/OAS1 substrate-binding domain	PAP/OAS1 substrate-binding domain	2	1
RNI-like	Glutathione synthetase ATP-binding domain-like	2	1
Ubiquitin-like	Chaperone J-domain	2	1
PreATP-grasp domain	Aldolase	2	1
Obg GTP-binding protein N-terminal domain	Tropomyosin	2	1
NAD kinase/diacylglycerol kinase-like	N-terminal, heterodimerisation domain of RBP7 (RpoE)	2	1
Bet v1-like	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
Periplasmic binding protein-like II	Duffy binding domain-like	2	1
S-adenosyl-L-methionine-dependent methyltransferases	NAD(P)-binding Rossmann-fold domains	2	1
SufE/NifU	Fe-S cluster assembly (FSCA) domain-like	2	1
Ankyrin repeat	Trimeric LpxA-like enzymes	2	1
Class II aaRS and biotin synthetases	TPR-like	2	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	2	1
SH3-domain	Lysozyme-like	2	1
ValRS/IleRS/LeuRS editing domain	ValRS/IleRS/LeuRS editing domain	2	1
Doublecortin (DC)	P-loop containing nucleoside triphosphate hydrolases	2	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	2	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	2	1
BRCA2 helical domain	Nucleic acid-binding proteins	2	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	2	1
Thioredoxin-like	TPR-like	2	2
ARM repeat	vWA-like	2	1
Pentapeptide repeat-like	Pentapeptide repeat-like	2	2
Starch-binding domain-like	Chromo domain-like	2	1
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Phage fibre proteins	2	1
Thioredoxin-like	P-loop containing nucleoside triphosphate hydrolases	2	2
Hypothetical protein c14orf129, hspc210	TPR-like	2	1
ACT-like	ACT-like	2	1
Concanavalin A-like lectins/glucanases	Amine oxidase N-terminal region	2	1
Protein kinase-like (PK-like)	Glutathione synthetase ATP-binding domain-like	2	1
ARM repeat	VHP, Villin headpiece domain	2	1
Supernatant protein factor (SPF), C-terminal domain	Supernatant protein factor (SPF), C-terminal domain	2	1
Dehydroquinate synthase-like	Aldolase	2	1
Rudiment single hybrid motif	Aldolase	2	1
beta-Roll	Nucleic acid-binding proteins	2	1
Voltage-gated potassium channels	Phage fibre proteins	2	1
E set domains	Quinoprotein alcohol dehydrogenase-like	2	1
Rhomboid-like	UBA-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Bacterial hemolysins	2	1
TolB, C-terminal domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Kelch motif	ARM repeat	2	1
Globin-like	GTPase activation domain, GAP	2	1
Rudiment single hybrid motif	post-HMGL domain-like	2	1
Trimeric LpxA-like enzymes	RNI-like	2	1
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	2	1
Myosin rod fragments	Ubiquitin-like	2	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Chemotaxis phosphatase CheZ	2	1
SNF-like	SNF-like	2	1
FMT C-terminal domain-like	FMT C-terminal domain-like	2	1
PapD-like	Calponin-homology domain, CH-domain	2	1
Tricorn protease domain 2	Putative isomerase YbhE	2	1
Glutathione synthetase ATP-binding domain-like	Acyl-CoA N-acyltransferases (Nat)	2	1
Six-hairpin glycosidases	Six-hairpin glycosidases	2	1
Concanavalin A-like lectins/glucanases	(Trans)glycosidases	2	1
Glutathione synthetase ATP-binding domain-like	Aldolase	2	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	2	1
GINS helical bundle-like	Acid phosphatase/Vanadium-dependent haloperoxidase	2	1
Flavoproteins	Ribosomal protein S5 domain 2-like	2	1
ARM repeat	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Ribosomal protein S10	HMG-box	2	1
F-box domain	Protein kinase-like (PK-like)	2	1
Radical SAM enzymes	Isocitrate/Isopropylmalate dehydrogenase-like	2	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	2	1
Oxidoreductase molybdopterin-binding domain	E set domains	2	1
Chaperone J-domain	GroES-like	2	1
MIR domain	EF-hand	2	1
RNI-like	ADP-ribosylglycohydrolase	2	1
Protein prenylyltransferase	Protein prenylyltransferase	2	1
Nucleotide-diphospho-sugar transferases	TPR-like	2	1
YbaK/ProRS associated domain	DBL homology domain (DH-domain)	2	1
Gamma-glutamyl cyclotransferase-like	Gamma-glutamyl cyclotransferase-like	2	1
PreATP-grasp domain	post-HMGL domain-like	2	1
Carbonic anhydrase	Carbonic anhydrase	2	2
Subtilisin-like	L domain-like	2	1
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	2	1
Tricorn protease domain 2	3-carboxy-cis,cis-mucoante lactonizing enzyme	2	1
Apolipoprotein A-I	Major surface antigen p30, SAG1	2	1
Ankyrin repeat	ADP-ribosylation	2	1
WD40 repeat-like	PP2C-like	2	1
RING/U-box	(Phosphotyrosine protein) phosphatases II	2	1
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	2	1
BAR/IMD domain-like	GTPase activation domain, GAP	2	1
C-type lectin-like	C-type lectin-like	2	1
RNI-like	HCP-like	2	1
POZ domain	Bacterial hemolysins	2	1
SWIB/MDM2 domain	SAM/Pointed domain	2	1
dsRNA-binding domain-like	RNA-binding domain, RBD	2	1
Quinoprotein alcohol dehydrogenase-like	NHL repeat	2	1
HCP-like	Trimeric LpxA-like enzymes	2	1
ARM repeat	Rhodanese/Cell cycle control phosphatase	2	1
Double-stranded DNA-binding domain	WD40 repeat-like	2	1
Chromo domain-like	Pentapeptide repeat-like	2	1
Homeodomain-like	SMAD/FHA domain	2	1
Adenine nucleotide alpha hydrolases-like	MesJ substrate recognition domain-like	2	1
Clc chloride channel	Clc chloride channel	2	1
Galactose-binding domain-like	SGNH hydrolase	2	1
Globin-like	VPS9 domain	2	1
Carboxypeptidase regulatory domain-like	Starch-binding domain-like	2	1
Dehydroquinate synthase-like	Aminoacid dehydrogenase-like, N-terminal domain	2	1
VPS9 domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Dehydroquinate synthase-like	EPT/RTPC-like	2	1
YjbQ-like	YjbQ-like	2	1
POZ domain	GAF domain-like	2	1
Protein kinase-like (PK-like)	Galactose-binding domain-like	2	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	ARM repeat	2	1
P-domain of calnexin/calreticulin	P-domain of calnexin/calreticulin	2	1
HCP-like	ARM repeat	2	1
RING/U-box	YWTD domain	2	1
"Winged helix" DNA-binding domain	Actin-like ATPase domain	2	1
EPT/RTPC-like	Aldolase	2	1
Tricorn protease domain 2	ARM repeat	2	1
CCCH zinc finger	Protein kinase-like (PK-like)	2	1
Protein kinase-like (PK-like)	Phage fibre proteins	2	1
Acyl-CoA N-acyltransferases (Nat)	Isocitrate/Isopropylmalate dehydrogenase-like	2	1
Adhesin YadA, collagen-binding domain	ARM repeat	2	1
HD-domain/PDEase-like	HD-domain/PDEase-like	2	1
GyrA/ParC C-terminal domain-like	GyrA/ParC C-terminal domain-like	2	1
Ubiquitin-like	Zn-finger domain of Sec23/24	2	1
Pectin lyase-like	RmlC-like cupins	2	1
Galactose-binding domain-like	L domain-like	2	1
Mob1/phocein	Mob1/phocein	2	1
Inhibitor of apoptosis (IAP) repeat	beta-sandwich domain of Sec23/24	2	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	PH domain-like	2	1
PH domain-like	CRAL/TRIO domain	2	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	2	1
The spindle assembly checkpoint protein mad2	The spindle assembly checkpoint protein mad2	2	1
PX domain	Quinoprotein alcohol dehydrogenase-like	2	1
RING/U-box	Ras GEF	2	1
PIN domain-like	RmlC-like cupins	2	1
R3H domain	AN1-like Zinc finger	2	1
DnaJ/Hsp40 cysteine-rich domain	DnaJ/Hsp40 cysteine-rich domain	2	1
WD40 repeat-like	Formin homology 2 domain (FH2 domain)	2	1
14-3-3 protein	LuxS/MPP-like metallohydrolase	2	1
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	2	1
Flavoproteins	EF-G C-terminal domain-like	2	1
Tropomyosin	PspA lactotransferrin-binding region	2	1
ARM repeat	beta-sandwich domain of Sec23/24	2	2
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	2	1
Purine and uridine phosphorylases	RNA-binding domain, RBD	2	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	2	1
ARM repeat	Bromodomain	2	1
PLP-binding barrel	PLP-binding barrel	2	1
Cysteine proteinases	Mannose 6-phosphate receptor domain	2	1
BRCT domain	ADP-ribosylation	2	1
Galactose mutarotase-like	Galactose mutarotase-like	2	1
CRAL/TRIO N-terminal domain	Phage fibre proteins	2	1
Quinoprotein alcohol dehydrogenase-like	YWTD domain	2	1
FAD-linked reductases, C-terminal domain	CPE0013-like	2	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	YbiA-like	2	1
PP2C-like	Pentapeptide repeat-like	2	1
WW domain	FYVE/PHD zinc finger	2	1
RNA-binding domain, RBD	Galactose-binding domain-like	2	1
Tricorn protease N-terminal domain	alpha/beta-Hydrolases	2	1
GTPase activation domain, GAP	Ubiquitin-like	2	1
Rnp2-like	SufE/NifU	2	2
Formin homology 2 domain (FH2 domain)	RNA-binding domain, RBD	2	1
Class II aaRS and biotin synthetases	Heat shock protein 70kD (HSP70), C-terminal subdomain	2	1
P-loop containing nucleoside triphosphate hydrolases	Aldolase	2	1
RING/U-box	Tubulin chaperone cofactor A	2	1
P-loop containing nucleoside triphosphate hydrolases	Formin homology 2 domain (FH2 domain)	2	2
ThrRS/AlaRS common domain	ThrRS/AlaRS common domain	2	2
Pentapeptide repeat-like	Quinoprotein alcohol dehydrogenase-like	2	1
WD40 repeat-like	Sec1/munc18-like (SM) proteins	2	1
Concanavalin A-like lectins/glucanases	DmpA/ArgJ-like	2	1
Acyl-CoA N-acyltransferases (Nat)	FAD/NAD(P)-binding domain	2	1
Trimeric LpxA-like enzymes	Hect, E3 ligase catalytic domain	2	1
EF-hand	Glycerol-3-phosphate (1)-acyltransferase	2	1
Mss4-like	Doublecortin (DC)	2	1
Concanavalin A-like lectins/glucanases	Hairpin loop containing domain-like	2	1
Cyclophilin-like	Cyclophilin-like	2	1
Cysteine proteinases	YccV-like	2	1
FYVE/PHD zinc finger	Tropomyosin	2	1
Carbohydrate phosphatase	beta-beta-alpha zinc fingers	2	1
DBL homology domain (DH-domain)	Galactose oxidase, central domain	2	1
Metallo-hydrolase/oxidoreductase	Phage fibre proteins	2	1
RNA-binding domain, RBD	POZ domain	2	1
Ubiquitin-like	vWA-like	2	1
Ubiquitin-like	C-terminal, gelsolin-like domain of Sec23/24	2	1
GIY-YIG endonuclease	Cysteine-rich domain	2	1
RNI-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
RING/U-box	Quinoprotein alcohol dehydrogenase-like	2	1
B-box zinc-binding domain	Calcium-dependent phosphotriesterase	2	1
PH domain-like	Pseudo ankyrin repeat-like	2	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	2	1
Apolipoprotein	Bet v1-like	2	1
Ypt/Rab-GAP domain of gyp1p	Zn-finger domain of Sec23/24	2	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	2	1
Spectrin repeat	Spectrin repeat	2	1
Quinoprotein alcohol dehydrogenase-like	TPR-like	2	1
Kelch motif	WD40 repeat-like	2	1
ASF1-like	ASF1-like	2	1
Amine oxidase N-terminal region	Amine oxidase catalytic domain	2	1
AttH-like	Lipocalins	2	1
Calponin-homology domain, CH-domain	Myosin rod fragments	2	1
Serine metabolism enzymes domain	ACT-like	2	1
Citrate synthase	Citrate synthase	2	1
Galactose oxidase, central domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	1
Prokaryotic type I DNA topoisomerase	Prokaryotic type I DNA topoisomerase	2	1
UBA-like	Hect, E3 ligase catalytic domain	2	1
Thioredoxin-like	PUG domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	UBA-like	2	1
Tricorn protease domain 2	RING/U-box	2	1
beta-N-acetylhexosaminidase-like domain	Galactose-binding domain-like	2	1
TPR-like	F-box domain	2	1
PYP-like sensor domain (PAS domain)	SMAD/FHA domain	2	1
B-box zinc-binding domain	TPR-like	2	1
Tropomyosin	alpha/beta knot	2	1
Protein kinase-like (PK-like)	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Enolase N-terminal domain-like	ARM repeat	2	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	TPR-like	2	1
(Trans)glycosidases	Invasin/intimin cell-adhesion fragments	2	1
Protein prenylyltransferase	L domain-like	2	2
Dehydroquinate synthase-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Aldolase	NAD(P)-binding Rossmann-fold domains	2	1
Acetyl-CoA synthetase-like	P-loop containing nucleoside triphosphate hydrolases	2	1
P-loop containing nucleoside triphosphate hydrolases	WW domain	2	1
F-box domain	L domain-like	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	2	1
Ubiquitin-like	beta-sandwich domain of Sec23/24	2	1
FYVE/PHD zinc finger	E set domains	2	1
Ras GEF	Ankyrin repeat	2	1
Actin-like ATPase domain	RNA-binding domain, RBD	2	1
Tricorn protease N-terminal domain	Formin homology 2 domain (FH2 domain)	2	1
Dihydropteroate synthetase-like	Adhesin YadA, collagen-binding domain	2	1
HIT/MYND zinc finger-like	TPR-like	2	1
MesJ substrate recognition domain-like	PheT/TilS domain	2	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	2	1
C-terminal domain of Ku80	C-terminal domain of Ku80	2	1
FAD/NAD(P)-binding domain	PurM C-terminal domain-like	2	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	2	1
Acyl-CoA binding protein	PH domain-like	2	1
Calcyclin-binding protein-like	HSP20-like chaperones	2	1
Sm-like ribonucleoproteins	Ribosomal protein L30p/L7e	2	1
EPT/RTPC-like	NAD(P)-binding Rossmann-fold domains	2	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	2	1
Kelch motif	S-adenosyl-L-methionine-dependent methyltransferases	2	2
P-loop containing nucleoside triphosphate hydrolases	PLP-dependent transferases	2	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	alpha/beta-Hydrolases	2	1
beta-Roll	P-loop containing nucleoside triphosphate hydrolases	2	1
PP2C-like	ACP-like	2	1
RCC1/BLIP-II	Phage fibre proteins	2	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	2	1
SSo0622-like	SSo0622-like	2	1
NAD kinase/diacylglycerol kinase-like	Nucleic acid-binding proteins	2	1
Cysteine proteinases	Protein kinase-like (PK-like)	2	1
Tricorn protease domain 2	Cysteine-rich domain	2	1
Glucocorticoid receptor-like (DNA-binding domain)	PH domain-like	2	1
Calcium ATPase, transduction domain A	Calcium ATPase, transduction domain A	2	1
WRKY DNA-binding domain	WRKY DNA-binding domain	2	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	TPR-like	2	2
Growth factor receptor domain	Oligoxyloglucan reducing end-specific cellobiohydrolase	2	1
Fe-only hydrogenase	Fe-only hydrogenase	2	1
EF-hand	Nucleotide cyclase	2	1
Creatinase/prolidase N-terminal domain	Creatinase/prolidase N-terminal domain	2	2
CinA-like	Nucleotidylyl transferase	2	1
Glycosyl hydrolase domain	Galactose-binding domain-like	2	1
Protein kinase-like (PK-like)	t-snare proteins	2	1
PH domain-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Cytochrome c oxidase subunit I-like	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	2	1
Lysozyme-like	beta-lactamase/transpeptidase-like	2	1
Acyl-CoA binding protein	CRAL/TRIO domain	2	1
B-box zinc-binding domain	YWTD domain	2	1
Surp module (SWAP domain)	Retrovirus zinc finger-like domains	2	1
cAMP-binding domain-like	Purine and uridine phosphorylases	2	1
vWA-like	Terpenoid cyclases/Protein prenyltransferases	2	1
P-loop containing nucleoside triphosphate hydrolases	GIY-YIG endonuclease	2	1
Phosphoglycerate kinase	cAMP-binding domain-like	2	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	2	1
Radical SAM enzymes	Radical SAM enzymes	2	1
Hypothetical protein PH1602	Hypothetical protein PH1602	2	1
Class II aaRS and biotin synthetases	Actin-like ATPase domain	2	1
POZ domain	HCP-like	2	1
FAD/NAD(P)-binding domain	PurM N-terminal domain-like	2	1
Intermediate filament protein, coiled coil region	Ankyrin repeat	2	1
Smc hinge domain	Myosin rod fragments	2	2
EPT/RTPC-like	Aminoacid dehydrogenase-like, N-terminal domain	2	1
DNA-glycosylase	DNA-glycosylase	2	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	2	1
Protein kinase-like (PK-like)	Pseudo ankyrin repeat-like	2	1
occludin/ELL-like	PH domain-like	2	1
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	2	1
Enolase N-terminal domain-like	WD40 repeat-like	2	1
Chaperone J-domain	Metallo-dependent phosphatases	2	1
SNARE fusion complex	P-loop containing nucleoside triphosphate hydrolases	2	1
Ribosomal protein L1	Ribosomal protein L1	2	1
Spermadhesin, CUB domain	Hect, E3 ligase catalytic domain	2	1
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	2	1
His-Me finger endonucleases	His-Me finger endonucleases	2	1
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	Ankyrin repeat	2	1
PLP-dependent transferases	PK beta-barrel domain-like	2	1
Phosphoenolpyruvate/pyruvate domain	NAD(P)-binding Rossmann-fold domains	2	1
L domain-like	Glutathione synthetase ATP-binding domain-like	2	1
tRNA-guanine transglycosylase	tRNA-guanine transglycosylase	2	1
(Phosphotyrosine protein) phosphatases II	RNI-like	2	1
BAR/IMD domain-like	UBA-like	2	1
PurM C-terminal domain-like	PurM C-terminal domain-like	2	1
beta-Roll	Initiation factor IF2/eIF5b, domain 3	2	1
Fe-only hydrogenase	E set domains	2	1
Nucleic acid-binding proteins	BRCT domain	2	1
NAD(P)-binding Rossmann-fold domains	SCP-like	2	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	2	1
PAP/OAS1 substrate-binding domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Bacterial hemolysins	Galactose-binding domain-like	2	1
Glutathione synthetase ATP-binding domain-like	Citrate synthase	2	1
P-loop containing nucleoside triphosphate hydrolases	S-adenosyl-L-methionine-dependent methyltransferases	2	2
Tex N-terminal region-like	SH2 domain	2	1
DPP6 N-terminal domain-like	Hect, E3 ligase catalytic domain	2	1
Outer arm dynein light chain 1	Tropomyosin	2	1
MoeA N-terminal region -like	MoeA N-terminal region -like	2	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	2	1
Thiolase-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Riboflavin kinase-like	Riboflavin kinase-like	2	1
post-AAA+ oligomerization domain-like	post-AAA+ oligomerization domain-like	2	1
Protein kinase-like (PK-like)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	2	1
ARM repeat	ThrRS/AlaRS common domain	2	1
Sialidases	DmpA/ArgJ-like	2	1
MgtE N-terminal domain-like	MgtE N-terminal domain-like	2	1
Tubulin chaperone cofactor A	WD40 repeat-like	2	1
CheY-like	HD-domain/PDEase-like	2	1
Nucleotide-diphospho-sugar transferases	FKBP-like	2	1
Myosin rod fragments	NSFL1 (p97 ATPase) cofactor p47, SEP domain	2	1
WW domain	C-terminal domain of PLC-beta	2	1
Thioredoxin-like	"Winged helix" DNA-binding domain	2	1
PH domain-like	FKBP-like	2	1
Apolipoprotein A-I	Apolipoprotein A-I	2	2
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	2	1
ARM repeat	Tricorn protease N-terminal domain	2	1
Ankyrin repeat	FYVE/PHD zinc finger	2	1
Protein kinase-like (PK-like)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	1
GTPase activation domain, GAP	EF-hand	2	1
S-adenosyl-L-methionine-dependent methyltransferases	TPR-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Trimeric LpxA-like enzymes	2	1
Eukaryotic DNA topoisomerase I, dispensable insert domain	EGF/Laminin	2	1
TPR-like	UDP-Glycosyltransferase/glycogen phosphorylase	2	1
RNI-like	Tricorn protease domain 2	2	2
ITPase-like	Nucleotide-diphospho-sugar transferases	2	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	2	1
Concanavalin A-like lectins/glucanases	Growth factor receptor domain	2	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	WD40 repeat-like	2	1
DPP6 N-terminal domain-like	DPP6 N-terminal domain-like	2	1
BEACH domain	FYVE/PHD zinc finger	2	1
CoaB-like	CoaB-like	2	1
Pentapeptide repeat-like	Translation proteins	2	2
SH3-domain	ARM repeat	2	1
Outer arm dynein light chain 1	RNI-like	2	2
GreA transcript cleavage protein, N-terminal domain	FKBP-like	2	1
Ubiquitin-like	HCP-like	2	1
PTPA-like	PTPA-like	2	1
PapD-like	GTPase activation domain, GAP	2	1
Bet v1-like	WD40 repeat-like	2	1
Subtilisin-like	Growth factor receptor domain	2	1
Protein kinase-like (PK-like)	Enolase N-terminal domain-like	2	1
Roadblock/LC7 domain	Glycerol-3-phosphate (1)-acyltransferase	2	1
BRCT domain	WGR domain-like	2	1
Pseudo ankyrin repeat-like	Metallo-hydrolase/oxidoreductase	2	1
Soluble quinoprotein glucose dehydrogenase	Quinoprotein alcohol dehydrogenase-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
Notch domain	Notch domain	2	1
Cytochrome b5-like heme/steroid binding domain	E set domains	2	1
Succinyl-CoA synthetase domains	Acyl-CoA N-acyltransferases (Nat)	2	1
WD40 repeat-like	Myosin rod fragments	2	1
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Pectin lyase-like	HD-domain/PDEase-like	2	2
POZ domain	HD-domain/PDEase-like	2	1
SMAD/FHA domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
beta-Roll	Translation proteins	2	1
Putative isomerase YbhE	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Aquaporin-like	Aquaporin-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	2	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	FYVE/PHD zinc finger	2	1
WD40 repeat-like	FYVE/PHD zinc finger	2	1
FabD/lysophospholipase-like	P-loop containing nucleoside triphosphate hydrolases	2	1
PYP-like sensor domain (PAS domain)	GAF domain-like	1	1
Protein kinase-like (PK-like)	Mss4-like	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1
SRCR-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein kinase-like (PK-like)	Release factor	1	1
Ribosomal protein L1	WD40 repeat-like	1	1
Cytokine	SAICAR synthase-like	1	1
Periplasmic binding protein-like II	Calcium ATPase, transmembrane domain M	1	1
RNA polymerase subunits	PUG domain-like	1	1
Phosphoglycerate mutase-like	Acid proteases	1	1
Phosphoglucomutase, C-terminal domain	PRTase-like	1	1
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	1	1
FYVE/PHD zinc finger	Hect, E3 ligase catalytic domain	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	GYF domain	1	1
N-terminal Zn binding domain of HIV integrase	Ribonuclease H-like	1	1
DNase I-like	Aminoacid dehydrogenase-like, N-terminal domain	1	1
B-box zinc-binding domain	PH domain-like	1	1
WD40 repeat-like	SNARE fusion complex	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	GAF domain-like	1	1
ITPase-like	ITPase-like	1	1
MCP/YpsA-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Acetyl-CoA synthetase-like	Folate-binding domain	1	1
Ribosomal protein L22	Ribosomal protein L22	1	1
alpha/beta-Hydrolases	TPR-like	1	1
ALDH-like	ALDH-like	1	1
RNase III domain-like	"Winged helix" DNA-binding domain	1	1
Pre-PUA domain	Pre-PUA domain	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	HCP-like	1	1
ARM repeat	Arginase/deacetylase	1	1
Aldolase	LuxS/MPP-like metallohydrolase	1	1
Pentapeptide repeat-like	Ribosomal protein S5 domain 2-like	1	1
DNase I-like	NAD(P)-binding Rossmann-fold domains	1	1
Metal cation-transporting ATPase, ATP-binding domain N	Periplasmic binding protein-like II	1	1
Concanavalin A-like lectins/glucanases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
CRAL/TRIO domain	alpha/beta-Hydrolases	1	1
Myosin rod fragments	PAH2 domain	1	1
Metalloproteases ("zincins"), catalytic domain	Rhomboid-like	1	1
WD40 repeat-like	AN1-like Zinc finger	1	1
WD40 repeat-like	Peptidase/esterase 'gauge' domain	1	1
EF-hand	Putative isomerase YbhE	1	1
THUMP domain-like	PP2C-like	1	1
B-box zinc-binding domain	Apolipoprotein	1	1
PX domain	ARM repeat	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	1	1
PH domain-like	RNI-like	1	1
Quinoprotein alcohol dehydrogenase-like	Insect cysteine-rich antifreeze protein	1	1
DmpA/ArgJ-like	L domain-like	1	1
Protein prenylyltransferase	RNI-like	1	1
Tropomyosin	DNase I-like	1	1
Quinoprotein alcohol dehydrogenase-like	Ribonuclease H-like	1	1
Insect cysteine-rich antifreeze protein	S-adenosyl-L-methionine-dependent methyltransferases	1	1
beta-sandwich domain of Sec23/24	RING/U-box	1	1
PH domain-like	Kelch motif	1	1
Quinoprotein alcohol dehydrogenase-like	Nucleoporin domain	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
RING/U-box	SET domain	1	1
RNI-like	Growth factor receptor domain	1	1
Cysteine proteinases	UBC-like	1	1
Ran binding protein zinc finger-like	Cyclin-like	1	1
Insect cysteine-rich antifreeze protein	Galactose oxidase, central domain	1	1
Ribosomal protein L16p/L10e	Ribosomal protein L14	1	1
ARM repeat	GroEL apical domain-like	1	1
PYP-like sensor domain (PAS domain)	P-loop containing nucleoside triphosphate hydrolases	1	1
FYVE/PHD zinc finger	Myosin rod fragments	1	1
Metallo-dependent phosphatases	Metallo-dependent phosphatases	1	1
Cullin homology domain	Cullin homology domain	1	1
YWTD domain	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
Pentapeptide repeat-like	Nucleotidylyl transferase	1	1
beta-sandwich domain of Sec23/24	HAD-like	1	1
Formin homology 2 domain (FH2 domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
beta-sandwich domain of Sec23/24	GYF domain	1	1
tRNA-binding arm	tRNA-binding arm	1	1
RNI-like	NHL repeat	1	1
Nucleoporin domain	Bromodomain	1	1
Protein kinase-like (PK-like)	Cyclin-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	P-loop containing nucleoside triphosphate hydrolases	1	1
FYVE/PHD zinc finger	Clavaminate synthase-like	1	1
Pentapeptide repeat-like	EF-G C-terminal domain-like	1	1
UBC-like	Release factor	1	1
HesB-like domain	HesB-like domain	1	1
Ubiquitin-like	UBC-like	1	1
beta-sandwich domain of Sec23/24	FtsH protease domain-like	1	1
Tim10-like	PIN domain-like	1	1
dUTPase-like	dUTPase-like	1	1
GroEL equatorial domain-like	GroEL equatorial domain-like	1	1
Ankyrin repeat	Acyl-CoA N-acyltransferases (Nat)	1	1
Double Clp-N motif	Double Clp-N motif	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
Glycerol-3-phosphate (1)-acyltransferase	Acetyl-CoA synthetase-like	1	1
Concanavalin A-like lectins/glucanases	Ankyrin repeat	1	1
Adhesin YadA, collagen-binding domain	SET domain	1	1
Kelch motif	Insect cysteine-rich antifreeze protein	1	1
Zn-dependent exopeptidases	DNA polymerase III chi subunit	1	1
Cell-division protein ZipA, C-terminal domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
EGF/Laminin	ARM repeat	1	1
TM1631-like	TM1631-like	1	1
Outer arm dynein light chain 1	RmlC-like cupins	1	1
WD40 repeat-like	Insect cysteine-rich antifreeze protein	1	1
beta-sandwich domain of Sec23/24	ClpP/crotonase	1	1
PH domain-like	SAM/Pointed domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	L9 N-domain-like	1	1
Clavaminate synthase-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	P-loop containing nucleoside triphosphate hydrolases	1	1
SAP domain	Restriction endonuclease-like	1	1
Galactose mutarotase-like	beta-sandwich domain of Sec23/24	1	1
RING/U-box	Outer arm dynein light chain 1	1	1
ADP-ribosylation	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
Nucleotide-diphospho-sugar transferases	EF-hand	1	1
Release factor	P-loop containing nucleoside triphosphate hydrolases	1	1
Cyclin-like	Hect, E3 ligase catalytic domain	1	1
Trimeric LpxA-like enzymes	Obg GTP-binding protein N-terminal domain	1	1
Pentapeptide repeat-like	SET domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Pentapeptide repeat-like	1	1
Tropomyosin	EB1 dimerisation domain-like	1	1
beta-beta-alpha zinc fingers	HSP20-like chaperones	1	1
B-box zinc-binding domain	B-box zinc-binding domain	1	1
FYVE/PHD zinc finger	Tudor/PWWP/MBT	1	1
Kelch motif	Clavaminate synthase-like	1	1
Eukaryotic RPB5 N-terminal domain	Eukaryotic RPB5 N-terminal domain	1	1
Tim10-like	5' to 3' exonuclease, C-terminal subdomain	1	1
N-terminal Zn binding domain of HIV integrase	DNA-binding domain of retroviral integrase	1	1
Nucleotidyltransferase	Nucleotidyltransferase	1	1
cAMP-binding domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	S-adenosyl-L-methionine-dependent methyltransferases	1	1
DNA clamp	Translation proteins	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
Pentapeptide repeat-like	Putative DNA-binding domain	1	1
Concanavalin A-like lectins/glucanases	Formin homology 2 domain (FH2 domain)	1	1
ABC transporter transmembrane region	Ankyrin repeat	1	1
PapD-like	RPB6/omega subunit-like	1	1
P-loop containing nucleoside triphosphate hydrolases	BAR/IMD domain-like	1	1
Cyclin-like	Concanavalin A-like lectins/glucanases	1	1
RING/U-box	TSP-1 type 1 repeat	1	1
Ribonuclease H-like	DNA-binding domain of retroviral integrase	1	1
RING/U-box	Calcium ATPase, transmembrane domain M	1	1
Microbial and mitochondrial ADK, insert "zinc finger" domain	EF-hand	1	1
GAF domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Phosphoglucomutase, first 3 domains	PRTase-like	1	1
beta-sandwich domain of Sec23/24	Six-hairpin glycosidases	1	1
RNI-like	Tricorn protease N-terminal domain	1	1
Calcium ATPase, transduction domain A	Periplasmic binding protein-like II	1	1
MgtE membrane domain-like	MgtE membrane domain-like	1	1
Rhomboid-like	Rhomboid-like	1	1
WD40 repeat-like	Glucocorticoid receptor-like (DNA-binding domain)	1	1
beta-sandwich domain of Sec23/24	Homeodomain-like	1	1
Chaperone J-domain	Protein kinase-like (PK-like)	1	1
Acid proteases	Ribonuclease H-like	1	1
Macro domain-like	DNA polymerase III chi subunit	1	1
PUA domain-like	Ribosomal protein S5 domain 2-like	1	1
Arginase/deacetylase	Cytokine	1	1
Insect cysteine-rich antifreeze protein	Insect cysteine-rich antifreeze protein	1	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Single hybrid motif	beta-sandwich domain of Sec23/24	1	1
Metalloproteases ("zincins"), catalytic domain	Ubiquitin-like	1	1
Smp-1-like	Calpain large subunit, middle domain (domain III)	1	1
LCCL domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein prenylyltransferase	Rps17e-like	1	1
DhaL-like	Rhomboid-like	1	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	1	1
Voltage-gated potassium channels	Small-conductance potassium channel	1	1
WD40 repeat-like	Soluble quinoprotein glucose dehydrogenase	1	1
beta-sandwich domain of Sec23/24	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal protein L25-like	Ribosomal protein L25-like	1	1
beta-sandwich domain of Sec23/24	CoA-dependent acyltransferases	1	1
Periplasmic binding protein-like II	HAD-like	1	1
C-type lectin-like	Trimeric LpxA-like enzymes	1	1
RNI-like	DPP6 N-terminal domain-like	1	1
PLC-like phosphodiesterases	PDZ domain-like	1	1