Domain combination pairs in Natrinema pellirubrum DSM 15624

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

472 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	22	19
PYP-like sensor domain (PAS domain)	GAF domain-like	22	20
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	21	19
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	20	15
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	19	5
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	17	8
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	16	13
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	15	3
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	14	4
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	14	1
Calcium ATPase, transduction domain A	HAD-like	13	8
Cyclin-like	Cyclin-like	13	2
Zinc beta-ribbon	Cyclin-like	13	2
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	12	7
HAD-like	Calcium ATPase, transmembrane domain M	12	7
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	12	2
Thiolase-like	Thiolase-like	11	2
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	11	2
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	10	9
CheY-like	GAF domain-like	9	7
"Winged helix" DNA-binding domain	GAF domain-like	9	1
GroES-like	NAD(P)-binding Rossmann-fold domains	9	2
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	9	1
GAF domain-like	GAF domain-like	9	8
CheY-like	PYP-like sensor domain (PAS domain)	9	7
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	8	7
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	8	3
HMA, heavy metal-associated domain	HAD-like	8	6
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	8	6
CheY-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	7	6
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	7	5
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	7	2
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	7	6
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	7	2
TrkA C-terminal domain-like	TrkA C-terminal domain-like	7	4
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	6	2
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	6	4
Enolase N-terminal domain-like	Enolase C-terminal domain-like	6	1
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	6	1
CheY-like	Homodimeric domain of signal transducing histidine kinase	6	5
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	6	1
GAF domain-like	Sigma3 and sigma4 domains of RNA polymerase sigma factors	5	5
Nucleic acid-binding proteins	Nucleic acid-binding proteins	5	5
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	5	1
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	5	1
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	5	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	5	2
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	5	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	5	1
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	5	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	5	1
PurM N-terminal domain-like	PurM C-terminal domain-like	5	2
PYP-like sensor domain (PAS domain)	Sigma3 and sigma4 domains of RNA polymerase sigma factors	5	5
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	5	4
P-loop containing nucleoside triphosphate hydrolases	MOP-like	5	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	4
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	4	2
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	4	1
Cupredoxins	Cupredoxins	4	2
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	4	2
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	4	3
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	4	1
TATA-box binding protein-like	TATA-box binding protein-like	4	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	4	2
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	4	2
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	4	3
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	4	1
Periplasmic binding protein-like II	Periplasmic binding protein-like II	4	2
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	4	3
Hedgehog/intein (Hint) domain	Homing endonucleases	4	3
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	4	1
Rhodanese/Cell cycle control phosphatase	Metallo-hydrolase/oxidoreductase	4	1
PreATP-grasp domain	Rudiment single hybrid motif	4	2
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	4	1
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	3	2
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	3	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	3	1
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	3	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	3
FAD-linked oxidases, C-terminal domain	alpha-helical ferredoxin	3	1
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	3	2
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
FAD-binding/transporter-associated domain-like	alpha-helical ferredoxin	3	1
GroEL equatorial domain-like	GroEL apical domain-like	3	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	3	1
Sm-like ribonucleoproteins	Mechanosensitive channel protein MscS (YggB), C-terminal domain	3	2
ClpP/crotonase	ClpP/crotonase	3	2
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	3	2
Aminoacid dehydrogenase-like, N-terminal domain	Isocitrate/Isopropylmalate dehydrogenase-like	3	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	2
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	3	2
Ribosomal protein S5 domain 2-like	EF-G C-terminal domain-like	3	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	3	1
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	3	2
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	3	2
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	3	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	3	1
CBS-domain pair	FAD-binding/transporter-associated domain-like	3	1
ADC-like	Cdc48 domain 2-like	3	1
NAD(P)-binding Rossmann-fold domains	Isocitrate/Isopropylmalate dehydrogenase-like	3	1
GroEL-intermediate domain like	GroEL apical domain-like	3	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	3	3
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	3	2
Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, C-terminal domains	3	1
Nqo5-like	HydB/Nqo4-like	3	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	3	3
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	3
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	3	2
GroEL equatorial domain-like	GroEL-intermediate domain like	3	1
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	2	2
Actin-like ATPase domain	Actin-like ATPase domain	2	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	2
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	2	1
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	2	1
Cytochrome c oxidase subunit I-like	Cytochrome c oxidase subunit III-like	2	1
Succinyl-CoA synthetase domains	Glutathione synthetase ATP-binding domain-like	2	2
Phospholipase D/nuclease	Phospholipase D/nuclease	2	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	2	2
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	2	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
Nucleic acid-binding proteins	DHH phosphoesterases	2	2
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	2	2
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	2	1
Folate-binding domain	Aminomethyltransferase beta-barrel domain	2	1
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	2	2
Rudiment single hybrid motif	Single hybrid motif	2	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Trypsin-like serine proteases	PDZ domain-like	2	2
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Thiamin diphosphate-binding fold (THDP-binding)	2	1
PhoU-like	PhoU-like	2	2
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	2	1
Translational machinery components	L30e-like	2	2
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	2	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	2
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	2
CBS-domain pair	CBS-domain pair	2	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	2	2
ACT-like	ACT-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	2	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	2	1
Translation proteins	ThrRS/AlaRS common domain	2	2
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	2	2
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	2	2
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	2	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	2	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	2	1
6-phosphogluconate dehydrogenase C-terminal domain-like	ClpP/crotonase	2	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	2
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	2	1
tRNA-guanine transglycosylase	Pre-PUA domain	2	2
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	2	1
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	2	2
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	2	2
MetI-like	MetI-like	2	2
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	2	2
FMN-binding split barrel	UbiD C-terminal domain-like	2	2
PreATP-grasp domain	Single hybrid motif	2	1
Ribbon-helix-helix	ACT-like	2	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	2	1
Thioredoxin-like	Six-hairpin glycosidases	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	2
"Winged helix" DNA-binding domain	Class II aaRS and biotin synthetases	2	2
Nucleotidyltransferase	"Winged helix" DNA-binding domain	2	2
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	2	2
NagB/RpiA/CoA transferase-like	alpha-helical ferredoxin	2	1
Pre-PUA domain	PUA domain-like	2	2
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	2	2
Oxidoreductase molybdopterin-binding domain	E set domains	2	2
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	TK C-terminal domain-like	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
Voltage-gated potassium channels	TrkA C-terminal domain-like	2	1
Translation proteins SH3-like domain	Nucleic acid-binding proteins	2	2
NAD(P)-binding Rossmann-fold domains	DHH phosphoesterases	2	1
NAD(P)-binding Rossmann-fold domains	ClpP/crotonase	2	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	2	2
Glutamine synthetase/guanido kinase	GatB/YqeY motif	2	2
lambda repressor-like DNA-binding domains	AraD/HMP-PK domain-like	2	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	2	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	2	1
lambda repressor-like DNA-binding domains	CBS-domain pair	1	1
Formyltransferase	Cytidine deaminase-like	1	1
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Mechanosensitive channel protein MscS (YggB), C-terminal domain	1	1
Respiratory nitrate reductase 1 gamma chain	alpha-helical ferredoxin	1	1
Ribonuclease H-like	Homing endonucleases	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
PPK N-terminal domain-like	Phospholipase D/nuclease	1	1
Homing endonucleases	P-loop containing nucleoside triphosphate hydrolases	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease catalytic domain-like	1	1
Hedgehog/intein (Hint) domain	lambda repressor-like DNA-binding domains	1	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
DNA breaking-rejoining enzymes	GAF domain-like	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
Nudix	NagB/RpiA/CoA transferase-like	1	1
CheC-like	CheC-like	1	1
Ferritin-like	Ferritin-like	1	1
PhoU-like	TrkA C-terminal domain-like	1	1
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
P-loop containing nucleoside triphosphate hydrolases	ARM repeat	1	1
Rhodanese/Cell cycle control phosphatase	Nitrite/Sulfite reductase N-terminal domain-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Rhodanese/Cell cycle control phosphatase	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
Thioredoxin-like	GST C-terminal domain-like	1	1
MurD-like peptide ligases, catalytic domain	Dihydropteroate synthetase-like	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
Uracil-DNA glycosylase-like	PUA domain-like	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
Initiation factor IF2/eIF5b, domain 3	Translation proteins	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	1	1
Myosin rod fragments	Tropomyosin	1	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
"Winged helix" DNA-binding domain	TrmB C-terminal domain-like	1	1
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	1	1
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	1	1
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	1	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	1	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	1	1
Uracil-DNA glycosylase-like	Pre-PUA domain	1	1
Restriction endonuclease-like	RuvA domain 2-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Metallo-hydrolase/oxidoreductase	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	1	1
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
DNA-glycosylase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
PK beta-barrel domain-like	Phosphohistidine domain	1	1
Chemotaxis receptor methyltransferase CheR, N-terminal domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
GIY-YIG endonuclease	RuvA domain 2-like	1	1
FAD/NAD(P)-binding domain	ISP domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
MFS general substrate transporter	MFS general substrate transporter	1	1
Histidine-containing phosphotransfer domain, HPT domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Zinc-binding domain of translation initiation factor 2 beta	Nucleic acid-binding proteins	1	1
Single hybrid motif	CoA-dependent acyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	1	1
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	1	1
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	1	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	1	1
Pectin lyase-like	Pectin lyase-like	1	1
Ribonuclease H-like	DNA/RNA polymerases	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	1	1
Globin-like	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
Histidine-containing phosphotransfer domain, HPT domain	Homodimeric domain of signal transducing histidine kinase	1	1
Homing endonucleases	Homing endonucleases	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Myosin rod fragments	Myosin rod fragments	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Translation proteins	Ribosomal protein S5 domain 2-like	1	1
Hypothetical protein PH1602	Hypothetical protein PH1602	1	1
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
HAD-like	Nudix	1	1
tRNA-guanine transglycosylase	PUA domain-like	1	1
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	1	1
Homodimeric domain of signal transducing histidine kinase	CheW-like	1	1
DnaJ/Hsp40 cysteine-rich domain	Pseudouridine synthase	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
Lamin A/C globular tail domain	Metallo-hydrolase/oxidoreductase	1	1
PHP14-like	Phospholipase D/nuclease	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
Sec63 N-terminal domain-like	PHP domain-like	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
PIN domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
ACT-like	Formyltransferase	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
Nucleotide-diphospho-sugar transferases	Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain	1	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	1	1
Succinyl-CoA synthetase domains	Succinyl-CoA synthetase domains	1	1
GIY-YIG endonuclease	C-terminal UvrC-binding domain of UvrB	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
Actin-like ATPase domain	Protein kinase-like (PK-like)	1	1
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	1	1
Nucleotidyltransferase	PHP domain-like	1	1
Ribonuclease H-like	Hedgehog/intein (Hint) domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Homing endonucleases	DNA/RNA polymerases	1	1
Rad51 N-terminal domain-like	Ribonuclease H-like	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
FYSH domain	EF-G C-terminal domain-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	1	1
GroES-like	GroES-like	1	1
GAD domain-like	GatB/YqeY motif	1	1
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	1	1
P-loop containing nucleoside triphosphate hydrolases	Acyl-CoA N-acyltransferases (Nat)	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheW-like	1	1
Cna protein B-type domain	Cna protein B-type domain	1	1
Pentapeptide repeat-like	Pentapeptide repeat-like	1	1
Pseudouridine synthase	PUA domain-like	1	1
DNA breaking-rejoining enzymes	PYP-like sensor domain (PAS domain)	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
Radical SAM enzymes	PsbU/PolX domain-like	1	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	1	1
Thiolase-like	Nucleic acid-binding proteins	1	1
Smc hinge domain	Tropomyosin	1	1
Rad51 N-terminal domain-like	Ribosomal protein L32e	1	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Glutathione synthetase ATP-binding domain-like	Acid proteases	1	1
Bacterial fluorinating enzyme, N-terminal domain	Bacterial fluorinating enzyme, C-terminal domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
Histone-fold	Histone-fold	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
GatD N-terminal domain-like	Glutaminase/Asparaginase	1	1
Hedgehog/intein (Hint) domain	Hypothetical protein PH1602	1	1
Translation proteins	EF-G C-terminal domain-like	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
PIN domain-like	Prokaryotic type KH domain (KH-domain type II)	1	1
lambda repressor-like DNA-binding domains	P-loop containing nucleoside triphosphate hydrolases	1	1
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	1	1
Nucleotidylyl transferase	Ribosomal protein L25-like	1	1
PK C-terminal domain-like	Phosphohistidine domain	1	1
Ammonium transporter	GlnB-like	1	1
Cupredoxins	Soluble quinoprotein glucose dehydrogenase	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
Zn-dependent exopeptidases	PKD domain	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	1	1
"Winged helix" DNA-binding domain	Phospholipase D/nuclease	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	1	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	1	1
alpha/beta-Hydrolases	Rad51 N-terminal domain-like	1	1
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	1	1
Sec63 N-terminal domain-like	Nucleotidyltransferase	1	1
YegP-like	YegP-like	1	1
NAD(P)-binding Rossmann-fold domains	Siroheme synthase middle domains-like	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
CbiG N-terminal domain-like	CobE/GbiG C-terminal domain-like	1	1
Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	1	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
PDZ domain-like	PDZ domain-like	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
PPK N-terminal domain-like	PHP14-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
THUMP domain-like	Adenine nucleotide alpha hydrolases-like	1	1
DNA clamp	DNA clamp	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
Carbamate kinase-like	ACT-like	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
Heme-dependent peroxidases	Heme-dependent peroxidases	1	1
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	1	1
RuvA domain 2-like	BRCT domain	1	1
"Winged helix" DNA-binding domain	TrkA C-terminal domain-like	1	1
Glutamine synthetase/guanido kinase	GAD domain-like	1	1
Nucleic acid-binding proteins	Homing endonucleases	1	1
Hedgehog/intein (Hint) domain	DNA/RNA polymerases	1	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	1	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
NAD(P)-binding Rossmann-fold domains	Glutathione synthetase ATP-binding domain-like	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
tRNA-intron endonuclease catalytic domain-like	tRNA-intron endonuclease catalytic domain-like	1	1
NosL/MerB-like	Pectin lyase-like	1	1
Periplasmic binding protein-like II	GlnB-like	1	1
Hedgehog/intein (Hint) domain	P-loop containing nucleoside triphosphate hydrolases	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	1	1
Class II aaRS and biotin synthetases	C-terminal domain of transcriptional repressors	1	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	1	1
Myosin rod fragments	Smc hinge domain	1	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	1	1
CBS-domain pair	ParB/Sulfiredoxin	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
Ribokinase-like	AraD/HMP-PK domain-like	1	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	1	1
"Winged helix" DNA-binding domain	Restriction endonuclease-like	1	1
"Winged helix" DNA-binding domain	MOP-like	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Nucleic acid-binding proteins	lambda repressor-like DNA-binding domains	1	1
tRNA-intron endonuclease N-terminal domain-like	tRNA-intron endonuclease N-terminal domain-like	1	1
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	Nitrous oxide reductase, N-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Chelatase	Thioredoxin-like	1	1
AN1-like Zinc finger	Rhomboid-like	1	1
CheY-like	Methylesterase CheB, C-terminal domain	1	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	1	1
Nucleic acid-binding proteins	Hedgehog/intein (Hint) domain	1	1
Serine metabolism enzymes domain	ACT-like	1	1
Nucleic acid-binding proteins	RuvA domain 2-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HprK N-terminal domain-like	1	1
Nucleic acid-binding proteins	Ribonuclease H-like	1	1
Thioredoxin-like	FAD/NAD(P)-binding domain	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Nucleic acid-binding proteins	1	1
MurD-like peptide ligases, peptide-binding domain	Dihydropteroate synthetase-like	1	1
PA domain	Zn-dependent exopeptidases	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
Homing endonucleases	lambda repressor-like DNA-binding domains	1	1
Periplasmic binding protein-like II	ACT-like	1	1
"Winged helix" DNA-binding domain	Riboflavin kinase-like	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
tRNA-guanine transglycosylase	Uracil-DNA glycosylase-like	1	1
TGS-like	Class II aaRS ABD-related	1	1
Galactose-binding domain-like	(Trans)glycosidases	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Iron-dependent repressor protein, dimerization domain	C-terminal domain of transcriptional repressors	1	1
DNA polymerase beta, N-terminal domain-like	Sec63 N-terminal domain-like	1	1
Hypothetical protein AF0491, middle domain	EF-G C-terminal domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	1	1
DNA polymerase beta, N-terminal domain-like	PHP domain-like	1	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	1	1
Histidine-containing phosphotransfer domain, HPT domain	CheW-like	1	1
Cupredoxins	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1

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