Domain combination pairs in Mycobacterium indicus pranii MTCC 9506

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

653 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	86	6
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	81	6
Thiolase-like	Thiolase-like	40	7
GroES-like	NAD(P)-binding Rossmann-fold domains	39	6
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	29	15
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	23	6
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	19	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	17	2
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	16	6
CoA-dependent acyltransferases	CoA-dependent acyltransferases	16	11
ISP domain	Bet v1-like	15	3
Acetyl-CoA synthetase-like	ACP-like	15	12
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	13	4
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	13	6
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	13	3
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	13	2
CoA-dependent acyltransferases	Acetyl-CoA synthetase-like	12	10
CoA-dependent acyltransferases	ACP-like	12	10
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	12	4
ACP-like	NAD(P)-binding Rossmann-fold domains	12	8
Calcium ATPase, transduction domain A	HAD-like	11	5
ACP-like	ACP-like	11	10
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	11	5
Homeodomain-like	Homeodomain-like	11	6
P-loop containing nucleoside triphosphate hydrolases	C-terminal effector domain of the bipartite response regulators	11	5
HAD-like	Calcium ATPase, transmembrane domain M	11	5
Actin-like ATPase domain	Actin-like ATPase domain	10	3
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	10	7
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	10	3
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	10	6
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	10	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	FAD/NAD(P)-binding domain	10	3
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	10	4
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	9	3
ClpP/crotonase	ClpP/crotonase	9	3
Ferredoxin reductase-like, C-terminal NADP-linked domain	2Fe-2S ferredoxin-like	9	2
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	9	6
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	9	1
ACP-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	9	6
Riboflavin synthase domain-like	2Fe-2S ferredoxin-like	9	2
ACP-like	FabD/lysophospholipase-like	9	6
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	9	4
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	8	5
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	8	1
Sigma3 and sigma4 domains of RNA polymerase sigma factors	NTF2-like	8	1
Thiolase-like	FabD/lysophospholipase-like	8	6
Sigma2 domain of RNA polymerase sigma factors	NTF2-like	8	1
"Winged helix" DNA-binding domain	GAF domain-like	8	1
"Winged helix" DNA-binding domain	GntR ligand-binding domain-like	8	2
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	7	2
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	7	6
HAMP domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	7	1
ACP-like	Thiolase-like	7	5
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	7	4
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	7	4
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	7	4
GroES-like	GroES-like	7	2
PreATP-grasp domain	Rudiment single hybrid motif	7	4
CheY-like	C-terminal effector domain of the bipartite response regulators	7	1
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	7	5
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	7	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	7	5
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	7	3
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	6	1
CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	6	1
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	6	5
Thiolase-like	NAD(P)-binding Rossmann-fold domains	6	4
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	6	1
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	6	5
P-loop containing nucleoside triphosphate hydrolases	TPR-like	6	6
Rudiment single hybrid motif	Single hybrid motif	5	3
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	5	2
(Trans)glycosidases	Glycosyl hydrolase domain	5	4
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	5	5
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	5	1
SMAD/FHA domain	P-loop containing nucleoside triphosphate hydrolases	5	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	5	3
Thiolase-like	GroES-like	5	3
HAMP domain-like	Nucleotide cyclase	5	1
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	5	1
FabD/lysophospholipase-like	GroES-like	5	3
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	5	4
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	5	1
GroES-like	ACP-like	5	3
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	5	3
PreATP-grasp domain	Single hybrid motif	5	3
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	5	3
GAF domain-like	CheY-like	5	2
SMAD/FHA domain	SMAD/FHA domain	5	1
Nucleotide cyclase	TPR-like	4	4
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	4	2
EF-G C-terminal domain-like	EF-G C-terminal domain-like	4	2
E set domains	(Trans)glycosidases	4	3
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	4	1
Translation proteins	EF-G C-terminal domain-like	4	2
PurM N-terminal domain-like	PurM C-terminal domain-like	4	2
PLP-binding barrel	Alanine racemase C-terminal domain-like	4	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	4	2
Class I glutamine amidotransferase-like	Homeodomain-like	4	1
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	4	4
Nucleotide cyclase	P-loop containing nucleoside triphosphate hydrolases	4	4
NAD(P)-binding Rossmann-fold domains	TrkA C-terminal domain-like	4	2
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	4	3
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	4	4
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	4	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	4
P-loop containing nucleoside triphosphate hydrolases	MOP-like	4	2
Cupredoxins	Cupredoxins	4	2
TPR-like	C-terminal effector domain of the bipartite response regulators	4	4
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	4	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	4	1
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	3
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	3	3
E set domains	Glycosyl hydrolase domain	3	2
Nucleic acid-binding proteins	Nucleic acid-binding proteins	3	3
L30e-like	alpha/beta knot	3	1
Nucleotide cyclase	C-terminal effector domain of the bipartite response regulators	3	3
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	3	1
Transmembrane di-heme cytochromes	Oxidoreductase molybdopterin-binding domain	3	2
Thiolase-like	Nucleic acid-binding proteins	3	2
PYP-like sensor domain (PAS domain)	CheY-like	3	1
GAF domain-like	Nucleotide cyclase	3	2
Aldolase	post-HMGL domain-like	3	3
cAMP-binding domain-like	"Winged helix" DNA-binding domain	3	1
PP2C-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	3	3
P-loop containing nucleoside triphosphate hydrolases	Restriction endonuclease-like	3	2
Acetyl-CoA synthetase-like	alpha/beta-Hydrolases	3	3
Single hybrid motif	CoA-dependent acyltransferases	3	3
ACT-like	ACT-like	3	3
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	3	2
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	3	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	3	2
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	3	1
ACP-like	alpha/beta-Hydrolases	3	3
"Winged helix" DNA-binding domain	Chorismate lyase-like	3	1
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	3	3
TPR-like	TPR-like	3	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	3	2
Nucleotide cyclase	EAL domain-like	3	2
MgtE N-terminal domain-like	CBS-domain pair	3	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	3	1
Trypsin-like serine proteases	PDZ domain-like	3	2
CoA-dependent acyltransferases	alpha/beta-Hydrolases	2	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	2	2
"Winged helix" DNA-binding domain	PLP-dependent transferases	2	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	2	2
NTF2-like	NTF2-like	2	2
Acetyl-CoA synthetase-like	S-adenosyl-L-methionine-dependent methyltransferases	2	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	2	2
Protein kinase-like (PK-like)	Thioredoxin-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	2	2
Single hybrid motif	Single hybrid motif	2	2
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	2	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	2	2
Nucleic acid-binding proteins	RuvA domain 2-like	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	2	1
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	2	2
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	2	2
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	2	1
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	2	2
Translation proteins	Ribosomal protein S5 domain 2-like	2	1
GroEL equatorial domain-like	GroEL apical domain-like	2	2
CBS-domain pair	FAD-binding/transporter-associated domain-like	2	1
tRNA-binding arm	Class II aaRS and biotin synthetases	2	1
MurCD N-terminal domain	MurD-like peptide ligases, catalytic domain	2	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	2	2
Sm-like ribonucleoproteins	cAMP-binding domain-like	2	1
Nucleotide-binding domain	Nucleotide-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	2	2
Iron-dependent repressor protein, dimerization domain	C-terminal domain of transcriptional repressors	2	1
Acyl-CoA N-acyltransferases (Nat)	SCP-like	2	2
Phospholipase D/nuclease	Phospholipase D/nuclease	2	2
Translation proteins SH3-like domain	Nucleic acid-binding proteins	2	2
FabD/lysophospholipase-like	FabD/lysophospholipase-like	2	2
HMA, heavy metal-associated domain	HAD-like	2	1
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	2	1
Lysozyme-like	beta-lactamase/transpeptidase-like	2	2
CoA-dependent acyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	2	2
NAD(P)-binding Rossmann-fold domains	ACT-like	2	2
NAD(P)-binding Rossmann-fold domains	Voltage-gated potassium channels	2	2
HD-domain/PDEase-like	ACT-like	2	2
lambda repressor-like DNA-binding domains	RmlC-like cupins	2	1
"Winged helix" DNA-binding domain	C-terminal domain of transcriptional repressors	2	1
Alpha-L RNA-binding motif	Pseudouridine synthase	2	1
CoA-dependent acyltransferases	NAD(P)-binding Rossmann-fold domains	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	2	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	2	2
Flavoproteins	Riboflavin synthase domain-like	2	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	2	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	2	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	2	2
Resolvase-like	Homeodomain-like	2	1
FMN-linked oxidoreductases	Nucleotide-binding domain	2	2
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	1
MurCD N-terminal domain	MurD-like peptide ligases, peptide-binding domain	2	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	2	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	1
alpha/beta-Hydrolases	NAD(P)-binding Rossmann-fold domains	2	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	2	1
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	2	2
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	2	1
Nucleotidyltransferase	ACT-like	2	2
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	2	2
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	2	1
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	2	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	2
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like I	2	1
ACP-like	S-adenosyl-L-methionine-dependent methyltransferases	2	2
S-adenosyl-L-methionine-dependent methyltransferases	alpha/beta-Hydrolases	2	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	2	1
PA domain	Zn-dependent exopeptidases	2	1
alpha/beta-Hydrolases	Galactose-binding domain-like	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	2	1
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	2	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	2	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	2	1
FMN-binding split barrel	UbiD C-terminal domain-like	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	2	2
4Fe-4S ferredoxins	Nucleotide-binding domain	2	2
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	2	2
GAF domain-like	EAL domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	2
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	2	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	2	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	2	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	2	1
"Winged helix" DNA-binding domain	Iron-dependent repressor protein, dimerization domain	2	1
Nucleotidyltransferase	HD-domain/PDEase-like	2	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	2	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
Inosine monophosphate dehydrogenase (IMPDH)	NAD(P)-binding Rossmann-fold domains	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Fe-S cluster assembly (FSCA) domain-like	ISP domain	1	1
GIY-YIG endonuclease	C-terminal UvrC-binding domain of UvrB	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	CBS-domain pair	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Galactose oxidase, central domain	Kelch motif	1	1
UROD/MetE-like	UROD/MetE-like	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Adenine nucleotide alpha hydrolases-like	MesJ substrate recognition domain-like	1	1
Metallo-hydrolase/oxidoreductase	ISP domain	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
Nucleic acid-binding proteins	Putative DNA-binding domain	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
Tetrapyrrole methylase	Tetrapyrrole methylase	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	Flavoproteins	1	1
HAD-like	Glycerol-3-phosphate (1)-acyltransferase	1	1
Homeodomain-like	Ribonuclease H-like	1	1
Sm-like ribonucleoproteins	Mechanosensitive channel protein MscS (YggB), C-terminal domain	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
NAD(P)-binding Rossmann-fold domains	Tetrapyrrole methylase	1	1
Periplasmic binding protein-like II	ACT-like	1	1
Translation proteins	PRC-barrel domain	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
Hedgehog/intein (Hint) domain	Homing endonucleases	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	ARM repeat	1	1
Protein kinase-like (PK-like)	TPR-like	1	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	1	1
Bet v1-like	NAD(P)-binding Rossmann-fold domains	1	1
Putative DNA-binding domain	Anticodon-binding domain of PheRS	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
P-loop containing nucleoside triphosphate hydrolases	NTF2-like	1	1
FabD/lysophospholipase-like	alpha/beta-Hydrolases	1	1
Molybdenum cofactor biosynthesis proteins	CinA-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	1	1
Periplasmic binding protein-like II	MetI-like	1	1
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	1	1
Zinc beta-ribbon	DNA primase core	1	1
Protein kinase-like (PK-like)	NHL repeat	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Thiamin diphosphate-binding fold (THDP-binding)	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	1	1
Nucleotide-diphospho-sugar transferases	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
Heme-dependent peroxidases	Heme-dependent peroxidases	1	1
Folate-binding domain	Aminomethyltransferase beta-barrel domain	1	1
PPK N-terminal domain-like	Phospholipase D/nuclease	1	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	1	1
CoA-dependent acyltransferases	Thiamin diphosphate-binding fold (THDP-binding)	1	1
5' to 3' exonuclease, C-terminal subdomain	DNA/RNA polymerases	1	1
YjeF N-terminal domain-like	Ribokinase-like	1	1
ADC-like	Riboflavin synthase domain-like	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
lambda repressor-like DNA-binding domains	Phospholipase D/nuclease	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
GroEL equatorial domain-like	GroEL-intermediate domain like	1	1
Ribonuclease H-like	GIY-YIG endonuclease	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
Adenine nucleotide alpha hydrolases-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	1	1
ADC-like	Flavoproteins	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Transcription factor NusA, N-terminal domain	Nucleic acid-binding proteins	1	1
Homeodomain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	Calcium-dependent phosphotriesterase	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
PIN domain-like	Ribonuclease H-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
Aldolase	Single hybrid motif	1	1
FAD/NAD(P)-binding domain	GlcG-like	1	1
Nucleic acid-binding proteins	Anticodon-binding domain of PheRS	1	1
Rudiment single hybrid motif	post-HMGL domain-like	1	1
YrdC/RibB	RibA-like	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
Acid phosphatase/Vanadium-dependent haloperoxidase	NAD kinase/diacylglycerol kinase-like	1	1
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	1	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	1	1
Formyltransferase	FMT C-terminal domain-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	1	1
Prim-pol domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Single hybrid motif	ClpP/crotonase	1	1
HemD-like	C-terminal effector domain of the bipartite response regulators	1	1
PP2C-like	SpoIIaa-like	1	1
FabD/lysophospholipase-like	Inosine monophosphate dehydrogenase (IMPDH)	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	1	1
FAD/NAD(P)-binding domain	ARM repeat	1	1
Tetracyclin repressor-like, C-terminal domain	Thioesterase/thiol ester dehydrase-isomerase	1	1
TPR-like	NTF2-like	1	1
Carbamate kinase-like	PUA domain-like	1	1
Riboflavin synthase domain-like	ABC transporter transmembrane region	1	1
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
DNA topoisomerase I domain	DNA breaking-rejoining enzymes	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Nucleotidylyl transferase	Riboflavin kinase-like	1	1
Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	1	1
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	1	1
N-terminal domain of DnaB helicase	Homing endonucleases	1	1
Class II aaRS and biotin synthetases	YbaK/ProRS associated domain	1	1
Penicillin binding protein dimerisation domain	beta-lactamase/transpeptidase-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
Ribonuclease H-like	Phosphoglycerate mutase-like	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
Alpha-L RNA-binding motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	1	1
PheT/TilS domain	Putative DNA-binding domain	1	1
Ribonuclease H-like	DNA/RNA polymerases	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Ribonuclease H-like	HRDC-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Nucleotidyltransferase	1	1
Nucleic acid-binding proteins	PheT/TilS domain	1	1
post-HMGL domain-like	Single hybrid motif	1	1
PUA domain-like	alpha/beta knot	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
HD-domain/PDEase-like	C-terminal effector domain of the bipartite response regulators	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
NAD(P)-binding Rossmann-fold domains	Phosphohistidine domain	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
FabD/lysophospholipase-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	1	1
HAD-like	HAD-like	1	1
Nucleotidylyl transferase	tRNA-binding arm	1	1
PRC-barrel domain	CBS-domain pair	1	1
GlnB-like	GlnB-like	1	1
PK beta-barrel domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
HIT-like	HIT-like	1	1
PheT/TilS domain	Anticodon-binding domain of PheRS	1	1
DNA clamp	DNA clamp	1	1
Nucleotidyltransferase	TGS-like	1	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	1	1
Protein kinase-like (PK-like)	AttH-like	1	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
RNase III domain-like	dsRNA-binding domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	1	1
RuvA domain 2-like	DNA helicase RuvA subunit, C-terminal domain	1	1
Nucleotidyltransferase	Nucleotidyltransferase substrate binding subunit/domain	1	1
Cytochrome c	Cytochrome c	1	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	1	1
GntR ligand-binding domain-like	GntR ligand-binding domain-like	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	SpoIIaa-like	1	1
Translation proteins	Translation proteins	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
SIS domain	HupF/HypC-like	1	1
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	1	1
F1F0 ATP synthase subunit B, membrane domain	N-terminal domain of the delta subunit of the F1F0-ATP synthase	1	1
Homeodomain-like	TATA-box binding protein-like	1	1
DNA polymerase beta, N-terminal domain-like	PHP domain-like	1	1
PreATP-grasp domain	Aldolase	1	1
Acyl-CoA N-acyltransferases (Nat)	Glutathione synthetase ATP-binding domain-like	1	1
GroEL equatorial domain-like	GroEL equatorial domain-like	1	1
Inosine monophosphate dehydrogenase (IMPDH)	Thioesterase/thiol ester dehydrase-isomerase	1	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	1	1
Tetrapyrrole methylase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PreATP-grasp domain	post-HMGL domain-like	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	1	1
GreA transcript cleavage protein, N-terminal domain	FKBP-like	1	1
YbaK/ProRS associated domain	Class II aaRS ABD-related	1	1
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	1	1
C-terminal effector domain of the bipartite response regulators	NTF2-like	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
cAMP-binding domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
P-loop containing nucleoside triphosphate hydrolases	HprK N-terminal domain-like	1	1
Nucleotidyltransferase	Nucleotidyltransferase	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RuvA domain 2-like	1	1
Cytidine deaminase-like	Dihydrofolate reductase-like	1	1
Metallo-hydrolase/oxidoreductase	SCP-like	1	1
ParB/Sulfiredoxin	KorB DNA-binding domain-like	1	1
Kelch motif	Kelch motif	1	1
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	1	1
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	1	1
Oxidoreductase molybdopterin-binding domain	E set domains	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
FMN-linked oxidoreductases	FAD/NAD(P)-binding domain	1	1
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	1	1
PRC-barrel domain	MgtE N-terminal domain-like	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
Ribonuclease H-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Inosine monophosphate dehydrogenase (IMPDH)	Thiolase-like	1	1
Phospholipase D/nuclease	P-loop containing nucleoside triphosphate hydrolases	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	MFS general substrate transporter	1	1
Nudix	Phosphoglycerate mutase-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Nucleic acid-binding proteins	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	1	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
ADC-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
5' to 3' exonuclease, C-terminal subdomain	Ribonuclease H-like	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Nucleic acid-binding proteins	Prokaryotic type KH domain (KH-domain type II)	1	1
Tetrapyrrole methylase	HemD-like	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
HprK N-terminal domain-like	Isocitrate/Isopropylmalate dehydrogenase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	CarD-like	1	1
Nucleotide cyclase	NTF2-like	1	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
YajQ-like	YajQ-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Isocitrate/Isopropylmalate dehydrogenase-like	1	1
Nudix	"Winged helix" DNA-binding domain	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
TSP type-3 repeat	TSP type-3 repeat	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	P-loop containing nucleoside triphosphate hydrolases	1	1
Translation proteins	Initiation factor IF2/eIF5b, domain 3	1	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	1	1
Glutathione synthetase ATP-binding domain-like	Aldolase	1	1
Nucleotide-binding domain	FAD/NAD(P)-binding domain	1	1
PreATP-grasp domain	PreATP-grasp domain	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
Protein kinase-like (PK-like)	Kelch motif	1	1
Type II DNA topoisomerase	Acyl-CoA N-acyltransferases (Nat)	1	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Dihydropteroate synthetase-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
PDZ domain-like	Ribosomal protein S5 domain 2-like	1	1
Carbamate kinase-like	ACT-like	1	1
PUA domain-like	Ribosomal protein S5 domain 2-like	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	1	1
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	1	1
2Fe-2S ferredoxin-like	ADC-like	1	1
FKBP-like	Triger factor/SurA peptide-binding domain-like	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
"Winged helix" DNA-binding domain	Actin-like ATPase domain	1	1
Thioesterase/thiol ester dehydrase-isomerase	Nucleic acid-binding proteins	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
FAD/NAD(P)-binding domain	ISP domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
Nucleotidyltransferase substrate binding subunit/domain	Nucleotidyltransferase substrate binding subunit/domain	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	DNA-glycosylase	1	1
post-HMGL domain-like	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
CheY-like	FAD/NAD(P)-binding domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
"Winged helix" DNA-binding domain	LexA/Signal peptidase	1	1
E set domains	E set domains	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
YhbC-like, N-terminal domain	YhbC-like, C-terminal domain	1	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	1	1
Rudiment single hybrid motif	Aldolase	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	TATA-box binding protein-like	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	1	1
CarD-like	TRCF domain-like	1	1
Nucleic acid-binding proteins	DNA helicase RuvA subunit, C-terminal domain	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Galactose oxidase, central domain	Galactose oxidase, central domain	1	1
GIY-YIG endonuclease	RuvA domain 2-like	1	1
PYP-like sensor domain (PAS domain)	PP2C-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
PIN domain-like	DNA/RNA polymerases	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
"Winged helix" DNA-binding domain	C-terminal domain of arginine repressor	1	1
Radical SAM enzymes	Radical SAM enzymes	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	1	1
YojJ-like	RuvA domain 2-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	1	1
alpha-helical ferredoxin	Nucleotide-binding domain	1	1
cAMP-binding domain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
PIN domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
FAD/NAD(P)-binding domain	Nitrite/Sulfite reductase N-terminal domain-like	1	1
Thiolase-like	alpha/beta-Hydrolases	1	1
PK beta-barrel domain-like	2Fe-2S ferredoxin-like	1	1
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	1	1
HD-domain/PDEase-like	TGS-like	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	Riboflavin synthase domain-like	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	TK C-terminal domain-like	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Activating enzymes of the ubiquitin-like proteins	FMN-dependent nitroreductase-like	1	1
PH0987 N-terminal domain-like	Cyclophilin-like	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
TGS-like	ACT-like	1	1
Nucleic acid-binding proteins	ArfGap/RecO-like zinc finger	1	1
Prokaryotic type KH domain (KH-domain type II)	Prokaryotic type KH domain (KH-domain type II)	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
CofE-like	FMN-dependent nitroreductase-like	1	1
Aspartate/glutamate racemase	Aspartate/glutamate racemase	1	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Homeodomain-like	DNA-glycosylase	1	1
ACT-like	HAD-like	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	1	1
FAD/NAD(P)-binding domain	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
GroEL-intermediate domain like	GroEL apical domain-like	1	1
Nucleotide-diphospho-sugar transferases	Duplicated hybrid motif	1	1
Pseudouridine synthase	PUA domain-like	1	1
Periplasmic binding protein-like II	GlnB-like	1	1
PK beta-barrel domain-like	Riboflavin synthase domain-like	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
DinB/YfiT-like putative metalloenzymes	C-type lectin-like	1	1
Calcium-dependent phosphotriesterase	Calcium-dependent phosphotriesterase	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
Trigger factor ribosome-binding domain	FKBP-like	1	1
Thioesterase/thiol ester dehydrase-isomerase	NAD(P)-binding Rossmann-fold domains	1	1
alpha/beta-Hydrolases	Nucleotide cyclase	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
"Winged helix" DNA-binding domain	SCP-like	1	1
Serine metabolism enzymes domain	ACT-like	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
GAF domain-like	GAF domain-like	1	1
N-terminal domain of DnaB helicase	P-loop containing nucleoside triphosphate hydrolases	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Thioesterase/thiol ester dehydrase-isomerase	Thiolase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal UvrC-binding domain of UvrB	1	1
FAH	Metallo-hydrolase/oxidoreductase	1	1
Acylphosphatase/BLUF domain-like	YrdC/RibB	1	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
RmlC-like cupins	Homeodomain-like	1	1
4Fe-4S ferredoxins	ADC-like	1	1
Galactose mutarotase-like	Six-hairpin glycosidases	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
PPK N-terminal domain-like	PHP14-like	1	1
Globin-like	Riboflavin synthase domain-like	1	1
Galactose-binding domain-like	Galactose-binding domain-like	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	ACT-like	1	1
GAF domain-like	PP2C-like	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	1	1
Transcription factor NusA, N-terminal domain	Prokaryotic type KH domain (KH-domain type II)	1	1
N-terminal domain of DnaB helicase	Hedgehog/intein (Hint) domain	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
Globin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Hedgehog/intein (Hint) domain	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	CoaB-like	1	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	1	1
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	1	1
FAD-binding/transporter-associated domain-like	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Homing endonucleases	1	1
PHP14-like	Phospholipase D/nuclease	1	1
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	1	1
Adenine nucleotide alpha hydrolases-like	Homodimeric domain of signal transducing histidine kinase	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	TrpR-like	1	1
Thioredoxin-like	GST C-terminal domain-like	1	1
RuvA domain 2-like	BRCT domain	1	1
Riboflavin synthase domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleotide cyclase	Nucleotide cyclase	1	1
Protein kinase-like (PK-like)	Galactose oxidase, central domain	1	1
Voltage-gated potassium channels	TrkA C-terminal domain-like	1	1
Heme-dependent catalase-like	Class I glutamine amidotransferase-like	1	1
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	1	1

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