|
|
Oxidoreductases
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Dihydropteroate synthetase-like | 0 | DIRECT |
| Hemocyanin, N-terminal domain | 0 | DIRECT |
| Globin-like | 0 | DIRECT |
| HydB/Nqo4-like | 0 | DIRECT |
| Cytochrome c oxidase subunit I-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | DIRECT |
| Thioredoxin-like | 0 | DIRECT |
| ISP transmembrane anchor | 0 | DIRECT |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | DIRECT |
| Heme oxygenase-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| FMN-dependent nitroreductase-like | 0 | DIRECT |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
| Superoxide reductase-like | 0 | DIRECT |
| Prismane protein-like | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0 | DIRECT |
| Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| HydA/Nqo6-like | 0 | DIRECT |
| Frataxin/Nqo15-like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| PFL-like glycyl radical enzymes | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | DIRECT |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Respiratory nitrate reductase 1 gamma chain | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| ParB/Sulfiredoxin | 0 | DIRECT |
| Bacterial luciferase-like | 0 | DIRECT |
| Multiheme cytochromes | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
| Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | DIRECT |
| Aromatic compound dioxygenase | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| "Helical backbone" metal receptor | 0 | DIRECT |
| LigB-like | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| Nqo1C-terminal domain-like | 0 | DIRECT |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
| Nqo5-like | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Nqo1 FMN-binding domain-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Clavaminate synthase-like | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Cytochrome c oxidase subunit III-like | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| alpha-helical ferredoxin | 0 | DIRECT |
| Methylamine dehydrogenase, L chain | 0 | DIRECT |
| Peptide methionine sulfoxide reductase | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
| Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Dihydrofolate reductase-like | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| Nucleotide-binding domain | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Nqo1 middle domain-like | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| PHM/PNGase F | 0.00000000000004427 | DIRECT |
| Non-globular alpha+beta subunits of globular proteins | 0.000000000004856 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.00000000004878 | DIRECT |
| Serine metabolism enzymes domain | 0.000000004694 | DIRECT |
| Rubredoxin-like | 0.0000005276 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.000001049 | DIRECT |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.00001165 | DIRECT |
| NTF2-like | 0.0002027 | DIRECT |
| EGF/Laminin | 0.0002233 | DIRECT |
| HSP20-like chaperones | 0.00119 | INHERITED FROM: Acting on NADH or NADPH || Cytochrome-b5 reductase || With a heme protein as acceptor |
| ACT-like | 0.005559 | INHERITED FROM: Phosphoglycerate dehydrogenase || Prephenate dehydrogenase || Acting on paired donors, with incorporation or red || Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || With reduced pteridine as one donor, and incorpora || With NAD(+) or NADP(+) as acceptor |
| FnI-like domain | 0.007355 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| Nitrous oxide reductase, N-terminal domain | 0.02397 | INHERITED FROM: Acting on other nitrogenous compounds as donors || Nitrous-oxide reductase || With a cytochrome as acceptor |
| ARM repeat | 0.05767 | INHERITED FROM: Acting on paired donors, with incorporation or red || Deoxyhypusine monooxygenase || Miscellaneous (requires further characterization) |
| FYVE/PHD zinc finger | 0.067 | INHERITED FROM: Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || [Histone H3]-lysine-36 demethylase |
| SMAD/FHA domain | 0.1289 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Zeaxanthin epoxidase |
| TPR-like | 0.1413 | INHERITED FROM: Procollagen-proline 3-dioxygenase || Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || Procollagen-proline dioxygenase |
| ACP-like | 0.1608 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || L-aminoadipate-semialdehyde dehydrogenase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the aldehyde or oxo group of donors |
| Dimeric alpha+beta barrel | 0.2323 | INHERITED FROM: Acting on paired donors, with incorporation or red || Miscellaneous (requires further characterization) || Heme oxygenase |
| HMA, heavy metal-associated domain | 0.3102 | INHERITED FROM: Mercury(II) reductase || Oxidizing metal ions || With NAD(+) or NADP(+) as acceptor |
| TK C-terminal domain-like | 0.3443 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || With an iron-sulfur protein as acceptor || Acting on the aldehyde or oxo group of donors |
| RNI-like | 0.4543 | INHERITED FROM: Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || [Histone H3]-lysine-36 demethylase |
| Complement control module/SCR domain | 0.4992 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Iodide peroxidase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7751 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| EPT/RTPC-like | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Immunoglobulin | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: With 2-oxoglutarate as one donor, and incorporatio || Procollagen-lysine 5-dioxygenase |
| E set domains | 1 | INHERITED FROM: Sulfite oxidase || Nitrate reductase (NADH) || With oxygen as acceptor || Acting on other nitrogenous compounds as donors || Nitrate reductase (NADPH) || Monophenol monooxygenase || With NAD(+) or NADP(+) as acceptor || With another compound as one donor, and incorporat |
| EF-hand | 1 | INHERITED FROM: Acting on NADH or NADPH || With a oxygen as acceptor || Glycerol-3-phosphate dehydrogenase || With a quinone or similar compound as acceptor |
| FabD/lysophospholipase-like | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| DHS-like NAD/FAD-binding domain | 1 | INHERITED FROM: NAD(P)(+) transhydrogenase (AB-specific) || With NAD(+) or NADP(+) as acceptor |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: L-aminoadipate-semialdehyde dehydrogenase |
| Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With other acceptors || Acting on the CH-NH group of donors |
| Carbamate kinase-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: With dinitrogen as acceptor || Shikimate dehydrogenase || Thymine dioxygenase || Acting on iron-sulfur proteins as donors |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Catalase |
| Cysteine-rich domain | 1 | INHERITED FROM: Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor || Protein-disulfide reductase |
| ClpP/crotonase | 1 | INHERITED FROM: 3-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| all-alpha NTP pyrophosphatases | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: With incorporation of one atom of oxygen || Photinus-luciferin 4-monooxygenase (ATP-hydrolyzin || L-aminoadipate-semialdehyde dehydrogenase |
| Thiolase-like | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || 3-oxoacyl-[acyl-carrier-protein] reductase |
| Cytidine deaminase-like | 1 | INHERITED FROM: 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| FMT C-terminal domain-like | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || With an iron-sulfur protein as acceptor || Glutamate synthase (NADH) || Acting on the CH-NH(2) group of donors |
| HD-domain/PDEase-like | 1 | INHERITED FROM: Miscellaneous (requires further characterization) || Acting on single donors with incorporation of mole |
| Formyltransferase | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Chloride peroxidase || 3-oxoacyl-[acyl-carrier-protein] reductase |
| Folate-binding domain | 1 | INHERITED FROM: With other acceptors || Acting on the CH-NH group of donors |
| PDZ domain-like | 1 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Nitric-oxide synthase |
| Enolase C-terminal domain-like | 1 | INHERITED FROM: Acting on CH or CH(2) groups || With an iron-sulfur protein as acceptor || (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth |
| GST C-terminal domain-like | 1 | INHERITED FROM: Acting on a sulfur group of donors || Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With disulfide as acceptor || With a quinone or similar compound as acceptor || Methylarsonate reductase |
| Adenine nucleotide alpha hydrolases-like | 1 | INHERITED FROM: Acting on a sulfur group of donors || Phosphoadenylyl-sulfate reductase (thioredoxin) || With a disulfide as acceptor |
| Metallo-hydrolase/oxidoreductase | 1 | INHERITED FROM: CMP-N-acetylneuraminate monooxygenase || With another compound as one donor, and incorporat |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | INHERITED FROM: Dihydrofolate reductase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor |
| PLP-dependent transferases | 1 | INHERITED FROM: Acting on the CH-NH(2) group of donors || With a disulfide as acceptor |
| Radical SAM enzymes | 1 | INHERITED FROM: With other acceptors || Coproporphyrinogen dehydrogenase || [Formate-C-acetyltransferase]-activating enzyme |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
| L domain-like | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| Ubiquitin-like | 1 | INHERITED FROM: Trans-2-enoyl-CoA reductase (NADPH) || With NAD(+) or NADP(+) as acceptor |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Dihydropteroate synthetase-like | 0 | Direct |
| Hemocyanin, N-terminal domain | 0 | Direct |
| Globin-like | 0 | Direct |
| HydB/Nqo4-like | 0 | Direct |
| Cytochrome c oxidase subunit I-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | Direct |
| Thioredoxin-like | 0 | Direct |
| ISP transmembrane anchor | 0 | Direct |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | Direct |
| Heme oxygenase-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| FMN-dependent nitroreductase-like | 0 | Direct |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
| Superoxide reductase-like | 0 | Direct |
| Prismane protein-like | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0 | Direct |
| Oxidoreductase molybdopterin-binding domain | 0 | Direct |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| HydA/Nqo6-like | 0 | Direct |
| Frataxin/Nqo15-like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| PFL-like glycyl radical enzymes | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | Direct |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Respiratory nitrate reductase 1 gamma chain | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| ParB/Sulfiredoxin | 0 | Direct |
| Bacterial luciferase-like | 0 | Direct |
| Multiheme cytochromes | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
| Photosystem I subunits PsaA/PsaB | 0 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | Direct |
| Aromatic compound dioxygenase | 0 | Direct |
| GroES-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| "Helical backbone" metal receptor | 0 | Direct |
| LigB-like | 0 | Direct |
| FAD-linked oxidoreductase | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| Nqo1C-terminal domain-like | 0 | Direct |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
| Nqo5-like | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| Nqo1 FMN-binding domain-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Clavaminate synthase-like | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| ADC-like | 0 | Direct |
| Cytochrome c oxidase subunit III-like | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| alpha-helical ferredoxin | 0 | Direct |
| Methylamine dehydrogenase, L chain | 0 | Direct |
| Peptide methionine sulfoxide reductase | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| AhpD-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
| Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| NAD(P)-binding Rossmann-fold domains | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Dihydrofolate reductase-like | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| Nucleotide-binding domain | 0 | Direct |
| Flavoproteins | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| Bet v1-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Nqo1 middle domain-like | 0 | Direct |
| ISP domain | 0 | Direct |
| Mss4-like | 0 | Direct |
| PHM/PNGase F | 0.00000000000004427 | Direct |
| Non-globular alpha+beta subunits of globular proteins | 0.000000000004856 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.00000000004878 | Direct |
| Serine metabolism enzymes domain | 0.000000004694 | Direct |
| Rubredoxin-like | 0.0000005276 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0.000001049 | Direct |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.00001165 | Direct |
| NTF2-like | 0.0002027 | Direct |
| EGF/Laminin | 0.0002233 | Direct |
| HSP20-like chaperones | 0.00119 | Inherited |
| ACT-like | 0.005559 | Inherited |
| FnI-like domain | 0.007355 | Inherited |
| Nitrous oxide reductase, N-terminal domain | 0.02397 | Inherited |
| ARM repeat | 0.05767 | Inherited |
| FYVE/PHD zinc finger | 0.067 | Inherited |
| SMAD/FHA domain | 0.1289 | Inherited |
| TPR-like | 0.1413 | Inherited |
| ACP-like | 0.1608 | Inherited |
| Dimeric alpha+beta barrel | 0.2323 | Inherited |
| HMA, heavy metal-associated domain | 0.3102 | Inherited |
| TK C-terminal domain-like | 0.3443 | Inherited |
| RNI-like | 0.4543 | Inherited |
| Complement control module/SCR domain | 0.4992 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7751 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| E set domains | 1 | Inherited |
| EF-hand | 1 | Inherited |
| FabD/lysophospholipase-like | 1 | Inherited |
| DHS-like NAD/FAD-binding domain | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Aminomethyltransferase beta-barrel domain | 1 | Inherited |
| Carbamate kinase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| HisI-like | 1 | Inherited |
| Aldolase | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| Cysteine-rich domain | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| all-alpha NTP pyrophosphatases | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| Cytidine deaminase-like | 1 | Inherited |
| FMT C-terminal domain-like | 1 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| Folate-binding domain | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| Enolase C-terminal domain-like | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| Adenine nucleotide alpha hydrolases-like | 1 | Inherited |
| Metallo-hydrolase/oxidoreductase | 1 | Inherited |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Radical SAM enzymes | 1 | Inherited |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | Inherited |
| L domain-like | 1 | Inherited |
| Ubiquitin-like | 1 | Inherited |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Acireductone dioxygenase | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| PHBH-like | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Tyrosine-dependent oxidoreductases | 0 | DIRECT |
| ETF-QO domain-like | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0 | DIRECT |
| Electron transfer flavoprotein-ubiquinone oxidoreductase-like | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| PNP-oxidase like | 0 | DIRECT |
| Respiratory nitrate reductase 1 gamma chain | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| Frataxin-like | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| CCP-like | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| DsrA/DsrB N-terminal-domain-like | 0 | DIRECT |
| Aromatic compound dioxygenase | 0 | DIRECT |
| Globins | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| PAPS reductase-like | 0 | DIRECT |
| PqqC-like | 0 | DIRECT |
| Extradiol dioxygenases | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| Pirin-like | 0 | DIRECT |
| SerA intervening domain-like | 0 | DIRECT |
| Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| F420 dependent oxidoreductases | 0 | DIRECT |
| Methylenetetrahydrofolate reductase | 0 | DIRECT |
| Catalase-peroxidase KatG | 0 | DIRECT |
| Oxygen-independent coproporphyrinogen III oxidase HemN | 0 | DIRECT |
| Aromatic dioxygenase reductase-like | 0 | DIRECT |
| Rieske iron-sulfur protein (ISP) | 0 | DIRECT |
| Arthropod hemocyanin, C-terminal domain | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase dimerisation domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Hemocyanin, N-terminal domain | 0 | DIRECT |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | DIRECT |
| L-alanine dehydrogenase-like | 0 | DIRECT |
| Nqo1 FMN-binding domain-like | 0 | DIRECT |
| Eukaryotic type heme oxygenase | 0 | DIRECT |
| 7-Fe ferredoxin | 0 | DIRECT |
| Glycerol-3-phosphate dehydrogenase | 0 | DIRECT |
| FAD-linked oxidases, N-terminal domain | 0 | DIRECT |
| NADH:FMN oxidoreductase-like | 0 | DIRECT |
| Catalase, C-terminal domain | 0 | DIRECT |
| Desulforedoxin | 0 | DIRECT |
| Penicillin synthase-like | 0 | DIRECT |
| Nqo5-like | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| C1-like domain | 0 | DIRECT |
| Dihydrodipicolinate reductase-like | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| Ubiquinol-cytochrome c reductase 8 kDa protein | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Thioltransferase | 0 | DIRECT |
| ArsC-like | 0 | DIRECT |
| 3-hydroxyanthranilic acid dioxygenase-like | 0 | DIRECT |
| PdxA-like | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | DIRECT |
| Periplasmic domain of cytochrome c oxidase subunit II | 0 | DIRECT |
| C-terminal domain of adrenodoxin reductase-like | 0 | DIRECT |
| Ring hydroxylating beta subunit | 0 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | DIRECT |
| Flavohemoglobin, C-terminal domain | 0 | DIRECT |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain | 0 | DIRECT |
| Cytochrome c oxidase subunit III-like | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, C-terminal domain | 0 | DIRECT |
| Methylamine dehydrogenase, L chain | 0 | DIRECT |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
| Bacterial tryptophan 2,3-dioxygenase | 0 | DIRECT |
| Glycine dehydrogenase subunits (GDC-P) | 0 | DIRECT |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | DIRECT |
| Ketopantoate reductase PanE | 0 | DIRECT |
| Superoxide reductase-like | 0 | DIRECT |
| MioX-like | 0 | DIRECT |
| Animal lipoxigenases | 0 | DIRECT |
| Aldo-keto reductases (NADP) | 0 | DIRECT |
| Nickel-iron hydrogenase, small subunit | 0 | DIRECT |
| Aminoacid dehydrogenases | 0 | DIRECT |
| Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
| Homoserine dehydrogenase-like | 0 | DIRECT |
| Quinone reductase | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
| Nqo1 middle domain-like | 0 | DIRECT |
| PhyH-like | 0 | DIRECT |
| SelR domain | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, C-terminal domain | 0 | DIRECT |
| Ring hydroxylating alpha subunit ISP domain | 0 | DIRECT |
| Ribonucleotide reductase-like | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Siroheme synthase N-terminal domain-like | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | DIRECT |
| Dihydrofolate reductases | 0 | DIRECT |
| Nqo4-like | 0 | DIRECT |
| TyrA dimerization domain-like | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| Bacterial luciferase (alkanal monooxygenase) | 0 | DIRECT |
| Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
| N-(1-D-carboxylethyl)-L-norvaline dehydrogenase | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| AhpD | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Homogentisate dioxygenase | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | DIRECT |
| Catechol oxidase | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Cytochrome b5 | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase, C-terminal domain | 0 | DIRECT |
| Duplicated SiR/NiR-like domains 1 and 3 | 0 | DIRECT |
| B12-dependent (class II) ribonucleotide reductase | 0 | DIRECT |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| LigB-like | 0 | DIRECT |
| PFOR PP module | 0 | DIRECT |
| Methylamine dehydrogenase, H-chain | 0 | DIRECT |
| Carbon monoxide dehydrogenase | 0 | DIRECT |
| PG130-like | 0 | DIRECT |
| Proline dehydrohenase domain of bifunctional PutA protein | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| RibD C-terminal domain-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Mannitol 2-dehydrogenase | 0 | DIRECT |
| Ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Glutathione peroxidase-like | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Lipoxigenase N-terminal domain | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| ISP transmembrane anchor | 0 | DIRECT |
| Di-heme elbow motif | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| PFOR Pyr module | 0 | DIRECT |
| Urate oxidase (uricase) | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0 | DIRECT |
| NQO2-like | 0 | DIRECT |
| HMD dimerization domain-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Ssud-like monoxygenases | 0 | DIRECT |
| NADH oxidase/flavin reductase | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) | 0 | DIRECT |
| Sulfiredoxin-like | 0 | DIRECT |
| GMC oxidoreductases | 0 | DIRECT |
| Iron-containing alcohol dehydrogenase | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Nqo1C-terminal domain-like | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| NADPH-dependent FMN reductase | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Hemocyanin middle domain | 0 | DIRECT |
| Cytochrome c oxidase subunit I-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Ring hydroxylating alpha subunit catalytic domain | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | DIRECT |
| Nitrogenase iron-molybdenum protein | 0 | DIRECT |
| Nq06-like | 0 | DIRECT |
| Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain II | 0 | DIRECT |
| Shikimate dehydrogenase-like | 0 | DIRECT |
| L-histidinol dehydrogenase HisD | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| Plant lipoxigenases | 0 | DIRECT |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | DIRECT |
| Peptide methionine sulfoxide reductase | 0 | DIRECT |
| Molybdenum-containing oxidoreductases-like dimerisation domain | 0 | DIRECT |
| Cytokinin dehydrogenase 1 | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| Dihydropyrimidine dehydrogenase, N-terminal domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | DIRECT |
| Nitrosocyanin | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| ProC C-terminal domain-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Nickel-iron hydrogenase, large subunit | 0 | DIRECT |
| Cysteine dioxygenase type I | 0 | DIRECT |
| N-terminal domain of adrenodoxin reductase-like | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | DIRECT |
| Transhydrogenase domain III (dIII) | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Glucose 6-phosphate dehydrogenase-like | 0 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0.000000000007432 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.0000000000227 | DIRECT |
| Germin/Seed storage 7S protein | 0.000009736 | DIRECT |
| Acyl-carrier protein (ACP) | 0.000009863 | DIRECT |
| Haloperoxidase | 0.00005938 | DIRECT |
| Deoxycytidylate deaminase-like | 0.00018 | DIRECT |
| EGF-type module | 0.001093 | INHERITED FROM: Prostaglandin-endoperoxide synthase || Acting on paired donors, with incorporation or red || Miscellaneous (requires further characterization) |
| Aspartokinase allosteric domain-like | 0.001417 | INHERITED FROM: Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| Nitrous oxide reductase, N-terminal domain | 0.002878 | INHERITED FROM: Acting on other nitrogenous compounds as donors || Nitrous-oxide reductase || With a cytochrome as acceptor |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.006412 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| Ornithine cyclodeaminase-like | 0.006412 | INHERITED FROM: Thiomorpholine-carboxylate dehydrogenase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor |
| MaoC-like | 0.006796 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || Acting on the CH-CH group of donors || With NAD(+) or NADP(+) as acceptor |
| Ngr ectodomain-like | 0.01216 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| FabD-like | 0.01463 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| PDZ domain | 0.02756 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Nitric-oxide synthase |
| FHA domain | 0.09997 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Zeaxanthin epoxidase |
| Shikimate kinase (AroK) | 0.1405 | INHERITED FROM: Shikimate dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| Dihydropteroate synthetase | 0.1768 | INHERITED FROM: Acting on CH or CH(2) groups || With an iron-sulfur protein as acceptor || (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth |
| Tetratricopeptide repeat (TPR) | 0.2061 | INHERITED FROM: Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || Procollagen-proline dioxygenase |
| HMA, heavy metal-associated domain | 0.2893 | INHERITED FROM: Mercury(II) reductase || Oxidizing metal ions || With NAD(+) or NADP(+) as acceptor |
| Transketolase C-terminal domain-like | 0.4182 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || Acting on the aldehyde or oxo group of donors |
| Complement control module/SCR domain | 0.4674 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Iodide peroxidase |
| PHD domain | 0.4996 | INHERITED FROM: Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || [Histone H3]-lysine-36 demethylase |
| Calmodulin-like | 0.6008 | INHERITED FROM: Acting on NADH or NADPH || With a oxygen as acceptor |
| Phosphotransacetylase | 0.6469 | INHERITED FROM: Malate dehydrogenase (oxaloacetate-decarboxylating |
| TK-like Pyr module | 0.8924 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || Acting on the aldehyde or oxo group of donors |
| Dehydroquinate synthase, DHQS | 0.9607 | INHERITED FROM: Shikimate dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| Glutathione S-transferase (GST), N-terminal domain | 1 | INHERITED FROM: Acting on a sulfur group of donors || Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With disulfide as acceptor || With a quinone or similar compound as acceptor || Methylarsonate reductase |
| Enolpyruvate transferase, EPT | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Glutathione S-transferase (GST), C-terminal domain | 1 | INHERITED FROM: Acting on a sulfur group of donors || Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With disulfide as acceptor || With a quinone or similar compound as acceptor || Methylarsonate reductase |
| Thiolase-related | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || 3-oxoacyl-[acyl-carrier-protein] reductase |
| Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With other acceptors || Acting on the CH-NH group of donors |
| TK-like PP module | 1 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) |
| Tandem AAA-ATPase domain | 1 | INHERITED FROM: With 2-oxoglutarate as one donor, and incorporatio || Thymine dioxygenase |
| PyrH-like | 1 | INHERITED FROM: Homoserine dehydrogenase || Glutamate-5-semialdehyde dehydrogenase |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 1 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || Acting on the aldehyde or oxo group of donors |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | INHERITED FROM: Dihydrofolate reductase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: With incorporation of one atom of oxygen || Photinus-luciferin 4-monooxygenase (ATP-hydrolyzin || L-aminoadipate-semialdehyde dehydrogenase |
| Formyltransferase | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
| I set domains | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| GTP cyclohydrolase I | 1 | INHERITED FROM: PreQ(1) synthase || Acting on other nitrogenous compounds as donors || With NAD(+) or NADP(+) as acceptor |
| Class II glutamine amidotransferases | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || With an iron-sulfur protein as acceptor || Glutamate synthase (NADH) || Acting on the CH-NH(2) group of donors |
| Post formyltransferase domain | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
| Aminomethyltransferase folate-binding domain | 1 | INHERITED FROM: With other acceptors || Acting on the CH-NH group of donors |
| Class I aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Nitrogenase iron protein-like | 1 | INHERITED FROM: With dinitrogen as acceptor || Acting on iron-sulfur proteins as donors |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Acireductone dioxygenase | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| PHBH-like | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| GAPDH-like | 0 | Direct |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Tyrosine-dependent oxidoreductases | 0 | Direct |
| ETF-QO domain-like | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0 | Direct |
| Electron transfer flavoprotein-ubiquinone oxidoreductase-like | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| PNP-oxidase like | 0 | Direct |
| Respiratory nitrate reductase 1 gamma chain | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Crotonase-like | 0 | Direct |
| Frataxin-like | 0 | Direct |
| Ferritin | 0 | Direct |
| CCP-like | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| DsrA/DsrB N-terminal-domain-like | 0 | Direct |
| Aromatic compound dioxygenase | 0 | Direct |
| Globins | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| PAPS reductase-like | 0 | Direct |
| PqqC-like | 0 | Direct |
| Extradiol dioxygenases | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| Pirin-like | 0 | Direct |
| SerA intervening domain-like | 0 | Direct |
| Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| F420 dependent oxidoreductases | 0 | Direct |
| Methylenetetrahydrofolate reductase | 0 | Direct |
| Catalase-peroxidase KatG | 0 | Direct |
| Oxygen-independent coproporphyrinogen III oxidase HemN | 0 | Direct |
| Aromatic dioxygenase reductase-like | 0 | Direct |
| Rieske iron-sulfur protein (ISP) | 0 | Direct |
| Arthropod hemocyanin, C-terminal domain | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase dimerisation domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Hemocyanin, N-terminal domain | 0 | Direct |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | Direct |
| L-alanine dehydrogenase-like | 0 | Direct |
| Nqo1 FMN-binding domain-like | 0 | Direct |
| Eukaryotic type heme oxygenase | 0 | Direct |
| 7-Fe ferredoxin | 0 | Direct |
| Glycerol-3-phosphate dehydrogenase | 0 | Direct |
| FAD-linked oxidases, N-terminal domain | 0 | Direct |
| NADH:FMN oxidoreductase-like | 0 | Direct |
| Catalase, C-terminal domain | 0 | Direct |
| Desulforedoxin | 0 | Direct |
| Penicillin synthase-like | 0 | Direct |
| Nqo5-like | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| C1-like domain | 0 | Direct |
| Dihydrodipicolinate reductase-like | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| Ubiquinol-cytochrome c reductase 8 kDa protein | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Thioltransferase | 0 | Direct |
| ArsC-like | 0 | Direct |
| 3-hydroxyanthranilic acid dioxygenase-like | 0 | Direct |
| PdxA-like | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | Direct |
| Periplasmic domain of cytochrome c oxidase subunit II | 0 | Direct |
| C-terminal domain of adrenodoxin reductase-like | 0 | Direct |
| Ring hydroxylating beta subunit | 0 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | Direct |
| Flavohemoglobin, C-terminal domain | 0 | Direct |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain | 0 | Direct |
| Cytochrome c oxidase subunit III-like | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| R1 subunit of ribonucleotide reductase, C-terminal domain | 0 | Direct |
| Methylamine dehydrogenase, L chain | 0 | Direct |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
| Bacterial tryptophan 2,3-dioxygenase | 0 | Direct |
| Glycine dehydrogenase subunits (GDC-P) | 0 | Direct |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | Direct |
| Ketopantoate reductase PanE | 0 | Direct |
| Superoxide reductase-like | 0 | Direct |
| MioX-like | 0 | Direct |
| Animal lipoxigenases | 0 | Direct |
| Aldo-keto reductases (NADP) | 0 | Direct |
| Nickel-iron hydrogenase, small subunit | 0 | Direct |
| Aminoacid dehydrogenases | 0 | Direct |
| Oxidoreductase molybdopterin-binding domain | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
| Homoserine dehydrogenase-like | 0 | Direct |
| Quinone reductase | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
| Nqo1 middle domain-like | 0 | Direct |
| PhyH-like | 0 | Direct |
| SelR domain | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, C-terminal domain | 0 | Direct |
| Ring hydroxylating alpha subunit ISP domain | 0 | Direct |
| Ribonucleotide reductase-like | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Siroheme synthase N-terminal domain-like | 0 | Direct |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | Direct |
| Dihydrofolate reductases | 0 | Direct |
| Nqo4-like | 0 | Direct |
| TyrA dimerization domain-like | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| Bacterial luciferase (alkanal monooxygenase) | 0 | Direct |
| Photosystem I subunits PsaA/PsaB | 0 | Direct |
| N-(1-D-carboxylethyl)-L-norvaline dehydrogenase | 0 | Direct |
| Reductases | 0 | Direct |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | Direct |
| ALDH-like | 0 | Direct |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| AhpD | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Homogentisate dioxygenase | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | Direct |
| Catechol oxidase | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Cytochrome b5 | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase, C-terminal domain | 0 | Direct |
| Duplicated SiR/NiR-like domains 1 and 3 | 0 | Direct |
| B12-dependent (class II) ribonucleotide reductase | 0 | Direct |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| LigB-like | 0 | Direct |
| PFOR PP module | 0 | Direct |
| Methylamine dehydrogenase, H-chain | 0 | Direct |
| Carbon monoxide dehydrogenase | 0 | Direct |
| PG130-like | 0 | Direct |
| Proline dehydrohenase domain of bifunctional PutA protein | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| RibD C-terminal domain-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| Mannitol 2-dehydrogenase | 0 | Direct |
| Ferredoxin domains from multidomain proteins | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Glutathione peroxidase-like | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Lipoxigenase N-terminal domain | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| ISP transmembrane anchor | 0 | Direct |
| Di-heme elbow motif | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| PFOR Pyr module | 0 | Direct |
| Urate oxidase (uricase) | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
| FAD-linked reductases, N-terminal domain | 0 | Direct |
| NQO2-like | 0 | Direct |
| HMD dimerization domain-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Ssud-like monoxygenases | 0 | Direct |
| NADH oxidase/flavin reductase | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) | 0 | Direct |
| Sulfiredoxin-like | 0 | Direct |
| GMC oxidoreductases | 0 | Direct |
| Iron-containing alcohol dehydrogenase | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Nqo1C-terminal domain-like | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| NADPH-dependent FMN reductase | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Hemocyanin middle domain | 0 | Direct |
| Cytochrome c oxidase subunit I-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Ring hydroxylating alpha subunit catalytic domain | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | Direct |
| Nitrogenase iron-molybdenum protein | 0 | Direct |
| Nq06-like | 0 | Direct |
| Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain II | 0 | Direct |
| Shikimate dehydrogenase-like | 0 | Direct |
| L-histidinol dehydrogenase HisD | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| Plant lipoxigenases | 0 | Direct |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | Direct |
| Peptide methionine sulfoxide reductase | 0 | Direct |
| Molybdenum-containing oxidoreductases-like dimerisation domain | 0 | Direct |
| Cytokinin dehydrogenase 1 | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| Dihydropyrimidine dehydrogenase, N-terminal domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | Direct |
| Nitrosocyanin | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| ProC C-terminal domain-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Nickel-iron hydrogenase, large subunit | 0 | Direct |
| Cysteine dioxygenase type I | 0 | Direct |
| N-terminal domain of adrenodoxin reductase-like | 0 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | Direct |
| Transhydrogenase domain III (dIII) | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Glucose 6-phosphate dehydrogenase-like | 0 | Direct |
| Phenylalanine metabolism regulatory domain | 0.000000000007432 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0.0000000000227 | Direct |
| Germin/Seed storage 7S protein | 0.000009736 | Direct |
| Acyl-carrier protein (ACP) | 0.000009863 | Direct |
| Haloperoxidase | 0.00005938 | Direct |
| Deoxycytidylate deaminase-like | 0.00018 | Direct |
| EGF-type module | 0.001093 | Inherited |
| Aspartokinase allosteric domain-like | 0.001417 | Inherited |
| Nitrous oxide reductase, N-terminal domain | 0.002878 | Inherited |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.006412 | Inherited |
| Ornithine cyclodeaminase-like | 0.006412 | Inherited |
| MaoC-like | 0.006796 | Inherited |
| Ngr ectodomain-like | 0.01216 | Inherited |
| FabD-like | 0.01463 | Inherited |
| PDZ domain | 0.02756 | Inherited |
| FHA domain | 0.09997 | Inherited |
| Shikimate kinase (AroK) | 0.1405 | Inherited |
| Dihydropteroate synthetase | 0.1768 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.2061 | Inherited |
| HMA, heavy metal-associated domain | 0.2893 | Inherited |
| Transketolase C-terminal domain-like | 0.4182 | Inherited |
| Complement control module/SCR domain | 0.4674 | Inherited |
| PHD domain | 0.4996 | Inherited |
| Calmodulin-like | 0.6008 | Inherited |
| Phosphotransacetylase | 0.6469 | Inherited |
| TK-like Pyr module | 0.8924 | Inherited |
| Dehydroquinate synthase, DHQS | 0.9607 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 1 | Inherited |
| Enolpyruvate transferase, EPT | 1 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 1 | Inherited |
| Thiolase-related | 1 | Inherited |
| Aminomethyltransferase beta-barrel domain | 1 | Inherited |
| TK-like PP module | 1 | Inherited |
| Tandem AAA-ATPase domain | 1 | Inherited |
| PyrH-like | 1 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 1 | Inherited |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| I set domains | 1 | Inherited |
| GTP cyclohydrolase I | 1 | Inherited |
| Class II glutamine amidotransferases | 1 | Inherited |
| Post formyltransferase domain | 1 | Inherited |
| Aminomethyltransferase folate-binding domain | 1 | Inherited |
| Class I aldolase | 1 | Inherited |
| Nitrogenase iron protein-like | 1 | Inherited |
| HisI-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| Heme oxygenase-like | 0 | DIRECT |
| Dihydropteroate synthetase-like | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Frataxin/Nqo15-like | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Peptide methionine sulfoxide reductase | 0 | DIRECT |
| Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
| Bacterial luciferase-like | 0 | DIRECT |
| Fe-only hydrogenase | 0 | DIRECT |
| Nqo1C-terminal domain-like | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
| HydB/Nqo4-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| ParB/Sulfiredoxin | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Respiratory nitrate reductase 1 gamma chain | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| Nqo5-like | 0 | DIRECT |
| Ribbon-helix-helix | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
| Thioredoxin-like | 0 | DIRECT |
| Cytochrome c oxidase subunit I-like | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
| Prismane protein-like | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
| Nqo1 FMN-binding domain-like | 0 | DIRECT |
| LigB-like | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Globin-like | 0 | DIRECT |
| Cytochrome c oxidase subunit III-like | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| ISP transmembrane anchor | 0 | DIRECT |
| alpha-helical ferredoxin | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Dihydrofolate reductase-like | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
| FMN-dependent nitroreductase-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| PFL-like glycyl radical enzymes | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| Nqo1 middle domain-like | 0 | DIRECT |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| N-terminal domain of bifunctional PutA protein | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Aromatic compound dioxygenase | 0 | DIRECT |
| Clavaminate synthase-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
| YebC-like | 0 | DIRECT |
| Superoxide reductase-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Multiheme cytochromes | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0 | DIRECT |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
| Methylamine dehydrogenase, L chain | 0 | DIRECT |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | DIRECT |
| Hemocyanin, N-terminal domain | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| "Helical backbone" metal receptor | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Nucleotide-binding domain | 0 | DIRECT |
| HydA/Nqo6-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| PHM/PNGase F | 0.00000000000003323 | DIRECT |
| Non-globular alpha+beta subunits of globular proteins | 0.000000000003717 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.00000000004086 | DIRECT |
| Serine metabolism enzymes domain | 0.000000003723 | DIRECT |
| Rubredoxin-like | 0.0000004278 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.000000853 | DIRECT |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.000009617 | DIRECT |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.00006834 | DIRECT |
| SRCR-like | 0.00008042 | DIRECT |
| NTF2-like | 0.0001706 | DIRECT |
| EGF/Laminin | 0.000188 | DIRECT |
| HSP20-like chaperones | 0.001017 | INHERITED FROM: Acting on NADH or NADPH || Cytochrome-b5 reductase || With a heme protein as acceptor |
| NHL repeat | 0.00108 | INHERITED FROM: With reduced ascorbate as one donor, and incorpora || Acting on paired donors, with incorporation or red || Peptidylglycine monooxygenase |
| ACT-like | 0.004803 | INHERITED FROM: Phosphoglycerate dehydrogenase || Prephenate dehydrogenase || Acting on paired donors, with incorporation or red || Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || With reduced pteridine as one donor, and incorpora || With NAD(+) or NADP(+) as acceptor |
| FnI-like domain | 0.006389 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| SCP-like | 0.008757 | INHERITED FROM: 1.1.1.n12 || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| Nitrous oxide reductase, N-terminal domain | 0.02109 | INHERITED FROM: Acting on other nitrogenous compounds as donors || Nitrous-oxide reductase || With a cytochrome as acceptor |
| ARM repeat | 0.05133 | INHERITED FROM: Acting on paired donors, with incorporation or red || Deoxyhypusine monooxygenase || Miscellaneous (requires further characterization) |
| FYVE/PHD zinc finger | 0.05978 | INHERITED FROM: Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || [Histone H3]-lysine-36 demethylase |
| Lipocalins | 0.0901 | INHERITED FROM: With other acceptors || Violaxanthin de-epoxidase || Acting on diphenols and related substances as dono |
| Electron transport accessory proteins | 0.1116 | INHERITED FROM: Dihydrofolate reductase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor |
| SMAD/FHA domain | 0.1163 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Zeaxanthin epoxidase |
| TPR-like | 0.1278 | INHERITED FROM: Procollagen-proline 3-dioxygenase || Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || Procollagen-proline dioxygenase || Peptide-aspartate beta-dioxygenase |
| ACP-like | 0.1458 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || L-aminoadipate-semialdehyde dehydrogenase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the aldehyde or oxo group of donors |
| Dimeric alpha+beta barrel | 0.2124 | INHERITED FROM: Acting on paired donors, with incorporation or red || Miscellaneous (requires further characterization) || Heme oxygenase |
| Chorismate mutase II | 0.2701 | INHERITED FROM: Prephenate dehydrogenase || Acting on the CH-CH group of donors || With NAD(+) or NADP(+) as acceptor |
| HMA, heavy metal-associated domain | 0.2861 | INHERITED FROM: Mercury(II) reductase || Oxidizing metal ions || With NAD(+) or NADP(+) as acceptor |
| TK C-terminal domain-like | 0.324 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || With an iron-sulfur protein as acceptor || Acting on the aldehyde or oxo group of donors |
| RNI-like | 0.4225 | INHERITED FROM: Acting on paired donors, with incorporation or red || With 2-oxoglutarate as one donor, and incorporatio || [Histone H3]-lysine-36 demethylase |
| Complement control module/SCR domain | 0.4653 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Iodide peroxidase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7282 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| Calcium-dependent phosphotriesterase | 0.8769 | INHERITED FROM: With reduced ascorbate as one donor, and incorpora || Acting on paired donors, with incorporation or red || Peptidylglycine monooxygenase |
| Ubiquitin-like | 1 | INHERITED FROM: Trans-2-enoyl-CoA reductase (NADPH) || With NAD(+) or NADP(+) as acceptor |
| 4'-phosphopantetheinyl transferase | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Enolase C-terminal domain-like | 1 | INHERITED FROM: Acting on CH or CH(2) groups || With an iron-sulfur protein as acceptor || (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth |
| Folate-binding domain | 1 | INHERITED FROM: With oxygen as acceptor || Sarcosine oxidase || With a flavin as acceptor || Acting on the CH-NH group of donors |
| Hedgehog/intein (Hint) domain | 1 | INHERITED FROM: With a disulfide as acceptor || Ribonucleoside-diphosphate reductase || Acting on CH or CH(2) groups |
| EF-hand | 1 | INHERITED FROM: Acting on NADH or NADPH || With a oxygen as acceptor || Glycerol-3-phosphate dehydrogenase || With a quinone or similar compound as acceptor || Plant seed peroxygenase || With H(2)O(2) as acceptor, one oxygen atom of whic |
| Cysteine-rich domain | 1 | INHERITED FROM: Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor || Protein-disulfide reductase |
| Aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| all-alpha NTP pyrophosphatases | 1 | INHERITED FROM: Histidinol dehydrogenase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: With 2-oxoglutarate as one donor, and incorporatio || Procollagen-lysine 5-dioxygenase |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| Immunoglobulin | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With a flavin as acceptor || Acting on the CH-NH group of donors |
| L domain-like | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: With incorporation of one atom of oxygen || Photinus-luciferin 4-monooxygenase (ATP-hydrolyzin || L-aminoadipate-semialdehyde dehydrogenase |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || With an iron-sulfur protein as acceptor || Glutamate synthase (NADH) || Acting on the CH-NH(2) group of donors || Glutamate synthase (NADPH) |
| HD-domain/PDEase-like | 1 | INHERITED FROM: Miscellaneous (requires further characterization) || Acting on single donors with incorporation of mole |
| DHS-like NAD/FAD-binding domain | 1 | INHERITED FROM: NAD(P)(+) transhydrogenase (AB-specific) || With NAD(+) or NADP(+) as acceptor |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Radical SAM enzymes | 1 | INHERITED FROM: With other acceptors || Coproporphyrinogen dehydrogenase || [Formate-C-acetyltransferase]-activating enzyme |
| E set domains | 1 | INHERITED FROM: Sulfite oxidase || Nitrate reductase (NADH) || With oxygen as acceptor || Acting on other nitrogenous compounds as donors || Nitrate reductase (NADPH) || Monophenol monooxygenase || With NAD(+) or NADP(+) as acceptor || With another compound as one donor, and incorporat |
| Cytidine deaminase-like | 1 | INHERITED FROM: 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| EPT/RTPC-like | 1 | INHERITED FROM: Shikimate dehydrogenase |
| PLP-dependent transferases | 1 | INHERITED FROM: Acting on the CH-NH(2) group of donors || With a disulfide as acceptor |
| Metallo-hydrolase/oxidoreductase | 1 | INHERITED FROM: CMP-N-acetylneuraminate monooxygenase || With another compound as one donor, and incorporat |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Chloride peroxidase || 3-oxoacyl-[acyl-carrier-protein] reductase |
| PDZ domain-like | 1 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Nitric-oxide synthase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: With dinitrogen as acceptor || Shikimate dehydrogenase || Thymine dioxygenase || Acting on iron-sulfur proteins as donors |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || 1.1.1.n12 || Carnitine 3-dehydrogenase |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | INHERITED FROM: Dihydrofolate reductase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor |
| Formyltransferase | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
| FabD/lysophospholipase-like | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| ClpP/crotonase | 1 | INHERITED FROM: Long-chain-3-hydroxyacyl-CoA dehydrogenase || 3-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| GST C-terminal domain-like | 1 | INHERITED FROM: Acting on a sulfur group of donors || Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With disulfide as acceptor || With a quinone or similar compound as acceptor || Methylarsonate reductase |
| Thiolase-like | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || 3-oxoacyl-[acyl-carrier-protein] reductase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: L-aminoadipate-semialdehyde dehydrogenase |
| Adenine nucleotide alpha hydrolases-like | 1 | INHERITED FROM: Acting on a sulfur group of donors || Phosphoadenylyl-sulfate reductase (thioredoxin) || With a disulfide as acceptor |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Catalase |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Bromide peroxidase |
| FMT C-terminal domain-like | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
| Carbamate kinase-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| Heme oxygenase-like | 0 | Direct |
| Dihydropteroate synthetase-like | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Frataxin/Nqo15-like | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| Peptide methionine sulfoxide reductase | 0 | Direct |
| Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
| Bacterial luciferase-like | 0 | Direct |
| Fe-only hydrogenase | 0 | Direct |
| Nqo1C-terminal domain-like | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| FAD-linked oxidoreductase | 0 | Direct |
| NAD(P)-binding Rossmann-fold domains | 0 | Direct |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
| HydB/Nqo4-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Mss4-like | 0 | Direct |
| ADC-like | 0 | Direct |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| GroES-like | 0 | Direct |
| ParB/Sulfiredoxin | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Respiratory nitrate reductase 1 gamma chain | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| Nqo5-like | 0 | Direct |
| Ribbon-helix-helix | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
| Thioredoxin-like | 0 | Direct |
| Cytochrome c oxidase subunit I-like | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
| Prismane protein-like | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| AhpD-like | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
| Nqo1 FMN-binding domain-like | 0 | Direct |
| LigB-like | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Globin-like | 0 | Direct |
| Cytochrome c oxidase subunit III-like | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| ISP transmembrane anchor | 0 | Direct |
| alpha-helical ferredoxin | 0 | Direct |
| ISP domain | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Dihydrofolate reductase-like | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
| FMN-dependent nitroreductase-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| PFL-like glycyl radical enzymes | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| Nqo1 middle domain-like | 0 | Direct |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
| Methanol dehydrogenase subunit | 0 | Direct |
| N-terminal domain of bifunctional PutA protein | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Aromatic compound dioxygenase | 0 | Direct |
| Clavaminate synthase-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Photosystem I subunits PsaA/PsaB | 0 | Direct |
| YebC-like | 0 | Direct |
| Superoxide reductase-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Multiheme cytochromes | 0 | Direct |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0 | Direct |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
| Methylamine dehydrogenase, L chain | 0 | Direct |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | Direct |
| Hemocyanin, N-terminal domain | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Oxidoreductase molybdopterin-binding domain | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| "Helical backbone" metal receptor | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Nucleotide-binding domain | 0 | Direct |
| HydA/Nqo6-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Flavoproteins | 0 | Direct |
| PHM/PNGase F | 0.00000000000003323 | Direct |
| Non-globular alpha+beta subunits of globular proteins | 0.000000000003717 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.00000000004086 | Direct |
| Serine metabolism enzymes domain | 0.000000003723 | Direct |
| Rubredoxin-like | 0.0000004278 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0.000000853 | Direct |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.000009617 | Direct |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.00006834 | Direct |
| SRCR-like | 0.00008042 | Direct |
| NTF2-like | 0.0001706 | Direct |
| EGF/Laminin | 0.000188 | Direct |
| HSP20-like chaperones | 0.001017 | Inherited |
| NHL repeat | 0.00108 | Inherited |
| ACT-like | 0.004803 | Inherited |
| FnI-like domain | 0.006389 | Inherited |
| SCP-like | 0.008757 | Inherited |
| Nitrous oxide reductase, N-terminal domain | 0.02109 | Inherited |
| ARM repeat | 0.05133 | Inherited |
| FYVE/PHD zinc finger | 0.05978 | Inherited |
| Lipocalins | 0.0901 | Inherited |
| Electron transport accessory proteins | 0.1116 | Inherited |
| SMAD/FHA domain | 0.1163 | Inherited |
| TPR-like | 0.1278 | Inherited |
| ACP-like | 0.1458 | Inherited |
| Dimeric alpha+beta barrel | 0.2124 | Inherited |
| Chorismate mutase II | 0.2701 | Inherited |
| HMA, heavy metal-associated domain | 0.2861 | Inherited |
| TK C-terminal domain-like | 0.324 | Inherited |
| RNI-like | 0.4225 | Inherited |
| Complement control module/SCR domain | 0.4653 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7282 | Inherited |
| Calcium-dependent phosphotriesterase | 0.8769 | Inherited |
| Ubiquitin-like | 1 | Inherited |
| 4'-phosphopantetheinyl transferase | 1 | Inherited |
| Enolase C-terminal domain-like | 1 | Inherited |
| Folate-binding domain | 1 | Inherited |
| Hedgehog/intein (Hint) domain | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Cysteine-rich domain | 1 | Inherited |
| Aldolase | 1 | Inherited |
| all-alpha NTP pyrophosphatases | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Aminomethyltransferase beta-barrel domain | 1 | Inherited |
| L domain-like | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| DHS-like NAD/FAD-binding domain | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| HisI-like | 1 | Inherited |
| Radical SAM enzymes | 1 | Inherited |
| E set domains | 1 | Inherited |
| Cytidine deaminase-like | 1 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Metallo-hydrolase/oxidoreductase | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | Inherited |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| FabD/lysophospholipase-like | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Adenine nucleotide alpha hydrolases-like | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | Inherited |
| FMT C-terminal domain-like | 1 | Inherited |
| Carbamate kinase-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52402,52833
52402 - Adenine nucleotide alpha hydrolases-like
52833 - Thioredoxin-like | 0 | DIRECT |
69336,50692
69336 - Alpha subunit of glutamate synthase, C-terminal domain
50692 - ADC-like | 0 | DIRECT |
46548,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain | 0 | DIRECT |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | DIRECT |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
53706,50692
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | DIRECT |
54292,63380
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
51182,51182
51182 - RmlC-like cupins
51182 - RmlC-like cupins | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
142984,140490
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | DIRECT |
56014,55124
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
47336,53720
47336 - ACP-like
53720 - ALDH-like | 0 | DIRECT |
51905,51905
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
55856,56524
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
56014,50022
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | DIRECT |
55447,54665
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
69742,51735
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
48179,55021
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | DIRECT |
53597,55831
53597 - Dihydrofolate reductase-like
55831 - Thymidylate synthase/dCMP hydroxymethylase | 0 | DIRECT |
81935,51730
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | DIRECT |
51905,54862
51905 - FAD/NAD(P)-binding domain
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
46458,63380
46458 - Globin-like
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
143243,56762
143243 - Nqo5-like
56762 - HydB/Nqo4-like | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
52518,52218
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52218 - Flavoproteins | 0 | DIRECT |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
52218,63380
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
56524,81296
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | DIRECT |
81502,50022
81502 - ISP transmembrane anchor
50022 - ISP domain | 0 | DIRECT |
48264,52218
48264 - Cytochrome P450
52218 - Flavoproteins | 0 | DIRECT |
52833,57889
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
53383,53383
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 0 | DIRECT |
54862,53706
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
56176,55447
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
51395,51971
51395 - FMN-linked oxidoreductases
51971 - Nucleotide-binding domain | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
50022,55961
50022 - ISP domain
55961 - Bet v1-like | 0 | DIRECT |
51395,54862
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
48695,51905
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
46609,54719
46609 - Fe,Mn superoxide dismutase (SOD), N-terminal domain
54719 - Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
53633,53720
53633 - Carbamate kinase-like
53720 - ALDH-like | 0 | DIRECT |
56512,52218
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins | 0 | DIRECT |
51905,52833
51905 - FAD/NAD(P)-binding domain
52833 - Thioredoxin-like | 0 | DIRECT |
51735,53659
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
54292,46548
54292 - 2Fe-2S ferredoxin-like
46548 - alpha-helical ferredoxin | 0 | DIRECT |
51971,51905
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
48050,48056
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain | 0 | DIRECT |
56176,56194
56176 - FAD-binding/transporter-associated domain-like
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
51971,51395
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
53927,53597
53927 - Cytidine deaminase-like
53597 - Dihydrofolate reductase-like | 0 | DIRECT |
56634,52317
56634 - Heme-dependent catalase-like
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
50486,47336
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | DIRECT |
81464,49503
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins | 0 | DIRECT |
51971,51971
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
51366,56014
51366 - Ribulose-phoshate binding barrel
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
55856,49764
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
50974,49503
50974 - Nitrous oxide reductase, N-terminal domain
49503 - Cupredoxins | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
46626,46626
46626 - Cytochrome c
46626 - Cytochrome c | 0 | DIRECT |
56228,48310
56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain
48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
81442,81464
81442 - Cytochrome c oxidase subunit I-like
81464 - Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
56568,81502
56568 - Non-globular alpha+beta subunits of globular proteins
81502 - ISP transmembrane anchor | 0 | DIRECT |
55008,51905
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
51735,69075
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
56425,46977
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
48168,51998
48168 - R1 subunit of ribonucleotide reductase, N-terminal domain
51998 - PFL-like glycyl radical enzymes | 0 | DIRECT |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | DIRECT |
46626,51004
46626 - Cytochrome c
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0 | DIRECT |
51730,53720
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
51905,51971
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
47598,81935
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
142019,142984
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like | 0 | DIRECT |
54292,54862
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
51735,55021
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | DIRECT |
52518,54862
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
48056,81296
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | DIRECT |
48113,48113
48113 - Heme-dependent peroxidases
48113 - Heme-dependent peroxidases | 0 | DIRECT |
48179,54637
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
54862,56014
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
53720,56796
53720 - ALDH-like
56796 - Dehydroquinate synthase-like | 0 | DIRECT |
75625,51998
75625 - YebC-like
51998 - PFL-like glycyl radical enzymes | 0 | DIRECT |
51412,56014
51412 - Inosine monophosphate dehydrogenase (IMPDH)
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
49503,46626
49503 - Cupredoxins
46626 - Cytochrome c | 0 | DIRECT |
54862,53920
54862 - 4Fe-4S ferredoxins
53920 - Fe-only hydrogenase | 0 | DIRECT |
54416,49998
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | DIRECT |
48452,51197
48452 - TPR-like
51197 - Clavaminate synthase-like | 0 | DIRECT |
51717,56014
51717 - Dihydropteroate synthetase-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
49764,63380
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
55068,51316
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | DIRECT |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
55347,55021
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | DIRECT |
57196,48113
57196 - EGF/Laminin
48113 - Heme-dependent peroxidases | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
48179,52413
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
51604,56014
51604 - Enolase C-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
51735,143548
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | DIRECT |
52833,51905
52833 - Thioredoxin-like
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
50998,46626
50998 - Quinoprotein alcohol dehydrogenase-like
46626 - Cytochrome c | 0 | DIRECT |
51412,51412
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
55124,54862
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
51395,56014
51395 - FMN-linked oxidoreductases
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
52833,55068
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase | 0 | DIRECT |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
52922,52518
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
56770,143243
56770 - HydA/Nqo6-like
143243 - Nqo5-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
50022,56281
50022 - ISP domain
56281 - Metallo-hydrolase/oxidoreductase | 0 | DIRECT |
55035,56542
55035 - NAD-binding domain of HMG-CoA reductase
56542 - Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
52922,53323
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
55021,51735
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
55856,63380
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
54631,51412
54631 - CBS-domain pair
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
54416,54416
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | DIRECT |
56821,46548
56821 - Prismane protein-like
46548 - alpha-helical ferredoxin | 0 | DIRECT |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
55347,69055
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
51182,52833
51182 - RmlC-like cupins
52833 - Thioredoxin-like | 0 | DIRECT |
55124,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
81296,55856
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
57802,49367
57802 - Rubredoxin-like
49367 - Superoxide reductase-like | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 8.731e-16 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.00000000000003323 | DIRECT |
143548,55021
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0.0000002433 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00005898 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0001573 | DIRECT |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.001163 | INHERITED FROM: Biphenyl-2,3-diol 1,2-dioxygenase || With incorporation of two atoms of oxygen || Acting on single donors with incorporation of mole |
53633,55021
53633 - Carbamate kinase-like
55021 - ACT-like | 0.001861 | INHERITED FROM: Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.004617 | INHERITED FROM: 1.1.1.n12 || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.01437 | INHERITED FROM: L-aminoadipate-semialdehyde dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the aldehyde or oxo group of donors |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0.03897 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0886 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.4088 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) || With an iron-sulfur protein as acceptor || Acting on the aldehyde or oxo group of donors |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4233 | INHERITED FROM: Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor || Protein-disulfide reductase |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.569 | INHERITED FROM: With a disulfide as acceptor || Oxoglutarate dehydrogenase (succinyl-transferring) || Acting on the aldehyde or oxo group of donors |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7282 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0.8286 | INHERITED FROM: Histidinol dehydrogenase |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: With 2-oxoglutarate as one donor, and incorporatio || Thymine dioxygenase |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 1 | INHERITED FROM: Acting on CH or CH(2) groups || With NAD(+) or NADP(+) as acceptor || 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | INHERITED FROM: Acting on a sulfur group of donors || Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With disulfide as acceptor || With a quinone or similar compound as acceptor || Methylarsonate reductase |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With a flavin as acceptor || Acting on the CH-NH group of donors |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 1 | INHERITED FROM: Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic || With NAD(+) or NADP(+) as acceptor || Formyltetrahydrofolate dehydrogenase |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52402,52833
52402 - Adenine nucleotide alpha hydrolases-like
52833 - Thioredoxin-like | 0 | Direct |
69336,50692
69336 - Alpha subunit of glutamate synthase, C-terminal domain
50692 - ADC-like | 0 | Direct |
46548,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain | 0 | Direct |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | Direct |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
53706,50692
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | Direct |
54292,63380
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like | 0 | Direct |
51182,51182
51182 - RmlC-like cupins
51182 - RmlC-like cupins | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
142984,140490
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | Direct |
56014,55124
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
47336,53720
47336 - ACP-like
53720 - ALDH-like | 0 | Direct |
51905,51905
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
55856,56524
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain | 0 | Direct |
56014,50022
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | Direct |
55447,54665
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
69742,51735
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
48179,55021
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | Direct |
53597,55831
53597 - Dihydrofolate reductase-like
55831 - Thymidylate synthase/dCMP hydroxymethylase | 0 | Direct |
81935,51730
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | Direct |
51905,54862
51905 - FAD/NAD(P)-binding domain
54862 - 4Fe-4S ferredoxins | 0 | Direct |
46458,63380
46458 - Globin-like
63380 - Riboflavin synthase domain-like | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
143243,56762
143243 - Nqo5-like
56762 - HydB/Nqo4-like | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
52518,52218
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52218 - Flavoproteins | 0 | Direct |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
52218,63380
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | Direct |
56524,81296
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | Direct |
81502,50022
81502 - ISP transmembrane anchor
50022 - ISP domain | 0 | Direct |
48264,52218
48264 - Cytochrome P450
52218 - Flavoproteins | 0 | Direct |
52833,57889
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | Direct |
53383,53383
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 0 | Direct |
54862,53706
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
56176,55447
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
51395,51971
51395 - FMN-linked oxidoreductases
51971 - Nucleotide-binding domain | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
50022,55961
50022 - ISP domain
55961 - Bet v1-like | 0 | Direct |
51395,54862
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
48695,51905
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
46609,54719
46609 - Fe,Mn superoxide dismutase (SOD), N-terminal domain
54719 - Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
53633,53720
53633 - Carbamate kinase-like
53720 - ALDH-like | 0 | Direct |
56512,52218
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins | 0 | Direct |
51905,52833
51905 - FAD/NAD(P)-binding domain
52833 - Thioredoxin-like | 0 | Direct |
51735,53659
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
54292,46548
54292 - 2Fe-2S ferredoxin-like
46548 - alpha-helical ferredoxin | 0 | Direct |
51971,51905
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
48050,48056
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain | 0 | Direct |
56176,56194
56176 - FAD-binding/transporter-associated domain-like
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
51971,51395
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
53927,53597
53927 - Cytidine deaminase-like
53597 - Dihydrofolate reductase-like | 0 | Direct |
56634,52317
56634 - Heme-dependent catalase-like
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
50486,47336
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | Direct |
81464,49503
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins | 0 | Direct |
51971,51971
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
51366,56014
51366 - Ribulose-phoshate binding barrel
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
55856,49764
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
50974,49503
50974 - Nitrous oxide reductase, N-terminal domain
49503 - Cupredoxins | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
46626,46626
46626 - Cytochrome c
46626 - Cytochrome c | 0 | Direct |
56228,48310
56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain
48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
81442,81464
81442 - Cytochrome c oxidase subunit I-like
81464 - Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
56568,81502
56568 - Non-globular alpha+beta subunits of globular proteins
81502 - ISP transmembrane anchor | 0 | Direct |
55008,51905
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
51735,69075
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
56425,46977
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
48168,51998
48168 - R1 subunit of ribonucleotide reductase, N-terminal domain
51998 - PFL-like glycyl radical enzymes | 0 | Direct |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | Direct |
46626,51004
46626 - Cytochrome c
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0 | Direct |
51730,53720
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | Direct |
51905,51971
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
47598,81935
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
142019,142984
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like | 0 | Direct |
54292,54862
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins | 0 | Direct |
51735,55021
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | Direct |
52518,54862
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | Direct |
48056,81296
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | Direct |
48113,48113
48113 - Heme-dependent peroxidases
48113 - Heme-dependent peroxidases | 0 | Direct |
48179,54637
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
54862,56014
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
53720,56796
53720 - ALDH-like
56796 - Dehydroquinate synthase-like | 0 | Direct |
75625,51998
75625 - YebC-like
51998 - PFL-like glycyl radical enzymes | 0 | Direct |
51412,56014
51412 - Inosine monophosphate dehydrogenase (IMPDH)
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
49503,46626
49503 - Cupredoxins
46626 - Cytochrome c | 0 | Direct |
54862,53920
54862 - 4Fe-4S ferredoxins
53920 - Fe-only hydrogenase | 0 | Direct |
54416,49998
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | Direct |
48452,51197
48452 - TPR-like
51197 - Clavaminate synthase-like | 0 | Direct |
51717,56014
51717 - Dihydropteroate synthetase-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
49764,63380
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | Direct |
55068,51316
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | Direct |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
55347,55021
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | Direct |
57196,48113
57196 - EGF/Laminin
48113 - Heme-dependent peroxidases | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
48179,52413
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
51604,56014
51604 - Enolase C-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
51735,143548
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | Direct |
52833,51905
52833 - Thioredoxin-like
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
50998,46626
50998 - Quinoprotein alcohol dehydrogenase-like
46626 - Cytochrome c | 0 | Direct |
51412,51412
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
55124,54862
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins | 0 | Direct |
51395,56014
51395 - FMN-linked oxidoreductases
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
52833,55068
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase | 0 | Direct |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
52922,52518
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
56770,143243
56770 - HydA/Nqo6-like
143243 - Nqo5-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
50022,56281
50022 - ISP domain
56281 - Metallo-hydrolase/oxidoreductase | 0 | Direct |
55035,56542
55035 - NAD-binding domain of HMG-CoA reductase
56542 - Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
52922,53323
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
55021,51735
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
55856,63380
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
54631,51412
54631 - CBS-domain pair
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
54416,54416
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | Direct |
56821,46548
56821 - Prismane protein-like
46548 - alpha-helical ferredoxin | 0 | Direct |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
55347,69055
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | Direct |
51182,52833
51182 - RmlC-like cupins
52833 - Thioredoxin-like | 0 | Direct |
55124,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
81296,55856
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
57802,49367
57802 - Rubredoxin-like
49367 - Superoxide reductase-like | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 8.731e-16 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.00000000000003323 | Direct |
143548,55021
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0.0000002433 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00005898 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0001573 | Direct |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.001163 | Inherited |
53633,55021
53633 - Carbamate kinase-like
55021 - ACT-like | 0.001861 | Inherited |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.004617 | Inherited |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.01437 | Inherited |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0.03897 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0886 | Inherited |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.4088 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4233 | Inherited |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.569 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7282 | Inherited |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0.8286 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 1 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 1 | Inherited |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 1 | Inherited |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52833,52833,57889
52833 - Thioredoxin-like
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
51971,51971,51395
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
69742,51735,69075
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81935,51730,53720
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | DIRECT |
47741,56176,55447
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
51735,48179,55021
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | DIRECT |
51735,55347,69055
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
55124,56014,55124
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
56512,52218,63380
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
56014,55124,56014
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
52218,63380,52343
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
52283,51735,55021
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | DIRECT |
81296,55856,63380
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
46548,51971,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
56770,143243,56762
56770 - HydA/Nqo6-like
143243 - Nqo5-like
56762 - HydB/Nqo4-like | 0 | DIRECT |
52283,51735,143548
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | DIRECT |
51971,51905,55424
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0 | DIRECT |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
55856,49764,63380
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
46458,63380,52343
46458 - Globin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
50486,47336,53720
50486 - FMT C-terminal domain-like
47336 - ACP-like
53720 - ALDH-like | 0 | DIRECT |
54292,54862,53706
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
55124,56014,50022
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | DIRECT |
51905,56425,46977
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
81464,49503,46626
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins
46626 - Cytochrome c | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
55008,51905,55424
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55124,54862,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
48050,48056,81296
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | DIRECT |
142019,142984,140490
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | DIRECT |
48695,51905,56425
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
56524,81296,55856
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
55856,56524,81296
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | DIRECT |
52922,52518,54862
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
56176,55447,54665
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54416,54416,49998
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | DIRECT |
52518,52922,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,55347,55021
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | DIRECT |
56568,81502,50022
56568 - Non-globular alpha+beta subunits of globular proteins
81502 - ISP transmembrane anchor
50022 - ISP domain | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
48264,52218,63380
48264 - Cytochrome P450
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
54292,63380,52343
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
47598,81935,51730
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | DIRECT |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
51971,51395,54862
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
54862,53706,50692
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | DIRECT |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
53328,50486,47336
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | DIRECT |
53223,51735,53659
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
55021,55021,51735
55021 - ACT-like
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51971,51905,51971
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
55856,63380,52343
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
51905,51905,55424
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
55447,54665,56003
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
51735,48179,54637
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,52413
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
52833,55068,51316
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | DIRECT |
49764,63380,52343
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
51735,143548,55021
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0 | DIRECT |
55021,51735,55347
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000009788 | DIRECT |
53633,55021,55021
53633 - Carbamate kinase-like
55021 - ACT-like
55021 - ACT-like | 0.001861 | INHERITED FROM: Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.003918 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.03084 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.05904 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.8442 | INHERITED FROM: Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor || Protein-disulfide reductase |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase |
52518,52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 1 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52833,52833,57889
52833 - Thioredoxin-like
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | Direct |
51971,51971,51395
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
69742,51735,69075
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81935,51730,53720
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | Direct |
47741,56176,55447
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
51735,48179,55021
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | Direct |
51735,55347,69055
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
55124,56014,55124
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
56512,52218,63380
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | Direct |
56014,55124,56014
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
52218,63380,52343
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
52283,51735,55021
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | Direct |
81296,55856,63380
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | Direct |
46548,51971,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
56770,143243,56762
56770 - HydA/Nqo6-like
143243 - Nqo5-like
56762 - HydB/Nqo4-like | 0 | Direct |
52283,51735,143548
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | Direct |
51971,51905,55424
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0 | Direct |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
55856,49764,63380
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | Direct |
46458,63380,52343
46458 - Globin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
50486,47336,53720
50486 - FMT C-terminal domain-like
47336 - ACP-like
53720 - ALDH-like | 0 | Direct |
54292,54862,53706
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
55124,56014,50022
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | Direct |
51905,56425,46977
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
81464,49503,46626
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins
46626 - Cytochrome c | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
55008,51905,55424
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55124,54862,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
48050,48056,81296
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | Direct |
142019,142984,140490
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | Direct |
48695,51905,56425
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
56524,81296,55856
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
55856,56524,81296
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | Direct |
52922,52518,54862
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | Direct |
56176,55447,54665
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54416,54416,49998
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | Direct |
52518,52922,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
51735,55347,55021
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | Direct |
56568,81502,50022
56568 - Non-globular alpha+beta subunits of globular proteins
81502 - ISP transmembrane anchor
50022 - ISP domain | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
48264,52218,63380
48264 - Cytochrome P450
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | Direct |
54292,63380,52343
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
47598,81935,51730
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | Direct |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
51971,51395,54862
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | Direct |
54862,53706,50692
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | Direct |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
53328,50486,47336
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | Direct |
53223,51735,53659
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
55021,55021,51735
55021 - ACT-like
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51971,51905,51971
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | Direct |
55856,63380,52343
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
51905,51905,55424
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
55447,54665,56003
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
51735,48179,54637
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,52413
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
52833,55068,51316
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | Direct |
49764,63380,52343
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
51735,143548,55021
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0 | Direct |
55021,51735,55347
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000009788 | Direct |
53633,55021,55021
53633 - Carbamate kinase-like
55021 - ACT-like
55021 - ACT-like | 0.001861 | Inherited |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.003918 | Inherited |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.03084 | Inherited |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.05904 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.8442 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
52518,52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
