Methyltransferases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + 3:	root [root] <6>
+ + 2:	Transferases [2] <10>	(363|551)	(398|460|240)
+ 1:	Transferring one-carbon groups [2.1] <4>	(69|105)	(78|71|28)
0:	Methyltransferases [2.1.1] <249>	(50|84)	(59|54|12)
- 1:	(FADH(2)-oxidizing) [2.1.1.74]	(1|0)	(1|0|0)
- 1:	(Iso)eugenol O-methyltransferase [2.1.1.146]	(0|0)	(1|1|0)
- 1:	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-met [2.1.1.115]	(0|0)	(0|0|0)
- 1:	(RS)-norcoclaurine 6-O-methyltransferase [2.1.1.128]	(0|0)	(0|0|0)
- 1:	(S)-coclaurine-N-methyltransferase [2.1.1.140]	(0|0)	(0|0|0)
- 1:	(S)-scoulerine 9-O-methyltransferase [2.1.1.117]	(0|0)	(0|0|0)
- 1:	(S)-tetrahydroprotoberberine N-methyltransferase [2.1.1.122]	(0|0)	(0|0|0)
- 1:	10-hydroxydihydrosanguinarine 10-O-methyltransfera [2.1.1.119]	(0|0)	(0|0|0)
- 1:	12-hydroxydihydrochelirubine 12-O-methyltransferas [2.1.1.120]	(0|0)	(0|0|0)
- 1:	16S rRNA (adenine(1408)-N(1))-methyltransferase [2.1.1.180]	(0|0)	(0|0|0)
- 1:	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-d [2.1.1.182]	(1|1)	(1|0|0)
- 1:	16S rRNA (cytidine(1402)-2'-O)-methyltransferase [2.1.1.198]	(1|1)	(1|0|0)
- 1:	16S rRNA (cytidine(1409)-2'-O)-methyltransferase [2.1.1.227]	(0|0)	(0|0|0)
- 1:	16S rRNA (cytosine(1402)-N(4))-methyltransferase [2.1.1.199]	(2|2)	(2|1|0)
- 1:	16S rRNA (cytosine(1407)-C(5))-methyltransferase [2.1.1.178]	(1|1)	(1|0|0)
- 1:	16S rRNA (cytosine(967)-C(5))-methyltransferase [2.1.1.176]	(2|2)	(2|1|0)
- 1:	16S rRNA (guanine(1207)-N(2))-methyltransferase [2.1.1.172]	(1|1)	(1|1|0)
- 1:	16S rRNA (guanine(1405)-N(7))-methyltransferase [2.1.1.179]	(0|0)	(0|0|0)
- 1:	16S rRNA (guanine(1516)-N(2))-methyltransferase [2.1.1.242]	(0|0)	(1|0|0)
- 1:	16S rRNA (guanine(527)-N(7))-methyltransferase [2.1.1.170]	(1|1)	(1|0|0)
- 1:	16S rRNA (guanine(966)-N(2))-methyltransferase [2.1.1.171]	(0|0)	(0|0|0)
- 1:	16S rRNA (uracil(1498)-N(3))-methyltransferase [2.1.1.193]	(2|2)	(2|1|0)
- 1:	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-d [2.1.1.183]	(0|1)	(0|0|0)
- 1:	2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7- [2.1.1.241]	(0|0)	(0|0|0)
- 1:	2,7,4'-trihydroxyisoflavanone 4'-O-methyltransfera [2.1.1.212]	(0|0)	(1|1|0)
- 1:	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [2.1.1.201]	(1|1)	(1|0|0)
- 1:	2-polyprenyl-6-hydroxyphenyl methylase [2.1.1.222]	(1|0)	(1|0|0)
- 1:	21S rRNA (uridine(2791)-2'-O-)-methyltransferase [2.1.1.168]	(0|0)	(0|0|0)
- 1:	23S rRNA (adenine(1618)-N(6))-methyltransferase [2.1.1.181]	(1|1)	(1|0|0)
- 1:	23S rRNA (adenine(2085)-N(6))-dimethyltransferase [2.1.1.184]	(0|1)	(0|0|0)
- 1:	23S rRNA (adenine(2503)-C(2))-methyltransferase [2.1.1.192]	(1|1)	(1|0|0)
- 1:	23S rRNA (adenine(2503)-C(8))-methyltransferase [2.1.1.224]	(1|0)	(1|0|0)
- 1:	23S rRNA (adenosine(1067)-2'-O)-methyltransferase [2.1.1.230]	(0|0)	(0|0|0)
- 1:	23S rRNA (cytidine(1920)-2'-O)-methyltransferase [2.1.1.226]	(0|0)	(0|0|0)
- 1:	23S rRNA (cytidine(2498)-2'-O)-methyltransferase [2.1.1.186]	(1|1)	(1|0|0)
- 1:	23S rRNA (cytosine(1962)-C(5))-methyltransferase [2.1.1.191]	(2|2)	(2|1|0)
- 1:	23S rRNA (guanine(1835)-N(2))-methyltransferase [2.1.1.174]	(1|1)	(1|0|0)
- 1:	23S rRNA (guanine(2251)-2'-O)-methyltransferase [2.1.1.185]	(2|2)	(2|1|0)
- 1:	23S rRNA (guanine(2445)-N(2))-methyltransferase [2.1.1.173]	(1|1)	(1|1|0)
- 1:	23S rRNA (guanine(2535)-N(1))-methyltransferase [2.1.1.209]	(0|0)	(0|0|0)
- 1:	23S rRNA (guanine(745)-N(1))-methyltransferase [2.1.1.187]	(0|0)	(0|0|0)
- 1:	23S rRNA (guanine(748)-N(1))-methyltransferase [2.1.1.188]	(0|0)	(0|0|0)
- 1:	23S rRNA (pseudouridine(1915)-N(3))-methyltransfer [2.1.1.177]	(1|1)	(1|0|0)
- 1:	23S rRNA (uracil(1939)-C(5))-methyltransferase [2.1.1.190]	(2|2)	(2|1|0)
- 1:	23S rRNA (uracil(747)-C(5))-methyltransferase [2.1.1.189]	(1|1)	(1|0|0)
- 1:	23S rRNA (uridine(2479)-2'-O)-methyltransferase [2.1.1.208]	(0|0)	(0|0|0)
- 1:	23S rRNA (uridine(2552)-2'-O-)-methyltransferase [2.1.1.166]	(1|1)	(1|1|0)
- 1:	24-methylenesterol C-methyltransferase [2.1.1.143]	(0|0)	(0|0|0)
- 1:	27S pre-rRNA (guanosine(2922)-2'-O-)-methyltransfe [2.1.1.167]	(0|0)	(0|0|0)
- 1:	3'-demethylstaurosporine O-methyltransferase [2.1.1.139]	(0|0)	(0|0|0)
- 1:	3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltran [2.1.1.116]	(0|0)	(0|0|0)
- 1:	3,7-dimethylquercetin 4'-O-methyltransferase [2.1.1.83]	(0|0)	(0|0|0)
- 1:	3-demethylubiquinol 3-O-methyltransferase [2.1.1.64]	(1|0)	(1|0|0)
- 1:	3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-meth [2.1.1.99]	(0|0)	(0|0|0)
- 1:	3-hydroxyanthranilate 4-C-methyltransferase [2.1.1.97]	(0|0)	(0|0|0)
- 1:	3-methylquercetin 7-O-methyltransferase [2.1.1.82]	(0|0)	(0|0|0)
- 1:	5-hydroxyfuranocoumarin 5-O-methyltransferase [2.1.1.69]	(0|0)	(0|0|0)
- 1:	5-methyltetrahydropteroyltriglutamate--homocystein [2.1.1.14]	(1|1)	(1|1|0)
- 1:	5-pentadecatrienyl resorcinol O-methyltransferase [2.1.1.n7]	(0|0)	(0|0|0)
- 1:	6-O-methylnorlaudanosoline 5'-O-methyltransferase [2.1.1.121]	(0|0)	(0|0|0)
- 1:	6-hydroxymellein O-methyltransferase [2.1.1.108]	(0|0)	(0|0|0)
- 1:	7-methylxanthosine synthase [2.1.1.158]	(0|0)	(0|0|0)
- 1:	8-hydroxyfuranocoumarin 8-O-methyltransferase [2.1.1.70]	(0|0)	(0|0|0)
- 1:	8-hydroxyquercetin 8-O-methyltransferase [2.1.1.88]	(0|0)	(0|0|0)
- 1:	Acetylserotonin O-methyltransferase [2.1.1.4]	(1|1)	(1|1|0)
- 1:	Amine N-methyltransferase [2.1.1.49]	(0|0)	(0|0|0)
- 1:	Anthranilate N-methyltransferase [2.1.1.111]	(0|0)	(0|0|0)
- 1:	Apigenin 4'-O-methyltransferase [2.1.1.75]	(0|0)	(0|0|0)
- 1:	Arsenite methyltransferase [2.1.1.137]	(0|0)	(0|0|0)
- 1:	Betaine--homocysteine S-methyltransferase [2.1.1.5]	(1|1)	(1|0|0)
- 1:	Caffeate O-methyltransferase [2.1.1.68]	(1|2)	(1|1|0)
- 1:	Caffeine synthase [2.1.1.160]	(0|1)	(0|0|0)
- 1:	Caffeoyl-CoA O-methyltransferase [2.1.1.104]	(0|1)	(0|0|0)
- 1:	Calmodulin-lysine N-methyltransferase [2.1.1.60]	(0|0)	(0|0|0)
- 1:	Carnosine N-methyltransferase [2.1.1.22]	(0|0)	(0|0|0)
- 1:	Catechol O-methyltransferase [2.1.1.6]	(0|1)	(0|0|0)
- 1:	Chlorophenol O-methyltransferase [2.1.1.136]	(0|0)	(0|0|0)
- 1:	Cobalt-factor II C(20)-methyltransferase [2.1.1.151]	(0|0)	(0|0|0)
- 1:	Cobalt-precorrin-5B (C(1))-methyltransferase [2.1.1.195]	(0|0)	(0|0|0)
- 1:	Cobalt-precorrin-7 (C(15))-methyltransferase (deca [2.1.1.196]	(0|0)	(0|0|0)
- 1:	Columbamine O-methyltransferase [2.1.1.118]	(0|0)	(0|0|0)
- 1:	Corydaline synthase [2.1.1.147]	(0|0)	(0|0|0)
- 1:	Cycloartenol 24-C-methyltransferase [2.1.1.142]	(0|0)	(0|0|0)
- 1:	Cyclopropane-fatty-acyl-phospholipid synthase [2.1.1.79]	(0|1)	(0|0|0)
- 1:	DNA (cytosine-5-)-methyltransferase [2.1.1.37]	(3|3)	(4|2|0)
- 1:	Deleted entry [2.1.1.30]	(0|0)	(0|0|0)
- 1:	Deleted entry [2.1.1.138]	(0|0)	(0|0|0)
- 1:	Deleted entry [2.1.1.194]	(0|0)	(0|0|0)
- 1:	Demethylmacrocin O-methyltransferase [2.1.1.102]	(0|0)	(0|0|0)
- 1:	Demethylmenaquinone methyltransferase [2.1.1.163]	(1|1)	(1|0|0)
- 1:	Demethylrebeccamycin-D-glucose O-methyltransferase [2.1.1.164]	(0|0)	(0|0|0)
- 1:	Demethylspheroidene O-methyltransferase [2.1.1.210]	(0|0)	(0|0|0)
- 1:	Demethylsterigmatocystin 6-O-methyltransferase [2.1.1.109]	(0|0)	(0|0|0)
- 1:	Deoxycytidylate C-methyltransferase [2.1.1.54]	(0|0)	(0|0|0)
- 1:	Dimethylglycine N-methyltransferase [2.1.1.161]	(0|0)	(0|0|0)
- 1:	Dimethylhistidine N-methyltransferase [2.1.1.44]	(0|0)	(0|0|0)
- 1:	Diphthine synthase [2.1.1.98]	(1|1)	(1|0|0)
- 1:	Fatty-acid O-methyltransferase [2.1.1.15]	(0|0)	(0|0|0)
- 1:	Flavone 3'-O-methyltransferase [2.1.1.42]	(0|0)	(0|0|0)
- 1:	Flavonoid 4'-O-methyltransferase [2.1.1.231]	(0|0)	(0|0|0)
- 1:	Geranyl diphosphate 2-C-methyltransferase [2.1.1.n6]	(0|0)	(0|0|0)
- 1:	Glucuronoxylan 4-O-methyltransferase [2.1.1.112]	(0|0)	(0|0|0)
- 1:	Glycine N-methyltransferase [2.1.1.20]	(0|1)	(0|0|0)
- 1:	Glycine/sarcosine N-methyltransferase [2.1.1.156]	(0|0)	(0|0|0)
- 1:	Glycine/sarcosine/dimethylglycine N-methyltransfer [2.1.1.162]	(0|0)	(0|0|0)
- 1:	Guanidinoacetate N-methyltransferase [2.1.1.2]	(0|1)	(0|0|0)
- 1:	Histamine N-methyltransferase [2.1.1.8]	(0|1)	(0|0|0)
- 1:	Histone-arginine N-methyltransferase [2.1.1.125]	(1|1)	(2|2|0)
- 1:	Histone-lysine N-methyltransferase [2.1.1.43]	(15|14)	(17|14|4)
- 1:	Homocysteine S-methyltransferase [2.1.1.10]	(1|1)	(1|0|0)
- 1:	Indolepyruvate C-methyltransferase [2.1.1.47]	(0|0)	(0|0|0)
- 1:	Inositol 1-methyltransferase [2.1.1.40]	(0|0)	(0|0|0)
- 1:	Inositol 3-methyltransferase [2.1.1.39]	(0|0)	(0|0|0)
- 1:	Inositol 4-methyltransferase [2.1.1.129]	(0|0)	(0|0|0)
- 1:	Iodophenol O-methyltransferase [2.1.1.26]	(0|0)	(0|0|0)
- 1:	Isobutyraldoxime O-methyltransferase [2.1.1.91]	(0|0)	(0|0|0)
- 1:	Isoflavone 4'-O-methyltransferase [2.1.1.46]	(0|0)	(1|1|0)
- 1:	Isoflavone 7-O-methyltransferase [2.1.1.150]	(0|0)	(1|1|0)
- 1:	Isoliquiritigenin 2'-O-methyltransferase [2.1.1.154]	(0|0)	(0|0|0)
- 1:	Isoorientin 3'-O-methyltransferase [2.1.1.78]	(0|0)	(0|0|0)
- 1:	Jasmonate O-methyltransferase [2.1.1.141]	(0|0)	(0|0|0)
- 1:	Kaempferol 4'-O-methyltransferase [2.1.1.155]	(0|0)	(0|0|0)
- 1:	L-olivosyl-oleandolide 3-O-methyltransferase [2.1.1.239]	(0|0)	(0|0|0)
- 1:	Licodione 2'-O-methyltransferase [2.1.1.65]	(0|0)	(0|0|0)
- 1:	Loganate O-methyltransferase [2.1.1.50]	(0|0)	(0|0|0)
- 1:	Macrocin O-methyltransferase [2.1.1.101]	(0|0)	(0|0|0)
- 1:	Magnesium protoporphyrin IX methyltransferase [2.1.1.11]	(0|0)	(0|0|0)
- 1:	Malonyl-CoA O-methyltransferase [2.1.1.197]	(2|0)	(2|1|0)
- 1:	Methanol--5-hydroxybenzimidazolylcobamide Co-methy [2.1.1.90]	(0|0)	(0|0|0)
- 1:	Methionine S-methyltransferase [2.1.1.12]	(0|0)	(1|2|1)
- 1:	Methionine synthase [2.1.1.13]	(5|5)	(5|4|3)
- 1:	Methyl halide transferase [2.1.1.165]	(0|0)	(0|0|0)
- 1:	Methylamine--glutamate N-methyltransferase [2.1.1.21]	(0|0)	(0|0|0)
- 1:	Methylated-DNA--[protein]-cysteine S-methyltransfe [2.1.1.63]	(2|2)	(2|1|0)
- 1:	Methylene-fatty-acyl-phospholipid synthase [2.1.1.16]	(0|0)	(0|0|0)
- 1:	Methylquercetagetin 6-O-methyltransferase [2.1.1.84]	(0|0)	(0|0|0)
- 1:	Multisite-specific tRNA:(cytosine-C(5))-methyltran [2.1.1.202]	(0|0)	(0|0|0)
- 1:	Mycinamicin III 3''-O-methyltransferase [2.1.1.237]	(0|0)	(0|0|0)
- 1:	Mycinamicin VI 2''-O-methyltransferase [2.1.1.238]	(0|0)	(0|0|0)
- 1:	Myricetin O-methyltransferase [2.1.1.149]	(0|0)	(0|0|0)
- 1:	N,N-dimethyltransferase [2.1.1.234]	(0|0)	(0|0|0)
- 1:	N-benzoyl-4-hydroxyanthranilate 4-O-methyltransfer [2.1.1.105]	(0|0)	(0|0|0)
- 1:	N-terminal protein methyltransferase [2.1.1.n5]	(0|1)	(0|0|0)
- 1:	Naringenin 7-O-methyltransferase [2.1.1.232]	(0|0)	(0|0|0)
- 1:	Nicotinamide N-methyltransferase [2.1.1.1]	(0|0)	(0|0|0)
- 1:	Nicotinate N-methyltransferase [2.1.1.7]	(0|0)	(0|0|0)
- 1:	O-demethylpuromycin O-methyltransferase [2.1.1.38]	(0|0)	(0|0|0)
- 1:	Phenol O-methyltransferase [2.1.1.25]	(0|0)	(0|0|0)
- 1:	Phenylethanolamine N-methyltransferase [2.1.1.28]	(0|1)	(0|0|0)
- 1:	Phosphatidyl-N-methylethanolamine N-methyltransfer [2.1.1.71]	(0|0)	(0|0|0)
- 1:	Phosphatidylethanolamine N-methyltransferase [2.1.1.17]	(0|0)	(0|0|0)
- 1:	Phosphoethanolamine N-methyltransferase [2.1.1.103]	(0|0)	(0|1|0)
- 1:	Polyprenyldihydroxybenzoate methyltransferase [2.1.1.114]	(0|0)	(0|0|0)
- 1:	Polysaccharide O-methyltransferase [2.1.1.18]	(0|0)	(0|0|0)
- 1:	Precorrin-2 C(20)-methyltransferase [2.1.1.130]	(0|0)	(1|0|0)
- 1:	Precorrin-3B C(17)-methyltransferase [2.1.1.131]	(0|0)	(0|0|0)
- 1:	Precorrin-4 C(11)-methyltransferase [2.1.1.133]	(1|1)	(1|0|0)
- 1:	Precorrin-6A synthase (deacetylating) [2.1.1.152]	(0|0)	(0|0|0)
- 1:	Precorrin-6Y C(5,15)-methyltransferase (decarboxyl [2.1.1.132]	(0|0)	(1|1|0)
- 1:	Protein-L-isoaspartate(D-aspartate) O-methyltransf [2.1.1.77]	(1|1)	(1|0|0)
- 1:	Protein-S-isoprenylcysteine O-methyltransferase [2.1.1.100]	(0|0)	(0|0|0)
- 1:	Protein-glutamate O-methyltransferase [2.1.1.80]	(1|2)	(1|1|0)
- 1:	Protein-histidine N-methyltransferase [2.1.1.85]	(0|0)	(0|0|0)
- 1:	Putrescine N-methyltransferase [2.1.1.53]	(0|0)	(0|0|0)
- 1:	Pyridine N-methyltransferase [2.1.1.87]	(0|0)	(0|0|0)
- 1:	Quercetin 3-O-methyltransferase [2.1.1.76]	(0|0)	(1|1|0)
- 1:	Resorcinol O-methyltransferase [2.1.1.n1]	(0|0)	(0|0|0)
- 1:	Sarcosine/dimethylglycine N-methyltransferase [2.1.1.157]	(0|0)	(0|0|0)
- 1:	Selenocysteine Se-methyltransferase [2.1.1.n3]	(0|0)	(0|0|0)
- 1:	Site-specific DNA-methyltransferase (adenine-speci [2.1.1.72]	(1|3)	(1|0|0)
- 1:	Site-specific DNA-methyltransferase (cytosine-N(4) [2.1.1.113]	(0|1)	(0|1|0)
- 1:	Sterigmatocystin 8-O-methyltransferase [2.1.1.110]	(0|0)	(0|0|0)
- 1:	Sterol 24-C-methyltransferase [2.1.1.41]	(0|0)	(0|0|0)
- 1:	Tabersonine 16-O-methyltransferase [2.1.1.94]	(0|0)	(0|0|0)
- 1:	Tetrahydrocolumbamine 2-O-methyltransferase [2.1.1.89]	(0|0)	(0|0|0)
- 1:	Tetrahydromethanopterin S-methyltransferase [2.1.1.86]	(1|0)	(1|0|0)
- 1:	Theobromine synthase [2.1.1.159]	(0|0)	(0|0|0)
- 1:	Thetin--homocysteine S-methyltransferase [2.1.1.3]	(0|0)	(0|0|0)
- 1:	Thiocyanate methyltransferase [2.1.1.n4]	(0|0)	(0|0|0)
- 1:	Thioether S-methyltransferase [2.1.1.96]	(0|0)	(0|0|0)
- 1:	Thiol S-methyltransferase [2.1.1.9]	(0|0)	(0|0|0)
- 1:	Thiopurine S-methyltransferase [2.1.1.67]	(1|1)	(1|0|0)
- 1:	Thymidylate synthase [2.1.1.45]	(2|2)	(2|1|0)
- 1:	Thymidylate synthase (FAD) [2.1.1.148]	(1|1)	(1|0|0)
- 1:	Tocopherol O-methyltransferase [2.1.1.95]	(0|0)	(0|0|0)
- 1:	Trans-aconitate 2-methyltransferase [2.1.1.144]	(1|0)	(1|0|0)
- 1:	Trans-aconitate 3-methyltransferase [2.1.1.145]	(0|0)	(0|0|0)
- 1:	Trans-resveratrol di-O-methyltransferase [2.1.1.240]	(0|0)	(0|0|0)
- 1:	Transferred entry: 1.16.1.8 [2.1.1.135]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.124, 2.1.1.125 and 2.1.1. [2.1.1.23]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.129 [2.1.1.134]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.171, 2.1.1.172, 2.1.1.173 [2.1.1.52]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.181, 2.1.1.182, 2.1.1.183 [2.1.1.48]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.187 and 2.1.1.188 [2.1.1.51]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.202, 2.1.1.203 and 2.1.1. [2.1.1.29]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.211 [2.1.1.n2]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.213, 2.1.1.214, 2.1.1.215 [2.1.1.32]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.217, 2.1.1.218, 2.1.1.219 [2.1.1.36]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.221 and 2.1.1.228 [2.1.1.31]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.37 [2.1.1.73]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.49 [2.1.1.81]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.57 [2.1.1.58]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.69 [2.1.1.92]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.70 [2.1.1.93]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.1.1.77, 2.1.1.80 and 2.1.1.10 [2.1.1.24]	(0|0)	(0|0|0)
- 1:	Tricetin 3',4',5'-O-trimethyltransferase [2.1.1.169]	(0|0)	(0|0|0)
- 1:	Tricin synthase [2.1.1.175]	(0|0)	(0|0|0)
- 1:	Trimethylsulfonium--tetrahydrofolate N-methyltrans [2.1.1.19]	(0|0)	(0|0|0)
- 1:	Tryptophan 2-C-methyltransferase [2.1.1.106]	(0|0)	(0|0|0)
- 1:	Tyramine N-methyltransferase [2.1.1.27]	(0|0)	(0|0|0)
- 1:	Uroporphyrinogen-III C-methyltransferase [2.1.1.107]	(3|3)	(3|2|1)
- 1:	Vitexin 2''-O-rhamnoside 7-O-methyltransferase [2.1.1.153]	(0|0)	(0|0|0)
- 1:	[Cytochrome c]-arginine N-methyltransferase [2.1.1.124]	(0|0)	(0|0|0)
- 1:	[Cytochrome c]-lysine N-methyltransferase [2.1.1.59]	(0|0)	(1|0|0)
- 1:	[Cytochrome c]-methionine S-methyltransferase [2.1.1.123]	(0|0)	(0|0|0)
- 1:	[Myelin basic protein]-arginine N-methyltransferas [2.1.1.126]	(0|1)	(0|1|0)
- 1:	[Phosphatase 2A protein]-leucine-carboxy methyltra [2.1.1.233]	(0|1)	(0|0|0)
- 1:	[Ribulose-bisphosphate carboxylase]-lysine N-methy [2.1.1.127]	(0|0)	(2|1|0)
- 1:	dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N [2.1.1.236]	(0|0)	(0|0|0)
- 1:	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N [2.1.1.235]	(0|0)	(0|0|0)
- 1:	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferas [2.1.1.62]	(0|0)	(0|0|0)
- 1:	mRNA (guanine-N(7)-)-methyltransferase [2.1.1.56]	(7|8)	(9|5|1)
- 1:	mRNA (nucleoside-2'-O-)-methyltransferase [2.1.1.57]	(7|7)	(7|4|1)
- 1:	rRNA (adenosine-2'-O-)-methyltransferase [2.1.1.66]	(0|0)	(0|0|0)
- 1:	tRNA (5-methylaminomethyl-2-thiouridylate)-methylt [2.1.1.61]	(3|0)	(3|3|1)
- 1:	tRNA (adenine(22)-N(1))-methyltransferase [2.1.1.217]	(0|0)	(0|0|0)
- 1:	tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltra [2.1.1.219]	(0|0)	(0|0|0)
- 1:	tRNA (adenine(58)-N(1))-methyltransferase [2.1.1.220]	(0|1)	(0|0|0)
- 1:	tRNA (adenine(9)-N(1))-methyltransferase [2.1.1.218]	(0|0)	(0|0|0)
- 1:	tRNA (adenine-N(6)-)-methyltransferase [2.1.1.55]	(0|0)	(0|0|0)
- 1:	tRNA (carboxymethyluridine(34)-5-O)-methyltransfer [2.1.1.229]	(2|2)	(2|2|1)
- 1:	tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltrans [2.1.1.205]	(0|0)	(0|0|0)
- 1:	tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransfe [2.1.1.200]	(1|0)	(1|0|0)
- 1:	tRNA (cytidine(34)-2'-O)-methyltransferase [2.1.1.207]	(1|1)	(1|0|0)
- 1:	tRNA (cytidine(56)-2'-O)-methyltransferase [2.1.1.206]	(1|1)	(2|1|0)
- 1:	tRNA (cytosine(34)-C(5))-methyltransferase [2.1.1.203]	(0|1)	(0|0|0)
- 1:	tRNA (cytosine(38)-C(5))-methyltransferase [2.1.1.204]	(0|0)	(0|0|0)
- 1:	tRNA (guanine(10)-N(2))-dimethyltransferase [2.1.1.213]	(0|0)	(1|1|0)
- 1:	tRNA (guanine(10)-N(2))-methyltransferase [2.1.1.214]	(0|0)	(0|0|0)
- 1:	tRNA (guanine(26)-N(2))-dimethyltransferase [2.1.1.216]	(1|1)	(1|0|0)
- 1:	tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethylt [2.1.1.215]	(0|0)	(0|0|0)
- 1:	tRNA (guanine(37)-N(1))-methyltransferase [2.1.1.228]	(2|2)	(2|2|0)
- 1:	tRNA (guanine(46)-N(7))-methyltransferase [2.1.1.33]	(1|2)	(1|0|0)
- 1:	tRNA (guanine(9)-N(1))-methyltransferase [2.1.1.221]	(0|0)	(0|0|0)
- 1:	tRNA (guanosine(18)-2'-O)-methyltransferase [2.1.1.34]	(0|0)	(1|0|0)
- 1:	tRNA (uracil(54)-C(5))-methyltransferase [2.1.1.35]	(1|1)	(1|0|0)
- 1:	tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase [2.1.1.223]	(1|0)	(1|0|0)
- 1:	tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase [2.1.1.211]	(0|0)	(0|0|0)
- 1:	tRNA:m(4)X modification enzyme [2.1.1.225]	(0|0)	(0|0|0)

---

Superfamily

Superfamily domains annotated to this EC term (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
L30e-like	0	DIRECT
Methylated DNA-protein cysteine methyltransferase, C-terminal domain	0	DIRECT
Methionine synthase domain	0	DIRECT
Methylated DNA-protein cysteine methyltransferase domain	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
FYVE/PHD zinc finger	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Chemotaxis receptor methyltransferase CheR, N-terminal domain	0	DIRECT
Methionine synthase activation domain-like	0	DIRECT
Putative methyltransferase TM0872, insert domain	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
UROD/MetE-like	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Thymidylate synthase-complementing protein Thy1	0	DIRECT
SET domain	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Siroheme synthase middle domains-like	0	DIRECT
DNA-binding domain	0	DIRECT
NusB-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
alpha/beta knot	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
WW domain	0.000000000000005085	DIRECT
RNA-binding domain, RBD	0.000000000000009651	DIRECT
Tudor/PWWP/MBT	0.00000000000008783	DIRECT
Cobalamin (vitamin B12)-binding domain	0.0000000000005801	DIRECT
Chromo domain-like	0.0000000003649	DIRECT
beta-beta-alpha zinc fingers	0.0000000003713	DIRECT
HMG-box	0.000000002065	DIRECT
PUA domain-like	0.00000008075	DIRECT
Dihydrofolate reductase-like	0.000001304	DIRECT
Dihydropteroate synthetase-like	0.000003249	DIRECT
FAD-linked reductases, C-terminal domain	0.00001959	DIRECT
Nucleotide-binding domain	0.00004935	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0.0001651	DIRECT
E set domains	0.002849	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Bromodomain	0.01673	INHERITED FROM: Histone-lysine N-methyltransferase
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0.05007	INHERITED FROM: tRNA (guanine(37)-N(1))-methyltransferase
TPR-like	0.1514	INHERITED FROM: Histone-lysine N-methyltransferase
Trypsin-like serine proteases	0.3112	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
"Winged helix" DNA-binding domain	0.6492	INHERITED FROM: Caffeate O-methyltransferase || Acetylserotonin O-methyltransferase
DNA/RNA polymerases	1	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Clavaminate synthase-like	1	INHERITED FROM: tRNA (carboxymethyluridine(34)-5-O)-methyltransfer
alpha/beta-Hydrolases	1	INHERITED FROM: Malonyl-CoA O-methyltransferase
Nucleic acid-binding proteins	1	INHERITED FROM: 23S rRNA (uracil(1939)-C(5))-methyltransferase
NAD(P)-binding Rossmann-fold domains	1	INHERITED FROM: Uroporphyrinogen-III C-methyltransferase

---

Family

Family domains annotated to this (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Siroheme synthase middle domains-like	0	DIRECT
Class II viral fusion proteins C-terminal domain	0	DIRECT
Methyltetrahydrofolate-utiluzing methyltransferases	0	DIRECT
mRNA cap (Guanine N-7) methyltransferase	0	DIRECT
TRAM domain	0	DIRECT
Thiopurine S-methyltransferase	0	DIRECT
PHD domain	0	DIRECT
Leucine carboxy methyltransferase Ppm1	0	DIRECT
Glucose-inhibited division protein B (GidB)	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Protein-L-isoaspartyl O-methyltransferase	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
Salicylic acid carboxyl methyltransferase (SAMT)	0	DIRECT
Viral proteases	0	DIRECT
SpoU-like RNA 2'-O ribose methyltransferase	0	DIRECT
RNA helicase	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Plant O-methyltransferase, N-terminal domain	0	DIRECT
N6 adenine-specific DNA methylase, DAM	0	DIRECT
WW domain	0	DIRECT
UbiE/COQ5-like	0	DIRECT
Putative methyltransferase TM0872, insert domain	0	DIRECT
MraW-like putative methyltransferases	0	DIRECT
RuBisCo LSMT catalytic domain	0	DIRECT
Methylated DNA-protein cysteine methyltransferase, C-terminal domain	0	DIRECT
Arginine methyltransferase	0	DIRECT
Methionine synthase SAM-binding domain	0	DIRECT
RmsB N-terminal domain-like	0	DIRECT
YggJ N-terminal domain-like	0	DIRECT
AD-003 protein-like	0	DIRECT
Methionine synthase domain	0	DIRECT
Cobalamin-independent methionine synthase	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
TRM1-like	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
COMT-like	0	DIRECT
MoCo biosynthesis proteins	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Met-10+ protein-like	0	DIRECT
Hypothetical protein MJ0882	0	DIRECT
Hypothetical RNA methyltransferase domain (HRMD)	0	DIRECT
tRNA(1-methyladenosine) methyltransferase-like	0	DIRECT
SRA domain-like	0	DIRECT
Mycolic acid cyclopropane synthase	0	DIRECT
Siroheme synthase N-terminal domain-like	0	DIRECT
Type II DNA methylase	0	DIRECT
Histamine methyltransferase	0	DIRECT
YbeA-like	0	DIRECT
Plant O-methyltransferase, C-terminal domain	0	DIRECT
hypothetical RNA methyltransferase	0	DIRECT
YggJ C-terminal domain-like	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
PWWP domain	0	DIRECT
Chemotaxis receptor methyltransferase CheR, N-terminal domain	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
rRNA adenine dimethylase-like	0	DIRECT
Guanidinoacetate methyltransferase	0	DIRECT
RNA 2'-O ribose methyltransferase substrate binding domain	0	DIRECT
N-6 DNA Methylase-like	0	DIRECT
N5-glutamine methyltransferase, HemK	0	DIRECT
tRNA(m1G37)-methyltransferase TrmD	0	DIRECT
Thymidylate synthase-complementing protein Thy1	0	DIRECT
Glycine N-methyltransferase	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Methylated DNA-protein cysteine methyltransferase domain	0	DIRECT
AF0751-like	0	DIRECT
TrmB-like	0	DIRECT
Methyltransferase 10 domain	0	DIRECT
mRNA cap methylase	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
(Uracil-5-)-methyltransferase	0	DIRECT
Chemotaxis receptor methyltransferase CheR, C-terminal domain	0	DIRECT
Chromo domain	3.476e-16	DIRECT
Cobalamin (vitamin B12)-binding domain	0.00000000000001073	DIRECT
RNA-dependent RNA-polymerase	0.0000000000005172	DIRECT
Dihydrofolate reductases	0.0000000002691	DIRECT
HMG-box	0.0000000003989	DIRECT
Canonical RBD	0.0000001778	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0.00002936	DIRECT
AlkB-like	0.00002936	DIRECT
Bromodomain	0.005645	INHERITED FROM: Histone-lysine N-methyltransferase

---

Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
L30e-like	0	DIRECT
KRAB domain (Kruppel-associated box)	0	DIRECT
SET domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Methylated DNA-protein cysteine methyltransferase, C-terminal domain	0	DIRECT
Thymidylate synthase-complementing protein Thy1	0	DIRECT
Methionine synthase activation domain-like	0	DIRECT
Methionine synthase domain	0	DIRECT
UROD/MetE-like	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Radical SAM enzymes	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
DNA-binding domain	0	DIRECT
Siroheme synthase middle domains-like	0	DIRECT
FYVE/PHD zinc finger	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
Methylated DNA-protein cysteine methyltransferase domain	0	DIRECT
Putative methyltransferase TM0872, insert domain	0	DIRECT
alpha/beta knot	0	DIRECT
NusB-like	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Chemotaxis receptor methyltransferase CheR, N-terminal domain	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
WW domain	0.000000000000004848	DIRECT
RNA-binding domain, RBD	0.00000000000001068	DIRECT
Tudor/PWWP/MBT	0.00000000000008892	DIRECT
Cobalamin (vitamin B12)-binding domain	0.0000000000005969	DIRECT
beta-beta-alpha zinc fingers	0.0000000003476	DIRECT
Chromo domain-like	0.0000000003858	DIRECT
HMG-box	0.000000001836	DIRECT
PUA domain-like	0.0000001274	DIRECT
Dihydrofolate reductase-like	0.000001371	DIRECT
Dihydropteroate synthetase-like	0.000003745	DIRECT
FAD-linked reductases, C-terminal domain	0.00002448	DIRECT
Nucleotide-binding domain	0.00004957	DIRECT
CYTH-like phosphatases	0.000136	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0.0001521	DIRECT
E set domains	0.003294	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Bromodomain	0.01582	INHERITED FROM: Histone-lysine N-methyltransferase
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0.04859	INHERITED FROM: tRNA (guanine(37)-N(1))-methyltransferase
TPR-like	0.1485	INHERITED FROM: Histone-lysine N-methyltransferase
Trypsin-like serine proteases	0.3273	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Ankyrin repeat	0.3635	INHERITED FROM: Histone-lysine N-methyltransferase
"Winged helix" DNA-binding domain	0.6126	INHERITED FROM: Acetylserotonin O-methyltransferase || Isoflavone 4'-O-methyltransferase || Quercetin 3-O-methyltransferase || Isoflavone 7-O-methyltransferase || Caffeate O-methyltransferase || (Iso)eugenol O-methyltransferase || 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransfera
lambda repressor-like DNA-binding domains	0.7911	INHERITED FROM: DNA (cytosine-5-)-methyltransferase
SH3-domain	0.9605	INHERITED FROM: Histone-arginine N-methyltransferase
NAD(P)-binding Rossmann-fold domains	1	INHERITED FROM: Uroporphyrinogen-III C-methyltransferase
DNA ligase/mRNA capping enzyme, catalytic domain	1	INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase
Nucleic acid-binding proteins	1	INHERITED FROM: 23S rRNA (uracil(1939)-C(5))-methyltransferase
HD-domain/PDEase-like	1	INHERITED FROM: tRNA (cytidine(56)-2'-O)-methyltransferase
THUMP domain-like	1	INHERITED FROM: tRNA (guanine(10)-N(2))-dimethyltransferase
PLP-dependent transferases	1	INHERITED FROM: Methionine S-methyltransferase
alpha/beta-Hydrolases	1	INHERITED FROM: Malonyl-CoA O-methyltransferase
P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Clavaminate synthase-like	1	INHERITED FROM: tRNA (carboxymethyluridine(34)-5-O)-methyltransfer
DNA/RNA polymerases	1	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54928,51197 54928 - RNA-binding domain, RBD 51197 - Clavaminate synthase-like	0	DIRECT
57903,63748 57903 - FYVE/PHD zinc finger 63748 - Tudor/PWWP/MBT	0	DIRECT
51726,51726 51726 - UROD/MetE-like 51726 - UROD/MetE-like	0	DIRECT
53335,51905 53335 - S-adenosyl-L-methionine-dependent methyltransferases 51905 - FAD/NAD(P)-binding domain	0	DIRECT
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains	0	DIRECT
47413,53335 47413 - lambda repressor-like DNA-binding domains 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
88697,75217 88697 - PUA domain-like 75217 - alpha/beta knot	0	DIRECT
82282,51717 82282 - Homocysteine S-methyltransferase 51717 - Dihydropteroate synthetase-like	0	DIRECT
54160,82199 54160 - Chromo domain-like 82199 - SET domain	0	DIRECT
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0	DIRECT
82199,57903 82199 - SET domain 57903 - FYVE/PHD zinc finger	0	DIRECT
143437,53335 143437 - THUMP domain-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
53597,55831 53597 - Dihydrofolate reductase-like 55831 - Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
88697,82199 88697 - PUA domain-like 82199 - SET domain	0	DIRECT
53335,50249 53335 - S-adenosyl-L-methionine-dependent methyltransferases 50249 - Nucleic acid-binding proteins	0	DIRECT
53335,53383 53335 - S-adenosyl-L-methionine-dependent methyltransferases 53383 - PLP-dependent transferases	0	DIRECT
53155,46767 53155 - Methylated DNA-protein cysteine methyltransferase domain 46767 - Methylated DNA-protein cysteine methyltransferase, C-terminal domain	0	DIRECT
54171,82199 54171 - DNA-binding domain 82199 - SET domain	0	DIRECT
53335,53335 53335 - S-adenosyl-L-methionine-dependent methyltransferases 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
53790,53335 53790 - Tetrapyrrole methylase 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
63748,82199 63748 - Tudor/PWWP/MBT 82199 - SET domain	0	DIRECT
55315,75217 55315 - L30e-like 75217 - alpha/beta knot	0	DIRECT
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0	DIRECT
75217,54593 75217 - alpha/beta knot 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
88697,53335 88697 - PUA domain-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases	0	DIRECT
51717,47644 51717 - Dihydropteroate synthetase-like 47644 - Methionine synthase domain	0	DIRECT
50044,53335 50044 - SH3-domain 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54160,53335 54160 - Chromo domain-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
53474,53335 53474 - alpha/beta-Hydrolases 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
53335,81799 53335 - S-adenosyl-L-methionine-dependent methyltransferases 81799 - Putative methyltransferase TM0872, insert domain	0	DIRECT
52242,56507 52242 - Cobalamin (vitamin B12)-binding domain 56507 - Methionine synthase activation domain-like	0	DIRECT
82199,81822 82199 - SET domain 81822 - RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
75615,53790 75615 - Siroheme synthase middle domains-like 53790 - Tetrapyrrole methylase	0	DIRECT
48403,82199 48403 - Ankyrin repeat 82199 - SET domain	0	DIRECT
46785,53335 46785 - "Winged helix" DNA-binding domain 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
48013,53335 48013 - NusB-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
47644,52242 47644 - Methionine synthase domain 52242 - Cobalamin (vitamin B12)-binding domain	0	DIRECT
47757,53335 47757 - Chemotaxis receptor methyltransferase CheR, N-terminal domain 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
82199,48452 82199 - SET domain 48452 - TPR-like	0	DIRECT
75217,75217 75217 - alpha/beta knot 75217 - alpha/beta knot	0	DIRECT
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	DIRECT
75217,109604 75217 - alpha/beta knot 109604 - HD-domain/PDEase-like	0	DIRECT
55154,56091 55154 - CYTH-like phosphatases 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
51197,53335 51197 - Clavaminate synthase-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
51735,75615 51735 - NAD(P)-binding Rossmann-fold domains 75615 - Siroheme synthase middle domains-like	0	DIRECT
82185,82199 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 82199 - SET domain	0	DIRECT
50249,53335 50249 - Nucleic acid-binding proteins 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0.000000000005033	DIRECT
51905,54373 51905 - FAD/NAD(P)-binding domain 54373 - FAD-linked reductases, C-terminal domain	0.00007626	DIRECT
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain	0.03161	INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methylt
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
53383,53383 53383 - PLP-dependent transferases 53383 - PLP-dependent transferases	1	INHERITED FROM: Methionine S-methyltransferase

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0	DIRECT
57903,57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0	DIRECT
51717,47644,52242 51717 - Dihydropteroate synthetase-like 47644 - Methionine synthase domain 52242 - Cobalamin (vitamin B12)-binding domain	0	DIRECT
54928,51197,53335 54928 - RNA-binding domain, RBD 51197 - Clavaminate synthase-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
82282,51717,47644 82282 - Homocysteine S-methyltransferase 51717 - Dihydropteroate synthetase-like 47644 - Methionine synthase domain	0	DIRECT
53335,51905,54373 53335 - S-adenosyl-L-methionine-dependent methyltransferases 51905 - FAD/NAD(P)-binding domain 54373 - FAD-linked reductases, C-terminal domain	0	DIRECT
57903,63748,82199 57903 - FYVE/PHD zinc finger 63748 - Tudor/PWWP/MBT 82199 - SET domain	0	DIRECT
47644,52242,56507 47644 - Methionine synthase domain 52242 - Cobalamin (vitamin B12)-binding domain 56507 - Methionine synthase activation domain-like	0	DIRECT
51735,75615,53790 51735 - NAD(P)-binding Rossmann-fold domains 75615 - Siroheme synthase middle domains-like 53790 - Tetrapyrrole methylase	0	DIRECT
63748,82199,57903 63748 - Tudor/PWWP/MBT 82199 - SET domain 57903 - FYVE/PHD zinc finger	0	DIRECT
53335,53383,53383 53335 - S-adenosyl-L-methionine-dependent methyltransferases 53383 - PLP-dependent transferases 53383 - PLP-dependent transferases	0	DIRECT