Acyltransferases

Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.

Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.

Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.

EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files (Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).

Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.

EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files (Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).

Superfamily

Family

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A presence/absence matrix is generated using protein domains and supradomains for all genomes in SUPERFAMILY. The RAxML software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0	DIRECT
81296,54001 81296 - E set domains 54001 - Cysteine proteinases	0	DIRECT
52210,51735 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
69593,47473 69593 - Glycerol-3-phosphate (1)-acyltransferase 47473 - EF-hand	0	DIRECT
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0	DIRECT
51569,89000 51569 - Aldolase 89000 - post-HMGL domain-like	0	DIRECT
53448,51161 53448 - Nucleotide-diphospho-sugar transferases 51161 - Trimeric LpxA-like enzymes	0	DIRECT
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like	0	DIRECT
57850,57933 57850 - RING/U-box 57933 - TAZ domain	0	DIRECT
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
46785,57903 46785 - "Winged helix" DNA-binding domain 57903 - FYVE/PHD zinc finger	0	DIRECT
52540,75138 52540 - P-loop containing nucleoside triphosphate hydrolases 75138 - HprK N-terminal domain-like	0	DIRECT
51230,52777 51230 - Single hybrid motif 52777 - CoA-dependent acyltransferases	0	DIRECT
52540,55729 52540 - P-loop containing nucleoside triphosphate hydrolases 55729 - Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
102114,55729 102114 - Radical SAM enzymes 55729 - Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
89000,110921 89000 - post-HMGL domain-like 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	0	DIRECT
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like	0	DIRECT
55729,47370 55729 - Acyl-CoA N-acyltransferases (Nat) 47370 - Bromodomain	0	DIRECT
57850,57850 57850 - RING/U-box 57850 - RING/U-box	0	DIRECT
55729,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 55729 - Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
51735,48256 51735 - NAD(P)-binding Rossmann-fold domains 48256 - Citrate synthase	0	DIRECT
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase	0	DIRECT
69593,56801 69593 - Glycerol-3-phosphate (1)-acyltransferase 56801 - Acetyl-CoA synthetase-like	0	DIRECT
53633,55729 53633 - Carbamate kinase-like 55729 - Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
49309,49309 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains	0	DIRECT
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0	DIRECT
51569,54909 51569 - Aldolase 54909 - Dimeric alpha+beta barrel	0	DIRECT
55729,46589 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm	0	DIRECT
54160,55729 54160 - Chromo domain-like 55729 - Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
51230,51230 51230 - Single hybrid motif 51230 - Single hybrid motif	0	DIRECT
75138,53659 75138 - HprK N-terminal domain-like 53659 - Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
55112,55112 55112 - Formylmethanofuran:tetrahydromethanopterin formyltransferase 55112 - Formylmethanofuran:tetrahydromethanopterin formyltransferase	0	DIRECT
53901,55718 53901 - Thiolase-like 55718 - SCP-like	0	DIRECT
46589,55729 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
54001,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains	0	DIRECT
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases	0.00000000009644	DIRECT
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases	0.0002122	DIRECT
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.007373	INHERITED FROM: Histone acetyltransferase \|\| Transferring groups other than amino-acyl groups
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0.03575	INHERITED FROM: Histone acetyltransferase \|\| Transferring groups other than amino-acyl groups
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0.2929	INHERITED FROM: Beta-ketoacyl-acyl-carrier-protein synthase I
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains	0.7303	INHERITED FROM: ATP citrate synthase \|\| Acyl groups converted into alkyl on transfer
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains	0.8757	INHERITED FROM: Fatty-acid synthase \|\| [Acyl-carrier-protein] S-malonyltransferase \|\| [Acyl-carrier-protein] S-acetyltransferase \|\| Beta-ketoacyl-acyl-carrier-protein synthase I
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	1	INHERITED FROM: Lysyltransferase \|\| Aminoacyltransferases
52467,52518 52467 - DHS-like NAD/FAD-binding domain 52518 - Thiamin diphosphate-binding fold (THDP-binding)	1	INHERITED FROM: Sulfoacetaldehyde acetyltransferase
52518,52467 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52467 - DHS-like NAD/FAD-binding domain	1	INHERITED FROM: Sulfoacetaldehyde acetyltransferase

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Acyltransferases

Superfamily

Family

Supra-domain (including individual superfamily)