DNA-directed DNA polymerase

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	root [root] <6>
+ + + 3:	Transferases [2] <10>	(363|551)	(398|460|240)
+ + 2:	Transferring phosphorous-containing groups [2.7] <13>	(220|294)	(251|300|176)
+ 1:	Nucleotidyltransferases [2.7.7] <86>	(89|111)	(98|96|59)
0:	DNA-directed DNA polymerase [2.7.7.7]	(21|27)	(23|27|21)

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Superfamily

Superfamily domains annotated to this EC term (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
AF1531-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
DNA-binding domain of retroviral integrase	0	DIRECT
Retrovirus capsid dimerization domain-like	0	DIRECT
Acid proteases	0	DIRECT
Ribonuclease H-like	0	DIRECT
DNA clamp	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
PHP domain-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Histone-fold	0	DIRECT
Retroviral matrix proteins	0	DIRECT
Retrovirus capsid protein, N-terminal core domain	0	DIRECT
PIN domain-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
N-terminal Zn binding domain of HIV integrase	0	DIRECT
PsbU/PolX domain-like	0	DIRECT
Homing endonucleases	0.0000000000002981	DIRECT
DNA polymerase beta, N-terminal domain-like	0.00000000001048	DIRECT

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Family

Family domains annotated to this (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DnaQ-like 3'-5' exonuclease	0	DIRECT
Ribonuclease H	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Retrovirus capsid protein C-terminal domain	0	DIRECT
AF1531-like	0	DIRECT
DNA polymerase I	0	DIRECT
N-terminal Zn binding domain of HIV integrase	0	DIRECT
Immunodeficiency virus matrix proteins	0	DIRECT
PHP domain	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
HTLV-II matrix protein	0	DIRECT
DNA polymerase III, beta subunit	0	DIRECT
DNA polymerase beta-like	0	DIRECT
Retroviral protease (retropepsin)	0	DIRECT
Reverse transcriptase	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Retroviral integrase, catalytic domain	0	DIRECT
Retrovirus capsid protein, N-terminal core domain	0	DIRECT
DNA-binding domain of retroviral integrase	0	DIRECT
DNA polymerase beta, N-terminal domain-like	0.000000000001565	DIRECT
Intein (protein splicing domain)	0.00000000005581	DIRECT
DNA polymerase beta-like, second domain	0.00000000008333	DIRECT
Extended AAA-ATPase domain	0.0000000001761	DIRECT

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Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
AF1531-like	0	DIRECT
N-terminal Zn binding domain of HIV integrase	0	DIRECT
Ribonuclease H-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Acid proteases	0	DIRECT
Retroviral matrix proteins	0	DIRECT
PsbU/PolX domain-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Histone-fold	0	DIRECT
DNA clamp	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
DNA-binding domain of retroviral integrase	0	DIRECT
DNA polymerase III chi subunit	0	DIRECT
PIN domain-like	0	DIRECT
Zinc finger domain of DNA polymerase-alpha	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Retrovirus capsid protein, N-terminal core domain	0	DIRECT
PHP domain-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Retrovirus capsid dimerization domain-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
Homing endonucleases	0.0000000000001783	DIRECT
DNA polymerase beta, N-terminal domain-like	0.000000000006111	DIRECT

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47353,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains	0	DIRECT
56672,90234 56672 - DNA/RNA polymerases 90234 - Zinc finger domain of DNA polymerase-alpha	0	DIRECT
57756,50630 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases	0	DIRECT
56672,51294 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain	0	DIRECT
50249,56300 50249 - Nucleic acid-binding proteins 56300 - Metallo-dependent phosphatases	0	DIRECT
55608,56672 55608 - Homing endonucleases 56672 - DNA/RNA polymerases	0	DIRECT
47943,47353 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like	0	DIRECT
50249,89550 50249 - Nucleic acid-binding proteins 89550 - PHP domain-like	0	DIRECT
55979,55979 55979 - DNA clamp 55979 - DNA clamp	0	DIRECT
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like	0	DIRECT
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like	0	DIRECT
53098,46919 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase	0	DIRECT
56672,55608 56672 - DNA/RNA polymerases 55608 - Homing endonucleases	0	DIRECT
56672,100879 56672 - DNA/RNA polymerases 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
47807,56672 47807 - 5' to 3' exonuclease, C-terminal subdomain 56672 - DNA/RNA polymerases	0	DIRECT
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	DIRECT
47807,53098 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like	0	DIRECT
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like	0	DIRECT
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases	0	DIRECT
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase	0	DIRECT
51294,56672 51294 - Hedgehog/intein (Hint) domain 56672 - DNA/RNA polymerases	0	DIRECT
89550,53098 89550 - PHP domain-like 53098 - Ribonuclease H-like	0	DIRECT
47836,47943 47836 - Retroviral matrix proteins 47943 - Retrovirus capsid protein, N-terminal core domain	0	DIRECT
53098,53098 53098 - Ribonuclease H-like 53098 - Ribonuclease H-like	0.0000000001068	DIRECT
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like	0.0000000002763	DIRECT
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0.0000000002763	DIRECT

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
88723,47807,56672 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain 56672 - DNA/RNA polymerases	0	DIRECT
53098,56672,51294 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain	0	DIRECT
53098,46919,53098 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like	0	DIRECT
57756,50630,56672 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases 56672 - DNA/RNA polymerases	0	DIRECT
55979,55979,55979 55979 - DNA clamp 55979 - DNA clamp 55979 - DNA clamp	0	DIRECT
51294,56672,55608 51294 - Hedgehog/intein (Hint) domain 56672 - DNA/RNA polymerases 55608 - Homing endonucleases	0	DIRECT
55608,56672,51294 55608 - Homing endonucleases 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain	0	DIRECT
53098,56672,90234 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases 90234 - Zinc finger domain of DNA polymerase-alpha	0	DIRECT
47836,47943,47353 47836 - Retroviral matrix proteins 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like	0	DIRECT
47943,47353,57756 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains	0	DIRECT
56672,53098,46919 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase	0	DIRECT
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase	0	DIRECT
56672,53098,50122 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase	0	DIRECT
47353,57756,50630 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases	0	DIRECT
47807,53098,56672 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	DIRECT
50249,89550,53098 50249 - Nucleic acid-binding proteins 89550 - PHP domain-like 53098 - Ribonuclease H-like	0	DIRECT
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like	0	DIRECT
88723,47807,53098 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like	0	DIRECT
56672,55608,56672 56672 - DNA/RNA polymerases 55608 - Homing endonucleases 56672 - DNA/RNA polymerases	0	DIRECT
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0.0000000002763	DIRECT
56672,53098,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 53098 - Ribonuclease H-like	0.000000001875	DIRECT