Metalloendopeptidases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + 3:	root [root] <6>
+ + 2:	Hydrolases [3] <13>	(329|528)	(368|389|207)
+ 1:	Acting on peptide bonds (peptide hydrolases) [3.4] <14>	(102|148)	(110|125|74)
0:	Metalloendopeptidases [3.4.24] <87>	(16|26)	(18|17|11)
- 1:	3.4.24.30, 3.4.24.31, 3.4.24.32, 3.4.24.39 and 3.4 [3.4.24.4]	(0|0)	(0|0|0)
- 1:	ADAM 17 endopeptidase [3.4.24.86]	(0|0)	(1|1|0)
- 1:	ADAM10 endopeptidase [3.4.24.81]	(1|2)	(1|1|0)
- 1:	ADAMTS-4 endopeptidase [3.4.24.82]	(1|2)	(1|1|0)
- 1:	ADAMTS13 endopeptidase [3.4.24.87]	(0|0)	(0|0|0)
- 1:	Adamalysin [3.4.24.46]	(0|0)	(0|0|0)
- 1:	Anthrax lethal factor endopeptidase [3.4.24.83]	(0|0)	(0|0|0)
- 1:	Astacin [3.4.24.21]	(1|2)	(1|2|1)
- 1:	Atrolysin A [3.4.24.1]	(0|0)	(0|0|0)
- 1:	Atrolysin B [3.4.24.41]	(0|0)	(0|0|0)
- 1:	Atrolysin C [3.4.24.42]	(0|0)	(0|0|0)
- 1:	Atrolysin E [3.4.24.44]	(0|0)	(0|0|0)
- 1:	Atrolysin F [3.4.24.45]	(0|0)	(0|0|0)
- 1:	Atroxase [3.4.24.43]	(0|0)	(0|0|0)
- 1:	Aureolysin [3.4.24.29]	(0|0)	(0|0|0)
- 1:	Bacillolysin [3.4.24.28]	(0|1)	(0|0|0)
- 1:	Beta-lytic metalloendopeptidase [3.4.24.32]	(0|0)	(0|0|0)
- 1:	Bontoxilysin [3.4.24.69]	(3|4)	(3|3|2)
- 1:	Bothrolysin [3.4.24.50]	(0|0)	(0|0|0)
- 1:	Bothropasin [3.4.24.49]	(0|0)	(0|0|0)
- 1:	Choriolysin H [3.4.24.67]	(0|0)	(0|0|0)
- 1:	Choriolysin L [3.4.24.66]	(0|0)	(0|0|0)
- 1:	Coccolysin [3.4.24.30]	(0|0)	(0|0|0)
- 1:	Dactylysin [3.4.24.60]	(0|0)	(0|0|0)
- 1:	Deleted entry [3.4.24.9]	(0|0)	(0|0|0)
- 1:	Deleted entry [3.4.24.2]	(0|0)	(0|0|0)
- 1:	Deleted entry [3.4.24.10]	(0|0)	(0|0|0)
- 1:	Deuterolysin [3.4.24.39]	(0|1)	(0|0|0)
- 1:	Endothelin-converting enzyme 1 [3.4.24.71]	(0|1)	(1|0|0)
- 1:	Envelysin [3.4.24.12]	(0|0)	(0|0|0)
- 1:	Fibrolase [3.4.24.72]	(0|0)	(0|0|0)
- 1:	Flavastacin [3.4.24.76]	(0|0)	(0|0|0)
- 1:	Fragilysin [3.4.24.74]	(0|0)	(0|0|0)
- 1:	GPR endopeptidase [3.4.24.78]	(1|1)	(1|0|0)
- 1:	Gametolysin [3.4.24.38]	(0|0)	(0|0|0)
- 1:	Gelatinase A [3.4.24.24]	(3|4)	(3|3|3)
- 1:	Gelatinase B [3.4.24.35]	(3|4)	(3|3|3)
- 1:	Horrilysin [3.4.24.47]	(0|0)	(0|0|0)
- 1:	IgA-specific metalloendopeptidase [3.4.24.13]	(0|0)	(0|0|0)
- 1:	Insulysin [3.4.24.56]	(1|1)	(1|1|1)
- 1:	Interstitial collagenase [3.4.24.7]	(2|3)	(2|2|1)
- 1:	Jararhagin [3.4.24.73]	(0|0)	(0|0|0)
- 1:	Leishmanolysin [3.4.24.36]	(0|1)	(0|0|0)
- 1:	Leucolysin [3.4.24.6]	(0|0)	(0|0|0)
- 1:	Lysostaphin [3.4.24.75]	(1|1)	(1|0|0)
- 1:	Macrophage elastase [3.4.24.65]	(0|0)	(2|2|1)
- 1:	Magnolysin [3.4.24.62]	(0|0)	(0|0|0)
- 1:	Matrilysin [3.4.24.23]	(0|0)	(1|1|0)
- 1:	Membrane-type matrix metalloproteinase-1 [3.4.24.80]	(2|3)	(2|2|1)
- 1:	Meprin A [3.4.24.18]	(0|0)	(3|2|1)
- 1:	Meprin B [3.4.24.63]	(0|0)	(2|2|1)
- 1:	Microbial collagenase [3.4.24.3]	(0|0)	(0|0|0)
- 1:	Mitochondrial intermediate peptidase [3.4.24.59]	(0|1)	(0|0|0)
- 1:	Mitochondrial processing peptidase [3.4.24.64]	(1|1)	(1|1|0)
- 1:	Mucrolysin [3.4.24.54]	(0|0)	(0|0|0)
- 1:	Mycolysin [3.4.24.31]	(0|0)	(0|0|0)
- 1:	Nardilysin [3.4.24.61]	(0|0)	(1|1|1)
- 1:	Neprilysin [3.4.24.11]	(0|1)	(0|0|0)
- 1:	Neurolysin [3.4.24.16]	(0|1)	(0|0|0)
- 1:	Neutrophil collagenase [3.4.24.34]	(0|0)	(2|2|1)
- 1:	O-sialoglycoprotein endopeptidase [3.4.24.57]	(0|0)	(0|0|0)
- 1:	Oligopeptidase A [3.4.24.70]	(0|0)	(0|0|0)
- 1:	Ophiolysin [3.4.24.51]	(0|0)	(0|0|0)
- 1:	Pappalysin-1 [3.4.24.79]	(0|0)	(0|0|0)
- 1:	Peptidyl-Asp metalloendopeptidase [3.4.24.33]	(0|0)	(0|0|0)
- 1:	Peptidyl-Lys metalloendopeptidase [3.4.24.20]	(0|0)	(0|0|0)
- 1:	Pitrilysin [3.4.24.55]	(1|1)	(1|1|1)
- 1:	Procollagen C-endopeptidase [3.4.24.19]	(0|0)	(0|0|0)
- 1:	Procollagen N-endopeptidase [3.4.24.14]	(0|0)	(1|2|1)
- 1:	Pseudolysin [3.4.24.26]	(0|0)	(0|0|0)
- 1:	Ruberlysin [3.4.24.48]	(0|0)	(0|0|0)
- 1:	Russellysin [3.4.24.58]	(0|0)	(0|0|0)
- 1:	S2P endopeptidase [3.4.24.85]	(1|0)	(1|0|0)
- 1:	Saccharolysin [3.4.24.37]	(0|0)	(0|0|0)
- 1:	Serralysin [3.4.24.40]	(1|2)	(1|1|0)
- 1:	Snapalysin [3.4.24.77]	(0|0)	(0|0|0)
- 1:	Ste24 endopeptidase [3.4.24.84]	(0|0)	(0|0|0)
- 1:	Stromelysin 1 [3.4.24.17]	(2|3)	(2|2|1)
- 1:	Stromelysin 2 [3.4.24.22]	(0|0)	(2|2|1)
- 1:	Tentoxilysin [3.4.24.68]	(0|0)	(0|0|0)
- 1:	Thermolysin [3.4.24.27]	(0|0)	(0|0|0)
- 1:	Thimet oligopeptidase [3.4.24.15]	(0|1)	(0|0|0)
- 1:	Transferred entry: 3.4.22.52, 3.4.22.53 and 3.4.25 [3.4.24.5]	(0|0)	(0|0|0)
- 1:	Transferred entry: 3.4.24.3 [3.4.24.8]	(0|0)	(0|0|0)
- 1:	Trimerelysin I [3.4.24.52]	(0|0)	(0|0|0)
- 1:	Trimerelysin II [3.4.24.53]	(0|0)	(0|0|0)
- 1:	Vibriolysin [3.4.24.25]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this EC term (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
STI-like	0	DIRECT
Clostridium neurotoxins, "coiled-coil" domain	0	DIRECT
beta-Roll	0	DIRECT
HybD-like	0	DIRECT
PGBD-like	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Hemopexin-like domain	0	DIRECT
TSP-1 type 1 repeat	0	DIRECT
Duplicated hybrid motif	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Spermadhesin, CUB domain	0.000000000008539	DIRECT
TRAF domain-like	0.0002316	DIRECT
Kringle-like	0.0002463	DIRECT
PDZ domain-like	0.3199	INHERITED FROM: S2P endopeptidase

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Family

Family domains annotated to this (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Serralysin-like metalloprotease, C-terminal domain	0	DIRECT
Serralysin-like metalloprotease, catalytic (N-terminal) domain	0	DIRECT
Clostridium neurotoxins, the second last domain	0	DIRECT
TNF-alpha converting enzyme, TACE, catalytic domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
Germination protease	0	DIRECT
Peptidoglycan hydrolase LytM	0	DIRECT
Clostridium neurotoxins, C-terminal domain	0	DIRECT
MPP-like	0	DIRECT
MMP N-terminal domain	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Reprolysin-like	0	DIRECT
Thermolysin-like	0	DIRECT
Clostridium neurotoxins, "coiled-coil" domain	0	DIRECT
Astacin	0	DIRECT
TSP-1 type 1 repeat	0	DIRECT
Fungal zinc peptidase	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Neurolysin-like	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
Clostridium neurotoxins, catalytic domain	0	DIRECT
Leishmanolysin	0	DIRECT
Fibronectin type II module	0.0000000000116	DIRECT
Spermadhesin, CUB domain	0.0000000002308	DIRECT
MAM domain	0.000001251	DIRECT
MATH domain	0.0001226	DIRECT

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Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
TSP-1 type 1 repeat	0	DIRECT
PGBD-like	0	DIRECT
Duplicated hybrid motif	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
HybD-like	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
STI-like	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
beta-Roll	0	DIRECT
Hemopexin-like domain	0	DIRECT
Clostridium neurotoxins, "coiled-coil" domain	0	DIRECT
Spermadhesin, CUB domain	0.000000000006468	DIRECT
TRAF domain-like	0.0001945	DIRECT
Kringle-like	0.0002064	DIRECT
EGF/Laminin	0.1581	INHERITED FROM: Meprin A
PDZ domain-like	0.2948	INHERITED FROM: S2P endopeptidase
S-adenosyl-L-methionine-dependent methyltransferases	1	INHERITED FROM: Endothelin-converting enzyme 1

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0	DIRECT
58091,49899 58091 - Clostridium neurotoxins, "coiled-coil" domain 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49899,50386 49899 - Concanavalin A-like lectins/glucanases 50386 - STI-like	0	DIRECT
55486,82895 55486 - Metalloproteases ("zincins"), catalytic domain 82895 - TSP-1 type 1 repeat	0	DIRECT
55486,49899 55486 - Metalloproteases ("zincins"), catalytic domain 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
55486,51120 55486 - Metalloproteases ("zincins"), catalytic domain 51120 - beta-Roll	0	DIRECT
82895,82895 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0	DIRECT
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0	DIRECT
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0	DIRECT
49854,82895 49854 - Spermadhesin, CUB domain 82895 - TSP-1 type 1 repeat	0	DIRECT
55486,58091 55486 - Metalloproteases ("zincins"), catalytic domain 58091 - Clostridium neurotoxins, "coiled-coil" domain	0	DIRECT
55486,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain	0	DIRECT
55486,57440 55486 - Metalloproteases ("zincins"), catalytic domain 57440 - Kringle-like	0	DIRECT
49899,49599 49899 - Concanavalin A-like lectins/glucanases 49599 - TRAF domain-like	0	DIRECT
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.0000004023	DIRECT
49854,49854 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0.00005913	DIRECT

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47090,55486,57440 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 57440 - Kringle-like	0	DIRECT
55486,58091,49899 55486 - Metalloproteases ("zincins"), catalytic domain 58091 - Clostridium neurotoxins, "coiled-coil" domain 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
55486,49899,49599 55486 - Metalloproteases ("zincins"), catalytic domain 49899 - Concanavalin A-like lectins/glucanases 49599 - TRAF domain-like	0	DIRECT
63411,63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0	DIRECT
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
82895,82895,82895 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0	DIRECT
58091,49899,50386 58091 - Clostridium neurotoxins, "coiled-coil" domain 49899 - Concanavalin A-like lectins/glucanases 50386 - STI-like	0	DIRECT
55486,49854,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	DIRECT
55486,57440,57440 55486 - Metalloproteases ("zincins"), catalytic domain 57440 - Kringle-like 57440 - Kringle-like	0	DIRECT
55486,49854,82895 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain 82895 - TSP-1 type 1 repeat	0	DIRECT
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.0000000005229	DIRECT