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Lyases
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Urocanase | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| FAH | 0 | DIRECT |
| NosL/MerB-like | 0 | DIRECT |
| IlvD/EDD N-terminal domain-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Chlorophyll a-b binding protein | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| IpsF-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Periplasmic binding protein-like I | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| Chelatase | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| Lysozyme-like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Chondroitin AC/alginate lyase | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| UraD-Like | 0.000000000001775 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0.00000000002037 | DIRECT |
| CoaB-like | 0.0000000002666 | DIRECT |
| Nitrile hydratase alpha chain | 0.00000000166 | DIRECT |
| SIS domain | 0.000000002477 | DIRECT |
| ClpP/crotonase | 0.000000003872 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000004208 | DIRECT |
| Methylglyoxal synthase-like | 0.000000004493 | DIRECT |
| NHL repeat | 0.0000001589 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000001589 | DIRECT |
| Electron transport accessory proteins | 0.000000752 | DIRECT |
| Chorismate mutase II | 0.000001266 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.000003428 | DIRECT |
| Serine metabolism enzymes domain | 0.00002634 | DIRECT |
| TATA-box binding protein-like | 0.0000344 | DIRECT |
| Periplasmic binding protein-like II | 0.00008606 | DIRECT |
| PHM/PNGase F | 0.00008747 | DIRECT |
| Tautomerase/MIF | 0.0002055 | DIRECT |
| ACT-like | 0.00038 | DIRECT |
| DHS-like NAD/FAD-binding domain | 0.003317 | INHERITED FROM: Pyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| Calcium-dependent phosphotriesterase | 0.00446 | INHERITED FROM: Carbon-nitrogen lyases || Amine-lyases |
| Starch-binding domain-like | 0.0163 | INHERITED FROM: Acting on polysaccharides || Carbon-oxygen lyases || Rhamnogalacturonan endolyase |
| MAPEG domain-like | 0.02354 | INHERITED FROM: Carbon-sulfur lyases || Leukotriene-C(4) synthase |
| Mss4-like | 0.02642 | INHERITED FROM: Carbon-sulfur lyases || S-(hydroxymethyl)glutathione synthase |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.03299 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || Carbon-carbon lyases |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04828 | INHERITED FROM: Carbon-oxygen lyases || Enoyl-CoA hydratase || Hydro-lyases |
| DNase I-like | 0.2093 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Carbon-oxygen lyases || Other carbon-oxygen lyases |
| CBS-domain pair | 0.239 | INHERITED FROM: Cystathionine beta-synthase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.3899 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Galactose mutarotase-like | 0.474 | INHERITED FROM: Acting on polysaccharides || Hyaluronate lyase || Rhamnogalacturonan endolyase |
| RmlC-like cupins | 0.5417 | INHERITED FROM: Peptidyl-glutamate 4-carboxylase || Ectoine synthase || Hydro-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.6132 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| Glutamine synthetase, N-terminal domain | 0.9467 | INHERITED FROM: Carboxy-lyases || Glutamate decarboxylase |
| Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| EPT/RTPC-like | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synth || Phosphorus-oxygen lyases |
| FabD/lysophospholipase-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Thioredoxin-like | 1 | INHERITED FROM: Carbon-halide lyases |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Galactose-binding domain-like | 1 | INHERITED FROM: Acting on polysaccharides || Rhamnogalacturonan endolyase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: D-lactate dehydratase || Anthranilate synthase || Oxo-acid-lyases || Indole-3-glycerol-phosphate synthase |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| "Winged helix" DNA-binding domain | 1 | INHERITED FROM: Alkylmercury lyase |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| ACP-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| HAD-like | 1 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase || Imidazoleglycerol-phosphate dehydratase || Hydro-lyases |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: Phosphorus-oxygen lyases || Guanylate cyclase |
| GroES-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Thiolase-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Cytochrome P450 | 1 | INHERITED FROM: Hydroperoxide dehydratase |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase || Pyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || 6-pyruvoyltetrahydropterin synthase |
| Ribokinase-like | 1 | INHERITED FROM: ATP-dependent NAD(P)H-hydrate dehydratase || Hydro-lyases |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Other carbon-oxygen lyases || 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxyl || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| GST C-terminal domain-like | 1 | INHERITED FROM: Carbon-halide lyases |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| PP2C-like | 1 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || 3-dehydroquinate dehydratase || Other lyases || 3-dehydroquinate synthase || Sirohydrochlorin ferrochelatase || GDP-mannose 4,6-dehydratase || UDP-glucuronate decarboxylase || Enoyl-CoA hydratase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || Ornithine cyclodeaminase |
| PLP-dependent transferases | 1 | INHERITED FROM: Threonine-phosphate decarboxylase || Selenocysteine lyase || Tyrosine decarboxylase || Other carbon-carbon lyases || Tryptophanase || Cystathionine beta-lyase || Histidine decarboxylase || Carbon-sulfur lyases || Cysteine-S-conjugate beta-lyase || Tyrosine phenol-lyase || Carbon-carbon lyases || Sphinganine-1-phosphate aldolase || 1-aminocyclopropane-1-carboxylate synthase || Glutamate decarboxylase || Cystathionine gamma-lyase || Low-specificity L-threonine aldolase || Aromatic-L-amino-acid decarboxylase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| PLC-like phosphodiesterases | 1 | INHERITED FROM: Phosphatidylinositol diacylglycerol-lyase || Phosphorus-oxygen lyases |
| Glutamine synthetase/guanido kinase | 1 | INHERITED FROM: Glutamate decarboxylase |
| L domain-like | 1 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Urocanase | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
| HemD-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| PCD-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| S13-like H2TH domain | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Aldolase | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| FAH | 0 | Direct |
| NosL/MerB-like | 0 | Direct |
| IlvD/EDD N-terminal domain-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Chlorophyll a-b binding protein | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| IpsF-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Periplasmic binding protein-like I | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| RibA-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| Chelatase | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| Lysozyme-like | 0 | Direct |
| ADC-like | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Chondroitin AC/alginate lyase | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| ADC synthase | 0 | Direct |
| Pectin lyase-like | 0 | Direct |
| UraD-Like | 0.000000000001775 | Direct |
| AF0104/ALDC/Ptd012-like | 0.00000000002037 | Direct |
| CoaB-like | 0.0000000002666 | Direct |
| Nitrile hydratase alpha chain | 0.00000000166 | Direct |
| SIS domain | 0.000000002477 | Direct |
| ClpP/crotonase | 0.000000003872 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000004208 | Direct |
| Methylglyoxal synthase-like | 0.000000004493 | Direct |
| NHL repeat | 0.0000001589 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000001589 | Direct |
| Electron transport accessory proteins | 0.000000752 | Direct |
| Chorismate mutase II | 0.000001266 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.000003428 | Direct |
| Serine metabolism enzymes domain | 0.00002634 | Direct |
| TATA-box binding protein-like | 0.0000344 | Direct |
| Periplasmic binding protein-like II | 0.00008606 | Direct |
| PHM/PNGase F | 0.00008747 | Direct |
| Tautomerase/MIF | 0.0002055 | Direct |
| ACT-like | 0.00038 | Direct |
| DHS-like NAD/FAD-binding domain | 0.003317 | Inherited |
| Calcium-dependent phosphotriesterase | 0.00446 | Inherited |
| Starch-binding domain-like | 0.0163 | Inherited |
| MAPEG domain-like | 0.02354 | Inherited |
| Mss4-like | 0.02642 | Inherited |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.03299 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04828 | Inherited |
| DNase I-like | 0.2093 | Inherited |
| CBS-domain pair | 0.239 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.3899 | Inherited |
| Galactose mutarotase-like | 0.474 | Inherited |
| RmlC-like cupins | 0.5417 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.6132 | Inherited |
| Glutamine synthetase, N-terminal domain | 0.9467 | Inherited |
| Rudiment single hybrid motif | 1 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| FabD/lysophospholipase-like | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Galactose-binding domain-like | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| "Winged helix" DNA-binding domain | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| ACP-like | 1 | Inherited |
| HAD-like | 1 | Inherited |
| Protein kinase-like (PK-like) | 1 | Inherited |
| GroES-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
| Ribokinase-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
| PP2C-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| PLC-like phosphodiesterases | 1 | Inherited |
| Glutamine synthetase/guanido kinase | 1 | Inherited |
| L domain-like | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Rhamnogalacturonase B, RhgB, middle domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Chlorophyll a-b binding protein | 0 | DIRECT |
| FAH | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| Arginine decarboxylase | 0 | DIRECT |
| Dimeric chorismate mutase | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | DIRECT |
| Cyanase N-terminal domain | 0 | DIRECT |
| Uroporphyrinogen decarboxylase, UROD | 0 | DIRECT |
| HAL/PAL-like | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| Decarboxylase | 0 | DIRECT |
| IpsF-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| MaoC-like | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| lvD/EDD N-terminal domain-like | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| HpcH/HpaI aldolase | 0 | DIRECT |
| IlvD/EDD C-terminal domain-like | 0 | DIRECT |
| Middle domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Chorismate lyase | 0 | DIRECT |
| Alpha-acetolactate decarboxylase-like | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| Glyoxalase I (lactoylglutathione lyase) | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| Terpenoid cyclase C-terminal domain | 0 | DIRECT |
| Mevalonate 5-diphosphate decarboxylase | 0 | DIRECT |
| Beta-eliminating lyases | 0 | DIRECT |
| Allosteric threonine deaminase C-terminal domain | 0 | DIRECT |
| Ornithine decarboxylase major domain | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| Bacterial muramidase, catalytic domain | 0 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
| UxuA-like | 0 | DIRECT |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | DIRECT |
| Bacterial PLC | 0 | DIRECT |
| Endonuclease III | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| MerB N-terminal domain-like | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | DIRECT |
| DHN aldolase/epimerase | 0 | DIRECT |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | DIRECT |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| Dehydroquinate synthase, DHQS | 0 | DIRECT |
| Methylglyoxal synthase, MgsA | 0 | DIRECT |
| Autoinducer-2 production protein LuxS | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| HMGL-like | 0 | DIRECT |
| Enolase | 0 | DIRECT |
| Siroheme synthase N-terminal domain-like | 0 | DIRECT |
| Histidine decarboxylase | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | DIRECT |
| Terpenoid cyclase N-terminal domain | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| DmpG/LeuA communication domain-like | 0 | DIRECT |
| 6-pyruvoyl tetrahydropterin synthase | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Bacterial S-adenosylmethionine decarboxylase | 0 | DIRECT |
| CbiX-like | 0 | DIRECT |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Pectin lyase | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| Aristolochene/pentalenene synthase | 0 | DIRECT |
| L-arabinose binding protein-like | 0 | DIRECT |
| Alginate lyase A1-III | 0 | DIRECT |
| mono-SIS domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| AgoG-like | 0 | DIRECT |
| Tryptophan biosynthesis enzymes | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| MerB-like | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| H-NOX domain | 0 | DIRECT |
| Formaldehyde-activating enzyme, FAE | 0 | DIRECT |
| Trichodiene synthase | 0 | DIRECT |
| Phosphoenolpyruvate carboxylase | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| Pectate lyase-like | 0 | DIRECT |
| DJ-1/PfpI | 0 | DIRECT |
| YjeF C-terminal domain-like | 0 | DIRECT |
| Ferrochelatase | 0 | DIRECT |
| Hyaluronate lyase-like catalytic, N-terminal domain | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| RuBisCo, large subunit, C-terminal domain | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Hyaluronate lyase-like, central domain | 0 | DIRECT |
| Glutathione-dependent formaldehyde-activating enzyme, Gfa | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| Serine dehydratase beta chain-like | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0 | DIRECT |
| Class II FBP aldolase | 0 | DIRECT |
| D-glucarate dehydratase-like | 0 | DIRECT |
| Hypothetical protein VC1974 | 0 | DIRECT |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| PP1699/LP2961-like | 0 | DIRECT |
| UraD-like | 0.000000000002503 | DIRECT |
| Pyruvate oxidase and decarboxylase, middle domain | 0.00000000000514 | DIRECT |
| CoaB-like | 0.0000000003957 | DIRECT |
| Nitrile hydratase beta chain | 0.000000002064 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000002064 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000007824 | DIRECT |
| DNase I-like | 0.0000000344 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0.00000005526 | DIRECT |
| NHL repeat | 0.0000001813 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000001813 | DIRECT |
| Ornithine cyclodeaminase-like | 0.0000009382 | DIRECT |
| Acyl-carrier protein (ACP) | 0.000001696 | DIRECT |
| DNA repair glycosylase, N-terminal domain | 0.00003793 | DIRECT |
| Cystathionine synthase-like | 0.00005429 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0.00005788 | DIRECT |
| DNA repair glycosylase, 2 C-terminal domains | 0.0001623 | DIRECT |
| MIF-related | 0.0001658 | DIRECT |
| Shikimate kinase (AroK) | 0.0001741 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.001397 | INHERITED FROM: Carbon-oxygen lyases || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || Hydro-lyases |
| Pyruvate oxidase and decarboxylase PP module | 0.00207 | INHERITED FROM: Pyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.01169 | INHERITED FROM: Carbon-oxygen lyases || Enoyl-CoA hydratase || Hydro-lyases |
| Shikimate dehydrogenase-like | 0.02273 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates || Carbon-oxygen lyases || Hydro-lyases |
| MAPEG domain | 0.02572 | INHERITED FROM: Carbon-sulfur lyases || Leukotriene-C(4) synthase |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0368 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || Carbon-carbon lyases |
| FabD-like | 0.04156 | INHERITED FROM: Carbon-oxygen lyases || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || Hydro-lyases |
| Phosphate binding protein-like | 0.06758 | INHERITED FROM: Peptidoglycan lytic exotransglycosylase || Acting on polysaccharides || Carbon-oxygen lyases || Arogenate dehydratase || Prephenate dehydratase |
| Terpene synthases | 0.1203 | INHERITED FROM: Squalene--hopanol cyclase || Hydro-lyases |
| Pyruvate oxidase and decarboxylase Pyr module | 0.2098 | INHERITED FROM: Pyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| Cytidylytransferase | 0.2413 | INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synth || Phosphorus-oxygen lyases |
| CBS-domain pair | 0.2489 | INHERITED FROM: Cystathionine beta-synthase |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.749 | INHERITED FROM: 2-oxoglutarate decarboxylase || Carboxy-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.7813 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| CAT-like | 0.8544 | INHERITED FROM: 2-oxoglutarate decarboxylase || Carboxy-lyases |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0.9282 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Glutamine synthetase, N-terminal domain | 0.9333 | INHERITED FROM: Carboxy-lyases || Glutamate decarboxylase |
| Glutamine synthetase catalytic domain | 0.9713 | INHERITED FROM: Carboxy-lyases || Glutamate decarboxylase |
| Glutathione S-transferase (GST), N-terminal domain | 1 | INHERITED FROM: Carbon-halide lyases |
| Enolpyruvate transferase, EPT | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || UDP-glucuronate decarboxylase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Glutathione S-transferase (GST), C-terminal domain | 1 | INHERITED FROM: Carbon-halide lyases |
| Thiolase-related | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Protein kinases, catalytic subunit | 1 | INHERITED FROM: Phosphorus-oxygen lyases || Guanylate cyclase |
| BC N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| GHMP Kinase, N-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| Enolase-phosphatase E1 | 1 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase |
| AAT-like | 1 | INHERITED FROM: Threonine-phosphate decarboxylase || Carbon-sulfur lyases || Cysteine-S-conjugate beta-lyase || Low-specificity L-threonine aldolase |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Cytochrome P450 | 1 | INHERITED FROM: Hydroperoxide dehydratase |
| BC ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Class I glutamine amidotransferases (GAT) | 1 | INHERITED FROM: Anthranilate synthase || Oxo-acid-lyases || Indole-3-glycerol-phosphate synthase |
| SAICAR synthase | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| PP2C-like | 1 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | INHERITED FROM: Tartrate decarboxylase |
| FAD-linked reductases, N-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| GMC oxidoreductases | 1 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase |
| BC C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| GABA-aminotransferase-like | 1 | INHERITED FROM: Carbon-sulfur lyases || 1-aminocyclopropane-1-carboxylate synthase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Rhamnogalacturonase B, RhgB, middle domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| Chlorophyll a-b binding protein | 0 | Direct |
| FAH | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| Arginine decarboxylase | 0 | Direct |
| Dimeric chorismate mutase | 0 | Direct |
| Crotonase-like | 0 | Direct |
| C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | Direct |
| Cyanase N-terminal domain | 0 | Direct |
| Uroporphyrinogen decarboxylase, UROD | 0 | Direct |
| HAL/PAL-like | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| Decarboxylase | 0 | Direct |
| IpsF-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| MaoC-like | 0 | Direct |
| ADC synthase | 0 | Direct |
| lvD/EDD N-terminal domain-like | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| Urocanase | 0 | Direct |
| HpcH/HpaI aldolase | 0 | Direct |
| IlvD/EDD C-terminal domain-like | 0 | Direct |
| Middle domain of MutM-like DNA repair proteins | 0 | Direct |
| Chorismate lyase | 0 | Direct |
| Alpha-acetolactate decarboxylase-like | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| Glyoxalase I (lactoylglutathione lyase) | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| Terpenoid cyclase C-terminal domain | 0 | Direct |
| Mevalonate 5-diphosphate decarboxylase | 0 | Direct |
| Beta-eliminating lyases | 0 | Direct |
| Allosteric threonine deaminase C-terminal domain | 0 | Direct |
| Ornithine decarboxylase major domain | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| Bacterial muramidase, catalytic domain | 0 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
| UxuA-like | 0 | Direct |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | Direct |
| Bacterial PLC | 0 | Direct |
| Endonuclease III | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| MerB N-terminal domain-like | 0 | Direct |
| Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | Direct |
| DHN aldolase/epimerase | 0 | Direct |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | Direct |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| Dehydroquinate synthase, DHQS | 0 | Direct |
| Methylglyoxal synthase, MgsA | 0 | Direct |
| Autoinducer-2 production protein LuxS | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| HMGL-like | 0 | Direct |
| Enolase | 0 | Direct |
| Siroheme synthase N-terminal domain-like | 0 | Direct |
| Histidine decarboxylase | 0 | Direct |
| Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | Direct |
| Terpenoid cyclase N-terminal domain | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| DmpG/LeuA communication domain-like | 0 | Direct |
| 6-pyruvoyl tetrahydropterin synthase | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| LeuD-like | 0 | Direct |
| Bacterial S-adenosylmethionine decarboxylase | 0 | Direct |
| CbiX-like | 0 | Direct |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | Direct |
| PCD-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Pectin lyase | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| Aristolochene/pentalenene synthase | 0 | Direct |
| L-arabinose binding protein-like | 0 | Direct |
| Alginate lyase A1-III | 0 | Direct |
| mono-SIS domain | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| AgoG-like | 0 | Direct |
| Tryptophan biosynthesis enzymes | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| RibA-like | 0 | Direct |
| MerB-like | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| H-NOX domain | 0 | Direct |
| Formaldehyde-activating enzyme, FAE | 0 | Direct |
| Trichodiene synthase | 0 | Direct |
| Phosphoenolpyruvate carboxylase | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| Pectate lyase-like | 0 | Direct |
| DJ-1/PfpI | 0 | Direct |
| YjeF C-terminal domain-like | 0 | Direct |
| Ferrochelatase | 0 | Direct |
| Hyaluronate lyase-like catalytic, N-terminal domain | 0 | Direct |
| HemD-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| RuBisCo, large subunit, C-terminal domain | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Hyaluronate lyase-like, central domain | 0 | Direct |
| Glutathione-dependent formaldehyde-activating enzyme, Gfa | 0 | Direct |
| Class I aldolase | 0 | Direct |
| Serine dehydratase beta chain-like | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| Imidazole glycerol phosphate dehydratase | 0 | Direct |
| Class II FBP aldolase | 0 | Direct |
| D-glucarate dehydratase-like | 0 | Direct |
| Hypothetical protein VC1974 | 0 | Direct |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| PP1699/LP2961-like | 0 | Direct |
| UraD-like | 0.000000000002503 | Direct |
| Pyruvate oxidase and decarboxylase, middle domain | 0.00000000000514 | Direct |
| CoaB-like | 0.0000000003957 | Direct |
| Nitrile hydratase beta chain | 0.000000002064 | Direct |
| Nitrile hydratase alpha chain | 0.000000002064 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000007824 | Direct |
| DNase I-like | 0.0000000344 | Direct |
| Phenylalanine metabolism regulatory domain | 0.00000005526 | Direct |
| NHL repeat | 0.0000001813 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000001813 | Direct |
| Ornithine cyclodeaminase-like | 0.0000009382 | Direct |
| Acyl-carrier protein (ACP) | 0.000001696 | Direct |
| DNA repair glycosylase, N-terminal domain | 0.00003793 | Direct |
| Cystathionine synthase-like | 0.00005429 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0.00005788 | Direct |
| DNA repair glycosylase, 2 C-terminal domains | 0.0001623 | Direct |
| MIF-related | 0.0001658 | Direct |
| Shikimate kinase (AroK) | 0.0001741 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.001397 | Inherited |
| Pyruvate oxidase and decarboxylase PP module | 0.00207 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.01169 | Inherited |
| Shikimate dehydrogenase-like | 0.02273 | Inherited |
| MAPEG domain | 0.02572 | Inherited |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0368 | Inherited |
| FabD-like | 0.04156 | Inherited |
| Phosphate binding protein-like | 0.06758 | Inherited |
| Terpene synthases | 0.1203 | Inherited |
| Pyruvate oxidase and decarboxylase Pyr module | 0.2098 | Inherited |
| Cytidylytransferase | 0.2413 | Inherited |
| CBS-domain pair | 0.2489 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.749 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.7813 | Inherited |
| CAT-like | 0.8544 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0.9282 | Inherited |
| Glutamine synthetase, N-terminal domain | 0.9333 | Inherited |
| Glutamine synthetase catalytic domain | 0.9713 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 1 | Inherited |
| Enolpyruvate transferase, EPT | 1 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 1 | Inherited |
| Thiolase-related | 1 | Inherited |
| Protein kinases, catalytic subunit | 1 | Inherited |
| BC N-terminal domain-like | 1 | Inherited |
| GHMP Kinase, N-terminal domain | 1 | Inherited |
| Enolase-phosphatase E1 | 1 | Inherited |
| AAT-like | 1 | Inherited |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| BC ATP-binding domain-like | 1 | Inherited |
| Class I glutamine amidotransferases (GAT) | 1 | Inherited |
| SAICAR synthase | 1 | Inherited |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | Inherited |
| PP2C-like | 1 | Inherited |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | Inherited |
| FAD-linked reductases, N-terminal domain | 1 | Inherited |
| GMC oxidoreductases | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
| BC C-terminal domain-like | 1 | Inherited |
| GABA-aminotransferase-like | 1 | Inherited |
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| IpsF-like | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| NosL/MerB-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| Chondroitin AC/alginate lyase | 0 | DIRECT |
| Chlorophyll a-b binding protein | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Periplasmic binding protein-like I | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| IlvD/EDD N-terminal domain-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| Lysozyme-like | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| FAH | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Chelatase | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| Adenylylcyclase toxin (the edema factor) | 0 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | DIRECT |
| UraD-Like | 0.00000000000131 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0.0000000000152 | DIRECT |
| CoaB-like | 0.0000000002016 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000001281 | DIRECT |
| SIS domain | 0.000000001982 | DIRECT |
| ClpP/crotonase | 0.0000000024 | DIRECT |
| Methylglyoxal synthase-like | 0.00000000302 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000003188 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000001258 | DIRECT |
| NHL repeat | 0.0000001258 | DIRECT |
| Electron transport accessory proteins | 0.0000005968 | DIRECT |
| Chorismate mutase II | 0.000001002 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.000002676 | DIRECT |
| Serine metabolism enzymes domain | 0.0000213 | DIRECT |
| TATA-box binding protein-like | 0.00002815 | DIRECT |
| Periplasmic binding protein-like II | 0.00006655 | DIRECT |
| PHM/PNGase F | 0.00007181 | DIRECT |
| Tautomerase/MIF | 0.0001696 | DIRECT |
| ACT-like | 0.0002997 | DIRECT |
| DHS-like NAD/FAD-binding domain | 0.002721 | INHERITED FROM: Pyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| Barwin-like endoglucanases | 0.003167 | INHERITED FROM: Peptidoglycan lytic exotransglycosylase || Acting on polysaccharides || Carbon-oxygen lyases |
| Calcium-dependent phosphotriesterase | 0.003776 | INHERITED FROM: Carbon-nitrogen lyases || Amine-lyases || Peptidylamidoglycolate lyase |
| DAK1/DegV-like | 0.004961 | INHERITED FROM: Phosphorus-oxygen lyases || FAD-AMP lyase (cyclizing) |
| DhaL-like | 0.004961 | INHERITED FROM: Phosphorus-oxygen lyases || FAD-AMP lyase (cyclizing) |
| Starch-binding domain-like | 0.01399 | INHERITED FROM: Acting on polysaccharides || Carbon-oxygen lyases || Rhamnogalacturonan endolyase |
| SCP-like | 0.01462 | INHERITED FROM: Enoyl-CoA hydratase 2 || Hydro-lyases || hydratase |
| MAPEG domain-like | 0.02046 | INHERITED FROM: Carbon-sulfur lyases || Leukotriene-C(4) synthase |
| Mss4-like | 0.02254 | INHERITED FROM: Carbon-sulfur lyases || S-(hydroxymethyl)glutathione synthase |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.02878 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || Carbon-carbon lyases |
| Ran binding protein zinc finger-like | 0.03863 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.05341 | INHERITED FROM: Carbon-oxygen lyases || Enoyl-CoA hydratase || Hydro-lyases |
| DNase I-like | 0.1794 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Carbon-oxygen lyases || Other carbon-oxygen lyases |
| CBS-domain pair | 0.2299 | INHERITED FROM: Cystathionine beta-synthase |
| Galactose mutarotase-like | 0.3497 | INHERITED FROM: Acting on polysaccharides || Hyaluronate lyase || Rhamnogalacturonan endolyase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.3583 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| SMAD/FHA domain | 0.361 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| RmlC-like cupins | 0.4961 | INHERITED FROM: Peptidyl-glutamate 4-carboxylase || Ectoine synthase || Hydro-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.5705 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| RNI-like | 0.5985 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| UBA-like | 0.7312 | INHERITED FROM: N-acetylmuramic acid 6-phosphate etherase |
| NTF2-like | 0.8605 | INHERITED FROM: Scytalone dehydratase |
| Glutamine synthetase, N-terminal domain | 0.8901 | INHERITED FROM: Carboxy-lyases || Glutamate decarboxylase |
| Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydroneopterin aldolase |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| TPR-like | 1 | INHERITED FROM: Adenylate cyclase |
| PP2C-like | 1 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || 3-dehydroquinate dehydratase || Other lyases || 3-dehydroquinate synthase || Sirohydrochlorin ferrochelatase || GDP-mannose 4,6-dehydratase || UDP-glucuronate decarboxylase || Enoyl-CoA hydratase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || hydratase || Ornithine cyclodeaminase |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Oleate hydratase || (R)-mandelonitrile lyase |
| GroES-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Citrate (pro-3S)-lyase |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synth || Phosphorus-oxygen lyases |
| Thioredoxin-like | 1 | INHERITED FROM: Carbon-halide lyases |
| ACP-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Cytochrome P450 | 1 | INHERITED FROM: Colneleate synthase || Hydroperoxide dehydratase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| L domain-like | 1 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase || Pyruvate decarboxylase || Sulfopyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| Single hybrid motif | 1 | INHERITED FROM: Oxaloacetate decarboxylase |
| HAD-like | 1 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase || Imidazoleglycerol-phosphate dehydratase || Hydro-lyases |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: Phosphorus-oxygen lyases || Guanylate cyclase |
| PLC-like phosphodiesterases | 1 | INHERITED FROM: Phosphatidylinositol diacylglycerol-lyase || Phosphorus-oxygen lyases |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Glutamine synthetase/guanido kinase | 1 | INHERITED FROM: Glutamate decarboxylase |
| EPT/RTPC-like | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
| PLP-dependent transferases | 1 | INHERITED FROM: Threonine-phosphate decarboxylase || Selenocysteine lyase || Tyrosine decarboxylase || Other carbon-carbon lyases || Lysine decarboxylase || Diaminobutyrate decarboxylase || Tryptophanase || Cystathionine beta-lyase || Histidine decarboxylase || Carbon-sulfur lyases || Cysteine-S-conjugate beta-lyase || Tyrosine phenol-lyase || Sulfinoalanine decarboxylase || Carbon-carbon lyases || Sphinganine-1-phosphate aldolase || 1-aminocyclopropane-1-carboxylate synthase || Glutamate decarboxylase || Cystathionine gamma-lyase || Low-specificity L-threonine aldolase || Aromatic-L-amino-acid decarboxylase |
| PFL-like glycyl radical enzymes | 1 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Other carbon-oxygen lyases || 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxyl || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Ribokinase-like | 1 | INHERITED FROM: ATP-dependent NAD(P)H-hydrate dehydratase || Hydro-lyases |
| Acylphosphatase/BLUF domain-like | 1 | INHERITED FROM: Adenylate cyclase |
| FabD/lysophospholipase-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Galactose-binding domain-like | 1 | INHERITED FROM: Acting on polysaccharides || Rhamnogalacturonan endolyase |
| GST C-terminal domain-like | 1 | INHERITED FROM: Carbon-halide lyases |
| Thiolase-like | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: D-lactate dehydratase || Anthranilate synthase || Oxo-acid-lyases || Indole-3-glycerol-phosphate synthase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || 6-pyruvoyltetrahydropterin synthase |
| "Winged helix" DNA-binding domain | 1 | INHERITED FROM: Alkylmercury lyase |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| CheY-like | 1 | INHERITED FROM: Ornithine decarboxylase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| IpsF-like | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| NosL/MerB-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| ADC-like | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| Aldolase | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| HemD-like | 0 | Direct |
| S13-like H2TH domain | 0 | Direct |
| Chondroitin AC/alginate lyase | 0 | Direct |
| Chlorophyll a-b binding protein | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Periplasmic binding protein-like I | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| IlvD/EDD N-terminal domain-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Bacterial muramidases | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| Lysozyme-like | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| Pectin lyase-like | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| Urocanase | 0 | Direct |
| FAH | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| PCD-like | 0 | Direct |
| Chelatase | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| RibA-like | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| Adenylylcyclase toxin (the edema factor) | 0 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
| ADC synthase | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | Direct |
| UraD-Like | 0.00000000000131 | Direct |
| AF0104/ALDC/Ptd012-like | 0.0000000000152 | Direct |
| CoaB-like | 0.0000000002016 | Direct |
| Nitrile hydratase alpha chain | 0.000000001281 | Direct |
| SIS domain | 0.000000001982 | Direct |
| ClpP/crotonase | 0.0000000024 | Direct |
| Methylglyoxal synthase-like | 0.00000000302 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000003188 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000001258 | Direct |
| NHL repeat | 0.0000001258 | Direct |
| Electron transport accessory proteins | 0.0000005968 | Direct |
| Chorismate mutase II | 0.000001002 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.000002676 | Direct |
| Serine metabolism enzymes domain | 0.0000213 | Direct |
| TATA-box binding protein-like | 0.00002815 | Direct |
| Periplasmic binding protein-like II | 0.00006655 | Direct |
| PHM/PNGase F | 0.00007181 | Direct |
| Tautomerase/MIF | 0.0001696 | Direct |
| ACT-like | 0.0002997 | Direct |
| DHS-like NAD/FAD-binding domain | 0.002721 | Inherited |
| Barwin-like endoglucanases | 0.003167 | Inherited |
| Calcium-dependent phosphotriesterase | 0.003776 | Inherited |
| DAK1/DegV-like | 0.004961 | Inherited |
| DhaL-like | 0.004961 | Inherited |
| Starch-binding domain-like | 0.01399 | Inherited |
| SCP-like | 0.01462 | Inherited |
| MAPEG domain-like | 0.02046 | Inherited |
| Mss4-like | 0.02254 | Inherited |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.02878 | Inherited |
| Ran binding protein zinc finger-like | 0.03863 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.05341 | Inherited |
| DNase I-like | 0.1794 | Inherited |
| CBS-domain pair | 0.2299 | Inherited |
| Galactose mutarotase-like | 0.3497 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.3583 | Inherited |
| SMAD/FHA domain | 0.361 | Inherited |
| RmlC-like cupins | 0.4961 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.5705 | Inherited |
| RNI-like | 0.5985 | Inherited |
| UBA-like | 0.7312 | Inherited |
| NTF2-like | 0.8605 | Inherited |
| Glutamine synthetase, N-terminal domain | 0.8901 | Inherited |
| Dihydropteroate synthetase-like | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| TPR-like | 1 | Inherited |
| PP2C-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| GroES-like | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| ACP-like | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| L domain-like | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| Rudiment single hybrid motif | 1 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
| Single hybrid motif | 1 | Inherited |
| HAD-like | 1 | Inherited |
| Protein kinase-like (PK-like) | 1 | Inherited |
| PLC-like phosphodiesterases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Glutamine synthetase/guanido kinase | 1 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| PFL-like glycyl radical enzymes | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| Ribokinase-like | 1 | Inherited |
| Acylphosphatase/BLUF domain-like | 1 | Inherited |
| FabD/lysophospholipase-like | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| Galactose-binding domain-like | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
| "Winged helix" DNA-binding domain | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| CheY-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | DIRECT |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48230,74650
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
49452,49785
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
53850,53955
53850 - Periplasmic binding protein-like II
53955 - Lysozyme-like | 0 | DIRECT |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | DIRECT |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | DIRECT |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | DIRECT |
53448,69765
53448 - Nucleotide-diphospho-sugar transferases
69765 - IpsF-like | 0 | DIRECT |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | DIRECT |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | DIRECT |
48557,55729
48557 - L-aspartase-like
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
74650,49863
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | DIRECT |
56529,56529
56529 - FAH
56529 - FAH | 0 | DIRECT |
46785,160387
46785 - "Winged helix" DNA-binding domain
160387 - NosL/MerB-like | 0 | DIRECT |
46946,57716
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
81624,46946
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain | 0 | DIRECT |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | DIRECT |
54975,55073
54975 - Acylphosphatase/BLUF domain-like
55073 - Nucleotide cyclase | 0 | DIRECT |
55073,52540
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | DIRECT |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
53686,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like | 0 | DIRECT |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | DIRECT |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | DIRECT |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
81606,55073
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | DIRECT |
53822,56112
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48435,53955
48435 - Bacterial muramidases
53955 - Lysozyme-like | 0 | DIRECT |
74650,49452
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like | 0 | DIRECT |
53800,103511
53800 - Chelatase
103511 - Chlorophyll a-b binding protein | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
55073,55073
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase | 0 | DIRECT |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0.00000000000005006 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0.000004441 | DIRECT |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.000004708 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000007816 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000008419 | DIRECT |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0.00001147 | DIRECT |
55945,48150
55945 - TATA-box binding protein-like
48150 - DNA-glycosylase | 0.00002815 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.00007181 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001208 | DIRECT |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.0001732 | DIRECT |
52058,81606
52058 - L domain-like
81606 - PP2C-like | 0.0005447 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0009867 | DIRECT |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.003167 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || Carbon-carbon lyases |
82549,101473
82549 - DAK1/DegV-like
101473 - DhaL-like | 0.004961 | INHERITED FROM: Phosphorus-oxygen lyases || FAD-AMP lyase (cyclizing) |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.02046 | INHERITED FROM: Carbon-oxygen lyases || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || Hydro-lyases |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.05249 | INHERITED FROM: Carbon-oxygen lyases || Enoyl-CoA hydratase || Hydro-lyases |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.09487 | INHERITED FROM: Oxo-acid-lyases || Citrate (pro-3S)-lyase || Carbon-carbon lyases |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.1046 | INHERITED FROM: Dihydroneopterin aldolase || Carbon-carbon lyases |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.3583 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
54368,55931
54368 - Glutamine synthetase, N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0.8901 | INHERITED FROM: Carboxy-lyases || Glutamate decarboxylase |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | INHERITED FROM: Carbon-halide lyases |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | INHERITED FROM: Threonine ammonia-lyase || Ammonia-lyases || Carbon-nitrogen lyases |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | Direct |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48230,74650
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
49452,49785
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
53850,53955
53850 - Periplasmic binding protein-like II
53955 - Lysozyme-like | 0 | Direct |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | Direct |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | Direct |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | Direct |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | Direct |
53448,69765
53448 - Nucleotide-diphospho-sugar transferases
69765 - IpsF-like | 0 | Direct |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | Direct |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | Direct |
48557,55729
48557 - L-aspartase-like
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
74650,49863
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | Direct |
56529,56529
56529 - FAH
56529 - FAH | 0 | Direct |
46785,160387
46785 - "Winged helix" DNA-binding domain
160387 - NosL/MerB-like | 0 | Direct |
46946,57716
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
81624,46946
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain | 0 | Direct |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | Direct |
54975,55073
54975 - Acylphosphatase/BLUF domain-like
55073 - Nucleotide cyclase | 0 | Direct |
55073,52540
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | Direct |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | Direct |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
53686,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like | 0 | Direct |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | Direct |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | Direct |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
81606,55073
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | Direct |
53822,56112
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48435,53955
48435 - Bacterial muramidases
53955 - Lysozyme-like | 0 | Direct |
74650,49452
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like | 0 | Direct |
53800,103511
53800 - Chelatase
103511 - Chlorophyll a-b binding protein | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | Direct |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
55073,55073
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase | 0 | Direct |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0.00000000000005006 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0.000004441 | Direct |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.000004708 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000007816 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000008419 | Direct |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0.00001147 | Direct |
55945,48150
55945 - TATA-box binding protein-like
48150 - DNA-glycosylase | 0.00002815 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.00007181 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001208 | Direct |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.0001732 | Direct |
52058,81606
52058 - L domain-like
81606 - PP2C-like | 0.0005447 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0009867 | Direct |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.003167 | Inherited |
82549,101473
82549 - DAK1/DegV-like
101473 - DhaL-like | 0.004961 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.02046 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.05249 | Inherited |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.09487 | Inherited |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.1046 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.3583 | Inherited |
54368,55931
54368 - Glutamine synthetase, N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0.8901 | Inherited |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | Inherited |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | Inherited |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | Inherited |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | Inherited |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53822,56112,55073
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | DIRECT |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
55116,55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | DIRECT |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | DIRECT |
53686,55021,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like
55021 - ACT-like | 0 | DIRECT |
74650,49452,49785
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
81624,46946,57716
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
55073,55073,52540
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
52058,81606,55073
52058 - L domain-like
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | DIRECT |
48230,74650,49863
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000001245 | DIRECT |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.00001009 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001208 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0006287 | DIRECT |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0127 | INHERITED FROM: Carbon-oxygen lyases || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || Hydro-lyases |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53822,56112,55073
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | Direct |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
55116,55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | Direct |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | Direct |
53686,55021,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like
55021 - ACT-like | 0 | Direct |
74650,49452,49785
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
81624,46946,57716
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
55073,55073,52540
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
52058,81606,55073
52058 - L domain-like
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | Direct |
48230,74650,49863
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000001245 | Direct |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.00001009 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001208 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0006287 | Direct |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0127 | Inherited |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
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