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Carbon-carbon lyases
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| PLP-binding barrel | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| UraD-Like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| DHS-like NAD/FAD-binding domain | 9.368e-16 | DIRECT |
| PLP-dependent transferases | 0.0000000001997 | DIRECT |
| Tautomerase/MIF | 0.00000001825 | DIRECT |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.00005088 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.0002189 | DIRECT |
| Glutamine synthetase, N-terminal domain | 0.003964 | INHERITED FROM: Glutamate decarboxylase || Carboxy-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.007714 | INHERITED FROM: Aminodeoxychorismate lyase || Oxo-acid-lyases |
| Rudiment single hybrid motif | 0.04966 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.05614 | INHERITED FROM: Dihydroneopterin aldolase || Aldehyde-lyases |
| CoA-dependent acyltransferases | 0.1082 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Class I glutamine amidotransferase-like | 0.3431 | INHERITED FROM: Indole-3-glycerol-phosphate synthase || Anthranilate synthase || Oxo-acid-lyases |
| Glutamine synthetase/guanido kinase | 0.4168 | INHERITED FROM: Glutamate decarboxylase |
| FAH | 1 | INHERITED FROM: Carboxy-lyases |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| ClpP/crotonase | 1 | INHERITED FROM: 1,4-dihydroxy-2-naphthoyl-CoA synthase || Methylmalonyl-CoA decarboxylase || Oxo-acid-lyases || Ethylmalonyl-CoA decarboxylase |
| AraD/HMP-PK domain-like | 1 | INHERITED FROM: L-fuculose-phosphate aldolase || Rhamnulose-1-phosphate aldolase || Aldehyde-lyases |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| RmlC-like cupins | 1 | INHERITED FROM: Peptidyl-glutamate 4-carboxylase |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase || 3-hexulose-6-phosphate synthase |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: UDP-glucuronate decarboxylase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| PLP-binding barrel | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Aldolase | 0 | Direct |
| AF0104/ALDC/Ptd012-like | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| RibA-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| UraD-Like | 0 | Direct |
| ADC-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| CoaB-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| ADC synthase | 0 | Direct |
| DHS-like NAD/FAD-binding domain | 9.368e-16 | Direct |
| PLP-dependent transferases | 0.0000000001997 | Direct |
| Tautomerase/MIF | 0.00000001825 | Direct |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.00005088 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.0002189 | Direct |
| Glutamine synthetase, N-terminal domain | 0.003964 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.007714 | Inherited |
| Rudiment single hybrid motif | 0.04966 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.05614 | Inherited |
| CoA-dependent acyltransferases | 0.1082 | Inherited |
| Class I glutamine amidotransferase-like | 0.3431 | Inherited |
| Glutamine synthetase/guanido kinase | 0.4168 | Inherited |
| FAH | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| AraD/HMP-PK domain-like | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| RmlC-like cupins | 1 | Inherited |
| Ribosomal protein S5 domain 2-like | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| Arginine decarboxylase | 0 | DIRECT |
| Pyruvate oxidase and decarboxylase PP module | 0 | DIRECT |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | DIRECT |
| Uroporphyrinogen decarboxylase, UROD | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| Decarboxylase | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| HpcH/HpaI aldolase | 0 | DIRECT |
| Chorismate lyase | 0 | DIRECT |
| Alpha-acetolactate decarboxylase-like | 0 | DIRECT |
| Mevalonate 5-diphosphate decarboxylase | 0 | DIRECT |
| Beta-eliminating lyases | 0 | DIRECT |
| Ornithine decarboxylase major domain | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| DHN aldolase/epimerase | 0 | DIRECT |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | DIRECT |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| HMGL-like | 0 | DIRECT |
| Histidine decarboxylase | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| DmpG/LeuA communication domain-like | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| Bacterial S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| Formaldehyde-activating enzyme, FAE | 0 | DIRECT |
| Phosphoenolpyruvate carboxylase | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
| UraD-like | 0 | DIRECT |
| RuBisCo, large subunit, C-terminal domain | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Class II FBP aldolase | 0 | DIRECT |
| Pyruvate oxidase and decarboxylase, middle domain | 0 | DIRECT |
| PP1699/LP2961-like | 0 | DIRECT |
| CoaB-like | 1.746e-16 | DIRECT |
| Tryptophan biosynthesis enzymes | 0.000000000001624 | DIRECT |
| Pyruvate oxidase and decarboxylase Pyr module | 0.00000000003283 | DIRECT |
| Class I aldolase | 0.000000005623 | DIRECT |
| MIF-related | 0.00000001371 | DIRECT |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.00005763 | DIRECT |
| Glutamine synthetase, N-terminal domain | 0.004793 | INHERITED FROM: Glutamate decarboxylase || Carboxy-lyases |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.005583 | INHERITED FROM: 2-oxoglutarate decarboxylase || Carboxy-lyases |
| CAT-like | 0.006406 | INHERITED FROM: 2-oxoglutarate decarboxylase || Carboxy-lyases |
| Glutamine synthetase catalytic domain | 0.006882 | INHERITED FROM: Glutamate decarboxylase || Carboxy-lyases |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0.01627 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.02756 | INHERITED FROM: Aminodeoxychorismate lyase || Oxo-acid-lyases |
| BC C-terminal domain-like | 0.05958 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| GMC oxidoreductases | 0.09426 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| Class I glutamine amidotransferases (GAT) | 0.1627 | INHERITED FROM: Indole-3-glycerol-phosphate synthase || Anthranilate synthase || Oxo-acid-lyases |
| BC ATP-binding domain-like | 0.8884 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| BC N-terminal domain-like | 0.9427 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: UDP-glucuronate decarboxylase |
| FAH | 1 | INHERITED FROM: Carboxy-lyases |
| Crotonase-like | 1 | INHERITED FROM: 1,4-dihydroxy-2-naphthoyl-CoA synthase || Methylmalonyl-CoA decarboxylase || Oxo-acid-lyases || Ethylmalonyl-CoA decarboxylase |
| GHMP Kinase, N-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| AAT-like | 1 | INHERITED FROM: Threonine-phosphate decarboxylase || Low-specificity L-threonine aldolase |
| SAICAR synthase | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | INHERITED FROM: Tartrate decarboxylase |
| FAD-linked reductases, N-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| AraD-like aldolase/epimerase | 1 | INHERITED FROM: L-fuculose-phosphate aldolase || Rhamnulose-1-phosphate aldolase || Aldehyde-lyases |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| Arginine decarboxylase | 0 | Direct |
| Pyruvate oxidase and decarboxylase PP module | 0 | Direct |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | Direct |
| Uroporphyrinogen decarboxylase, UROD | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| Decarboxylase | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| ADC synthase | 0 | Direct |
| HpcH/HpaI aldolase | 0 | Direct |
| Chorismate lyase | 0 | Direct |
| Alpha-acetolactate decarboxylase-like | 0 | Direct |
| Mevalonate 5-diphosphate decarboxylase | 0 | Direct |
| Beta-eliminating lyases | 0 | Direct |
| Ornithine decarboxylase major domain | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| DHN aldolase/epimerase | 0 | Direct |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | Direct |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| HMGL-like | 0 | Direct |
| Histidine decarboxylase | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| DmpG/LeuA communication domain-like | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| Bacterial S-adenosylmethionine decarboxylase | 0 | Direct |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| RibA-like | 0 | Direct |
| Formaldehyde-activating enzyme, FAE | 0 | Direct |
| Phosphoenolpyruvate carboxylase | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
| UraD-like | 0 | Direct |
| RuBisCo, large subunit, C-terminal domain | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Class II FBP aldolase | 0 | Direct |
| Pyruvate oxidase and decarboxylase, middle domain | 0 | Direct |
| PP1699/LP2961-like | 0 | Direct |
| CoaB-like | 1.746e-16 | Direct |
| Tryptophan biosynthesis enzymes | 0.000000000001624 | Direct |
| Pyruvate oxidase and decarboxylase Pyr module | 0.00000000003283 | Direct |
| Class I aldolase | 0.000000005623 | Direct |
| MIF-related | 0.00000001371 | Direct |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.00005763 | Direct |
| Glutamine synthetase, N-terminal domain | 0.004793 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.005583 | Inherited |
| CAT-like | 0.006406 | Inherited |
| Glutamine synthetase catalytic domain | 0.006882 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0.01627 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.02756 | Inherited |
| BC C-terminal domain-like | 0.05958 | Inherited |
| GMC oxidoreductases | 0.09426 | Inherited |
| Class I glutamine amidotransferases (GAT) | 0.1627 | Inherited |
| BC ATP-binding domain-like | 0.8884 | Inherited |
| BC N-terminal domain-like | 0.9427 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| FAH | 1 | Inherited |
| Crotonase-like | 1 | Inherited |
| GHMP Kinase, N-terminal domain | 1 | Inherited |
| AAT-like | 1 | Inherited |
| SAICAR synthase | 1 | Inherited |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | Inherited |
| FAD-linked reductases, N-terminal domain | 1 | Inherited |
| AraD-like aldolase/epimerase | 1 | Inherited |
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| UraD-Like | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| DHS-like NAD/FAD-binding domain | 6.987e-16 | DIRECT |
| PLP-dependent transferases | 0.000000000127 | DIRECT |
| Tautomerase/MIF | 0.00000001422 | DIRECT |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.00004161 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.0001749 | DIRECT |
| Glutamine synthetase, N-terminal domain | 0.003342 | INHERITED FROM: Glutamate decarboxylase || Carboxy-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.006599 | INHERITED FROM: Aminodeoxychorismate lyase || Oxo-acid-lyases |
| Rudiment single hybrid motif | 0.04332 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.04849 | INHERITED FROM: Dihydroneopterin aldolase || Aldehyde-lyases |
| CoA-dependent acyltransferases | 0.09599 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Class I glutamine amidotransferase-like | 0.3084 | INHERITED FROM: Indole-3-glycerol-phosphate synthase || Anthranilate synthase || Oxo-acid-lyases |
| PFL-like glycyl radical enzymes | 0.3322 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| Glutamine synthetase/guanido kinase | 0.3824 | INHERITED FROM: Glutamate decarboxylase |
| Single hybrid motif | 0.54 | INHERITED FROM: Oxaloacetate decarboxylase |
| Dihydropteroate synthetase-like | 0.9632 | INHERITED FROM: Dihydroneopterin aldolase |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: UDP-glucuronate decarboxylase |
| AraD/HMP-PK domain-like | 1 | INHERITED FROM: L-fuculose-phosphate aldolase || Rhamnulose-1-phosphate aldolase || Aldehyde-lyases |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Citrate (pro-3S)-lyase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| FAH | 1 | INHERITED FROM: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase || Carboxy-lyases || 4-oxalocrotonate decarboxylase |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| ClpP/crotonase | 1 | INHERITED FROM: 1,4-dihydroxy-2-naphthoyl-CoA synthase || Methylmalonyl-CoA decarboxylase || Oxo-acid-lyases || 4.1.1.94 |
| RmlC-like cupins | 1 | INHERITED FROM: Peptidyl-glutamate 4-carboxylase |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase || 3-hexulose-6-phosphate synthase |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| CheY-like | 1 | INHERITED FROM: Ornithine decarboxylase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| UraD-Like | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
| AF0104/ALDC/Ptd012-like | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| ADC-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| Aldolase | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| RibA-like | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| CoaB-like | 0 | Direct |
| ADC synthase | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| DHS-like NAD/FAD-binding domain | 6.987e-16 | Direct |
| PLP-dependent transferases | 0.000000000127 | Direct |
| Tautomerase/MIF | 0.00000001422 | Direct |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.00004161 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.0001749 | Direct |
| Glutamine synthetase, N-terminal domain | 0.003342 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.006599 | Inherited |
| Rudiment single hybrid motif | 0.04332 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.04849 | Inherited |
| CoA-dependent acyltransferases | 0.09599 | Inherited |
| Class I glutamine amidotransferase-like | 0.3084 | Inherited |
| PFL-like glycyl radical enzymes | 0.3322 | Inherited |
| Glutamine synthetase/guanido kinase | 0.3824 | Inherited |
| Single hybrid motif | 0.54 | Inherited |
| Dihydropteroate synthetase-like | 0.9632 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| AraD/HMP-PK domain-like | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| FAH | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| RmlC-like cupins | 1 | Inherited |
| Ribosomal protein S5 domain 2-like | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| CheY-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | DIRECT |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | DIRECT |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | DIRECT |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | DIRECT |
56529,56529
56529 - FAH
56529 - FAH | 0 | DIRECT |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | DIRECT |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0 | DIRECT |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.00004046 | DIRECT |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.0005338 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.0009703 | DIRECT |
54368,55931
54368 - Glutamine synthetase, N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0.003342 | INHERITED FROM: Glutamate decarboxylase || Carboxy-lyases |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.04332 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.9626 | INHERITED FROM: 2-oxoglutarate decarboxylase |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | Direct |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | Direct |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | Direct |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | Direct |
56529,56529
56529 - FAH
56529 - FAH | 0 | Direct |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | Direct |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0 | Direct |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.00004046 | Direct |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.0005338 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.0009703 | Direct |
54368,55931
54368 - Glutamine synthetase, N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0.003342 | Inherited |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.04332 | Inherited |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.9626 | Inherited |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | Inherited |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | DIRECT |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.04204 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | Direct |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.04204 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
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