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Hydro-lyases
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
| Shortest distance to current term (+ for parents, - for children) |
EC term [EC ID] <#Children> |
(#SF|#FA) |
#Supra-domain (Single|Duplex|Triple) |
| + + + 3: | root [root] <6> |
| + + 2: | Lyases [4] <7> | (139|176) |
(158|94|34) |
| + 1: | Carbon-oxygen lyases [4.2] <4> | (68|83) |
(76|43|20) |
| 0: | Hydro-lyases [4.2.1] <132> | (51|57) |
(55|33|16) |
| - 1: | (R)-2-methylmalate dehydratase [4.2.1.35] | (0|0) |
(0|0|0) |
| - 1: | (S)-2-methylmalate dehydratase [4.2.1.34] | (0|0) |
(0|0|0) |
| - 1: | (S)-norcoclaurine synthase [4.2.1.78] | (0|0) |
(0|0|0) |
| - 1: | 1,5-anhydro-D-fructose dehydratase [4.2.1.111] | (0|0) |
(0|0|0) |
| - 1: | 16-alpha-hydroxyprogesterone dehydratase [4.2.1.98] | (0|0) |
(0|0|0) |
| - 1: | 2-dehydro-3-deoxy-L-arabinonate dehydratase [4.2.1.43] | (0|0) |
(0|0|0) |
| - 1: | 2-hydroxyisoflavanone dehydratase [4.2.1.105] | (0|0) |
(0|0|0) |
| - 1: | 2-methylcitrate dehydratase [4.2.1.79] | (1|1) |
(1|0|0) |
| - 1: | 2-methylcitrate dehydratase (2-methyl-trans-aconit [4.2.1.117] | (0|0) |
(0|0|0) |
| - 1: | 2-methylisocitrate dehydratase [4.2.1.99] | (3|3) |
(3|2|1) |
| - 1: | 2-oxopent-4-enoate hydratase [4.2.1.80] | (1|1) |
(1|0|0) |
| - 1: | 3-cyanoalanine hydratase [4.2.1.65] | (0|0) |
(0|0|0) |
| - 1: | 3-dehydroquinate dehydratase [4.2.1.10] | (6|7) |
(6|5|4) |
| - 1: | 3-dehydroshikimate dehydratase [4.2.1.118] | (0|0) |
(0|0|0) |
| - 1: | 3-hydroxybutyryl-CoA dehydratase [4.2.1.55] | (0|0) |
(0|0|0) |
| - 1: | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydrata [4.2.1.60] | (1|1) |
(1|0|0) |
| - 1: | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydrata [4.2.1.59] | (0|0) |
(0|0|0) |
| - 1: | 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat [4.2.1.61] | (9|8) |
(9|6|3) |
| - 1: | 3-hydroxypropionyl-CoA dehydratase [4.2.1.116] | (0|0) |
(0|0|0) |
| - 1: | 3-isopropylmalate dehydratase [4.2.1.33] | (2|2) |
(2|0|0) |
| - 1: | 4-hydroxybutanoyl-CoA dehydratase [4.2.1.120] | (0|0) |
(0|0|0) |
| - 1: | 4-oxalmesaconate hydratase [4.2.1.83] | (0|0) |
(0|0|0) |
| - 1: | 4a-hydroxytetrahydrobiopterin dehydratase [4.2.1.96] | (1|1) |
(1|0|0) |
| - 1: | 5-alpha-hydroxysteroid dehydratase [4.2.1.62] | (0|0) |
(0|0|0) |
| - 1: | 5-dehydro-4-deoxyglucarate dehydratase [4.2.1.41] | (1|1) |
(1|0|0) |
| - 1: | ATP-dependent NAD(P)H-hydrate dehydratase [4.2.1.93] | (1|1) |
(1|0|0) |
| - 1: | Acetylene hydratase [4.2.1.112] | (0|0) |
(0|0|0) |
| - 1: | Acetylenecarboxylate hydratase [4.2.1.27] | (0|0) |
(0|0|0) |
| - 1: | Aconitate hydratase [4.2.1.3] | (3|3) |
(3|3|1) |
| - 1: | Aldos-2-ulose dehydratase [4.2.1.110] | (0|0) |
(0|0|0) |
| - 1: | Altronate dehydratase [4.2.1.7] | (0|0) |
(0|0|0) |
| - 1: | Arabidiol synthase [4.2.1.124] | (0|0) |
(0|0|0) |
| - 1: | Arabinonate dehydratase [4.2.1.5] | (0|0) |
(0|0|0) |
| - 1: | Arogenate dehydratase [4.2.1.91] | (2|1) |
(2|1|0) |
| - 1: | Bile-acid 7-alpha-dehydratase [4.2.1.106] | (0|0) |
(0|0|0) |
| - 1: | CDP-glucose 4,6-dehydratase [4.2.1.45] | (0|0) |
(0|0|0) |
| - 1: | Carbonate dehydratase [4.2.1.1] | (2|2) |
(2|0|0) |
| - 1: | Carnitine dehydratase [4.2.1.89] | (0|0) |
(0|0|0) |
| - 1: | Carotenoid 1,2-hydratase [4.2.1.131] | (0|0) |
(0|0|0) |
| - 1: | Citrate dehydratase [4.2.1.4] | (0|0) |
(0|0|0) |
| - 1: | Colneleate synthase [4.2.1.121] | (0|0) |
(1|0|0) |
| - 1: | Crotonoyl-[acyl-carrier-protein] hydratase [4.2.1.58] | (0|0) |
(0|0|0) |
| - 1: | Cyanamide hydratase [4.2.1.69] | (0|0) |
(0|0|0) |
| - 1: | Cyanase [4.2.1.104] | (2|2) |
(2|1|0) |
| - 1: | Cyanide hydratase [4.2.1.66] | (0|0) |
(0|0|0) |
| - 1: | Cyclohexa-1,5-dienecarbonyl-CoA hydratase [4.2.1.100] | (0|0) |
(0|0|0) |
| - 1: | Cyclohexyl-isocyanide hydratase [4.2.1.103] | (0|0) |
(0|0|0) |
| - 1: | Cystathionine beta-synthase [4.2.1.22] | (2|2) |
(2|1|0) |
| - 1: | D(-)-tartrate dehydratase [4.2.1.81] | (0|0) |
(0|0|0) |
| - 1: | D-fuconate dehydratase [4.2.1.67] | (0|0) |
(0|0|0) |
| - 1: | D-glutamate cyclase [4.2.1.48] | (0|0) |
(0|0|0) |
| - 1: | D-lactate dehydratase [4.2.1.130] | (1|1) |
(1|0|0) |
| - 1: | Dammarenediol II synthase [4.2.1.125] | (0|0) |
(0|0|0) |
| - 1: | Deleted entry [4.2.1.23] | (0|0) |
(0|0|0) |
| - 1: | Dihydrodipicolinate synthase [4.2.1.52] | (1|1) |
(1|0|0) |
| - 1: | Dihydroxy-acid dehydratase [4.2.1.9] | (2|2) |
(2|1|0) |
| - 1: | Dimethylmaleate hydratase [4.2.1.85] | (0|0) |
(0|0|0) |
| - 1: | Ectoine synthase [4.2.1.108] | (1|0) |
(1|0|0) |
| - 1: | Enoyl-CoA hydratase [4.2.1.17] | (3|3) |
(3|4|3) |
| - 1: | Enoyl-CoA hydratase 2 [4.2.1.119] | (2|2) |
(3|4|3) |
| - 1: | Fumarate hydratase [4.2.1.2] | (2|2) |
(2|0|0) |
| - 1: | GDP-mannose 4,6-dehydratase [4.2.1.47] | (1|1) |
(1|0|0) |
| - 1: | Galactarate dehydratase [4.2.1.42] | (0|0) |
(0|0|0) |
| - 1: | Galactonate dehydratase [4.2.1.6] | (2|2) |
(2|1|0) |
| - 1: | Glucarate dehydratase [4.2.1.40] | (0|0) |
(2|1|0) |
| - 1: | Gluconate dehydratase [4.2.1.39] | (0|0) |
(0|0|0) |
| - 1: | Glycerol dehydratase [4.2.1.30] | (0|0) |
(0|0|0) |
| - 1: | Homoaconitate hydratase [4.2.1.36] | (2|2) |
(2|1|0) |
| - 1: | Hydroperoxide dehydratase [4.2.1.92] | (1|1) |
(1|0|0) |
| - 1: | Imidazoleglycerol-phosphate dehydratase [4.2.1.19] | (2|2) |
(2|2|1) |
| - 1: | Isohexenylglutaconyl-CoA hydratase [4.2.1.57] | (0|0) |
(0|0|0) |
| - 1: | Itaconyl-CoA hydratase [4.2.1.56] | (0|0) |
(0|0|0) |
| - 1: | Kievitone hydratase [4.2.1.95] | (0|0) |
(0|0|0) |
| - 1: | L(+)-tartrate dehydratase [4.2.1.32] | (0|0) |
(1|0|0) |
| - 1: | L-arabinonate dehydratase [4.2.1.25] | (0|0) |
(0|0|0) |
| - 1: | L-fuconate dehydratase [4.2.1.68] | (0|0) |
(0|0|0) |
| - 1: | L-rhamnonate dehydratase [4.2.1.90] | (2|2) |
(2|1|0) |
| - 1: | Lactoyl-CoA dehydratase [4.2.1.54] | (0|0) |
(0|0|0) |
| - 1: | Linalool dehydratase [4.2.1.127] | (0|0) |
(0|0|0) |
| - 1: | Long-chain-enoyl-CoA hydratase [4.2.1.74] | (0|0) |
(0|0|0) |
| - 1: | Lupan-3-beta,20-diol synthase [4.2.1.128] | (0|0) |
(0|0|0) |
| - 1: | Maleate hydratase [4.2.1.31] | (0|0) |
(0|0|0) |
| - 1: | Mannonate dehydratase [4.2.1.8] | (1|1) |
(1|0|0) |
| - 1: | Methanogen homoaconitase [4.2.1.114] | (0|0) |
(0|0|0) |
| - 1: | Methylglutaconyl-CoA hydratase [4.2.1.18] | (0|0) |
(1|0|0) |
| - 1: | Methylthioribulose 1-phosphate dehydratase [4.2.1.109] | (2|2) |
(2|1|0) |
| - 1: | Myo-inosose-2 dehydratase [4.2.1.44] | (1|0) |
(1|0|0) |
| - 1: | N-acetylmuramic acid 6-phosphate etherase [4.2.1.126] | (1|1) |
(2|1|0) |
| - 1: | Nitrile hydratase [4.2.1.84] | (2|2) |
(2|0|0) |
| - 1: | Octopamine dehydratase [4.2.1.87] | (0|0) |
(0|0|0) |
| - 1: | Oleate hydratase [4.2.1.53] | (0|0) |
(1|0|0) |
| - 1: | Phaseollidin hydratase [4.2.1.97] | (0|0) |
(0|0|0) |
| - 1: | Phosphogluconate dehydratase [4.2.1.12] | (2|2) |
(2|1|0) |
| - 1: | Phosphopyruvate hydratase [4.2.1.11] | (2|2) |
(2|1|0) |
| - 1: | Porphobilinogen synthase [4.2.1.24] | (1|1) |
(1|0|0) |
| - 1: | Prephenate dehydratase [4.2.1.51] | (3|3) |
(3|2|1) |
| - 1: | Propanediol dehydratase [4.2.1.28] | (0|0) |
(0|0|0) |
| - 1: | Protoaphin-aglucone dehydratase (cyclizing) [4.2.1.73] | (0|0) |
(0|0|0) |
| - 1: | Pseudouridylate synthase [4.2.1.70] | (0|0) |
(0|0|0) |
| - 1: | Pyrazolylalanine synthase [4.2.1.50] | (0|0) |
(0|0|0) |
| - 1: | Scytalone dehydratase [4.2.1.94] | (0|0) |
(1|0|0) |
| - 1: | Squalene--hopanol cyclase [4.2.1.129] | (1|1) |
(1|1|0) |
| - 1: | Synephrine dehydratase [4.2.1.88] | (0|0) |
(0|0|0) |
| - 1: | Tetrahymanol synthase [4.2.1.123] | (0|0) |
(0|0|0) |
| - 1: | Trans-L-3-hydroxyproline dehydratase [4.2.1.77] | (0|0) |
(0|0|0) |
| - 1: | Trans-feruloyl-CoA hydratase [4.2.1.101] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.3.2.4 [4.2.1.37] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.3.2.9 and 3.3.2.10 [4.2.1.63] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.3.2.9 and 3.3.2.10 [4.2.1.64] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.1.1.78 [4.2.1.72] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.2.1.100 [4.2.1.102] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.2.1.126 [4.2.1.n1] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.2.1.22 [4.2.1.21] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.2.1.27 [4.2.1.71] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.2.1.98 [4.2.1.86] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.3.1.17 [4.2.1.13] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.3.1.18 [4.2.1.14] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.3.1.19 [4.2.1.16] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.3.1.20 [4.2.1.38] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.3.1.9 [4.2.1.26] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.4.1.1 [4.2.1.15] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 4.99.1.6 [4.2.1.29] | (0|0) |
(0|0|0) |
| - 1: | Tryptophan synthase [4.2.1.20] | (2|2) |
(2|1|0) |
| - 1: | Tryptophan synthase (indole-salvaging) [4.2.1.122] | (0|0) |
(0|0|0) |
| - 1: | UDP-N-acetylglucosamine 4,6-dehydratase (inverting [4.2.1.115] | (0|0) |
(0|0|0) |
| - 1: | UDP-glucose 4,6-dehydratase [4.2.1.76] | (0|0) |
(0|0|0) |
| - 1: | Urocanate hydratase [4.2.1.49] | (1|1) |
(1|0|0) |
| - 1: | Uroporphyrinogen-III synthase [4.2.1.75] | (1|1) |
(1|0|0) |
| - 1: | Xylonate dehydratase [4.2.1.82] | (0|0) |
(0|0|0) |
| - 1: | dTDP-glucose 4,6-dehydratase [4.2.1.46] | (1|1) |
(1|0|0) |
| - 1: | hydratase [4.2.1.107] | (0|0) |
(3|3|2) |
| - 1: | o-succinylbenzoate synthase [4.2.1.113] | (2|2) |
(2|1|0) |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| FAH | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Dimeric chorismate mutase | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Cyanase N-terminal domain | 0 | DIRECT |
| MaoC-like | 0 | DIRECT |
| lvD/EDD N-terminal domain-like | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| IlvD/EDD C-terminal domain-like | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| UxuA-like | 0 | DIRECT |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| Enolase | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| mono-SIS domain | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Tryptophan biosynthesis enzymes | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| DJ-1/PfpI | 0 | DIRECT |
| YjeF C-terminal domain-like | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0 | DIRECT |
| D-glucarate dehydratase-like | 0 | DIRECT |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Shikimate dehydrogenase-like | 1.746e-16 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0.0000000000000153 | DIRECT |
| Nitrile hydratase beta chain | 0.0000000000005237 | DIRECT |
| Nitrile hydratase alpha chain | 0.0000000000005237 | DIRECT |
| Acyl-carrier protein (ACP) | 0.000000006839 | DIRECT |
| Shikimate kinase (AroK) | 0.0000008776 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00000849 | DIRECT |
| FabD-like | 0.00002833 | DIRECT |
| Terpene synthases | 0.0004196 | DIRECT |
| CBS-domain pair | 0.001478 | INHERITED FROM: Cystathionine beta-synthase |
| Tyrosine-dependent oxidoreductases | 0.001489 | INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat || GDP-mannose 4,6-dehydratase |
| Enolpyruvate transferase, EPT | 0.004664 | INHERITED FROM: 3-dehydroquinate dehydratase |
| Enolase-phosphatase E1 | 0.07589 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase |
| Thiolase-related | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Cytochrome P450 | 1 | INHERITED FROM: Hydroperoxide dehydratase |
| Dehydroquinate synthase, DHQS | 1 | INHERITED FROM: 3-dehydroquinate dehydratase |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Phosphate binding protein-like | 1 | INHERITED FROM: Arogenate dehydratase || Prephenate dehydratase |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate dehydratase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| FAH | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Dimeric chorismate mutase | 0 | Direct |
| Crotonase-like | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Cyanase N-terminal domain | 0 | Direct |
| MaoC-like | 0 | Direct |
| lvD/EDD N-terminal domain-like | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| Urocanase | 0 | Direct |
| IlvD/EDD C-terminal domain-like | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| UxuA-like | 0 | Direct |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| Enolase | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| LeuD-like | 0 | Direct |
| PCD-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| mono-SIS domain | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| Tryptophan biosynthesis enzymes | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| DJ-1/PfpI | 0 | Direct |
| YjeF C-terminal domain-like | 0 | Direct |
| HemD-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Class I aldolase | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| Imidazole glycerol phosphate dehydratase | 0 | Direct |
| D-glucarate dehydratase-like | 0 | Direct |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Shikimate dehydrogenase-like | 1.746e-16 | Direct |
| Phenylalanine metabolism regulatory domain | 0.0000000000000153 | Direct |
| Nitrile hydratase beta chain | 0.0000000000005237 | Direct |
| Nitrile hydratase alpha chain | 0.0000000000005237 | Direct |
| Acyl-carrier protein (ACP) | 0.000000006839 | Direct |
| Shikimate kinase (AroK) | 0.0000008776 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00000849 | Direct |
| FabD-like | 0.00002833 | Direct |
| Terpene synthases | 0.0004196 | Direct |
| CBS-domain pair | 0.001478 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.001489 | Inherited |
| Enolpyruvate transferase, EPT | 0.004664 | Inherited |
| Enolase-phosphatase E1 | 0.07589 | Inherited |
| Thiolase-related | 1 | Inherited |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Dehydroquinate synthase, DHQS | 1 | Inherited |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Phosphate binding protein-like | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
 |
Plot tree as:
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Download Newick format tree:
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | DIRECT |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | DIRECT |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | DIRECT |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000000001518 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000003324 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.000000703 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000003083 | DIRECT |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0001942 | DIRECT |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.01154 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0.01993 | INHERITED FROM: 3-dehydroquinate dehydratase |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 1 | INHERITED FROM: Squalene--hopanol cyclase |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | Direct |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | Direct |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | Direct |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | Direct |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | Direct |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000000001518 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000003324 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.000000703 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000003083 | Direct |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0001942 | Direct |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.01154 | Inherited |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0.01993 | Inherited |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 1 | Inherited |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000004996 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000003083 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.000003544 | DIRECT |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0001088 | DIRECT |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000004996 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000003083 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.000003544 | Direct |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.0001088 | Direct |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
