| 23 | 21 | 15 | 5 | SCOP 52540 | P-loop containing nucleoside triphosphate hydrolases |
| 17 | 13 | 10 | 1 | SCOP 50249 | Nucleic acid-binding proteins |
| 10 | 8 | 7 | 4 | SCOP 54211 | Ribosomal protein S5 domain 2-like |
| 9 | 9 | 8 | 1 | SCOP 55681 | Class II aaRS and biotin synthetases |
| 7 | 7 | 5 | 2 | SCOP 51735 | NAD(P)-binding Rossmann-fold domains |
| 6 | 6 | 6 | 1 | SCOP 52374 | Nucleotidylyl transferase |
| 6 | 3 | 3 | 4 | SCOP 52518 | Thiamin diphosphate-binding fold (THDP-binding) |
| 6 | 5 | 5 | 2 | SCOP 50447 | Translation proteins |
| 6 | 4 | 4 | 0 | SCOP 55021 | ACT-like |
| 5 | 5 | 1 | 2 | SCOP 51366 | Ribulose-phoshate binding barrel |
| 5 | 3 | 3 | 2 | SCOP 53067 | Actin-like ATPase domain |
| 4 | 4 | 3 | 2 | SCOP 50104 | Translation proteins SH3-like domain |
| 4 | 2 | 2 | 1 | SCOP 54980 | EF-G C-terminal domain-like |
| 4 | 4 | 3 | 2 | SCOP 55347 | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain |
| 3 | 3 | 2 | 3 | SCOP 51569 | Aldolase |
| 3 | 3 | 2 | 1 | SCOP 52317 | Class I glutamine amidotransferase-like |
| 3 | 3 | 2 | 1 | SCOP 51905 | FAD/NAD(P)-binding domain |
| 3 | 3 | 1 | 1 | SCOP 52833 | Thioredoxin-like |
| 3 | 3 | 3 | 2 | SCOP 55120 | Pseudouridine synthase |
| 3 | 3 | 3 | 1 | SCOP 55174 | Alpha-L RNA-binding motif |
| 3 | 3 | 1 | 3 | SCOP 53383 | PLP-dependent transferases |
| 3 | 3 | 2 | 1 | SCOP 53686 | Tryptophan synthase beta subunit-like PLP-dependent enzymes |
| 3 | 3 | 2 | 0 | SCOP 54862 | 4Fe-4S ferredoxins |
| 3 | 2 | 2 | 1 | SCOP 88659 | Sigma3 and sigma4 domains of RNA polymerase sigma factors |
| 3 | 2 | 2 | 1 | SCOP 54814 | Prokaryotic type KH domain (KH-domain type II) |
| 3 | 3 | 3 | 0 | SCOP 47323 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| 2 | 1 | 1 | 1 | SCOP 56059 | Glutathione synthetase ATP-binding domain-like |
| 2 | 2 | 1 | 0 | SCOP 57829 | Zn-binding ribosomal proteins |
| 2 | 2 | 1 | 1 | SCOP 53137 | Translational machinery components |
| 2 | 2 | 2 | 0 | SCOP 53335 | S-adenosyl-L-methionine-dependent methyltransferases |
| 2 | 2 | 1 | 0 | SCOP 143800 | L28p-like |
| 2 | 2 | 1 | 1 | SCOP 75620 | Release factor |
| 2 | 2 | 2 | 0 | SCOP 103473 | MFS general substrate transporter |
| 2 | 2 | 2 | 0 | SCOP 52402 | Adenine nucleotide alpha hydrolases-like |
| 2 | 2 | 2 | 1 | SCOP 53850 | Periplasmic binding protein-like II |
| 2 | 2 | 1 | 2 | SCOP 64484 | beta and beta-prime subunits of DNA dependent RNA-polymerase |
| 2 | 2 | 2 | 1 | SCOP 50715 | Ribosomal protein L25-like |
| 2 | 2 | 1 | 1 | SCOP 52096 | ClpP/crotonase |
| 2 | 1 | 1 | 1 | SCOP 51726 | UROD/MetE-like |
| 2 | 2 | 1 | 0 | SCOP 101960 | Stabilizer of iron transporter SufD |
| 2 | 2 | 2 | 0 | SCOP 52954 | Class II aaRS ABD-related |
| 2 | 2 | 2 | 0 | SCOP 46955 | Putative DNA-binding domain |
| 2 | 2 | 2 | 0 | SCOP 52016 | LeuD/IlvD-like |
| 2 | 2 | 2 | 1 | SCOP 88946 | Sigma2 domain of RNA polymerase sigma factors |
| 2 | 1 | 1 | 0 | SCOP 56024 | Phospholipase D/nuclease |
| 2 | 2 | 2 | 1 | SCOP 52777 | CoA-dependent acyltransferases |
| 2 | 2 | 1 | 1 | SCOP 48179 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| 2 | 2 | 1 | 0 | SCOP 46589 | tRNA-binding arm |
| 2 | 2 | 2 | 1 | SCOP 56719 | Type II DNA topoisomerase |
| 2 | 1 | 1 | 1 | SCOP 52440 | PreATP-grasp domain |
| 2 | 2 | 2 | 1 | SCOP 56037 | PheT/TilS domain |
| 2 | 1 | 1 | 1 | SCOP 56053 | Ribosomal protein L6 |
| 2 | 2 | 2 | 1 | SCOP 50677 | ValRS/IleRS/LeuRS editing domain |
| 2 | 2 | 1 | 0 | SCOP 50615 | N-terminal domain of alpha and beta subunits of F1 ATP synthase |
| 2 | 1 | 1 | 0 | SCOP 49493 | HSP40/DnaJ peptide-binding domain |
| 2 | 1 | 1 | 0 | SCOP 55666 | Ribonuclease PH domain 2-like |
| 2 | 2 | 1 | 1 | SCOP 47917 | C-terminal domain of alpha and beta subunits of F1 ATP synthase |
| 1 | 1 | 1 | 1 | SCOP 53271 | PRTase-like |
| 1 | 1 | 1 | 0 | SCOP 74982 | Small protein B (SmpB) |
| 1 | 1 | 1 | 0 | SCOP 56808 | Ribosomal protein L1 |
| 1 | 1 | 1 | 1 | SCOP 47973 | Ribosomal protein S7 |
| 1 | 1 | 1 | 0 | SCOP 46911 | Ribosomal protein S18 |
| 1 | 1 | 1 | 1 | SCOP 75304 | Amidase signature (AS) enzymes |
| 1 | 1 | 1 | 1 | SCOP 56420 | Peptide deformylase |
| 1 | 1 | 1 | 1 | SCOP 56112 | Protein kinase-like (PK-like) |
| 1 | 1 | 1 | 1 | SCOP 54999 | Ribosomal protein S10 |
| 1 | 1 | 1 | 1 | SCOP 52166 | Ribosomal protein L4 |
| 1 | 1 | 1 | 0 | SCOP 54189 | Ribosomal proteins S24e, L23 and L15e |
| 1 | 1 | 1 | 1 | SCOP 54570 | Ribosomal protein S19 |
| 1 | 1 | 1 | 1 | SCOP 54843 | Ribosomal protein L22 |
| 1 | 1 | 1 | 1 | SCOP 54686 | Ribosomal protein L16p/L10e |
| 1 | 1 | 1 | 1 | SCOP 50193 | Ribosomal protein L14 |
| 1 | 1 | 1 | 1 | SCOP 55282 | RL5-like |
| 1 | 1 | 1 | 1 | SCOP 57716 | Glucocorticoid receptor-like (DNA-binding domain) |
| 1 | 1 | 1 | 1 | SCOP 56047 | Ribosomal protein S8 |
| 1 | 1 | 1 | 1 | SCOP 52080 | Ribosomal proteins L15p and L18e |
| 1 | 1 | 1 | 0 | SCOP 103491 | Preprotein translocase SecY subunit |
| 1 | 1 | 1 | 1 | SCOP 55920 | Creatinase/aminopeptidase |
| 1 | 1 | 1 | 0 | SCOP 57840 | Ribosomal protein L36 |
| 1 | 1 | 1 | 1 | SCOP 46946 | S13-like H2TH domain |
| 1 | 1 | 1 | 1 | SCOP 64263 | Prokaryotic ribosomal protein L17 |
| 1 | 1 | 1 | 0 | SCOP 143034 | L35p-like |
| 1 | 1 | 1 | 1 | SCOP 74731 | Ribosomal protein L20 |
| 1 | 1 | 1 | 1 | SCOP 141091 | L21p-like |
| 1 | 1 | 1 | 0 | SCOP 110324 | Ribosomal L27 protein-like |
| 1 | 1 | 1 | 0 | SCOP 47336 | ACP-like |
| 1 | 1 | 1 | 1 | SCOP 53659 | Isocitrate/Isopropylmalate dehydrogenase-like |
| 1 | 1 | 1 | 0 | SCOP 82649 | SufE/NifU |
| 1 | 1 | 1 | 0 | SCOP 160369 | Ribosomal protein L10-like |
| 1 | 1 | 1 | 0 | SCOP 46992 | Ribosomal protein S20 |
| 1 | 1 | 1 | 0 | SCOP 55486 | Metalloproteases ("zincins"), catalytic domain |
| 1 | 1 | 1 | 1 | SCOP 50129 | GroES-like |
| 1 | 1 | 1 | 1 | SCOP 52943 | ATP synthase (F1-ATPase), gamma subunit |
| 1 | 1 | 1 | 0 | SCOP 81333 | F1F0 ATP synthase subunit C |
| 1 | 1 | 1 | 1 | SCOP 52161 | Ribosomal protein L13 |
| 1 | 1 | 1 | 0 | SCOP 47060 | S15/NS1 RNA-binding domain |
| 1 | 1 | 1 | 1 | SCOP 53633 | Carbamate kinase-like |
| 1 | 1 | 1 | 0 | SCOP 54565 | Ribosomal protein S16 |
| 1 | 1 | 1 | 1 | SCOP 51730 | FAD-linked oxidoreductase |
| 1 | 1 | 1 | 0 | SCOP 51161 | Trimeric LpxA-like enzymes |
| 1 | 1 | 1 | 1 | SCOP 103263 | Chorismate synthase, AroC |
| 1 | 1 | 1 | 0 | SCOP 89360 | HesB-like domain |
| 1 | 1 | 1 | 1 | SCOP 56770 | HydA/Nqo6-like |
| 1 | 1 | 1 | 0 | SCOP 54292 | 2Fe-2S ferredoxin-like |
| 1 | 1 | 1 | 0 | SCOP 52313 | Ribosomal protein S2 |
| 1 | 1 | 1 | 0 | SCOP 102114 | Radical SAM enzymes |
| 1 | 1 | 1 | 1 | SCOP 55205 | EPT/RTPC-like |
| 1 | 1 | 1 | 1 | SCOP 52304 | Type II 3-dehydroquinate dehydratase |
| 1 | 1 | 1 | 0 | SCOP 48576 | Terpenoid synthases |
| 1 | 1 | 1 | 1 | SCOP 81452 | Cytochrome c oxidase subunit III-like |
| 1 | 1 | 1 | 0 | SCOP 46561 | Ribosomal protein L29 (L29p) |
| 1 | 1 | 1 | 1 | SCOP 56796 | Dehydroquinate synthase-like |
| 1 | 1 | 1 | 0 | SCOP 54995 | Ribosomal protein S6 |
| 1 | 1 | 1 | 1 | SCOP 53187 | Zn-dependent exopeptidases |
| 1 | 1 | 1 | 1 | SCOP 56235 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) |
| 1 | 1 | 1 | 0 | SCOP 54534 | FKBP-like |
| 1 | 1 | 1 | 1 | SCOP 56322 | ADC synthase |
| 1 | 1 | 1 | 0 | SCOP 55257 | RBP11-like subunits of RNA polymerase |
| 1 | 1 | 1 | 1 | SCOP 81442 | Cytochrome c oxidase subunit I-like |
| 1 | 1 | 1 | 1 | SCOP 141734 | HisI-like |
| 1 | 1 | 1 | 1 | SCOP 55931 | Glutamine synthetase/guanido kinase |
| 1 | 1 | 1 | 1 | SCOP 54631 | CBS-domain pair |
| 1 | 1 | 1 | 0 | SCOP 143243 | Nqo5-like |
| 1 | 1 | 1 | 1 | SCOP 55874 | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase |
| 1 | 1 | 1 | 0 | SCOP 117916 | Fe-S cluster assembly (FSCA) domain-like |
| 1 | 1 | 1 | 0 | SCOP 51230 | Single hybrid motif |
| 1 | 1 | 1 | 1 | SCOP 49503 | Cupredoxins |
| 1 | 1 | 1 | 0 | SCOP 89550 | PHP domain-like |
| 1 | 1 | 1 | 1 | SCOP 56762 | HydB/Nqo4-like |
| 1 | 1 | 1 | 1 | SCOP 52467 | DHS-like NAD/FAD-binding domain |
| 1 | 1 | 1 | 0 | SCOP 54736 | ClpS-like |
| 1 | 1 | 1 | 1 | SCOP 53732 | Aconitase iron-sulfur domain |
| 1 | 1 | 1 | 1 | SCOP 55200 | Translation initiation factor IF3, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 88697 | PUA domain-like |
| 1 | 1 | 1 | 0 | SCOP 89095 | GatB/YqeY motif |
| 1 | 1 | 1 | 0 | SCOP 48600 | Chorismate mutase II |
| 1 | 1 | 1 | 0 | SCOP 103088 | OmpA-like |
| 1 | 1 | 1 | 0 | SCOP 55826 | YbaK/ProRS associated domain |
| 1 | 1 | 1 | 1 | SCOP 118215 | Proton glutamate symport protein |
| 1 | 1 | 1 | 0 | SCOP 101386 | all-alpha NTP pyrophosphatases |
| 1 | 1 | 1 | 0 | SCOP 52335 | Methylglyoxal synthase-like |
| 1 | 1 | 1 | 0 | SCOP 158791 | MgtE N-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 46565 | Chaperone J-domain |
| 1 | 1 | 1 | 0 | SCOP 55186 | ThrRS/AlaRS common domain |
| 1 | 1 | 1 | 1 | SCOP 50465 | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 55424 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain |
| 1 | 1 | 1 | 1 | SCOP 52343 | Ferredoxin reductase-like, C-terminal NADP-linked domain |
| 1 | 1 | 1 | 0 | SCOP 48024 | N-terminal domain of DnaB helicase |
| 1 | 1 | 1 | 1 | SCOP 48592 | GroEL equatorial domain-like |
| 1 | 1 | 1 | 0 | SCOP 53706 | Formate dehydrogenase/DMSO reductase, domains 1-3 |
| 1 | 1 | 1 | 0 | SCOP 57938 | DnaJ/Hsp40 cysteine-rich domain |
| 1 | 1 | 1 | 0 | SCOP 46906 | Ribosomal protein L11, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 53223 | Aminoacid dehydrogenase-like, N-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 54821 | Ribosomal protein S3 C-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 52922 | TK C-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 81336 | F1F0 ATP synthase subunit A |
| 1 | 1 | 1 | 1 | SCOP 47789 | C-terminal domain of RNA polymerase alpha subunit |
| 1 | 1 | 1 | 0 | SCOP 51344 | Epsilon subunit of F1F0-ATP synthase N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 55658 | L9 N-domain-like |
| 1 | 1 | 1 | 0 | SCOP 82679 | N-utilization substance G protein NusG, N-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 52418 | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| 1 | 1 | 1 | 1 | SCOP 48334 | DNA repair protein MutS, domain III |
| 1 | 1 | 1 | 0 | SCOP 58014 | Coiled-coil domain of nucleotide exchange factor GrpE |
| 1 | 1 | 1 | 1 | SCOP 81464 | Cytochrome c oxidase subunit II-like, transmembrane region |
| 1 | 1 | 1 | 1 | SCOP 161093 | MgtE membrane domain-like |
| 1 | 1 | 1 | 1 | SCOP 140990 | FtsH protease domain-like |
| 1 | 1 | 1 | 1 | SCOP 53671 | Aspartate/ornithine carbamoyltransferase |
| 1 | 1 | 1 | 0 | SCOP 142984 | Nqo1 middle domain-like |
| 1 | 1 | 1 | 0 | SCOP 48163 | An anticodon-binding domain of class I aminoacyl-tRNA synthetases |
| 1 | 1 | 1 | 1 | SCOP 52021 | Carbamoyl phosphate synthetase, small subunit N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 54791 | Eukaryotic type KH-domain (KH-domain type I) |
| 1 | 1 | 1 | 1 | SCOP 52029 | GroEL apical domain-like |
| 1 | 1 | 1 | 1 | SCOP 101904 | GyrA/ParC C-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 63380 | Riboflavin synthase domain-like |
| 1 | 1 | 1 | 0 | SCOP 48300 | Ribosomal protein L7/12, oligomerisation (N-terminal) domain |
| 1 | 1 | 1 | 1 | SCOP 100920 | Heat shock protein 70kD (HSP70), peptide-binding domain |
| 1 | 1 | 1 | 0 | SCOP 46934 | UBA-like |
| 1 | 1 | 1 | 0 | SCOP 47648 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 54768 | dsRNA-binding domain-like |
| 1 | 1 | 1 | 0 | SCOP 140490 | Nqo1C-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 55031 | Bacterial exopeptidase dimerisation domain |
| 1 | 1 | 1 | 1 | SCOP 143975 | IlvD/EDD N-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 46557 | GreA transcript cleavage protein, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 54991 | Anticodon-binding domain of PheRS |
| 1 | 1 | 1 | 1 | SCOP 55271 | DNA repair protein MutS, domain I |
| 1 | 1 | 1 | 1 | SCOP 48108 | Carbamoyl phosphate synthetase, large subunit connection domain |
| 1 | 1 | 1 | 0 | SCOP 82051 | Obg GTP-binding protein N-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 142019 | Nqo1 FMN-binding domain-like |
| 1 | 1 | 1 | 0 | SCOP 55261 | GAD domain-like |
| 1 | 1 | 1 | 0 | SCOP 54713 | Elongation factor Ts (EF-Ts), dimerisation domain |
| 1 | 1 | 1 | 1 | SCOP 54747 | Ribosomal L11/L12e N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 81886 | Helical scaffold and wing domains of SecA |
| 1 | 1 | 1 | 0 | SCOP 54849 | GroEL-intermediate domain like |
| 1 | 1 | 1 | 0 | SCOP 89000 | post-HMGL domain-like |
| 1 | 1 | 1 | 0 | SCOP 52156 | Initiation factor IF2/eIF5b, domain 3 |
| 1 | 1 | 1 | 0 | SCOP 51064 | Head domain of nucleotide exchange factor GrpE |
| 1 | 1 | 1 | 0 | SCOP 47005 | Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex |
| 1 | 1 | 1 | 0 | SCOP 55653 | Ribosomal protein L9 C-domain |
| 1 | 1 | 1 | 1 | SCOP 56553 | Insert subdomain of RNA polymerase alpha subunit |
| 1 | 1 | 1 | 0 | SCOP 54364 | Translation initiation factor IF3, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 69705 | Transcription factor NusA, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 53150 | DNA repair protein MutS, domain II |
| 1 | 1 | 1 | 0 | SCOP 81767 | Pre-protein crosslinking domain of SecA |
| 1 | 1 | 1 | 0 | SCOP 81799 | Putative methyltransferase TM0872, insert domain |
| 1 | 1 | 1 | 0 | SCOP 82829 | MesJ substrate recognition domain-like |
| 1 | 1 | 1 | 0 | SCOP 46915 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
