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  Home > Genomes > Drosophila melanogaster FlyBase 5.12 > FBpp0291363

Domain assignment for FBpp0291363 from Drosophila melanogaster FlyBase 5.12

Domain architecture

Domain assignment details

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Strong hits

Sequence:  FBpp0291363
Domain Number 1 Region: 2515-2777
Classification Level Classification E-value
Superfamily YWTD domain 4.31e-46
Family YWTD domain 0.0000167
Further Details:      
 
Domain Number 2 Region: 1561-1820
Classification Level Classification E-value
Superfamily YWTD domain 7.71e-45
Family YWTD domain 0.00000517
Further Details:      
 
Domain Number 3 Region: 3337-3601
Classification Level Classification E-value
Superfamily YWTD domain 3.01e-42
Family YWTD domain 0.00000463
Further Details:      
 
Domain Number 4 Region: 838-1070
Classification Level Classification E-value
Superfamily YWTD domain 2.22e-40
Family YWTD domain 0.0000242
Further Details:      
 
Domain Number 5 Region: 4211-4483
Classification Level Classification E-value
Superfamily YWTD domain 3.27e-37
Family YWTD domain 0.0000202
Further Details:      
 
Domain Number 6 Region: 500-735
Classification Level Classification E-value
Superfamily YWTD domain 1.44e-35
Family YWTD domain 0.0000392
Further Details:      
 
Domain Number 7 Region: 2195-2455
Classification Level Classification E-value
Superfamily YWTD domain 1.7e-34
Family YWTD domain 0.0000417
Further Details:      
 
Domain Number 8 Region: 1867-2143
Classification Level Classification E-value
Superfamily YWTD domain 1.44e-29
Family YWTD domain 0.00051
Further Details:      
 
Domain Number 9 Region: 1477-1555,1848-1861,2139-2187
Classification Level Classification E-value
Superfamily Growth factor receptor domain 1.88e-19
Family Growth factor receptor domain 0.014
Further Details:      
 
Domain Number 10 Region: 389-489,758-808
Classification Level Classification E-value
Superfamily Growth factor receptor domain 1.73e-18
Family Growth factor receptor domain 0.014
Further Details:      
 
Domain Number 11 Region: 2859-2902
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000000209
Family LDL receptor-like module 0.00074
Further Details:      
 
Domain Number 12 Region: 1182-1223
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000000209
Family LDL receptor-like module 0.00081
Further Details:      
 
Domain Number 13 Region: 2984-3026
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000000144
Family LDL receptor-like module 0.001
Further Details:      
 
Domain Number 14 Region: 326-367
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000000353
Family LDL receptor-like module 0.0012
Further Details:      
 
Domain Number 15 Region: 3910-3947
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000000523
Family LDL receptor-like module 0.00089
Further Details:      
 
Domain Number 16 Region: 3699-3739
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000000707
Family LDL receptor-like module 0.0018
Further Details:      
 
Domain Number 17 Region: 3951-3988
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000111
Family LDL receptor-like module 0.0011
Further Details:      
 
Domain Number 18 Region: 2824-2862
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000275
Family LDL receptor-like module 0.00076
Further Details:      
 
Domain Number 19 Region: 1223-1261
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000275
Family LDL receptor-like module 0.00079
Further Details:      
 
Domain Number 20 Region: 3784-3822
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000628
Family LDL receptor-like module 0.00087
Further Details:      
 
Domain Number 21 Region: 1267-1304
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000654
Family LDL receptor-like module 0.001
Further Details:      
 
Domain Number 22 Region: 3994-4031
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000693
Family LDL receptor-like module 0.0019
Further Details:      
 
Domain Number 23 Region: 4126-4183
Classification Level Classification E-value
Superfamily EGF/Laminin 0.00000000718
Family EGF-type module 0.011
Further Details:      
 
Domain Number 24 Region: 155-190
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000811
Family LDL receptor-like module 0.0012
Further Details:      
 
Domain Number 25 Region: 3125-3160
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000824
Family LDL receptor-like module 0.0011
Further Details:      
 
Domain Number 26 Region: 3033-3069
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000115
Family LDL receptor-like module 0.0011
Further Details:      
 
Domain Number 27 Region: 3165-3204
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000144
Family LDL receptor-like module 0.0013
Further Details:      
 
Domain Number 28 Region: 3742-3780
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000144
Family LDL receptor-like module 0.00087
Further Details:      
 
Domain Number 29 Region: 1147-1182
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000222
Family LDL receptor-like module 0.001
Further Details:      
 
Domain Number 30 Region: 1303-1344
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000314
Family LDL receptor-like module 0.0014
Further Details:      
 
Domain Number 31 Region: 1355-1387
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000327
Family LDL receptor-like module 0.001
Further Details:      
 
Domain Number 32 Region: 2900-2941
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000034
Family LDL receptor-like module 0.0011
Further Details:      
 
Domain Number 33 Region: 287-327
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000366
Family LDL receptor-like module 0.0015
Further Details:      
 
Domain Number 34 Region: 3210-3225,3258-3329,3595-3670
Classification Level Classification E-value
Superfamily Growth factor receptor domain 0.0000000408
Family Growth factor receptor domain 0.02
Further Details:      
 
Domain Number 35 Region: 4082-4118
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000602
Family LDL receptor-like module 0.002
Further Details:      
 
Domain Number 36 Region: 3868-3906
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000811
Family LDL receptor-like module 0.00098
Further Details:      
 
Domain Number 37 Region: 4037-4073
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000864
Family LDL receptor-like module 0.0024
Further Details:      
 
Domain Number 38 Region: 1390-1424
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000157
Family LDL receptor-like module 0.0016
Further Details:      
 
Domain Number 39 Region: 2948-2986
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000183
Family LDL receptor-like module 0.0012
Further Details:      
 
Domain Number 40 Region: 3661-3696
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000196
Family LDL receptor-like module 0.0008
Further Details:      
 
Domain Number 41 Region: 1434-1469
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000576
Family LDL receptor-like module 0.003
Further Details:      
 
Domain Number 42 Region: 3820-3864
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000589
Family LDL receptor-like module 0.0022
Further Details:      
 
Domain Number 43 Region: 191-237
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000576
Family LDL receptor-like module 0.0019
Further Details:      
 
Domain Number 44 Region: 3080-3118
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000262
Family LDL receptor-like module 0.0018
Further Details:      
 
Domain Number 45 Region: 4541-4573
Classification Level Classification E-value
Superfamily EGF/Laminin 0.0000632
Family EGF-type module 0.016
Further Details:      
 
Weak hits

Sequence:  FBpp0291363
Domain Number - Region: 263-288
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000122
Family LDL receptor-like module 0.0026
Further Details:      
 
Domain Number - Region: 2782-2841
Classification Level Classification E-value
Superfamily EGF/Laminin 0.00259
Family EGF-type module 0.042
Further Details:      
 
Domain Number - Region: 4487-4512
Classification Level Classification E-value
Superfamily EGF/Laminin 0.009
Family EGF-type module 0.024
Further Details:      
 
Domain Number - Region: 1823-1859
Classification Level Classification E-value
Superfamily EGF/Laminin 0.0137
Family EGF-type module 0.021
Further Details:      
 
Domain Number - Region: 2459-2518
Classification Level Classification E-value
Superfamily EGF/Laminin 0.0274
Family EGF-type module 0.0096
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Molecular Function IC (bits) H-Score
Biological Process IC (bits) H-Score
Cellular Component IC (bits) H-Score

Protein sequence

External link(s) Protein: FBpp0291363   Gene: FBgn0261260   Transcript: FBtr0302153
Sequence length 4769
Comment type=protein; loc=X:complement(9254347..9254567,9254639..9254886,9254966..9257152,9257214..9257526,9257590..9259094,9259159..9259565,9259625..9259836,9259911..9265571,9265652..9267970,9269037..9269291,9269390..9269662,9276643..9276774,9277240..9277398,9366032..9366449); ID=FBpp0291363; name=Megalin-PA; parent=FBgn0261260,FBtr0302153; dbxref=REFSEQ:NP_001096924,GB_protein:ABW09371,FlyBase:FBpp0291363,FlyBase_Annotation_IDs:CG42611-PA,FlyMine:FBpp0291363,modMine:FBpp0291363; MD5=e18abd541e3f5a5bb3c314006bc6c791; length=4769; release=r5.30; species=Dmel;
Sequence 
MNPTPVGIGFGFGRKPPSKARMRSRWRPPSATTLLTHDPANGDSHTAADPLQVTDAAPSG
PPSSSSSSPIGDRHSQHHSSSAIDRRLQQQQHHQSPQHHRQRGQLTTLALLLLALVAISN
LETLLAVRTEGPRNRHGSPGGSLASTGGSSSGINTECPTDSFRCNNGKCISHHWVCNYQK
DCDDGEDEMQSCPPPECETPQLNCGQYTFNKTYCIPPHYRCDMIEDCEDKSDEAQCTYRK
CQHTDLFCNTPTGAPAEGARLTGPCVPKEKRCDGYLDCRTGRDEVGCSGVACRLDQFRCA
NGLKCIDAALKCNHRDDCGDNSDEQGCNFPPCHHAQFRCTNALCIPYNFHCDGYHDCADK
SDEANCTAIACPDNKHLCPRGGASGTPKCILKSQLCDGKRDCEDGSDEETNCSIASCPAL
SCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDLDECAEWGHCDQLCTNTLGSYTCQCAQG
YTLINDSKCIAPDANNLQLIFAHDRAIMRMLPHGSEPKILANATAAAGVTFHYARNTLYW
SDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWAPVALAVDWVGDKIYVADLVGQKIDVFEL
SGQWHAVVLGSNLTSPADLALDPTAGLMFVADGGQVLRAHMDGTHARSIVSEAAYKASGV
TVDIISKRVFWCDSLLDYIESVDYEGAHRVMVLRGQQVPSPSRLALFENRIYWTDATKQG
IMSVDKFEGPTSIQVTYKAKDIREPKGIIAVHALSQPRVSNPCGNNNGGCNHMCIVTAVK
GAPTGLGFRCACSTGYQLETDLKLCKPVSEFLMYSQQRFIKGKVLEPVIEGFSDAIMPVV
SRRARFVGLDFDARDEFIYYSDVLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKN
LYYIDSRKGTLNVLSTRNVTHRRTLLKNLKRPRAIVVHPNRGFIFFSEWDRPANITRANT
DGSGLLVFKNVTLGWPNGLSIDFKEDRVYWCDALLDHVQHANLDGTDIKTVNSRLVRHPF
SIVIHNDWMYITDWRLDAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIADTQP
CHRNNGGCQKICFAVPIGASNGTDGVTTSSPSFGRLQSRCSCPYGERLADDQVSCIPDPS
AEPPVQPCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGR
CIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEG
DFCAEKTCAYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQ
CVEESYKCDGIPDCNDGSDEVGCPSMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSD
HSDEQDCGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQ
WQCPGVSERCVNITSVCDDTPDCPNGSDEGEGCDLAECEHQAGQCSSFCQKTPNGALCVC
PPGSEIGEDGYTCIDSNECDPPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTA
AFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISRLDRGM
EPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMC
IDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSK
LDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTV
VSHLISQPLSIHVHHASLQPMTPNPCAGSRCQHLCLLSPSAPEGYSCKCRPGFKLLSEGR
CIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDRKGETLYWVQGRE
DDDENCTIYTTPYGGGNKTLFLGIENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRVD
GKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPIV
VFQEFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLGIL
DHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMIYKKRALMQHPCQTNNGGCKH
LCIPGPGATRTCACGIGYRKENEINCVAYKIFAVVSQLDMIRGYSLSDSSEAMVPISGPG
HHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVA
GNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIG
KALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISYNGANRKIIRRDLP
NPMGIAVYLNDVYWVDRNLMTVFKASKHSANETATSVRTNLEKLRDIAIYNINNQPQDDT
NPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCECATGKLSADERKCEVVNEYLVFAT
RTEIRAVNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRMLYTQIRPWAKIAYTKANKPGH
DDITVVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSELVMIARVERPRAIVLD
PCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVR
EKIERSDLDGQNRELLVAATIYPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKR
LEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRMCA
PRNNTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCI
FKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDET
HERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCP
NHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDC
LDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLH
NCATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNF
KCIRNQSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADES
DEPAHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGAC
SQHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLM
HQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIA
IDWVGRKLYWLDRHSKNLDVSELDGSKRKTLRSGVVDPRAIVVHPGIGYLYFTSWHLQAY
IAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVL
SGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQ
LPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCV
ANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAGTFQCKNTNCTPS
ATICDGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSWRCDGDADCKDGSDEDPAVC
FKRTCDPKTEFSCKNGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQRCPGQSNY
RCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNRCIPKQWMCDFADDCGDASD
ENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQCA
SGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDD
CGDGSDEDPSVCSDFNCDTLRRFQCSNERCVARYQICDGVDNCGDGSDENNMTLCASKQK
PCDLYTQYQCANKHCIERSQVCDFSDDCGDASDELGCHHTSSCSEANRGGCQQHCHNLTD
GGYICTCYPGYIIAADNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREGFHLTDGAS
GVCRAEKEDVILLFVNGQEIRGLNWHKSEEFAVIAAEKRIEALDYDAQQQIVFWADSYDK
TIKRSYMVNAIDGRAKIGFAQDLNMKGGSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVM
VAKTDGRYRRSIVNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEM
IRHPAGLTIDYSQDHIIYWVDTKLNAIESMRADGSRRKAIVRGDQLRHPVSLDLFESNMF
WMTRDTGELVRQDKFGRGVQVVLHRYIVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLL
VPGGHRCACPDASGPPPSHRSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELLCE
CRTQFVGEHCETSTMGAFGHGDANVTAVVVPIMVILLVMMAAAGAWYVIRKRPFGKLARM
PAMTSSQSVTFRHGSNVEFNESGFPGASAPGAGDVAPIEGYNLQTVNANKARDFANPMYD
AVQSGTTADPGMGNGSGIYDVPGEPSAKVKSMGHHAGGSFTEPASAIIAPSSITHKASPQ
LQLRTRELDPSADTGKDTQFLVEEDKSEC
Download sequence
Identical sequences A8JTM7
FBpp0291363 FBpp0291364 FBpp0291363 NP_001096924.2.81976 NP_001285053.1.81976 NP_001285054.1.81976 NP_572563.3.81976

Jump to [ Top of page · Domain architecture · Domain assignment details · Most Informative Gene Ontologies ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.