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  Home > Genomes > Equus caballus 76_2 > ENSECAP00000015453

Domain assignment for ENSECAP00000015453 from Equus caballus 76_2

Domain architecture

Domain assignment details

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Strong hits

Sequence:  ENSECAP00000015453
Domain Number 1 Region: 2054-2213
Classification Level Classification E-value
Superfamily Galactose-binding domain-like 6.17e-16
Family Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) 0.0035
Further Details:      
 
Domain Number 2 Region: 2530-2587
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000000000275
Family TSP-1 type 1 repeat 0.00048
Further Details:      
 
Domain Number 3 Region: 2692-2744
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000000000314
Family TSP-1 type 1 repeat 0.00084
Further Details:      
 
Domain Number 4 Region: 3991-4048
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000000000968
Family TSP-1 type 1 repeat 0.00029
Further Details:      
 
Domain Number 5 Region: 4245-4299
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000000000115
Family TSP-1 type 1 repeat 0.00084
Further Details:      
 
Domain Number 6 Region: 2960-3018
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000000000131
Family TSP-1 type 1 repeat 0.00057
Further Details:      
 
Domain Number 7 Region: 3233-3281
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000000000196
Family TSP-1 type 1 repeat 0.00048
Further Details:      
 
Domain Number 8 Region: 3801-3850
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000000157
Family TSP-1 type 1 repeat 0.00075
Further Details:      
 
Domain Number 9 Region: 2807-2861
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000000249
Family TSP-1 type 1 repeat 0.00061
Further Details:      
 
Domain Number 10 Region: 3621-3671
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000000196
Family TSP-1 type 1 repeat 0.00054
Further Details:      
 
Domain Number 11 Region: 1265-1328
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.000000000687
Family ATI-like 0.045
Further Details:      
 
Domain Number 12 Region: 3932-3991
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000017
Family TSP-1 type 1 repeat 0.001
Further Details:      
 
Domain Number 13 Region: 2440-2476
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000183
Family LDL receptor-like module 0.0012
Further Details:      
 
Domain Number 14 Region: 1411-1448
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000038
Family LDL receptor-like module 0.0014
Further Details:      
 
Domain Number 15 Region: 2221-2257
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000000537
Family LDL receptor-like module 0.0014
Further Details:      
 
Domain Number 16 Region: 2477-2530
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000000562
Family TSP-1 type 1 repeat 0.0027
Further Details:      
 
Domain Number 17 Region: 3164-3224
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000000615
Family TSP-1 type 1 repeat 0.0025
Further Details:      
 
Domain Number 18 Region: 3067-3124
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.00000000654
Family BSTI 0.042
Further Details:      
 
Domain Number 19 Region: 3451-3498
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000012
Family TSP-1 type 1 repeat 0.00088
Further Details:      
 
Domain Number 20 Region: 3387-3431
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000157
Family TSP-1 type 1 repeat 0.0009
Further Details:      
 
Domain Number 21 Region: 4607-4660
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000157
Family TSP-1 type 1 repeat 0.0014
Further Details:      
 
Domain Number 22 Region: 4815-4872
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.0000000229
Family BSTI 0.024
Further Details:      
 
Domain Number 23 Region: 1370-1406
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000288
Family LDL receptor-like module 0.0013
Further Details:      
 
Domain Number 24 Region: 1799-1858
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.0000000343
Family BSTI 0.076
Further Details:      
 
Domain Number 25 Region: 1447-1482
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000038
Family LDL receptor-like module 0.0014
Further Details:      
 
Domain Number 26 Region: 1486-1524
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000000445
Family LDL receptor-like module 0.0023
Further Details:      
 
Domain Number 27 Region: 4975-5042
Classification Level Classification E-value
Superfamily FnI-like domain 0.0000000638
Family VWC domain 0.051
Further Details:      
 
Domain Number 28 Region: 816-876
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.0000000687
Family ATI-like 0.064
Further Details:      
 
Domain Number 29 Region: 458-520
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.0000000834
Family BSTI 0.082
Further Details:      
 
Domain Number 30 Region: 1738-1791
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000000863
Family TSP-1 type 1 repeat 0.00094
Further Details:      
 
Domain Number 31 Region: 4761-4810
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000105
Family TSP-1 type 1 repeat 0.0012
Further Details:      
 
Domain Number 32 Region: 2752-2800
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000118
Family TSP-1 type 1 repeat 0.00076
Further Details:      
 
Domain Number 33 Region: 1596-1631
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000209
Family LDL receptor-like module 0.0024
Further Details:      
 
Domain Number 34 Region: 4921-4985
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.000000589
Family ATI-like 0.02
Further Details:      
 
Domain Number 35 Region: 1556-1593
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.000000798
Family LDL receptor-like module 0.0012
Further Details:      
 
Domain Number 36 Region: 4146-4201
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.000000889
Family TSP-1 type 1 repeat 0.0021
Further Details:      
 
Domain Number 37 Region: 2377-2416
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.00000089
Family LDL receptor-like module 0.0019
Further Details:      
 
Domain Number 38 Region: 3022-3062
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000106
Family TSP-1 type 1 repeat 0.0027
Further Details:      
 
Domain Number 39 Region: 4048-4107
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.00000142
Family BSTI 0.05
Further Details:      
 
Domain Number 40 Region: 4675-4723
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.00000278
Family ATI-like 0.057
Further Details:      
 
Domain Number 41 Region: 2646-2710
Classification Level Classification E-value
Superfamily FnI-like domain 0.00000303
Family VWC domain 0.064
Further Details:      
 
Domain Number 42 Region: 3870-3918
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000327
Family TSP-1 type 1 repeat 0.0017
Further Details:      
 
Domain Number 43 Region: 4307-4357
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00000772
Family TSP-1 type 1 repeat 0.0035
Further Details:      
 
Domain Number 44 Region: 4417-4473
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.00000867
Family ATI-like 0.011
Further Details:      
 
Domain Number 45 Region: 3506-3566
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.00000899
Family ATI-like 0.076
Further Details:      
 
Domain Number 46 Region: 3296-3345
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.0000105
Family BSTI 0.045
Further Details:      
 
Domain Number 47 Region: 963-1010
Classification Level Classification E-value
Superfamily FnI-like domain 0.0000146
Family VWC domain 0.057
Further Details:      
 
Domain Number 48 Region: 1644-1677
Classification Level Classification E-value
Superfamily LDL receptor-like module 0.0000196
Family LDL receptor-like module 0.0026
Further Details:      
 
Domain Number 49 Region: 866-935
Classification Level Classification E-value
Superfamily FnI-like domain 0.0000303
Family Fibronectin type I module 0.033
Further Details:      
 
Domain Number 50 Region: 2861-2926
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.0000409
Family BSTI 0.049
Further Details:      
 
Domain Number 51 Region: 1895-1953
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.0000589
Family TSP-1 type 1 repeat 0.0014
Further Details:      
 
Domain Number 52 Region: 1951-2014
Classification Level Classification E-value
Superfamily FnI-like domain 0.0000921
Family Fibronectin type I module 0.07
Further Details:      
 
Weak hits

Sequence:  ENSECAP00000015453
Domain Number - Region: 3769-3818
Classification Level Classification E-value
Superfamily FnI-like domain 0.000126
Family VWC domain 0.093
Further Details:      
 
Domain Number - Region: 3675-3732
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.000147
Family BSTI 0.03
Further Details:      
 
Domain Number - Region: 2624-2655
Classification Level Classification E-value
Superfamily Serine protease inhibitors 0.000196
Family ATI-like 0.02
Further Details:      
 
Domain Number - Region: 4199-4262
Classification Level Classification E-value
Superfamily FnI-like domain 0.000293
Family VWC domain 0.074
Further Details:      
 
Domain Number - Region: 4360-4409
Classification Level Classification E-value
Superfamily TSP-1 type 1 repeat 0.00471
Family TSP-1 type 1 repeat 0.005
Further Details:      
 
Domain Number - Region: 4118-4146
Classification Level Classification E-value
Superfamily PMP inhibitors 0.0162
Family PMP inhibitors 0.0027
Further Details:      
 
Domain Number - Region: 527-551
Classification Level Classification E-value
Superfamily PMP inhibitors 0.0942
Family PMP inhibitors 0.0039
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Molecular Function IC (bits) H-Score
Cellular Component IC (bits) H-Score
Biological Process IC (bits) H-Score

Protein sequence

External link(s) Protein: ENSECAP00000015453   Gene: ENSECAG00000016582   Transcript: ENSECAT00000018914
Sequence length 5146
Comment pep:novel chromosome:EquCab2:4:101750309:101803348:1 gene:ENSECAG00000016582 transcript:ENSECAT00000018914 gene_biotype:protein_coding transcript_biotype:protein_coding
Sequence 
MLLPALLFGTAWALANGRWCEQTETILGEEEVTPRQEELVPCTSLYHYQRLGWRLDLSRS
GPAGLCPIYKPPETRPATWNRTVRACCPGWGGTHCTLVLADASPEGHCFATWQCQLRAGL
ANASAGSLEECCARPWGQSWQDGSSQACLSCSSLRPPGGTPSPALLRPLPGAVAQLWSQH
QRPSATCTTWSGFHYRTFDGRHYHFLGRCTYLLVGAVDSTWAVHLMPREHCPPPGHCQLA
RVMMGPEEVLVQGGNVSVNGQLVSDGESRLLPGLSLQWQGDWLVLSGGLGVVVRLDRSSS
VSVSVDHKLQGQTQGLCGVYNGRPEDDFLEPGGGLGLAATFGNSWRLPDSEPGCLDAVEV
APGCDDPLRGTEAGMQAGQLRAEAQDVCHQLLDGPFRECHAQVPPAEYHEACLFAYCSGA
PAGSGQEGRREAVCATLAHYAQDCAKRRIHVRWRKPGFCERLCPGGQLYSDCASACPPSC
AAAGAGGEGSCGEECVSGCECAPGLFWDGALCVPAARCPCYHRRQRYSPGDTVRQLCNPC
VCQDGRWLCAQAPVAAAHPLLPPGAQNKTFSQSFRIVGQAGLVTGCLQDFTKGQLLIVLE
HGTCDSGSCLHAISVSLGDTHVQLRDSGAVLVDGQDVGLPWDGPGGLHLSRASSTFLVLR
WPGAQVLWGVSDPAAYITLDPRHADQVQGLCGTFTRNQQDDFLTPAGDVETSIAAFASKF
QVGDEGRCPSEDSTLLSLCSTHAQHHIFSEAACAVLRGPAFQECHGLVDREPFHLRCLAA
MCGCAPGRDCLCPVLAAYARRCAQEGASLLWRNQTLCPVLCPGGQEYQECAPVCGRNCGE
PEDCGELGGCVAGCTCPLGLLWDPEGQCVPPSLCPCQLGAHRYAPGSATMRDCNRCVCQE
RGLWNCTARRCTPPRAYCPQELVYVPGACLLTCDSPTANHSCPPGSTGGCVCPSGTVLLD
ERCVPPELCPCRHSGQWYPPNATIQEDCNICVCQGRQWHCTGRRCGGRCQASGAPHYVTF
DGLALTFPGACEYLLVREASGRFTVSAQNLPCGASGLTCTKALTVRLQSTVVHMLRGQAV
TVNGVSVTPPKVYTGPGLCLRQAGLFLLLSTRLGLSLLWDGGTRVLLQLSPEFRGRVAGL
CGDFDGDASNDLRSRQGVLEPTAELAAHSWRLSPLCPEPGDLPHPCTVNTHRASWAHARC
GLMLQPLFARCHVEVPPQQHYEWCVYDACGCDSGGDCECLCSAIAAYADECARHGLHVRW
RSQELCPLQCEGGQVYEACGPTCPPTCHDHDPEPGWHCQAVACVEGCFCPEGTLLHGGFC
LEPTSCPCEWGGSFFPPGTVLQKDCGNCTCQESQWLCGGDGTHCEELVPGCAEGEAPCQE
SGHCVPHEWLCDNQDDCGDGSDEEGCATPGCGEGQMSCSSGLCLPLVQLCDGQDDCGDGT
DEQGCPCPQDSLACADGRCLPPALLCDGHPDCPDAADEESCLGQVNCTLGEVSCVDGTCV
GAIQLCDGIWDCPDGADEGPGHCPLPSLPTPPAGTFPGHPAGSRLNQLPWPAPVLVTPPC
APFEFPCGSGECAPRGRCDGEEDCADGSDERGCGWPCAPHHLPCANGPRCVAPAQLCDGV
PQCPDGSDESSDACGSTQLPPCGGLFPCGLAPQLCLNPERLCDGIPDCPQGEDELGCGWT
PDSPAGGQAGGRPGGGVTPQPTVLSLLFSPGGLLAPGGPNRTGVSCPEYSCPEGLCIVDG
EWTSWSPWSSCSEPCGGTMSRQRRCHPPQNGGRTCAMLPGGPHSTYQTRPCPQDDCPNAT
CSGELVFRPCAPCPLTCDDISGQAVCPPDRPCSSPGCWCPEGQVLDAEGRCVWPRKCPCL
VDGTRYWPGQQVKADCQLCICQDGRPRRCRPDPNCAVNCGWSSWSPWAECLGPCGSQSIQ
WSFRSPNNPRLSGRGRQCWGIHRKARRCQTGPCEGCAHQGQVRRVGERWRAGPCTVCQCL
HNGTARCSPYCPLGSCPQDWVLVEGLGESCCHCAPPGENQTVYPMATPTPTPAPSPQMGP
PLITYVLPPPGDPCYSPLGLAQLPEGSLRALPWQLEHPTWAARLGAPTDGPGHQGWSPRE
DAHSQQRTQPLYLQLDLLRPRTSLVSIIVPGAGSSDLLQFSSDGLHWYNYRDILPGAPLC
PQLFPGNWEDVGPTVRTFSRMVQAQHVRVWPHDAHHSDTHRSVSLRVELLGCEPVSPLEA
SPCPGGGHRCASGECAPRGAPCDGVEDCMDGSDEEGCVPPPGTGSIPSTARTPPLSSTQP
GQLPPQHREGLAETESWHPGQRSPVPPTGKGPARHLPTSEAPRLSPGKSVQTVVTTAPTR
QPEAEALQPGMAAVTVLPSDAMTPTAPAGQSVAPGPFPPVQCSPGQVPCEVVGCVDQEQL
CDEREDCLDGSDERHCGEHGATVPFTVPTTALPGLLASRALCSPSQLSCGSGECLPAERR
CDRHRDCQDGSDEDGCVDCGLAPWSGWSSCSRSCGLGLAFQRRELLWPPLPGGSCPPDRL
RSQPCFMQACPVAGAWAVWEAWGPCSVSCGGGHRSRRRSCVDPPPKNGGAPCPGTSQERA
PCGLQPCTGGTDCRAEPVRMIKDELCQKGLVSNPPPPLLPRTGAECPSPHTSGCRCPPGL
LLHDSHCLPLSQCPCLVGEELKQPGMPFLLDNCSQCTCEKGALLCEPGGCPVPCGWSAWS
SWGPCDRSCGSGVRARFRSPSNPPAASGGAPCEGDRQEVQVCHTECGTETLGWTPWAPWS
SCSRSCLAPGGGPGRRSRTRLCSSPGDTSCPGEATEEEPCSPAMCPGMPPVWGLWSPWST
CSAHCDGGIQTRGRSCSASAPGDSECQGPHSQTKDCNTQPCTAQCPGDMVFRSMEQCHQE
GGPCPRLCLAQGPGVECIGFCAPGCACPPGLFLHNASCLPPSRCPCQLHGQLYAPGEVAQ
LDSCNNCTCISGEMVCTSEPCPVACGWSPWTPWSVCSRSCNVGLRRRFRAGTAPPAAFGG
PACQGPDMEAEFCSLRPCQGPGGEWGPWSPCSVPCGGGYRNRTRGGGPHSLMDFSPCGLQ
PCAGPVPGVCPRGKRWLDCAEGPASCAELSAPQGTNQTCHPGCYCPSGTLLLNNVCVPSQ
DCPCAHGGRLHPPGSAVLRPCENCSCVSGLITNCTSWPCAEGQPTWSPWTPWSECSASCG
PARRHRHRFCTRRPGMVLSSMALLPPPASATPLCPGPEAEEEPCLLPGCDRAGGWGPWGP
WSSCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGETCQVLPCPVTNCTAIQGAEYS
RCGPPCPRSCDDLVHCVWHCQPGCYCPPGQVLSADQAICVQPGHCSCLDLLTGEWHRPGT
QLARPDGCNYCTCSEGRLTCTDLPCPVPGGWCPWSEWTACTQPCRSQMRTRSRACTCPPP
QHGGAPCPGEAGEAGAQHQRETCPSPTACPVDGAWSPWGPWSPCDTCLGQSHRSRVCSWP
PTEGGRPCPGGHRQSRPCQDNSTRCTDCGGGQELLPCGRPCPRSCQDLSLGMMCQPGSMA
CQPSCGCPPGQLSQDGLCVSPAHCRCQYQPGAMGIPENQSRSAGSGLSSWESLEPGEVVT
GPCDNCTCVAGILQCQEVPGCPGPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCLGPA
RQSRTCHTQVCREAGCPAGRLYRECQPSEGCPFSCAHITQQVGCFSDGCEEGCHCPEGTF
QHGSACVQECPCVLTALLLQELGAASADPEARPPILGEGGQPLGPGDELGSGQTLRVGCS
NCSCVHGKLSCSVEDCSRAGGGFSPWGPWGLCSRSCGGLGTRTRSRQCVYPTPAPGGQGC
LGPHQDLEYCPSPDCPGAGGSTVEPATGLPGGWGLWSPWSPCSSSCTDPARPALRSRTRL
CLVNCTSGDTSQERPCNLPSCTELPLCPGPGCVAGNCSWTTWAPWEPCSRSCGVGQQRRL
RAYRPPGPGGHWCPDILTAYQEHRFCNRRACPVPGGWSRWSPWSWCDRSCGGGRSLRSRR
CSSPPPKNGGAPCVGERHHARLCNPMPCEEGCPAGMEVVSCANRCPRRCSDLQEGIVCQD
GQPCQRGCRCPEGSLEQDSGCVPIEHCECTDAQGHSWAPGSQHQEACNNCSCQAGQLSCT
AQPCPPPSHCTWSRWSAWSPCSRSCGPGGQQSRFRSSTSDSWAPECREEQSQSQPCPQPP
CPPLCLHGAHSRTLGDSWQQGECQQCSCTPEGVICEDTKCAGLEPGAWTLWSPWSDCLVS
CGGGNQVRTRVCMALASRLEPRHCLGPDTQTQHCGWQPCPGLQEACSWGPWGPCSRSCGP
GLASRSGSCPCLLAEADPTCNGTFLHLDTQACYAGPCLEECVWSSWSSWTRCSCQVLVQQ
RYRHQGPAPGRAREGPPCTRLDGHFRPCLISNCSEDSCTPPFEFQACGSPCAGLCATHLS
RGLCQDLPPCQPGCYCPEGLLEQAGGCIPPEQCSCQHILGEGAGVTLAPGENLQLGCKEC
VCQHGELRCTSWGCQGLLPLSGWSEWSPCGPCLPLGVLAPASRAALEERWPQDPASLSPT
SAPVLASEQHRHRLCLDPETGRPWAGDPDLCTAPLSQQRLCPDPQACHDLCQWSPWGPWS
PCQVPCSGGFRLRWRKAGVPPGGGCRGPWAQTESCNMGPCPGESCESRDTVPTPDCANQC
PRSCADLWDRVQCLQGPCRPGCRCPPGQLVQDGHCVPISSCRCGLPSPNASWVLAPAEVV
QLDCKTCTCVNGSLLCPRHECPVLGPWSAWSSCSAPCGGGTTKRRRSCEEGPRGAPCQAQ
DTEQRQECNPQPCPECPPGQVLSACALSCPRLCSHLQPGDLCVQEPCQPGCGCPGGQLLH
NGTCVPPTACPCTQLSLPWGLTLSLEEQAQELPPGTVLSWNCTRCVCQGGAFNCSLADCQ
DCPPGEVWQQVAPGELGPCERTCWEPNATESQSNCSAGQAPGCVCQPGHFRSQAGPCVPA
DRCECWRHGHPHPPGSEWQEDCESCRCLGGRSVCTQQCPPLTCAQGEVTMQEPGSCCPTC
RQETLEEQSASCRHLTELRNLTKGPCYLDQVEVSYCSGHCPSSTNVMPEEPYLQSQCDCC
SYRLDPESPVRILNLRCPGGHTEPVVLPVIHSCQCSACQGGDFSKR
Download sequence
Identical sequences F6R3U6
ENSECAP00000015453

Jump to [ Top of page · Domain architecture · Domain assignment details · Most Informative Gene Ontologies ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.