The results are sorted from lowest E-value to highest E-value. Strong classifications have a low E-value. Weak classifications have an E-value greater than 0.0001. Weak hits are shown in gray. Weak hits are not shown on the domain architecture.
The family level classification is conditional on the domain being a member of the specified superfamily. There is a possibility that the selected domain is a member of a sub-family for which no structure has yet been solved.
| Sequence: |
ENSGGOP00000003730 |
| Domain Number 1 |
Region: 381-517 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Actin depolymerizing proteins |
2.57e-32 |
| Family |
Gelsolin-like |
0.00018 |
| Further Details: |
|
| |
| Domain Number 2 |
Region: 7-140 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Actin depolymerizing proteins |
3.97e-31 |
| Family |
Gelsolin-like |
0.0000685 |
| Further Details: |
|
| |
| Domain Number 3 |
Region: 605-716 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Actin depolymerizing proteins |
1.24e-27 |
| Family |
Gelsolin-like |
0.0001 |
| Further Details: |
|
| |
| Domain Number 4 |
Region: 498-600 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Actin depolymerizing proteins |
1.92e-25 |
| Family |
Gelsolin-like |
0.00048 |
| Further Details: |
|
| |
| Domain Number 5 |
Region: 238-427 |
| Classification Level |
Classification |
E-value |
| Superfamily |
C-terminal, gelsolin-like domain of Sec23/24 |
1.02e-21 |
| Family |
C-terminal, gelsolin-like domain of Sec23/24 |
0.01 |
| Further Details: |
|
| |
| Domain Number 6 |
Region: 116-224 |
| Classification Level |
Classification |
E-value |
| Superfamily |
C-terminal, gelsolin-like domain of Sec23/24 |
7.59e-21 |
| Family |
C-terminal, gelsolin-like domain of Sec23/24 |
0.015 |
| Further Details: |
|
| |
| Domain Number 7 |
Region: 781-855 |
| Classification Level |
Classification |
E-value |
| Superfamily |
VHP, Villin headpiece domain |
7.85e-21 |
| Family |
VHP, Villin headpiece domain |
0.0007 |
| Further Details: |
|
| |
The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by 
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Information Content (IC) is an information theoretic score measured in bits of how informative it is to assign a given ontological term to a domain archtecture. The higher the score the more informative it is to talk about the term given the domain architecture.
H-score (hypergeometric score) indicates the strength of assigning an ontological term to this domain architecture. Assignments with higher scores are of a better quality. Details for the methodology be found on the dcGO website.
| Molecular Function |
IC (bits) |
H-Score |
| Cellular Component |
IC (bits) |
H-Score |
| Biological Process |
IC (bits) |
H-Score |
