The results are sorted from lowest E-value to highest E-value. Strong classifications have a low E-value. Weak classifications have an E-value greater than 0.0001. Weak hits are shown in gray. Weak hits are not shown on the domain architecture.
The family level classification is conditional on the domain being a member of the specified superfamily. There is a possibility that the selected domain is a member of a sub-family for which no structure has yet been solved.
| Sequence: |
ENSTNIP00000022098 |
| Domain Number 1 |
Region: 930-1099,1147-1220,1288-1387 |
| Classification Level |
Classification |
E-value |
| Superfamily |
PLC-like phosphodiesterases |
7.21e-115 |
| Family |
Mammalian PLC |
0.00000437 |
| Further Details: |
|
| |
| Domain Number 2 |
Region: 1676-1781 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Ubiquitin-like |
4.96e-37 |
| Family |
Ras-binding domain, RBD |
0.00000992 |
| Further Details: |
|
| |
| Domain Number 3 |
Region: 79-278,306-368 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Ras GEF |
1.44e-35 |
| Family |
Ras GEF |
0.0055 |
| Further Details: |
|
| |
| Domain Number 4 |
Region: 1414-1524 |
| Classification Level |
Classification |
E-value |
| Superfamily |
C2 domain (Calcium/lipid-binding domain, CaLB) |
3.72e-21 |
| Family |
PLC-like (P variant) |
0.0029 |
| Further Details: |
|
| |
| Domain Number 5 |
Region: 1549-1653 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Ubiquitin-like |
3.88e-19 |
| Family |
Ras-binding domain, RBD |
0.00039 |
| Further Details: |
|
| |
| Domain Number 6 |
Region: 745-777,855-918 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EF-hand |
0.00000000000000129 |
| Family |
EF-hand modules in multidomain proteins |
0.025 |
| Further Details: |
|
| |
| Domain Number 7 |
Region: 415-553 |
| Classification Level |
Classification |
E-value |
| Superfamily |
PH domain-like |
0.0000307 |
| Family |
Pleckstrin-homology domain (PH domain) |
0.0069 |
| Further Details: |
|
| |
The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by 
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Information Content (IC) is an information theoretic score measured in bits of how informative it is to assign a given ontological term to a domain archtecture. The higher the score the more informative it is to talk about the term given the domain architecture.
H-score (hypergeometric score) indicates the strength of assigning an ontological term to this domain architecture. Assignments with higher scores are of a better quality. Details for the methodology be found on the dcGO website.
| Cellular Component |
IC (bits) |
H-Score |
| Molecular Function |
IC (bits) |
H-Score |
| Biological Process |
IC (bits) |
H-Score |
