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Domain assignment for E2ICL8 from Uniprot 2018_03 genome

Domain architecture


Domain assignment details

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Strong hits

Sequence:  E2ICL8
Domain Number 1 Region: 240-438
Classification Level Classification E-value
Superfamily Metalloproteases ("zincins"), catalytic domain 2.39e-47
Family Reprolysin-like 0.00028
Further Details:      
 
Domain Number 2 Region: 455-531
Classification Level Classification E-value
Superfamily Blood coagulation inhibitor (disintegrin) 1.99e-19
Family Blood coagulation inhibitor (disintegrin) 0.00048
Further Details:      
 
Weak hits

Sequence:  E2ICL8
Domain Number - Region: 677-715
Classification Level Classification E-value
Superfamily EGF/Laminin 0.00698
Family Integrin beta EGF-like domains 0.024
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Biological Process IC (bits) H-Score
Cellular Component IC (bits) H-Score
Molecular Function IC (bits) H-Score

Protein sequence

External link(s) E2ICL8
Sequence length 871
Comment (tr|E2ICL8|E2ICL8_XENTR) Metalloproteinase ADAM22 isoform 1 {ECO:0000313|EMBL:ADK56766.1} OX=8364 OS=Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). GN=adam22 OC=Silurana.
Sequence
MHIKGGRLASWICCVIGSIHLAHGSTRAGNGWMTGTQRKKENNVLGMEDTVPLRLIFTNE
VDNQTTQGLLSTRVRAGSPQHQDQLTHVARASFQIDAFGSSFILDVELNHDLLSSEYRER
HVTQDGKTVEFKGGEHCYYQGQIRGKAKSFVALSTCYGLHGMFCDGNHTYLIEPGEKYNP
NEDYQFHSVYKSKVLEFPIDELPSEFWPLNDTSPRLSQQTRNQRKKRQTRRYPRNVEDET
KYVELMIVNDHLMYKKHRLSVGHTNSYAKSVVNMADLIYKEQLNTRIVLVAMETWATDNK
FSISENPLLTLKEFMKYRRDFIKDKSDAVHLFSGSQFESSRSGAAYIGGVCSLLKGGGVN
EFGKPDVMAVTLAQSLAHNLGIFSDKKKLLSGECKCEDTWSGCIMGDIGYYLPSKFSVCN
IEEYHEFLNNGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGTIAECAVEGGECCKKCT
LTQDSECSDGLCCSDCKFNPKEMICREAVNDCDIPETCTGNSSQCPANIHKLDGYQCESM
QGLCFGGRCKTRERQCKYIWGEKVSAADKYCYEKLNIEGTEKGNCGRNKETWIQCNKQDV
LCGYLLCTNISSVPRLGELDGDVTTSSVVNQGKLYNCSGGHVKLDEDTDLGYVEDGTPCG
TGMMCLEHRCLPIDSFNFSTCLGSTNKICSGHGVCSNEVKCICDSFWTGDDCSNFLPYDG
IIKPDEGHRDEGVISTNIIIGAIAGTILVLALVLGITAWGYKNYRRERSNGLSHSWSERI
PDTKHVSDVCENGRPRSNSWQGNVSSSRKKLRGKRFRPRSNSTETLSPAKSPSSSTGSIA
SSRKYPYPMPPLPDEERKANKQSARLWETSI
Download sequence
Identical sequences E2ICL8
gi|301079073|gb|ADK56766| NP_001243156.1.99540

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