The results are sorted from lowest E-value to highest E-value. Strong classifications have a low E-value. Weak classifications have an E-value greater than 0.0001. Weak hits are shown in gray. Weak hits are not shown on the domain architecture.
The family level classification is conditional on the domain being a member of the specified superfamily. There is a possibility that the selected domain is a member of a sub-family for which no structure has yet been solved.
| Sequence: |
H3G127 |
| Domain Number 1 |
Region: 298-488,885-1058 |
| Classification Level |
Classification |
E-value |
| Superfamily |
PLC-like phosphodiesterases |
1.13e-105 |
| Family |
Mammalian PLC |
0.0000209 |
| Further Details: |
|
| |
| Domain Number 2 |
Region: 1077-1201 |
| Classification Level |
Classification |
E-value |
| Superfamily |
C2 domain (Calcium/lipid-binding domain, CaLB) |
1.31e-28 |
| Family |
PLC-like (P variant) |
0.0017 |
| Further Details: |
|
| |
| Domain Number 3 |
Region: 558-668 |
| Classification Level |
Classification |
E-value |
| Superfamily |
SH2 domain |
2.15e-23 |
| Family |
SH2 domain |
0.0007 |
| Further Details: |
|
| |
| Domain Number 4 |
Region: 658-769 |
| Classification Level |
Classification |
E-value |
| Superfamily |
SH2 domain |
3.5e-23 |
| Family |
SH2 domain |
0.00043 |
| Further Details: |
|
| |
| Domain Number 5 |
Region: 797-858 |
| Classification Level |
Classification |
E-value |
| Superfamily |
SH3-domain |
0.000000000000117 |
| Family |
SH3-domain |
0.0011 |
| Further Details: |
|
| |
| Domain Number 6 |
Region: 495-535,866-919 |
| Classification Level |
Classification |
E-value |
| Superfamily |
PH domain-like |
0.00000683 |
| Family |
Pleckstrin-homology domain (PH domain) |
0.0091 |
| Further Details: |
|
| |
The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by 
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Information Content (IC) is an information theoretic score measured in bits of how informative it is to assign a given ontological term to a domain archtecture. The higher the score the more informative it is to talk about the term given the domain architecture.
H-score (hypergeometric score) indicates the strength of assigning an ontological term to this domain architecture. Assignments with higher scores are of a better quality. Details for the methodology be found on the dcGO website.
| Cellular Component |
IC (bits) |
H-Score |
| Molecular Function |
IC (bits) |
H-Score |
| Biological Process |
IC (bits) |
H-Score |
