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Domain assignment for O00408 from Uniprot 2018_03 genome

Domain architecture


Domain assignment details

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Strong hits

Sequence:  O00408
Domain Number 1 Region: 581-937
Classification Level Classification E-value
Superfamily HD-domain/PDEase-like 1.32e-110
Family PDEase 0.00000222
Further Details:      
 
Domain Number 2 Region: 394-576
Classification Level Classification E-value
Superfamily GAF domain-like 5.67e-49
Family GAF domain 0.0000000626
Further Details:      
 
Domain Number 3 Region: 225-407
Classification Level Classification E-value
Superfamily GAF domain-like 1.24e-33
Family GAF domain 0.0000000179
Further Details:      
 
Domain Number 4 Region: 45-197
Classification Level Classification E-value
Superfamily GAF domain-like 0.000000196
Family GAF domain 0.02
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Molecular Function IC (bits) H-Score
Biological Process IC (bits) H-Score
Cellular Component IC (bits) H-Score

Protein sequence

External link(s) O00408
Sequence length 941
Comment (sp|O00408|PDE2A_HUMAN) Cyclic GMP-stimulated phosphodiesterase KW=Complete proteome; Reference proteome OX=9606 OS=Homo sapiens (Human). GN=PDE2A; OC=Catarrhini; Hominidae; Homo.
Sequence
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
Download sequence
Identical sequences H2R546 O00408
NP_002590.1.87134 NP_002590.1.92137 XP_001174746.2.37143 XP_003815718.1.60992 ENSP00000334910 9606.ENSP00000334910 ENSP00000334910 gi|4505657|ref|NP_002590.1| ENSP00000334910

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