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Domain assignment for O60494 from Uniprot 2018_03 genome
Domain architecture
Domain assignment details
(show help)
The results are sorted from lowest E-value to highest E-value. Strong classifications have a low E-value. Weak classifications have an E-value greater than 0.0001. Weak hits are shown in gray. Weak hits are not shown on the domain architecture.
The family level classification is conditional on the domain being a member of the specified superfamily. There is a possibility that the selected domain is a member of a sub-family for which no structure has yet been solved.
Strong hits
| Sequence: |
O60494 |
| Domain Number 1 |
Region: 932-1042 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
2.09e-37 |
| Family |
Spermadhesin, CUB domain |
0.0002 |
| Further Details: |
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| Domain Number 2 |
Region: 1390-1506 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
3.27e-36 |
| Family |
Spermadhesin, CUB domain |
0.00032 |
| Further Details: |
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| |
| Domain Number 3 |
Region: 3154-3279 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.57e-35 |
| Family |
Spermadhesin, CUB domain |
0.00043 |
| Further Details: |
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| Domain Number 4 |
Region: 589-701 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
7.46e-35 |
| Family |
Spermadhesin, CUB domain |
0.00061 |
| Further Details: |
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| |
| Domain Number 5 |
Region: 2688-2799 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
6.54e-34 |
| Family |
Spermadhesin, CUB domain |
0.00033 |
| Further Details: |
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| Domain Number 6 |
Region: 2227-2334 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
7.85e-34 |
| Family |
Spermadhesin, CUB domain |
0.00038 |
| Further Details: |
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| Domain Number 7 |
Region: 1169-1277 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
8.64e-34 |
| Family |
Spermadhesin, CUB domain |
0.00062 |
| Further Details: |
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| Domain Number 8 |
Region: 1738-1848 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.44e-33 |
| Family |
Spermadhesin, CUB domain |
0.00059 |
| Further Details: |
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| Domain Number 9 |
Region: 1625-1733 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
2.22e-33 |
| Family |
Spermadhesin, CUB domain |
0.00032 |
| Further Details: |
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| |
| Domain Number 10 |
Region: 3036-3148 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
2.36e-33 |
| Family |
Spermadhesin, CUB domain |
0.00026 |
| Further Details: |
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| Domain Number 11 |
Region: 3401-3506 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
4.58e-32 |
| Family |
Spermadhesin, CUB domain |
0.0005 |
| Further Details: |
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| |
| Domain Number 12 |
Region: 1053-1158 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.14e-31 |
| Family |
Spermadhesin, CUB domain |
0.00078 |
| Further Details: |
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| Domain Number 13 |
Region: 1509-1617 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.44e-31 |
| Family |
Spermadhesin, CUB domain |
0.0008 |
| Further Details: |
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| Domain Number 14 |
Region: 2451-2564 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.44e-31 |
| Family |
Spermadhesin, CUB domain |
0.0009 |
| Further Details: |
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| Domain Number 15 |
Region: 3510-3621 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
3.53e-30 |
| Family |
Spermadhesin, CUB domain |
0.001 |
| Further Details: |
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| Domain Number 16 |
Region: 2335-2447 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
6.67e-30 |
| Family |
Spermadhesin, CUB domain |
0.0005 |
| Further Details: |
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| |
| Domain Number 17 |
Region: 1857-1964 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.01e-29 |
| Family |
Spermadhesin, CUB domain |
0.00076 |
| Further Details: |
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| Domain Number 18 |
Region: 1990-2089 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
7.46e-29 |
| Family |
Spermadhesin, CUB domain |
0.00034 |
| Further Details: |
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| Domain Number 19 |
Region: 1278-1387 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.96e-28 |
| Family |
Spermadhesin, CUB domain |
0.00045 |
| Further Details: |
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| Domain Number 20 |
Region: 824-927 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.27e-27 |
| Family |
Spermadhesin, CUB domain |
0.0007 |
| Further Details: |
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| Domain Number 21 |
Region: 2091-2212 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
2.36e-27 |
| Family |
Spermadhesin, CUB domain |
0.00067 |
| Further Details: |
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| Domain Number 22 |
Region: 2570-2686 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
6.15e-26 |
| Family |
Spermadhesin, CUB domain |
0.001 |
| Further Details: |
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| Domain Number 23 |
Region: 2915-3037 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
2.36e-25 |
| Family |
Spermadhesin, CUB domain |
0.00067 |
| Further Details: |
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| Domain Number 24 |
Region: 469-585 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
4.97e-25 |
| Family |
Spermadhesin, CUB domain |
0.0023 |
| Further Details: |
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| |
| Domain Number 25 |
Region: 708-815 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.57e-24 |
| Family |
Spermadhesin, CUB domain |
0.0021 |
| Further Details: |
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| Domain Number 26 |
Region: 2804-2917 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
4.71e-21 |
| Family |
Spermadhesin, CUB domain |
0.00087 |
| Further Details: |
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| Domain Number 27 |
Region: 3285-3395 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Spermadhesin, CUB domain |
1.31e-18 |
| Family |
Spermadhesin, CUB domain |
0.004 |
| Further Details: |
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| Domain Number 28 |
Region: 133-175 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EGF/Laminin |
0.0000000000214 |
| Family |
EGF-type module |
0.0093 |
| Further Details: |
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| Domain Number 29 |
Region: 432-474 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EGF/Laminin |
0.000000000219 |
| Family |
EGF-type module |
0.007 |
| Further Details: |
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| Domain Number 30 |
Region: 392-434 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EGF/Laminin |
0.000000363 |
| Family |
EGF-type module |
0.019 |
| Further Details: |
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| Domain Number 31 |
Region: 130-267 |
| Classification Level |
Classification |
E-value |
| Superfamily |
Growth factor receptor domain |
0.000000675 |
| Family |
Growth factor receptor domain |
0.01 |
| Further Details: |
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| Domain Number 32 |
Region: 302-361 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EGF/Laminin |
0.000036 |
| Family |
EGF-type module |
0.016 |
| Further Details: |
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| Domain Number 33 |
Region: 266-306 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EGF/Laminin |
0.0000444 |
| Family |
EGF-type module |
0.019 |
| Further Details: |
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| Domain Number 34 |
Region: 353-392 |
| Classification Level |
Classification |
E-value |
| Superfamily |
EGF/Laminin |
0.0000525 |
| Family |
EGF-type module |
0.031 |
| Further Details: |
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Gene Ontology term assignment detailsThe top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by 
(show help)
Information Content (IC) is an information theoretic score measured in bits of how informative it is to assign a given ontological term to a domain archtecture. The higher the score the more informative it is to talk about the term given the domain architecture.
H-score (hypergeometric score) indicates the strength of assigning an ontological term to this domain architecture. Assignments with higher scores are of a better quality. Details for the methodology be found on the dcGO website.
| Molecular Function |
IC (bits) |
H-Score |
| Cellular Component |
IC (bits) |
H-Score |
| Biological Process |
IC (bits) |
H-Score |
Protein sequence
| External link(s) |
O60494 |
| Sequence length |
3623 |
| Comment |
(sp|O60494|CUBN_HUMAN) Intrinsic factor-vitamin B12 receptor KW=Complete proteome; Reference proteome OX=9606 OS=Homo sapiens (Human). GN=CUBN; OC=Catarrhini; Hominidae; Homo. |
| Sequence |
MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQN
IEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDL
ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGT
PLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE
PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG
YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC
HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC
DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG
INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS
SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGS
IKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPL
LGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELF
LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCG
NGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGER
TCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFIT
SVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTW
HILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSL
MLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITV
RTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLW
LKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHG
SAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLR
TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY
TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK
GFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY
HSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFN
ASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ
DSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQAC
GGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFV
EILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGG
TFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIRE
GNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTH
GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA
RLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGG
FLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIR
DGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADR
GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD
ICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGN
VYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYL
ELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRV
PGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDN
HTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSI
GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNS
PQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEG
NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA
DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVI
TSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPII
GQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPH
WPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLA
TGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQY
DNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCG
DEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN
DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN
VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYD
KNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGST
VPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPD
VPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASA
VPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKD
CTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFS
QNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWV
LVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSN
QVFIKFHADYARRPSAFRLTWDS
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| Download sequence |
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| Identical sequences |
O60494
gi|126091152|ref|NP_001072.2| ENSP00000367054 ENSP00000367064 9606.ENSP00000367064 NP_001072.2.87134 NP_001072.2.92137 ENSP00000367064 |
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