SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from Please contact us if you experience any problems.

DEATH domain superfamily models

A superfamily is represented by one or more models; usually there is more than one model representing the superfamily. Since each model is built to capture the whole superfamily, they are likely to be overlapping and sometimes are mostly overlapping or even redundant to each other. Also models often do not score their own seed sequence more highly than other sequences in the superfamily, so it is a mistake to think that the model represents the seed sequence.

All models are available for immediate download after obtaining a license by filling in a short online registration form. Licenses are free for academic and commercial purposes.

Plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed for each model by following the model ID link.

All 18 SUPERFAMILY models representing the DEATH domain superfamily
Model ID No. of seqs Build date Seed sequence Family of seed
0038970 152 2005-09-08 d1icha_ DEATH domain, DD
0050656 418 2008-09-10 d1wmga_ DEATH domain, DD
0037465 166 2005-09-08 d1fada_ DEATH domain, DD
0046261 193 2008-09-10 d1d2za_ DEATH domain, DD
0036368 107 2005-09-08 d1ddfa_ DEATH domain, DD
0041381 175 2005-09-08 d1ngra_ DEATH domain, DD
0050544 228 2008-09-10 d1wh4a_ DEATH domain, DD
0036756 193 2005-09-08 d1e41a_ DEATH domain, DD
0036251 15 2005-09-08 d1d2zb_ DEATH domain, DD
0036420 147 2005-09-08 d1dgna_ Caspase recruitment domain, CARD
0045580 92 2005-09-08 d3ygsp_ Caspase recruitment domain, CARD
0036193 95 2005-09-08 d1cy5a_ Caspase recruitment domain, CARD
0045502 125 2005-09-08 d3crda_ Caspase recruitment domain, CARD
0053685 63 2010-05-31 d2a5yb2 Caspase recruitment domain, CARD
0048274 81 2008-09-10 d1n3ka_ DEATH effector domain, DED
0045697 398 2008-09-10 d1a1za_ DEATH effector domain, DED
0042393 98 2005-09-08 d1pn5a1 Pyrin domain, PYD
0044274 104 2005-09-08 d1ucpa_ Pyrin domain, PYD