SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.

Cystine-knot cytokines superfamily models

A superfamily is represented by one or more models; usually there is more than one model representing the superfamily. Since each model is built to capture the whole superfamily, they are likely to be overlapping and sometimes are mostly overlapping or even redundant to each other. Also models often do not score their own seed sequence more highly than other sequences in the superfamily, so it is a mistake to think that the model represents the seed sequence.

All models are available for immediate download after obtaining a license by filling in a short online registration form. Licenses are free for academic and commercial purposes.

Plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed for each model by following the model ID link.


All 23 SUPERFAMILY models representing the Cystine-knot cytokines superfamily
Model ID No. of seqs Build date Seed sequence Family of seed
0050683 444 2008-09-10 d1wq8a_ Platelet-derived growth factor-like
0037865 379 2005-09-08 d1fzva_ Platelet-derived growth factor-like
0042265 124 2005-09-08 d1pdga_ Platelet-derived growth factor-like
0046809 443 2008-09-10 d1fltv_ Platelet-derived growth factor-like
0050684 441 2008-09-10 d1wq9a_ Platelet-derived growth factor-like
0035043 236 2005-09-08 d1agqa_ Transforming growth factor (TGF)-beta
0040782 473 2005-09-08 d1m4ul_ Transforming growth factor (TGF)-beta
0047829 590 2008-09-10 d1klaa_ Transforming growth factor (TGF)-beta
0049623 591 2008-09-10 d1tgja_ Transforming growth factor (TGF)-beta
0045468 425 2005-09-08 d2tgia_ Transforming growth factor (TGF)-beta
0037154 464 2005-09-08 d1es7a_ Transforming growth factor (TGF)-beta
0041636 457 2005-09-08 d1nysb_ Transforming growth factor (TGF)-beta
0045943 97 2008-09-10 d1beta_ Neurotrophin
0045009 67 2005-09-08 d1wwwv_ Neurotrophin
0035633 70 2005-09-08 d1bndb_ Neurotrophin
0035632 72 2005-09-08 d1bnda_ Neurotrophin
0038527 67 2005-09-08 d1hcfa_ Neurotrophin
0038532 136 2005-09-08 d1hcnb_ Gonadodropin/Follitropin
0038531 33 2005-09-08 d1hcna_ Gonadodropin/Follitropin
0037644 134 2005-09-08 d1fl7b_ Gonadodropin/Follitropin
0045796 96 2008-09-10 d1aoca_ Coagulogen
0039692 50 2005-09-08 d1jpya_ Interleukin 17F, IL-17F
0048086 48 2008-09-10 d1m4ua_ Noggin