|
|
Disease Ontology (DO): organ system cancer
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: DO Hierarchy (disease ontology from University of Maryland)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this DO term (SDDO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| Bee venom hyaluronidase | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| SH2 domain | 0.0001081 | DIRECT |
| Protein kinases, catalytic subunit | 0.0002171 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.0004907 | DIRECT |
| S100 proteins | 0.0004907 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0.00267 | INHERITED FROM: skin carcinoma || basal cell carcinoma || breast carcinoma |
| Leucine zipper domain | 0.005332 | INHERITED FROM: hematologic cancer |
| Growth factor receptor domain | 0.005651 | INHERITED FROM: colorectal cancer || osteosarcoma || lung cancer || neurofibroma || ovary epithelial cancer || peripheral nerve sheath neoplasm || urinary system cancer || rhabdomyosarcoma || skeletal muscle cancer || liver carcinoma || kidney cancer || lung carcinoma || large intestine cancer |
| MMP N-terminal domain | 0.006323 | INHERITED FROM: oral cavity cancer || renal cell carcinoma || renal carcinoma || integumentary system cancer || breast cancer || head and neck squamous cell carcinoma || pancreatic ductal adenocarcinoma || endometrial carcinoma || myeloid neoplasm || chondrosarcoma || ovary epithelial cancer || reproductive organ cancer || prostate cancer || endometrial cancer || liver carcinoma || bile duct adenocarcinoma || kidney cancer || salivary gland adenoid cystic carcinoma || ovarian cancer |
| ABC transporter transmembrane region | 0.006323 | INHERITED FROM: acute myeloid leukemia || myeloid leukemia |
| TNF receptor-like | 0.006323 | INHERITED FROM: breast cancer || breast carcinoma || hematologic cancer || myeloid neoplasm || immune system cancer || pancreatic cancer || pancreatic adenocarcinoma |
| Cyclin | 0.008882 | INHERITED FROM: laryngeal carcinoma || retinal cell cancer || sensory system cancer || retinal cancer || larynx cancer |
| Pointed domain | 0.01337 | INHERITED FROM: breast cancer |
| Ephrin ectodomain | 0.01337 | INHERITED FROM: osteosarcoma || bone cancer |
| PB1 domain | 0.01337 | INHERITED FROM: breast cancer |
| Fibronectin type II module | 0.01527 | INHERITED FROM: thymoma || laryngeal carcinoma || thymus cancer || thyroid carcinoma || osteosarcoma || head and neck squamous cell carcinoma || bone cancer || myeloid neoplasm || Hodgkin's lymphoma || thyroid cancer || connective tissue cancer |
| Nuclear receptor ligand-binding domain | 0.0184 | INHERITED FROM: adrenocortical carcinoma || adrenal cortex cancer || breast lobular carcinoma || hereditary Wilms' tumor || endometrial carcinoma || reproductive organ cancer || endometrial cancer |
| HLH, helix-loop-helix DNA-binding domain | 0.01848 | INHERITED FROM: autonomic nervous system neoplasm |
| Hemopexin-like domain | 0.02074 | INHERITED FROM: bone marrow cancer || integumentary system cancer || meningioma || endometrial carcinoma || myeloid neoplasm || chondrosarcoma || ovary epithelial cancer || reproductive organ cancer || prostate cancer || endometrial cancer || salivary gland adenoid cystic carcinoma || ovarian cancer |
| Interleukin 8-like chemokines | 0.02529 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| A DNA-binding domain in eukaryotic transcription factors | 0.02649 | INHERITED FROM: hematologic cancer || immune system cancer |
| Nuclear receptor | 0.02782 | INHERITED FROM: thyroid carcinoma || breast lobular carcinoma || endometrial carcinoma || reproductive organ cancer || endometrial cancer |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.03238 | INHERITED FROM: hematologic cancer || leukemia || bile duct adenocarcinoma || bile duct cancer |
| Long-chain cytokines | 0.04468 | INHERITED FROM: thoracic cancer || breast cancer || female reproductive organ cancer |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.04468 | INHERITED FROM: colon cancer |
| Notch domain | 0.04754 | INHERITED FROM: renal cell carcinoma || renal carcinoma || urinary system cancer || lymphoblastic leukemia || liver carcinoma || kidney cancer || liver cancer |
| Matrix metalloproteases, catalytic domain | 0.057 | INHERITED FROM: oral cavity cancer || renal cell carcinoma || renal carcinoma || integumentary system cancer || head and neck squamous cell carcinoma || endometrial carcinoma || myeloid neoplasm || chondrosarcoma || ovary epithelial cancer || reproductive organ cancer || prostate cancer || endometrial cancer || bile duct adenocarcinoma || kidney cancer || salivary gland adenoid cystic carcinoma || ovarian cancer |
| Frizzled cysteine-rich domain | 0.06379 | INHERITED FROM: myeloid neoplasm || multiple myeloma || myeloid leukemia |
| MHC antigen-recognition domain | 0.07263 | INHERITED FROM: chronic myeloid leukemia || leukemia |
| STAT | 0.07959 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck carcinoma || head and neck cancer |
| Transcription factor STAT-4 N-domain | 0.07959 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck carcinoma || head and neck cancer |
| STAT DNA-binding domain | 0.07959 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck carcinoma || head and neck cancer |
| UDPGT-like | 0.08532 | INHERITED FROM: colorectal cancer || large intestine cancer |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.08532 | INHERITED FROM: nasopharynx carcinoma || colon cancer |
| Platelet-derived growth factor-like | 0.08532 | INHERITED FROM: thyroid carcinoma || osteosarcoma || lung cancer || non-small cell lung carcinoma || nasopharynx carcinoma || follicular thyroid carcinoma || thyroid cancer || papillary thyroid carcinoma || biliary tract cancer || liver carcinoma || bile duct adenocarcinoma || lung carcinoma || connective tissue cancer |
| Nucleoside diphosphate kinase, NDK | 0.08956 | INHERITED FROM: myeloid leukemia |
| Kringle modules | 0.0902 | INHERITED FROM: invasive ductal carcinoma || pancreatic ductal adenocarcinoma |
| FHA domain | 0.0902 | INHERITED FROM: retinal cell cancer || retinal cancer |
| Inhibitor of apoptosis (IAP) repeat | 0.1178 | INHERITED FROM: hematologic cancer || leukemia || ovary epithelial cancer || immune system cancer || ovarian cancer |
| DPP6 N-terminal domain-like | 0.1342 | INHERITED FROM: meningioma || central nervous system cancer || nervous system cancer || chronic lymphocytic leukemia |
| Fatty acid binding protein-like | 0.1422 | INHERITED FROM: renal cell carcinoma |
| DNA gyrase/MutL, second domain | 0.163 | INHERITED FROM: colorectal cancer || male reproductive organ cancer || intestinal cancer || large intestine cancer |
| DNA gyrase/MutL, N-terminal domain | 0.163 | INHERITED FROM: colorectal cancer || male reproductive organ cancer || intestinal cancer || large intestine cancer |
| Defensin | 0.163 | INHERITED FROM: non-Hodgkin lymphoma || mature T-cell and NK-cell lymphoma || mycosis fungoides |
| Reprolysin-like | 0.1696 | INHERITED FROM: breast carcinoma |
| C1 set domains (antibody constant domain-like) | 0.1708 | INHERITED FROM: leukemia || chronic leukemia |
| Eukaryotic proteases | 0.1848 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Thyroglobulin type-1 domain | 0.1859 | INHERITED FROM: renal cell carcinoma || renal carcinoma || retinal cell cancer || retinal cancer || kidney cancer |
| DPP6 catalytic domain-like | 0.2236 | INHERITED FROM: meningioma || central nervous system cancer |
| DNA repair protein MutS, domain III | 0.2236 | INHERITED FROM: urinary system cancer |
| NADPH-cytochrome p450 reductase-like | 0.2245 | INHERITED FROM: nervous system cancer || autonomic nervous system neoplasm |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.2245 | INHERITED FROM: nervous system cancer || autonomic nervous system neoplasm |
| SOCS box-like | 0.2371 | INHERITED FROM: chronic myeloid leukemia |
| C2 set domains | 0.2371 | INHERITED FROM: hematologic cancer || immune system cancer |
| Integrin domains | 0.2441 | INHERITED FROM: breast cancer || multiple myeloma |
| TSP-1 type 1 repeat | 0.285 | INHERITED FROM: neurofibroma || peripheral nerve sheath neoplasm |
| Paired domain | 0.3044 | INHERITED FROM: alveolar rhabdomyosarcoma || rhabdomyosarcoma || skeletal muscle cancer |
| Uteroglobin-like | 0.3086 | INHERITED FROM: thoracic cancer || breast cancer || breast carcinoma |
| Cytochrome p450 reductase N-terminal domain-like | 0.3086 | INHERITED FROM: peripheral nervous system neoplasm || nervous system cancer || autonomic nervous system neoplasm |
| Transforming growth factor (TGF)-beta | 0.3275 | INHERITED FROM: basal cell carcinoma || reproductive organ cancer || prostate cancer |
| SAM (sterile alpha motif) domain | 0.3758 | INHERITED FROM: invasive ductal carcinoma || endocrine gland cancer |
| Interleukin-1 (IL-1) | 0.3783 | INHERITED FROM: multiple myeloma || pancreatic cancer |
| Ankyrin repeat | 0.3955 | INHERITED FROM: rhabdomyosarcoma || skeletal muscle cancer |
| ABC transporter ATPase domain-like | 0.4139 | INHERITED FROM: acute myeloid leukemia || myeloid leukemia |
| Histone deacetylase, HDAC | 0.4216 | INHERITED FROM: Hodgkin's lymphoma || lymphoma |
| Intermediate filament protein, coiled coil region | 0.437 | INHERITED FROM: lung large cell carcinoma || pulmonary large cell neuroendocrine carcinoma |
| EGF-type module | 0.4452 | INHERITED FROM: histiocytoma |
| I set domains | 0.4727 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| Integrin beta tail domain | 0.4774 | INHERITED FROM: osteosarcoma || bone cancer || connective tissue cancer |
| Integrin beta EGF-like domains | 0.4774 | INHERITED FROM: osteosarcoma || bone cancer || connective tissue cancer |
| PDEase | 0.479 | INHERITED FROM: lymphoblastic leukemia || chronic lymphocytic leukemia |
| TNF-like | 0.5504 | INHERITED FROM: Burkitt lymphoma || B-cell lymphoma || myeloid neoplasm |
| Ras-binding domain, RBD | 0.6627 | INHERITED FROM: head and neck squamous cell carcinoma || head and neck carcinoma |
| Ran binding protein zinc finger-like | 0.747 | INHERITED FROM: retinal cell cancer || sensory system cancer || retinal cancer |
| Second domain of FERM | 0.8764 | INHERITED FROM: meningioma |
| Toll/Interleukin receptor TIR domain | 0.8942 | INHERITED FROM: mature T-cell and NK-cell lymphoma || mycosis fungoides |
| First domain of FERM | 0.9162 | INHERITED FROM: meningioma |
| Third domain of FERM | 0.9908 | INHERITED FROM: meningioma |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Ephrin receptor ligand binding domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| DNA ligase | 0 | Direct |
| Bee venom hyaluronidase | 0 | Direct |
| L domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| PA domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| SH2 domain | 0.0001081 | Direct |
| Protein kinases, catalytic subunit | 0.0002171 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.0004907 | Direct |
| S100 proteins | 0.0004907 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0.00267 | Inherited |
| Leucine zipper domain | 0.005332 | Inherited |
| Growth factor receptor domain | 0.005651 | Inherited |
| MMP N-terminal domain | 0.006323 | Inherited |
| ABC transporter transmembrane region | 0.006323 | Inherited |
| TNF receptor-like | 0.006323 | Inherited |
| Cyclin | 0.008882 | Inherited |
| Pointed domain | 0.01337 | Inherited |
| Ephrin ectodomain | 0.01337 | Inherited |
| PB1 domain | 0.01337 | Inherited |
| Fibronectin type II module | 0.01527 | Inherited |
| Nuclear receptor ligand-binding domain | 0.0184 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01848 | Inherited |
| Hemopexin-like domain | 0.02074 | Inherited |
| Interleukin 8-like chemokines | 0.02529 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.02649 | Inherited |
| Nuclear receptor | 0.02782 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.03238 | Inherited |
| Long-chain cytokines | 0.04468 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.04468 | Inherited |
| Notch domain | 0.04754 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.057 | Inherited |
| Frizzled cysteine-rich domain | 0.06379 | Inherited |
| MHC antigen-recognition domain | 0.07263 | Inherited |
| STAT | 0.07959 | Inherited |
| Transcription factor STAT-4 N-domain | 0.07959 | Inherited |
| STAT DNA-binding domain | 0.07959 | Inherited |
| UDPGT-like | 0.08532 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.08532 | Inherited |
| Platelet-derived growth factor-like | 0.08532 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.08956 | Inherited |
| Kringle modules | 0.0902 | Inherited |
| FHA domain | 0.0902 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.1178 | Inherited |
| DPP6 N-terminal domain-like | 0.1342 | Inherited |
| Fatty acid binding protein-like | 0.1422 | Inherited |
| DNA gyrase/MutL, second domain | 0.163 | Inherited |
| DNA gyrase/MutL, N-terminal domain | 0.163 | Inherited |
| Defensin | 0.163 | Inherited |
| Reprolysin-like | 0.1696 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.1708 | Inherited |
| Eukaryotic proteases | 0.1848 | Inherited |
| Thyroglobulin type-1 domain | 0.1859 | Inherited |
| DPP6 catalytic domain-like | 0.2236 | Inherited |
| DNA repair protein MutS, domain III | 0.2236 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.2245 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.2245 | Inherited |
| SOCS box-like | 0.2371 | Inherited |
| C2 set domains | 0.2371 | Inherited |
| Integrin domains | 0.2441 | Inherited |
| TSP-1 type 1 repeat | 0.285 | Inherited |
| Paired domain | 0.3044 | Inherited |
| Uteroglobin-like | 0.3086 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.3086 | Inherited |
| Transforming growth factor (TGF)-beta | 0.3275 | Inherited |
| SAM (sterile alpha motif) domain | 0.3758 | Inherited |
| Interleukin-1 (IL-1) | 0.3783 | Inherited |
| Ankyrin repeat | 0.3955 | Inherited |
| ABC transporter ATPase domain-like | 0.4139 | Inherited |
| Histone deacetylase, HDAC | 0.4216 | Inherited |
| Intermediate filament protein, coiled coil region | 0.437 | Inherited |
| EGF-type module | 0.4452 | Inherited |
| I set domains | 0.4727 | Inherited |
| Integrin beta tail domain | 0.4774 | Inherited |
| Integrin beta EGF-like domains | 0.4774 | Inherited |
| PDEase | 0.479 | Inherited |
| TNF-like | 0.5504 | Inherited |
| Ras-binding domain, RBD | 0.6627 | Inherited |
| Ran binding protein zinc finger-like | 0.747 | Inherited |
| Second domain of FERM | 0.8764 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.8942 | Inherited |
| First domain of FERM | 0.9162 | Inherited |
| Third domain of FERM | 0.9908 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this DO term (SPDO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.002221 | INHERITED FROM: breast carcinoma || skin carcinoma || basal cell carcinoma |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.005464 | INHERITED FROM: myeloid neoplasm || breast cancer || breast carcinoma || hematologic cancer || liver carcinoma || immune system cancer || pancreatic adenocarcinoma |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.005464 | INHERITED FROM: reproductive organ cancer || prostate cancer || myeloid neoplasm || ovary epithelial cancer || connective tissue cancer || breast cancer || salivary gland adenoid cystic carcinoma || chondrosarcoma || renal carcinoma || endometrial carcinoma || ovarian cancer || renal cell carcinoma || liver carcinoma || kidney cancer || integumentary system cancer || oral cavity cancer || head and neck squamous cell carcinoma || endometrial cancer || pancreatic ductal adenocarcinoma || bile duct adenocarcinoma |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.006122 | INHERITED FROM: invasive ductal carcinoma || pancreatic cancer || breast carcinoma || hematologic cancer || leukemia || pancreatic adenocarcinoma |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.007724 | INHERITED FROM: endometrial carcinoma || thyroid carcinoma || endometrial cancer || thyroid cancer |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01232 | INHERITED FROM: fibrosarcoma of bone || endometrial stromal sarcoma || immune system cancer |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.01493 | INHERITED FROM: laryngeal carcinoma || nasopharynx carcinoma || sensory system cancer || hematologic cancer || retinal cancer || retinal cell cancer |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.02371 | INHERITED FROM: hematologic cancer || immune system cancer |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0.04059 | INHERITED FROM: invasive ductal carcinoma || breast cancer || pancreatic cancer || breast carcinoma || pancreatic ductal adenocarcinoma |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.04166 | INHERITED FROM: lung large cell carcinoma || pulmonary large cell neuroendocrine carcinoma |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.04303 | INHERITED FROM: reproductive organ cancer || prostate cancer || prostate carcinoma || chondrosarcoma |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05218 | INHERITED FROM: acute myeloid leukemia || myeloid leukemia |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.05674 | INHERITED FROM: invasive ductal carcinoma || prostate cancer || myeloid neoplasm || connective tissue cancer || acute myeloid leukemia || endocrine gland cancer || breast carcinoma || bone cancer || male reproductive organ cancer || nasopharynx carcinoma || head and neck carcinoma || thyroid carcinoma || Hodgkin's lymphoma || lung cancer || head and neck squamous cell carcinoma || pancreatic adenocarcinoma || pancreatic ductal adenocarcinoma || lung carcinoma || osteosarcoma |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.06042 | INHERITED FROM: immune system cancer |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.07298 | INHERITED FROM: head and neck carcinoma || chronic leukemia || head and neck cancer || chronic myeloid leukemia |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07298 | INHERITED FROM: head and neck carcinoma || chronic leukemia || head and neck cancer || chronic myeloid leukemia |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.07298 | INHERITED FROM: head and neck carcinoma || chronic leukemia || head and neck cancer || chronic myeloid leukemia |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.07902 | INHERITED FROM: nasopharynx carcinoma || colon cancer |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.07902 | INHERITED FROM: invasive ductal carcinoma || breast ductal carcinoma || pancreatic cancer || pancreatic adenocarcinoma || pancreatic ductal adenocarcinoma |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.08074 | INHERITED FROM: nasopharynx carcinoma || leukemia |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0.08357 | INHERITED FROM: breast cancer || breast carcinoma || thoracic cancer |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0.1244 | INHERITED FROM: lymphoblastic leukemia || chronic lymphocytic leukemia || central nervous system cancer || nervous system cancer || meningioma |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1435 | INHERITED FROM: renal carcinoma || renal cell carcinoma || kidney cancer |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.1523 | INHERITED FROM: acute myeloid leukemia || hematologic cancer || leukemia || immune system cancer |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.1523 | INHERITED FROM: renal carcinoma || renal cell carcinoma || kidney cancer || urinary system cancer |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2082 | INHERITED FROM: urinary system cancer |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.2105 | INHERITED FROM: lymphoblastic leukemia || renal carcinoma || bone marrow cancer || renal cell carcinoma || kidney cancer |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.2894 | INHERITED FROM: myeloid neoplasm || bone marrow cancer |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0.2894 | INHERITED FROM: myeloid leukemia |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.3556 | INHERITED FROM: male reproductive organ cancer |
81296,81296
81296 - E set domains
81296 - E set domains | 0.3556 | INHERITED FROM: prostate cancer || male reproductive organ cancer |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.4472 | INHERITED FROM: chronic myeloid leukemia |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.4472 | INHERITED FROM: connective tissue cancer || bone cancer || osteosarcoma |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.5556 | INHERITED FROM: myeloid neoplasm || bone marrow cancer |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.9387 | INHERITED FROM: meningioma |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.9489 | INHERITED FROM: meningioma |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.002221 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.005464 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.005464 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.006122 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.007724 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01232 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.01493 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.02371 | Inherited |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0.04059 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.04166 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.04303 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05218 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.05674 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.06042 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.07298 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07298 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.07298 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.07902 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.07902 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.08074 | Inherited |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0.08357 | Inherited |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0.1244 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1435 | Inherited |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.1523 | Inherited |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.1523 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2082 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.2105 | Inherited |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.2894 | Inherited |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0.2894 | Inherited |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.3556 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.3556 | Inherited |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.4472 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.4472 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.5556 | Inherited |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.9387 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.9489 | Inherited |
(show details)
Supra-domains annotated to this DO term (SPDO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01493 | INHERITED FROM: reproductive organ cancer || prostate cancer || ovary epithelial cancer || prostate carcinoma || chondrosarcoma |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.07298 | INHERITED FROM: head and neck carcinoma || chronic leukemia || head and neck cancer || chronic myeloid leukemia |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07298 | INHERITED FROM: head and neck carcinoma || chronic leukemia || head and neck cancer || chronic myeloid leukemia |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.07902 | INHERITED FROM: renal carcinoma || renal cell carcinoma || kidney cancer |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.07902 | INHERITED FROM: invasive ductal carcinoma || pancreatic cancer || breast carcinoma || hematologic cancer || leukemia || pancreatic adenocarcinoma || pancreatic ductal adenocarcinoma |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0.08357 | INHERITED FROM: breast cancer || breast carcinoma || thoracic cancer |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.1523 | INHERITED FROM: prostate cancer || myeloid neoplasm || connective tissue cancer || acute myeloid leukemia || bone cancer || lymphoblastic leukemia || male reproductive organ cancer || nasopharynx carcinoma || colorectal cancer || bone marrow cancer || head and neck carcinoma || peripheral nervous system neoplasm || gastrointestinal system cancer || large intestine cancer || autonomic nervous system neoplasm || Hodgkin's lymphoma || head and neck squamous cell carcinoma || lymphoma || osteosarcoma |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.1692 | INHERITED FROM: breast cancer |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1789 | INHERITED FROM: fibrosarcoma of bone |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.2894 | INHERITED FROM: myeloid neoplasm || bone marrow cancer |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.2894 | INHERITED FROM: myeloid leukemia |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2894 | INHERITED FROM: myeloid neoplasm || bone marrow cancer |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2945 | INHERITED FROM: renal carcinoma |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.4472 | INHERITED FROM: connective tissue cancer || bone cancer || osteosarcoma |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.468 | INHERITED FROM: breast carcinoma |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.9387 | INHERITED FROM: meningioma |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01493 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.07298 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07298 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.07902 | Inherited |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.07902 | Inherited |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0.08357 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.1523 | Inherited |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.1692 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1789 | Inherited |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.2894 | Inherited |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.2894 | Inherited |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2894 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2945 | Inherited |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.4472 | Inherited |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.468 | Inherited |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.9387 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
