SUPERFAMILY 1.75 HMM library and genome assignments server

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Disease Ontology (DO): integumentary system cancer

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + 2:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ 1:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
0:   integumentary system cancer [DOID:0060122] <1>(4|5) (6|2|0)
- 1:   skin cancer [DOID:4159] <8>(1|2) (3|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Metalloproteases ("zincins"), catalytic domain0.00009716Direct
PGBD-like0.0002444Direct
Hemopexin-like domain0.0003572Direct
Blood coagulation inhibitor (disintegrin)0.005464Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
MMP N-terminal domain0.0001733Direct
Hemopexin-like domain0.0002515Direct
Matrix metalloproteases, catalytic domain0.0002515Direct
Blood coagulation inhibitor (disintegrin)0.003991Inherited
Transforming growth factor (TGF)-beta0.01935Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Metalloproteases ("zincins"), catalytic domain0.00005701Direct
PGBD-like0.0001473Direct
Hemopexin-like domain0.0002167Direct
Blood coagulation inhibitor (disintegrin)0.003726Inherited
Cystine-knot cytokines0.03024Inherited
EF-hand0.2295Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0001473Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.003726Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)