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Disease Ontology (DO): hypertension

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   disease [DOID:4] <8>
+ + + + 4:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + + 3:   cardiovascular system disease [DOID:1287] <3>(41|53) (41|24|14)
+ + 2:   vascular disease [DOID:178] <13>(37|48) (38|22|11)
+ 1:   artery disease [DOID:0050828] <12>(29|34) (31|15|8)
0:   hypertension [DOID:10763] <5>(8|12) (9|2|0)
- 1:   pre-eclampsia [DOID:10591] <3>(3|6) (4|0|0)
- 1:   secondary hypertension [DOID:11130] <3>(0|0) (0|0|0)
- 1:   essential hypertension [DOID:10825] <2>(0|0) (0|0|0)
- 1:   malignant hypertension [DOID:10824] <2>(0|0) (0|0|0)
- 1:   pulmonary hypertension [DOID:6432] <2>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Insulin-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Leukotriene A4 hydrolase N-terminal domain0.000007425Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0006238Direct
Riboflavin synthase domain-like0.0006238Direct
Somatomedin B domain0.002039Inherited
Flavoproteins0.2892Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Insulin-like0Direct
Leukotriene A4 hydrolase catalytic domain0.000006117Direct
Leukotriene A4 hydrolase N-terminal domain0.00005558Direct
Transforming growth factor (TGF)-beta0.0001539Direct
Short-chain cytokines0.0003265Direct
Cytochrome p450 reductase N-terminal domain-like0.00045Direct
Somatomedin B domain0.001636Inherited
NADPH-cytochrome p450 reductase-like0.001636Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001636Inherited
Serpins0.5798Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Insulin-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Leukotriene A4 hydrolase N-terminal domain0.000004036Direct
Riboflavin synthase domain-like0.0003835Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0003835Direct
Somatomedin B domain0.001326Inherited
Flavoproteins0.2454Inherited
Serpins0.5522Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63737,55486
  • 63737 - Leukotriene A4 hydrolase N-terminal domain
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.000004036Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.00003962Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)