Disease Ontology (DO): cardiovascular system disease

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: disease [DOID:4] <8>

+ 1: disease of anatomical entity [DOID:7] <12> (143|187) (147|103|58)

0: cardiovascular system disease [DOID:1287] <3> (41|53) (41|24|14)

- 1: vascular disease [DOID:178] <13> (37|48) (38|22|11)

- 1: heart disease [DOID:114] <8> (8|11) (9|5|4)

- 1: pericardium disease [DOID:0050829] <2> (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Apolipoprotein A-I	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Insulin-like	0	Direct
Fibrinogen coiled-coil and central regions	0	Direct
Anaphylotoxins (complement system)	0	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.00002301	Direct
Cytochrome P450	0.00003308	Direct
Metalloproteases ("zincins"), catalytic domain	0.0001778	Direct
YWTD domain	0.0008098	Direct
FnI-like domain	0.0009291	Direct
Kringle-like	0.001738	Inherited
PGBD-like	0.001907	Inherited
GLA-domain	0.002226	Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain	0.002906	Inherited
Blood coagulation inhibitor (disintegrin)	0.00514	Inherited
EGF/Laminin	0.006633	Inherited
Leukotriene A4 hydrolase N-terminal domain	0.007129	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.007359	Inherited
Riboflavin synthase domain-like	0.007359	Inherited
Hemopexin-like domain	0.007729	Inherited
Snake toxin-like	0.00778	Inherited
Serpins	0.01315	Inherited
TIMP-like	0.01474	Inherited
Troponin coil-coiled subunits	0.01716	Inherited
Flavoproteins	0.02433	Inherited
Hairpin loop containing domain-like	0.04026	Inherited
TSP type-3 repeat	0.04026	Inherited
Calcium-dependent phosphotriesterase	0.04026	Inherited
MAPEG domain-like	0.04026	Inherited
Phospholipase A2, PLA2	0.04026	Inherited
Nuclear receptor ligand-binding domain	0.04552	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.05153	Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)	0.05313	Inherited
TNF-like	0.05604	Inherited
Myosin rod fragments	0.0699	Inherited
TNF receptor-like	0.07165	Inherited
Somatomedin B domain	0.1069	Inherited
Cytokine	0.1447	Inherited
MHC antigen-recognition domain	0.2702	Inherited
Voltage-gated potassium channels	0.515	Inherited
RNA-binding domain, RBD	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Tissue inhibitor of metalloproteinases, TIMP	0	Direct
Serum paraoxonase/arylesterase 1, PON1	0	Direct
Insulin-like	0	Direct
Netrin-like domain (NTR/C345C module)	0	Direct
Multidomain cupredoxins	0	Direct
Apolipoprotein A-I	0	Direct
Anaphylotoxins (complement system)	0	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.00002099	Direct
Cytochrome P450	0.00007397	Direct
YWTD domain	0.000757	Direct
EGF-type module	0.0009047	Direct
MMP N-terminal domain	0.001852	Inherited
Kringle modules	0.001861	Inherited
GLA-domain	0.001861	Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain	0.00235	Inherited
Extracellular domain of cell surface receptors	0.00235	Inherited
Blood coagulation inhibitor (disintegrin)	0.004287	Inherited
Leukotriene A4 hydrolase catalytic domain	0.005749	Inherited
Hemopexin-like domain	0.006814	Inherited
Serpins	0.006912	Inherited
Matrix metalloproteases, catalytic domain	0.00726	Inherited
Long-chain cytokines	0.0118	Inherited
Leukotriene A4 hydrolase N-terminal domain	0.01408	Inherited
NADPH-cytochrome p450 reductase-like	0.01408	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.01408	Inherited
Platelet-derived growth factor-like	0.02076	Inherited
TNF receptor-like	0.02093	Inherited
T-box	0.0271	Inherited
Thrombospondin C-terminal domain	0.03378	Inherited
TSP type-3 repeat	0.03378	Inherited
Interleukin 17F, IL-17F	0.03378	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.03378	Inherited
Transforming growth factor (TGF)-beta	0.04367	Inherited
Nuclear receptor ligand-binding domain	0.04573	Inherited
Myosin rod fragments	0.04765	Inherited
Nuclear receptor	0.05159	Inherited
TNF-like	0.05475	Inherited
Fibronectin type II module	0.06438	Inherited
Short-chain cytokines	0.07423	Inherited
Somatomedin B domain	0.09461	Inherited
Pancreatic lipase, N-terminal domain	0.09461	Inherited
Pentraxin (pentaxin)	0.09461	Inherited
Interleukin-1 (IL-1)	0.159	Inherited
Voltage-gated potassium channels	0.1667	Inherited
Forkhead DNA-binding domain	0.2074	Inherited
SPRY domain	0.2673	Inherited
MHC antigen-recognition domain	0.2681	Inherited
C1 set domains (antibody constant domain-like)	0.3181	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.3182	Inherited
C-type lectin domain	0.4771	Inherited
Canonical RBD	1	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Apolipoprotein A-I	0	Direct
Anaphylotoxins (complement system)	0	Direct
Fibrinogen coiled-coil and central regions	0	Direct
Insulin-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.00001296	Direct
Cytochrome P450	0.00001886	Direct
Metalloproteases ("zincins"), catalytic domain	0.0001055	Direct
YWTD domain	0.0005028	Direct
FnI-like domain	0.0005824	Direct
Kringle-like	0.001116	Inherited
PGBD-like	0.001236	Inherited
GLA-domain	0.001464	Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain	0.001916	Inherited
Blood coagulation inhibitor (disintegrin)	0.003484	Inherited
EGF/Laminin	0.004557	Inherited
Leukotriene A4 hydrolase N-terminal domain	0.004921	Inherited
Riboflavin synthase domain-like	0.005066	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.005066	Inherited
Hemopexin-like domain	0.005321	Inherited
Snake toxin-like	0.005357	Inherited
Serpins	0.009306	Inherited
TIMP-like	0.01046	Inherited
Troponin coil-coiled subunits	0.01228	Inherited
Flavoproteins	0.01782	Inherited
Calcium-dependent phosphotriesterase	0.03024	Inherited
Hairpin loop containing domain-like	0.03024	Inherited
Phospholipase A2, PLA2	0.03024	Inherited
TSP type-3 repeat	0.03024	Inherited
MAPEG domain-like	0.03024	Inherited
Nuclear receptor ligand-binding domain	0.03444	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.03923	Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)	0.04051	Inherited
TNF-like	0.04287	Inherited
Myosin rod fragments	0.05426	Inherited
TNF receptor-like	0.05577	Inherited
Somatomedin B domain	0.08505	Inherited
Cytokine	0.1171	Inherited
MHC antigen-recognition domain	0.2279	Inherited
Voltage-gated potassium channels	0.4539	Inherited
RNA-binding domain, RBD	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49410,50242 49410 - Alpha-macroglobulin receptor domain 50242 - TIMP-like	0	Direct
49503,49503 49503 - Cupredoxins 49503 - Cupredoxins	0	Direct
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0.00006122	Direct
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.000269	Direct
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.0007383	Direct
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.001236	Inherited
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.001916	Inherited
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.002026	Inherited
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0.003484	Inherited
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin	0.004921	Inherited
63737,55486 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain	0.004921	Inherited
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.005471	Inherited
53300,69179 53300 - vWA-like 69179 - Integrin domains	0.01228	Inherited
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain	0.01228	Inherited
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.01277	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.0291	Inherited
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat	0.03024	Inherited
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases	0.03024	Inherited
57184,63825 57184 - Growth factor receptor domain 63825 - YWTD domain	0.03024	Inherited
53474,49723 53474 - alpha/beta-Hydrolases 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)	0.03024	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.3079	Inherited
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.4262	Inherited
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.6469	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin	0	Direct
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.001916	Inherited
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.004518	Inherited
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.004921	Inherited
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.004921	Inherited
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.005271	Inherited
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases	0.03024	Inherited
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat	0.03024	Inherited
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.04981	Inherited
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.2101	Inherited
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.2147	Inherited
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0.3349	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Disease Ontology (DO): cardiovascular system disease

Superfamily

Family

Supra-domain (including individual superfamily)